Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 72 49 28 51 14 69

Classifications:



Summaries for Osteomyelitis

NIH Rare Diseases : 49 Osteomyelitis is the medical term for an infection in a bone. Signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. People with the condition may also experience local swelling, redness, and warmth at the site of the infection. Although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. Osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. Risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. The goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. This may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue. Last updated: 10/19/2016

MalaCards based summary : Osteomyelitis is related to chronic recurrent multifocal osteomyelitis and toxic shock syndrome, and has symptoms including bone pain and pain in limb. An important gene associated with Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ciprofloxacin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 72 Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 chronic recurrent multifocal osteomyelitis 33.5 CASP1 FBLIM1 IL1B LPIN2
2 toxic shock syndrome 30.9 CXCL8 IFNG IL10 IL1B IL6 TNF
3 chronic granulomatous disease 30.4 IFNG IL1B TNF
4 mycobacterium tuberculosis 1 30.1 IFNG IFNGR1 IL10 TNF
5 q fever 30.1 IFNG IL10 IL1B TNF
6 melioidosis 30.1 IFNG IL10 IL6 TNF
7 interferon gamma, receptor 1, deficiency 29.9 IFNG IFNGR1
8 poliomyelitis 29.8 IFNG IL10 TNF
9 endocarditis 29.8 CXCL8 IL10 IL6 TNF
10 acute pyelonephritis 29.8 CXCL8 IL10 IL6
11 paracoccidioidomycosis 29.8 IFNG IL10 IL6 TNF
12 esophagitis 29.8 CXCL8 IL1B IL6
13 crohn's disease 29.7 IFNG IL10 IL1B IL6 TNF
14 acute transverse myelitis 29.6 CXCL8 IL10 IL6
15 pneumonia 29.6 CXCL8 IL10 IL1B IL6 TNF
16 leprosy 3 29.6 IFNG IL10 TNF
17 haemophilus influenzae 29.5 CXCL8 IL1B TNF
18 synovitis 29.5 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
19 adult-onset still's disease 29.5 IL1B IL1RN IL6 TNF
20 pyelonephritis 29.5 CXCL8 IL10 IL1B IL6 TNF
21 fasciitis 29.5 CXCL8 IL6 TNF
22 meningitis 29.5 CXCL8 IFNG IL10 IL1B IL6 TNF
23 osteonecrosis 29.5 ACP5 BMP2 TNFSF11
24 spinal cord injury 29.4 CXCL8 IL6 TNF
25 reactive arthritis 29.4 IFNG IL10 IL6 TNF
26 otitis media 29.4 CXCL8 IL10 IL1B IL6 TNF
27 extrapulmonary tuberculosis 29.3 IFNG IL10 IL1A IL1B
28 common variable immunodeficiency 29.3 IFNG IL10 IL6 TNF
29 transverse myelitis 29.3 CXCL8 IL10 IL6 TNF
30 prostatitis 29.3 CXCL8 IL10 IL1B IL6 TNF
31 appendicitis 29.3 CXCL8 IL10 IL1B IL6 TNF
32 hemophagocytic lymphohistiocytosis 29.2 CXCL8 IFNG IL10 TNF
33 familial mediterranean fever 29.2 CASP1 IL1B IL1RN TNF
34 acquired immunodeficiency syndrome 29.2 IFNG IL10 IL1B IL6 TNF
35 ulcerative colitis 29.1 CXCL8 IFNG IL10 IL1B IL6 TNF
36 colitis 29.1 CXCL8 IFNG IL10 IL1B IL6 TNF
37 lymphadenitis 29.1 CXCL8 IFNG IFNGR1 IL10 IL1B TNF
38 bacterial meningitis 29.0 CXCL8 IL10 IL1B IL6 TNF
39 joint disorders 29.0 IL1B IL1RN IL6 TNF TNFSF11
40 wegener granulomatosis 29.0 CXCL8 IFNG IL10 IL6 TNF
41 arthritis 28.9 CXCL8 IFNG IL10 IL1A IL1B IL1RN
42 autoimmune disease 28.9 IFNG IL10 IL1B IL1RN IL6 TNF
43 gingivitis 28.9 CXCL8 IL1A IL1B IL6 TNF
44 brucellosis 28.8 CXCL8 IFNG IL10 IL1RN IL6 TNF
45 osteoarthritis 28.8 CXCL8 IL1B IL6 TNF TNFSF11
46 peritonitis 28.8 CXCL8 IFNG IL10 IL1B IL6 TNF
47 psoriasis 28.6 CXCL8 IFNG IL10 IL1A IL1B IL6
48 typhoid fever 28.6 CASP1 IFNG IFNGR1 IL1B IL6 TNF
49 bone inflammation disease 27.7 ACP5 CXCL8 IFNG IL10 IL1A IL1B
50 periodontitis 27.4 CTSK CXCL8 IFNG IL10 IL1A IL1B

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


bone pain, pain in limb

MGI Mouse Phenotypes related to Osteomyelitis:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
2 homeostasis/metabolism MP:0005376 10.31 TNFSF11 BMP2 CASP1 CTSK IFNG IFNGR1
3 immune system MP:0005387 10.28 BMP2 CASP1 CTSK FBLIM1 IFNG IFNGR1
4 cardiovascular system MP:0005385 10.26 BMP2 CASP1 IFNG IFNGR1 IL10 IL1A
5 growth/size/body region MP:0005378 10.22 BMP2 CTSK IFNG IL10 IL1B IL1RN
6 mortality/aging MP:0010768 10.13 BMP2 CASP1 IFNG IFNGR1 IL10 IL1B
7 digestive/alimentary MP:0005381 10.1 IFNG IFNGR1 IL10 IL6 TNF BMP2
8 integument MP:0010771 10.07 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
9 craniofacial MP:0005382 10.05 BMP2 CTSK IFNG IL10 IL1B TNF
10 nervous system MP:0003631 9.93 IFNG IFNGR1 IL10 IL1B IL6 LPIN2
11 neoplasm MP:0002006 9.91 CASP1 IFNG IFNGR1 IL10 IL1A IL1B
12 reproductive system MP:0005389 9.7 IFNG IFNGR1 IL10 IL1RN IL6 LPIN2
13 skeleton MP:0005390 9.36 IL1B IL1RN IL6 TNF TNFSF11 BMP2

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Early Phase 1 85721-33-1 2764
2
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 738-70-5 5578
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1404-90-6 14969 441141
6
Cefepime Approved, Investigational Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
7
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 5742673 456256
8
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
9
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
10
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
11
Fusidic Acid Approved, Investigational Phase 4,Phase 2,Phase 3 6990-06-3 3000226
12
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
13
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
14
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
15
Rifampin Approved Phase 4,Early Phase 1 13292-46-1 5381226 5458213
16
Dalbavancin Approved, Investigational Phase 4,Phase 3,Phase 2 171500-79-1, 91097-81-3 122186
17
Nafcillin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 147-52-4, 985-16-0 8982
18
Teicoplanin Approved, Investigational Phase 4,Phase 3,Phase 2 61036-62-2
19
Cefazolin Approved Phase 4,Phase 3 25953-19-9 33255 656510
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 59-30-3 6037
21
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 58-05-9 143 6006
22
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
23 Gentamicins Phase 4,Early Phase 1
24 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
28 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
29 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
30 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Early Phase 1
31 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
32 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
33 Renal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 Topoisomerase Inhibitors Phase 4,Phase 2,Early Phase 1
35 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Phase 2,Early Phase 1
36 Vitamin B Complex Phase 4,Phase 3,Phase 2,Early Phase 1
37 methicillin Phase 4,Phase 3,Early Phase 1
38 Antitubercular Agents Phase 4,Phase 3,Phase 2,Early Phase 1
39 Cytochrome P-450 CYP3A Inducers Phase 4,Early Phase 1
40 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
41 Dermatologic Agents Phase 4
42 Micronutrients Phase 4
43 Photosensitizing Agents Phase 4
44 Trace Elements Phase 4
45 Vitamins Phase 4
46 Cephalosporins Phase 4,Phase 1,Phase 2
47 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
48 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
49 Vitamin B2 Nutraceutical Phase 4
50
Amoxicillin Approved, Vet_approved Phase 3,Early Phase 1 26787-78-0 33613 2171

Interventional clinical trials:

(show top 50) (show all 82)

# Name Status NCT ID Phase Drugs
1 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
2 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
3 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
4 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
5 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
6 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
7 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
8 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
9 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
10 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
11 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
12 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
13 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
14 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
15 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
16 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Recruiting NCT03174366 Phase 3 Denosumab
17 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
18 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
19 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
20 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
21 Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Subjects With Osteomyelitis Completed NCT02685033 Phase 2 Dalbavancin;Comparator
22 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
23 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis Recruiting NCT02168816 Phase 2 piperacillin/tazobactam, cefepime, metronidazole, aztreonam,vancomycin, daptomycin, linezolid ,meropenem;sulfamethoxazole/trimethoprim , clindamycin ,linezolid, moxifloxacin ,ciprofloxacin ,metronidazole
24 Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Recruiting NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
25 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Recruiting NCT02594878 Phase 2 Pamidronatdinatrium
26 Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites Recruiting NCT02436876 Phase 2 MBN-101
27 Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration Recruiting NCT02842619 Phase 1, Phase 2
28 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
29 Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Terminated NCT03091439 Phase 2 Dalbavancin;Standard-of-Care
30 [124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection Terminated NCT01764919 Phase 2
31 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
32 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Unknown status NCT02165579
33 Detection of Osteomyelitis Using High Resolution Ultrasound Unknown status NCT02198755
34 Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903 Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
35 Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus (MRSA) Osteomyelitis (VOTSMO) Unknown status NCT00324922 trimethoprim-sulfamethoxazole;vancomycin
36 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979
37 Characterizing and Diagnosis’s of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients Unknown status NCT00157222
38 Clinical Evaluation of Daptomycin Bone Penetration Unknown status NCT01306825
39 Computed Tomography (CT) Score and Histopathology of the Middle Turbinate in Chronic Rhinosinusitis Unknown status NCT00899561
40 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT) Completed NCT02308774
41 Characterization and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
42 Risk Factors for Three Critical Stages of the Diabetic Foot Infections Completed NCT02736253
43 Pressure Ulcer-associated Osteomyelitis: Evaluation of a Two-stage Surgical Strategy With Prolonged Antimicrobial Therapy Completed NCT03010293
44 Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ Completed NCT01670422
45 Drug Delivery Devices for Osteomyelitis Completed NCT02968693 Vancomycin
46 Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections Completed NCT02311452
47 A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients Completed NCT03380403
48 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
49 Bisphosphonate-Associated Jaw Osteonecrosis and PET Imaging Completed NCT00592982
50 Biofilm Formation in Staphylococcus Epidermidis Associated Implant Infections Completed NCT02640937

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

# Genetic test Affiliating Genes
1 Osteomyelitis 28

Anatomical Context for Osteomyelitis

The Foundational Model of Anatomy Ontology organs/tissues related to Osteomyelitis:

18
Bone Or

MalaCards organs/tissues related to Osteomyelitis:

38
Bone, Testes, Bone Marrow, Spinal Cord, Skin, Lung, Neutrophil

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 1414)
# Title Authors Year
1
Chronic non-suppurative mandibular osteomyelitis with proliferative periostitis: A review. ( 29399678 )
2018
2
Mandibular Involvement in Recurrent Multifocal Osteomyelitis Associated with SAPHO Syndrome. ( 29387665 )
2018
3
Tuberculous osteomyelitis of the wrist presenting as a monoarthritis syndrome. ( 29437679 )
2018
4
Advanced Imaging Techniques in Skull Base Osteomyelitis Due to Malignant Otitis Externa. ( 29416952 )
2018
5
<i>Propionibacterium acnes</i> and<i>Staphylococcus epidermidis</i>olecranon bursitis/osteomyelitis: a case involving surgical and antibiotic treatment. ( 29440139 )
2018
6
Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity. ( 29412958 )
2018
7
Campylobacter jejuni vertebral osteomyelitis or tuberculosis: persisting diagnostic ambiguity - Authors' reply. ( 29412960 )
2018
8
Vancomycin incorporated chitosan/gelatin coatings coupled with TiO<sub>2</sub>-SrHAP surface modified cp-titanium for osteomyelitis treatment. ( 29395341 )
2018
9
Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. ( 29124297 )
2018
10
Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions. ( 29444953 )
2018
11
Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis. ( 29405452 )
2018
12
Actinomycotic osteomyelitis. ( 29451191 )
2018
13
Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity. ( 29425755 )
2018
14
Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis. ( 29434141 )
2018
15
Escherichia coli isolates from femoral bone marrow of broilers exhibit diverse pheno- and genotypic characteristics that do not correlate with macroscopic lesions of bacterial chondronecrosis with osteomyelitis (BCO). ( 29451003 )
2018
16
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
17
Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder. ( 29425711 )
2018
18
Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products. ( 29391581 )
2018
19
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report. ( 29443819 )
2018
20
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
21
Biologic treatment for chronic recurrent multifocal osteomyelitis: report of four cases and review of the literature. ( 29127574 )
2018
22
Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis. ( 29403199 )
2018
23
Chronic non-suppurative mandibular osteomyelitis with proliferative periostitis: A review. ( 29435520 )
2018
24
Beyond ulcers and osteomyelitis: imaging of less common musculoskeletal complications in diabetes mellitus. ( 29419313 )
2018
25
Chronic Recurrent Multifocal Osteomyelitis: A Case Report with Atypical Presentation. ( 28630846 )
2017
26
Epidemiological, bacteriological and therapeutic aspects of chronic osteomyelitis in a sub-Saharan environment. ( 28947406 )
2017
27
Chronic recurrent multifocal osteomyelitis: a case report. ( 29062831 )
2017
28
Osteomyelitis of the foot: non-surgical management, SPECT/CT scanning and minimising the duration of antibiotic use. ( 28936764 )
2017
29
Rare case of disseminated rhinosporidiosis with chronic osteomyelitis of the calcaneum treated by a simple technique of negative pressure wound therapy. ( 29038194 )
2017
30
A novel case of Raoultella planticola osteomyelitis and epidural abscess. ( 28705846 )
2017
31
Clostridium sphenoides Chronic Osteomyelitis Diagnosed Via Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, Conflicting With 16S rRNA Sequencing but Confirmed by Whole Genome Sequencing. ( 28051992 )
2017
32
Staphylococcus lugdunensis: An Underreported Pathogen in Osteomyelitis. ( 28073654 )
2017
33
Adult-onset Chronic Recurrent Multifocal Osteomyelitis with High Intensity of Muscles Detected by Magnetic Resonance Imaging, Successfully Controlled with Tocilizumab. ( 28794369 )
2017
34
Sternoclavicular joint osteomyelitis extending to lung abscess complicated by Staphylococcal infective endocarditis. ( 28660126 )
2017
35
A link between osteomyelitis and IL1RN and IL1B polymorphisms-a study in patients from Northeast Brazil. ( 28682145 )
2017
36
Chronic Osteomyelitis of the Distal Femur Treated with Resection and Delayed Endoprosthetic Reconstruction: A Report of Three Cases. ( 28894615 )
2017
37
Primary fusobacterium osteomyelitis and pyomyositis of the thigh in an immunocompetent young adult. ( 28876557 )
2017
38
Osteomyelitis and arthritis caused by Mycobacterium intracellulare: an underestimated diagnosis. ( 28911365 )
2017
39
Salmonella pyomyositis with concurrent sacroiliac osteomyelitis presenting as piriformis syndrome: A rare case. ( 27779154 )
2017
40
Chronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy. ( 28656169 )
2017
41
Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats. ( 28064219 )
2017
42
Osteomyelitis due to Mycobacterium kansasii in a patient with sarcoidosis. ( 28529884 )
2017
43
Erratum: Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits [Corrigendum]. ( 28894362 )
2017
44
Blood perfusion in osteomyelitis studied with [(15)O]water PET in a juvenile porcine model. ( 28091979 )
2017
45
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
46
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
47
Pathological fracture of the femoral neck following septic coxitis and chronic osteomyelitis: a potential complication of Lemierre's syndrome. ( 28536211 )
2017
48
Chronic recurrent multifocal osteomyelitis exhibiting predominance of periosteal reaction. ( 28614530 )
2017
49
An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children. ( 28401420 )
2017
50
Osteomyelitis Risk in Patients With Transfemoral Amputations Treated With Osseointegration Prostheses. ( 28940152 )
2017

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CASP1 CTSK CXCL8 IFNG IFNGR1 IL10
2
Show member pathways
13.88 BMP2 CXCL8 FBLIM1 IL10 IL1A IL1B
3
Show member pathways
13.75 BMP2 CASP1 CXCL8 IFNG IFNGR1 IL10
4
Show member pathways
13.61 BMP2 CXCL8 IFNG IFNGR1 IL10 IL1A
5
Show member pathways
13.48 BMP2 CXCL8 IL10 IL1A IL1B IL6
6
Show member pathways
13.47 CASP1 CXCL8 IFNG IFNGR1 IL10 IL1A
7
Show member pathways
13.4 BMP2 CASP1 CXCL8 IL10 IL1A IL1B
8
Show member pathways
13.1 CASP1 CXCL8 IL1A IL1B IL1RN IL6
9
Show member pathways
12.97 CXCL8 IFNG IL10 IL1A IL1B IL6
10
Show member pathways
12.93 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
11 12.89 BMP2 CXCL8 IFNG IFNGR1 IL6
12 12.82 CASP1 IL1A IL1B PPP3CA TNF
13
Show member pathways
12.82 CASP1 CXCL8 IFNG IL1B IL6 TNF
14
Show member pathways
12.77 BMP2 IL1A IL1B IL6 TNF
15
Show member pathways
12.73 IFNG IFNGR1 IL1A IL1B TNF
16
Show member pathways
12.72 CASP1 IL1A IL1B PPP3CA TNF TNFSF11
17
Show member pathways
12.72 IFNG IFNGR1 IL10 IL1A IL1B IL6
18
Show member pathways
12.71 IFNG IFNGR1 IL10 PPP3CA TNF
19 12.71 IFNG IL10 IL1B IL1RN PPP3CA TNF
20
Show member pathways
12.67 IFNG IL10 IL1B IL6 TNF
21
Show member pathways
12.65 CXCL8 IFNGR1 IL6 PPP3CA TNF
22
Show member pathways
12.65 CTSK CXCL8 IFNG IFNGR1 IL10 IL1B
23
Show member pathways
12.58 IFNG IL10 IL1A IL1B IL6 PPP3CA
24
Show member pathways
12.49 ACP5 CTSK IL10 PPP3CA TNFSF11
25
Show member pathways
12.43 IFNG IFNGR1 IL10 IL6
26
Show member pathways
12.43 CXCL8 IFNG IL1B IL6 TNF
27
Show member pathways
12.41 IFNG IFNGR1 IL10 IL1A IL1B TNF
28
Show member pathways
12.39 IFNG IL1B IL6 TNF
29
Show member pathways
12.39 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
30
Show member pathways
12.37 CASP1 IL1A IL1B IL1RN
31
Show member pathways
12.37 CASP1 IFNG IFNGR1 IL1A IL1B TNF
32
Show member pathways
12.34 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
33
Show member pathways
12.33 CXCL8 IL1A IL6 TNF
34 12.29 CXCL8 IL10 IL1A IL1B IL1RN IL6
35 12.26 IFNG IFNGR1 IL6 TNF
36
Show member pathways
12.26 CXCL8 IFNG IL10 IL1A IL1B IL6
37 12.26 IFNG IFNGR1 IL10 IL1A IL1B IL6
38 12.24 CXCL8 IL1A IL6 PPP3CA
39 12.17 IFNG IL1A IL1B TNF
40 12.15 BMP2 IL6 LPIN2 TNF
41 12.15 CXCL8 IL10 IL1A IL1B IL6 TNF
42 12.12 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
43 12.11 BMP2 CXCL8 IFNG IL1A IL1B IL6
44
Show member pathways
12.09 IFNG IFNGR1 IL10 IL1B IL6 TNF
45 12.08 IFNG IL10 IL6 TNF
46 12.06 CXCL8 IL1A IL1B IL6 TNF
47 12.05 CXCL8 IFNG IL10 IL1B IL6 TNF
48 12 IL1A IL1B IL6 TNF
49 11.99 CXCL8 IL1B TNF TNFSF11
50
Show member pathways
11.99 CASP1 IFNG IFNGR1 IL1B

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BMP2 CASP1 CTSK CXCL8 IFNG IL10
2 extracellular space GO:0005615 9.36 BMP2 CTSK CXCL8 IFNG IL10 IL1A

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.98 BMP2 IFNG PPP3CA TNF
2 positive regulation of gene expression GO:0010628 9.98 BMP2 IFNG IL1A IL1B IL6 PPP3CA
3 response to lipopolysaccharide GO:0032496 9.96 ACP5 CASP1 IL10 IL1B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.94 CASP1 IL1B TNF TNFSF11
5 positive regulation of protein phosphorylation GO:0001934 9.93 BMP2 IFNG IL1B TNF
6 cytokine-mediated signaling pathway GO:0019221 9.92 IL1A IL1B IL6 TNFSF11
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TNF TNFSF11
8 defense response to Gram-positive bacterium GO:0050830 9.88 ACP5 IL6 TNF
9 cellular response to lipopolysaccharide GO:0071222 9.88 CASP1 CXCL8 IL10 IL6 TNF
10 cellular response to organic cyclic compound GO:0071407 9.87 BMP2 IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.86 IL1B TNF TNFSF11
12 regulation of insulin secretion GO:0050796 9.86 IFNG IL1B TNF
13 inflammatory response GO:0006954 9.86 BMP2 CXCL8 IL10 IL1A IL1B IL1RN
14 humoral immune response GO:0006959 9.84 IFNG IL6 TNF
15 calcium-mediated signaling GO:0019722 9.83 CXCL8 PPP3CA TNFSF11
16 response to glucocorticoid GO:0051384 9.83 IL10 IL1RN IL6 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.8 IL1A IL1B IL6 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IFNG IL1B TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.77 IL1A IL1B TNF
20 bone resorption GO:0045453 9.74 ACP5 CTSK TNFSF11
21 positive regulation of osteoclast differentiation GO:0045672 9.72 IFNG TNF TNFSF11
22 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG IFNGR1
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF
24 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 IL10
25 negative regulation of interleukin-12 production GO:0032695 9.7 ACP5 IL10
26 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
27 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
28 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.69 IL10 IL1RN
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL10 IL1B TNF
30 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
32 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
33 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
34 ectopic germ cell programmed cell death GO:0035234 9.67 IL1A IL1B
35 positive regulation of cytokine secretion GO:0050715 9.67 CASP1 IL10 IL1A TNF
36 positive regulation of NFAT protein import into nucleus GO:0051533 9.65 PPP3CA TNF
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
38 interleukin-1 beta production GO:0032611 9.64 CASP1 IL1B
39 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
40 positive regulation of DNA binding transcription factor activity GO:0051091 9.63 IL10 IL1B IL6 PPP3CA TNF TNFSF11
41 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
42 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 IL1RN IL6
43 immune response GO:0006955 9.61 CXCL8 IFNG IL10 IL1A IL1B IL1RN
44 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 IFNG TNF
46 fever generation GO:0001660 9.58 IL1A IL1B IL1RN
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.5 IFNG IL1B TNF
48 regulation of receptor activity GO:0010469 9.32 BMP2 CXCL8 IFNG IL10 IL1A IL1B
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 BMP2 IL10 IL1A IL1B IL6 LPIN2
50 negative regulation of cell proliferation GO:0008285 10.03 BMP2 CXCL8 IL10 IL1A IL1B IL6

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 BMP2 CXCL8 IFNG IL10 IL1A IL1B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 protein binding GO:0005515 10.06 BMP2 CASP1 CTSK CXCL8 FBLIM1 IFNG

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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