MCID: OST003
MIFTS: 58

Osteonecrosis malady

Bone diseases category

Summaries for Osteonecrosis

About this section
Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. in people with healthy bones, new bone is always replacing old bone. in osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. the bone starts to die and may break down. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. at first, you might not have any symptoms. as the disease gets worse, you will probably have joint pain that becomes more severe. you may not be able to bend or move the affected joint very well. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer doctors use imaging tests and other tests to diagnose osteonecrosis. treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteonecrosis, also known as avascular necrosis of bone, is related to osteomyelitis and osteoporosis. An important gene associated with Osteonecrosis is OPN1LW (opsin 1 (cone pigments), long-wave-sensitive), and among its related pathways is Defensins. The compounds hbd2 and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotype limbs/digits/tail.

Disease Ontology:9 An ischemic bone disease that results in necrosis located in bone.

Wikipedia:66 Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and... more...

Aliases & Classifications for Osteonecrosis

About this section
Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
See all sources

Related Diseases for Osteonecrosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis30.5BMP2, ACP5
2osteoporosis30.5BMP2, ACP5, PTH
3osteoarthritis30.2BMP2, ACP5, DEFB4A
4renal osteodystrophy30.1ACP5, PTH
5periodontitis30.1DEFB1, DEFB4A
6periodontal disease29.8DEFB1, DEFB4A
7osteonecrosis of the jaw11.0
8dysbaric osteonecrosis10.7
9endotheliitis10.4
10leukemia10.4
11systemic lupus erythematosus10.4
12lupus erythematosus10.4
13thrombophilia10.4
14arthritis10.3
15myeloma10.3
16multiple myeloma10.3
17lymphoblastic leukemia10.3
18slipped capital femoral epiphysis10.2
19dyskeratosis congenita10.2
20adult acute lymphocytic leukemia10.2
21islet cell tumor10.2
22osteochondrosis10.2
23rheumatoid vasculitis10.2
24breast cancer10.2
25rheumatoid arthritis10.2
26secondary non-traumatic avascular necrosis10.2
27oral candidiasis10.1DEFB4A
28gaucher's disease10.1
29severe acute respiratory syndrome10.1
30septic arthritis10.1
31osteopetrosis10.1
32osteogenesis imperfecta10.1
33disseminated intravascular coagulation10.1
34neuropathy10.1
35hypoxia10.1
36avascular necrosis of the femoral head10.1
37blindness10.1
38candidiasis10.1DEFB4A
39tonsillitis10.1DEFB1, DEFB4A
40duodenal ulcer10.1DEFB1, DEFB4A
41cholesteatoma10.1DEFB4A, DEFB1
42sarcoidosis10.0DEFB1, DEFB4A
43gastritis10.0DEFB1, DEFB4A
44pigmented villonodular synovitis10.0
45kummell's disease10.0
46protein s deficiency10.0
47hyperhomocysteinemia10.0
48villonodular synovitis10.0
49herpes zoster10.0
50osteochondritis dissecans10.0

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to osteonecrosis

Symptoms for Osteonecrosis

About this section

Drugs & Therapeutics for Osteonecrosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
See all sources

Approved drugs:

Search CenterWatch for Osteonecrosis

Drug clinical trials:

Search ClinicalTrials for Osteonecrosis

Search NIH Clinical Center for Osteonecrosis

Search CenterWatch for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677

Genetic Tests for Osteonecrosis

About this section

Anatomical Context for Osteonecrosis

About this section
Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Osteonecrosis:

34
Bone, Testes, Skin, Endothelial, Bone marrow, Breast, Kidney, Liver, Prostate, T cells, Adipocyte, Lung

FMA organs/tissues related to Osteonecrosis:

15
Bone

Animal Models for Osteonecrosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Osteonecrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.1BMP2, ACP5, MSX1, PTH

Publications for Osteonecrosis

About this section
Sources:
53PubMed
See all sources

Articles related to Osteonecrosis:

(show top 50)    (show all 690)
idTitleAuthorsYear
1
Mandibulectomy and free flap reconstruction for bisphosphonate-related osteonecrosis of the jaws. (24051498)
2013
2
An unusual complication in osteonecrosis of femoral head: a case report. (23401822)
2013
3
Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis. (23696921)
2013
4
Interleukin-6 concentration changes in plasma and saliva in bisphosphonate-related osteonecrosis of the jaws. (23837828)
2013
5
Arthroscopically assisted fibular strut allograft for treatment of osteonecrosis of proximal humerus. (24393185)
2013
6
Association between PAI-1 4G/5G Polymorphisms and osteonecrosis of femoral head: a meta-analysis. (23856555)
2013
7
Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate. (23941019)
2013
8
Osteonecrosis of the jaw in a patient with rheumatoid artritis treated with an oral aminobisphosphonate: a clinical case report. (24133533)
2013
9
Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw: reply to Subramanian and Quek. (22581291)
2013
10
Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. (23645686)
2013
11
There are many potential medical therapies for atraumatic osteonecrosis. (23041599)
2013
12
Total hip arthroplasty in steroid-induced osteonecrosis: early functional and radiological outcomes. (22992403)
2013
13
Combination of zoledronic Acid and targeted therapy is active but may induce osteonecrosis of the jaw in patients with metastatic renal cell carcinoma. (23642545)
2013
14
C-terminal cross-linking telopeptide as a serologic marker for bisphosphonate-related osteonecrosis of the jaw: review of 2 cases. (23920073)
2013
15
Laser does not cause osteonecrosis when properly used. (23317452)
2013
16
FDG-PET may predict the effectiveness of hyperbaric oxygen therapy in a patient with bisphosphonate-related osteonecrosis of the jaw: report of a case. (23907202)
2013
17
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
18
Nontraumatic osteonecrosis of the femoral head: endoscopic visualization of its avascular burden. (22955395)
2012
19
Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids: a multicenter case-control study in Japan. (22927108)
2012
20
Predictive role of cytokine gene polymorphisms for the development of femoral head osteonecrosis. (22975999)
2012
21
Early results of a novel technique using multiple small tantalum pegs for the treatment of osteonecrosis of the femoral head: a case series involving 26 hips. (22323681)
2012
22
CORR insights: Reliability of Bucholz and Ogden classification for osteonecrosis secondary to developmental dysplasia of the hip. (22903284)
2012
23
Bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. (22962894)
2012
24
Mandibular bisphosphonate-related osteonecrosis after dental implant rehabilitation: a case report. (23075811)
2012
25
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 17. Osteonecrosis. (22852516)
2012
26
Can local Erythropoietin administration enhance bone regeneration in osteonecrosis of femoral head? (22617757)
2012
27
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
28
Radiographic signs of bisphosphonate-related osteonecrosis of the jaw. (23311051)
2012
29
The effects of autologous bone marrow mesenchymal stem cell arterial perfusion on vascular repair and angiogenesis in osteonecrosis of the femoral head in dogs. (23064553)
2012
30
Vascular endothelial growth factor -634G/C polymorphism associated with osteonecrosis of the femoral head in a Chinese population. (22612467)
2012
31
Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. (22340480)
2012
32
Physiology and pharmacology of nonbisphosphonate drugs implicated in osteonecrosis of the jaw. (22985897)
2012
33
Association of osteonecrosis and peripheral neuropathy in HIV-1-infected patients: possible roles of nerve growth factor and vascular endothelial growth factor. (22067199)
2011
34
Vascular endothelial growth factor genetic polymorphisms and haplotypes in female patients with bisphosphonate-related osteonecrosis of the jaws. (21251073)
2011
35
A current update on osteonecrosis of the jaw and bisphosphonates. (22408887)
2011
36
Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. (21752301)
2011
37
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
38
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. (20929185)
2010
39
Different differentiation of stroma cells from patients with osteonecrosis: a pilot study. (19330390)
2009
40
Coagulopathies frequency in aseptic osteonecrosis patients. (19211287)
2009
41
Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. (19345290)
2009
42
Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. (22752739)
2009
43
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis. (18719618)
2008
44
Peroxisome proliferator-activated receptor-gamma gene polymorphisms are not associated with osteonecrosis of the femoral head in the Korean population. (18182855)
2007
45
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (15784727)
2005
46
Hyperbaric oxygen therapy for idiopathic osteonecrosis of the femoral head in adults: Executive summary of final report N06-01D, Version 1.0 (23101065)
2005
47
Type II collagen gene variants and inherited osteonecrosis of the femoral head. (15930420)
2005
48
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
49
Radiology rounds. KienbAPck's disease (osteonecrosis of the lunate). (9721413)
1998
50
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. (2396333)
1990

Variations for Osteonecrosis

About this section

Expression for genes affiliated with Osteonecrosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for genes affiliated with Osteonecrosis

About this section
Sources:
51PathCards, 56Reactome
See all sources

Pathways related to Osteonecrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DEFB1, DEFB4A

Compounds for genes affiliated with Osteonecrosis

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience
See all sources

Compounds related to Osteonecrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1hbd24610.1DEFB1, DEFB4A
2ticlopidine46 1211.0APOH, CYP2C8
3cerivastatin52 46 30 1212.9BMP2, CYP2C8
4lipoteichoic acid469.9DEFB4A, APOH
5raloxifene46 52 30 1212.9CYP2C8, BMP2
6warfarin46 52 25 1212.8APOH, CYP2C8
7diethylstilbestrol46 30 1211.8ACP5, CYP2C8
8fluvastatin46 52 30 1212.8BMP2, CYP2C8
9pamidronate46 52 1211.7PTH, CYP2C8
10titanium469.7BMP2, ACP5
11deoxyribonucleic acid469.7BMP2, APOH
12pravastatin46 52 30 25 1213.6BMP2, CYP2C8
13cyclophosphamide46 52 1211.5CYP2C8, APOH, BMP2
14alendronate46 52 1211.5BMP2, PTH
15hydroxyapatite469.4BMP2, ACP5
16rantes469.4ACP5, DEFB1, DEFB4A
17deoxypyridinoline469.4PTH, ACP5
1825-hydroxyvitamin d469.3PTH, ACP5
19ethanol46 52 25 1212.3ACP5, APOH, CYP2C8
20androstenedione46 2510.3PTH, CYP2C8
21hydroxyproline46 25 1211.3ACP5, PTH
22tetracycline46 1210.2ACP5, BMP2
23azathioprine46 3 52 1212.2BMP2, ACP5, APOH
24polyacrylamide469.2BMP2, ACP5, APOH
25steroid469.1DEFB4A, APOH, PROK1, BMP2
26polyethylene glycol469.0BMP2, ACP5
27phosphorus468.9PTH, APOH, ACP5
28procollagen468.9BMP2, ACP5, PTH
291,25 dihydroxy vitamin d3468.9PTH, ACP5, BMP2
30calcitriol46 62 25 1211.9BMP2, ACP5, PTH
31vitamin d468.8PTH, ACP5, BMP2
32heparin46 30 25 1211.8BMP2, ACP5, APOH, DEFB4A
33progesterone46 30 62 25 1212.8DEFB4A, CYP2C8, APOH, PROK1, BMP2
34retinoic acid46 259.8DEFB4A, DEFB1, CYP2C8, MSX1, BMP2
35oxygen46 259.8BMP2, ACP5, APOH, CYP2C8
36estradiol46 25 1210.7DEFB4A, CYP2C8, PTH, ACP5
37pge2468.7PTH, ACP5, BMP2
38vegf468.7PTH, APOH, PROK1, BMP2
39glucose468.5BMP2, APOH, PTH, DEFB1
40lipid468.5DEFB4A, APOH, ACP5, BMP2
41creatinine468.4PTH, APOH, ACP5, BMP2
42nitric oxide46 25 1210.4PTH, APOH, ACP5, BMP2
43tyrosine468.1DEFB4A, CYP2C8, PTH, ACP5, BMP2
44estrogen468.0BMP2, ACP5, APOH, PTH, DEFB4A
45dexamethasone46 52 30 1210.8BMP2, ACP5, PTH, CYP2C8, DEFB1, DEFB4A
46calcium46 52 25 1210.4DEFB4A, PTH, APOH, PROK1, ACP5, BMP2

GO Terms for genes affiliated with Osteonecrosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Osteonecrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7DEFB1, DEFB4A
2extracellular regionGO:0055767.7BMP2, PROK1, PTH, DEFB1, DEFB4A

Biological processes related to Osteonecrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone morphogenesisGO:0603499.5ACP5, MSX1
2odontogenesis of dentin-containing toothGO:0424759.4BMP2, MSX1
3activation of MAPK activityGO:0001879.3BMP2, PROK1
4positive regulation of bone mineralizationGO:0305019.2BMP2, PTH
5bone resorptionGO:0454539.2ACP5, PTH
6G-protein coupled receptor signaling pathwayGO:0071868.9DEFB4A, DEFB1, PTH
7negative regulation of transcription from RNA polymerase II promoterGO:0001228.7BMP2, MSX1, PTH

Products for genes affiliated with Osteonecrosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteonecrosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet