MCID: OST017
MIFTS: 58

Osteomyelitis malady

Rare diseases, Bone diseases categories

Summaries for Osteomyelitis

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Osteomyelitis is the medical term for an infection in a bone. the infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. affected bone may have been predisposed to infection because of recent trauma. in children, the long bones are usually affected. in adults, the vertebrae and the pelvis are most commonly affected. bone infection can be caused by bacteria or by fungus. osteomyelitis is divided into several types depending on where an infection begins and where it occurs. types of osteomyelitis include: infections that travel through the bloodstream, infections that occur after injury or surgery, infections in people with poor circulation, and infection in the bones of the spine. last updated: 7/28/2011

MalaCards: Osteomyelitis is related to osteopetrosis and arthritis. An important gene associated with Osteomyelitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. The drug ciprofloxacin and the compounds strontium ranelate and toluidine have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and bone marrow, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Disease Ontology:9 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia:66 Osteomyelitis (sometimes abbreviated to OM, and derived from Greek words osteon, meaning bone, myelo-... more...

Aliases & Classifications for Osteomyelitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

osteomyelitis 9 44 11 46 63


External Ids:

Disease Ontology9 DOID:1019
MeSH36 D010019
ICD9CM28 730.1, 730.10
ICD1026 M86, M86.9

Related Diseases for Osteomyelitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 305)
idRelated DiseaseScoreTop Affiliating Genes
1osteopetrosis30.8CTSK, TNFRSF11A
2arthritis30.7CTSK, ALPL, BMP2, ACP5, TNFRSF11A
3osteonecrosis30.4ALPL, BMP2
4fibrous dysplasia30.0IBSP, ALPL
5giant cell tumor29.7TNFRSF11A, CTSK
6arthropathy29.7BMP2, ALPL
7osteoporosis29.7IBSP, TNFRSF11A, ACP5, BMP2, ALPL, CTSK
8lung cancer29.6IBSP, TNFRSF11A, BMP2, CTSK
9osteoarthritis29.6IBSP, TNFRSF11A, ACP5, BMP2, CTSK
10rheumatoid arthritis29.6IBSP, TNFRSF11A, ACP5, BMP2, CTSK
11secondary syphilis29.4IBSP, TNFRSF11A, ACP5, BMP2, ALPL, CTSK
12osteosarcoma29.4IBSP, TNFRSF11A, ACP5, BMP2, ALPL, CTSK
13breast cancer29.4IBSP, TNFRSF11A, IFNGR1, ACP5, BMP2, ALPL
14chronic recurrent multifocal osteomyelitis10.9
15epidural abscess10.6
16discitis10.6
17septic arthritis10.6
18periostitis10.5
19sapho syndrome10.5
20chronic granulomatous disease10.4
21cervicitis10.4
22sinusitis10.4
23cat-scratch disease10.4
24acne10.4
25frontal sinusitis10.4
26hyperostosis10.4
27synovitis10.4
28mycobacterium fortuitum10.3
29pyomyositis10.3
30tuberculosis10.3
31majeed syndrome10.3
32actinomycosis10.2
33meningitis10.2
34otitis externa10.2
35diabetic foot ulcers10.2
36blastomycosis10.2
37mediastinitis10.2
38mycobacterium kansasii10.2
39melioidosis10.2
40malignant otitis externa10.2
41pycnodysostosis10.2
42neuropathy10.2
43mycobacterium chelonae10.2
44mycobacterium marinum10.2
45aneurysm10.2
46crohn's disease10.1
47gaucher's disease10.1
48orbital osteomyelitis10.1
49cellulitis10.1
50leukemia10.1

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to osteomyelitis

Symptoms for Osteomyelitis

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Drugs & Therapeutics for Osteomyelitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Osteomyelitis

Search NIH Clinical Center for Osteomyelitis

Search CenterWatch for Osteomyelitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Osteomyelitis

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Anatomical Context for Osteomyelitis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Osteomyelitis:

34
Bone, Bone marrow, Spinal cord, Testes, Skin, Lymph node, Brain, B cells, Liver, Spleen, Prostate, T cells, Myeloid, Breast, Lung, Temporal lobe

FMA organs/tissues related to Osteomyelitis:

15
Bone or

Animal Models for Osteomyelitis or affiliated genes

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38MGI
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Publications for Osteomyelitis

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53PubMed
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Articles related to Osteomyelitis:

(show top 50)    (show all 1064)
idTitleAuthorsYear
1
The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis. (24308337)
2014
2
Influence of osteomyelitis location in the foot of diabetic patients with transtibial amputation. (23413061)
2013
3
Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. II. Antibacterial and osteoblastic response. (23115128)
2013
4
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis. (22961119)
2013
5
Concomitant osteomyelitis and avascular necrosis of the talus treated with talectomy and tibiocalcaneal arthrodesis. (23465813)
2013
6
In Vitro Analysis of Nanoparticulate Hydroxyapatite/Chitosan Composites as Potential Drug Delivery Platforms for the Sustained Release of Antibiotics in the Treatment of Osteomyelitis. (24382825)
2013
7
Quantitative simultaneous 111Ina8999mTc SPECT-CT of osteomyelitis. (23927346)
2013
8
New treatment option for sclerosing osteomyelitis of GarrAc. (23812085)
2013
9
Clostridium difficile vertebral osteomyelitis. (23594589)
2013
10
Post-tsunami primary Scedosporium apiospermum osteomyelitis of the knee in an immunocompetent patient. (23523561)
2013
11
An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis. (23899021)
2013
12
Bacteria detected after instrumentation surgery for pyogenic vertebral osteomyelitis in a canine model. (24121752)
2013
13
Diagnosing diabetic foot osteomyelitis in patients without signs of soft tissue infection by coupling hybrid 67Ga SPECT/CT with bedside percutaneous bone puncture. (23514729)
2013
14
Chronic osteomyelitis of the pelvis. (23926730)
2013
15
Mycobacterium szulgai Chronic Multifocal Osteomyelitis in an Adolescent with Inherited STAT1 Deficiency. (24061272)
2013
16
Independent analysis of a clinical predictive algorithm to identify methicillin-resistant Staphylococcus aureus osteomyelitis in children. (23872806)
2013
17
In vitro/in vivo comparison of cefuroxime release from poly(I/-caprolactone)-calcium sulfate implants for osteomyelitis treatment. (23586705)
2013
18
Deep vein thrombosis and septic pulmonary emboli with MRSA osteomyelitis in a pediatric patient. (22940890)
2012
19
Pediatric chronic nonbacterial osteomyelitis. (23071213)
2012
20
Low-grade osteomyelitis of the fifth metatarsal with possible concomitant Freiberg's disease of the metatarsal head. (22981237)
2012
21
Fulminant spread of a femur anaerobic osteomyelitis to abdomen in a 17-year-old boy. (22482093)
2012
22
Infantile osteomyelitis secondary to malignant osteopetrosis. (23449725)
2012
23
What lies beneath: an unusual case of tuberculous osteomyelitis. (22645216)
2012
24
Osteomyelitis and pyoarthritis resulting from local paracoccidioidomycosis in an immunocompetent patient: a case report. (23043817)
2012
25
Osteomyelitis and pyomyositis due to Pseudomonas aeruginosa in a child with sickle I^a8^-thalassemia. (21792030)
2011
26
Normophosphatemic type tumoral calcinosis associated with chronic recurrent multifocal osteomyelitis: a case report. (21610312)
2011
27
Tibial chronic osteomyelitis due to Propionibacterium acnes in a patient with sickle cell anemia. (19913448)
2010
28
Vertebral osteomyelitis and discitis with epidural abscess: an unusual finding ten weeks post open abdominal aortic aneurysm repair. (20336910)
2010
29
Chronic subdural empyema and cranial vault osteomyelitis due to Salmonella paratyphi A. (20061768)
2010
30
Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery. (19101840)
2009
31
Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. (18346517)
2008
32
Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. (17912555)
2008
33
Chronic recurrent multifocal osteomyelitis. (18061969)
2007
34
Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs. (16842278)
2006
35
Trimethoprim-sulfamethoxazole in the treatment of Stenotrophomonas maltophilia osteomyelitis. (15844086)
2005
36
Neonatal cervical osteomyelitis with paraspinal abscess and Erb's palsy. A case report and brief review of the literature. (10965268)
2000
37
Discitis and vertebral osteomyelitis in children: an 18-year review. (10835072)
2000
38
Chronic recurrent multifocal osteomyelitis--report of eight patients. (9880747)
1998
39
Pyomyositis and osteomyelitis in a patient with radiating pain in the leg. (9249630)
1997
40
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
41
Case report: chronic recurrent multifocal osteomyelitis with magnetic resonance imaging. (8124893)
1994
42
Chronic recurrent multifocal osteomyelitis: report of a case. (1554846)
1992
43
Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. (2319176)
1990
44
Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. (2643605)
1989
45
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. (2809904)
1989
46
Postcraniotomy mycetoma of the scalp and osteomyelitis due to Pseudallescheria boydii. (3655408)
1987
47
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
48
Pustulosis palmoplantaris and its relation to chronic recurrent multifocal osteomyelitis. (478042)
1979
49
Acute spreading osteomyelitis of the skull complicating frontal sinusitis. (833490)
1977
50
Chronic osteomyelitis of the frontal bone, secondary to frontal sinusitis. (20987381)
1945

Variations for Osteomyelitis

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Expression for genes affiliated with Osteomyelitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for genes affiliated with Osteomyelitis

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51PathCards, 56Reactome, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Osteomyelitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2CTSK, BMP2, IBSP
2
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.0CTSK, ACP5, TNFRSF11A
39.0TNFRSF11A, ACP5, CTSK
49.0CTSK, ACP5, TNFRSF11A
58.6CTSK, ACP5, IFNGR1, TNFRSF11A

Compounds for genes affiliated with Osteomyelitis

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Osteomyelitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1strontium ranelate4610.2CTSK, IBSP
2toluidine4610.0IBSP, ACP5
3tartrate4610.0ACP5, CTSK
4fibroin4610.0BMP2, IBSP
5methylmethacrylate4610.0BMP2, IBSP
6deoxypyridinoline4610.0ACP5, IBSP
7chitosan4610.0BMP2, IBSP
8hydroxyproline46 25 1211.9IBSP, ACP5
9polyethylene469.9CTSK, TNFRSF11A
10mevalonate469.8IBSP, BMP2
11zoledronic acid469.7CTSK, BMP2, IBSP
12tetracycline46 1210.6BMP2, ACP5
13glycosaminoglycan469.6BMP2, IBSP
14raloxifene46 52 30 1212.6BMP2, TNFRSF11A
15titanium469.6IBSP, ACP5, BMP2
164-Nitrophenol259.6ALPL, ACP5
17procollagen469.6IBSP, ACP5, BMP2
18Propyl alcohol259.5ACP5, ALPL
19Isopropyl alcohol259.5ACP5, ALPL
20Isobutanol259.5ACP5, ALPL
211-Pentanol259.5ACP5, ALPL
221-Hexanol259.5ACP5, ALPL
23polyethylene glycol469.5ACP5, BMP2
241-Butanol259.5ALPL, ACP5
25creatinine469.4BMP2, ACP5, IBSP
26gp 130469.3IFNGR1, TNFRSF11A
27heparin46 30 25 1212.3IBSP, ACP5, BMP2
28calcitriol46 62 25 1212.2TNFRSF11A, ACP5, BMP2
29alizarin469.2IBSP, BMP2, ALPL
30azathioprine46 3 52 1212.2BMP2, ACP5
31aspartate469.0CTSK, ALPL, ACP5
321,25 dihydroxy vitamin d3469.0BMP2, ACP5, TNFRSF11A, IBSP
33pge2468.9IBSP, TNFRSF11A, ACP5, BMP2
34dexamethasone46 52 30 1211.9BMP2, ACP5, TNFRSF11A, IBSP
35estrogen468.8IBSP, TNFRSF11A, ACP5, BMP2
36lipid468.8IBSP, TNFRSF11A, ACP5, BMP2
37vitamin d468.7ALPL, BMP2, ACP5, IBSP
38serine468.7CTSK, BMP2, TNFRSF11A, IBSP
39oxygen46 259.5TNFRSF11A, IFNGR1, ACP5, BMP2, CTSK
40cysteine468.4CTSK, ALPL, BMP2, ACP5, IBSP
41tyrosine468.2IBSP, TNFRSF11A, IFNGR1, ACP5, BMP2, CTSK
42hydroxyapatite467.8CTSK, ALPL, BMP2, ACP5, TNFRSF11A, IBSP
43calcium46 52 25 1210.7IBSP, TNFRSF11A, ACP5, BMP2, ALPL, CTSK

GO Terms for genes affiliated with Osteomyelitis

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17Gene Ontology
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Biological processes related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bone resorptionGO:0454539.7CTSK, ACP5
2ossificationGO:0015039.5TNFRSF11A, IBSP
3extracellular matrix organizationGO:0301989.1IBSP, BMP2, CTSK
4cellular response to organic cyclic compoundGO:0714079.1ALPL, BMP2
5response to cytokineGO:0340979.1ACP5, TNFRSF11A
6response to lipopolysaccharideGO:0324968.7ALPL, ACP5, TNFRSF11A

Molecular functions related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:0199559.4IFNGR1, TNFRSF11A

Products for genes affiliated with Osteomyelitis

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Sources for Osteomyelitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet