MCID: OST011
MIFTS: 52

Osteomalacia

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteomalacia

MalaCards integrated aliases for Osteomalacia:

Name: Osteomalacia 12 72 49 51 14 69
Adult Rickets 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10573
ICD9CM 34 268.2
NCIt 46 C26838

Summaries for Osteomalacia

NIH Rare Diseases : 49 Osteomalacia is a disease that is characterized by a weakening of the bone, often due to a deficiency of vitamin D. This vitamin supports the development of the bones of the body, so when there are low levels of vitamin D, the bones are not strong enough. Symptoms of osteomalacia can include muscle weakness, bone pain, and walking with a waddling gait. Pain is especially likely to occur in the lower back, hips, and legs. The weakening of the bones may also cause them to easily fracture.  Osetomalacia can be caused by having a low level of vitamin D in the diet or lack of sun exposure. The condition may also be the result of an underlying disease such as celiac disease, or kidney or liver disorders.  Diagnosis of osteomalacia is possible through blood or urine tests to check for vitamin D levels or a bone biopsy. Treatment options include supplementing the diet with more vitamin D or calcium. Any underlying condition will also need to be treated.   Last updated: 9/23/2016

MalaCards based summary : Osteomalacia, also known as adult rickets, is related to oncogenic osteomalacia and hypophosphatasia. An important gene associated with Osteomalacia is DMP1 (Dentin Matrix Acidic Phosphoprotein 1), and among its related pathways/superpathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Nuclear Receptors in Lipid Metabolism and Toxicity. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A bone remodeling disease that has material basis in a vitamin D deficiency which results_in softening located in bone.

Wikipedia : 72 Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to... more...

Related Diseases for Osteomalacia

Diseases related to Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 oncogenic osteomalacia 33.4 DMP1 FGF23 PHEX PTHLH SFRP4
2 hypophosphatasia 32.3 ALPL PHEX
3 autosomal recessive hypophosphatemic rickets 31.6 DMP1 FGF23 PHEX
4 hypophosphatemic rickets, x-linked dominant 31.3 DMP1 FGF23 PHEX SFRP4 VDR
5 rickets 31.1 ALPL BGLAP DMP1 FGF23 PHEX VDR
6 hypophosphatemic rickets, x-linked recessive 31.1 CYP24A1 DMP1 FGF23 PHEX SFRP4 VDR
7 hypophosphatasia, adult 30.9 ALPL BGLAP CALCA
8 paraneoplastic syndromes 30.2 FGF23 PTHLH
9 raine syndrome 30.2 DMP1 FGF23
10 renal osteodystrophy 30.2 BGLAP CALCA CASR FGF23 VDR
11 cohen-gibson syndrome 29.9 BGLAP FGF23
12 primary biliary cirrhosis 29.6 BGLAP NR1I2 VDR
13 hypophosphatemic rickets, autosomal dominant 29.6 FGF23 PHEX SFRP4
14 hypercalciuria, absorptive, 2 29.6 CASR VDR
15 hypophosphatemia 29.6 BGLAP DMP1 FGF23 PHEX SFRP4
16 hypophosphatemic rickets with hypercalciuria, hereditary 29.3 DMP1 FGF23 PHEX SFRP4
17 fibrous dysplasia 29.3 BGLAP CALCA FGF23
18 osteitis fibrosa 29.1 BGLAP CALCA CASR
19 pseudohypoparathyroidism 28.9 BGLAP PTHLH
20 hypoparathyroidism 28.5 BGLAP CASR FGF23 PTHLH
21 secondary hyperparathyroidism of renal origin 28.3 BGLAP CALCA CASR FGF23 VDR
22 hyperparathyroidism 28.0 BGLAP CALCA CASR FGF23 PHEX PTHLH
23 primary hyperparathyroidism 27.9 BGLAP CALCA CASR FGF23 PTHLH VDR
24 parathyroid adenoma 27.9 BGLAP CALCA CASR PTHLH
25 hypercalcemia, infantile, 1 27.6 CALCA CASR CYP24A1 PTHLH VDR
26 osteoporosis 27.3 ALPL BGLAP CALCA CASR CYP24A1 FGF23
27 axial osteomalacia 12.5
28 osteomalacia, sclerosing, with cerebral calcification 11.9
29 fanconi renotubular syndrome 1 11.1
30 renal tubular acidosis, distal 11.1
31 renal tubular acidosis, distal, autosomal dominant 10.8
32 hypophosphatemic rickets, autosomal recessive, 1 10.8
33 vitamin d hydroxylation-deficient rickets, type 1a 10.8
34 dent disease 1 10.8
35 nephrolithiasis, x-linked recessive, with renal failure 10.8
36 hypophosphatemic rickets, autosomal recessive, 2 10.8
37 fanconi renotubular syndrome 2 10.8
38 fanconi renotubular syndrome 3 10.8
39 osteopetrosis 10.8
40 slc4a1-associated distal renal tubular acidosis 10.8
41 opsismodysplasia 10.4 FGF23 PHEX
42 familial tumoral calcinosis 10.4 FGF23 PHEX
43 arterial calcification of infancy 10.4 FGF23 PHEX
44 enthesopathy 10.3 DMP1 FGF23 PHEX
45 fanconi syndrome 10.3
46 impaired renal function disease 10.2 BGLAP FGF23
47 bone mineral density quantitative trait locus 15 10.2
48 bone mineral density quantitative trait locus 8 10.2
49 pyle disease 10.1 PTHLH SFRP4
50 adult syndrome 10.1

Comorbidity relations with Osteomalacia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Osteoporosis

Graphical network of the top 20 diseases related to Osteomalacia:



Diseases related to Osteomalacia

Symptoms & Phenotypes for Osteomalacia

MGI Mouse Phenotypes related to Osteomalacia:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 ALPL CASR CYP24A1 DMP1 FGF23 PHEX
2 homeostasis/metabolism MP:0005376 10.1 ALPL CASR CYP24A1 DMP1 FGF23 NR1I2
3 hematopoietic system MP:0005397 10.03 ALPL CASR DMP1 FGF23 PHEX PTHLH
4 digestive/alimentary MP:0005381 10.02 CASR FGF23 PHEX PTHLH SFRP4 VDR
5 immune system MP:0005387 9.97 ALPL CASR DMP1 FGF23 PHEX PTHLH
6 mortality/aging MP:0010768 9.91 VDR ALPL CASR CYP24A1 FGF23 NR1I2
7 craniofacial MP:0005382 9.89 ALPL DMP1 PHEX PTHLH VDR
8 limbs/digits/tail MP:0005371 9.87 ALPL DMP1 FGF23 PHEX PTHLH SFRP4
9 renal/urinary system MP:0005367 9.76 CASR CYP24A1 DMP1 FGF23 PHEX PTHLH
10 reproductive system MP:0005389 9.5 NR1I2 PTHLH SFRP4 ALPL CYP24A1 FGF23
11 skeleton MP:0005390 9.28 ALPL CASR CYP24A1 DMP1 FGF23 PHEX

Drugs & Therapeutics for Osteomalacia

Drugs for Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 1406-16-2
3
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 10883523 5280795 6221
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
5 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2
6 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
7 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1
8 Ergocalciferols Phase 4,Phase 1,Phase 2
9 Hormones Phase 4,Phase 1
10 Micronutrients Phase 4,Phase 1,Phase 2
11 Trace Elements Phase 4,Phase 1,Phase 2
12 Vitamins Phase 4,Phase 1,Phase 2
13 Retinol palmitate Phase 4
14 Calciferol Nutraceutical Phase 4,Phase 1,Phase 2
15 Vitamin D2 Nutraceutical Phase 4,Phase 1,Phase 2
16 retinol Nutraceutical Phase 4
17
Teriparatide Approved, Investigational Phase 3 52232-67-4 16133850
18 Mitogens Phase 3,Phase 2,Phase 1
19 Antibodies, Monoclonal Phase 3,Phase 2
20
Somatostatin Approved, Investigational Phase 2,Early Phase 1 38916-34-6, 51110-01-1 53481605
21 Cariostatic Agents Phase 2
22 Fluorides Phase 2
23 Protective Agents Phase 2
24 Calcifediol Phase 1, Phase 2 19356-17-3
25 Calcium, Dietary Phase 1, Phase 2
26 Calcimimetic Agents Phase 1
27 Cinacalcet Hydrochloride Phase 1
28 Hormone Antagonists Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
30
Menthol Approved Early Phase 1 2216-51-5 16666
31
Acetylcholine Approved 51-84-3 187
32
Nitroprusside Approved, Investigational 15078-28-1 11963622
33
Iron Approved 7439-89-6 23925
34
Cimetidine Approved, Investigational 51481-61-9 2756
35
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
36 Pharmaceutical Solutions Early Phase 1
37 Arginine Vasopressin
38 Liver Extracts
39 glucocorticoids
40 Hydroxycholecalciferols
41 Anabolic Agents
42 Diphosphonates
43 phenylalanine Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 49)

# Name Status NCT ID Phase Drugs
1 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4 25 OH vitamin D
2 A Single Wintertime Dose of Vitamin D3 to Prevent Winter Decline in Vitamin D Status in Healthy Adults Completed NCT01924910 Phase 4
3 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Completed NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
4 Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan Completed NCT02531867 Phase 4
5 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3 osteoanabolic therapy
6 Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP) Completed NCT01176266 Phase 2, Phase 3 asfotase alfa
7 A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia Active, not recruiting NCT03233126 Phase 3 KRN23
8 Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02537431 Phase 3
9 Combination Osteogenic Therapy in Established Osteoporosis Completed NCT00018447 Phase 2 PTH 1-34;MFPSR-fluoride
10 Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP) Completed NCT01163149 Phase 2 asfotase alfa;asfotase alfa
11 Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP) Completed NCT00952484 Phase 2
12 Nursing-Home Residents Given Bread Fortified With Vitamin D3 Completed NCT00789503 Phase 1, Phase 2
13 Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP) Completed NCT01205152 Phase 2
14 Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP) Completed NCT01203826 Phase 2
15 Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP) Completed NCT00744042 Phase 1, Phase 2
16 A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome Active, not recruiting NCT02722798 Phase 2 KRN23
17 Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS) Active, not recruiting NCT02304367 Phase 2 KRN23
18 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Active, not recruiting NCT01967537 Phase 2 68Gallium DOTATATE
19 Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) Withdrawn NCT00894075 Phase 2
20 A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia Completed NCT02181764 Phase 1 KRN23
21 Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP) Completed NCT00739505 Phase 1
22 Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Terminated NCT01748812 Phase 1 Osteomalacia
23 68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia Unknown status NCT01524016 Early Phase 1 68Ga-DOTATATE
24 Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia Unknown status NCT02331966
25 Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP) Approved for marketing NCT02496689
26 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
27 Serum FGF-23 and Vitamin D Deficiency Completed NCT01102751
28 Maternal and Infant Vitamin Status During the First Nine Months of Infant Life Completed NCT02548520
29 Vitamin D, Bones, Nutritional and Cardiovascular Status Completed NCT01832623
30 Does Intravenous Iron Therapy Decrease Serum Phosphorous Levels? Completed NCT02420119
31 Vitamin D Supplementation and Sunlight Exposure in Brazilian Women Living in Opposite Latitudes (The D-SOL Study) Completed NCT03318029
32 APOSTrophe Study (Parenteral Nutrition and Bone Trophicity) Impact of a Long-term Parenteral Nutrition on Bone Metabolism Measured by High Resolution Peripheral Quantitative Computer Tomography (HR-pQCT) in Children and Young Adults Completed NCT02368496
33 Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation Completed NCT01079923
34 The Effect of Vitamin D Repletion on Small Low Density Lipoprotein (LDL) Particle Number in Subjects at Elevated Cardiovascular Risk Completed NCT01008384
35 Replacement of Vitamin D in Patients With Active Tuberculosis Completed NCT01130311 Cholecalciferol;Saline injection
36 Serum Sclerostin Level & Treatment of Vitamin D Deficiency Completed NCT01553344
37 Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism Completed NCT03027349
38 Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09 Completed NCT02235493
39 Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP) Completed NCT02104219
40 A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP) Completed NCT01419028
41 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Recruiting NCT01660308
42 Evaluation and Treatment of Skeletal Diseases Recruiting NCT00024804
43 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
44 The Impact of Severe Vitamin D Deficiency and Its Correction on Bone Mineral Density (BMD) in Postmenopausal Women Recruiting NCT01694355 Vitamin D
45 Hypovitaminosis D Prediction Score Recruiting NCT02822651
46 Natural History Study of Patients With Hypophosphatasia (HPP) Recruiting NCT02237625
47 Vitamin D Level and Risk of Infections in Cirrhotic Patients Recruiting NCT03391245
48 COMPREHENSIVE® REVERSE SHOULDER Mini BasePlate Active, not recruiting NCT02084693
49 Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy Enrolling by invitation NCT02814591

Search NIH Clinical Center for Osteomalacia

Genetic Tests for Osteomalacia

Anatomical Context for Osteomalacia

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomalacia:

18
Bone

MalaCards organs/tissues related to Osteomalacia:

38
Bone, Liver, Kidney, Testes, Prostate, Thyroid, Brain

Publications for Osteomalacia

Articles related to Osteomalacia:

(show top 50) (show all 723)
# Title Authors Year
1
Hypophosphatemic Osteomalacia with Multiple Bone Fractures: ADV-Induced Fanconi's Syndrome. ( 29399572 )
2018
2
Identification of a novel loss-of-function PHEX mutation, Ala720Ser, in a sporadic case of adult-onset hypophosphatemic osteomalacia. ( 28982589 )
2018
3
Occult phosphaturic mesenchymal tumor of femur cortex causing oncogenic osteomalacia: Diagnostic challenges and clinical outcomes. ( 29442350 )
2018
4
Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration. ( 29298794 )
2018
5
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil. ( 29343941 )
2018
6
Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome. ( 29380000 )
2018
7
Oncogenic Osteomalacia. ( 29319792 )
2018
8
Correction to: Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in SjAPgren's syndrome: a case report and review of the literature. ( 29380163 )
2018
9
Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones. ( 28081649 )
2017
10
Tumor-induced osteomalacia. ( 29021995 )
2017
11
A Case of an Insufficiency Fracture of the Medial Proximal Tibia Secondary to Osteomalacia Associated with Long-Term Saccharated Ferric Oxide Administration. ( 28744387 )
2017
12
A distinctive patchy osteomalacia characterises Phospho1-deficient mice. ( 28737011 )
2017
13
Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing. ( 28689456 )
2017
14
Perioperative management of patients with severe hypophosphataemia secondary to oncogenic osteomalacia: Our experience and review of literature. ( 28794533 )
2017
15
Definitive surgical treatment of osteomalacia induced by skull base tumor and determination of the half-life of serum fibroblast growth factor 23. ( 28768937 )
2017
16
Iron Supplementation-Induced Phosphaturic Osteomalacia: FGF23 is the Culprit. ( 29281120 )
2017
17
Musculoskeletal oncogenic osteomalacia-An experience from a single centre in South India. ( 28123260 )
2017
18
Antiepileptic therapy, osteomalacia, and synchronous fractures: Don't lose looser zones. ( 29026776 )
2017
19
Oncogenic osteomalacia: role of Ga-68 DOTANOC PET/CT scan in identifying the culprit lesion and its management. ( 28181822 )
2017
20
Prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures of the femoral head in patients with tumour-induced osteomalacia. ( 28836028 )
2017
21
Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23. ( 28792142 )
2017
22
Peptide Receptor Radionuclide and Octreotide: A Novel Approach for Metastatic Tumor-Induced Osteomalacia. ( 29264524 )
2017
23
Selective blood sampling for FGF-23 in tumor-induced osteomalacia. ( 29026610 )
2017
24
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
25
Nutritional Rickets and Osteomalacia in the Twenty-first Century: Revised Concepts, Public Health, and Prevention Strategies. ( 28612338 )
2017
26
Oncogenic Osteomalacia Secondary to a Metastatic Phosphaturic Mesenchymal Tumor in the Talus: A Case Report and Review of the Literature. ( 29244678 )
2017
27
Atraumatic Bilateral Fracture of the Femoral Neck in Young Male Patient with Suspected Osteomalacia. ( 28955696 )
2017
28
Oncogenic Osteomalacia: An Approach to Diagnosis with a Case Report. ( 28571152 )
2017
29
The Foot That Broke Both Hips: A Case Report and Literature Review of Tumor-Induced Osteomalacia. ( 29104808 )
2017
30
Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma. ( 28719445 )
2017
31
A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report. ( 28953654 )
2017
32
Successful CT guided cryoablation of phosphaturic mesenchymal tumor in the soft tissues causing tumor-induced osteomalacia: a case report. ( 27921126 )
2017
33
Tumour-induced osteomalacia. ( 28703216 )
2017
34
Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients. ( 28934935 )
2017
35
Correction to Oncogenic osteomalacia: role of Ga-68 DOTANOC PET/CT scan in identifying the culprit lesion and its management. ( 29034744 )
2017
36
Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions. ( 27820122 )
2017
37
Hypocalcemia and osteomalacia after bariatric surgery. ( 29263738 )
2017
38
Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. ( 28851305 )
2017
39
Anterior Skull Base Glomangioma-Induced Osteomalacia. ( 28180054 )
2017
40
Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in SjAPgren's syndrome: a case report and review of the literature. ( 28725949 )
2017
41
A case report of phosphaturic mesenchymal tumor-induced osteomalacia. ( 29390586 )
2017
42
Tumour-induced osteomalacia. ( 28703220 )
2017
43
Localization of ectopic fibroblast growth factor 23 production in tumor-induced osteomalacia using selective venous samplings. ( 28025958 )
2017
44
Is there any link between tumor-induced osteomalacia and psoriasis? A case report. ( 28852641 )
2017
45
Pathological fractures in a patient with severe osteomalacia and hyperparathyroidism: a multidisciplinary challenge. ( 28840440 )
2017
46
Adefovir-induced Fanconi syndrome associated with osteomalacia. ( 28859264 )
2017
47
Multimodality Image-Guided Cryoablation for Inoperable Tumor-Induced Osteomalacia. ( 28718983 )
2017
48
Tumor-induced Osteomalacia: A Sherlock Holmes Approach to Diagnosis and Management. ( 28713755 )
2017
49
Tumour-induced osteomalacia: a literature review and a case report. ( 26744291 )
2016
50
Unusual calvarial tumour-oncogenic osteomalacia. ( 27010121 )
2016

