MCID: OST017
MIFTS: 53

Osteomyelitis malady

Summaries for Osteomyelitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Osteomyelitis is the medical term for an infection in a bone. the infection that causes osteomyelitis often is in another part of the body and spreads to the bone via the blood. affected bone may have been predisposed to infection because of recent trauma. in children, the long bones are usually affected. in adults, the vertebrae and the pelvis are most commonly affected. bone infection can be caused by bacteria or by fungus. osteomyelitis is divided into several types depending on where an infection begins and where it occurs. types of osteomyelitis include: infections that travel through the bloodstream, infections that occur after injury or surgery, infections in people with poor circulation, and infection in the bones of the spine. last updated: 7/28/2011

MalaCards: Osteomyelitis is related to arthritis and septic arthritis. An important gene associated with Osteomyelitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Osteoblast Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drug ciprofloxacin and the compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone or, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia:64 Osteomyelitis (sometimes abbreviated to OM, and derived from Greek words osteon, meaning bone, myelo-... more...

Aliases & Classifications for Osteomyelitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Osteomyelitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.9TNFRSF11A, CTSK, BMP2, ALPL, ACP5, LACTB
2septic arthritis30.8LACTB, ITGA2
3osteopetrosis30.8CTSK, TNFSF11, TNFRSF11A
4sinusitis30.6LACTB
5synovitis30.5TNFSF11
6osteonecrosis30.4BMP2, ALPL
7bacteremia30.1CAT, LACTB
8osteoporosis29.9ACP5, BMP2, TNFSF11, TNFRSF11A, IBSP, CTSK
9hypophosphatasia29.9ALPL
10arthropathy29.7BMP2, TNFSF11, ALPL
11bone carcinoma29.7TNFRSF11A, BMP2, TNFSF11, IBSP
12secondary syphilis29.7IBSP, BMP2, CTSK, TNFSF11, TNFRSF11A, ACP5
13vascular disease29.7ITGA2, CAT, TNFRSF11A, TNFSF11
14osteoarthritis29.7IBSP, TNFRSF11A, TNFSF11, CTSK, SCG2, BMP2
15chronic recurrent multifocal osteomyelitis10.9
16epidural abscess10.6
17discitis10.6
18sapho syndrome10.4
19chronic granulomatous disease10.4
20acne10.4
21mycobacterium fortuitum10.4
22pyomyositis10.3
23tuberculosis10.3
24orbital osteomyelitis10.2
25majeed syndrome10.2
26actinomycosis10.2
27adult chronic recurrent multifocal osteomyelitis10.2
28diabetic foot ulcers10.2
29blastomycosis10.2
30mycobacterium chelonae10.2
31mycobacterium kansasii10.2
32juvenile chronic recurrent multifocal osteomyelitis10.2
33malignant otitis externa10.1
34melioidosis10.1
35pycnodysostosis10.1
36n syndrome10.1
37mycobacterium marinum10.1
38synovitis, chronic10.1
39subdural empyema10.1
40cellulitis10.1
41bone lymphoma10.1
42acute frontal sinusitis10.1
43sickle cell disease10.1
44chronic pain10.1
45sepsis10.1
46sickle cell anemia10.0
47reactive arthritis10.0
48ulcerative colitis10.0
49pyoderma gangrenosum10.0
50chickenpox10.0

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to osteomyelitis

Clinical Features for Osteomyelitis

Drugs & Therapeutics for Osteomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteomyelitis

Drug clinical trials:

Search ClinicalTrials for Osteomyelitis

Search NIH Clinical Center for Osteomyelitis

Search CenterWatch for Osteomyelitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Osteomyelitis

Anatomical Context for Osteomyelitis

Sources:
14FMA
See all sources

FMA organs/tissues related to Osteomyelitis:

14
Bone or

Animal Models for Osteomyelitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Osteomyelitis

Sources:
51PubMed
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Articles related to Osteomyelitis:

(show top 50)    (show all 1076)
idTitleAuthorsYear
1
An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis. (23899021)
2013
2
Chronic recurrent multifocal osteomyelitis in a 13 year old female athlete: a case report. (24302781)
2013
3
Ectopic mandibular third molar leading to osteomyelitis of condyle: a case report with literature review. (22847038)
2013
4
Chronic recurrent multifocal osteomyelitis and deficiency of interleukin-1-receptor antagonist. (23241992)
2013
5
Osteomyelitis complicating scleroderma digital ulcers. (23307325)
2013
6
Bacteroides fragilis vertebral osteomyelitis complicated by percutaneous epidural adhesiolysis. (23324937)
2013
7
The management gram-negative bacterial haematogenous vertebral osteomyelitis: a case series of diagnosis, treatment and therapeutic outcomes. (23543389)
2013
8
Exposed bone in bisphosphonate-related osteonecrosis of the jaws may be induced and maintained by localized microbial biofilm osteomyelitis. (24128706)
2013
9
In vivo caprine model for osteomyelitis and evaluation of biofilm-resistant intramedullary nails. (23841085)
2013
10
Dilemma in differentiating between acute osteomyelitis and bone infarction in children with sickle cell disease: the role of ultrasound. (23755165)
2013
11
Primary cervical osteomyelitis. (24025539)
2013
12
Ewing sarcoma versus osteomyelitis: differential diagnosis with magnetic resonance imaging. (23685708)
2013
13
A case of rib fungal osteomyelitis. (24183385)
2013
14
Cervical osteomyelitis after placement of a self-expanding plastic stent for palliation of dysphagia associated with chemoradiation-induced esophageal strictures. (22367919)
2013
15
An unusual sacral osteomyelitis due to an occult anterior sacral meningocele. (23034886)
2013
16
A case of IgM deficiency with B cell deficiency detected by ABO discrepancy in a patient with acute osteomyelitis. (23667850)
2013
17
Stage 3 pyomyositis of the gluteus minimus; Staphylococcus aureus sepsis, autoanticoagulation, proximal femoral osteomyelitis and the role of surgical intervention. (24293538)
2013
18
Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. (23263195)
2013
19
Fulminant spread of a femur anaerobic osteomyelitis to abdomen in a 17-year-old boy. (22482093)
2012
20
Nonabsorbable-suture-induced osteomyelitis: a case report and review of the literature. (23259121)
2012
21
Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis. (22722588)
2012
22
Osteomyelitis of zygoma in a schizophrenia patient. (22761207)
2012
23
Four-flap compound repair of thoracic hernia after sternum osteomyelitis and omentum flap. (22938781)
2012
24
Daptomycin compared to vancomycin for the treatment of osteomyelitis: a single-center, retrospective cohort study. (22748973)
2012
25
Central skull base osteomyelitis as a complication of necrotizing otitis externa: Imaging findings, complications, and challenges of diagnosis. (22483946)
2012
26
Sternal osteomyelitis caused by Aspergillus fumigatus following cardiac surgery: Case and review. (24432203)
2012
27
Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty. (22908174)
2012
28
Recurrent chronic suppurative osteomyelitis of the mandible and human immunodeficiency virus infection. (23059590)
2012
29
Successful surgical and medical treatment of rhizopus osteomyelitis following hematopoietic cell transplantation. (23027498)
2012
30
A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia. (22824200)
2012
31
Evidences and controversies about recurrence of diabetic foot osteomyelitis: a personal view and an illustrated guide for understanding. (22538269)
2012
32
Cryptococcal osteomyelitis of the skull in a patient with transient lymphopenia. (20508355)
2010
33
Diffuse chronic sclerosing osteomyelitis of the mandible with synovitis, acne, pustulosis, hyperostosis, and osteitis: report of a long-term follow-up case. (20006181)
2010
34
Cranial melioidosis presenting as a mass lesion or osteomyelitis. (18240918)
2008
35
Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis. (18971305)
2008
36
Disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess. (16351038)
2005
37
Chronic recurrent multifocal osteomyelitis: two cases of sacral disease responsive to corticosteroids. (15712088)
2005
38
Tuberculous osteomyelitis of the lumbosacral region: a spinal epidural abscess with presacral extension. (15069571)
2004
39
Skull base osteomyelitis secondary to malignant otitis externa. (14502060)
2003
40
Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. (12183714)
2002
41
Osteomyelitis mimicking a primary bone tumor in a patient with pulmonary arteriovenous malformation and Osler-Weber-Rendu disease. (15290578)
2002
42
Ureteral obstruction as a complication of vertebral osteomyelitis and discitis: a patient report. (12462326)
2002
43
Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22. (11973628)
2002
44
Chronic recurrent multifocal osteomyelitis: report of a case. (1554846)
1992
45
Osteomyelitis and intervertebral discitis caused by Pseudomonas pickettii. (1401027)
1992
46
Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. (3166878)
1988
47
Chronic recurrent multifocal osteomyelitis: a follow-up study. (3335622)
1988
48
Anatomic basis for the pathogenesis and radiologic features of vertebral osteomyelitis and its differentiation from childhood discitis. A microarteriographic investigation. (3993417)
1985
49
Sickle cell-hemoglobin C disease and pregnancy, including a case of osteomyelitis. (13649807)
1959
50
Case of bilateral frontal sinusitis, with osteomyelitis of the frontal bone and left antral sinusitis, treated with penicillin. (20287759)
1946

Genetic Variations for Osteomyelitis

Expression for genes affiliated with Osteomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for genes affiliated with Osteomyelitis

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Osteomyelitis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pge24510.9CCL27
2procollagen4510.8ACP5, TNFSF11
3strontium ranelate4510.8IBSP, CTSK, TNFSF11
4polyethylene4510.8TNFRSF11A, TNFSF11, CTSK
5alizarin4510.8IBSP, ALPL, BMP2
6tartrate4510.8ACP5, CTSK, TNFSF11
7fibroin4510.7IBSP, BMP2
8titanium4510.7ACP5, BMP2, TNFSF11, IBSP
9zoledronic acid4510.7IBSP, CTSK, TNFSF11, BMP2
10rantes4510.7ACP5, SCG2, CD40LG
11deoxypyridinoline4510.7TNFSF11, CCL27, ACP5, IBSP
12pmma4510.7TNFSF11, CD40LG, ACP5
13methylmethacrylate4510.7IBSP, BMP2
14denosumab45 1111.7TNFRSF11A, TNFSF11
151,25 dihydroxy vitamin d34510.7BMP2, IBSP, TNFRSF11A, TNFSF11, ACP5
16raloxifene45 29 50 1113.7BMP2, TNFSF11, TNFRSF11A
17indomethacin45 60 29 1113.7BMP2
18tetracycline45 1111.7LACTB, ACP5, CD40LG, BMP2
19teriparatide45 1111.7CTSK, TNFSF11
20cycloheximide4510.6CAT, IBSP
21ibandronate45 1111.6TNFSF11, IBSP
22mevalonate4510.6TNFSF11, BMP2, IBSP
23creatinine4510.6CCL27, BMP2, ACP5, IBSP, TNFSF11
24calcitriol45 60 11 2413.6TNFSF11, TNFRSF11A, BMP2, ACP5
25tacrolimus45 50 1112.6PPP3CA, ACP5, TNFSF11, BMP2
26vitamin d4510.6TNFSF11, ALPL, IBSP, ACP5, BMP2
27laccer4510.6TNFSF11, TNFRSF11A
28ascorbic acid45 2411.6CD40LG, BMP2, TNFSF11, CAT, IBSP
29doxycycline45 1111.6CD40LG, LACTB, TNFSF11
30heparin45 29 11 2413.6IBSP, TNFSF11, CD40LG, ITGA2, BMP2, ACP5
31cyclosporin a45 29 6012.6ACP5, PPP3CA, CD40LG, BMP2, TNFSF11
32aspartate4510.6CD40LG, ITGA2, ALPL, ACP5, CCL27, CTSK
33oxygen45 2411.6IFNGR1, TNFSF11, TNFRSF11A, BMP2, ACP5, ITGA2
34vancomycin45 1111.5CD40LG, LACTB
35hydroxyapatite4510.5IBSP, CCL27, TNFRSF11A, TNFSF11, CTSK, BMP2
36vegf4510.5ITGA2, CD40LG, IBSP, TNFRSF11A, TNFSF11, SCG2
37polyethylene glycol4510.5CD40LG, BMP2, ACP5
38grgdsp4510.5IBSP, ITGA2
39dexamethasone45 50 29 1113.5IBSP, SCG2, TNFRSF11A, ACP5, CD40LG, BMP2
40nitric oxide45 11 2412.5ITGA2, CAT, TNFRSF11A, ACP5, BMP2, TNFSF11
41lipid4510.4TNFRSF11A, TNFSF11, BMP2, ITGA2, ACP5, IBSP
42cysteine4510.4CAT, ACP5, IBSP, TNFSF11, SCG2, CTSK
43tyrosine4510.4ACP5, ITGA2, CTSK, SCG2, TNFRSF11A, TNFSF11
44fibrinogen4510.4IBSP, PPP3CA, CD40LG, ITGA2
45gp 1304510.4TNFSF11, TNFRSF11A, IFNGR1
46azathioprine45 50 2 1113.3BMP2, TNFSF11, ACP5
47calcium45 50 11 2413.3TNFSF11, TNFRSF11A, IBSP, CTSK, SCG2, BMP2
48rapamycin4510.3CD40LG, ACP5, BMP2, TNFSF11
49latex4510.2ITGA2, TNFSF11, IBSP
50amoxicillin45 50 1112.0LACTB, CD40LG

GO Terms for genes affiliated with Osteomyelitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCRL6, CD40LG, ITGA2, TNFRSF11A
2extracellular spaceGO:0056159.7ALPL, CCL27, TNFSF11, SCG2, CTSK, BMP2

Biological processes related to Osteomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.6TNFRSF11A, TNFSF11
3bone resorptionGO:04545310.6ACP5, CTSK, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.6TNFRSF11A, TNFSF11
5ossificationGO:00150310.5TNFSF11, TNFRSF11A, IBSP
6extracellular matrix organizationGO:03019810.4IBSP, CTSK, BMP2, ITGA2
7organ morphogenesisGO:00988710.4ITGA2, BMP2, TNFSF11
8mammary gland alveolus developmentGO:06074910.4TNFSF11, TNFRSF11A
9response to lipopolysaccharideGO:03249610.3ALPL, ACP5, TNFRSF11A
10positive regulation of NF-kappaB transcription factor activityGO:05109210.2CAT, TNFRSF11A, TNFSF11
11monocyte chemotaxisGO:00254810.1TNFSF11, TNFRSF11A

Molecular functions related to Osteomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:01995510.4TNFRSF11A, IFNGR1
2cytokine activityGO:0051259.9CD40LG, BMP2, SCG2, TNFSF11

Products for genes affiliated with Osteomyelitis

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Sources for Osteomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet