Osteonecrosis malady

MedlinePlus: Osteonecrosis occurs when your bones lose their blood supply. the bones die and eventually collapse, leading to pain and arthritis. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. early in the disease you might not have any symptoms. later, you will probably have joint pain that becomes more severe as the disease gets worse. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Osteonecrosis, also known as bone necrosis, is related to avascular necrosis of femoral head and legg-calve-perthes disease. An important gene associated with Osteonecrosis is CBY3 (chibby homolog 3 (Drosophila)), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Extrinsic Prothrombin Activation Pathway. The compounds cyclophosphamide and steroid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Disease Ontology: An ischemic bone disease that results in necrosis located in bone.⁶

Wikipedia: Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and...⁴⁴ more...

Aliases & Descriptions:

osteonecrosis 6 8 23 bone necrosis 6 43 avascular necrosis of bone 6

aseptic necrosis of bone 43 avascular necrosis 43

Diseases related to osteonecrosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 750)

id	Related Disease	Score	Top Affiliating Genes
1	avascular necrosis of femoral head	33.8	VEGFA, BMP2, APOA1, APOB, CAT, COL2A1
2	legg-calve-perthes disease	31.7	SERPINC1, SERPINE1, F5, COL2A1
3	thrombophilia	29.6	VWF, SERPINC1, SERPINE1, MTHFR, APOB, APOH
4	systemic lupus erythematosus	29.3	VWF, IL17A, APOH, ANXA5, ANXA11, ANXA2
5	antithrombin iii deficiency	28.4	SERPINC1, MTHFR, APOH, F5, F2, PLG
6	gaucher's disease	28.3	VDR, BMP4, BGLAP, MTHFR, CD36, F5
7	acute lymphoblastic leukemia	28.2	COG2, SERPINC1, MTHFR, APOB, ANXA5, CYP3A4
8	antiphospholipid syndrome	27.6	VWF, SERPINC1, SERPINE1, VEGFA, MTHFR, APOB
9	severe acute respiratory syndrome	26.6	VWF, SERPINC1, ANXA5, ANXA2, F5, F3
10	protein s deficiency	26.4	SERPINC1, SERPINE1, MTHFR, APOA1, APOB, APOH
11	hyperhomocysteinemia	25.8	VWF, SERPINC1, SERPINE1, MTHFR, APOA1, APOB
12	sickle cell disease	24.0	KL, VWF, SERPINE1, VEGFA, BMP4, BMP6
13	osteoporosis	21.8	LRP5, KL, SERPINC1, VEGFA, VDR, BMP2
14	lymphoblastic leukemia	19.5	LRP5, COG2, VWF, SERPINC1, SERPINE1, VEGFA
15	multiple myeloma	18.7	VWF, SERPINC1, VEGFA, BMP2, BMP4, BMP6
16	lupus erythematosus	18.6	COG2, VWF, SERPINC1, SERPINE1, VEGFA, VDR
17	osteoarthritis	17.9	LRP5, KL, SERPINE1, VEGFA, VDR, BMP2
18	myeloma	17.4	LRP5, VWF, SERPINC1, VEGFA, VDR, BMP2
19	ischemia	17.2	COG2, VWF, SERPINC1, SERPINE1, VEGFA, VEGFC
20	hypoxia	16.7	LRP5, NCOA2, VWF, SERPINE1, VEGFA, VEGFC
21	cerebritis	15.9	COG2, VWF, SERPINC1, SERPINE1, VEGFA, BMP6
22	leukemia	15.7	LRP5, COG2, NCOA2, VWF, SERPINC1, SERPINE1
23	pancreatitis	15.2	LRP5, KL, VWF, SERPINC1, SERPINE1, VEGFA
24	metaphyseal dysplasia	13.9	PTH, PTH1R, COL2A1, ACP5
25	placental infarction	13.9	SERPINC1, APOH, F5
26	common bile duct disease	13.9	ALPL, ALPP, ALPPL2
27	placental abruption	13.8	SERPINC1, MTHFR, F5
28	amaurosis fugax	13.8	SERPINE1, MTHFR, APOH, F5
29	blood protein disease	13.8	MTHFR, F5, F2
30	osteochondrodysplasia	13.8	BGLAP, ALPL, PTH1R, COMP, COL2A1
31	pseudohypoparathyroidism type ib	13.8	BGLAP, PTH, PTH1R
32	neonatal stroke	13.8	SERPINE1, MTHFR, F5
33	sagittal sinus thrombosis	13.8	SERPINC1, F5, F3
34	porencephaly	13.8	MTHFR, F5, F2
35	camurati-engelmann disease	13.8	LRP5, BGLAP, ACP5, TGIF1
36	synostosis	13.8	BMP2, BMP4, MSX1, ISYNA1
37	hepatic vein thrombosis	13.8	SERPINE1, MTHFR, F5
38	prothrombin deficiency	13.8	SERPINC1, APOH, F5, F2
39	factor xii deficiency	13.8	F5, F3, F2
40	thrombosis	13.8	MTHFR, F5, F2
41	schizencephaly	13.7	BGLAP, MTHFR, F5
42	sneddon syndrome	13.7	SERPINC1, APOH, F5, F2
43	factor x deficiency	13.7	F5, F3, F2
44	catastrophic antiphospholipid syndrome	13.7	SERPINE1, MTHFR, APOH, F5, F3
45	intracranial hypertension	13.7	SERPINC1, SERPINE1, APOH, F5
46	factor v deficiency	13.7	F5, F3, F2
47	vein disease	13.7	SERPINC1, MTHFR, F5, F2
48	vitamin d-dependent rickets type ii	13.7	VDR, BGLAP, PTH
49	spinal cord infarction	13.7	SERPINC1, MTHFR, APOH, F5, F2
50	intracranial thrombosis	13.7	SERPINC1, F5, F2, PLG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to osteonecrosis:

²²

FMA organs/tissues related to osteonecrosis:

¹¹

MGI Mouse Phenotypes related to osteonecrosis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	RUNX2, PTH, MSX1, NCOA2, KL, LRP5
2	hematopoietic system phenotype	MP:0005397	10.0	RUNX2, PTH, TNFSF11, ALPL, IL23R, IL17A
3	respiratory system phenotype	MP:0005388	10.0	RUNX2, COL2A1, PTH1R, CALCA, ALPL, MSX1
4	craniofacial phenotype	MP:0005382	9.8	RUNX2, DKK1, TFPI, TGIF1, COL2A1, NRP1
5	embryogenesis phenotype	MP:0005380	9.7	DKK1, TFPI, TFAP2A, COL2A1, CREBBP, CYR61
6	reproductive system phenotype	MP:0005389	9.1	PLG, TNFSF11, ALPP, ALPL, MSX1, BMP7
7	renal/urinary system phenotype	MP:0005367	8.7	NOS3, COL2A1, HIF1A, DKK1, PLG, ESR1
8	hearing/vestibular/ear phenotype	MP:0005377	8.5	CTGF, PPARG, COL2A1, ABCB1, TFAP2A, TNFRSF11B
9	integument phenotype	MP:0010771	8.4	TNFSF11, NR3C1, CREBBP, TFAP2A, TFPI, RUNX2
10	nervous system phenotype	MP:0003631	7.8	CREBBP, NRP1, NR3C1, ALPL, PLG, COL2A1
11	limbs/digits/tail phenotype	MP:0005371	7.7	RUNX2, BMP2, VDR, VEGFA, KL, LRP5
12	liver/biliary system phenotype	MP:0005370	7.7	SREBF1, PLG, NOS3, COL2A1, ABCB1, HIF1A
13	behavior/neurological phenotype	MP:0005386	7.2	PPARG, NR3C1, CREBBP, NOS3, COMP, COL2A1
14	immune system phenotype	MP:0005387	7.2	RUNX2, IL23R, CHST2, KDR, PAG1, VDR
15	adipose tissue phenotype	MP:0005375	6.7	NOS3, CREBBP, NR3C1, PPARG, TP53, ESR1
16	vision/eye phenotype	MP:0005391	6.6	PPARG, NRP1, PLG, NOS3, COL2A1, HIF1A
17	normal phenotype	MP:0002873	6.5	TP53, CTGF, PPARG, NR3C1, CREBBP, COMP
18	digestive/alimentary phenotype	MP:0005381	6.0	TP53, PTH1R, CTGF, NR3C1, CREBBP, PLG
19	growth/size phenotype	MP:0005378	6.0	TNFSF11, TNFRSF11B, TP53, ALPP, ALPL, HTR3A
20	muscle phenotype	MP:0005369	5.7	ESR1, TP53, PPARG, CREBBP, NOS3, COMP
21	skeleton phenotype	MP:0005390	5.1	TNFSF11, TNFRSF11B, TP53, ESR1, CALCA, ALPL
22	mortality/aging	MP:0010768	3.5	RUNX2, DEFB1, DKK1, TFPI, TFAP2A, TF
23	cellular phenotype	MP:0005384	3.1	NRP1, NR3C1, PPARG, CTGF, CYR61, TNFSF11
24	cardiovascular system phenotype	MP:0005385	2.6	RUNX2, PON1, TFPI, TFAP2A, TGIF1, HIF1A
25	homeostasis/metabolism phenotype	MP:0005376	1.3	ANXA2, VWF, KL, LRP5, SERPINC1, SERPINE1

Articles related to osteonecrosis:

(show top 50)    (show all 90)

id	Title	Authors	Year	Affiliating Genes
1	Vascular endothelial growth factor polymorphisms in p atients with steroid-induced femoral head osteonecrosis. (21710604)	Lee Y.J.... Koo K.H.	2012	VEGFA
2	Increased human defensine levels hint at an inflammat ory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohi stological study. (21843332)	Stockmann P.... Nkenke E.	2011	DEFB1, DEFB4A, DEFB103B
3	Vascular endothelial growth factor genetic polymorphi sms and haplotypes in female patients with bisphosphonate-related osteonecrosis of the jaws. (21251073)	Arduino P.G.... Broccoletti R.	2011	VEGFA
4	Study on the relationship between sclerosis rim and bone morphogenetic proteins of osteonecrosis of the femoral head]. (21092609)	Shi S.H.... Wang R.D.	2010	BMP4
5	T-786C polymorphism of the endothelial nitric oxide s ynthase gene and neuralgia-inducing cavitational osteonecrosis of the jaws. (20185342)	Glueck C.J.... Wang P.	2010	NOS3
6	Osteonecrosis in patients after severe acute respirat ory syndrome (SARS): possible role of anticardiolipin antibodies. (20216125)	Sun W.... Li Z.R.	2010	APOH
7	Expression of Msx-1 is suppressed in bisphosphonate a ssociated osteonecrosis related jaw tissue-etiopathology considerations respect ing jaw developmental biology-related unique features. (20942943)	Wehrhan F.... Amann K.	2010	MSX1
8	Genetic Association of Angiogenesis- and Hypoxia-Rela ted Gene Polymorphisms with Osteonecrosis of the Femoral Head. (20215856)	Hong J.M.... Kim S.Y.	2010	KDR, TF, ACE
9	Coagulopathies frequency in aseptic osteonecrosis patients. (19211287)	Mehsen N.... Schaeverbeke T.	2009	F2, F5, MTHFR
10	Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans. (19040658)	Lee H.J.... Kim U.K.	2009	SREBF1
11	Differential expression of vascular endothelial growt h factor in glucocorticoid-related osteonecrosis of the femoral head. (19763724)	Varoga D.... Pufe T.	2009	VEGFA
12	Incidence of genetic polymorphisms involved in lipid metabolism among Chinese patients with osteonecrosis of the femoral head. (19626470)	He W.... Li K.	2009	CYP3A4, ABCB1
13	Factors associated with osteonecrosis in Thai lupus p atients: a case control study. (20009970)	Uea-areewongsa P.... Asavatanabodee P.	2009	APOH
14	Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. (18350352)	Chang J.D.... Lee K.M.	2008	F2, F5, MTHFR
15	Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis. (18594024)	Sarasquete M.E.... San Miguel J.F.	2008	CYP2C8
16	Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis. (18979157)	Okuma C.... Tanaka S.	2008	TP53
17	Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis. (18719618)	Muller I.... Rudert M.	2008	PROK1
18	Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population. (17698375)	Kim T.H.... Kim S.Y.	2008	VEGFA
19	Impaired dexamethasone-related increase of anticoagul ants is associated with the development of osteonecrosis in childhood acute lym phoblastic leukemia. (18698082)	e Winkel M.L.... van den Heuvel-Eibrink M.M.	2008	SERPINC1
20	Genetic association study of polymorphisms in the catalase gene with the risk of osteonecrosis of the femoral head in the Korean population. (18353692)	Kim T.H.... Kim S.Y.	2008	CAT
21	Association Analysis of Tissue Factor Pathway Inhibitor Polymorphisms and Haplotypes with Osteonecrosis of the Femoral Head in the Korean Population. (18695356)	Dai X.L.... Kim S.Y.	2008	TFPI
22	A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. (18285546)	French D.... Relling M.V.	2008	TYMS, VDR, SERPINE1
23	Reduced serum levels of Interleukin 17 in patients with osteonecrosis of the jaw and in multiple myeloma subjects after bisphosphonates administration. (18585926)	Oteri G.... Musolino C.	2008	IL17A
24	MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. (18214345)	Yang X.Y.... Xu D.H.	2007	ABCB1
25	Genetic analysis for prevention of steroid-induced osteonecrosis of the femoral head (17548929)	Fujioka M.... Nakajima S.	2007	CREBBP, ABCB1, APOB
26	Hepatic CYP3A activity in association with developme nt of osteonecrosis of the femoral head (17548930)	Kaneshiro Y.... Takaoka K.	2007	CYP3A4
27	Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions. (17469180)	Hadjigeorgiou G.M.... Karantanas A.	2007	PON1
28	Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population. (17292638)	Hong J.M.... Kim S.Y.	2007	HIF1A
29	Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. (16547717)	Sun W.... Zhang Y.C.	2006	PLG, SERPINC1, F5
30	Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis. (16779830)	Koo K.H.... Kim H.J.	2006	NOS3
31	From marrow oedema to osteonecrosis: common paths in the development of post-transplant bone pain. (17199798)	Elder G.J.	2006	CABIN1
32	Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis (16677567)	Sun W.... Zhang Y.C.	2006	VWF, F2, PLG
33	Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (15784727)	Baldwin C.... Steinberg M.H.	2005	KL, ANXA2, BMP6
34	Type II collagen gene variants and inherited osteonecrosis of the femoral head. (15930420)	Liu Y.-F.... Tsai S.-F.	2005	COL2A1
35	Spontaneous osteonecrosis of the knee: biochemical markers of bone turnover and pathohistology. (15922633)	Berger C.E.... Engel A.	2005	CD36, ALPP
36	Joint biomarkers in idiopathic femoral head osteonecrosis: comparison with hip osteoarthritis. (16078329)	Kato S.... Henmi O.	2005	COMP
37	Factor V leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults. (15292803)	Bjorkman A.... Benoni G.	2004	F2, F5
38	Genetic background of osteonecrosis: associated with thrombophilic mutations? (15187864)	Zalavras C.G.... Malizos K.N.	2004	F2, F5
39	Osteonecrosis in patients with testicular tumours tre ated with chemotherapy. (15061230)	van den Berkmortel F.... DeMulder P.	2004	HTR3A
40	Osteonecrosis in HIV-infected patients (15338975)	Bottaro E.G.... Cassetti I.	2004	APOH
41	A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. (14768474)	Sakata R.	2003	ALDH2, ADH1B
42	Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis. (14677097)	Bernbeck B.... Gobel U.	2003	MTHFR
43	Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients. (12438962)	Ferrari P.... Kohler H.P.	2002	SERPINE1
44	The 677C-->T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. (11801474)	Zalavras C.G.... Vartholomatos G.	2002	MTHFR
45	Hypofibrinolysis, thrombophilia, osteonecrosis. (11347834)	Glueck C.J.... Wang P.	2001	SERPINE1
46	Idiopathic osteonecrosis in an adult with familial protein S deficiency and hyperhomocysteinemia. (11685042)	Elishkewich K.... Berliner S.	2001	MTHFR
47	Antithrombin III deficiency in a patient with multifocal osteonecrosis. (10987006)	Kubo T.... Hirasawa Y.	2000	SERPINC1
48	Coagulopathies and osteonecrosis. (10084210)	Jones J.P.	1999	SERPINC1, F5
49	Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. (9917651)	Mont M.A.... Reddi A.H.	1998	TGIF1
50	The pathophysiology of alveolar osteonecrosis of the jaw: anticardiolipin antibodies, thrombophilia, and hypofibrinolysis. (8621985)	Gruppo R.... Wang P.	1996	APOH

Genes related to osteonecrosis according to GeneCards:

(show top 50)    (show all 89)

id	Symbol	Description	Score	GeneCards Section Context
1	CBY3	chibby homolog 3 (Drosophila)	11.0	Disorders
2	PRR20A	proline rich 20A	11.0
3	DEFB103B	defensin, beta 103B	11.0	Publications
4	OPN1LW	opsin 1 (cone pigments), long-wave-sensitive	11.0	Publications
5	PROK1	prokineticin 1	11.0	Publications
6	CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	11.0
7	CHST2	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	11.0
8	ISYNA1	inositol-3-phosphate synthase 1	11.0
9	ZNF461	zinc finger protein 461	11.0	Disorders
10	CYP27C1	cytochrome P450, family 27, subfamily C, polypeptide 1	11.0	Disorders
11	DKK1	dickkopf 1 homolog (Xenopus laevis)	11.0	Publications
12	MSX1	msh homeobox 1	11.0	Publications
13	ACP5	acid phosphatase 5, tartrate resistant	11.0	Publications
14	DEFB1	defensin, beta 1	11.0	Publications
15	CYR61	cysteine-rich, angiogenic inducer, 61	11.0	Publications
16	COMP	cartilage oligomeric matrix protein	11.0	Publications
17	COL2A1	collagen, type II, alpha 1	11.0	Publications
18	ZNF28	zinc finger protein 28	11.0	Disorders
19	ALPPL2	alkaline phosphatase, placental-like 2	11.0
20	ZNF71	zinc finger protein 71	11.0
21	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
22	SREBF1	sterol regulatory element binding transcription factor 1	11.0	Publications
23	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
24	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	11.0	Publications
25	PTH1R	parathyroid hormone 1 receptor	11.0	Publications
26	CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	11.0	Publications
27	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
28	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	11.0	Publications
29	KL	klotho	11.0	Publications
30	DEFB4A	defensin, beta 4A	11.0	Publications
31	PTH	parathyroid hormone	11.0	Publications
32	ANXA6	annexin A6	11.0	Publications
33	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
34	ANXA11	annexin A11	11.0	Publications
35	BMP4	bone morphogenetic protein 4	11.0	Publications
36	BMP2	bone morphogenetic protein 2	11.0	Publications
37	PLG	plasminogen	11.0	Publications
38	ANXA2	annexin A2	11.0	Publications
39	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
40	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0	Publications
41	COG2	component of oligomeric golgi complex 2	11.0	Publications
42	CTGF	connective tissue growth factor	11.0	Publications
43	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
44	CABIN1	calcineurin binding protein 1	11.0	Publications
45	ALPP	alkaline phosphatase, placental	11.0	Publications
46	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
47	LRP5	low density lipoprotein receptor-related protein 5	11.0	Publications
48	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
49	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
50	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications

Pathways related to osteonecrosis according to GeneDecks:

(show top 50)    (show all 81)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.5	BMP4, BMP7, CTGF
2	Extrinsic Prothrombin Activation Pathway36	10.5	F2, F3, TFPI, F5, SERPINC1
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.2	RUNX2, COL2A1, PTH, TNFSF11, BGLAP, VDR
4	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.2	RUNX2, BGLAP, TNFSF11, PTH, PTH1R, VDR
5	Blood Coagulation Cascade36	10.2	COL2A1, TFPI, F2, F3, F5, SERPINC1
6	Akt Signaling36	10.1	VEGFC, PROK1, CTGF, TNFSF11, BMPR2, BMP7
7	Blood Coagulation Signaling Pathways37	10.1	TFPI, F2, F3, F5, PLG, VWF
8	TGF-beta signaling pathway20	10.1	COMP, CREBBP, BMPR2, BMP7, BMP6, BMP4
9	eIF2 Pathway36	10.1	PROK1, CTGF, BMP7, VEGFC, BMP6, BMP4
10	Complement and coagulation cascades20	10.1	SERPINE1, VWF, SERPINC1, F5, F3, F2
11	Cardiomyocyte Differentiation through BMP Receptors36	10.0	BMPR2, BMP7, BMP4, BMP2
12	Glioma Invasiveness36	10.0	PLG, BMP7, VEGFC, BMP6, BMP4, BMP2
13	Rac1 Pathway36	9.8	BMP6, BMP7, KDR, CTGF, PROK1, NRP1
14	Selected targets of C/EBPalpha10	9.8	TFAP2A, CD36, APOB, TF, SERPINC1
15	CREB Pathway36	9.8	PROK1, BMP6, BMP7, KDR, NRP1, CREBBP
16	PPAR Pathway36	9.7	NRP1, CREBBP, PPARG, CTGF, BMP4, BMP2
17	Platelet activation, signaling and aggregation38	9.7	PLG, APOA1, VEGFC, CD36, VWF
18	NF-KappaB (p50-p65) Pathway36	9.7	BMP7, KDR, PROK1, VEGFC, BMP2, BMP4
19	DHA Signaling36	9.6	CTGF, BMP7, BMP6, PROK1, BMP4, BMP2
20	NF-KappaB Family Pathway36	9.6	BMP4, VEGFC, BMP7, KDR, CTGF, CREBBP
21	ERK5 Signaling36	9.6	BMP4, KDR, CTGF, BMP6, NRP1, BMP7
22	Nuclear Receptor Activation by Vitamin-A36	9.5	CTGF, CREBBP, BMP7, BMP6, BMP4, BMP2
23	IP3 Pathway36	9.5	BMP6, CREBBP, CTGF, BMP4, PROK1, KDR
24	Activation of PKC through GPCR36	9.5	BMP2, PROK1, BMP6, VEGFC, BMP4, BMP7
25	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.5	TNFRSF11B, BGLAP, RUNX2, NR3C1, VDR, PTH1R
26	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.5	PTH, TNFRSF11B, CALCA, BGLAP, VDR, PTH1R
27	TGF-Beta Pathway36	9.5	CTGF, PROK1, CREBBP, VEGFC, KDR, BMP6
28	p70S6K Signaling36	9.4	BMP7, BMP6, KDR, BMP4, CTGF, NRP1
29	mTOR Pathway36	9.4	CTGF, BMP7, BMP6, BMP4, BMP2, HIF1A
30	PTEN Pathway36	9.4	PROK1, NRP1, CTGF, TP53, KDR, BMP7
31	PAK Pathway36	9.4	NRP1, BMP6, TNFSF11, BMP7, CTGF, BMP4
32	eNOS Signaling36	9.4	BMP6, BMP2, BMP7, ESR1, NOS3
33	Phospholipase-C Pathway36	9.3	COL2A1, VEGFC, BMP2, BMP4, BMP6, BMP7
34	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.3	TP53, CAT, ABCB1, NOS3
35	Antioxidant Action of Vitamin-C36	9.2	VEGFC, BMP2, BMP4, BMP7, BMPR2, KDR
36	Renin-Angiotensin Pathway36	9.2	ACE, CTGF, VEGFC, KDR, BMP7, BMP6
37	JAK-STAT Pathway36	9.2	BMP6, PROK1, BMP7, F2, CTGF, CREBBP
38	Apoptotic Pathways in Synovial Fibroblasts36	9.2	KDR, CTGF, PROK1, VEGFC, NRP1, TP53
39	p53 Mediated Apoptosis36	9.2	BMP4, BMP2, BMP7, KDR, PROK1, VEGFC
40	Telomerase Components in Cell Signaling36	9.2	CTGF, KDR, TP53, PROK1, BMP4, BMP2
41	Mitochondrial Apoptosis36	9.2	BMP4, BMP2, BMP6, VEGFC, BMP7, KDR
42	Cellular Apoptosis Pathway36	9.2	BMP2, PROK1, NRP1, CTGF, TP53, KDR
43	Pancreatic Adenocarcinoma36	9.0	CTGF, PROK1, TP53, KDR, BMP7, BMP4
44	Cytokine-cytokine receptor interaction20	9.0	TNFRSF11B, IL23R, IL17A, KDR, BMPR2, BMP7
45	p38 Signaling36	8.8	BMP2, VEGFC, BMP4, BMP6, TNFSF11, PROK1
46	Estrogen Pathway36	8.5	PROK1, BMP2, VEGFC, NCOA2, BMP6, BMP7
47	Selected targets of ESR110	8.5	BMP4, BMP6, ESR1, ABCB1, TF, TP53
48	Molecular Mechanisms of Cancer36	8.4	VEGFC, KDR, IL23R, BMPR2, BMP7, TP53
49	Transcription Ligand-dependent activation of the ESR1/SP pathway10	8.4	TYMS, HIF1A, CREBBP, ESR1, VEGFA
50	Transcription_Ligand-dependent activation of the ESR1/SP pathway41	8.1	HIF1A, CREBBP, ESR1, VEGFA, TYMS

Compounds related to osteonecrosis according to GeneDecks:

(show top 50)    (show all 413)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.8	APOH, CYP2C8
2	steroid32	10.7	BMP2, F5, TNFRSF11B, PLG
3	glucose32	10.1	VEGFC, BMP7, PTH, CTGF, PLG, COMP
4	ly29400232	9.7	VEGFA, IL17A, ANXA5, TNFRSF11B, TNFSF11, SREBF1
5	titanium32	9.4	BMP2, BMP4, BMP7, BGLAP, CD36, ALPP
6	betacarotene32	9.2	VWF, MTHFR, APOB, APOH, ANXA5, ALDH2
7	aspartate32	9.1	VDR, BMP6, APOA1, F5, F2, ALPL
8	warfarin32 34 9 18 9	13.0	VWF, SERPINC1, BGLAP, MTHFR, APOB, APOH
9	fluvastatin32 34 9 9	12.0	COG2, VWF, SERPINE1, BMP2, APOA1, APOB
10	fibrinogen32	9.0	COG2, SERPINC1, SERPINE1, APOA1, APOB, APOH
11	homocysteine32 18	9.9	COG2, VWF, SERPINC1, SERPINE1, APOA1, APOB
12	deoxypyridinoline32	8.9	VDR, BGLAP, CD36, IGFBP3, ALPP, TNFRSF11B
13	progesterone32 42 9 18 9	12.8	NCOA2, VEGFC, BMP2, BMP4, BMP7, BMPR2
14	arginine32	8.7	COG2, NCOA2, VWF, SERPINC1, VDR, BMP2
15	procollagen32	8.6	BMP2, BMP6, BGLAP, CD36, IGFBP3, ALPP
16	1,25 dihydroxy vitamin d332	8.6	LRP5, VDR, BMP2, BMP6, BGLAP, IGFBP3
17	ascorbic acid32 18	9.6	VDR, BMP2, BMP4, BMP7, BGLAP, CD36
18	heparin32 9 18 9	11.5	COG2, VWF, SERPINE1, VEGFC, BMP4, BGLAP
19	calcitriol32 42 9 18 9	12.5	NCOA2, VDR, BMP2, BMP6, BMP7, BGLAP
20	alendronate32 9 9	10.3	VDR, BMP2, BGLAP, CD36, ALPP, CALCA
21	cysteine32	8.3	VDR, BMP4, BGLAP, PAG1, KDR, MTHFR
22	pge232	8.2	BMP2, BMP4, BMP7, IL17A, APOA1, TNFRSF11B
23	folate32	8.0	VWF, SERPINC1, VDR, KDR, MTHFR, APOB
24	calcium32 9 18 9	10.8	LRP5, COG2, KL, VWF, VEGFC, BMP2
25	atorvastatin32 34 9 18 9	11.8	COG2, VWF, VEGFA, BMP2, BMP6, APOA1
26	testosterone32 9 18 9	10.5	COG2, NCOA2, SERPINC1, VEGFC, VDR, BMP2
27	sb 20358032 42	8.5	VEGFA, VDR, BMP2, BMP4, BMP6, BGLAP
28	thymidine32 18	8.3	VEGFC, VDR, BMP2, BMP4, BMP6, BMP7
29	methotrexate32 34 42 9 9	11.3	SERPINE1, BMP6, MTHFR, IL17A, APOH, IGFBP3
30	raloxifene32 9 9	9.3	VWF, SERPINC1, VDR, BMP2, BGLAP, CD36
31	tacrolimus32 34 9 9	10.1	SERPINE1, VDR, BMP2, BMP6, CD36, IL17A
32	prostacyclin32	7.0	VWF, SERPINC1, SERPINE1, VEGFA, BMP6, KDR
33	lactate32	6.9	VWF, BMP2, BMP6, KDR, APOA1, APOB
34	creatinine32	6.9	VWF, SERPINC1, VDR, BMP2, BMP6, BMP7
35	cyclosporin a32 42	7.8	COG2, VWF, VDR, BMP2, BMP4, BMP6
36	lipid32	6.8	LRP5, COG2, SERPINE1, VEGFC, BMP2, BMP7
37	retinoid32	6.7	NCOA2, VDR, BMP2, BMP4, BMP6, IL17A
38	simvastatin32 34 42 9 18 9	11.7	COG2, VWF, SERPINE1, VEGFA, BMP2, BMP6
39	nitric oxide32 9 18 9	9.5	COG2, VWF, SERPINE1, VEGFC, BMP2, BMP4
40	cholesterol32 9 18 9	9.5	LRP5, COG2, NCOA2, VWF, SERPINE1, BMP2
41	paclitaxel32 34 9 9	9.4	VEGFA, BMP6, KDR, ANXA5, ANXA2, IGFBP3
42	alanine32	6.3	COG2, VWF, SERPINC1, VDR, BMP2, BMP6
43	genistein32 9 18 9	9.0	NCOA2, SERPINE1, VEGFA, VDR, BMP2, KDR
44	vitamin d32	5.8	LRP5, NCOA2, SERPINE1, VDR, BMP2, BMP6
45	cycloheximide32	4.9	SERPINE1, VEGFA, VDR, BMP2, BMP4, BMP6
46	serine32	4.9	VWF, SERPINC1, SERPINE1, VDR, BMP2, BMP4
47	dexamethasone32 42 34 9 9	8.2	NCOA2, VWF, SERPINC1, SERPINE1, VEGFA, VEGFC
48	estrogen32	4.2	LRP5, COG2, NCOA2, VWF, SERPINC1, SERPINE1
49	vegf32	4.0	KL, VWF, SERPINC1, SERPINE1, VEGFC, BMP2
50	retinoic acid32 42 18	5.9	NCOA2, VWF, SERPINE1, VEGFC, VDR, BMP2

Cellular components related to osteonecrosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	10.0	BGLAP, BMP4, BMP2
2	platelet alpha granule lumen	GO:031093	9.2	PLG, F5, VEGFC, VEGFA, SERPINE1, VWF
3	cell surface	GO:009986	8.9	VEGFA, BMP2, BMPR2, CD36, APOH, ALPP
4	extracellular region	GO:005576	6.2	NRP1, CTGF, CYR61, PTH, TNFSF11, TNFRSF11B
5	extracellular space	GO:005615	6.1	PON1, F2, ALPL, CALCA, TNFRSF11B, TNFSF11
6	plasma membrane	GO:005886	5.8	CTGF, PTH1R, ESR1, CAT, ALPPL2, ALPP

Biological processes related to osteonecrosis according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	bone morphogenesis	GO:060349	10.6	TFAP2A, ACP5, MSX1, LRP5
2	negative regulation of fibrinolysis	GO:051918	10.5	PLG, F2, APOH, SERPINE1
3	bone resorption	GO:045453	10.5	TNFSF11, PTH, PTH1R, ACP5
4	positive regulation of BMP signaling pathway	GO:030513	10.5	CYR61, MSX1, BMPR2, BMP4
5	positive regulation of cartilage development	GO:061036	10.4	CYR61, BMP4, BMP2
6	positive regulation of blood coagulation	GO:030194	10.3	F2, APOH, CD36, SERPINE1
7	response to mechanical stimulus	GO:009612	10.3	NOS3, F3, BGLAP, BMP4, BMP2
8	SMAD protein signal transduction	GO:060395	10.3	BMP7, BMP6, BMP4, BMP2
9	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.2	BMPR2, BMP7, BMP6, BMP4, BMP2
10	osteoblast differentiation	GO:001649	10.2	RUNX2, CYR61, BGLAP, BMP6, BMP4, BMP2
11	positive regulation of osteoblast differentiation	GO:045669	10.2	CYR61, BMPR2, BMP7, BMP6, BMP4, BMP2
12	cellular response to growth factor stimulus	GO:071363	10.2	TGIF1, CAT, HTR3A, BMP4, BMP2
13	positive regulation of ossification	GO:045778	10.1	CALCA, BMP4, BMP2
14	BMP signaling pathway	GO:030509	10.1	BMPR2, BMP7, BMP6, BMP4, BMP2
15	positive regulation of bone mineralization	GO:030501	10.1	TFAP2A, PTH, BMPR2, BMP7, BMP6, BMP4
16	organ morphogenesis	GO:009887	10.0	COMP, NRP1, TNFSF11, BMP2, VDR, VEGFC
17	cartilage development	GO:051216	9.9	HIF1A, COL2A1, BMP7, BMP6, BMP2
18	positive regulation of protein phosphorylation	GO:001934	9.8	CTGF, CYR61, F2, BMP4, BMP2, VEGFA
19	skeletal system development	GO:001501	9.8	VDR, COL2A1, COMP, PTH1R, PTH, TNFRSF11B
20	aging	GO:007568	9.8	NOS3, NR3C1, PTH1R, CALCA, F3, VDR
21	cholesterol transport	GO:030301	9.7	APOB, APOA1, CD36
22	positive regulation of endothelial cell migration	GO:010595	9.6	NRP1, KDR, BMPR2, BMP4, VEGFA
23	positive regulation of positive chemotaxis	GO:050927	9.6	VEGFA, KDR, F3
24	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.5	NRP1, KDR, BMPR2, VEGFC, VEGFA
25	positive regulation of apoptotic process	GO:043065	9.5	NOS3, CYR61, TP53, IGFBP3, ANXA5, MSX1
26	response to estradiol stimulus	GO:032355	9.3	NOS3, CTGF, ESR1, F3, BMP4, VDR
27	lipoprotein transport	GO:042953	9.3	APOB, CD36, PPARG
28	negative regulation of cell proliferation	GO:008285	9.2	TFAP2A, TGIF1, NOS3, PLG, PTH1R, TP53
29	regulation of blood pressure	GO:008217	9.2	ACE, NOS3, PPARG, CALCA, LRP5
30	positive regulation of angiogenesis	GO:045766	9.1	HIF1A, NOS3, F3, KDR, VEGFA, SERPINE1
31	response to estrogen stimulus	GO:043627	9.1	PPARG, TNFRSF11B, ESR1, BGLAP, SERPINE1
32	negative regulation of apoptotic process	GO:043066	8.9	TFAP2A, COL2A1, CYR61, TP53, CAT, MSX1
33	positive regulation of endothelial cell proliferation	GO:001938	8.9	HIF1A, NRP1, F3, KDR, BMPR2, BMP6
34	angiogenesis	GO:001525	8.8	PROK1, HIF1A, NOS3, NRP1, CTGF, ANXA2
35	cellular response to hypoxia	GO:071456	8.8	HIF1A, CREBBP, TP53, BMP7, VEGFA
36	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.8	PPARG, CREBBP, TGIF1, TFAP2A, DKK1, PTH
37	platelet degranulation	GO:002576	8.6	TF, PLG, F5, APOA1, CD36, VEGFC
38	transcription initiation from RNA polymerase II promoter	GO:006367	8.5	RUNX2, TGIF1, CREBBP, NR3C1, PPARG, CTGF
39	platelet activation	GO:030168	8.5	F5, F2, PLG, TF, APOA1, CD36
40	small molecule metabolic process	GO:044281	8.3	CTGF, CREBBP, NOS3, ABCB1, ACP5, TYMS
41	positive regulation of transcription, DNA-dependent	GO:045893	8.3	RUNX2, TFAP2A, HIF1A, CREBBP, PPARG, TP53
42	blood coagulation	GO:007596	7.3	F3, F2, TP53, PLG, NOS3, TF
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.5	TP53, TNFSF11, PTH, CYR61, SREBF1, PPARG

Molecular functions related to osteonecrosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium-dependent phospholipid binding	GO:005544	10.2	ANXA5, ANXA11, ANXA6, ANXA2
2	BMP receptor binding	GO:070700	10.2	BMP6, BMP4, BMP2
3	alkaline phosphatase activity	GO:004035	10.0	ALPL, ALPP, ALPPL2
4	heparin binding	GO:008201	9.4	COMP, NRP1, CTGF, CYR61, APOH, APOB
5	protease binding	GO:002020	9.3	TP53, F3, SERPINE1, SERPINC1, VWF
6	cytokine activity	GO:005125	9.1	TNFSF11, TNFRSF11B, IL17A, BMP7, BMP6, BMP4
7	growth factor activity	GO:008083	9.1	PROK1, DKK1, CTGF, F2, BMP7, BMP6
8	enzyme binding	GO:019899	7.4	HIF1A, PPARG, CYP3A4, TP53, ESR1, CAT
9	protein binding	GO:005515	2.2	RUNX2, NR3C1, PPARG, SREBF1, TP53, ESR1