MCID: OST017
MIFTS: 61

Osteomyelitis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Osteomyelitis

Aliases & Descriptions for Osteomyelitis:

Name: Osteomyelitis 12 50 29 52 14 69

Classifications:



Summaries for Osteomyelitis

NIH Rare Diseases : 50 osteomyelitis is the medical term for an infection in a bone. signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. people with the condition may also experience local swelling, redness, and warmth at the site of the infection. although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. the goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. this may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue. last updated: 10/19/2016

MalaCards based summary : Osteomyelitis is related to orbital osteomyelitis and tuberculosis, and has symptoms including pain in limb and bone pain. An important gene associated with Osteomyelitis is IFNGR1 (Interferon Gamma Receptor 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ciprofloxacin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 71 Osteomyelitis (OM) is infection and inflammation of the bone. It can be usefully subclassified on the... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 539)
id Related Disease Score Top Affiliating Genes
1 orbital osteomyelitis 32.6 IFNG IL10 IL6 TNF TNFSF11
2 tuberculosis 30.0 IL10 IL1B IL6 TNF
3 meningitis 29.6 CXCL8 IL1A IL6 TNF
4 neuropathy 29.6 CXCL8 IL1B IL6 TNF
5 pyelonephritis 29.5 CXCL8 IL10 IL1B TNF
6 stomatitis 29.5 CXCL8 IL1RN IL6
7 pyoderma gangrenosum 29.4 CXCL8 IFNG IL1B IL6 TNF
8 osteonecrosis 29.3 CXCL8 IL1B IL6 TNF TNFSF11
9 labyrinthitis 28.9 CXCL8 IL10 IL1B IL6 TNF
10 anaplastic large cell lymphoma 28.8 IFNG IL1A TNF
11 exophthalmos 28.8 CXCL8 IFNG IL10 IL1B IL6 TNF
12 nasopharyngitis 28.7 CXCL8 IFNG IL1A IL1B IL6 TNF
13 histiocytosis 28.3 CXCL8 IL1A IL1B IL1RN IL6 TNF
14 rheumatoid arthritis 27.7 ACP5 CTSK CXCL8 IFNG IL10 IL1A
15 chronic recurrent multifocal osteomyelitis 12.5
16 majeed syndrome 11.8
17 sapho syndrome 11.5
18 interleukin 1 receptor antagonist deficiency 11.5
19 mycobacterium fortuitum 11.0
20 petrositis 11.0
21 neuropathy, hereditary sensory, type if 10.8
22 neuropathy, hereditary sensory and autonomic, type ic 10.8
23 phaeohyphomycosis 10.7
24 mitochondrial dna depletion syndrome 6 10.7
25 gnathodiaphyseal dysplasia 10.7
26 psoriasis 14, pustular 10.7
27 amyloidosis aa 10.7
28 neuropathy, hereditary sensory and autonomic, type iib 10.7
29 immunodeficiency 27b, mycobacteriosis, ad 10.7
30 insensitivity to pain, congenital, with anhidrosis 10.7
31 neuropathy, hereditary sensory and autonomic, type ia 10.7
32 intussusception 10.3 IL1B TNF
33 mental retardation, autosomal dominant 22 10.3 CASP1 IL1B IL1RN
34 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
35 intravascular papillary endothelial hyperplasia 10.3 IFNG IFNGR1
36 rosacea 10.3 IFNG IL10 IL1B
37 urea cycle disorder 10.3 IL10 IL1B IL6
38 warthin tumor 10.2 IL1B IL1RN TNF
39 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
40 lepromatous leprosy 10.2 IFNG IL10 IL6
41 stocco dos santos syndrome 10.2 IFNG IL1B TNF
42 breast reconstruction 10.2 IL10 IL1B IL6
43 bipolar i disorder 10.2 IL1B IL6 TNF
44 multiple mitochondrial dysfunctions syndrome 10.2 IFNG IL10 IL6
45 human immunodeficiency virus infectious disease 10.2 IL1B IL6 TNF
46 tinea capitis 10.2 IL1B IL6 TNF
47 stiff-person syndrome 10.2 IFNG IL1RN IL6
48 measles 10.2 IL1B IL6 TNF
49 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
50 pyloric stenosis, infantile hypertrophic, 2 10.2 CASP1 IL1B TNF

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


pain in limb, bone pain

MGI Mouse Phenotypes related to Osteomyelitis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.39 IL1A IL1B IL1RN IL6 LPIN2 PPP3CA
2 homeostasis/metabolism MP:0005376 10.37 IFNGR1 IL10 IL1A IL1B IL1RN IL6
3 cardiovascular system MP:0005385 10.35 ALPL BMP2 CASP1 IFNG IFNGR1 IL10
4 immune system MP:0005387 10.35 ALPL BMP2 CASP1 CTSK IFNG IFNGR1
5 cellular MP:0005384 10.27 ALPL BMP2 CASP1 CTSK IFNG IFNGR1
6 growth/size/body region MP:0005378 10.26 ALPL BMP2 CTSK IFNG IL10 IL1RN
7 mortality/aging MP:0010768 10.22 ALPL BMP2 CASP1 IFNG IFNGR1 IL10
8 digestive/alimentary MP:0005381 10.2 ALPL BMP2 CASP1 CTSK IFNG IFNGR1
9 endocrine/exocrine gland MP:0005379 10.19 ALPL CASP1 CTSK IFNG IFNGR1 IL10
10 integument MP:0010771 10.16 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
11 craniofacial MP:0005382 10.1 ALPL BMP2 CTSK IFNG IL10 TNF
12 nervous system MP:0003631 10.03 IL1B IL6 LPIN2 PPP3CA TNF ALPL
13 neoplasm MP:0002006 9.97 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
14 limbs/digits/tail MP:0005371 9.91 ALPL BMP2 CTSK IL10 TNF TNFSF11
15 muscle MP:0005369 9.91 ALPL IFNG IL10 IL6 PPP3CA TNF
16 reproductive system MP:0005389 9.85 IFNGR1 IL10 IL1RN IL6 TNF TNFSF11
17 respiratory system MP:0005388 9.5 IFNG IL10 IL6 TNF TNFSF11 ALPL
18 skeleton MP:0005390 9.36 TNF TNFSF11 ALPL BMP2 CTSK IFNG

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Early Phase 1 85721-33-1 2764
2
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 738-70-5 5578
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1404-90-6 441141 14969
6
Cefepime Approved Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
7
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 456256 5742673
8
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
9
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
10
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
11
Fusidic Acid Approved Phase 4,Phase 2,Phase 3 6990-06-3 3000226
12
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
13
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
14
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
15
Rifampin Approved Phase 4,Early Phase 1 13292-46-1 5458213 5381226
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 58-05-9 54575, 6560146 143
18
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Antitubercular Agents Phase 4,Phase 3,Phase 2,Early Phase 1
23 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
24 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
25 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
26 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Early Phase 1
27 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
28 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
29 Renal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
30 Topoisomerase Inhibitors Phase 4,Phase 2,Early Phase 1
31 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Phase 2,Early Phase 1
32 Vitamin B Complex Phase 4,Phase 3,Phase 2,Early Phase 1
33 methicillin Phase 4,Phase 3,Early Phase 1
34 Cytochrome P-450 CYP3A Inducers Phase 4,Early Phase 1
35 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
36 Gentamicins Phase 4,Early Phase 1
37 Cephalosporins Phase 4,Phase 1,Phase 2
38 Dermatologic Agents Phase 4
39 Micronutrients Phase 4
40 Photosensitizing Agents Phase 4
41 Trace Elements Phase 4
42 Vitamins Phase 4
43 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
44 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
45 Vitamin B2 Nutraceutical Phase 4
46
Amoxicillin Approved, Vet_approved Phase 3,Early Phase 1 26787-78-0 33613 2171
47
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
48
Nafcillin Approved Phase 3,Phase 2,Early Phase 1 985-16-0, 147-52-4 8982
49
Ertapenem Approved, Investigational Phase 3 153832-46-3 150610
50
Minocycline Approved, Investigational Phase 3,Early Phase 1 10118-90-8 5281021

Interventional clinical trials:

(show top 50) (show all 84)
id Name Status NCT ID Phase
1 Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J) Unknown status NCT00974493 Phase 4
2 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4
3 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4
4 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Recruiting NCT02128256 Phase 4
5 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Not yet recruiting NCT03012529 Phase 4
6 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Not yet recruiting NCT03112356 Phase 4
7 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4
8 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
9 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4
10 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
11 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3
12 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3
13 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3
14 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
15 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3
16 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Recruiting NCT03174366 Phase 3
17 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3
18 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Recruiting NCT02569541 Phase 2, Phase 3
19 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3
20 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
21 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci Completed NCT00428844 Phase 2
22 Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Recruiting NCT03091439 Phase 2
23 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis Recruiting NCT02168816 Phase 2
24 Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Subjects With Osteomyelitis Recruiting NCT02685033 Phase 2
25 Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Recruiting NCT02335905 Phase 1, Phase 2
26 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Recruiting NCT02594878 Phase 2
27 Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration Recruiting NCT02842619 Phase 1, Phase 2
28 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2
29 [124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection Terminated NCT01764919 Phase 2
30 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
31 Drug Penetration Into Bone After Repeated Oral Administration of Debio 1450 to Patients Undergoing Hip Replacement Surgery Recruiting NCT02726438 Phase 1
32 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Unknown status NCT02165579
33 Detection of Osteomyelitis Using High Resolution Ultrasound Unknown status NCT02198755
34 Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus (MRSA) Osteomyelitis (VOTSMO) Unknown status NCT00324922
35 Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903
36 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979
37 Characterizing and Diagnosis’s of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients Unknown status NCT00157222
38 Instant Total Contact Cast to Heal Diabetic Foot Ulcers Unknown status NCT01221207
39 Clinical Evaluation of Daptomycin Bone Penetration Unknown status NCT01306825
40 Computed Tomography (CT) Score and Histopathology of the Middle Turbinate in Chronic Rhinosinusitis Unknown status NCT00899561
41 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT) Completed NCT02308774
42 Characterization and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
43 Risk Factors for Three Critical Stages of the Diabetic Foot Infections Completed NCT02736253
44 Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ Completed NCT01670422
45 Drug Delivery Devices for Osteomyelitis Completed NCT02968693
46 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
47 Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections Completed NCT02311452
48 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
49 Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients` Clinical Outcome in Orthopedic Device Related Bone Infections Completed NCT02971657
50 Bisphosphonate-Associated Jaw Osteonecrosis and PET Imaging Completed NCT00592982

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

id Genetic test Affiliating Genes
1 Osteomyelitis 29

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

39
Bone, Bone Marrow, Spinal Cord, Testes, Skin, T Cells, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

18
Bone Or

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 1323)
id Title Authors Year
1
Two stage management of Cierny-Mader type IV chronic osteomyelitis of the long bones. ( 28088375 )
2017
2
An uncommon cause of sciatic pain: tuberculous osteomyelitis of the ischial tuberosity. ( 28074705 )
2017
3
Clostridium sphenoides Chronic Osteomyelitis Diagnosed Via Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, Conflicting With 16S rRNA Sequencing but Confirmed by Whole Genome Sequencing. ( 28051992 )
2017
4
Multifocal Recurrent Osteomyelitis and Hemophagocytic Lymphohistiocytosis in a Boy with Partial Dominant IFN-I^R1 Deficiency: Case Report and Review of the Literature. ( 28516082 )
2017
5
Detecting chronic post-traumatic osteomyelitis of mouse tibia via an IL-13RI+2 targeted metallofullerene magnetic resonance imaging probe. ( 28061526 )
2017
6
Blood perfusion in osteomyelitis studied with [(15)O]water PET in a juvenile porcine model. ( 28091979 )
2017
7
Arthrocladium fulminans Arthritis and Osteomyelitis. ( 28070004 )
2017
8
Persistent Fever in Medical Intensive Care Unit: Evans Syndrome Versus Actinomycotic Osteomyelitis? ( 28092284 )
2017
9
Primary subacute epiphyseal osteomyelitis caused by Mycobacterium species in young children: a modern diagnostic approach. ( 28054229 )
2017
10
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
11
Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats. ( 28064219 )
2017
12
Staphylococcus lugdunensis: An Underreported Pathogen in Osteomyelitis. ( 28073654 )
2017
13
Salmonella pyomyositis with concurrent sacroiliac osteomyelitis presenting as piriformis syndrome: A rare case. ( 27779154 )
2017
14
Salmonella Enterica Serotype Enteritidis Vertebral Osteomyelitis and Epidural Abscess Complicated with Meningitis. ( 27628612 )
2016
15
Salmonella pyomyositis with concurrent osteomyelitis presenting as piriformis syndrome. ( 27727757 )
2016
16
An investigation into blood microbiota and its potential association with Bacterial Chondronecrosis with Osteomyelitis (BCO) in Broilers. ( 27174843 )
2016
17
Chronic Recurrent Multifocal Osteomyelitis in Crohn's Disease - Complete Resolution with Anti TNFI+ Therapy. ( 27050047 )
2016
18
Lumbar spine osteomyelitis and epidural abscess formation secondary to acupuncture. ( 26976275 )
2016
19
Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. ( 27576444 )
2016
20
MRI of acute osteomyelitis in long bones of children: Pathophysiology study. ( 27641643 )
2016
21
Fronto-orbital tuberculous osteomyelitis with temporalis myositis. ( 27153182 )
2016
22
Oral Rehabilitation of an Osteopetrosis Patient with Osteomyelitis. ( 27148461 )
2016
23
Osteomyelitis Because of Mycobacterium Xenopi in an Immunocompetent Child. ( 26418244 )
2016
24
The Possible Role of Dental Implants in the Etiology and Prognosis of Osteomyelitis: A Retrospective Study. ( 27632266 )
2016
25
Life-threatening MRSA sepsis with bilateral pneumonia, osteomyelitis, and septic arthritis of the knee in a previously healthy 13-year-old boy: a case report. ( 27867536 )
2016
26
Combining in vitro protein detection and in vivo antibody detection identifies potential vaccine targets against Staphylococcus aureus during osteomyelitis. ( 27629411 )
2016
27
Delayed diagnosis of central skull-base osteomyelitis with abscess: case report and learning points. ( 27659382 )
2016
28
Candidal Vertebral Osteomyelitis in the Midst of Renal Disorders. ( 27190806 )
2016
29
Fibula extension and correction of foot and ankle deformity to rectify post-osteomyelitis talipes equinovarus in a young adult: a case report and literature review. ( 27383298 )
2016
30
Osteomyelitis of Humerus and Intramuscular Abscess Due to Melioidosis. ( 28166079 )
2016
31
Numb chin syndrome as initial manifestation of bisphosphonate-related osteomyelitis of the jaw and methotrexate-associated lymphoproliferative disorders: a rare case. ( 26608686 )
2016
32
Anaplastic large cell lymphoma masquerading as osteomyelitis of the shoulder: an uncommon presentation. ( 28003232 )
2016
33
Ferumoxytol negatively enhances T2 -weighted MRI of pedal osteomyelitis in vivo. ( 27654009 )
2016
34
Epigenetic Modification Mediates the Increase of LAG-3(+) T Cells in Chronic Osteomyelitis. ( 28028751 )
2016
35
Concomitant Suppurative Parotitis and Condylar Osteomyelitis. ( 27717819 )
2016
36
Fusarium Osteomyelitis in a Patient With Pearson Syndrome: Case Report and Review of the Literature. ( 27757410 )
2016
37
Correction: Lumbosacral Osteomyelitis and Discitis with Phlegmon Following Laparoscopic Sacral Colpopexy. ( 27766189 )
2016
38
Successful treatment of chronic osteomyelitis in children with debridement, antibiotic-laden cement spacer and bone graft substitute. ( 27644427 )
2016
39
Maxillary Osteomyelitis: A Rare Entity. ( 27648332 )
2016
40
Treatment of post-traumatic chronic osteomyelitis of lower limbs by bone transport technique using mono-lateral external fixator: Follow-up study of 18 cases. ( 27192927 )
2016
41
Mandibular osteomyelitis after group A streptococcal septicaemia in a child. ( 27633906 )
2016
42
Chronic suppurative osteomyelitis with proliferative periostitis related to a fully impacted third molar germ: a report of two cases. ( 27595089 )
2016
43
Brachial Plexus Palsy in Young Infants Harboring Osteomyelitis of the Humerus - Case Report and Review of the Literature. ( 28033242 )
2016
44
Delay in Diagnosis of Vertebral Osteomyelitis Affects the Utility of Cultures. ( 27608747 )
2016
45
Mycobacterium bovis Bacillus Calmette-GuAcrin vaccination-associated osteomyelitis, arthritis, and tenosynovitis on the thumb of a 2-year-old boy. ( 27271355 )
2016
46
Mycobacterial Osteomyelitis of the Spine Following Intravesical BCG Therapy for Bladder Cancer. ( 27158574 )
2016
47
Vertebral Osteomyelitis and Acinetobacter Spp. Paravertebral Soft Tissue Infection in a 4 Year-Old Boy with X-Linked Chronic Granulomatous Disease. ( 27182896 )
2016
48
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report. ( 27662446 )
2016
49
Chronic recurrent multifocal osteomyelitis with isolated spinal involvement. ( 27156159 )
2016
50
Isolated tubercular osteomyelitis of acromion: A case report and review of literature. ( 28018073 )
2016

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CASP1 CTSK CXCL8 IFNG IFNGR1 IL10
2
Show member pathways
13.74 BMP2 CASP1 CXCL8 IFNG IFNGR1 IL10
3
Show member pathways
13.6 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
4
Show member pathways
13.47 BMP2 CXCL8 IL10 IL1A IL1B IL6
5
Show member pathways
13.46 CASP1 CXCL8 IFNG IFNGR1 IL10 IL1A
6
Show member pathways
13.39 BMP2 CASP1 CXCL8 IL10 IL1A IL1B
7
Show member pathways
13.23 IFNG IFNGR1 IL1A IL1B PPP3CA TNF
8
Show member pathways
13.1 CASP1 CXCL8 IL1A IL1B IL1RN IL6
9
Show member pathways
13.03 CTSK CXCL8 IFNG IFNGR1 IL10 IL1B
10
Show member pathways
12.96 CXCL8 IFNG IL10 IL1A IL1B IL6
11
Show member pathways
12.93 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
12
Show member pathways
12.82 CASP1 CXCL8 IFNG IL1B IL6 TNF
13 12.78 CASP1 IL1A IL1B PPP3CA TNF
14
Show member pathways
12.76 BMP2 IL1A IL1B IL6 TNF
15
Show member pathways
12.73 IFNG IFNGR1 IL1A IL1B TNF
16
Show member pathways
12.72 IFNG IFNGR1 IL10 IL1A IL1B IL6
17
Show member pathways
12.71 CASP1 IL1A IL1B PPP3CA TNF TNFSF11
18
Show member pathways
12.7 IFNG IFNGR1 IL10 PPP3CA TNF
19 12.68 IFNG IL10 IL1B IL1RN PPP3CA TNF
20
Show member pathways
12.66 IFNG IL10 IL1B IL6 TNF
21
Show member pathways
12.57 IFNG IL10 IL1A IL1B IL6 PPP3CA
22
Show member pathways
12.49 ACP5 CTSK IL10 PPP3CA TNFSF11
23
Show member pathways
12.43 CXCL8 IFNG IL1B IL6 TNF
24
Show member pathways
12.4 IFNG IFNGR1 IL10 IL1A IL1B TNF
25
Show member pathways
12.39 IFNG IL1B IL6 TNF
26
Show member pathways
12.39 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
27
Show member pathways
12.36 CASP1 IL1A IL1B IL1RN
28
Show member pathways
12.34 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
29
Show member pathways
12.33 CXCL8 IL1A IL6 TNF
30 12.29 CXCL8 IL10 IL1A IL1B IL1RN IL6
31
Show member pathways
12.28 IFNG IFNGR1 IL10 IL6
32
Show member pathways
12.26 CXCL8 IFNG IL10 IL1A IL1B IL6
33 12.26 IFNG IFNGR1 IL10 IL1A IL1B IL6
34 12.25 IFNG IFNGR1 IL6 TNF
35 12.17 IFNG IL1A IL1B TNF
36 12.15 CXCL8 IL10 IL1A IL1B IL6 TNF
37 12.14 BMP2 IL6 LPIN2 TNF
38 12.12 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
39
Show member pathways
12.1 IFNG IFNGR1 IL10 IL1B IL6 TNF
40 12.09 BMP2 CXCL8 IFNG IL1A IL1B IL6
41 12.08 IFNG IL10 IL6 TNF
42 12.05 CXCL8 IL1A IL1B IL6 TNF
43 12.04 CXCL8 IFNG IL10 IL1B IL6 TNF
44 12 IL1A IL1B IL6 TNF
45 11.99 CXCL8 IL1B TNF TNFSF11
46
Show member pathways
11.99 CASP1 IFNG IFNGR1 IL1B
47
Show member pathways
11.95 IFNG IL1B IL6
48 11.93 IFNG IFNGR1 IL6
49 11.93 IFNG IL10 IL1B IL6 TNF
50 11.9 IFNG IL10 IL1B TNF

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALPL BMP2 CASP1 CTSK CXCL8 IFNG
2 extracellular space GO:0005615 9.4 ALPL BMP2 CTSK CXCL8 IFNG IL10

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Name GO ID Score Top Affiliating Genes
1 dephosphorylation GO:0016311 9.97 ACP5 ALPL LPIN2 PPP3CA
2 negative regulation of gene expression GO:0010629 9.97 BMP2 IFNG PPP3CA TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 CASP1 IL1B TNF TNFSF11
4 positive regulation of protein phosphorylation GO:0001934 9.96 BMP2 IFNG IL1B TNF
5 cytokine-mediated signaling pathway GO:0019221 9.96 IL1A IL1B IL6 TNFSF11
6 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 BMP2 IFNG IL10 IL1A IL1B IL6
7 positive regulation of gene expression GO:0010628 9.95 BMP2 IFNG IL1A IL1B IL6 PPP3CA
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TNF TNFSF11
9 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IFNG IL10 IL6 TNF
10 response to lipopolysaccharide GO:0032496 9.91 ACP5 ALPL CASP1 IL10 IL1B IL6
11 positive regulation of neuron differentiation GO:0045666 9.9 BMP2 IFNG IL6
12 positive regulation of protein kinase B signaling GO:0051897 9.9 IL6 TNF TNFSF11
13 defense response to Gram-positive bacterium GO:0050830 9.89 ACP5 IL6 TNF
14 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
15 positive regulation of JNK cascade GO:0046330 9.89 IL1B TNF TNFSF11
16 cellular response to organic cyclic compound GO:0071407 9.88 ALPL BMP2 IL1B TNF
17 neutrophil chemotaxis GO:0030593 9.87 CXCL8 IFNG IL1B
18 positive regulation of T cell proliferation GO:0042102 9.87 IFNG IL1B IL6
19 humoral immune response GO:0006959 9.86 IFNG IL6 TNF
20 calcium-mediated signaling GO:0019722 9.85 CXCL8 PPP3CA TNFSF11
21 positive regulation of interleukin-6 production GO:0032755 9.83 IL1A IL1B IL6 TNF
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IFNG IL1B IL6 TNF
24 bone resorption GO:0045453 9.77 ACP5 CTSK TNFSF11
25 positive regulation of osteoclast differentiation GO:0045672 9.77 IFNG TNF TNFSF11
26 response to glucocorticoid GO:0051384 9.77 ALPL IL10 IL1RN IL6 TNF
27 defense response to protozoan GO:0042832 9.76 IFNG IL10 IL6
28 positive regulation of cytokine secretion GO:0050715 9.76 CASP1 IL10 IL1A TNF
29 inflammatory response GO:0006954 9.76 BMP2 CXCL8 IL10 IL1A IL1B IL1RN
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.74 IFNG IL10 TNF
32 negative regulation of nitric oxide biosynthetic process GO:0045019 9.73 ACP5 IL10
33 response to molecule of bacterial origin GO:0002237 9.73 CXCL8 IL10
34 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.73 IFNG IFNGR1
35 negative regulation of interleukin-12 production GO:0032695 9.73 ACP5 IL10
36 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.73 IL1A IL1B
37 positive regulation of protein import into nucleus, translocation GO:0033160 9.73 IFNG IL6
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
39 positive regulation of NFAT protein import into nucleus GO:0051533 9.72 PPP3CA TNF
40 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
41 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL10 IL1RN
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 IFNG IL1B
44 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B
45 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IFNG IL1B TNF
46 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
47 regulation of defense response to virus by host GO:0050691 9.7 IFNG IL1B
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 IFNG IL10
49 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
50 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 BMP2 CXCL8 IFNG IL10 IL1A IL1B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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