MCID: OST017
MIFTS: 59

Osteomyelitis malady

Bone diseases category

Summaries for Osteomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Osteomyelitis is the medical term for an infection in a bone. the infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. affected bone may have been predisposed to infection because of recent trauma. in children, the long bones are usually affected. in adults, the vertebrae and the pelvis are most commonly affected. bone infection can be caused by bacteria or by fungus. osteomyelitis is divided into several types depending on where an infection begins and where it occurs. types of osteomyelitis include: infections that travel through the bloodstream, infections that occur after injury or surgery, infections in people with poor circulation, and infection in the bones of the spine. last updated: 7/28/2011

MalaCards: Osteomyelitis is related to arthritis and septic arthritis. An important gene associated with Osteomyelitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Osteoblast Signaling and NF-kappa B signaling pathway. The drug ciprofloxacin and the compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia:63 Osteomyelitis (sometimes abbreviated to OM, and derived from Greek words osteon, meaning bone, myelo-... more...

Aliases & Classifications for Osteomyelitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteomyelitis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:1019
MeSH34 D010019
ICD9CM27 730.1, 730.10
ICD1025 M86, M86.9

Related Diseases for Osteomyelitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.9ALPL, LACTB, ACP5, BMP2, CTSK, TNFSF11
2septic arthritis30.8LACTB, ITGA2
3osteopetrosis30.7TNFRSF11A, TNFSF11, CTSK
4synovitis30.5TNFSF11
5osteonecrosis30.3BMP2, ALPL
6leukemia30.1CAT, BMP2, CD40LG, ACP5, LACTB, ALPL
7pneumonia30.1LACTB, FCRL6
8endocarditis30.0LACTB
9psoriasis30.0CCL27
10otitis media29.8LACTB
11osteoporosis29.8IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
12hypophosphatasia29.8ALPL
13prostatitis29.6LACTB
14giant cell tumor29.6TNFSF11, CTSK
15inflammatory bowel disease29.6ALPL
16pancreatitis29.6ALPL
17arthropathy29.6TNFSF11, BMP2, ALPL
18bone carcinoma29.6BMP2, TNFSF11, TNFRSF11A, IBSP
19lupus erythematosus29.6CD40LG
20sarcoma29.6BMP2
21secondary syphilis29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
22vascular disease29.6CAT, TNFRSF11A, TNFSF11, ITGA2
23osteoarthritis29.6IBSP, TNFRSF11A, TNFSF11, SCG2, CTSK, BMP2
24lung cancer29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ITGA2
25osteosarcoma29.6IBSP, CAT, TNFRSF11A, TNFSF11, CTSK, BMP2
26breast cancer29.6IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK, BMP2
27rheumatoid arthritis29.6IBSP, CCL27, TNFRSF11A, TNFSF11, SCG2, CTSK
28epidural abscess10.6
29discitis10.5
30periostitis10.4
31chronic recurrent multifocal osteomyelitis10.4
32sapho syndrome10.4
33chronic granulomatous disease10.4
34cervicitis10.4
35cat-scratch disease10.4
36frontal sinusitis10.4
37acne10.4
38hyperostosis10.4
39pyomyositis10.3
40tuberculosis10.2
41orbital osteomyelitis10.2
42majeed syndrome10.2
43actinomycosis10.2
44meningitis10.2
45otitis externa10.2
46diabetic foot ulcers10.2
47blastomycosis10.2
48mediastinitis10.2
49juvenile chronic recurrent multifocal osteomyelitis10.2
50adult chronic recurrent multifocal osteomyelitis10.2

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to osteomyelitis

Clinical Features for Osteomyelitis

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Drugs & Therapeutics for Osteomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Osteomyelitis

Search NIH Clinical Center for Osteomyelitis

Search CenterWatch for Osteomyelitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Osteomyelitis

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Anatomical Context for Osteomyelitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteomyelitis:

32
Bone, Bone marrow, Spinal cord, Testes, Skin, B cells, Lymph node, Brain, Liver, Prostate, T cells, Myeloid, Breast, Spleen, Lung, Temporal lobe

FMA organs/tissues related to Osteomyelitis:

14
Bone or

Animal Models for Osteomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.5ACP5
2MP:000539010.2ALPL, IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK
3MP:000539710.0TNFRSF11A, TNFSF11, CTSK, PPP3CA, ITGA2, CD40LG
4MP:000537910.0CTSK, ITGA2, CD40LG, ALPL
5MP:00053849.9TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2
6MP:00053769.8TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2

Publications for Osteomyelitis

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Sources:
50PubMed
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Articles related to Osteomyelitis:

(show top 50)    (show all 1075)
idTitleAuthorsYear
1
Streptococcal vertebral osteomyelitis: multiple faces of the same disease. (23889700)
2014
2
A proposed scoring system for assessment of severity of illness in pediatric acute hematogenous osteomyelitis using objective clinical and laboratory findings. (24352188)
2014
3
Risk factors of recurrence and life-threatening complications for patients hospitalized with chronic suppurative osteomyelitis of the jaw. (23844897)
2013
4
Osteomyelitis of the femur mimicking bone tumors: a review of 10 cases. (24148903)
2013
5
Oral Pathology Quiz #79. Case Number 4. Suppurative osteomyelitis. (23991503)
2013
6
Anti-infection tissue engineering construct treating osteomyelitis in rabbit tibia. (22861191)
2013
7
Tuberculous osteomyelitis in the ulna of a patient undergoing hemodialysis. (23291689)
2013
8
Silent chronic osteomyelitis lasting for 30 years before outburst of symptoms. (23608873)
2013
9
What is your diagnosis? Cryptococcal patellar osteomyelitis. (23445281)
2013
10
Management of chronic osteomyelitis of the tibia with life-threatening complications under negative pressure wound therapy and isolation of Helcococcus kunzii. (23855685)
2013
11
The role of active immunization therapy as preoperative treatment for chronic osteomyelitis. (23728857)
2013
12
Aspergillus osteomyelitis: Epidemiology, clinical manifestations, management, and outcome. (24378282)
2013
13
Paediatric osteomyelitis after exposure to toxic Ochrogaster lunifer moth. (23992189)
2013
14
Osteomyelitis: drug bioavailability and bone penetration are key. (22894029)
2012
15
Osteomyelitis following Bacille Calmette-Guerin vaccination. (22729129)
2012
16
The activity of paraoxonase and arylesterase in patients with osteomyelitis. (22950624)
2012
17
Diabetic foot infections with osteomyelitis: efficacy of combined surgical and medical treatment. (23050065)
2012
18
Isolated Crytococcus neoformans osteomyelitis of the proximal femur: a case report and review of literature. (22927154)
2012
19
Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis. (22792377)
2012
20
Rupture of renal mycotic aneurysm that developed during the treatment of streptococcal infective endocarditis and vertebral osteomyelitis. (22687800)
2012
21
Infantile malignant osteopetrosis: report of 2 cases with osteomyelitis of the jaws. (22828766)
2012
22
Diffuse sclerosing osteomyelitis of the mandible successfully treated with pamidronate: a long-term follow-up report. (22771405)
2012
23
Sternal Osteomyelitis and Abscess Caused by Elbowing during a Basketball Game. (22811717)
2012
24
Cryptococcal osteomyelitis of the scapula and rib in an immunocompetent patient. (22435878)
2012
25
Osteomyelitis pubis caused by Kingella kingae in an adult patient: report of the first case. (23031309)
2012
26
Sequestrectomy in primary osteomyelitis of the humerus: a new indication for posterior approach. (23160561)
2012
27
Group A streptococcal vertebral osteomyelitis presenting with acute quadriplegia. (21512790)
2011
28
Gas gangrene and osteomyelitis of the foot in a diabetic patient treated with tea tree oil. (21559069)
2011
29
Chronic recurrent multifocal osteomyelitis involving the mandible: case reports and review of the literature. (20203282)
2010
30
Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (19335222)
2009
31
Cat scratch disease with cervical vertebral osteomyelitis and spinal epidural abscess. (19654566)
2009
32
Plantar verrucous carcinoma: an unusual case of bone invasion and osteomyelitis. (19935131)
2009
33
Successful treatment of extended epidural abscess and long segment osteomyelitis: a case report and review of the literature. (17825364)
2008
34
Basidiomycetous fungal Inonotus tropicalis sacral osteomyelitis in X-linked chronic granulomatous disease. (17596815)
2007
35
RANKL and cathepsin K in diffuse sclerosing osteomyelitis of the mandible. (17032395)
2006
36
Osteomyelitis of the accessory navicular bone in the foot. A case report. (15287412)
2004
37
Vertebral osteomyelitis and epidural abscess in a patient receiving enfuvirtide. (15175933)
2004
38
Radiology quiz case. Grisel syndrome with vertebral osteomyelitis and spinal epidural abscess. (14623760)
2003
39
Neonatal cervical osteomyelitis with paraspinal abscess and Erb's palsy. A case report and brief review of the literature. (10965268)
2000
40
Discitis and vertebral osteomyelitis in children: an 18-year review. (10835072)
2000
41
Pyomyositis and osteomyelitis in a patient with radiating pain in the leg. (9249630)
1997
42
Staphylococcus aureus causing osteomyelitis binds to a nonapeptide sequence in bone sialoprotein. (9581562)
1997
43
Splenic abscess associated with osteomyelitis. (8956962)
1996
44
Mycobacterium abscessus osteomyelitis following a plantar puncture wound. (8879805)
1996
45
Radiological case of the month. Blastomycosis osteomyelitis with epidural and retropharyngeal abscess. (8522503)
1995
46
Delayed treatment of pulmonary blastomycosis causing vertebral osteomyelitis, paraspinal abscess, and spinal cord compression. (8191232)
1994
47
Periostitis ossificans versus GarrA"'s osteomyelitis. Part II: Radiologic analysis of 93 cases in the jaws. (3140161)
1988
48
Fibrodysplasia ossificans progressiva presenting as osteomyelitis-like syndrome. (3709023)
1986
49
Mycobacterium fortuitum: an unsuspected cause of synovitis and osteomyelitis. (6932838)
1980
50
Osteomyelitis caused by Mycobacterium fortuitum: report of a case. (4692987)
1973

Genetic Variations for Osteomyelitis

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Expression for genes affiliated with Osteomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for genes affiliated with Osteomyelitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Osteomyelitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL27
2procollagen4410.8ACP5, TNFSF11
3strontium ranelate4410.8IBSP, TNFSF11, CTSK
4polyethylene4410.8TNFRSF11A, TNFSF11, CTSK
5alizarin4410.8IBSP, BMP2, ALPL
6tartrate4410.8TNFSF11, CTSK, ACP5
7fibroin4410.7IBSP, BMP2
8titanium4410.7IBSP, TNFSF11, BMP2, ACP5
9zoledronic acid4410.7IBSP, TNFSF11, CTSK, BMP2
10rantes4410.7ACP5, CD40LG, SCG2
11deoxypyridinoline4410.7IBSP, CCL27, TNFSF11, ACP5
12pmma4410.7ACP5, CD40LG, TNFSF11
13methylmethacrylate4410.7IBSP, BMP2
14denosumab44 1111.7TNFRSF11A, TNFSF11
151,25 dihydroxy vitamin d34410.7ACP5, BMP2, TNFSF11, TNFRSF11A, IBSP
16raloxifene44 28 49 1113.7TNFRSF11A, TNFSF11, BMP2
17indomethacin44 59 28 1113.7BMP2
18tetracycline44 1111.7BMP2, CD40LG, ACP5, LACTB
19teriparatide44 1111.7CTSK, TNFSF11
20cycloheximide4410.6CAT, IBSP
21ibandronate44 1111.6IBSP, TNFSF11
22mevalonate4410.6BMP2, TNFSF11, IBSP
23creatinine4410.6IBSP, CCL27, TNFSF11, BMP2, ACP5
24calcitriol44 59 11 2413.6ACP5, BMP2, TNFSF11, TNFRSF11A
25tacrolimus44 49 1112.6ACP5, PPP3CA, BMP2, TNFSF11
26vitamin d4410.6IBSP, TNFSF11, BMP2, ACP5, ALPL
27laccer4410.6TNFRSF11A, TNFSF11
28ascorbic acid44 2411.6IBSP, CAT, TNFSF11, BMP2, CD40LG
29doxycycline44 1111.6TNFSF11, CD40LG, LACTB
30heparin44 28 11 2413.6IBSP, TNFSF11, BMP2, ITGA2, CD40LG, ACP5
31cyclosporin a44 28 5912.6ACP5, CD40LG, PPP3CA, BMP2, TNFSF11
32aspartate4410.6CCL27, CTSK, ITGA2, CD40LG, ACP5, ALPL
33oxygen44 2411.6IFNGR1, TNFRSF11A, TNFSF11, CTSK, BMP2, ITGA2
34vancomycin44 1111.5CD40LG, LACTB
35hydroxyapatite4410.5ALPL, IBSP, CCL27, TNFRSF11A, TNFSF11, CTSK
36vegf4410.5IBSP, TNFRSF11A, TNFSF11, SCG2, BMP2, ITGA2
37polyethylene glycol4410.5ACP5, CD40LG, BMP2
38grgdsp4410.5ITGA2, IBSP
39dexamethasone44 49 28 1113.5IBSP, CCL27, TNFRSF11A, TNFSF11, SCG2, BMP2
40nitric oxide44 11 2412.5CAT, TNFRSF11A, TNFSF11, BMP2, ITGA2, ACP5
41lipid4410.4IBSP, CCL27, CAT, TNFRSF11A, TNFSF11, BMP2
42cysteine4410.4IBSP, CAT, TNFSF11, SCG2, CTSK, BMP2
43tyrosine4410.4IBSP, IFNGR1, TNFRSF11A, TNFSF11, SCG2, CTSK
44fibrinogen4410.4IBSP, PPP3CA, ITGA2, CD40LG
45gp 1304410.4IFNGR1, TNFRSF11A, TNFSF11
46azathioprine44 49 2 1113.3ACP5, BMP2, TNFSF11
47calcium44 49 11 2413.3IBSP, CCL27, TNFRSF11A, TNFSF11, SCG2, CTSK
48rapamycin4410.3ACP5, CD40LG, BMP2, TNFSF11
49latex4410.2IBSP, TNFSF11, ITGA2
50amoxicillin44 49 1112.0LACTB, CD40LG

GO Terms for genes affiliated with Osteomyelitis

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16Gene Ontology
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Cellular components related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCRL6, CD40LG, ITGA2, TNFRSF11A
2extracellular spaceGO:0056159.7ALPL, CCL27, TNFSF11, SCG2, CTSK, BMP2

Biological processes related to Osteomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.6TNFRSF11A, TNFSF11
3bone resorptionGO:04545310.6ACP5, CTSK, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.6TNFRSF11A, TNFSF11
5ossificationGO:00150310.5TNFSF11, TNFRSF11A, IBSP
6extracellular matrix organizationGO:03019810.4IBSP, CTSK, BMP2, ITGA2
7organ morphogenesisGO:00988710.4ITGA2, BMP2, TNFSF11
8mammary gland alveolus developmentGO:06074910.4TNFSF11, TNFRSF11A
9response to lipopolysaccharideGO:03249610.3ALPL, ACP5, TNFRSF11A
10positive regulation of NF-kappaB transcription factor activityGO:05109210.2CAT, TNFRSF11A, TNFSF11
11monocyte chemotaxisGO:00254810.1TNFSF11, TNFRSF11A

Molecular functions related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.4TNFRSF11A, IFNGR1
2cytokine activityGO:0051259.9CD40LG, BMP2, SCG2, TNFSF11

Products for genes affiliated with Osteomyelitis

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  • Antibodies
  • Proteins
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Sources for Osteomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet