Osteomalacia malady

Disease Ontology: A bone remodeling disease that has material basis in a vitamin d deficiency which results in softening located in bone.⁶

MalaCards: Osteomalacia is related to oncogenic osteomalacia and rickets. An important gene associated with Osteomalacia is FGF23 (fibroblast growth factor 23), and among its related pathways are Vitamin D2 (ergocalciferol) metabolism and Vitamin D2 (ergocalciferol) metabolism. The compounds paricalcitol and 24,25-dihydroxyvitamin d3 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Wikipedia: Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to...⁴⁴ more...

Aliases & Descriptions:

osteomalacia 6 7 30 8 32 43

Diseases related to osteomalacia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 337)

id	Related Disease	Score	Top Affiliating Genes
1	oncogenic osteomalacia	33.7	SFRP4, FGF23, FGF7, MEPE, CALCA, PTH
2	rickets	31.6	GC, NBL1, VDR, BGLAP, CD36, FGF23
3	x-linked hypophosphatemia	31.3	BGLAP, FGF23, PHEX
4	hypophosphatasia	30.7	ALPL, ALPP
5	renal tubular acidosis	29.3	CLCN5, ATP6V1B1, HSPG2, PTH
6	paraneoplastic syndromes	28.2	SFRP4, FGF23, FGF7, MEPE, CALCA, PTHLH
7	osteopetrosis	27.5	BGLAP, KHDRBS3, ATP6V1B1, CALCA, TNFRSF11B
8	primary hyperparathyroidism	27.0	VDR, BGLAP, CD36, FGF23, MEN1, ALPP
9	sinusitis	26.7	BGLAP, GSTP1, FGF23, ALPP, CALCA, PTHLH
10	uremia	26.5	VDR, MEN1, ENPP1, ANKRD36C, CASR, CALCA
11	hypophosphatemia	26.3	KL, SFRP4, VDR, CLCN5, BGLAP, FGF23
12	osteoporosis	26.1	KL, GC, NBL1, VDR, BGLAP, KHDRBS3
13	ankylosing spondylitis	25.1	GC, VDR, BGLAP, CD36, GSTP1, ENPP1
14	spondylitis	25.1	GC, VDR, BGLAP, CD36, GSTP1, ENPP1
15	hyperparathyroidism	24.0	KL, GC, NBL1, VDR, BGLAP, S100G
16	rheumatoid arthritis	20.9	KL, GC, VDR, CLU, BGLAP, KHDRBS3
17	hepatitis	20.1	SFRP4, GC, VDR, CLU, BGLAP, S100G
18	arthritis	20.1	KL, GC, VDR, CLU, BGLAP, KHDRBS3
19	hypophosphatemic rickets, autosomal dominant	13.8	SFRP4, FGF23, MEPE, PHEX
20	clear cell adenoma	13.8	ALPP, PTH
21	hypocalciuric hypercalcemia	13.7	CASR, CALCA, PTH
22	vitamin d-dependent rickets type ii	13.7	VDR, CYP27B1
23	ollier disease	13.7	PTH1R, PTHLH
24	jansen's metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTH1R, PTHLH
25	parathyroid disorders	13.7	PTH, PTHLH
26	metaphyseal chondrodysplasia	13.7	FGF23, PTH, PTH1R, PTHLH
27	cerebrotendinous xanthomatosis	13.7	CALCA, CYP3A4, CYP27B1
28	infectious mononucleosis	13.7	BGLAP, FGF7, ALPL
29	pancreatic endocrine carcinoma	13.7	CALCA, PTHLH, SSTR2, SSTR5
30	hereditary hypophosphatemic rickets with hypercalciuria	13.7	FGF23, SLC34A3, SLC34A1
31	hypophosphatemic rickets with hypercalciuria	13.7	FGF23, SLC34A3, SLC34A1
32	auditory system disease	13.7	FGF7, CYP27B1, SLPI
33	xanthomatosis	13.6	CALCA, CYP3A4, CYP27B1, NR1I2
34	clear cell chondrosarcoma	13.6	CD36, ALPP, PTHLH
35	common bile duct disease	13.6	ALPL, ALPP, ALPPL2
36	giant cell tumor	13.6	BGLAP, FGF23, CALCA, TNFRSF11B
37	chronic kidney failure	13.6	VDR, CALCA, CYP27B1
38	osteochondrodysplasia	13.6	BGLAP, ALPL, PTH1R, PTHLH
39	metaphyseal dysplasia	13.6	PTH, PTH1R, PTHLH
40	osteofibrous dysplasia	13.6	BGLAP, CD36, GNAS
41	arterial calcification of infancy	13.6	FGF23, ENPP1, PHEX
42	villonodular synovitis	13.6	BGLAP, TNFRSF11B, PTHLH
43	functioning pituitary adenoma	13.6	GNAS, SSTR1, SSTR2, SSTR3, SSTR5
44	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.6	BGLAP, CASR, PTH
45	osteopenia/osteoporosis	13.6	BGLAP, CD36, CALCA, TNFRSF11B
46	transsexualism	13.6	VDR, BGLAP, CALCA, TNFRSF11B
47	hypoparathyroidism, autosomal dominant	13.6	CASR, PTH
48	mammary paget's disease	13.6	BGLAP, CALCA, TNFRSF11B
49	familial isolated hyperparathyroidism	13.6	MEN1, CASR, PTH
50	parathyroid carcinoma	13.6	MEN1, CASR, PTH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to osteomalacia:

