MCID: OST003
MIFTS: 51

Osteonecrosis malady

Bone diseases category

Summaries for Osteonecrosis

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. in people with healthy bones, new bone is always replacing old bone. in osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. the bone starts to die and may break down. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. at first, you might not have any symptoms. as the disease gets worse, you will probably have joint pain that becomes more severe. you may not be able to bend or move the affected joint very well. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer doctors use imaging tests and other tests to diagnose osteonecrosis. treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteonecrosis, also known as avascular necrosis of bone, is related to osteoporosis and myeloma. An important gene associated with Osteonecrosis is OPN1LW (opsin 1 (cone pigments), long-wave-sensitive), and among its related pathways is Beta defensins. The compounds hbd2 and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in bone.

Wikipedia:63 Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and... more...

Aliases & Classifications for Osteonecrosis

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Osteonecrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.5ALPPL2, ACP5, DKK1
2myeloma30.4DKK1, ACP5, ALPPL2
3multiple myeloma30.4DKK1
4renal osteodystrophy30.1ALPPL2, ACP5
5paget's disease of bone29.7ALPPL2
6periodontal disease29.7DEFB1, DEFB103B, DEFB4A
7dysbaric osteonecrosis10.6
8jaw cancer10.4
9leukemia10.4
10systemic lupus erythematosus10.3
11lupus erythematosus10.3
12thrombophilia10.3
13arthritis10.3
14osteomyelitis10.3
15acute leukemia10.3
16lymphoblastic leukemia10.2
17dyskeratosis congenita10.2
18adult acute lymphocytic leukemia10.2
19islet cell tumor10.2
20osteochondrosis10.2
21myxedema10.2
22breast cancer10.2
23rheumatoid arthritis10.2
24osteoarthritis10.1
25severe acute respiratory syndrome10.1
26gaucher's disease10.1
27osteopetrosis10.1
28septic arthritis10.1
29osteogenesis imperfecta10.1
30childhood leukemia10.1
31disseminated intravascular coagulation10.1
32neuropathy10.1
33avascular necrosis of the femoral head10.1
34oral candidiasis10.0DEFB4A
35candidiasis10.0DEFB4A
36tonsillitis10.0DEFB4A, DEFB1
37sarcoidosis10.0DEFB4A, DEFB1
38cholesteatoma10.0DEFB4A, DEFB1
39sinusitis10.0DEFB4A
40inflammatory bowel disease10.0ALPPL2
41choriocarcinoma10.0ALPPL2
42pigmented villonodular synovitis10.0
43kummell's disease10.0
44villonodular synovitis10.0
45hyperhomocysteinemia10.0
46protein s deficiency10.0
47herpes zoster10.0
48osteochondritis dissecans10.0
49hepatitis10.0
50ischemia10.0

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to osteonecrosis

Clinical Features for Osteonecrosis

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Drugs & Therapeutics for Osteonecrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Osteonecrosis

Drug clinical trials:

Search ClinicalTrials for Osteonecrosis

Search NIH Clinical Center for Osteonecrosis

Search CenterWatch for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677

Genetic Tests for Osteonecrosis

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Anatomical Context for Osteonecrosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteonecrosis:

32
Bone, Testes, Skin, Endothelial, Bone marrow, Breast, Kidney, Liver, T cells, Prostate, Lung, Adipocyte

FMA organs/tissues related to Osteonecrosis:

14
Bone

Animal Models for Osteonecrosis or affiliated genes

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Publications for Osteonecrosis

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50PubMed
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Articles related to Osteonecrosis:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies. (24203085)
2014
2
Diabetes mellitus and corticotherapy as risk factors for alendronate-related osteonecrosis of the jaws: A study in Wistar rats. (23649954)
2014
3
Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system. (24332520)
2014
4
Total hip arthroplasty in steroid-induced osteonecrosis: early functional and radiological outcomes. (22992403)
2013
5
Primary epiphyseal arteriopathy in a mouse model of steroid-induced osteonecrosis. (23673001)
2013
6
Osteonecrosis of the femoral head in a patient with Henoch-SchAPnlein purpura and drug-induced hypersensitivity syndrome treated with corticosteroids. (22854786)
2013
7
Preventive oral surgery before bisphosphonate administration to reduce osteonecrosis of the jaws. (24330028)
2013
8
Dental extraction as a risk factor for bisphosphonate related osteonecrosis of the jaw in cancer patients: an update. (24073539)
2013
9
Emerging concepts in the management and treatment of osteonecrosis of the jaw. (23159218)
2013
10
Reduced head-neck offset in nontraumatic osteonecrosis of the femoral head. (23712709)
2013
11
Treatment of osteonecrosis of the femoral head with thorough debridement, bone grafting and bone-marrow mononuclear cells implantation. (23412306)
2013
12
Meniscal extrusion and spontaneous osteonecrosis with root tear of medial meniscus: comparison with horizontal tear. (23395469)
2013
13
Cementless total hip arthroplasty in patients with osteonecrosis after kidney transplantation. (23498872)
2013
14
Therapeutic effect of minimally invasive decompression combined with impaction bone grafting on osteonecrosis of the femoral head. (23412266)
2013
15
Unilateral free vascularized fibula shared for the treatment of bilateral osteonecrosis of the femoral head. (23122874)
2013
16
Diabetes microvascular disease and the risk for bisphosphonate-related osteonecrosis of the jaw: a single center study. (24037883)
2013
17
Bisphosphonates-related osteonecrosis of the jaws: a preliminary study of salivary interleukins. (23157469)
2013
18
An unusual complication of tooth exfoliation and osteonecrosis following herpes zoster infection of trigeminal nerve: a case report and literature review. (23828260)
2013
19
Cell therapy in bisphosphonate-related osteonecrosis of the jaw. (23714970)
2013
20
Osteonecrosis of the femoral head in childhood malignancy. (24432068)
2013
21
Bisphosphonate-associated osteonecrosis of the auditory canal. (23523149)
2013
22
Torus palatinus osteonecrosis related to bisphosphonate: a case report. (23687490)
2013
23
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
24
Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. (22340480)
2012
25
Physiology and pharmacology of nonbisphosphonate drugs implicated in osteonecrosis of the jaw. (22985897)
2012
26
Bone turnover markers failed to predict the occurrence of osteonecrosis of the femoral head: a preliminary study. (22467318)
2012
27
Principles of oral surgery for prevention of bisphosphonate-related osteonecrosis of the jaw. (23182374)
2012
28
Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. (22840716)
2012
29
Vertebral osteonecrosis in an HIV-infected patient. (22869279)
2012
30
Is unicompartmental arthroplasty an acceptable option for spontaneous osteonecrosis of the knee? (22278850)
2012
31
The effect of core decompression on local expression of BMP-2, PPAR-I^ and bone regeneration in the steroid-induced femoral head osteonecrosis. (22876776)
2012
32
The suppression of TRIM21 and the accumulation of IFN-I+ play crucial roles in the pathogenesis of osteonecrosis of the femoral head. (22825687)
2012
33
Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats. (22313369)
2012
34
Non-exposed bisphosphonate-related osteonecrosis of the jaw: a critical assessment of current definition, staging, and treatment guidelines. (22420684)
2012
35
Surgical protocol in patients at risk for bisphosphonate osteonecrosis of the jaws: clinical use of serum telopetide CTX in preventive monitoring of surgical risk. (22783453)
2012
36
Effects of non-weight-bearing on the immature femoral head following ischemic osteonecrosis: an experimental investigation in immature pigs. (23318613)
2012
37
Bisphosphonate related osteonecrosis of the jaw: A minipig large animal model. (22575441)
2012
38
A femoral head start: commentary on an article by Harry K.W. Kim, MD, MS, FRCSC, et al.: "effects of non-weight-bearing on the immature femoral head following ischemic osteonecrosis: an experimental investigation in immature pigs". (23318626)
2012
39
The relationship of denosumab pharmacology and osteonecrosis of the jaws. (23159111)
2012
40
Association of osteonecrosis and peripheral neuropathy in HIV-1-infected patients: possible roles of nerve growth factor and vascular endothelial growth factor. (22067199)
2011
41
A current update on osteonecrosis of the jaw and bisphosphonates. (22408887)
2011
42
CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma. (21685474)
2011
43
Necrotizing fasciitis secondary to bisphosphonate-induced osteonecrosis of the jaw. (20015718)
2010
44
Coagulopathies frequency in aseptic osteonecrosis patients. (19211287)
2009
45
A clinical study of femoral head osteonecrosis in patients with systemic lupus erythematosus.]. (20079323)
2009
46
Dysbaric osteonecrosis screening in Turkish Navy divers. (18225777)
2008
47
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
48
Aseptic osteonecrosis in a child with nephroblastoma healed by hyperbaric oxygen therapy. (12116080)
2002
49
Dysbaric osteonecrosis of the femoral diametaphysis. (8502403)
1993
50
Femoral head osteonecrosis in primary hypertrophic osteoarthropathy. (8323391)
1993

Genetic Variations for Osteonecrosis

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Expression for genes affiliated with Osteonecrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteonecrosis

Search GEO for disease gene expression data for Osteonecrosis.

Pathways for genes affiliated with Osteonecrosis

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53Reactome
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Pathways related to Osteonecrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4DEFB4A, DEFB103B, DEFB1

Compounds for genes affiliated with Osteonecrosis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Osteonecrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hbd24410.5DEFB4A, DEFB103B, DEFB1
2ticlopidine44 1111.5CYP2C8, APOH
3progesterone44 59 28 11 2414.4APOH, PROK1, DEFB103B, DEFB4A, DKK1, CYP2C8
4ethanol44 49 11 2413.3APOH, CYP2C8, ACP5, ALPPL2
5dexamethasone44 49 28 1113.1ACP5, CYP2C8, DEFB4A, DEFB103B, DEFB1

GO Terms for genes affiliated with Osteonecrosis

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16Gene Ontology
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Molecular functions related to Osteonecrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:00449710.4CYP27C1, CYP2C8

Products for genes affiliated with Osteonecrosis

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  • Antibodies

Sources for Osteonecrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet