MCID: OST017
MIFTS: 59

Osteomyelitis malady

Bone diseases category

Summaries for Osteomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Osteomyelitis is the medical term for an infection in a bone. the infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. affected bone may have been predisposed to infection because of recent trauma. in children, the long bones are usually affected. in adults, the vertebrae and the pelvis are most commonly affected. bone infection can be caused by bacteria or by fungus. osteomyelitis is divided into several types depending on where an infection begins and where it occurs. types of osteomyelitis include: infections that travel through the bloodstream, infections that occur after injury or surgery, infections in people with poor circulation, and infection in the bones of the spine. last updated: 7/28/2011

MalaCards: Osteomyelitis is related to arthritis and septic arthritis. An important gene associated with Osteomyelitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Osteoblast Signaling and NF-kappa B signaling pathway. The drug ciprofloxacin and the compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia:63 Osteomyelitis (sometimes abbreviated to OM, and derived from Greek words osteon, meaning bone, myelo-... more...

Aliases & Classifications for Osteomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteomyelitis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:1019
MeSH34 D010019
ICD9CM27 730.1, 730.10
ICD1025 M86, M86.9

Related Diseases for Osteomyelitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.9ALPL, LACTB, ACP5, BMP2, CTSK, TNFSF11
2septic arthritis30.8LACTB, ITGA2
3osteopetrosis30.7TNFRSF11A, TNFSF11, CTSK
4synovitis30.5TNFSF11
5osteonecrosis30.3BMP2, ALPL
6leukemia30.1CAT, BMP2, CD40LG, ACP5, LACTB, ALPL
7pneumonia30.1LACTB, FCRL6
8endocarditis30.0LACTB
9psoriasis30.0CCL27
10otitis media29.8LACTB
11osteoporosis29.8IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
12hypophosphatasia29.8ALPL
13prostatitis29.6LACTB
14giant cell tumor29.6TNFSF11, CTSK
15inflammatory bowel disease29.6ALPL
16pancreatitis29.6ALPL
17arthropathy29.6TNFSF11, BMP2, ALPL
18bone carcinoma29.6BMP2, TNFSF11, TNFRSF11A, IBSP
19lupus erythematosus29.6CD40LG
20sarcoma29.6BMP2
21secondary syphilis29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
22vascular disease29.6CAT, TNFRSF11A, TNFSF11, ITGA2
23osteoarthritis29.6IBSP, TNFRSF11A, TNFSF11, SCG2, CTSK, BMP2
24lung cancer29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ITGA2
25osteosarcoma29.6IBSP, CAT, TNFRSF11A, TNFSF11, CTSK, BMP2
26breast cancer29.6IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK, BMP2
27rheumatoid arthritis29.6IBSP, CCL27, TNFRSF11A, TNFSF11, SCG2, CTSK
28epidural abscess10.6
29discitis10.5
30periostitis10.4
31chronic recurrent multifocal osteomyelitis10.4
32sapho syndrome10.4
33chronic granulomatous disease10.4
34cervicitis10.4
35cat-scratch disease10.4
36frontal sinusitis10.4
37acne10.4
38hyperostosis10.4
39pyomyositis10.3
40tuberculosis10.2
41orbital osteomyelitis10.2
42majeed syndrome10.2
43actinomycosis10.2
44meningitis10.2
45otitis externa10.2
46diabetic foot ulcers10.2
47blastomycosis10.2
48mediastinitis10.2
49juvenile chronic recurrent multifocal osteomyelitis10.2
50adult chronic recurrent multifocal osteomyelitis10.2

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to osteomyelitis

Clinical Features for Osteomyelitis

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Drugs & Therapeutics for Osteomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Osteomyelitis

Search NIH Clinical Center for Osteomyelitis

Search CenterWatch for Osteomyelitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Osteomyelitis

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Anatomical Context for Osteomyelitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteomyelitis:

32
Bone, Bone marrow, Spinal cord, Testes, Skin, B cells, Brain, Lymph node, Liver, T cells, Myeloid, Temporal lobe, Prostate, Breast, Lung, Spleen

FMA organs/tissues related to Osteomyelitis:

14
Bone or

Animal Models for Osteomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.5ACP5
2MP:000539010.2ALPL, IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK
3MP:000539710.0TNFRSF11A, TNFSF11, CTSK, PPP3CA, ITGA2, CD40LG
4MP:000537910.0CTSK, ITGA2, CD40LG, ALPL
5MP:00053849.9TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2
6MP:00053769.8TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2

Publications for Osteomyelitis

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Sources:
50PubMed
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Articles related to Osteomyelitis:

(show top 50)    (show all 1075)
idTitleAuthorsYear
1
Independent analysis of a clinical predictive algorithm to identify methicillin-resistant Staphylococcus aureus osteomyelitis in children. (23872806)
2013
2
Cutaneous disseminated sporotrichosis complicated by osteomyelitis. (22855250)
2013
3
Incremental value of SPECT/CT over planar bone scan in the evaluation of skull base osteomyelitis: A potentially fatal disease in diabetics. (24381900)
2013
4
The implications of the presence of osteomyelitis on outcomes of infected diabetic foot wounds. (23384323)
2013
5
Costal BCG osteomyelitis developing 1 year after BCG vaccination. (24134752)
2013
6
A complication following tooth extraction: chronic suppurative osteomyelitis. (24175053)
2013
7
A case of scedosporium prolificans osteomyelitis in an immunocompetent child, misdiagnosed as tubercular osteomyelitis. (23372223)
2013
8
Nocardia brasiliensis-associated femorotibial osteomyelitis. (24362018)
2013
9
Balantidium coli: an unrecognized cause of vertebral osteomyelitis and myelopathy. (23259539)
2013
10
Calcanectomy: avoiding major amputation in the presence of calcaneal osteomyelitis-A case series. (24176264)
2013
11
Primary tuberculous osteomyelitis of the mandible: A rare case report. (23946751)
2013
12
Travel-Associated Salmonella mbandaka Sacroiliac Osteomyelitis in a Healthy Adolescent. (23607008)
2013
13
Neonatal meningitis associated with osteomyelitis and epidural empyema. (23975909)
2013
14
What lies beneath: an unusual case of tuberculous osteomyelitis. (22645216)
2012
15
Performance of the probe-to-bone test in a population suspected of having osteomyelitis of the foot in diabetes. (23001730)
2012
16
General practitioner's radiology case 103. Tuberculous osteomyelitis. (23185951)
2012
17
Community-acquired methicillin-resistant Staphylococcus aureus skull base osteomyelitis with occipital condylar cerebrospinal fluid leak in an immunocompetent patient. (22447436)
2012
18
Chronic mandibular osteomyelitis with suspected underlying synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: a case report. (22427727)
2012
19
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
20
Chronic recurrent multifocal osteomyelitis: a case report. (22946018)
2011
21
Management of mandibular chronic osteomyelitis using Belfast technique. (22428525)
2011
22
Single-level/single-stage debridement and posterior instrumented fusion in the treatment of spontaneous pyogenic osteomyelitis/discitis: long-term functional outcome and health-related quality of life. (21445024)
2011
23
Mutation screening of the IL-1 receptor antagonist gene in chronic non-bacterial osteomyelitis of childhood and adolescence. (22032624)
2011
24
Acute hematogenous osteomyelitis and septic arthritis in children: clinical characteristics and outcomes study. (22043778)
2011
25
Chronic recurrent multifocal osteomyelitis: review. (21606238)
2011
26
Chronic recurrent multifocal osteomyelitis: a case report and review of literature. (22786864)
2011
27
Osteosarcoma masked by osteomyelitis and cellulitis in a dog. (20740253)
2010
28
Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy: a case report. (20955551)
2010
29
Clinical and pathological observation and treatment of chronic orbital osteomyelitis. (19776655)
2010
30
Fluctuating mixed-type hearing loss associated with synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome. (19864094)
2010
31
Limitations of magnetic resonance imaging in the diagnosis of osteomyelitis underlying diabetic foot ulcers. (19067621)
2009
32
Actinomycotic brain abscess with osteomyelitis arising from frontal sinusitis. (19367060)
2009
33
Clinical outcome in children with chronic recurrent multifocal osteomyelitis. (18621750)
2008
34
Primary mycetoma osteomyelitis of the calcaneus with active subcutaneous nodules. (17586446)
2007
35
Periostitis ossificans (GarrA"'s osteomyelitis) radiographic study of two cases. (16364095)
2006
36
Case of the month: "bugs are eating my soul"--sternal abscess, osteomyelitis, and mediastinitis complicating a closed sternal fracture. (16921099)
2006
37
Para Vertebral Abscess and Rib Osteomyelitis due to Aspergillous Fumigatus in a Patient with Chronic Granulomatous Disease. (17301351)
2003
38
Fibrous dysplasia of mandible with chronic osteomyelitis in a child: report of one case. (12632792)
2002
39
Chronic recurrent multifocal osteomyelitis with Crohn's disease exacerbation and vasculitis after granulocyte colony-stimulating factor therapy. (19078487)
2000
40
Chronic recurrent multifocal osteomyelitis showing marked improvement with corticosteroid treatment. (10813311)
2000
41
Premature epiphyseal fusion and degenerative arthritis in chronic recurrent multifocal osteomyelitis. (10741498)
2000
42
The effects of peripheral vascular disease with osteomyelitis in the diabetic foot. (10326843)
1999
43
Unexpected diagnosis of acute pyelonephritis as a cause in neonatal osteomyelitis and septic arthritis using Ga-67 citrate scintigraphy (10512116)
1999
44
African histoplasmosis: osteomyelitis of the radius. (9670760)
1998
45
Pustulosis palmoplantaris associated with chronic recurrent multifocal osteomyelitis of the mandible. (8736352)
1996
46
Neurosurgical management of thoracic and lumbar vertebral osteomyelitis and discitis in adults: a review of 43 consecutive surgically treated patients. (8727817)
1996
47
Chronic recurrent multifocal osteomyelitis. (3336727)
1988
48
Osteomyelitis of the jaws in pycnodysostosis. (3116119)
1987
49
Petrositis and osteomyelitis temporalis. (14348960)
1954
50
Chronic Osteomyelitis of the Labyrinth Capsule (Paralabyrinthitis) in Suppurative Otitis Media. (19979399)
1916

Genetic Variations for Osteomyelitis

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Expression for genes affiliated with Osteomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for genes affiliated with Osteomyelitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Osteomyelitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL27
2procollagen4410.8ACP5, TNFSF11
3strontium ranelate4410.8IBSP, CTSK, TNFSF11
4polyethylene4410.8TNFRSF11A, TNFSF11, CTSK
5alizarin4410.8IBSP, ALPL, BMP2
6tartrate4410.8ACP5, CTSK, TNFSF11
7fibroin4410.7IBSP, BMP2
8titanium4410.7ACP5, BMP2, TNFSF11, IBSP
9zoledronic acid4410.7IBSP, CTSK, TNFSF11, BMP2
10rantes4410.7ACP5, SCG2, CD40LG
11deoxypyridinoline4410.7TNFSF11, CCL27, ACP5, IBSP
12pmma4410.7TNFSF11, CD40LG, ACP5
13methylmethacrylate4410.7IBSP, BMP2
14denosumab44 1111.7TNFRSF11A, TNFSF11
151,25 dihydroxy vitamin d34410.7BMP2, IBSP, TNFRSF11A, TNFSF11, ACP5
16raloxifene44 28 49 1113.7BMP2, TNFSF11, TNFRSF11A
17indomethacin44 59 28 1113.7BMP2
18tetracycline44 1111.7LACTB, ACP5, CD40LG, BMP2
19teriparatide44 1111.7CTSK, TNFSF11
20cycloheximide4410.6CAT, IBSP
21ibandronate44 1111.6TNFSF11, IBSP
22mevalonate4410.6TNFSF11, BMP2, IBSP
23creatinine4410.6CCL27, BMP2, ACP5, IBSP, TNFSF11
24calcitriol44 59 11 2413.6TNFSF11, TNFRSF11A, BMP2, ACP5
25tacrolimus44 49 1112.6PPP3CA, ACP5, TNFSF11, BMP2
26vitamin d4410.6TNFSF11, ALPL, IBSP, ACP5, BMP2
27laccer4410.6TNFSF11, TNFRSF11A
28ascorbic acid44 2411.6CD40LG, BMP2, TNFSF11, CAT, IBSP
29doxycycline44 1111.6CD40LG, LACTB, TNFSF11
30heparin44 28 11 2413.6IBSP, TNFSF11, CD40LG, ITGA2, BMP2, ACP5
31cyclosporin a44 28 5912.6ACP5, PPP3CA, CD40LG, BMP2, TNFSF11
32aspartate4410.6CD40LG, ITGA2, ALPL, ACP5, CCL27, CTSK
33oxygen44 2411.6IFNGR1, TNFSF11, TNFRSF11A, BMP2, ACP5, ITGA2
34vancomycin44 1111.5CD40LG, LACTB
35hydroxyapatite4410.5IBSP, CCL27, TNFRSF11A, TNFSF11, CTSK, BMP2
36vegf4410.5ITGA2, CD40LG, IBSP, TNFRSF11A, TNFSF11, SCG2
37polyethylene glycol4410.5CD40LG, BMP2, ACP5
38grgdsp4410.5IBSP, ITGA2
39dexamethasone44 49 28 1113.5IBSP, SCG2, TNFRSF11A, ACP5, CD40LG, BMP2
40nitric oxide44 11 2412.5ITGA2, CAT, TNFRSF11A, ACP5, BMP2, TNFSF11
41lipid4410.4TNFRSF11A, TNFSF11, BMP2, ITGA2, ACP5, IBSP
42cysteine4410.4CAT, ACP5, IBSP, TNFSF11, SCG2, CTSK
43tyrosine4410.4ACP5, ITGA2, CTSK, SCG2, TNFRSF11A, TNFSF11
44fibrinogen4410.4IBSP, PPP3CA, CD40LG, ITGA2
45gp 1304410.4TNFSF11, TNFRSF11A, IFNGR1
46azathioprine44 49 2 1113.3BMP2, TNFSF11, ACP5
47calcium44 49 11 2413.3TNFSF11, TNFRSF11A, IBSP, CTSK, SCG2, BMP2
48rapamycin4410.3CD40LG, ACP5, BMP2, TNFSF11
49latex4410.2ITGA2, TNFSF11, IBSP
50amoxicillin44 49 1112.0LACTB, CD40LG

GO Terms for genes affiliated with Osteomyelitis

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16Gene Ontology
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Cellular components related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCRL6, CD40LG, ITGA2, TNFRSF11A
2extracellular spaceGO:0056159.7ALPL, CCL27, TNFSF11, SCG2, CTSK, BMP2

Biological processes related to Osteomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.6TNFRSF11A, TNFSF11
3bone resorptionGO:04545310.6ACP5, CTSK, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.6TNFRSF11A, TNFSF11
5ossificationGO:00150310.5TNFSF11, TNFRSF11A, IBSP
6extracellular matrix organizationGO:03019810.4IBSP, CTSK, BMP2, ITGA2
7organ morphogenesisGO:00988710.4ITGA2, BMP2, TNFSF11
8mammary gland alveolus developmentGO:06074910.4TNFSF11, TNFRSF11A
9response to lipopolysaccharideGO:03249610.3ALPL, ACP5, TNFRSF11A
10positive regulation of NF-kappaB transcription factor activityGO:05109210.2CAT, TNFRSF11A, TNFSF11
11monocyte chemotaxisGO:00254810.1TNFSF11, TNFRSF11A

Molecular functions related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.4TNFRSF11A, IFNGR1
2cytokine activityGO:0051259.9CD40LG, BMP2, SCG2, TNFSF11

Products for genes affiliated with Osteomyelitis

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  • Lysates
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Sources for Osteomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet