MCID: OST017
MIFTS: 59

Osteomyelitis malady

Bone diseases category

Summaries for Osteomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Osteomyelitis is the medical term for an infection in a bone. the infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. affected bone may have been predisposed to infection because of recent trauma. in children, the long bones are usually affected. in adults, the vertebrae and the pelvis are most commonly affected. bone infection can be caused by bacteria or by fungus. osteomyelitis is divided into several types depending on where an infection begins and where it occurs. types of osteomyelitis include: infections that travel through the bloodstream, infections that occur after injury or surgery, infections in people with poor circulation, and infection in the bones of the spine. last updated: 7/28/2011

MalaCards: Osteomyelitis is related to arthritis and septic arthritis. An important gene associated with Osteomyelitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Osteoblast Signaling and NF-kappa B signaling pathway. The drug ciprofloxacin and the compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone or, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia:63 Osteomyelitis (sometimes abbreviated to OM, and derived from Greek words osteon, meaning bone, myelo-... more...

Aliases & Classifications for Osteomyelitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteomyelitis 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:1019
MeSH34 D010019
ICD9CM27 730.1, 730.10
ICD1025 M86, M86.9

Related Diseases for Osteomyelitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.9ALPL, LACTB, ACP5, BMP2, CTSK, TNFSF11
2septic arthritis30.8LACTB, ITGA2
3osteopetrosis30.7TNFRSF11A, TNFSF11, CTSK
4synovitis30.5TNFSF11
5osteonecrosis30.3BMP2, ALPL
6leukemia30.1CAT, BMP2, CD40LG, ACP5, LACTB, ALPL
7pneumonia30.1LACTB, FCRL6
8endocarditis30.0LACTB
9psoriasis30.0CCL27
10otitis media29.8LACTB
11osteoporosis29.8IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
12hypophosphatasia29.8ALPL
13prostatitis29.6LACTB
14giant cell tumor29.6TNFSF11, CTSK
15inflammatory bowel disease29.6ALPL
16pancreatitis29.6ALPL
17arthropathy29.6TNFSF11, BMP2, ALPL
18bone carcinoma29.6BMP2, TNFSF11, TNFRSF11A, IBSP
19lupus erythematosus29.6CD40LG
20sarcoma29.6BMP2
21secondary syphilis29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ACP5
22vascular disease29.6CAT, TNFRSF11A, TNFSF11, ITGA2
23osteoarthritis29.6IBSP, TNFRSF11A, TNFSF11, SCG2, CTSK, BMP2
24lung cancer29.6IBSP, TNFRSF11A, TNFSF11, CTSK, BMP2, ITGA2
25osteosarcoma29.6IBSP, CAT, TNFRSF11A, TNFSF11, CTSK, BMP2
26breast cancer29.6IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK, BMP2
27rheumatoid arthritis29.6IBSP, CCL27, TNFRSF11A, TNFSF11, SCG2, CTSK
28epidural abscess10.6
29discitis10.5
30periostitis10.4
31chronic recurrent multifocal osteomyelitis10.4
32sapho syndrome10.4
33chronic granulomatous disease10.4
34cervicitis10.4
35cat-scratch disease10.4
36frontal sinusitis10.4
37acne10.4
38hyperostosis10.4
39pyomyositis10.3
40tuberculosis10.2
41orbital osteomyelitis10.2
42majeed syndrome10.2
43actinomycosis10.2
44meningitis10.2
45otitis externa10.2
46diabetic foot ulcers10.2
47blastomycosis10.2
48mediastinitis10.2
49juvenile chronic recurrent multifocal osteomyelitis10.2
50adult chronic recurrent multifocal osteomyelitis10.2

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to osteomyelitis

Clinical Features for Osteomyelitis

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Drugs & Therapeutics for Osteomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Osteomyelitis

Search NIH Clinical Center for Osteomyelitis

Search CenterWatch for Osteomyelitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Osteomyelitis

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Anatomical Context for Osteomyelitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteomyelitis:

32
Bone, Bone marrow, Spinal cord, Testes, Skin, B cells, Brain, Lymph node, Liver, T cells, Myeloid, Temporal lobe, Prostate, Breast, Lung, Spleen

FMA organs/tissues related to Osteomyelitis:

14
Bone or

Animal Models for Osteomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.5ACP5
2MP:000539010.2ALPL, IBSP, IFNGR1, TNFRSF11A, TNFSF11, CTSK
3MP:000539710.0TNFRSF11A, TNFSF11, CTSK, PPP3CA, ITGA2, CD40LG
4MP:000537910.0CTSK, ITGA2, CD40LG, ALPL
5MP:00053849.9TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2
6MP:00053769.8TNFSF11, TNFRSF11A, IFNGR1, CAT, CTSK, BMP2

Publications for Osteomyelitis

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Sources:
50PubMed
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Articles related to Osteomyelitis:

(show top 50)    (show all 1075)
idTitleAuthorsYear
1
Clostridium difficile vertebral osteomyelitis. (23594589)
2013
2
Two-staged hindfoot reconstruction with vascularized fibula graft for calcaneal osteomyelitis caused by methicillin-resistant Staphylococcus aureus: a case report. (23345037)
2013
3
Establishment of a new methicillin resistant staphylococcus aureus animal model of osteomyelitis. (24170130)
2013
4
Comparison of clinical features and outcomes of staphylococcus aureus vertebral osteomyelitis caused by methicillin-resistant and methicillin-sensitive strains. (23853753)
2013
5
A commentary on "Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease" by R.E. Marx and R. Tursun [Int. J. Oral Maxillofac. Surg. 41 (2012) 283-289]. (23107998)
2013
6
Sacro-iliac osteomyelitis in a 13 year old boy following perforated appendicitis. (23701794)
2013
7
A rabbit osteomyelitis model to simulate multibacterial war wound infections. (23756079)
2013
8
A case report of xanthogranulomatous osteomyelitis of the distal ulna mimicking a malignant neoplasm. (23961304)
2013
9
Clinical-pathological characterization of diabetic foot infections: grading the severity of osteomyelitis. (22582344)
2012
10
Osteomyelitis of a long bone due to Fusobacterium nucleatum and Actinomyces meyeri in an immunocompetent adult: a case report and literature review. (22817336)
2012
11
Sacral colpopexy followed by refractory Candida albicans osteomyelitis and discitis requiring extensive spinal surgery. (22825267)
2012
12
Cryptococcal osteomyelitis and meningitis in a patient with non-hodgkin's lymphoma treated with PEP-C. (22962380)
2012
13
Osteomyelitis of the coxofemoral joint due to Mycobacterium species in a feline renal transplant recipient. (22811480)
2012
14
Primary sternal osteomyelitis in paediatric age: a case report with review of the literature. (23182052)
2012
15
Chronic pelvic osteomyelitis. (22439779)
2012
16
Osteomyelitis and pyomyositis due to Pseudomonas aeruginosa in a child with sickle I^a8^-thalassemia. (21792030)
2011
17
Maxillary osteomyelitis in two Scottish terrier dogs with chronic ulcerative paradental stomatitis. (21916373)
2011
18
Successful management of chronic multifocal Q fever Osteomyelitis with adjuvant interferon-gamma therapy. (21372749)
2011
19
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. (20339868)
2010
20
Osteomyelitis of the scapula with secondary septic arthritis of the shoulder joint. (20200758)
2010
21
Mycobacterium kansasii causing septic arthritis and osteomyelitis in a child. (19884872)
2010
22
Successful treatment of fungal osteomyelitis with voriconazole in a patient with chronic granulomatous disease. (23056752)
2010
23
Prospective evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children. (19568027)
2009
24
Hematogenous infantile infection presenting as osteomyelitis and septic arthritis: a case report. (19830063)
2009
25
Clinical and histopathological features and a unique spectrum of organisms significantly associated with chronic granulomatous disease osteomyelitis during childhood. (18220479)
2008
26
Chronic recurrent multifocal osteomyelitis: what is it and how should it be treated? (18037933)
2007
27
Cervical spinal osteomyelitis with epidural abscess: a rare complication after interferon therapy following acute pyelonephritis. (17635760)
2007
28
Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis. (17885733)
2007
29
Osteomyelitis resulting from chronic filamentous fungus olecranon bursitis. (16357778)
2005
30
Osteomyelitis in diabetic foot ulcers. Prompt diagnosis can avert amputation. (16106914)
2005
31
Mycobacterium marinum osteomyelitis. (12650330)
2003
32
Complex patterns of regulation of chemokine secretion by Th2-cytokines, dexamethasone, and PGE2 in tuberculous osteomyelitis. (12797540)
2003
33
Chronic recurrent multifocal osteomyelitis: review of orthopaedic complications at maturity. (12131448)
2002
34
Differential regulation of chemokine secretion in tuberculous and staphylococcal osteomyelitis. (12211439)
2002
35
Melioidosis splenic abscess--an unusual presentation as osteomyelitis of rib. (11242625)
2001
36
Chronic recurrent multifocal osteomyelitis is a differential diagnosis of juvenile idiopathic arthritis. (11502607)
2001
37
Osteomyelitis complicating osteopetrosis--a case report. (11862853)
2001
38
Hypercoagulopathy with piperacillin administration in osteomyelitis. (10830188)
2000
39
Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis. (10422020)
1999
40
Pediatric case of the day. Tuberculous osteomyelitis with skull involvement and epidural abscess. (10194799)
1999
41
Osteomyelitis and tenosynovitis due to Mycobacterium marinum in a fish dealer. (9409126)
1997
42
Haemophilus aphrophilus bacteraemia complicated with vertebral osteomyelitis and spinal epidural abscess in a patient with liver cirrhosis. (9459409)
1997
43
Chronic recurrent multifocal osteomyelitis with unusual features. (7756816)
1995
44
Sclerosing osteomyelitis of GarrA" (periostitis ossificans). (2371040)
1990
45
Serendipitous diagnosis of childhood xanthogranulomatous pyelonephritis in a child with osteomyelitis. (3550670)
1987
46
Chronic recurrent multifocal osteomyelitis (case report). (3487236)
1986
47
Group C streptococcal arthritis and osteomyelitis in an adolescent with a hereditary sensory neuropathy. (3863096)
1985
48
Acute spreading osteomyelitis of the skull complicating frontal sinusitis. (833490)
1977
49
Treatment of osteomyelitis of the skull resulting from ethmoid and frontal sinusitis. (12995394)
1952
50
Acute Infectious Osteomyelitis and Periostitis. (17857400)
1889

Genetic Variations for Osteomyelitis

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Expression for genes affiliated with Osteomyelitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for genes affiliated with Osteomyelitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Osteomyelitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL27
2procollagen4410.8ACP5, TNFSF11
3strontium ranelate4410.8IBSP, CTSK, TNFSF11
4polyethylene4410.8TNFRSF11A, TNFSF11, CTSK
5alizarin4410.8IBSP, ALPL, BMP2
6tartrate4410.8ACP5, CTSK, TNFSF11
7fibroin4410.7IBSP, BMP2
8titanium4410.7ACP5, BMP2, TNFSF11, IBSP
9zoledronic acid4410.7IBSP, CTSK, TNFSF11, BMP2
10rantes4410.7ACP5, SCG2, CD40LG
11deoxypyridinoline4410.7TNFSF11, CCL27, ACP5, IBSP
12pmma4410.7TNFSF11, CD40LG, ACP5
13methylmethacrylate4410.7IBSP, BMP2
14denosumab44 1111.7TNFRSF11A, TNFSF11
151,25 dihydroxy vitamin d34410.7BMP2, IBSP, TNFRSF11A, TNFSF11, ACP5
16raloxifene44 28 49 1113.7BMP2, TNFSF11, TNFRSF11A
17indomethacin44 59 28 1113.7BMP2
18tetracycline44 1111.7LACTB, ACP5, CD40LG, BMP2
19teriparatide44 1111.7CTSK, TNFSF11
20cycloheximide4410.6CAT, IBSP
21ibandronate44 1111.6TNFSF11, IBSP
22mevalonate4410.6TNFSF11, BMP2, IBSP
23creatinine4410.6CCL27, BMP2, ACP5, IBSP, TNFSF11
24calcitriol44 59 11 2413.6TNFSF11, TNFRSF11A, BMP2, ACP5
25tacrolimus44 49 1112.6PPP3CA, ACP5, TNFSF11, BMP2
26vitamin d4410.6TNFSF11, ALPL, IBSP, ACP5, BMP2
27laccer4410.6TNFSF11, TNFRSF11A
28ascorbic acid44 2411.6CD40LG, BMP2, TNFSF11, CAT, IBSP
29doxycycline44 1111.6CD40LG, LACTB, TNFSF11
30heparin44 28 11 2413.6IBSP, TNFSF11, CD40LG, ITGA2, BMP2, ACP5
31cyclosporin a44 28 5912.6ACP5, PPP3CA, CD40LG, BMP2, TNFSF11
32aspartate4410.6CD40LG, ITGA2, ALPL, ACP5, CCL27, CTSK
33oxygen44 2411.6IFNGR1, TNFSF11, TNFRSF11A, BMP2, ACP5, ITGA2
34vancomycin44 1111.5CD40LG, LACTB
35hydroxyapatite4410.5IBSP, CCL27, TNFRSF11A, TNFSF11, CTSK, BMP2
36vegf4410.5ITGA2, CD40LG, IBSP, TNFRSF11A, TNFSF11, SCG2
37polyethylene glycol4410.5CD40LG, BMP2, ACP5
38grgdsp4410.5IBSP, ITGA2
39dexamethasone44 49 28 1113.5IBSP, SCG2, TNFRSF11A, ACP5, CD40LG, BMP2
40nitric oxide44 11 2412.5ITGA2, CAT, TNFRSF11A, ACP5, BMP2, TNFSF11
41lipid4410.4TNFRSF11A, TNFSF11, BMP2, ITGA2, ACP5, IBSP
42cysteine4410.4CAT, ACP5, IBSP, TNFSF11, SCG2, CTSK
43tyrosine4410.4ACP5, ITGA2, CTSK, SCG2, TNFRSF11A, TNFSF11
44fibrinogen4410.4IBSP, PPP3CA, CD40LG, ITGA2
45gp 1304410.4TNFSF11, TNFRSF11A, IFNGR1
46azathioprine44 49 2 1113.3BMP2, TNFSF11, ACP5
47calcium44 49 11 2413.3TNFSF11, TNFRSF11A, IBSP, CTSK, SCG2, BMP2
48rapamycin4410.3CD40LG, ACP5, BMP2, TNFSF11
49latex4410.2ITGA2, TNFSF11, IBSP
50amoxicillin44 49 1112.0LACTB, CD40LG

GO Terms for genes affiliated with Osteomyelitis

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16Gene Ontology
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Cellular components related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCRL6, CD40LG, ITGA2, TNFRSF11A
2extracellular spaceGO:0056159.7ALPL, CCL27, TNFSF11, SCG2, CTSK, BMP2

Biological processes related to Osteomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.6TNFRSF11A, TNFSF11
3bone resorptionGO:04545310.6ACP5, CTSK, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.6TNFRSF11A, TNFSF11
5ossificationGO:00150310.5TNFSF11, TNFRSF11A, IBSP
6extracellular matrix organizationGO:03019810.4IBSP, CTSK, BMP2, ITGA2
7organ morphogenesisGO:00988710.4ITGA2, BMP2, TNFSF11
8mammary gland alveolus developmentGO:06074910.4TNFSF11, TNFRSF11A
9response to lipopolysaccharideGO:03249610.3ALPL, ACP5, TNFRSF11A
10positive regulation of NF-kappaB transcription factor activityGO:05109210.2CAT, TNFRSF11A, TNFSF11
11monocyte chemotaxisGO:00254810.1TNFSF11, TNFRSF11A

Molecular functions related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.4TNFRSF11A, IFNGR1
2cytokine activityGO:0051259.9CD40LG, BMP2, SCG2, TNFSF11

Products for genes affiliated with Osteomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet