MCID: OST003
MIFTS: 49

Osteonecrosis malady

Bone category

Summaries for Osteonecrosis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. in people with healthy bones, new bone is always replacing old bone. in osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. the bone starts to die and may break down. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. at first, you might not have any symptoms. as the disease gets worse, you will probably have joint pain that becomes more severe. you may not be able to bend or move the affected joint very well. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer doctors use imaging tests and other tests to diagnose osteonecrosis. treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteonecrosis, also known as avascular necrosis of bone, is related to osteoporosis and renal osteodystrophy. An important gene associated with Osteonecrosis is OPN1LW (opsin 1 (cone pigments), long-wave-sensitive), and among its related pathways is Beta defensins. The compounds hbd2 and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and liver.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in bone.

Wikipedia:64 Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and... more...

Aliases & Classifications for Osteonecrosis

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Osteonecrosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.6ALPPL2, ACP5, DKK1
2renal osteodystrophy30.1ALPPL2, ACP5
3sinusitis30.0DEFB4A
4dysbaric osteonecrosis10.7
5systemic lupus erythematosus10.4
6thrombophilia10.4
7arthritis10.3
8acute leukemia10.3
9slipped capital femoral epiphysis10.2
10dyskeratosis congenita10.2
11n syndrome10.2
12adult acute lymphocytic leukemia10.2
13carcinoid syndrome10.2
14rheumatoid vasculitis10.2
15myxedema10.2
16osteoarthritis10.2
17severe acute respiratory syndrome10.1
18osteopetrosis10.1
19septic arthritis10.1
20osteogenesis imperfecta10.1
21hypoxia10.1
22acetabular dysplasia10.1
23pigmented villonodular synovitis10.0
24gaucher's disease10.0
25villonodular synovitis10.0
26hyperhomocysteinemia10.0
27herpes zoster10.0
28osteochondritis dissecans10.0
29protein c deficiency10.0
30synovitis10.0
31vascular disease10.0
32sickle cell disease10.0
33acute lymphoblastic leukemia, childhood10.0
34meningococcemia10.0
35protein r deficiency10.0
36head injury10.0
37osteoporosis, postmenopausal10.0
38oral candidiasis10.0DEFB4A
39candidiasis10.0DEFB4A
40tonsillitis10.0DEFB4A, DEFB1
41paget's disease of bone10.0ALPPL2
42periodontal disease10.0DEFB1, DEFB103B, DEFB4A
43sarcoidosis10.0DEFB4A, DEFB1
44myeloma10.0DKK1, ACP5, ALPPL2
45cholesteatoma10.0DEFB4A, DEFB1
46inflammatory bowel disease10.0ALPPL2
47multiple myeloma10.0DKK1
48choriocarcinoma10.0ALPPL2
49ecthyma9.9
50meningococcal infection9.9

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to osteonecrosis

Clinical Features for Osteonecrosis

Drugs & Therapeutics for Osteonecrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Osteonecrosis

Drug clinical trials:

Search ClinicalTrials for Osteonecrosis

Search NIH Clinical Center for Osteonecrosis

Search CenterWatch for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677

Genetic Tests for Osteonecrosis

Anatomical Context for Osteonecrosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Osteonecrosis:

33
Skin, Liver, Kidney, Lung, Bone marrow, Whole blood, Adipocyte, Breast, Prostate, T cells, Endothelial

FMA organs/tissues related to Osteonecrosis:

14
Bone

Animal Models for Osteonecrosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Osteonecrosis

Sources:
51PubMed
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Articles related to Osteonecrosis:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
FDG-PET may predict the effectiveness of hyperbaric oxygen therapy in a patient with bisphosphonate-related osteonecrosis of the jaw: report of a case. (23907202)
2013
2
Elevated level of membrane microparticles in the disease of steroid-induced vascular osteonecrosis. (23851782)
2013
3
Posttraumatic osteonecrosis and nonunion of distal pole of scaphoid. (23960291)
2013
4
Attrition tendinitis of long head of biceps brachii in relation to humeral head osteonecrosis: case report. (24063803)
2013
5
Weekly teriparatide injections successfully treated advanced bisphosphonate-related osteonecrosis of the jaws. (23371327)
2013
6
Vascularized periosteal graft from the first metatarsal bone: a new technique to prevent collapse of osteonecrosis of the talus in children. A case report. (22976600)
2013
7
Evaluation of an algorithm ascertaining cases of osteonecrosis of the jaw in the Swedish National Patient Register. (23323023)
2013
8
Osteonecrosis of the femoral head in SARS patients: seven years later. (23412187)
2013
9
Finite element analysis of the multiple drilling technique for early osteonecrosis of the femoral head. (23793386)
2013
10
Atypical femoral fractures shortly after osteonecrosis of the jaw in a postmenopausal woman taking alendronate for osteoporosis. (23471975)
2013
11
Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures. (22618266)
2013
12
Metastatic cancer identified in osteonecrosis specimens of the jaws in patients receiving intravenous bisphosphonate medications. (23945512)
2013
13
Osteonecrosis of the knee after arthroscopic partial meniscectomy. (24032105)
2013
14
An evidence-based review of risk-reductive strategies for osteonecrosis of the jaws among cancer patients. (23092218)
2013
15
Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review. (23964780)
2013
16
Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population. (24135164)
2013
17
Endothelial nitric oxide synthase gene intron 4 polymorphism in non-traumatic osteonecrosis of the femoral head. (23604198)
2013
18
Nontraumatic osteonecrosis of the femoral head: endoscopic visualization of its avascular burden. (22955395)
2012
19
Mandibular bisphosphonate-related osteonecrosis after dental implant rehabilitation: a case report. (23075811)
2012
20
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 17. Osteonecrosis. (22852516)
2012
21
Drug-related osteonecrosis of the jaws: "Exposure, or not exposure: that is the question". (22668630)
2012
22
Treatment of femoral head osteonecrosis with advanced cell therapy in sheep. (22821379)
2012
23
Platelet-rich plasma as a nonsurgical treatment option for osteonecrosis. (23245664)
2012
24
Sixty cases of extreme osteonecrosis and osteomyelitis of the mandible and maxilla in a West African population. (22652445)
2012
25
Association between MTHFR C677T polymorphism and osteonecrosis of the femoral head: a meta-analysis. (22311035)
2012
26
Development of a clinically relevant animal model for the talar osteonecrosis in sheep. (23136546)
2012
27
Femoral head osteonecrosis after long-term topical corticosteroid treatment in a psoriasis patient. (22300106)
2012
28
Risks for jaw osteonecrosis drastically increases after 2 years of bisphosphonate therapy. (23253854)
2012
29
Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect? (22770117)
2012
30
Comment on Compston: pathophysiology of atypical femoral fractures and osteonecrosis of the jaw. (22290240)
2012
31
Long-term results of conventional varus half-wedge proximal femoral osteotomy for the treatment of osteonecrosis of the femoral head. (22371535)
2012
32
Osteonecrosis of jaw with the use of denosumab. (22269422)
2011
33
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
34
The unstable slipped capital femoral epiphysis: risk factors for osteonecrosis. (20733417)
2010
35
T-786C polymorphism of the endothelial nitric oxide synthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws. (20185342)
2010
36
Atraumatic osteonecrosis after estrogen replacement therapy associated with low protein S level in a patient with Turner syndrome. (19648147)
2010
37
Paget's disease of bone and osteonecrosis. (19480105)
2009
38
Dysbaric osteonecrosis in experienced dive masters and instructors. (18064920)
2007
39
From marrow oedema to osteonecrosis: common paths in the development of post-transplant bone pain. (17199798)
2006
40
Hyperbaric oxygen therapy for idiopathic osteonecrosis of the femoral head in adults: Executive summary of final report N06-01D, Version 1.0 (23101065)
2005
41
Detection of dysbaric osteonecrosis in military divers using magnetic resonance imaging. (15490180)
2005
42
Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects. (14742985)
2004
43
A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. (14768474)
2003
44
Hypofibrinolysis, thrombophilia, osteonecrosis. (11347834)
2001
45
Thrombophilia, hypofibrinolysis, and alveolar osteonecrosis of the jaws. (8734702)
1996
46
The pathophysiology of alveolar osteonecrosis of the jaw: anticardiolipin antibodies, thrombophilia, and hypofibrinolysis. (8621985)
1996
47
Neuralgia-inducing cavitational osteonecrosis (NICO). Osteomyelitis in 224 jawbone samples from patients with facial neuralgia. (1545963)
1992
48
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. (2396333)
1990
49
Use of ultrasonography in the diagnosis of dysbaric osteonecrosis. (2288044)
1990
50
Epiphyseal sclerosis in renal osteodystrophy simulating osteonecrosis. (6786046)
1981

Genetic Variations for Osteonecrosis

Expression for genes affiliated with Osteonecrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for genes affiliated with Osteonecrosis

Sources:
54Reactome
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Pathways related to Osteonecrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4DEFB4A, DEFB103B, DEFB1

Compounds for genes affiliated with Osteonecrosis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
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Compounds related to Osteonecrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hbd24510.5DEFB1, DEFB103B, DEFB4A
2ticlopidine45 1111.5CYP2C8, APOH
3progesterone45 60 29 11 2414.4APOH, PROK1, DEFB103B, DEFB4A, DKK1, CYP2C8
4ethanol45 50 11 2413.3APOH, CYP2C8, ACP5, ALPPL2
5dexamethasone45 50 29 1113.1DEFB103B, DEFB1, DEFB4A, CYP2C8, ACP5

GO Terms for genes affiliated with Osteonecrosis

Sources:
16Gene Ontology
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Molecular functions related to Osteonecrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:00449710.4CYP27C1, CYP2C8

Products for genes affiliated with Osteonecrosis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Osteonecrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet