Aliases & Classifications for Osteomyelitis

MalaCards integrated aliases for Osteomyelitis:

Name: Osteomyelitis 12 50 29 52 14 69

Classifications:



Summaries for Osteomyelitis

NIH Rare Diseases : 50 osteomyelitis is the medical term for an infection in a bone. signs and symptoms vary but may include bone pain, fever, chills, excessive sweating, malaise, or an open wound. people with the condition may also experience local swelling, redness, and warmth at the site of the infection. although any bone in the body can be affected, the long bones of the arms and legs are most commonly infected in children, while the feet, spine bones, and hips are primarily affected in adults. osteomyelitis is most often caused by a bacterial infection, although it can also be caused by a fungal infection. risk factors for the condition include diabetes, poor blood supply, recent injury, intravenous drug abuse, surgery involving the bones, and a weakened immune system. the goal of treatment is to cure the infection and reduce damage to the bone and surrounding tissues. this may include medications to treat the infection and surgery to drain, clean and/or remove dead bone tissue. last updated: 10/19/2016

MalaCards based summary : Osteomyelitis is related to orbital osteomyelitis and melioidosis, and has symptoms including pain in limb and bone pain. An important gene associated with Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ciprofloxacin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A bone inflammation disease that has material basis in infection located in bone or located in bone marrow.

Wikipedia : 72 Osteomyelitis (OM) is an infection of bone. Symptom may include pain in a specific bone with overlying... more...

Related Diseases for Osteomyelitis

Diseases related to Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)
id Related Disease Score Top Affiliating Genes
1 orbital osteomyelitis 32.8 IFNG IL6 TNF TNFSF11
2 melioidosis 30.3 IFNG IL6 TNF
3 lymphoma 30.1 IFNG IL1B IL6 TNF
4 pyelonephritis 29.8 CXCL8 IL1B TNF
5 hemophagocytic lymphohistiocytosis 29.7 IFNG IL6 TNF
6 sinusitis 29.5 CXCL8 IL1A IL1B IL1RN TNF
7 neuropathy 29.5 IL1A TNF TNFSF11
8 degenerative disc disease 29.3 IFNG IL1B IL6 TNF
9 dysphagia 29.1 CXCL8 IFNG IL6 TNF
10 keloids 28.7 IL1B IL1RN IL6 TNF TNFSF11
11 osteochondrosis 28.3 CXCL8 IL1B IL6 TNF TNFSF11
12 rheumatoid arthritis 25.4 ACP5 CTSK CXCL8 IFNG IL1A IL1B
13 chronic recurrent multifocal osteomyelitis 12.5
14 majeed syndrome 11.8
15 sapho syndrome 11.5
16 interleukin 1 receptor antagonist deficiency 11.5
17 mycobacterium fortuitum 11.0
18 petrositis 11.0
19 neuropathy, hereditary sensory, type if 10.8
20 neuropathy, hereditary sensory and autonomic, type ic 10.8
21 gastric cancer risk after h. pylori infection 10.8 IL1B IL1RN
22 intracranial aneurysms multiple congenital anomaly 10.7 IFNG IFNGR1
23 crystal arthropathies 10.7 IL1RN IL6
24 neuropathy, hereditary sensory and autonomic, type iib 10.7
25 immunodeficiency 27b, mycobacteriosis, ad 10.7
26 insensitivity to pain, congenital, with anhidrosis 10.7
27 amyloidosis aa 10.7
28 neuropathy, hereditary sensory and autonomic, type ia 10.7
29 mitochondrial dna depletion syndrome 6 10.7
30 psoriasis 14, pustular 10.7
31 gnathodiaphyseal dysplasia 10.7
32 phaeohyphomycosis 10.7
33 toxic shock syndrome 10.7
34 shoulder impingement syndrome 10.7 IL1RN IL6
35 smarca4-deficient sarcoma of thorax 10.7 IL6 TNF
36 tabatznik syndrome 10.6 IL1B TNF
37 crohn disease-associated growth failure 10.6 IL6 SPTLC1
38 toxic optic neuropathy 10.6 IL1A IL1B
39 aortic arch interruption 10.6 IL6 TNF
40 dermatitis herpetiformis, familial 10.6 IFNG IL1RN IL6
41 walker dyson syndrome 10.6 IL1B IL1RN TNF
42 cutaneous leishmaniasis 10.6 IL6 TNF
43 autoimmune polyglandular syndrome type 3 10.5 IFNG TNF
44 mental retardation dysmorphism hypogonadism diabetes 10.5 IL1A IL1B IL1RN
45 sternal cleft 10.5 IFNG IL1B TNF
46 upper gum cancer 10.5 IL1B IL6 TNF
47 bipolar i disorder 10.5 IL1B IL6 TNF
48 early congenital syphilis 10.5 IL1RN IL6 TNF
49 tinea favosa 10.5 IL1B IL6 TNF
50 central nervous system leiomyosarcoma 10.5 IL1B IL6 TNF

Comorbidity relations with Osteomyelitis via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Osteomyelitis:



Diseases related to Osteomyelitis

Symptoms & Phenotypes for Osteomyelitis

UMLS symptoms related to Osteomyelitis:


pain in limb, bone pain

MGI Mouse Phenotypes related to Osteomyelitis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 BMP2 CASP1 CTSK IFNG IFNGR1 IL1A
2 hematopoietic system MP:0005397 10.27 BMP2 CASP1 CTSK IFNG IFNGR1 IL1A
3 immune system MP:0005387 10.22 TNF TNFSF11 BMP2 CASP1 CTSK IFNG
4 cardiovascular system MP:0005385 10.19 IL1RN IL6 LPIN2 TNF BMP2 CASP1
5 mortality/aging MP:0010768 10.1 IL1RN IL6 LPIN2 PPP3CA SPTLC1 TNF
6 digestive/alimentary MP:0005381 10.02 BMP2 CASP1 CTSK IFNG IFNGR1 IL6
7 integument MP:0010771 10.02 CASP1 IFNG IFNGR1 IL1A IL1B IL1RN
8 nervous system MP:0003631 9.9 BMP2 CASP1 CTSK IFNG IFNGR1 IL1B
9 neoplasm MP:0002006 9.86 CASP1 IFNG IFNGR1 IL1A IL1B IL6
10 reproductive system MP:0005389 9.61 TNFSF11 IL6 SPTLC1 TNF BMP2 CASP1
11 skeleton MP:0005390 9.28 BMP2 CTSK IFNG IFNGR1 IL1B IL1RN

Drugs & Therapeutics for Osteomyelitis

Drugs for Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Early Phase 1 85721-33-1 2764
2
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 738-70-5 5578
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
5
Vancomycin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1404-90-6 441141 14969
6
Cefepime Approved Phase 4,Phase 2,Early Phase 1 88040-23-7 5479537
7
Cefotaxime Approved Phase 4,Early Phase 1 63527-52-6 456256 5742673
8
Cefoxitin Approved Phase 4,Early Phase 1 35607-66-0 441199
9
Ceftriaxone Approved Phase 4,Early Phase 1 73384-59-5 5479530 5361919
10
Doxycycline Approved, Investigational, Vet_approved Phase 4,Early Phase 1 564-25-0 54671203
11
Fusidic Acid Approved Phase 4,Phase 2,Phase 3 6990-06-3 3000226
12
Levofloxacin Approved, Investigational Phase 4,Early Phase 1 100986-85-4 149096
13
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 165800-03-3 441401
14
Ofloxacin Approved Phase 4,Early Phase 1 82419-36-1 4583
15
Rifampin Approved Phase 4,Early Phase 1 13292-46-1 5458213 5381226
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 58-05-9 143 6006
18
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Antimalarials Phase 4,Phase 3,Phase 2,Early Phase 1
23 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
24 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
25 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2,Early Phase 1
26 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
27 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
28 Renal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
29 Topoisomerase Inhibitors Phase 4,Phase 2,Early Phase 1
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3,Phase 2,Early Phase 1
31 Vitamin B Complex Phase 4,Phase 3,Phase 2,Early Phase 1
32 methicillin Phase 4,Phase 3,Early Phase 1
33 Antitubercular Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 Cytochrome P-450 CYP3A Inducers Phase 4,Early Phase 1
35 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
36 Gentamicins Phase 4,Early Phase 1
37 Cephalosporins Phase 4,Phase 1,Phase 2
38 Dermatologic Agents Phase 4
39 Micronutrients Phase 4
40 Photosensitizing Agents Phase 4
41 Trace Elements Phase 4
42 Vitamins Phase 4
43 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
44 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
45 Vitamin B2 Nutraceutical Phase 4
46
Amoxicillin Approved, Vet_approved Phase 3,Early Phase 1 26787-78-0 33613 2171
47
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
48
Nafcillin Approved Phase 3,Phase 2,Early Phase 1 985-16-0, 147-52-4 8982
49
Ertapenem Approved, Investigational Phase 3 153832-46-3 150610
50
Minocycline Approved, Investigational Phase 3,Early Phase 1 10118-90-8 5281021

Interventional clinical trials:

(show top 50) (show all 76)

id Name Status NCT ID Phase Drugs
1 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
2 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
3 CERAMENT™|G - Bone Healing and Re-infection Prophylaxis Recruiting NCT02128256 Phase 4
4 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
5 Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics Not yet recruiting NCT03012529 Phase 4 Rifampin;Riboflavin Placebo
6 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
7 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
8 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
9 Use of Santyl Within an Accountable Care Organization Withdrawn NCT02716519 Phase 4
10 Platelet Gel in Systemic Sclerosis Unknown status NCT00463125 Phase 2, Phase 3 Platelet Gel
11 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
12 Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis. Completed NCT00366249 Phase 3 Tigecycline;Ertapenem
13 Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers Completed NCT01586481 Phase 3
14 Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) Completed NCT01370616 Phase 3 Ertapenem sodium;Piperacillin/tazobactam sodium;Piperacillin/tazobactam-matching placebo;Amoxicillin/clavulunate potassium
15 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Recruiting NCT03174366 Phase 3 Denosumab
16 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
17 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
18 Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Withdrawn NCT02344511 Phase 3 Dalbavancin;cefazolin, nafcillin, oxacillin or vancomycin
19 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
20 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci Completed NCT00428844 Phase 2 daptomycin;daptomycin;vancomycin;teicoplanin;nafcillin;oxacillin;flucloxacillin
21 Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for the Treatment of Diabetic Foot Osteomyelitis Recruiting NCT02168816 Phase 2 piperacillin/tazobactam, cefepime, metronidazole, aztreonam,vancomycin, daptomycin, linezolid ,meropenem;sulfamethoxazole/trimethoprim , clindamycin ,linezolid, moxifloxacin ,ciprofloxacin ,metronidazole
22 Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children Recruiting NCT02335905 Phase 1, Phase 2 Ceftaroline Fosamil
23 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Recruiting NCT02594878 Phase 2 Pamidronatdinatrium
24 Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration Recruiting NCT02842619 Phase 1, Phase 2
25 Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections Recruiting NCT03009045 Phase 2 Tedizolid
26 Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Subjects With Osteomyelitis Active, not recruiting NCT02685033 Phase 2 Dalbavancin;Comparator
27 Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis Terminated NCT03091439 Phase 2 Dalbavancin;Standard-of-Care
28 [124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection Terminated NCT01764919 Phase 2
29 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
30 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis Unknown status NCT02165579
31 Detection of Osteomyelitis Using High Resolution Ultrasound Unknown status NCT02198755
32 Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus (MRSA) Osteomyelitis (VOTSMO) Unknown status NCT00324922 trimethoprim-sulfamethoxazole;vancomycin
33 Efficacy of Surgical Treatment of Osteomyelitis in Diabetic Foot Ulcers Unknown status NCT01137903 Ciprofloxacin;Amoxicillin-Potassium Clavulanate Combination;Sulfamethoxazole trimethoprim
34 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979
35 Characterizing and Diagnosis’s of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients Unknown status NCT00157222
36 Use of Hand Prosthesis With Direct Nerve Stimulation for Treatment of Phantom Limb Pain Unknown status NCT02506608
37 Clinical Evaluation of Daptomycin Bone Penetration Unknown status NCT01306825
38 Computed Tomography (CT) Score and Histopathology of the Middle Turbinate in Chronic Rhinosinusitis Unknown status NCT00899561
39 Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT) Completed NCT02308774
40 Characterization and Differential Diagnosis of Vertebral Osteomyelitis Completed NCT01125839
41 Risk Factors for Three Critical Stages of the Diabetic Foot Infections Completed NCT02736253
42 Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ Completed NCT01670422
43 Drug Delivery Devices for Osteomyelitis Completed NCT02968693 Vancomycin
44 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
45 Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections Completed NCT02311452
46 Bisphosphonate-Associated Jaw Osteonecrosis and PET Imaging Completed NCT00592982
47 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
48 Biofilm Formation in Staphylococcus Epidermidis Associated Implant Infections Completed NCT02640937
49 A Retrospective Analysis of Patients With Full Thickness Wounds in Limbs With Critical Ischemia Completed NCT00760357
50 Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Children in the Paediatric A&E. Completed NCT01396798

Search NIH Clinical Center for Osteomyelitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Osteomyelitis

Genetic tests related to Osteomyelitis:

id Genetic test Affiliating Genes
1 Osteomyelitis 29

Anatomical Context for Osteomyelitis

MalaCards organs/tissues related to Osteomyelitis:

39
Bone, Bone Marrow, Testes, Spinal Cord, Skin, Lung, Liver

Publications for Osteomyelitis

Articles related to Osteomyelitis:

(show top 50) (show all 1375)
id Title Authors Year
1
A link between osteomyelitis and IL1RN and IL1B polymorphisms-a study in patients from Northeast Brazil. ( 28682145 )
2017
2
Chronic Osteomyelitis of the Distal Femur Treated with Resection and Delayed Endoprosthetic Reconstruction: A Report of Three Cases. ( 28894615 )
2017
3
Multifocal Recurrent Osteomyelitis and Hemophagocytic Lymphohistiocytosis in a Boy with Partial Dominant IFN-I^R1 Deficiency: Case Report and Review of the Literature. ( 28516082 )
2017
4
Diskitis, Osteomyelitis, Spinal Epidural Abscess, Meningitis, and Endocarditis Following Sacroiliac Joint Injection for the Treatment of Low-Back Pain in a Patient on Therapy for Hepatitis C Virus. ( 28492440 )
2017
5
Osteomyelitis due to Mycobacterium kansasii in a patient with sarcoidosis. ( 28529884 )
2017
6
Osteomyelitis and arthritis caused by Mycobacterium intracellulare: an underestimated diagnosis. ( 28911365 )
2017
7
Osteomyelitis Risk in Patients With Transfemoral Amputations Treated With Osseointegration Prostheses. ( 28940152 )
2017
8
Clostridium sphenoides Chronic Osteomyelitis Diagnosed Via Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, Conflicting With 16S rRNA Sequencing but Confirmed by Whole Genome Sequencing. ( 28051992 )
2017
9
Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats. ( 28064219 )
2017
10
Complications during the treatment of diabetic foot osteomyelitis. ( 28951333 )
2017
11
Chronic recurrent multifocal osteomyelitis presenting with Tolosa-Hunt syndrome in a 13-year-old boy. ( 28598320 )
2017
12
Chronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy. ( 28656169 )
2017
13
Osteomyelitis of the foot: non-surgical management, SPECT/CT scanning and minimising the duration of antibiotic use. ( 28936764 )
2017
14
Chronic recurrent multifocal osteomyelitis exhibiting predominance of periosteal reaction. ( 28614530 )
2017
15
Oral alendronate in pediatric chronic recurrent multifocal osteomyelitis. ( 28401741 )
2017
16
Correction: Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO). ( 28686717 )
2017
17
Blood perfusion in osteomyelitis studied with [(15)O]water PET in a juvenile porcine model. ( 28091979 )
2017
18
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
19
Pediatric chronic osteomyelitis in the outskirts of Al-Ushbuna (Carnide, Lisboa, Portugal). ( 28888386 )
2017
20
Pubic osteomyelitis after surgery for perforated colonic diverticulitis with fecal peritonitis: A case report. ( 28735117 )
2017
21
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
22
Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis. ( 28361334 )
2017
23
Persistent Fever in Medical Intensive Care Unit: Evans Syndrome Versus Actinomycotic Osteomyelitis? ( 28092284 )
2017
24
[Retropharyngeal abscess with cervical discitis and vertebral osteomyelitis caused by Escherichia coli in a patient with liver cirrhosis]. ( 28603238 )
2017
25
Chronic recurrent multifocal osteomyelitis in children and adults: current understanding and areas for development. ( 28486628 )
2017
26
Primary Tuberculotic Osteomyelitis of Rib in a Child. ( 28892970 )
2017
27
A novel case of Raoultella planticola osteomyelitis and epidural abscess. ( 28705846 )
2017
28
Surgical treatment of stage 2 medication-related osteonecrosis of the jaw compared to osteomyelitis. ( 28854059 )
2017
29
Acute osteomyelitis and septic arthritis in children : AA referral hospital-based study in Iran. ( 28744778 )
2017
30
Atypical osteomyelitis and concurrent septic arthritis due to Salmonella in immunocompetent children. ( 28951650 )
2017
31
Management of the Pressure Injury Patient with Osteomyelitis: An Algorithm. ( 28882682 )
2017
32
Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study. ( 28862129 )
2017
33
Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats. ( 28884090 )
2017
34
Chronic Recurrent Multifocal Osteomyelitis: A Case Report with Atypical Presentation. ( 28630846 )
2017
35
Detecting chronic post-traumatic osteomyelitis of mouse tibia via an IL-13RI+2 targeted metallofullerene magnetic resonance imaging probe. ( 28061526 )
2017
36
An uncommon cause of sciatic pain: tuberculous osteomyelitis of the ischial tuberosity. ( 28074705 )
2017
37
Two stage management of Cierny-Mader type IV chronic osteomyelitis of the long bones. ( 28088375 )
2017
38
Epidemiological, bacteriological and therapeutic aspects of chronic osteomyelitis in a sub-Saharan environment. ( 28947406 )
2017
39
A Case of Osteomyelitis of the toe caused by Coccidioidomycosis in a 17 year-old with Diabetes Insipidus. ( 28560172 )
2017
40
Primary subacute epiphyseal osteomyelitis caused by Mycobacterium species in young children: a modern diagnostic approach. ( 28054229 )
2017
41
Lytic Bone Lesions: Osteomyelitis or Intraosseous Gout? ( 28864666 )
2017
42
Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot. ( 28696850 )
2017
43
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
44
Utility of Three-phase Skeletal Scintigraphy with Single Photon Emission Computed Tomography/Computed Tomography in a Case of Chronic Recurrent Multifocal Osteomyelitis. ( 28680224 )
2017
45
Vertebral osteomyelitis as a rare manifestation of Lemierre's syndrome. ( 28879094 )
2017
46
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
47
Arthrocladium fulminans Arthritis and Osteomyelitis. ( 28070004 )
2017
48
Classical Hodgkin lymphoma masquerading as chronic recurrent multifocal osteomyelitis: a case report. ( 28212666 )
2017
49
An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children. ( 28401420 )
2017
50
Congenital lumbar kyphosis with skin ulceration and osteomyelitis in a myelomeningocele child: a case report. ( 28918465 )
2017

Variations for Osteomyelitis

Expression for Osteomyelitis

Search GEO for disease gene expression data for Osteomyelitis.

Pathways for Osteomyelitis

Pathways related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CASP1 CTSK CXCL8 IFNG IFNGR1 IL1A
2
Show member pathways
13.72 BMP2 CASP1 CXCL8 IFNG IFNGR1 IL1A
3
Show member pathways
13.58 BMP2 CXCL8 IFNG IFNGR1 IL1A IL1B
4
Show member pathways
13.43 BMP2 CXCL8 IL1A IL1B IL6 TNF
5
Show member pathways
13.41 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
6
Show member pathways
13.36 BMP2 CASP1 CXCL8 IL1A IL1B IL6
7
Show member pathways
13.06 CASP1 CXCL8 IL1A IL1B IL1RN IL6
8
Show member pathways
12.97 CTSK CXCL8 IFNG IFNGR1 IL1B IL6
9
Show member pathways
12.92 CXCL8 IFNG IL1A IL1B IL6 TNF
10
Show member pathways
12.86 CASP1 CXCL8 IFNG IFNGR1 IL1A IL1B
11
Show member pathways
12.81 CASP1 CXCL8 IFNG IL1B IL6 TNF
12 12.76 CASP1 IL1A IL1B PPP3CA TNF
13
Show member pathways
12.75 BMP2 IL1A IL1B IL6 TNF
14
Show member pathways
12.71 IFNG IFNGR1 IL1A IL1B TNF
15
Show member pathways
12.7 CASP1 IL1A IL1B PPP3CA TNF TNFSF11
16
Show member pathways
12.67 IFNG IFNGR1 IL1A IL1B IL6 PPP3CA
17 12.64 IFNG IL1B IL1RN PPP3CA TNF TNFSF11
18
Show member pathways
12.55 IFNG IL1A IL1B IL6 PPP3CA TNF
19
Show member pathways
12.53 IFNG IFNGR1 PPP3CA TNF
20
Show member pathways
12.45 ACP5 CTSK PPP3CA TNFSF11
21
Show member pathways
12.42 CXCL8 IFNG IL1B IL6 TNF
22
Show member pathways
12.35 CASP1 IL1A IL1B IL1RN
23
Show member pathways
12.34 IFNG IFNGR1 IL1A IL1B TNF
24
Show member pathways
12.3 CXCL8 IFNG IFNGR1 IL1A IL1B IL6
25 12.29 IFNG IFNGR1 IL1A IL1B IL6 PPP3CA
26
Show member pathways
12.28 CXCL8 IFNG IFNGR1 IL1B IL6 TNF
27 12.27 CXCL8 IL1A IL1B IL1RN IL6 TNF
28 12.24 IFNG IFNGR1 IL6 TNF
29
Show member pathways
12.23 CXCL8 IFNG IL1A IL1B IL6 TNF
30 12.16 IFNG IL1A IL1B TNF
31 12.13 BMP2 IL6 LPIN2 TNF
32 12.1 CXCL8 IL1A IL1B IL6 TNF
33
Show member pathways
12.06 IFNG IFNGR1 IL1B IL6 TNF
34 12.03 BMP2 CXCL8 IFNG IL1A IL1B IL6
35 12 CXCL8 IL1A IL1B IL6 TNF
36 11.99 IL1A IL1B IL6 TNF
37 11.99 CXCL8 IFNG IL1B IL6 TNF
38 11.99 CXCL8 IFNG IL1A IL1B IL6 PPP3CA
39 11.98 CXCL8 IL1B TNF TNFSF11
40
Show member pathways
11.97 CASP1 IFNG IFNGR1 IL1B
41
Show member pathways
11.93 IFNG IL1B IL6
42 11.92 IFNG IFNGR1 IL6
43 11.86 IFNG IL1B IL6 TNF
44 11.84 BMP2 IFNG TNF
45 11.83 CXCL8 IFNG IL6
46 11.82 IFNG IL1B TNF
47
Show member pathways
11.8 CXCL8 IFNG TNF
48 11.79 CASP1 CXCL8 IL1A IL1B IL6 TNF
49 11.77 CXCL8 IL1B IL6 TNF
50 11.72 ACP5 CTSK IFNG IFNGR1 IL1A IL1B

GO Terms for Osteomyelitis

Cellular components related to Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP2 CASP1 CTSK CXCL8 IFNG IL1A
2 vesicle GO:0031982 9.46 ANO5 IFNGR1 IL1B IL1RN
3 extracellular space GO:0005615 9.32 BMP2 CTSK CXCL8 IFNG IL1A IL1B

Biological processes related to Osteomyelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.96 BMP2 IFNG PPP3CA TNF
2 response to lipopolysaccharide GO:0032496 9.96 ACP5 CASP1 IL1B IL6
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 CASP1 IL1B TNF TNFSF11
4 positive regulation of protein phosphorylation GO:0001934 9.92 BMP2 IFNG IL1B TNF
5 cytokine-mediated signaling pathway GO:0019221 9.9 IL1A IL1B IL6 TNFSF11
6 defense response to Gram-positive bacterium GO:0050830 9.89 ACP5 IL6 TNF
7 positive regulation of protein kinase B signaling GO:0051897 9.89 IL6 TNF TNFSF11
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TNF TNFSF11
9 positive regulation of neuron differentiation GO:0045666 9.87 BMP2 IFNG IL6
10 cellular response to organic cyclic compound GO:0071407 9.87 BMP2 IL1B TNF
11 positive regulation of JNK cascade GO:0046330 9.86 IL1B TNF TNFSF11
12 response to glucocorticoid GO:0051384 9.86 IL1RN IL6 TNF
13 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
14 neutrophil chemotaxis GO:0030593 9.85 CXCL8 IFNG IL1B
15 positive regulation of T cell proliferation GO:0042102 9.84 IFNG IL1B IL6
16 humoral immune response GO:0006959 9.83 IFNG IL6 TNF
17 calcium-mediated signaling GO:0019722 9.81 CXCL8 PPP3CA TNFSF11
18 inflammatory response GO:0006954 9.8 BMP2 CXCL8 IL1A IL1B IL1RN IL6
19 positive regulation of interleukin-6 production GO:0032755 9.78 IL1A IL1B IL6 TNF
20 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.77 IL1B IL6 PPP3CA TNF TNFSF11
21 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.76 IL1A IL1B TNF
22 cellular response to lipopolysaccharide GO:0071222 9.76 CXCL8 IFNG IL6 TNF
23 positive regulation of cytokine secretion GO:0050715 9.74 CASP1 IL1A TNF
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IFNG IL1B IL6 TNF
25 regulation of osteoclast differentiation GO:0045670 9.72 TNF TNFSF11
26 bone resorption GO:0045453 9.72 ACP5 CTSK TNFSF11
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
28 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG IFNGR1
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
30 positive regulation of osteoclast differentiation GO:0045672 9.71 IFNG TNF TNFSF11
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
32 positive regulation of protein import into nucleus, translocation GO:0033160 9.7 IFNG IL6
33 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
34 positive regulation of gene expression GO:0010628 9.7 BMP2 IFNG IL1A IL1B IL6 PPP3CA
35 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
36 regulation of defense response to virus by host GO:0050691 9.69 IFNG IL1B
37 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG IL1B TNF
38 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.67 IFNG IL1B
39 ectopic germ cell programmed cell death GO:0035234 9.67 IL1A IL1B
40 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IFNG IL1B TNF
41 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
42 positive regulation of NFAT protein import into nucleus GO:0051533 9.65 PPP3CA TNF
43 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.64 IL6 TNF
44 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
45 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
46 interleukin-1 beta production GO:0032611 9.61 CASP1 IL1B
47 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 IL1RN IL6
48 neutrophil apoptotic process GO:0001781 9.58 IFNG IL6
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 IFNG TNF
50 fever generation GO:0001660 9.32 IL1A IL1B

Molecular functions related to Osteomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 BMP2 CXCL8 IFNG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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