MCID: OST011
MIFTS: 49

Osteomalacia malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteomalacia

Aliases & Descriptions for Osteomalacia:

Name: Osteomalacia 12 50 52 14 69
Adult Rickets 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10573
ICD9CM 35 268.2
NCIt 47 C26838
UMLS 69 C0029442

Summaries for Osteomalacia

NIH Rare Diseases : 50 osteomalacia is a disease that is characterized by a weakening of the bone, often due to a deficiency of vitamin d. this vitamin supports the development of the bones of the body, so when there are low levels of vitamin d, the bones are not strong enough. symptoms of osteomalacia can include muscle weakness, bone pain, and walking with a waddling gait. pain is especially likely to occur in the lower back, hips, and legs. the weakening of the bones may also cause them to easily fracture.  osetomalacia can be caused by having a low level of vitamin d in the diet or lack of sun exposure. the condition may also be the result of an underlying disease such as celiac disease, or kidney or liver disorders.  diagnosis of osteomalacia is possible through blood or urine tests to check for vitamin d levels or a bone biopsy. treatment options include supplementing the diet with more vitamin d or calcium. any underlying condition will also need to be treated.   last updated: 9/23/2016

MalaCards based summary : Osteomalacia, also known as adult rickets, is related to axial osteomalacia and hypophosphatasia, adult. An important gene associated with Osteomalacia is DMP1 (Dentin Matrix Acidic Phosphoprotein 1), and among its related pathways/superpathways are G alpha (s) signalling events and Nuclear Receptors in Lipid Metabolism and Toxicity. The drugs Ergocalciferol and Cholecalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A bone remodeling disease that has material basis in a vitamin D deficiency which results_in softening located in bone.

Wikipedia : 71 Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to... more...

Related Diseases for Osteomalacia

Diseases related to Osteomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
id Related Disease Score Top Affiliating Genes
1 axial osteomalacia 33.2 BGLAP CALCA FGF23
2 hypophosphatasia, adult 30.9 BGLAP CALCA PTH
3 oncogenic osteomalacia 12.4
4 rickets 11.2
5 hypophosphatemic rickets 11.1
6 renal osteodystrophy 11.0
7 osteopetrosis 10.7
8 vitamin d-dependent rickets, type i 10.7
9 fanconi renotubular syndrome 1 10.7
10 hypophosphatemic rickets, x-linked dominant 10.7
11 fanconi renotubular syndrome 3 10.7
12 dent disease 10.7
13 nephrolithiasis, type i 10.7
14 hypophosphatemic rickets, ar 10.7
15 fanconi renotubular syndrome 2 10.7
16 hypophosphatemic rickets, autosomal recessive, 2 10.7
17 autosomal recessive hypophosphatemic rickets 10.7
18 slc4a1-associated distal renal tubular acidosis 10.7
19 ventricular tachycardia, catecholaminergic polymorphic, 3 10.3 DMP1 FGF23
20 wiedemann-steiner syndrome 10.3 FGF23 PHEX
21 orbit lymphoma 10.2 FGF23 PTH
22 familial atrial fibrillation 10.2 FGF23 PHEX
23 hyperparathyroidism 10.2
24 lymphangioleiomyomatosis 10.2 DMP1 FGF23 PHEX
25 acute maxillary sinusitis 10.2 DMP1 FGF23 PHEX
26 hypochondrogenesis 10.2 BGLAP PTH
27 x-linked hereditary ataxia 10.2 DMP1 FGF23 PHEX
28 feigenbaum bergeron richardson syndrome 10.2 FGF23 PHEX
29 epilepsy, idiopathic generalized 14 10.2 BGLAP FGF23
30 fanconi syndrome 10.2
31 peroxisome biogenesis disorder 2b 10.2 FGF23 PHEX SFRP4
32 progressive locomotor ataxia 10.2 FGF23 PTHLH
33 malignant granular cell myoblastoma 10.2 PTH PTHLH
34 joubert syndrome 9 10.1 FGF23 PTH
35 striatonigral degeneration 10.1 CASR PTH
36 primary release disorder of platelets 10.1 BGLAP PTHLH
37 mixed germ cell cancer 10.1 PTH PTHLH
38 chronic myocardial ischemia 10.1 FGF23 PTH VDR
39 prediabetes syndrome 10.1 BGLAP FGF23 PTH
40 osteoporosis 10.1
41 familial chronic myelocytic leukemia-like syndrome 10.1 CASR PTH
42 deafness, nonsyndromic, modifier 1 10.1 CASR VDR
43 cerebrooculofacioskeletal syndrome 4 10.1 CASR PTHLH
44 y chromosome detection 10.1 BGLAP PTH VDR
45 prostate cancer, hereditary, x-linked 2 10.1 DMP1 FGF23 PHEX VDR
46 stickler syndrome 10.0 CALCA PTH
47 pterygium, antecubital 10.0 PTHLH SFRP4
48 renal tubular acidosis 10.0
49 impotence 10.0 PTH PTHLH
50 bile duct mucoepidermoid carcinoma 10.0 CASR PTH VDR

Comorbidity relations with Osteomalacia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Osteoporosis

Graphical network of the top 20 diseases related to Osteomalacia:



Diseases related to Osteomalacia

Symptoms & Phenotypes for Osteomalacia

MGI Mouse Phenotypes related to Osteomalacia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.09 CASR CYP24A1 DMP1 FGF23 PHEX PTH
2 homeostasis/metabolism MP:0005376 10.07 CASR CYP24A1 DMP1 FGF23 NR1I2 PHEX
3 hematopoietic system MP:0005397 10.01 CASR DMP1 FGF23 PHEX PTH PTHLH
4 digestive/alimentary MP:0005381 9.93 SFRP4 VDR CASR FGF23 PHEX PTHLH
5 immune system MP:0005387 9.92 CASR DMP1 FGF23 PHEX PTH PTHLH
6 craniofacial MP:0005382 9.88 DMP1 PHEX PTH PTHLH VDR
7 mortality/aging MP:0010768 9.81 CASR CYP24A1 FGF23 NR1I2 PHEX PTH
8 limbs/digits/tail MP:0005371 9.8 PHEX PTH PTHLH SFRP4 VDR DMP1
9 renal/urinary system MP:0005367 9.56 CASR CYP24A1 DMP1 FGF23 PHEX PTHLH
10 skeleton MP:0005390 9.28 CASR CYP24A1 DMP1 FGF23 PHEX PTH

Drugs & Therapeutics for Osteomalacia

Drugs for Osteomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
2
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
3
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
4 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2
5 Ergocalciferols Phase 4,Phase 1,Phase 2
6 Micronutrients Phase 4,Phase 1,Phase 2
7 Trace Elements Phase 4,Phase 1,Phase 2
8 vitamin d Phase 4,Phase 1,Phase 2
9 Vitamins Phase 4,Phase 1,Phase 2
10 Hormones Phase 4,Phase 1
11 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
12 Immunoglobulin G Phase 4,Phase 3,Phase 2,Phase 1
13 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
14 Retinol palmitate Phase 4
15 Calciferol Nutraceutical Phase 4,Phase 1,Phase 2
16 Vitamin D2 Nutraceutical Phase 4,Phase 1,Phase 2
17 retinol Nutraceutical Phase 4
18
Teriparatide Approved, Investigational Phase 3 52232-67-4 16133850
19 Mitogens Phase 3,Phase 2,Phase 1
20 Antibodies, Monoclonal Phase 3,Phase 2
21
Somatostatin Approved Phase 2,Early Phase 1 38916-34-6, 51110-01-1 53481605
22 Cariostatic Agents Phase 2
23 Fluorides Phase 2
24 Protective Agents Phase 2
25 Calcifediol Phase 1, Phase 2 19356-17-3
26 Calcium, Dietary Phase 1, Phase 2
27 Calcimimetic Agents Phase 1
28 Cinacalcet Hydrochloride Phase 1
29 Hormone Antagonists Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
31
Acetylcholine Approved 51-84-3 187
32
Nitroprusside Approved 15078-28-1 11963622
33
Iron Approved 7439-89-6 23925
34
Menthol Approved Early Phase 1 2216-51-5 16666
35
Cimetidine Approved 51481-61-9 2756
36 Arginine Vasopressin
37 Liver Extracts
38 Pharmaceutical Solutions Early Phase 1
39 glucocorticoids
40 Anabolic Agents
41 Diphosphonates
42 Hydroxycholecalciferols
43 phenylalanine Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density Completed NCT01025128 Phase 4
2 Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan Completed NCT02531867 Phase 4
3 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Recruiting NCT02238418 Phase 4
4 A Single Wintertime Dose of Vitamin D3 to Prevent Winter Decline in Vitamin D Status in Healthy Adults Active, not recruiting NCT01924910 Phase 4
5 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3
6 Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02537431 Phase 3
7 Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP) Active, not recruiting NCT01176266 Phase 2, Phase 3
8 Combination Osteogenic Therapy in Established Osteoporosis Completed NCT00018447 Phase 2
9 Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP) Completed NCT01163149 Phase 2
10 Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP) Completed NCT00952484 Phase 2
11 Nursing-Home Residents Given Bread Fortified With Vitamin D3 Completed NCT00789503 Phase 1, Phase 2
12 Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP) Completed NCT01205152 Phase 2
13 Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP) Completed NCT01203826 Phase 2
14 Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP) Completed NCT00744042 Phase 1, Phase 2
15 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Recruiting NCT01967537 Phase 2
16 A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome Active, not recruiting NCT02722798 Phase 2
17 Study of KRN23 in Adult Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS) Active, not recruiting NCT02304367 Phase 2
18 Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) Withdrawn NCT00894075 Phase 2
19 A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia Completed NCT02181764 Phase 1
20 Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP) Completed NCT00739505 Phase 1
21 Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Terminated NCT01748812 Phase 1
22 Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia Unknown status NCT02331966
23 Vitamin D, Bones, Nutritional and Cardiovascular Status Unknown status NCT01832623
24 Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP) Approved for marketing NCT02496689
25 Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia Completed NCT00099762
26 Serum FGF-23 and Vitamin D Deficiency Completed NCT01102751
27 Maternal and Infant Vitamin Status During the First Nine Months of Infant Life Completed NCT02548520
28 Does Intravenous Iron Therapy Decrease Serum Phosphorous Levels? Completed NCT02420119
29 Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation Completed NCT01079923
30 The Effect of Vitamin D Repletion on Small Low Density Lipoprotein (LDL) Particle Number in Subjects at Elevated Cardiovascular Risk Completed NCT01008384
31 APOSTrophe Study (Parenteral Nutrition and Bone Trophicity) Impact of a Long-term Parenteral Nutrition on Bone Metabolism Measured by High Resolution Peripheral Quantitative Computer Tomography (HR-pQCT) in Children and Young Adults Completed NCT02368496
32 Replacement of Vitamin D in Patients With Active Tuberculosis Completed NCT01130311
33 Serum Sclerostin Level & Treatment of Vitamin D Deficiency Completed NCT01553344
34 Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism Completed NCT03027349
35 Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09 Completed NCT02235493
36 Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP) Completed NCT02104219
37 A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP) Completed NCT01419028
38 68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia Recruiting NCT01524016 Early Phase 1
39 Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia Recruiting NCT01660308
40 Evaluation and Treatment of Skeletal Diseases Recruiting NCT00024804
41 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
42 The Impact of Severe Vitamin D Deficiency and Its Correction on Bone Mineral Density (BMD) in Postmenopausal Women Recruiting NCT01694355
43 Natural History Study of Patients With Hypophosphatasia (HPP) Recruiting NCT02237625
44 COMPREHENSIVE® REVERSE SHOULDER Mini BasePlate Active, not recruiting NCT02084693
45 Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy Enrolling by invitation NCT02814591
46 Hypovitaminosis D Prediction Score Not yet recruiting NCT02822651

Search NIH Clinical Center for Osteomalacia

Genetic Tests for Osteomalacia

Anatomical Context for Osteomalacia

MalaCards organs/tissues related to Osteomalacia:

39
Bone, Kidney, Testes, Liver, Prostate, Thyroid, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomalacia:

18
Bone

Publications for Osteomalacia

Articles related to Osteomalacia:

(show top 50) (show all 680)
id Title Authors Year
1
Localization of ectopic fibroblast growth factor 23 production in tumor-induced osteomalacia using selective venous samplings. ( 28025958 )
2017
2
Successful CT guided cryoablation of phosphaturic mesenchymal tumor in the soft tissues causing tumor-induced osteomalacia: a case report. ( 27921126 )
2017
3
Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones. ( 28081649 )
2017
4
Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions. ( 27820122 )
2017
5
Needle(s) in the Haystack-Synchronous Multifocal Tumor-Induced Osteomalacia. ( 26691889 )
2016
6
Unusual calvarial tumour-oncogenic osteomalacia. ( 27010121 )
2016
7
Dramatic mitigation of bone pain after phosphorus replacement therapy in a subject with FGF23-related hypophosphatemic osteomalacia. ( 27867811 )
2016
8
(68)Ga-DOTATATE for Tumor Localization in Tumor-induced Osteomalacia. ( 27533306 )
2016
9
Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum: A case report. ( 27141918 )
2016
10
Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660). ( 27862258 )
2016
11
The hypoxia-inducible factor-1I+ activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia. ( 27468359 )
2016
12
Symptomatic hypophosphataemic osteomalacia secondary to the treatment with iron carboxymaltose detected in bone scintigraphy. ( 27246291 )
2016
13
Urinary I^-2 Microglobulin Levels Sensitively Altered in an Osteomalacia Patient Receiving Add-on Adefovir Dipivoxil Therapy for Hepatitis B Virus Infection. ( 27301512 )
2016
14
Multiple Looser zones of osteomalacia in Byler disease with associated vitamin D deficiency, phosphaturia, and elevated FGF23. ( 26771453 )
2016
15
'Rachitic rosary sign' and 'tie sign' of the sternum in tumour-induced osteomalacia. ( 26907825 )
2016
16
Oncogenic hypophosphatemic osteomalacia: From the first signal of disease to the first signal of healthy. ( 28012328 )
2016
17
Idiopathic hypophosphatemic osteomalacia: recurrent pseudofracture of the proximal femur in a 65-year-old man. ( 27995499 )
2016
18
Quantitative ELISA-Like Immunohistochemistry of Fibroblast Growth Factor 23 in Diagnosis of Tumor-Induced Osteomalacia and Clinical Characteristics of the Disease. ( 27034530 )
2016
19
Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. ( 26721590 )
2016
20
Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors. ( 27664568 )
2016
21
Diagnostic importance of contrast enhanced (18)F-fluorodeoxyglucose positron emission computed tomography in patients with tumor induced osteomalacia: Our experience. ( 26917888 )
2016
22
Bone Histology of Two Cases with Osteomalacia Related to Low-dose Adefovir. ( 27746441 )
2016
23
Osteomalacia with low alkaline phosphatase: a not so rare condition with important consequences. ( 26823351 )
2016
24
Hypophosphatemic osteomalacia: a case simulating anklylosing spondylitis treated with anti-TNF therapy. ( 27620624 )
2016
25
An Adult Male With Hypophosphatemic Osteomalacia. ( 27261876 )
2016
26
Rickets and osteomalacia: a call for action to protect immigrants and ethnic risk groups. ( 27013305 )
2016
27
Primary hyperparathyroidism may masquerade as rickets-osteomalacia in vitamin D replete children. ( 27710917 )
2016
28
Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum. ( 27994603 )
2016
29
Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy. ( 27754732 )
2016
30
Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: case report. ( 26722864 )
2016
31
FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma: A Case Report and Regulatory Mechanism Study. ( 26612848 )
2016
32
177Lu-DOTATATE PRRT as promising new treatment approach in Recurrent Skull Base Phosphaturic Mesenchymal Tumor causing paraneoplastic oncogenic osteomalacia: a potential therapeutic application of PRRT beyond NET. ( 27634982 )
2016
33
A feasibility study of educational tools for osteomalacia. ( 27785646 )
2016
34
Osteomalacia by a mesenchymal-FGF23-producing tumour: Successful treatment with radiofrequency ablation. A case report. ( 27006265 )
2016
35
Tumour-induced osteomalacia: An emergent paraneoplastic syndrome. ( 26718193 )
2016
36
Reports of 17 Chinese patients with tumor-induced osteomalacia. ( 27085966 )
2016
37
"Slow and steady wins the race": the importance of perseverance in the management of oncogenic osteomalacia. ( 27900654 )
2016
38
Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia. ( 27150801 )
2016
39
Tumour-induced osteomalacia: a literature review and a case report. ( 26744291 )
2016
40
Missed causative tumors in diagnosing tumor-induced osteomalacia with (18)F-FDG PET/CT: a potential pitfall of standard-field imaging. ( 26929940 )
2016
41
Proximal muscle weakness as a result of osteomalacia associated with celiac disease: a case report. ( 26310636 )
2015
42
Oncogenic osteomalacia caused by an occult paranasal sinus tumor. ( 25682388 )
2015
43
Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones: Seventeen Cases with More Than One Year of Follow-up. ( 26135075 )
2015
44
Osteomalacia as a Cause of Chronic Low Back and Buttock Pain. ( 26135370 )
2015
45
Osteomalacia, severe thoracic deformities and respiratory failure in a young woman with anorexia nervosa. ( 25876575 )
2015
46
Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil. ( 25721615 )
2015
47
Utility of Gallium-68 DOTANOC PET/CT in the localization of Tumour-induced osteomalacia. ( 25996566 )
2015
48
Pathogenesis and diagnostic criteria for rickets and osteomalacia--proposal by an expert panel supported by the Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research, and the Japan Endocrine Society. ( 26197863 )
2015
49
Osteomalacia and coxa vara. An unusual co-existence for femoral neck stress fracture. ( 26454499 )
2015
50
Locally aggressive and multifocal phosphaturic mesenchymal tumors: two unusual cases of tumor-induced osteomalacia. ( 26341245 )
2015

Variations for Osteomalacia

Expression for Osteomalacia

Search GEO for disease gene expression data for Osteomalacia.

Pathways for Osteomalacia

GO Terms for Osteomalacia

Cellular components related to Osteomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 BGLAP CALCA DMP1 FGF23 PTH PTHLH
2 extracellular space GO:0005615 9.1 BGLAP CALCA FGF23 PTH PTHLH SFRP4

Biological processes related to Osteomalacia according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 CASR NR1I2 SFRP4 VDR
2 cell-cell signaling GO:0007267 9.86 CALCA PHEX PTH PTHLH
3 cellular protein metabolic process GO:0044267 9.8 CALCA DMP1 FGF23
4 ossification GO:0001503 9.74 BGLAP CASR DMP1
5 positive regulation of cAMP biosynthetic process GO:0030819 9.69 CALCA PTH PTHLH
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.67 CALCA PTH PTHLH
7 bone mineralization GO:0030282 9.62 BGLAP PHEX
8 vasodilation GO:0042311 9.62 CALCA CASR
9 regulation of bone mineralization GO:0030500 9.61 BGLAP FGF23
10 osteoblast development GO:0002076 9.61 BGLAP PTHLH
11 negative regulation of chondrocyte differentiation GO:0032331 9.6 PTH PTHLH
12 positive regulation of ossification GO:0045778 9.59 CALCA PTH
13 vitamin D metabolic process GO:0042359 9.58 CYP24A1 FGF23
14 cellular calcium ion homeostasis GO:0006874 9.56 CALCA CASR PTH VDR
15 cellular response to parathyroid hormone stimulus GO:0071374 9.55 FGF23 PHEX
16 skeletal system development GO:0001501 9.55 BGLAP PHEX PTH PTHLH VDR
17 response to fibroblast growth factor GO:0071774 9.54 CASR PTH
18 phosphate ion homeostasis GO:0055062 9.52 FGF23 SFRP4
19 biomineral tissue development GO:0031214 9.5 BGLAP DMP1 PHEX
20 cAMP metabolic process GO:0046058 9.48 PTH PTHLH
21 vitamin D catabolic process GO:0042369 9.46 CYP24A1 FGF23
22 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.43 FGF23 VDR
23 response to sodium phosphate GO:1904383 9.4 FGF23 PHEX
24 vitamin D receptor signaling pathway GO:0070561 9.37 CYP24A1 VDR
25 response to vitamin D GO:0033280 9.26 BGLAP CYP24A1 PHEX PTH
26 cellular response to vitamin D GO:0071305 8.92 BGLAP CASR FGF23 PHEX

Molecular functions related to Osteomalacia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 NR1I2 VDR
2 hormone activity GO:0005179 9.13 CALCA PTH PTHLH
3 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Osteomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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