Osteolysis malady

Wikipedia: Osteolysis refers to an active resorption of bone matrix by osteoclasts as part of an ongoing disease...⁴⁴ more...

MalaCards: Osteolysis is related to polyostotic osteolytic dysplasia, hereditary expansile and breast cancer. An important gene associated with Osteolysis is TNFRSF11A (tumor necrosis factor receptor superfamily, member 11a, NFKB activator), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Development Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs pamidronate disodium and pamidronate and the compounds ivig and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and monocytes, and related mouse phenotypes are respiratory system and craniofacial.

osteolysis 7 32 43

Diseases related to osteolysis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 945)

id	Related Disease	Score	Top Affiliating Genes
1	polyostotic osteolytic dysplasia, hereditary expansile	32.0	TNFRSF11A, TNFRSF11B, TNFSF11, SQSTM1
2	breast cancer	31.5	SERPINB5, BMP6, SRC, CXCL10, CXCL9, CSF1
3	arthritis	30.4	MMP3, IL17A, IL1A, IL1B, IL6, IL8
4	giant cell tumor	27.6	BGLAP, MMP9, CALCA, TNFRSF11A, TNFRSF11B, TNFSF11
5	arterial calcification	27.5	BMP2, BGLAP, CD36, MMP3, IL6, CCL2
6	joint disorders	27.4	MMP3, IL11, IL1R1, IL1RN, IL6, TNF
7	adult t-cell leukemia	26.8	IL2, IL4R, IL7, SRC, CXCL10, CXCL9
8	diabetic neuropathy	26.1	REN, VEGFA, IL1B, IL1RN, CALCA, TNFRSF11B
9	hypercalcemia	25.1	BMP6, BGLAP, CD36, IL1A, IL1B, IL2
10	periodontitis	24.8	CD36, MMP1, MMP13, MMP3, MMP9, IL10
11	leukemia/lymphoma	23.7	VEGFA, BGLAP, MMP9, IL10, IL2, IL6
12	diffuse large b-cell lymphoma	22.6	VEGFA, IL10, IL12B, IL1A, IL1B, IL1RN
13	squamous cell carcinoma	21.4	SERPINB5, VEGFA, VCP, BMP2, BMP6, JUN
14	vasculitis	21.0	REN, VEGFA, BMP6, CD36, MMP1, MMP2
15	b-cell lymphomas	20.2	VEGFA, JUN, IL10, IL12B, IL1A, IL1B
16	neuropathy	19.4	PIK3C2A, REN, VEGFA, VCP, JUN, CD36
17	t-cell leukemia	19.1	VEGFA, VCP, BMP6, JUN, MMP7, MMP9
18	multiple myeloma	19.0	VEGFA, BMP2, BMP6, BGLAP, JUN, CD36
19	myeloma	18.6	VEGFA, VCP, BMP2, BMP6, BGLAP, JUN
20	osteosarcoma	17.9	VEGFA, VCP, BMP2, BMP6, BGLAP, JUN
21	nephropathy	17.7	REN, VEGFA, BMP2, BMP6, JUN, CD36
22	oral squamous cell carcinoma	17.7	PIK3C2A, SERPINB5, VEGFA, BMP2, BMP6, JUN
23	prostatitis	17.1	PIK3C2A, SERPINB5, VEGFA, VCP, BMP2, BMP6
24	paget disease, juvenile	13.9	CALCA, TNFRSF11A, TNFRSF11B, TNFSF11
25	hyperparathyroidism, neonatal severe primary	13.9	NR1I3, PRKAR1A, CXADR
26	multicentric reticulohistiocytosis	13.9	TNF, TNFRSF11B, TNFSF11, CSF1
27	osteopenia/osteoporosis	13.9	BGLAP, CALCA, TNFRSF11B, TNFSF11
28	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.9	BGLAP, TNFRSF11A, TNFRSF1B, TNFSF11, PTH
29	pseudohypoparathyroidism type ib	13.9	BGLAP, PTH, PTHLH
30	idiopathic juvenile osteoporosis	13.9	BGLAP, CD36, CALCA, PTH
31	osteitis fibrosa	13.8	BGLAP, IL11, CALCA, PTH
32	aortic valve stenosis	13.8	BMP2, TNFRSF11B, TNFSF11, SPP1
33	hypocalciuric hypercalcemia	13.8	CALCA, PTH, NR1I3, PRKAR1A, CXADR
34	chst3-related skeletal dysplasia	13.8	MMP13, PTHLH, CTSK, RUNX2
35	tympanosclerosis	13.8	BMP2, CALCA, SPP1
36	cleidocranial dysplasia	13.8	BMP2, BGLAP, MMP13, RUNX2
37	adenoameloblastoma	13.8	MMP2, TNFRSF11B, TNFSF10, TNFSF11
38	humoral hypercalcemia of malignancy	13.8	BGLAP, TNF, TNFRSF11A, TNFSF11, PTHLH, NR1I3
39	transsexualism	13.8	BGLAP, IL6, CALCA, TNFRSF11B, TNFSF11
40	fissured tongue	13.8	IL1B, IL6, TNF
41	stachybotrys chartarum	13.8	IL1A, IL1B, CCL4, CCL3, CSF1
42	monoclonal gammopathy of uncertain significance	13.8	BGLAP, IL6, TNF
43	chronic ulcer of skin	13.8	CD36, MMP1, MMP13
44	monoclonal gammopathy of undetermined significance	13.8	IL1B, IL6, CCL3, TNFRSF11B, TNFSF11
45	spermatocele	13.8	IL6, IL8, TNF
46	osteomalacia	13.8	BGLAP, CD36, CALCA, TNFRSF11B, PTH, PTHLH
47	palindromic rheumatism	13.8	IL1B, TNF, TNFRSF1B
48	hyperphosphatemia	13.8	BMP2, BGLAP, TNFRSF11B, PTH, SPP1, RUNX2
49	rickets	13.8	BGLAP, CD36, CALCA, PTH, NR1I3, ACP5
50	erdheim-chester disease	13.7	IL1B, CCL4, CCL2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pamidronate, pamidronate disodium

MalaCards organs/tissues related to osteolysis:

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MGI Mouse Phenotypes related to osteolysis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	IL12B, MAFB, CALCA, PRKAR1A, RUNX2
2	craniofacial phenotype	MP:0005382	9.5	PRKAR1A, CSF1, RUNX2, NOTCH2, CTSK, PTH
3	hematopoietic system phenotype	MP:0005397	9.4	PTH, PTHLH, CTSK, NOTCH2, PRKAR1A, CXADR
4	embryogenesis phenotype	MP:0005380	8.9	SERPINB5, INHBA, MAFB, SRC, NOTCH2, CXADR
5	endocrine/exocrine gland phenotype	MP:0005379	8.6	GGT1, RUNX2, IL2, MAFB, IFNG, PTH
6	renal/urinary system phenotype	MP:0005367	8.5	MAFB, CXCR4, INHBA, REN, HPX, TNFRSF1B
7	adipose tissue phenotype	MP:0005375	8.2	TLR2, PIK3C2A, CD36, IL1R1, IL6, CCL2
8	liver/biliary system phenotype	MP:0005370	8.1	SQSTM1, VEGFA, CD36, IL1R1, IL2, IL6
9	limbs/digits/tail phenotype	MP:0005371	7.9	ACP5, IL10, CTSK, SRC, PTHLH, PTH
10	integument phenotype	MP:0010771	7.6	CALCA, TNFRSF11A, TNFRSF1B, TNFSF11, PTGS1, PTHLH
11	nervous system phenotype	MP:0003631	7.2	CD36, CXCR4, SQSTM1, CSF1, RUNX2, CXCL12
12	growth/size phenotype	MP:0005378	6.9	CTSK, JUN, BMP6, BMP2, REN, PIK3C2A
13	immune system phenotype	MP:0005387	6.8	HPX, TNF, PTH, PTGS1, PTHLH, SRC
14	tumorigenesis	MP:0002006	6.6	IL1A, TGFB1, TGFBR1, PRKAR1A, TLR2, NOTCH2
15	digestive/alimentary phenotype	MP:0005381	6.5	CXADR, CXCR4, RUNX2, PRKAR1A, INHBA, IL12B
16	reproductive system phenotype	MP:0005389	6.2	SRC, SPP1, NR1I3, TGFB1, PRKAR1A, CSF1
17	behavior/neurological phenotype	MP:0005386	5.6	PTHLH, SRC, SPP1, CTSC, TLR2, CXADR
18	skeleton phenotype	MP:0005390	5.6	MAFB, CALCA, TNFRSF11A, TNFRSF11B, TNFRSF1B, TNFSF10
19	muscle phenotype	MP:0005369	5.3	REN, VEGFA, VCP, CD36, MMP2, MMP9
20	vision/eye phenotype	MP:0005391	5.1	CD36, IL6, IL4, IL1R1, IL10, INHBA
21	mortality/aging	MP:0010768	4.4	IL6, MAPKAP1, MAFB, CCL2, CCL3, IFNG
22	homeostasis/metabolism phenotype	MP:0005376	4.3	PIK3C2A, REN, VEGFA, BMP2, JUN, TNFRSF11A
23	cardiovascular system phenotype	MP:0005385	3.0	TGFBR1, TGFB1, TLR2, NOTCH2, PLAU, PRKAR1A
24	cellular phenotype	MP:0005384	1.9	IL4, PTGS1, PTHLH, SRC, SPP1, CTSC

Articles related to osteolysis:

(show top 50)    (show all 103)

id	Title	Authors	Year	Affiliating Genes
1	Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. (22387013)	Zankl A.... Brown M.A.	2012	MAFB
2	Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice. (19816883)	Pandruvada S.N.... Reddy S.V.	2010	CXCL13
3	Over-expression of receptor activator of nuclear fact or-kappaB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthe tic osteolysis of loosened total hip arthroplasty. (19781765)	Wang C.T.... Hou S.M.	2010	TNFSF11
4	RANKL links arterial calcification with osteolysis. (19423860)	Alexander M.Y.	2009	TNFSF11
5	Breaking down bone: new insight into site-specific me chanisms of breast cancer osteolysis mediated by metalloproteinases. (19759260)	Guise T.A.	2009	TNFSF11
6	Variation in cytokine genes can contribute to severit y of acetabular osteolysis and risk for revision in patients with ABG 1 total h ip arthroplasty: a genetic association study. (19860911)	Gallo J.... Petrek M.	2009	TGFB1, TNF, IL6
7	Enhanced expression and shedding of receptor activato r of NF-kappaB ligand during tumor-bone interaction potentiates mammary tumor-i nduced osteolysis. (19590968)	Nannuru K.C.... Singh R.K.	2009	TNFRSF11B, TNFSF11, TNFRSF11A
8	Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss. (19335218)	Diamond P.... Zannettino A.C.	2009	CXCR4, CD36, CXCL12
9	Endosomal damage and TLR2 mediated inflammasome activ ation by alkane particles in the generation of aseptic osteolysis. (19804908)	Maitra R.... Santambrogio L.	2009	TLR2
10	A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects. (18985071)	Tuysuz B.... Martignetti J.A.	2009	HPX
11	Examination of the mechanisms of osteolysis in patients with metastatic breast cancer. (19360288)	Trinkaus M.... Clemons M.	2009	VEGFA, TNFSF11, TNFRSF11B
12	Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis. (17729302)	Koulouvaris P.... Purdue P.E.	2008	TNF, IL6, CTSK
13	Cytokines as markers of osteolysis in the diagnostics of patients with bone metastases (19188882)	Groblewska M.... Szmitkowski M.	2008	IL7, CSF1
14	Treatment with anti-gamma-glutamyl transpeptidase antibody attenuates osteolysis in collagen-induced arthritis mice. (17680722)	Ishizuka Y.... Niida S.	2007	GGT1
15	Involvement of immunogenetic factors in the development of periprosthetic osteolysis (17877940)	Gallo J.... Petrek M.	2007	IL6, IL8
16	Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases. (17683568)	Morrissey C.... Corey E.	2007	TNFRSF11B, TNFSF11
17	A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. (17942921)	Le Gall C.... Clezardin P.	2007	CTSK
18	Vertebral osteolysis after posterior interbody lumbar fusion with recombinant human bone morphogenetic protein 2: a report of five cases. (17526434)	Lewandrowski K.U.... Calderon R.	2007	BMP2
19	Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. (17427340)	Ulrich-Vinther M.	2007	TNFSF11
20	Osteoclasts; culprits in inflammatory osteolysis. (16356195)	Teitelbaum S.L.	2006	TNF, TNFSF11
21	The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells. (16885353)	Sterling J.A.... Mundy G.R.	2006	PTHLH
22	Erythromycin inhibits wear debris-induced inflammator y osteolysis in a murine model. (16435361)	Ren W.... Wooley P.H.	2006	PIK3C2A
23	Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis. (16595469)	Rakshit D.S.... Purdue P.E.	2006	IL6
24	The role of macrophages in osteolysis of total joint replacement. (15475057)	Ingham E.... Fisher J.	2005	TNF
25	Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. (16322249)	Bendre M.S.... Suva L.J.	2005	IL8, TNFSF11, TNFRSF11A
26	Arthroplasty membrane-derived fibroblasts directly induce osteoclast formation and osteolysis in aseptic loosening. (15885469)	Sabokbar A.... Athanasou N.A.	2005	TNFSF11
27	MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. (15894268)	Lynch C.C.... Futakuchi M.	2005	MMP3, MMP7, TNFSF11
28	RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. (15363860)	Wittrant Y.... RAcdini F.	2004	TNFRSF11B, TNFSF11, TNFRSF11A
29	Familial expansive osteolysis otological and dental manifestations of genetic origin (15711475)	Font N.	2004	CALCA
30	Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo. (14554218)	Schwarz E.M.... Looney R.J.	2003	TNF
31	Periprosthetic osteolysis: induction of vascular endo thelial growth factor from human monocyte/macrophages by orthopaedic biomateria l particles. (12968666)	Miyanishi K.... Smith R.L.	2003	JUN
32	Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. (12649140)	Oyajobi B.O.... Mundy G.R.	2003	CCL3
33	Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. (14578201)	Grimaud E.... Heymann D.	2003	TNFSF11, TNFRSF11B
34	Role of prostaglandin E produced by osteoblasts in osteolysis due to bone metastasis. (12559967)	Ohshiba T.... Ito A.	2003	TNFSF11
35	Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty. (14606512)	Wilkinson J.M.... Eastell R.	2003	TNF
36	Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine model. (12355500)	Yang S.Y.... Wooley P.H.	2002	TNFRSF11B
37	New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C. (12207605)	van Steensel M.A.... Steijlen P.M.	2002	CTSC
38	The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis. (11521937)	Haynes D.R.... Findlay D.M.	2001	TNFRSF11B, TNFSF11, TNFRSF11A
39	Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis. (11741056)	Childs L.M.... Schwarz E.M.	2001	TNF
40	Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. (11389072)	Morony S.... Kostenuik P.J.	2001	TNFRSF11B
41	Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. (10937636)	Schwarz E.M.... O'Keefe R.J.	2000	TNF
42	From metastatic osteolysis a painful message: beginning to understand with osteoprotegerin? (11184451)	BAcnard J.	2000	TNFRSF11B
43	Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis. (11094423)	Schwarz E.M.... O'Keefe R.J.	2000	TNF
44	The Gorham-Stout syndrome (Gorham's massive osteolysis). A report of six cases with histopathological findings. (10872375)	MAPller G.... Delling G.	1999	CALCA
45	Comparative evaluation of markers of bone resorption in patients with breast cancer-induced osteolysis before and after bisphosphonate therapy. (9020487)	Body J.J.... Delmas P.D.	1997	CD36, BGLAP
46	Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. (8833902)	Guise T.A.... Mundy G.R.	1996	PTHLH
47	Clodronate and other bisphosphonates as supportive th erapy in osteolysis due to malignancy. (7546830)	Elomaa I.... Blomqvist C.	1995	CD36
48	Idiopathic carpotarsal osteolysis with Bartter's syndrome. A case report and review of the literature. (7641427)	SzAPke G.... Elek E.	1995	REN
49	Genetic linkage of familial expansile osteolysis to chromosome 18q. (7911698)	Hughes A.E.... Mollan R.A.	1994	TNFRSF11A
50	Plasma monomeric calcitonin as a marker of disease activity in multiple myeloma patients with osteolysis. (1634826)	Monti M.... Cunietti E.	1992	BGLAP

Genes related to osteolysis according to GeneCards:

(show top 50)    (show all 74)

id	Symbol	Description	Score	GeneCards Section Context
1	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.1	Publications, Summaries
2	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.1	Publications, Summaries
3	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
4	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
5	ACP5	acid phosphatase 5, tartrate resistant	11.0	Publications
6	CTSK	cathepsin K	11.0	Publications
7	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
8	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0
9	PTHLH	parathyroid hormone-like hormone	11.0	Publications
10	PTH	parathyroid hormone	11.0
11	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
12	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0
13	IL7	interleukin 7	11.0	Publications
14	IL11	interleukin 11	11.0
15	RUNX2	runt-related transcription factor 2	11.0	Publications
16	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
17	SQSTM1	sequestosome 1	11.0
18	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
19	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
20	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
21	CSF1R	colony stimulating factor 1 receptor	11.0
22	IL17A	interleukin 17A	11.0
23	IL1A	interleukin 1, alpha	11.0	Publications
24	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications
26	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
27	SPP1	secreted phosphoprotein 1	11.0	Publications
28	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
29	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
30	BMP2	bone morphogenetic protein 2	11.0	Publications
31	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
32	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
33	CXADR	coxsackie virus and adenovirus receptor	11.0
34	IL8	interleukin 8	11.0	Publications
35	BMP6	bone morphogenetic protein 6	11.0
36	IL1B	interleukin 1, beta	11.0	Publications
37	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
38	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	11.0	Publications
39	BANF1	barrier to autointegration factor 1	11.0
40	FRZB	frizzled-related protein	11.0	Publications
41	HPX	hemopexin	11.0	Publications
42	CTSC	cathepsin C	11.0	Publications
43	INHBA	inhibin, beta A	11.0	Publications
44	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
45	VCP	valosin containing protein	11.0	Publications
46	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	11.0	Publications
47	CXCL13	chemokine (C-X-C motif) ligand 13	11.0	Publications
48	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
49	NOTCH2	notch 2	11.0
50	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications

Pathways related to osteolysis according to GeneDecks:

(show top 50)    (show all 155)

id	Pathway	Score	Top Affiliating Genes
1	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.2	TNFSF11, PTHLH, SPP1, RUNX2, PRKAR1A, BGLAP
2	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.1	BGLAP, RUNX2, PRKAR1A, SPP1, PTH, TNFSF11
3	RAR-Gamma-RXR-Alpha Degradation36	9.8	CSF1, CXCL9, CXCL13, CXCL12, CCL3, CCL4
4	Hematopoietic cell lineage20	9.4	CD36, IL11, IL1A, IL1B, CSF1R, CSF1
5	Regulation of eIF4 and p70S6K36	9.4	TNFSF10, CCL3, CCL4, IL7, IL4, IL2
6	Amoebiasis20	9.3	TLR2, IL8, IL6, IL1R1, IL1B, IL12B
7	NFAT Signaling and Lymphocyte Interactions36	9.1	TNFSF10, CCL3, CCL2, CCL4, IL7, IL4
8	Toll-like receptor signaling pathway20	9.1	CXCL9, CXCL10, TLR2, CTSK, SPP1, TNF
9	TRAF Pathway36	9.0	TLR2, IL1R1, SRC, IL1B, IL1A, IL12B
10	NF-KappaB (p50-p65) Pathway36	8.9	IL1B, TGFB1, BMP6, CXCL12, IL1R1, IL2
11	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.9	IL1B, IL1A, JUN, BGLAP, TGFBR1, SPP1
12	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.8	RUNX2, TGFBR1, SPP1, PTH, BGLAP, JUN
13	Malaria20	8.8	TGFB1, TLR2, TNF, IL10, IL1B, IFNG
14	Transendothelial Migration of Leukocytes36	8.8	IL8, MMP9, MMP7, MMP3, MMP2, MMP13
15	NF-KappaB Family Pathway36	8.7	IL6, BMP6, IL1A, IL2, IL1B, BMP2
16	PGC1Alpha Pathway36	8.7	TNFSF10, TNFRSF1B, CCL3, CCL4, IL8, BMP2
17	IL-6 Pathway36	8.7	CXCL9, CXCL13, CXCL10, TNFSF11, TNFSF10, CCL3
18	Immune response MIF-mediated glucocorticoid regulation10	8.6	JUN, TNF, IFNG, IL8, IL6, IL2
19	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	IFNG, IL6, IL4R, IL4, IL1B, IL17A
20	Pancreatic Adenocarcinoma36	8.6	IL2, MMP9, MMP7, MMP3, MMP13, BMP2
21	SOCS Pathway36	8.6	IL1A, IL12B, IL11, IL10, BMP6, BMP2
22	Colorectal Cancer Metastasis36	8.5	MMP7, MMP1, MMP2, IFNG, TGFB1, TLR2
23	Cytokine Network36	8.5	TNF, IFNG, IL8, IL6, IL4, IL2
24	Osteoclast differentiation20	8.5	TNFSF11, TNFRSF11B, TNFRSF11A, TNF, IFNG, IL1R1
25	JNK Pathway36	8.5	TNFSF10, BMP6, JUN, IL1R1, IL2, BMP2
26	THC Differentiation Pathway36	8.3	IL10, IL12B, IL2, IL4, IL4R, IFNG
27	Immune response_MIF-mediated glucocorticoid regulation41	8.3	JUN, IL6, IL2, MMP1, IL8, IFNG
28	Chagas disease (American trypanosomiasis)20	8.1	IL6, IL1B, IL12B, IL10, JUN, CCL2
29	MAPK Signaling36	8.1	BMP6, CSF1R, IL1R1, IL1B, IL1A, JUN
30	Akt Signaling36	8.0	IL4, IL2, IL12B, IL11, IL10, BMP2
31	Molecular Mechanisms of Cancer36	7.9	IL2, IL1R1, IL12B, IL11, JUN, BMP6
32	Endothelin-1 Signaling Pathway36	7.9	TNFSF10, CCL3, IL7, IL6, IL4, IL2
33	MIF Mediated Glucocorticoid Regulation36	7.9	CCL2, BMP2, BMP6, IL10, IL11, CCL4
34	Leishmaniasis20	7.9	TGFB1, TLR2, TNF, IL1B, IFNG, IL4
35	all-trans-Retinoic Acid Signaling in Brain36	7.8	CXCL13, CXCL12, CXCL10, TNFSF11, TNFSF10, TNF
36	PEDF Induced Signaling36	7.8	CCL2, CCL4, IL8, IL7, IL6, IL4
37	Tec Kinases Signaling36	7.7	TGFB1, IL2, IL11, IL10, BMP6, BMP2
38	ERK Signaling36	7.6	IL12B, IL11, IL10, BMP6, BMP2, IL1A
39	PAK Pathway36	7.4	IL11, IL7, IL6, IL4, IL2, IL1B
40	MIF Regulation of Innate Immune Cells36	7.3	CSF1, CXCL9, CXCL13, CXCL12, IL1B, IL2
41	Rheumatoid arthritis20	7.2	IFNG, CCL3, CCL2, IL8, IL6, IL1B
42	Glucocorticoid Receptor Signaling36	7.2	BMP6, BMP2, IL4R, IL4, IL2, IL1R1
43	TGF-Beta Pathway36	7.1	CXCL12, TGFBR1, TGFB1, TNFSF10, IL1A, IL12B
44	MAPK Family Pathway36	7.1	CCL4, IL8, IL7, IL6, IL4R, IL4
45	Rho Family GTPases36	7.0	CSF1R, CSF1, CXCL9, CXCL13, CXCL12, CXCL10
46	STAT3 Pathway36	6.8	CCL2, IL10, BMP6, BMP2, IL11, IL12B
47	p38 Signaling36	6.3	CXCL9, CCL4, IL8, IL7, IL6, IL4R
48	JAK-STAT Pathway36	6.3	CCL3, CCL2, CCL4, IL8, IL7, IL6
49	Antioxidant Action of Vitamin-C36	6.1	TNFSF10, TNFRSF1B, TNFRSF11A, TNF, CCL3, CCL2
50	Cytokine-cytokine receptor interaction20	5.1	TNFSF11, IL4R, IL4, IL2, IL1R1, IL1B

Compounds related to osteolysis according to GeneDecks:

(show top 50)    (show all 379)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.6	CSF1, CCL4, PIK3C2A
2	glycosaminoglycan32	10.5	CXCL12, CXCL10, MMP13, CD36, BMP2
3	titanium32	10.4	TNFRSF11B, IL11, CD36, BGLAP, BMP2, TNFSF11
4	cyclophosphamide32 34 9 9	13.4	CXCL9
5	pamidronate32 9 9	11.9	BGLAP, CD36, PTHLH, PTH, TNFSF11, TNFRSF11B
6	h2o232	9.8	CSF1, ACP5, TNFRSF1B, HPX, IL1RN, BGLAP
7	heparan sulfate32 18	10.5	CXCL12, CXCL10, CXADR, TLR2, PLAU, SPP1
8	methylcellulose32	9.5	CSF1, TNFSF10, CCL3, IL7, IL6, IL4
9	progesterone32 42 9 18 9	13.4	SERPINB5, BMP2, MMP7, CSF1, CXCL12, TGFBR1
10	n acetylcysteine32	9.3	CSF1, PLAU, SRC, TNFSF11, TNFSF10, IL1R1
11	12-o-tetradecanoylphorbol 13-acetate32	9.3	MMP13, BMP6, MMP2, MMP3, CSF1R, CSF1
12	zoledronic acid32	9.3	CTSK, SRC, PTHLH, TNFSF11, TNFSF10, TNFRSF11B
13	ccl432	9.2	CXCR4, CXCL9, CXCL12, CXCL10, TLR2, PTHLH
14	peptidoglycan32	9.1	TLR2, TNF, CCL3, CCL4, IL8, IL1RN
15	estrogen32	8.9	PTH, CALCA, IL1RN, IL11, INHBA, MMP3
16	leukotriene b432 42 18	10.8	CSF1, CXCL10, TLR2, ACP5, PTGS1, TNF
17	tgf beta132	8.8	SPP1, BMP6, CD36, MMP1, PTHLH, TNFRSF11B
18	epinephrine32 9 18 9	11.6	BMP6, REN, PIK3C2A, CSF1, CXCR4, CXCL12
19	atorvastatin32 34 9 18 9	12.5	TNF, CCL2, IL1RN, IL10, MMP9, MMP2
20	celecoxib32 42 34 9 18 9	13.3	TNFSF11, TNFSF10, TNFRSF11B, CCL3, IL1B, MMP9
21	pge232	8.3	IL1R1, IL1A, IL17A, MMP3, MMP13, MMP1
22	polyinosinic-polycytidylic acid32	8.2	CXCL10, TLR2, IFNG, CCL3, IL8, IL6
23	cysteine32	8.2	TNFSF11, TNFRSF1B, HPX, IFNG, CCL3, CCL4
24	methotrexate32 34 42 9 9	12.2	GGT1, CXADR, MMP2, MMP1, BMP6, PIK3C2A
25	rapamycin32 42	9.1	BMP2, VEGFA, IL1R1, IL2, CSF1, TGFBR1
26	prednisolone32 9 9	9.9	CCL3, PIK3C2A, CCL4, IL6, IL2, IL1RN
27	neopterin32	7.9	CSF1, CXCL10, TNFRSF1B, TNF, IFNG, CCL3
28	ribonucleic acid32	7.9	CCL3, BMP2, BMP6, CCL2, IL1RN, IL1R1
29	thalidomide32 42 9 9	10.9	VEGFA, CD36, PTGS1, TNFSF10, TNFRSF1B, TNFRSF11B
30	calcium32 9 18 9	10.8	SPP1, PTHLH, PTH, TNFSF11, TNFSF10, TNFRSF1B
31	prostaglandin32	7.8	MMP1, REN, TNF, CCL4, IL6, IL1RN
32	ccl332	7.8	CXCR4, IL11, IL10, MMP9, IL1A, IL1B
33	pdtc32	7.8	MMP9, MMP2, MMP1, JUN, SERPINB5, TGFB1
34	lipid32	7.6	TLR2, ACP5, NR1I3, SPP1, PTHLH, TNFSF11
35	lactate32	7.6	CSF1, MMP3, MMP2, MMP1, BMP6, BMP2
36	rosiglitazone32 9 18 9	10.4	MMP1, CD36, JUN, MMP2, MMP9, CSF1
37	triptolide32	7.2	PTGS1, VEGFA, TNFSF10, TNF, IFNG, CCL3
38	gm-csf32	7.0	CSF1, TGFB1, PTGS1, TNF, IFNG, CCL3
39	sb 20358032 42	7.9	RUNX2, CXCR4, CXCL12, PLAU, SPP1, SRC
40	alanine32	6.7	SRC, PTHLH, PTGS1, CCL3, CCL4, IL7
41	simvastatin32 34 42 9 18 9	11.7	TLR2, PTHLH, TNF, BMP2, VEGFA, PIK3C2A
42	hydrocortisone32 9 9	8.7	CCL3, IL8, IL7, IL6, IL4, IL2
43	pd 98,05932	6.6	RUNX2, CSF1R, CSF1, CXCR4, CXCL12, TGFB1
44	herbimycin a32 42	7.5	IL4, IL2, IL1B, IL1A, IL11, MMP9
45	vegf32	6.4	IL11, MMP9, MMP7, MMP3, MMP13, MMP1
46	ly29400232	6.2	TGFB1, SPP1, SRC, PTGS1, TNFSF11, TNFRSF1B
47	retinoic acid32 42 18	8.2	MMP3, MMP13, MMP1, CD36, JUN, BGLAP
48	thymidine32 18	7.0	CCL3, IL7, IL6, IL4R, IL4, IL2
49	rantes32	5.6	CSF1, CXCR4, CXCL9, CXCL12, CXCL10, TGFB1
50	actinomycin d32	4.7	CSF1, CXCR4, CXCL12, IL4R, IL4, IL2

Cellular components related to osteolysis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	10.2	BMP2, BGLAP, SPP1
2	proteinaceous extracellular matrix	GO:005578	8.4	MMP9, TNFRSF11B, TGFB1, MMP2, MMP13, MMP1
3	external side of plasma membrane	GO:009897	8.3	IL17A, IL4, IFNG, TNF, TNFRSF11A, CXCL10
4	cell surface	GO:009986	7.7	CD36, BMP2, VEGFA, IL1R1, TNF, PLAU
5	extracellular region	GO:005576	4.6	VEGFA, IL1R1, IL2, IL4R, IL6, IL7
6	extracellular space	GO:005615	3.5	CCL3, IL10, IL11, IL12B, IL17A, IL1A

Biological processes related to osteolysis according to GeneDecks:

(show top 50)    (show all 102)

id	Name	GO ID	Score	Top Affiliating Genes
1	osteoblast differentiation	GO:001649	10.6	BGLAP, CCL3, RUNX2
2	osteoclast differentiation	GO:030316	10.6	CSF1, TNFSF11, TNF, TNFRSF11A, CSF1R
3	monocyte chemotaxis	GO:002548	10.5	TNFRSF11A, CALCA, IL6, CCL2, CCL3, TNFSF11
4	bone resorption	GO:045453	10.4	SRC, ACP5, CTSK, IL7, PTH, TNFSF11
5	defense response to Gram-positive bacterium	GO:050830	10.3	MMP7, TNF, IL6, TLR2, ACP5, CD36
6	positive regulation of interleukin-6 production	GO:032755	10.2	CD36, IL1A, IL1B, IL6, TLR2, TNF
7	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1B, IL1RN
8	collagen catabolic process	GO:030574	10.2	MMP1, MMP9, MMP7, MMP3, MMP2, MMP13
9	extracellular matrix disassembly	GO:022617	10.2	MMP9, MMP7, MMP3, MMP2, MMP13, MMP1
10	protein kinase B signaling cascade	GO:043491	10.2	IL1B, CCL2, CCL3, TNF, TGFB1
11	cellular response to organic cyclic compound	GO:071407	10.2	TGFB1, TNF, CCL3, CCL2, IL1B, BMP2
12	response to vitamin D	GO:033280	10.2	CXCL10, TGFB1, SPP1, IL1B, BGLAP
13	cellular response to interleukin-1	GO:071347	10.1	IL8, MMP9, IL17A, CCL2, CCL3
14	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.1	BMP6, INHBA, TGFB1, TGFBR1, BMP2
15	lipopolysaccharide-mediated signaling pathway	GO:031663	10.1	TGFB1, TLR2, TNF, CCL3, CCL2, IL1B
16	germ cell migration	GO:008354	10.0	TGFBR1, TGFB1, CXCR4, CXCL12, CXADR
17	extracellular matrix organization	GO:030198	10.0	TNF, MMP1, SERPINB5, MMP2, MMP3, MMP7
18	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.9	TNFSF11, TNF, IL1B, IL6, TGFB1, TNFRSF11A
19	skeletal system development	GO:001501	9.9	BMP2, PTHLH, PTH, MMP9, FRZB, TGFBR1
20	positive regulation of osteoclast differentiation	GO:045672	9.9	CSF1, TNF, IFNG, TNFSF11, IL12B, IL17A
21	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.8	TNFRSF1B, IFNG, TNF, IL1B
22	response to glucocorticoid stimulus	GO:051384	9.8	IL6, IL1RN, BGLAP, IL10, IL1B, CCL2
23	neutrophil chemotaxis	GO:030593	9.8	IL1B, IL8, CXADR, CCL3, IFNG, SPP1
24	humoral immune response	GO:006959	9.8	NOTCH2, TNF, IL6, CCL2, IFNG, IL7
25	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.7	IL10, IL1B, IL6, TNF, TNFRSF11A, TNFSF11
26	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	IFNG, TNF, IL1B
27	response to mechanical stimulus	GO:009612	9.7	BMP2, MMP9, BGLAP, JUN, CCL2, TNF
28	response to radiation	GO:009314	9.6	CXCL12, TGFB1, TNFSF11, MMP9, JUN
29	positive regulation of tumor necrosis factor production	GO:032760	9.6	TLR2, CD36, IL12B, CCL3, IFNG
30	defense response to virus	GO:051607	9.5	CXCL10, CXADR, IL6, CXCL9, IL12B, IFNG
31	positive regulation of chemokine biosynthetic process	GO:045080	9.5	IL1B, IL4, TNF, IFNG
32	chemotaxis	GO:006935	9.5	IL4, CCL4, CCL2, CXCL9, CXCL12, CCL3
33	macrophage differentiation	GO:030225	9.4	VEGFA, MMP9, CSF1, CSF1R
34	cellular response to lipopolysaccharide	GO:071222	9.4	CCL2, IFNG, TNFRSF1B, IL12B, IL8, IL10
35	negative regulation of growth of symbiont in host	GO:044130	9.4	TLR2, TNF, IFNG, IL12B, IL10, CD36
36	positive regulation of protein complex assembly	GO:031334	9.3	TGFB1, TNF, VCP, VEGFA
37	positive regulation of protein phosphorylation	GO:001934	9.2	BMP2, VEGFA, TNF, TGFB1, CSF1R, IL1B
38	negative regulation of cell proliferation	GO:008285	9.2	IL8, BMP2, JUN, FRZB, INHBA, IL1A
39	anti-apoptosis	GO:006916	9.1	IL10, IL1A, IL1B, IL2, TNF, NOTCH2
40	positive regulation of endothelial cell proliferation	GO:001938	9.1	BMP2, CXCL12, JUN, BMP6, VEGFA, CCL2
41	cell-cell signaling	GO:007267	8.8	IL10, INHBA, BMP2, IL7, PTHLH, CCL3
42	response to hypoxia	GO:001666	8.7	VEGFA, BMP2, MMP9, IL1A, IL1B, CCL2
43	positive regulation of cell proliferation	GO:008284	8.7	IL2, IL7, TNFRSF11A, PTHLH, TGFB1, TGFBR1
44	proteolysis	GO:006508	8.7	MMP3, CTSK, CTSC, MMP2, MMP13, ADAM12
45	cell cycle arrest	GO:007050	8.6	IL8, INHBA, TGFBR1, IFNG, TGFB1, NOTCH2
46	signal transduction	GO:007165	8.6	TNFSF10, CXCL12, CXCL13, CXCL9, CSF1R, TNFRSF11A
47	inflammatory response	GO:006954	8.3	IL1A, IL1B, IL6, IL8, CCL4, CCL2
48	immune response	GO:006955	8.1	CXCL9, CXCL13, CXCL12, IL1RN, TLR2, IL4
49	response to drug	GO:042493	7.5	IFNG, TNF, TNFRSF11B, TGFB1, MMP9, MMP7
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.2	IL11, IL17A, IL1A, INHBA, IFNG, SQSTM1

Molecular functions related to osteolysis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor binding	GO:005149	10.1	IL1A, IL1B, IL1RN
2	chemokine activity	GO:008009	9.8	CCL4, CCL2, IL8, CCL3, CXCL12, CXCL9
3	metalloendopeptidase activity	GO:004222	9.5	MMP13, MMP2, MMP3, MMP7, MMP9, ADAM12
4	receptor binding	GO:005102	9.0	SRC, CALCA, CCL2, BMP2, VCP, REN
5	protein heterodimerization activity	GO:046982	8.3	CXCL13, TGFB1, TLR2, IL12B, INHBA, BMP6
6	growth factor activity	GO:008083	7.5	IL4, IL12B, IL1B, IL2, IL6, IL7
7	cytokine activity	GO:005125	6.5	IL6, IL4, IL2, IL1A, IL17A, IL12B
8	protein binding	GO:005515	3.7	TLR2, NOTCH2, SRC, TNFSF10, TNFRSF1B, TNFRSF11A