Variations for Osteomalacia

Expression for Osteomalacia

Search GEO for disease gene expression data for Osteomalacia.

Pathways for Osteomalacia

GO Terms for Osteomalacia

Cellular components related to Osteomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ALPL BGLAP CALCA FGF23 PTHLH SFRP4
2 extracellular region GO:0005576 9.17 ALPL BGLAP CALCA DMP1 FGF23 PTHLH

Biological processes related to Osteomalacia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.85 CASR NR1I2 SFRP4 VDR
2 cellular protein metabolic process GO:0044267 9.77 CALCA DMP1 FGF23
3 osteoblast differentiation GO:0001649 9.71 ALPL BGLAP CYP24A1
4 cellular calcium ion homeostasis GO:0006874 9.69 CALCA CASR VDR
5 ossification GO:0001503 9.67 BGLAP CASR DMP1
6 skeletal system development GO:0001501 9.65 ALPL BGLAP PHEX PTHLH VDR
7 bone mineralization GO:0030282 9.58 BGLAP PHEX
8 vasodilation GO:0042311 9.58 CALCA CASR
9 regulation of bone mineralization GO:0030500 9.57 BGLAP FGF23
10 osteoblast development GO:0002076 9.56 BGLAP PTHLH
11 vitamin D metabolic process GO:0042359 9.52 CYP24A1 FGF23
12 cellular response to parathyroid hormone stimulus GO:0071374 9.48 FGF23 PHEX
13 phosphate ion homeostasis GO:0055062 9.46 FGF23 SFRP4
14 biomineral tissue development GO:0031214 9.46 ALPL BGLAP DMP1 PHEX
15 vitamin D catabolic process GO:0042369 9.43 CYP24A1 FGF23
16 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.4 FGF23 VDR
17 response to sodium phosphate GO:1904383 9.37 FGF23 PHEX
18 vitamin D receptor signaling pathway GO:0070561 9.32 CYP24A1 VDR
19 response to vitamin D GO:0033280 9.26 ALPL BGLAP CYP24A1 PHEX
20 cellular response to vitamin D GO:0071305 8.92 BGLAP CASR FGF23 PHEX

Molecular functions related to Osteomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.62 NR1I2 VDR

Sources for Osteomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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