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FMA organs/tissues related to osteomalacia:

¹¹

MGI Mouse Phenotypes related to osteomalacia:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	9.5	PHEX, DMP1, PTH1R, PTH, HSPG2, GNAS
2	hearing/vestibular/ear phenotype	MP:0005377	9.3	TNFRSF11B, CALCA, HSPG2, GNAS, ENPP1, ATP6V1B1
3	other phenotype	MP:0005395	9.2	PHEX, CASR, HSPG2, ALPL, ENPP1, CLU
4	limbs/digits/tail phenotype	MP:0005371	9.2	PTH, PTHLH, DMP1, PHEX, SOST, TNFRSF11B
5	hematopoietic system phenotype	MP:0005397	9.0	LYVE1, ABCC4, SPTA1, PTHLH, PTH, CASR
6	reproductive system phenotype	MP:0005389	8.8	SLC34A1, NR1I2, SPTA1, CYP24A1, ALPP, ALPL
7	digestive/alimentary phenotype	MP:0005381	8.0	PTH1R, PTHLH, SSTR2, SPTA1, PHEX, ABCC4
8	renal/urinary system phenotype	MP:0005367	7.9	CYP27B1, SPTA1, PHEX, ABCC4, SLC34A3, SLC34A1
9	integument phenotype	MP:0010771	7.9	ABCC4, SPTA1, PTHLH, CALCA, CASR, GNAS
10	immune system phenotype	MP:0005387	7.4	HSPG2, PTH, PTHLH, CYP27B1, SPTA1, PHEX
11	skeleton phenotype	MP:0005390	7.4	SLC34A1, ENPP1, MEPE, FGF23, CLCN5, BMP3
12	mortality/aging	MP:0010768	7.3	CASR, TNFRSF11B, PTH, SPTA1, NR1I2, PHEX
13	cardiovascular system phenotype	MP:0005385	7.2	CALCA, TNFRSF11B, PTH, PTHLH, SSTR2, SPTA1
14	cellular phenotype	MP:0005384	7.1	PTHLH, CYP27B1, SSTR1, SPTA1, NR1I2, PHEX
15	behavior/neurological phenotype	MP:0005386	6.9	CALCA, PTHLH, SSTR1, SSTR2, SPTA1, NR1I2
16	nervous system phenotype	MP:0003631	6.6	HSPG2, CALCA, PTHLH, SSTR1, SSTR2, SPTA1
17	growth/size phenotype	MP:0005378	6.5	PTHLH, CYP24A1, CYP27B1, SSTR5, SPTA1, PHEX
18	homeostasis/metabolism phenotype	MP:0005376	4.4	SLC34A1, SLC34A3, SLPI, SOST, ABCC4, PHEX

Articles related to osteomalacia:

(show top 50)    (show all 85)

id	Title	Authors	Year	Affiliating Genes
1	The levels of somatostatin receptors in causative tum ors of oncogenic osteomalacia are insufficient for their agonist to normalize s erum phosphate levels. (20458578)	Ishii A.... Nishizawa Y.	2010	SSTR2, SSTR3, SSTR5
2	Tumor-induced osteomalacia: a case report. (19578602)	Romualdo-Silva D.D.... Purisch S.	2009	FGF23
3	RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor i nduced osteomalacia. (19609206)	Bahrami A.... Folpe A.L.	2009	SFRP4, FGF23
4	Bone turnover and the osteoprotegerin-RANKL pathway i n tumor-induced osteomalacia: a longitudinal study of five cases. (19763378)	Rendina D.... Mossetti G.	2009	TNFRSF11B, FGF23
5	Survey of spine surgeons on attitudes regarding osteo porosis and osteomalacia screening and treatment for fractures, fusion surgery, and pseudoarthrosis. (19328744)	Dipaola C.P.... Rechtine G.R.	2009	PTH
6	Tenofovir-induced osteomalacia. (20149322)	Wanner D.P.... Walker U.A.	2009	ABCC4
7	Predisposition to vitamin D deficiency osteomalacia a nd rickets in females is linked to their 25(OH)D and calcium intake rather than vitamin D receptor gene polymorphism. (19094076)	Ray D.... Sreenivas V.	2009	VDR, PTH
8	Expression analysis of fibroblast growth factor-23, matrix extracellular phosphoglycoprotein, secreted frizzled-related protein-4, and fibroblast growth factor-7: identification of fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein as major factors involved in tumor-induced osteomalacia. (19158050)	Habra M.A.... Hoff A.O.	2008	SFRP4, FGF23, MEPE
9	Clinical impact of somatostatin receptor scintigraphy in the management of tumor-induced osteomalacia. (18936605)	Duet M.... Orcel P.	2008	FGF23
10	Development of tumor-induced osteomalacia in a subcutaneous tumor, defined by venous blood sampling of fibroblast growth factor-23. (18379151)	Ogura E.... Suda T.	2008	FGF23
11	Sporadic adult-onset hypophosphatemic osteomalacia caused by excessive action of fibroblast growth factor 23. (18310982)	Hoshino C.... Ohta M.	2008	FGF23
12	Preoperative tumor localization by means of venous sampling for fibroblast growth factor-23 in a patient with tumor-induced osteomalacia. (18463045)	Westerberg P.A.... Larsson T.E.	2008	FGF23
13	Oncogenic hypophosphataemic osteomalacia: biomarker roles of fibroblast growth factor 23, 1,25-dihydroxyvitamin D3 and lymphatic vessel endothelial hyaluronan receptor 1. (18230836)	Hannan F.M.... Thakker R.V.	2008	FGF23, LYVE1
14	Osteomalacia from Mg-containing antacid: a case repor t of bilateral hip fracture. (17171347)	Sivas F.... AlemdaroA9lu E.	2007	SLPI
15	Tumor-induced osteomalacia: the importance of measuring serum phosphorus levels. (17893691)	Halperin F.... Mulder J.E.	2007	FGF23
16	FGF23-related hypophosphatemic rickets/osteomalacia (17906402)	Ito N.... Fukumoto S.	2007	FGF23
17	A case of phosphaturic mesenchymal tumour (mixed connective tissue variant) that developed in the subcutaneous tissue of a patient with oncogenic osteomalacia and produced fibroblast growth factor 23. (17489977)	Oka M.... Nishigori C.	2007	FGF23
18	Pathophysiology in rickets/osteomalacia (17906401)	Takeuchi Y.	2007	VDR, FGF23
19	Osteomalacia associated with a fibroblast growth factor-23 secreting chest wall tumor. (17723842)	Paul S.... Mentzer S.J.	2007	FGF23
20	Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. (16207822)	Xu Y.... Thummel K.E.	2006	CYP3A4, NR1I2, CYP24A1
21	Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia. (16551733)	Imel E.A.... Econs M.J.	2006	FGF23
22	Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. (17033621)	Feng J.Q.... White K.E.	2006	DMP1
23	Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. (16691293)	Zhou C.... Thummel K.E.	2006	VDR, CYP3A4, NR1I2
24	Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. (16969146)	Koriyama N.... Tei C.	2006	FGF23
25	Persistent tumor-induced osteomalacia confirmed by elevated postoperative levels of serum fibroblast growth factor-23 and 5-year follow-up of bone density changes. (15901526)	Zimering M.B.... Econs M.J.	2005	FGF23
26	Foot tumor and diffuse pain: a case of oncogenic osteomalacia (16142164)	Poizat F.... Baldet P.	2005	FGF23
27	Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification (15985196)	Pascussi J.M.... Vilarem M.J.	2005	NR1I2
28	Fibroblast growth factor 23, a new phosphaturic factor in hypophosphatemic rickets/osteomalacia (16279684)	Nishizawa Y.... Imanishi Y.	2005	FGF23
29	Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. (14707860)	Folpe A.L.... Weiss S.W.	2004	FGF23
30	Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia. (15292336)	Takeuchi Y.... Fujita T.	2004	FGF23
31	Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. (15001995)	Toyosawa S.... Komori T.	2004	DMP1
32	Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia. (12970268)	Nelson A.E.... Bligh P.C.	2003	FGF23
33	Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12711740)	Jonsson K.B.... Juppner H.	2003	FGF23, PHEX
34	Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. (12890852)	Kida Y.	2003	FGF23
35	Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. (12414858)	Yamazaki Y.... Fukumoto S.	2002	FGF23
36	New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia. (12187320)	Kumar R.	2002	SFRP4, FGF23
37	Somatic mutations of the MEN1 gene and microsatellite instability in a case of tertiary hyperparathyroidism occurring during high phosphate therapy for acquired, hypophosphatemic osteomalacia. (11701736)	Sato K.... Takano K.	2001	MEN1
38	Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. (11414762)	Argiro L.... Ecarot B.	2001	PHEX, MEPE
39	Cloning and characterization of FGF23 as a causative factor of tumor- induced osteomalacia. (11344269)	Shimada T.... Yamashita T.	2001	FGF23
40	Fibroblast growth factor (FGF)-23 and hypophosphatemic rickets/osteomalacia. (11873859)	Fukumoto S.... Yamashita T.	2001	FGF23
41	A case of neuroendocrine oncogenic osteomalacia associated with a PHEX and fibroblast growth factor-23 expressing sinusidal malignant schwannoma. (11595624)	John M.R.... Blind E.	2001	FGF23, PHEX
42	Tumor-induced osteomalacia and the regulation of phosphate homeostasis. (10962341)	Kumar R.	2000	PHEX
43	A PHEX gene mutation is responsible for adult-onset vitamin D- resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. (9768646)	Econs M.J.... Bergen H.	1998	PHEX
44	Oncogenic osteomalacia: is there a new phosphate regulating hormone? (9497867)	Nelson A.E.... Mason R.S.	1997	PHEX
45	Osteomalacia and osteoporosis in a woman with ankylosing spondylitis. (9157786)	Kohlmeier L.A.... Leboff M.S.	1996	CALCA
46	Hypophosphatemic osteomalacia acquired after renal transplantation: a a cause of severe osteoporosis (7569451)	GonzA!lez F.... Roessler E.	1995	BGLAP
47	Carboxyterminal propeptide of type I procollagen in osteomalacia. (7953986)	Li F.... Moniz C.	1994	ALPP
48	Serum osteocalcin is increased in patients with osteomalacia: correlations with biochemical and histomorphometric findings. (1569162)	Demiaux B.... Delmas P.D.	1992	BGLAP
49	A case of primary SjAPgren's syndrome presenting as osteomalacia secondary to renal tubular acidosis (1857996)	Okazaki H.... Kano S.	1991	HSPG2
50	Osteomalacia and osteoporosis in femoral neck fracture. (2268750)	Hordon L.D.... Peacock M.	1990	GC

Genes related to osteomalacia according to GeneCards:

(show top 50)    (show all 54)

id	Symbol	Description	Score	GeneCards Section Context
1	FGF23	fibroblast growth factor 23	11.1	Summaries, Publications
2	DMP1	dentin matrix acidic phosphoprotein 1	11.1	Publications, Summaries
3	SFRP4	secreted frizzled-related protein 4	11.0	Publications
4	MEPE	matrix extracellular phosphoglycoprotein	11.0	Publications
5	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0	Publications
6	PTH1R	parathyroid hormone 1 receptor	11.0	Publications
7	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
8	SSTR1	somatostatin receptor 1	11.0	Publications
9	SSTR3	somatostatin receptor 3	11.0	Publications
10	PTH	parathyroid hormone	11.0	Publications
11	SSTR5	somatostatin receptor 5	11.0	Publications
12	FGF7	fibroblast growth factor 7	11.0	Publications
13	CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	11.0	Publications
14	SSTR2	somatostatin receptor 2	11.0	Publications
15	NR1I2	nuclear receptor subfamily 1, group I, member 2	11.0	Publications
16	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
17	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0
18	ALPL	alkaline phosphatase, liver/bone/kidney	11.0
19	ALPP	alkaline phosphatase, placental	11.0	Publications
20	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
21	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
22	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
23	CASR	calcium-sensing receptor	11.0	Publications
24	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
25	PTHLH	parathyroid hormone-like hormone	11.0
26	GNAS	GNAS complex locus	11.0
27	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
28	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
29	NBL1	neuroblastoma, suppression of tumorigenicity 1	11.0
30	SLC34A3	solute carrier family 34 (sodium phosphate), member 3	11.0	Publications
31	S100G	S100 calcium binding protein G	11.0	Publications
32	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
33	SOST	sclerostin	11.0	Publications
34	LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	11.0	Publications
35	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.0
36	EMP1	epithelial membrane protein 1	11.0
37	BMP3	bone morphogenetic protein 3	11.0	Publications
38	ALPPL2	alkaline phosphatase, placental-like 2	11.0
39	SLC17A1	solute carrier family 17 (sodium phosphate), member 1	11.0	Publications
40	CLCN5	chloride channel, voltage-sensitive 5	11.0
41	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	11.0
42	MEN1	multiple endocrine neoplasia I	11.0	Publications
43	CLU	clusterin	11.0	Publications
44	ANKRD36C	ankyrin repeat domain 36C	11.0	Publications
45	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	11.0
46	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0
47	GC	group-specific component (vitamin D binding protein)	11.0	Publications
48	KNTC1	kinetochore associated 1	11.0	Disorders
49	KL	klotho	11.0
50	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	11.0

Pathways related to osteomalacia according to GeneDecks:

(show all 18)

id	Pathway	Score	Top Affiliating Genes
1	Vitamin D2 (ergocalciferol) metabolism10	10.5	CYP3A4, CYP24A1
2	Vitamin D2 (ergocalciferol) metabolism41	10.4	CYP27B1, CYP3A4, CYP24A1
3	Class B/2 (Secretin family receptors)38	10.2	PTHLH, PTH1R, PTH, CALCA, GNAS
4	Folate biosynthesis20	10.2	ALPPL2, ALPP, ALPL
5	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.1	PTHLH, PTH1R, PTH, GNAS, BGLAP, VDR
6	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.1	PTHLH, PTH1R, PTH, GNAS, BGLAP, VDR
7	Class A/1 (Rhodopsin-like receptors)38	9.9	SSTR5, SSTR3, SSTR2, SSTR1, CCL27
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.9	VDR, CYP27B1, CYP3A4, CYP24A1, PTH1R, PTH
9	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.9	CYP27B1, CYP3A4, CYP24A1, PTH1R, PTH, TNFRSF11B
10	Endocrine and other factor-regulated calcium reabsorption20	9.9	PTH1R, GNAS, VDR, KL
11	NAD metabolism10	9.8	ALPPL2, ALPL, ENPP1
12	NAD metabolism41	9.8	ALPPL2, ALPP, ALPL, ENPP1
13	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.0	NR1I2, CYP3A4, GSTT1, GSTP1, VDR
14	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	8.7	GSTT1, GSTP1, GSTM1
15	Naphthalene metabolism41	8.6	CYP3A4, GSTT1, GSTP1, GSTM1
16	Naphthalene metabolism10	8.6	CYP3A4, GSTT1, GSTP1, GSTM1
17	Drug metabolism - cytochrome P45020	8.4	GSTM1, GSTP1, GSTT1, CYP3A4
18	Metabolism of xenobiotics by cytochrome P45020	8.1	CYP3A4, GSTT1, GSTP1, GSTM1

Compounds related to osteomalacia according to GeneDecks:

(show top 50)    (show all 166)

id	Compound	Score	Top Affiliating Genes
1	paricalcitol32 9 9	12.3	PTH, CYP24A1, CYP3A4, CYP27B1, VDR
2	24,25-dihydroxyvitamin d332	10.2	CYP27B1, CYP24A1, CALCA, ALPP, BGLAP, VDR
3	teriparatide32 9 9	12.2	CD36, BGLAP, CALCA, TNFRSF11B, PTH1R
4	etidronate32	10.2	SLPI, CD36, TNFRSF11B, CALCA, ALPP, BGLAP
5	calcium carbonate32	10.2	ALPP, PTHLH, BGLAP, PTH, CD36, CALCA
6	tartrate32	10.1	CALCA, CD36, ALPP, SLPI, PTHLH, BGLAP
7	risedronate32 42 9 9	13.1	TNFRSF11B, CALCA, ALPP, SLPI, BGLAP, CD36
8	alizarin32	10.1	SLPI, ALPP, ALPL, CD36, BGLAP
9	vitamin k232	10.1	NR1I2, TNFRSF11B, CALCA, ALPP, CD36, BGLAP
10	clodronate32 9 9	12.1	PTHLH, BGLAP, TNFRSF11B, CALCA, SLPI, CD36
11	octreotide32 42 9 9	13.1	FGF23, GNAS, SSTR5, SSTR3, CALCA, PTHLH
12	pyridinoline32	10.0	SLPI, PTHLH, CALCA, TNFRSF11B, CD36, ALPP
13	ipriflavone32	10.0	SLPI, ALPP, BGLAP
14	zoledronic acid32	10.0	SLPI, PTHLH, BGLAP, TNFRSF11B, CD36, ALPP
15	pamidronate32 9 9	12.0	PTH, BGLAP, CD36, ALPP, CASR, CALCA
16	alfacalcidol32 9 9	11.9	GC, VDR, BGLAP, CALCA, CYP24A1, CYP27B1
17	phosphorus32	9.9	VDR, FGF23, ALPP, CASR, CALCA, PTH
18	raloxifene32 9 9	11.9	VDR, SLPI, BGLAP, CD36, CALCA, CYP3A4
19	alendronate32 9 9	11.9	ALPP, CALCA, TNFRSF11B, PTH, PTHLH, SLPI
20	pge232	9.9	CASR, TNFRSF11B, CYP24A1, CYP27B1, SLPI, HSPG2
21	22-oxacalcitriol32	9.8	PTHLH, VDR, GC, BGLAP, CD36, ALPP
22	hydrocortisone32 9 9	11.7	CD36, FGF7, ALPP, CALCA, TNFRSF11B, PTHLH
23	estradiol32 9 18 9	12.7	CYP3A4, NR1I2, TNFRSF11B, GC, SLPI, LYVE1
24	eb 108932	9.7	CYP27B1, CYP24A1, PTHLH, BGLAP, CLU, VDR
25	hydroxyproline32 18	10.5	BGLAP, TNFRSF11B, CD36, ALPP, CALCA, PTH
26	forskolin32 42 9 9	12.5	FGF7, GNAS, HSPG2, CASR, CALCA, TNFRSF11B
27	thyroxine32 18	10.5	TNFRSF11B, NR1I2, PTHLH, ALPP, BGLAP, PTH
28	deoxypyridinoline32	9.4	BGLAP, KHDRBS3, PTH, SLPI, TNFRSF11B, CALCA
29	tamoxifen32 34 9 9	12.4	NR1I2, SSTR2, CYP3A4, PTHLH, PTH, TNFRSF11B
30	ribonucleic acid32	9.3	CASR, CLU, FGF7, GNAS, PTH, SSTR2
31	25-hydroxyvitamin d32	9.1	VDR, BGLAP, CD36, FGF23, ALPP, CASR
32	hydroxyapatite32	9.1	CASR, TNFRSF11B, PTHLH, DMP1, SLPI, ALPP
33	cyclic amp32 18	10.1	ALPPL2, HSPG2, PTH, CASR, GNAS, ENPP1
34	thymidine32 18	10.0	VDR, FGF7, PTH1R, CLU, GNAS, LYVE1
35	cycloheximide32	9.0	HSPG2, PTHLH, PTH, TNFRSF11B, ALPP, FGF7
36	steroid32	8.5	CLU, GC, NR1I2, GSTT1, SLPI, LYVE1
37	1,25 dihydroxy vitamin d332	8.5	CLU, BGLAP, S100G, FGF23, FGF7, ALPP
38	dexamethasone32 42 34 9 9	12.4	PTHLH, CCL27, ALPP, HSPG2, TNFRSF11B, PTH
39	adenylate32	8.4	GSTP1, SSTR2, CALCA, SSTR1, CASR, HSPG2
40	paraffin32	8.2	CLU, BGLAP, CYP27B1, CD36, SSTR2, GSTP1
41	calcitriol32 42 9 18 9	11.9	CLU, BMP3, VDR, GC, SFRP4, BGLAP
42	retinoic acid32 42 18	9.7	SLPI, VDR, GC, CLU, CYP24A1, CYP3A4
43	vegf32	7.7	MEN1, FGF7, SLPI, SSTR2, KL, PTHLH
44	testosterone32 9 18 9	10.5	GC, PTHLH, PTH, TNFRSF11B, CALCA, FGF7
45	creatinine32	7.4	CASR, TNFRSF11B, CCL27, FGF23, GSTT1, GSTP1
46	ascorbic acid32 18	8.4	GSTP1, GSTM1, GSTT1, CD36, ALPP, HSPG2
47	vitamin d32	7.1	SLC34A1, PTHLH, DMP1, CYP24A1, CYP27B1, NR1I2
48	serine32	7.0	GSTP1, PTHLH, PTH1R, TNFRSF11B, CASR, CLU
49	estrogen32	5.9	SSTR2, CYP27B1, CYP24A1, PTHLH, PTH1R, PTH
50	calcium32 9 18 9	7.6	SLC34A1, SLC34A3, SOST, PHEX, NR1I2, SPTA1

Cellular components related to osteomalacia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	9.5	S100G, ATP6V1B1, ENPP1, PTH1R, SLC34A1
2	integral to plasma membrane	GO:005887	8.5	LYVE1, SLC17A1, SLC34A1, PHEX, SSTR5, SSTR3
3	extracellular region	GO:005576	8.0	HSPG2, CALCA, TNFRSF11B, PTH, PTHLH, SLPI
4	extracellular space	GO:005615	7.7	KL, SOST, PTHLH, PTH, TNFRSF11B, CALCA
5	plasma membrane	GO:005886	6.6	SSTR3, SSTR5, PHEX, ABCC4, SLC34A3, SLC34A1

Biological processes related to osteomalacia according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	vitamin D catabolic process	GO:042369	10.6	CYP27B1, CYP24A1, FGF23
2	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	10.5	CYP27B1, FGF23, VDR
3	somatostatin signaling pathway	GO:038170	10.5	SSTR5, SSTR3, SSTR2, SSTR1
4	phosphate ion homeostasis	GO:055062	10.4	SLC34A1, FGF23, SFRP4
5	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	10.4	SSTR5, SSTR3, SSTR2, SSTR1, PTH1R
6	response to vitamin D	GO:033280	10.3	CYP27B1, CYP24A1, ALPL, BGLAP
7	cellular response to glucocorticoid stimulus	GO:071385	10.3	SSTR5, SSTR3, SSTR2
8	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	10.3	PTHLH, PTH1R, PTH, CALCA
9	biomineral tissue development	GO:031214	10.2	MEPE, ENPP1, DMP1, PHEX
10	cellular phosphate ion homeostasis	GO:030643	10.2	SLC34A3, ENPP1, FGF23
11	osteoblast development	GO:002076	10.2	BGLAP, MEN1, PTH1R, PTHLH
12	response to magnesium ion	GO:032026	10.2	TNFRSF11B, SLC34A3, SLC34A1
13	vitamin D receptor signaling pathway	GO:070561	10.2	CYP24A1, VDR
14	vitamin D metabolic process	GO:042359	10.2	CYP27B1, CYP3A4, CYP24A1, GC
15	bone mineralization	GO:030282	10.2	BGLAP, PTH1R, CYP27B1
16	phosphate ion transport	GO:006817	10.2	SLC17A1, SLC34A1, SLC34A3
17	steroid metabolic process	GO:008202	10.0	GC, CYP24A1, CYP3A4, CYP27B1, NR1I2
18	regulation of bone mineralization	GO:030500	10.0	CYP27B1, ENPP1, BGLAP
19	cAMP metabolic process	GO:046058	10.0	PTH, PTHLH
20	negative regulation of ossification	GO:030279	9.9	ENPP1, CALCA, SOST
21	ossification	GO:001503	9.9	SOST, DMP1, CASR, ATP6V1B1, BMP3
22	cell-cell signaling	GO:007267	9.9	PHEX, SSTR3, SSTR2, SSTR1, PTHLH, PTH
23	negative regulation of cell proliferation	GO:008285	9.7	SSTR5, SSTR3, SSTR2, SSTR1, CYP27B1, PTHLH
24	skeletal system development	GO:001501	9.7	VDR, PHEX, PTHLH, PTH1R, PTH, TNFRSF11B
25	xenobiotic metabolic process	GO:006805	8.9	NR1I2, CYP27B1, CYP3A4, CYP24A1, GSTP1, GSTM1

Molecular functions related to osteomalacia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	somatostatin receptor activity	GO:004994	10.2	SSTR1, SSTR2, SSTR3, SSTR5
2	sodium-dependent phosphate transmembrane transporter activity	GO:015321	9.8	SLC17A1, SLC34A1, SLC34A3
3	alkaline phosphatase activity	GO:004035	9.8	ALPL, ALPP, ALPPL2
4	vitamin D binding	GO:005499	9.4	KL, GC, VDR, S100G
5	glutathione transferase activity	GO:004364	8.5	GSTM1, GSTP1, GSTT1