MCID: OST003
MIFTS: 59

Osteonecrosis malady

Bone diseases category
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Summaries for Osteonecrosis

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MedlinePlus:33 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. in people with healthy bones, new bone is always replacing old bone. in osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. the bone starts to die and may break down. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. at first, you might not have any symptoms. as the disease gets worse, you will probably have joint pain that becomes more severe. you may not be able to bend or move the affected joint very well. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer doctors use imaging tests and other tests to diagnose osteonecrosis. treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Osteonecrosis, also known as avascular necrosis of bone, is related to osteomyelitis and periodontitis. An important gene associated with Osteonecrosis is OPN1LW (opsin 1 (cone pigments), long-wave-sensitive), and among its related pathways is Defensins. The compounds hbd2 and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes, and related mouse phenotype limbs/digits/tail.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in bone.

Wikipedia:65 Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and... more...

Aliases & Classifications for Osteonecrosis

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Related Diseases for Osteonecrosis

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Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis30.7ACP5, BMP2
2periodontitis30.5DEFB4A, DEFB1
3osteoporosis30.3BMP2, ACP5, PTH
4periodontal disease30.2DEFB4A, DEFB1
5cholesteatoma30.1DEFB1, DEFB4A
6renal osteodystrophy30.1PTH, ACP5
7osteoarthritis30.1BMP2, DEFB4A, ACP5
8osteonecrosis of the jaw11.1
9dysbaric osteonecrosis10.7
10endotheliitis10.4
11oral candidiasis10.4DEFB4A
12leukemia10.4
13candidiasis10.4DEFB4A
14arthritis10.4
15systemic lupus erythematosus10.4
16lupus erythematosus10.4
17thrombophilia10.4
18myeloma10.3
19multiple myeloma10.3
20acute lymphoblastic leukemia10.3
21lymphoblastic leukemia10.3
22tonsillitis10.3DEFB1, DEFB4A
23duodenal ulcer10.3DEFB1, DEFB4A
24rheumatoid arthritis10.3
25slipped capital femoral epiphysis10.3
26adult acute lymphocytic leukemia10.2
27islet cell tumor10.2
28osteochondrosis10.2
29dyskeratosis congenita10.2
30cushing's syndrome10.2
31rheumatoid vasculitis10.2
32breast cancer10.2
33gaucher's disease10.2
34osteogenesis imperfecta10.2
35secondary non-traumatic avascular necrosis10.2
36gastritis10.1DEFB4A, DEFB1
37colitis10.1DEFB4A, DEFB1
38avascular necrosis of the femoral head10.1
39severe acute respiratory syndrome10.1
40septic arthritis10.1
41herpes zoster10.1
42disseminated intravascular coagulation10.1
43neuropathy10.1
44periostitis10.1
45hypoxia10.1
46blindness10.1
47cleft palate10.1BMP2, MSX1
48osteosclerosis10.0PTH, BMP2
49hepatitis10.0
50osteochondritis dissecans10.0

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to osteonecrosis

Symptoms for Osteonecrosis

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Drugs & Therapeutics for Osteonecrosis

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Drug clinical trials:

Search ClinicalTrials for Osteonecrosis

Search NIH Clinical Center for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677

Genetic Tests for Osteonecrosis

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Anatomical Context for Osteonecrosis

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MalaCards organs/tissues related to Osteonecrosis:

32
Bone, Testes, Skin, Endothelial, Bone marrow, Breast, Kidney, Liver, Prostate, T cells, Adipocyte, Lung, Thyroid

FMA organs/tissues related to Osteonecrosis:

14
Bone

Animal Models for Osteonecrosis or affiliated genes

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MGI Mouse Phenotypes related to Osteonecrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.1BMP2, ACP5, MSX1, PTH

Publications for Osteonecrosis

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Articles related to Osteonecrosis:

(show top 50)    (show all 728)
idTitleAuthorsYear
1
Mandibular osteonecrosis and Ramsay Hunt syndrome following a case of herpes zoster. (25234535)
2014
2
Dramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal. (25327450)
2014
3
Incongruities in the AAOMS Position Paper: Medication-Related Osteonecrosis of the Jaw-2014 Update. (25315315)
2014
4
Mandibulectomy and free flap reconstruction for bisphosphonate-related osteonecrosis of the jaws. (24051498)
2013
5
An unusual complication in osteonecrosis of femoral head: a case report. (23401822)
2013
6
Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis. (23696921)
2013
7
Interleukin-6 concentration changes in plasma and saliva in bisphosphonate-related osteonecrosis of the jaws. (23837828)
2013
8
Arthroscopically assisted fibular strut allograft for treatment of osteonecrosis of proximal humerus. (24393185)
2013
9
Association between PAI-1 4G/5G Polymorphisms and osteonecrosis of femoral head: a meta-analysis. (23856555)
2013
10
Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate. (23941019)
2013
11
Osteonecrosis of the jaw in a patient with rheumatoid artritis treated with an oral aminobisphosphonate: a clinical case report. (24133533)
2013
12
Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw: reply to Subramanian and Quek. (22581291)
2013
13
Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. (23645686)
2013
14
There are many potential medical therapies for atraumatic osteonecrosis. (23041599)
2013
15
Total hip arthroplasty in steroid-induced osteonecrosis: early functional and radiological outcomes. (22992403)
2013
16
Combination of zoledronic Acid and targeted therapy is active but may induce osteonecrosis of the jaw in patients with metastatic renal cell carcinoma. (23642545)
2013
17
C-terminal cross-linking telopeptide as a serologic marker for bisphosphonate-related osteonecrosis of the jaw: review of 2 cases. (23920073)
2013
18
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
19
Nontraumatic osteonecrosis of the femoral head: endoscopic visualization of its avascular burden. (22955395)
2012
20
Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids: a multicenter case-control study in Japan. (22927108)
2012
21
Predictive role of cytokine gene polymorphisms for the development of femoral head osteonecrosis. (22975999)
2012
22
Early results of a novel technique using multiple small tantalum pegs for the treatment of osteonecrosis of the femoral head: a case series involving 26 hips. (22323681)
2012
23
CORR insights: Reliability of Bucholz and Ogden classification for osteonecrosis secondary to developmental dysplasia of the hip. (22903284)
2012
24
Bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. (22962894)
2012
25
Mandibular bisphosphonate-related osteonecrosis after dental implant rehabilitation: a case report. (23075811)
2012
26
Oral cancer: comprehending the condition, causes, controversies, control and consequences. 17. Osteonecrosis. (22852516)
2012
27
Can local Erythropoietin administration enhance bone regeneration in osteonecrosis of femoral head? (22617757)
2012
28
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
29
The effects of autologous bone marrow mesenchymal stem cell arterial perfusion on vascular repair and angiogenesis in osteonecrosis of the femoral head in dogs. (23064553)
2012
30
Vascular endothelial growth factor -634G/C polymorphism associated with osteonecrosis of the femoral head in a Chinese population. (22612467)
2012
31
Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. (22340480)
2012
32
Physiology and pharmacology of nonbisphosphonate drugs implicated in osteonecrosis of the jaw. (22985897)
2012
33
Association of osteonecrosis and peripheral neuropathy in HIV-1-infected patients: possible roles of nerve growth factor and vascular endothelial growth factor. (22067199)
2011
34
Vascular endothelial growth factor genetic polymorphisms and haplotypes in female patients with bisphosphonate-related osteonecrosis of the jaws. (21251073)
2011
35
A current update on osteonecrosis of the jaw and bisphosphonates. (22408887)
2011
36
Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. (21752301)
2011
37
Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis. (19575201)
2010
38
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. (20929185)
2010
39
Different differentiation of stroma cells from patients with osteonecrosis: a pilot study. (19330390)
2009
40
Coagulopathies frequency in aseptic osteonecrosis patients. (19211287)
2009
41
Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population. (19345290)
2009
42
Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. (22752739)
2009
43
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis. (18719618)
2008
44
Peroxisome proliferator-activated receptor-gamma gene polymorphisms are not associated with osteonecrosis of the femoral head in the Korean population. (18182855)
2007
45
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. (15784727)
2005
46
Hyperbaric oxygen therapy for idiopathic osteonecrosis of the femoral head in adults: Executive summary of final report N06-01D, Version 1.0 (23101065)
2005
47
Type II collagen gene variants and inherited osteonecrosis of the femoral head. (15930420)
2005
48
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
49
Radiology rounds. KienbAPck's disease (osteonecrosis of the lunate). (9721413)
1998
50
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. (2396333)
1990

Variations for Osteonecrosis

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Expression for genes affiliated with Osteonecrosis

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Expression patterns in normal tissues for genes affiliated with Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for genes affiliated with Osteonecrosis

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Pathways related to Osteonecrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DEFB1, DEFB4A

Compounds for genes affiliated with Osteonecrosis

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Compounds related to Osteonecrosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1hbd24410.1DEFB1, DEFB4A
2ticlopidine44 1111.0APOH, CYP2C8
3cerivastatin50 44 28 1112.9BMP2, CYP2C8
4lipoteichoic acid449.9DEFB4A, APOH
5raloxifene44 50 28 1112.9CYP2C8, BMP2
6warfarin44 50 24 1112.8APOH, CYP2C8
7diethylstilbestrol44 28 1111.8ACP5, CYP2C8
8fluvastatin44 50 28 1112.8BMP2, CYP2C8
9pamidronate44 50 1111.7PTH, CYP2C8
10titanium449.7BMP2, ACP5
11deoxyribonucleic acid449.7BMP2, APOH
12pravastatin44 50 28 24 1113.6BMP2, CYP2C8
13cyclophosphamide44 50 1111.5CYP2C8, APOH, BMP2
14alendronate44 50 1111.5BMP2, PTH
15hydroxyapatite449.4BMP2, ACP5
16rantes449.4ACP5, DEFB1, DEFB4A
17deoxypyridinoline449.4PTH, ACP5
1825-hydroxyvitamin d449.3PTH, ACP5
19ethanol44 50 24 1112.3ACP5, APOH, CYP2C8
20androstenedione44 2410.3PTH, CYP2C8
21hydroxyproline44 24 1111.3ACP5, PTH
22tetracycline44 1110.2ACP5, BMP2
23azathioprine44 2 50 1112.2BMP2, ACP5, APOH
24polyacrylamide449.2BMP2, ACP5, APOH
25steroid449.1DEFB4A, APOH, PROK1, BMP2
26polyethylene glycol449.0BMP2, ACP5
27phosphorus448.9PTH, APOH, ACP5
28procollagen448.9BMP2, ACP5, PTH
291,25 dihydroxy vitamin d3448.9PTH, ACP5, BMP2
30calcitriol44 61 24 1111.9BMP2, ACP5, PTH
31vitamin d448.8PTH, ACP5, BMP2
32heparin44 28 24 1111.8BMP2, ACP5, APOH, DEFB4A
33progesterone44 28 61 24 1112.8DEFB4A, CYP2C8, APOH, PROK1, BMP2
34retinoic acid44 249.8DEFB4A, DEFB1, CYP2C8, MSX1, BMP2
35oxygen44 249.8BMP2, ACP5, APOH, CYP2C8
36estradiol44 24 1110.7DEFB4A, CYP2C8, PTH, ACP5
37pge2448.7PTH, ACP5, BMP2
38vegf448.7PTH, APOH, PROK1, BMP2
39glucose448.5BMP2, APOH, PTH, DEFB1
40lipid448.5DEFB4A, APOH, ACP5, BMP2
41creatinine448.4PTH, APOH, ACP5, BMP2
42nitric oxide44 24 1110.4PTH, APOH, ACP5, BMP2
43tyrosine448.1DEFB4A, CYP2C8, PTH, ACP5, BMP2
44estrogen448.0BMP2, ACP5, APOH, PTH, DEFB4A
45dexamethasone44 50 28 1110.8BMP2, ACP5, PTH, CYP2C8, DEFB1, DEFB4A
46calcium44 50 24 1110.4DEFB4A, PTH, APOH, PROK1, ACP5, BMP2

GO Terms for genes affiliated with Osteonecrosis

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Cellular components related to Osteonecrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7DEFB1, DEFB4A
2extracellular regionGO:0055767.7BMP2, PROK1, PTH, DEFB1, DEFB4A

Biological processes related to Osteonecrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bone morphogenesisGO:0603499.5MSX1, ACP5
2odontogenesis of dentin-containing toothGO:0424759.4MSX1, BMP2
3activation of MAPK activityGO:0001879.3PROK1, BMP2
4positive regulation of bone mineralizationGO:0305019.2PTH, BMP2
5bone resorptionGO:0454539.2PTH, ACP5
6G-protein coupled receptor signaling pathwayGO:0071868.9DEFB1, DEFB4A, PTH
7negative regulation of transcription from RNA polymerase II promoterGO:0001228.7PTH, MSX1, BMP2

Products for genes affiliated with Osteonecrosis

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Sources for Osteonecrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet