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Drugs for Osteogenesis Imperfecta, Type I (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB): (show all 19)
| id | | Name | Status | Phase | Clinical Trials | Cas Number | PubChem Id |
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| 1 | | Hormone Antagonists | | Phase 3 | 13180 | | | | 2 | | Hormones, Hormone Substitutes, and Hormone Antagonists | | Phase 3 | 13168 | | | | 3 | | Hormones | | Phase 3 | 14415 | | | | 4 | | Cyclosporine | approved, investigational, vet_approved | Phase 1 | 922 | 79217-60-0, 59865-13-3 | 5284373, 6435893 | 1c5f 1cyn 30024_FLUKA 30024_SIGMA 59865-13-3 79217-60-0 AC1L1EQW AC1NQXJE AC1NR4C4 AC1NUQK3 AC1NUZNC AC1O5KOG AC1Q2UDG Ambap59865-13-3 Ambotz59865-13-3 Antibiotic S 7481F1 BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA BPBio1_000496 BRD-A64290322-001-01-6 BRD-A69815203-001-04-3 BRD-K13533483-001-03-0 BSPBio_000450 BSPBio_001596 BSPBio_003186 C 3662 C05086 C1832_SIGMA C3662_SIGMA C62H111N11O12 CB-01-09 MMX CHEBI:106343 CHEBI:328305 CHEBI:4031 CHEMBL160 CHEMBL386389 CHEMBL532318 CID2909 CID5280754 CID5284373 CID5458585 CID5497195 CID6435893 CSA CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)) CYCLOSPORIN A, USP Ciclosporin Ciclosporin (JP15) Ciclosporina Ciclosporine Ciclosporinum Cipol N Cipol-N Consupren Consupren S CsA CsA & IFN.alpha. CyA Cyclokat Cyclosporin Cyclosporin A Cyclosporin A & IFN.alpha. Cyclosporin A Implant Cyclosporin A, Tolypocladium inflatum Cyclosporine (USP) Cyclosporine A Cyclosporine [USAN] D00184 DE-076 DivK1c_000871 EU-0100242 Equoral GNF-Pf-2808 Gengraf Gengraf (TN) HMS1569G12 HMS1791P18 HMS1921L20 HMS1989P18 HMS2089A09 HMS2092F06 HMS502L13 Helv Chim Acta 60: 1568 (1977) | I06-0379 I06-0966 IDI1_000871 KBio1_000871 KBio2_000780 KBio2_003348 KBio2_005916 KBio3_002686 KBioGR_001898 KBioSS_000780 LMPK14000003 LS-257 LS-58836 Lopac0_000242 MLS000028376 MLS001333756 MLS002153454 MLS002207033 Mitogard Modusik-A MolPort-000-760-988 MolPort-005-934-008 MolPort-006-705-994 NCGC00093704-01 NCGC00093704-02 NCGC00093704-03 NCGC00093704-04 NCGC00093704-05 NCGC00093704-06 NCGC00093704-07 NCGC00093704-08 NCGC00164258-01 NCGC00164258-02 NINDS_000871 NSC290193 Neoplanta Neoral Neoral (TN) NeuroSTAT Nova-22007 OL 27-400 OL-27400 OLO-400 Papilock Prestwick2_000435 Prestwick3_000435 Prestwick_731 Pulminiq Ramihyphin A Restasis Restasis (TN) S-Neoral S1514_Selleck SDZ-OXL 400 SMR000058578 SPBio_001467 SPECTRUM1502202 ST-603 Sandimmun Sandimmun Neoral Sandimmune Sandimmune (TN) Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine Sang-2000 Sang-35 SangCyA Sangcya Sigmasporin Sigmasporin Microoral Spectrum2_001484 Spectrum3_001593 Spectrum4_001279 Spectrum5_001628 Spectrum_000300 TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A) Vekacia Zyclorin cyclophorine cyclosporin A cyclosporine from Tolypocladium inflatum (Trichoderma polysporin) nchembio.184-comp6 nchembio.301-comp5 nchembio.342-comp1 | |
| | 5 | | Busulfan | approved, investigational | Phase 1 | 545 | 55-98-1 | 2478 | 1, 4-Dimethanesulfonoxybutane 1, 4-Dimethylsulfonoxybutane 1, {4-Bis[methanesulfonoxy]butane} 1,4-BUTANEDIOL DIMETHANESULFONATE 1,4-Bis(methanesulfonoxy)butane 1,4-Bis(methanesulfonyloxy)butane 1,4-Bis[methanesulfonoxy]butane 1,4-Butanedi yl dimethanesulfonate 1,4-Butanediol dimethanesulfonate 1,4-Butanediol dimethanesulphonate 1,4-Butanediol dimethylsulfonate 1,4-Butanediol, dimethanesulfonate 1,4-Butanediol, dimethanesulphonate 1,4-Butanediyl dimethanesulfonate 1,4-Di(methylsulfonoxy)butane 1,4-Dimesyloxybutane 1,4-Dimethane sulfonyl oxybutane 1,4-Dimethanesulfonoxybutane 1,4-Dimethanesulfonoxylbutane 1,4-Dimethanesulfonyloxybutane 1,4-Dimethanesulphonyloxybutane 1,4-Dimethylsulfonoxybutane 1,4-Dimethylsulfonyloxybutane 2041 C. B 2041 C. B. 2041 C.B 2041 C.B. 4-((Methylsulfonyl)oxy)butyl methanesulfonate 4-methylsulfonyloxybutyl methanesulfonate 55-98-1 AC-198 AC1L1DRQ AC1Q4GRQ AI3-25012 AKOS003614975 AN 33501 Ambap55-98-1 B1022 B2635_FLUKA B2635_SIGMA BRN 1791786 BSPBio_001920 BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE) Bisulfex Busilvex Busulfan Busulfan (JP15/USP/INN) Busulfan GlaxoSmithKline Brand Busulfan Orphan Brand Busulfan Wellcome Busulfan Wellcome Brand Busulfan [INN:JAN] Busulfano Busulfano [INN-Spanish] Busulfanum Busulfanum [INN-Latin] Busulfex Busulphan Busulphane Butanedioldimethanesulfonate Buzulfan C.B. 2041 C6H14O6S2 CB 2041 CCRIS 418 CHEBI:28901 CHEMBL820 CID2478 CPD000058613 Citosulfan D002066 D00248 DB01008 DivK1c_000847 EINECS 200-250-2 FT-0083567 G.T. 41 GT 2041 GT 41 Glaxo Wellcome Brand of Busulfan GlaxoSmithKline Brand of Busulfan Glyzophrol HMS1920I07 HMS2091O09 HMS502K09 | HSDB 7605 I09-1371 IDI1_000847 InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 KBio1_000847 KBio2_000512 KBio2_003080 KBio2_005648 KBio3_001420 KBioGR_000698 KBioSS_000512 LS-1358 Leucosulfan MLS001076666 MYLERAN (TN) Mablin Methanesulfonic Methanesulfonic acid, tetram ethylene ester Methanesulfonic acid, tetramethylene ester Mielevcin Mielosan Mielucin Milecitan Mileran Misulban Mitosan Mitostan MolPort-001-783-406 Myeleukon Myeloleukon Myelosan Myelosanum Mylecytan Myleran Myleran Tablets Myleran tablets Myleran, Busulfex, Busulfan Mylerlan NCGC00090905-01 NCGC00090905-02 NCGC00090905-03 NCGC00090905-04 NCGC00090905-05 NCGC00090905-06 NCGC00090905-07 NCI-C01592 NCI60_041640 NCIMech_000192 NINDS_000847 NSC 750 NSC-750 NSC-750sulphabutin NSC750 Orphan Brand of Busulfan Prestwick_989 S1692_Selleck SAM002554887 SMR000058613 SPBio_000253 SPECTRUM1500152 ST50825921 Spectrum2_000067 Spectrum3_000320 Spectrum4_000259 Spectrum5_000928 Spectrum_000092 Sulfabutin Sulfabutin (VAN) Sulphabutin Tetramethylene Dimethane Sulfonate Tetramethylene bis(methanesulfonate) Tetramethylene bis[methanesulfonate] Tetramethylene dimethane sulfonate Tetramethylene {bis[methanesulfonate]} Tetramethylenester Kyseliny Methansulfonove Tetramethylenester kyseliny methansulfonove Tetramethylenester kyseliny methansulfonove [Czech] UNII-G1LN9045DK WLN: WS1&O4OSW1 Wellcome Brand of Busulfan Wellcome, Busulfan X 149 acid, tetramethylene ester alkylating agent: crosslinks guanine residues busulfan butane-1,4-diyl dimethanesulfonate n-Butane-1,3-di(methylsulfonate) |
| | 6 | | Miconazole | approved, investigational, vet_approved | Phase 1 | 3706 | 22916-47-8 | 4189 | (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole 1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole 1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole 22832-87-7 (NITRATE) 22916-47-8 75319-47-0 AB00053500 AC1L1HM1 AKOS001574474 Aflorix(nitrate) Albistat(nitrate) Andergin(nitrate) BPBio1_000279 BRD-A82396632-001-03-0 BRD-A82396632-008-02-7 BRN 0965511 BSPBio_000253 BSPBio_002033 CCRIS 7924 CHEBI:6923 CHEMBL91 CID4189 CPD-4501 Conofite(nitrate) D00416 DB01110 Dactarin Daktarin IV Daktarin iv DivK1c_000156 EINECS 245-324-5 Epi-Monistat(nitrate) Femizol-M Florid(nitrate) Gyno-Daktar(nitrate) HMS1568M15 HMS2090B21 I14-14342 IDI1_000156 Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI) KBio1_000156 KBio2_001445 KBio2_004013 KBio2_006581 KBio3_001533 KBioGR_000581 KBioSS_001445 LS-78378 Lotrimin AF(nitrate) MCZ MJR 1762 MLS002222203 Micantin (nitrate) Miconasil Nitrate | Miconazol Miconazol [INN-Spanish] Miconazole Miconazole (JP15/USP/INN) Miconazole 3 Miconazole 3 Combination Pack Miconazole 7 Combination Pack Miconazole [USAN:BAN:INN:JAN] Miconazole nitrate salt Miconazole-7 Miconazolo Miconazolo [DCIT] Miconazolum Miconazolum [INN-Latin] Micozole Minostate MolPort-002-557-553 Monazole 7 Monista (nitrate) Monistat Monistat (TN) Monistat 1 Combination Pack Monistat 3 Dual-Pak Monistat 3 Vaginal Ovules Monistat 5 Tampon Monistat 7 Dual-Pak Monistat 7 Vaginal Suppositories Monistat Dual- PAK Monistat IV Monistat iv (TN) Monistat iv (tn) Monistat-Derm NCI60_001353 NCI60_001380 NINDS_000156 NSC 170986 NSC169434 NSC170986 Novo-Miconazole Vaginal Ovules Oprea1_091955 Prestwick0_000067 Prestwick1_000067 Prestwick2_000067 Prestwick3_000067 Prestwick_335 R 18134 R-14,889 SMR001307249 SPBio_000976 SPBio_002174 STK834405 STOCK1S-93556 Spectrum2_001048 Spectrum3_000507 Spectrum4_000061 Spectrum5_001297 Spectrum_000965 UNII-7NNO0D7S5M Vusion Zimycan imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI) miconazole | |
| | 7 | | Cyclophosphamide | approved, investigational | Phase 1 | 2935 | 50-18-0, 6055-19-2 | 2907 | (+-)-Cyclophosphamide (-)-Cyclophosphamide (RS)-Cyclophosphamide 1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine 1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin 2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide 4-Hydroxy-cyclophosphan-mamophosphatide 50-18-0 60007-95-6 6055-19-2 (monohydrate) 75526-90-8 AC1L1EQQ AI3-26198 ASTA ASTA B518 Anhydrous cyclophosphamide Asta B 518 B 518 B-518 BRN 0011744 BSPBio_002099 Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester C 0768 C07888 C7H15Cl2N2O2P CB 4564 CB-4564 CCRIS 188 CHEBI:4027 CHEMBL32520 CHEMBL88 CID2907 CP CPA CTX CY Ciclofosfamida Ciclofosfamida [INN-Spanish] Ciclofosfamide Ciclophosphamide Ciclophosphamide [INN] Clafen Claphene Cycloblastin Cyclophosphamid Cyclophosphamide Cyclophosphamide (INN) Cyclophosphamide (TN) Cyclophosphamide (anhydrous form) Cyclophosphamide (anhydrous) Cyclophosphamide Monohydrate Cyclophosphamide Sterile Cyclophosphamide anhydrous Cyclophosphamide, (+-)-Isomer Cyclophosphamides Cyclophosphamidum Cyclophosphamidum [INN-Latin] Cyclophosphan Cyclophosphane Cyclophosphanum Cyclophosphoramide Cyclostin Cyklofosfamid Cyklofosfamid [Czech] Cytophosphan Cytophosphane Cytoxan Cytoxan (TN) Cytoxan Lyoph D,L-Cyclophosphamide D07760 | DB00531 DivK1c_000246 EINECS 200-015-4 EU-0100238 Endoxan Endoxan R Endoxan-Asta Endoxana Endoxanal Endoxane Enduxan Genoxal HMS2090A12 HSDB 3047 Hexadrin IDI1_000246 KBio1_000246 KBio2_001338 KBio2_003906 KBio2_006474 KBio3_001319 KBioGR_000888 KBioSS_001338 LS-1302 LS-99787 Ledoxina Lopac-C-0768 Lopac0_000238 Lyophilized Cytoxan Mitoxan MolPort-001-783-420 N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide NCGC00015209-01 NCGC00015209-03 NCGC00015209-06 NCGC00091741-02 NCGC00091741-03 NCI-C04900 NCI60_002097 NINDS_000246 NSC 26271 NSC-26271 NSC26271 NSC273033 NSC273034 Neosar Occupation, cyclophosphamide exposure Procytox RCRA waste no. U058 Rcra Waste Number U058 Rcra waste number U058 Revimmune S1217_Selleck SK 20501 SPBio_001071 STK177249 STOCK2S-91217 Semdoxan Sendoxan Senduxan Spectrum2_001146 Spectrum3_000370 Spectrum4_000304 Spectrum5_000795 Spectrum_000858 UNII-6UXW23996M WLN: T6MPOTJ BO BN2G2G Zyklophosphamid Zyklophosphamid [German] bis(2-Chloroethyl)phosphami de cyclic propanolamide bis(2-Chloroethyl)phosphamide cyclic propanolamide ester cyclophosphamide |
| | 8 | | Immunosuppressive Agents | | Phase 1 | 13086 | | | | 9 | | Dermatologic Agents | | Phase 1 | 5806 | | | | 10 | | Calcineurin Inhibitors | | Phase 1 | 1622 | | | | 11 | | Antirheumatic Agents | | Phase 1 | 10956 | | | | 12 | | Antifungal Agents | | Phase 1 | 3696 | | | | 13 | | Alkylating Agents | | Phase 1 | 4827 | | | | 14 | | Anti-Infective Agents | | Phase 1 | 22062 | | | | 15 | | Antineoplastic Agents, Alkylating | | Phase 1 | 4603 | | | | 16 | | Immunoglobulins | | Phase 1 | 6394 | | | | 17 | | Antibodies | | Phase 1 | 6394 | | | | 18 | | Antibodies, Monoclonal | | Phase 1 | 4039 | | | | 19 | | Menthol | approved | | 2606 | 2216-51-5 | 16666 | (− ()-Menthol (+)-Neo-menthol (+)-p-Menthan-3-ol (+-)-(1R*,3R*,4S*)-Menthol (+-)-Menthol (+/-)-Menthol (+/-)-p-Menthan-3-ol (-)-(1R,3R,4S)-Menthol (-)-Menthyl alcohol (-)-menthol (-)-p-Menthan-3-ol (-)-trans-p-Menthan-cis-ol (1R)-(-)-Menthol (1R,2S,5R)-(-)-menthol (1R,2S,5R)-Menthol (1R,3R,4S)-(-)-MENTHOL (1R,3R,4S)-(-)-Menthol (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol (1S, 2S, 5R)-(+)-Neomenthol (1S,2R,5R)-(+)-Isomenthol (1S,2R,5S)-(+)-Menthol (1S,2R,5S)-Menthol (1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol (1r,2s,5r)-(-)-menthol (L)-MENTHOL (R)-(-)-Menthol (r)-(-)-menthol )-Menthol --MENTHOL 1-Menthol 1490-04-6 15356-60-2 15356-70-4 15785_RIEDEL 15785_SIAL 19863P 2-Isopropyl-5-methylcyclohexanol 20747-49-3 2216-51-5 3-p-Menthol 4-Isopropyl-1-methylcyclohexan-3-ol 491-02-1 5-Methyl-2-(1-methylethyl)-cyclohexanol 5-Methyl-2-(1-methylethyl)cyclohexanol 5-methyl-2-(propan-2-yl)cyclohexanol 5-methyl-2-propan-2-ylcyclohexan-1-ol 551376_ALDRICH 551376_FLUKA 588733_ALDRICH 613290_ALDRICH 613290_FLUKA 63660_FLUKA 63670_ALDRICH 63670_FLUKA 63975-60-0 6C6A4A8C-A054-468C-A1F0-F29E39838CF2 89-78-1 98167-53-4 AC1L1B2E AC1L28FR AC1Q1NQ2 AC1Q2QQM AI3-08161 AI3-52408 AKOS000119740 AR-1J3337 BB_NC-0057 BRN 1902288 BRN 3194263 BSPBio_003062 C00400 C10H20O CCRIS 3728 CCRIS 375 CCRIS 4666 CCRIS 9231 CHEBI:15409 CHEBI:545611 CHEMBL256087 CHEMBL470670 CID1254 CID16666 Caswell No. 540 D-(-)-Menthol D-p-Menthan-3-ol D00064 D008610 D04849 D04918 DB00825 DivK1c_000820 EINECS 201-939-0 EINECS 207-724-8 EINECS 216-074-4 EINECS 218-690-9 EINECS 239-387-8 EINECS 239-388-3 EPA Pesticide Chemical Code 051601 FEMA No. 2665 Fisherman's friend lozenges Fisherman's friend lozenges (TN) HMS1922G13 HMS2092L14 HMS502I22 | HSDB 5662 HSDB 593 Headache crystals Hexahydrothymol I06-1216 I14-7371 IDI1_000820 KBio1_000820 KBio2_000785 KBio2_003353 KBio2_005921 KBio3_002562 KBioSS_000785 L-(-)-Menthol L-(-)-menthol L-Menthol L-menthol LMPR0102090001 LS-2353 LS-57201 LS-886 LS-89531 LS-89533 Levomenthol Levomenthol [INN:BAN] Levomentholum Levomentholum [INN-Latin] Levomentol M0321 M0545 M2772_SIAL MENTHOL MLS002207256 Menthacamphor Menthol Menthol (USP) Menthol (VAN) Menthol natural Menthol natural, brazilian Menthol racemic Menthol racemique Menthol racemique [French] Menthol solution Menthol, (1alpha,2beta,5alpha)-Isomer Menthomenthol Menthyl alcohol MolPort-000-849-729 MolPort-001-793-392 NCGC00159382-02 NCGC00159382-03 NCGC00164247-01 NCGC00164247-02 NCI-C50000 NINDS_000820 NOOLISFMXDJSKH-KXUCPTDWBX NSC 2603 NSC 62788 NSC2603 NSC62788 Neoisomenthol Peppermint camphor RACEMIC MENTHOL U.S.P. Racementhol Racementhol [INN:BAN] Racementholum Racementholum [INN-Latin] Racementol Racementol [INN-Spanish] Racemic menthol Robitussin Cough Drops SDCCGMLS-0066659.P001 SMR001306785 SPBio_000869 SPECTRUM1503134 STK802468 Spectrum2_000855 Spectrum3_001561 Spectrum5_001060 Spectrum_000305 Tra-kill tracheal mite killer U.S.P. Menthol U.S.p. Menthol UNII-BZ1R15MTK7 UNII-L7T10EIP3A UNII-YS08XHA860 W266507_ALDRICH W266523_ALDRICH W266590_ALDRICH WLN: L6TJ AY1&1 BQ D1 WLN: L6TJ AY1&1 DQ D1 -L ZINC01482164 cis-1 ,3-trans-1,4-(+-)-menthol cis-1,3-trans-1,4-(+-)-menthol d,l-Menthol d-Menthol d-Neomenthol dl-3-p-Menthanol dl-Menthol dl-Menthol (JP15) l-(-)-Menthol l-Menthol l-Menthol (JP15) l-Menthol (TN) l-Menthol (natural) nchembio862-comp1 p-Menthan-3-ol rac-Menthol |
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Interventional clinical trials:| id | Name | Status | NCT ID | Phase |
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| 1 | Growth Hormone Therapy in Osteogenesis Imperfecta | Completed | NCT00001305 | Phase 3 | | 2 | A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804 | Recruiting | NCT03118570 | Phase 2 | | 3 | Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation | Completed | NCT00705120 | Phase 1 | | 4 | Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta | Not yet recruiting | NCT03064074 | Phase 1 | | 5 | Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility | Completed | NCT03029312 | | | 6 | BBD Longitudinal Study of Osteogenesis Imperfecta | Recruiting | NCT02432625 | | | 7 | Urinary Biomarkers of OI Pathobiology | Recruiting | NCT02531087 | |
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