MCID: OST003
MIFTS: 51

Osteonecrosis malady

Bone diseases category

Summaries for Osteonecrosis

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. in people with healthy bones, new bone is always replacing old bone. in osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. the bone starts to die and may break down. you can have osteonecrosis in one or several bones. it is most common in the upper leg. other common sites are your upper arm and your knees, shoulders and ankles. the disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. at first, you might not have any symptoms. as the disease gets worse, you will probably have joint pain that becomes more severe. you may not be able to bend or move the affected joint very well. no one is sure what causes the disease. risk factors include long-term steroid treatment alcohol abuse joint injuries having certain diseases, including arthritis and cancer doctors use imaging tests and other tests to diagnose osteonecrosis. treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteonecrosis, also known as avascular necrosis of bone, is related to osteoporosis and myeloma. An important gene associated with Osteonecrosis is OPN1LW (opsin 1 (cone pigments), long-wave-sensitive), and among its related pathways is Beta defensins. The compounds hbd2 and ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and testes.

Disease Ontology:8 An ischemic bone disease that results in necrosis located in bone.

Wikipedia:63 Avascular necrosis (also osteonecrosis, bone infarction,aseptic necrosis, ischemic bone necrosis, and... more...

Aliases & Classifications for Osteonecrosis

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Osteonecrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteonecrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.5ALPPL2, ACP5, DKK1
2myeloma30.4DKK1, ACP5, ALPPL2
3multiple myeloma30.4DKK1
4renal osteodystrophy30.1ALPPL2, ACP5
5paget's disease of bone29.7ALPPL2
6periodontal disease29.7DEFB1, DEFB103B, DEFB4A
7dysbaric osteonecrosis10.6
8jaw cancer10.4
9leukemia10.4
10systemic lupus erythematosus10.3
11lupus erythematosus10.3
12thrombophilia10.3
13arthritis10.3
14osteomyelitis10.3
15acute leukemia10.3
16lymphoblastic leukemia10.2
17dyskeratosis congenita10.2
18adult acute lymphocytic leukemia10.2
19islet cell tumor10.2
20osteochondrosis10.2
21myxedema10.2
22breast cancer10.2
23rheumatoid arthritis10.2
24osteoarthritis10.1
25severe acute respiratory syndrome10.1
26gaucher's disease10.1
27osteopetrosis10.1
28septic arthritis10.1
29osteogenesis imperfecta10.1
30childhood leukemia10.1
31disseminated intravascular coagulation10.1
32neuropathy10.1
33avascular necrosis of the femoral head10.1
34oral candidiasis10.0DEFB4A
35candidiasis10.0DEFB4A
36tonsillitis10.0DEFB4A, DEFB1
37sarcoidosis10.0DEFB4A, DEFB1
38cholesteatoma10.0DEFB4A, DEFB1
39sinusitis10.0DEFB4A
40inflammatory bowel disease10.0ALPPL2
41choriocarcinoma10.0ALPPL2
42pigmented villonodular synovitis10.0
43kummell's disease10.0
44villonodular synovitis10.0
45hyperhomocysteinemia10.0
46protein s deficiency10.0
47herpes zoster10.0
48osteochondritis dissecans10.0
49hepatitis10.0
50ischemia10.0

Graphical network of the top 20 diseases related to Osteonecrosis:



Diseases related to osteonecrosis

Clinical Features for Osteonecrosis

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Drugs & Therapeutics for Osteonecrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Osteonecrosis

Drug clinical trials:

Search ClinicalTrials for Osteonecrosis

Search NIH Clinical Center for Osteonecrosis

Search CenterWatch for Osteonecrosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Osteonecrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Osteonecrosis:
JACC
Embryonic/Adult Cultured Cells Related to Osteonecrosis:
Cultured cartilage (JACC, PMIDs: 16233778, 19393556, 10738867, 16226641, 11284883, 12043781, 16233853, 19802670, 10679677

Genetic Tests for Osteonecrosis

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Anatomical Context for Osteonecrosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Osteonecrosis:

32
Bone, Testes, Skin, Endothelial, Bone marrow, Breast, Kidney, Liver, T cells, Prostate, Adipocyte, Lung

FMA organs/tissues related to Osteonecrosis:

14
Bone

Animal Models for Osteonecrosis or affiliated genes

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Publications for Osteonecrosis

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50PubMed
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Articles related to Osteonecrosis:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Pseudoepitheliomatous Hyperplasia Associated with Bisphosphonate-related Osteonecrosis of the Jaw. (24425847)
2014
2
Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis. (23696921)
2013
3
Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate. (23941019)
2013
4
A therapeutic efficacy of the transpedicular intracorporeal bone graft with short-segmental posterior instrumentation in osteonecrosis of vertebral body: a minimum 5-year follow-up study. (23197015)
2013
5
Reply to 'Medicolegal considerations in bisphosphonate-related osteonecrosis of the jaw'. (23556544)
2013
6
Prospective biomarker evaluation in patients with osteonecrosis of the jaw who received bisphosphonates. (23954759)
2013
7
The effect of postoperative corticosteroid administration on free vascularized fibular grafting for treating osteonecrosis of the femoral head. (24324377)
2013
8
Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia? (23580637)
2013
9
Prevalence of bisphosphonate-associated osteonecrosis of the jaw after intravenous zoledronate infusions in patients with early breast cancer. (23749244)
2013
10
Hemiarthroplasties in young patients with osteonecrosis or a tumour of the proximal femur; an observational cohort study. (23327536)
2013
11
Treatment of bisphosphonate related osteonecrosis following root canal therapy at the 1-year follow-up: report of two cases. (24353427)
2013
12
Stem cell implantation for osteonecrosis of the femoral head. (24232260)
2013
13
Osteonecrosis of the mandible due to anti-angiogenic agent, bevacizumab. (23242941)
2013
14
Impairment of two types of circulating endothelial progenitor cells in patients with glucocorticoid-induced avascular osteonecrosis of the femoral head. (22503166)
2013
15
Electrically conductive bacterial nanowires in bisphosphonate-related osteonecrosis of the jaw biofilms. (23217537)
2013
16
Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: a retrospective multi-hospital-based study of 87 Italian cases. (23768563)
2013
17
Osteonecrosis of the femoral head: the total hip replacement solution. (24187351)
2013
18
Pronounced risk of nontraumatic osteonecrosis of the femoral head among cigarette smokers who have never used oral corticosteroids: a multicenter case-control study in Japan. (22927108)
2012
19
Bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. (22962894)
2012
20
Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel. (22578070)
2012
21
Radiographic signs of bisphosphonate-related osteonecrosis of the jaw. (23311051)
2012
22
DSA observation of hemodynamic response of femoral head with femoral neck fracture during traction: Can traction really increase the risk of osteonecrosis of the femoral head? (22773016)
2012
23
Osteonecrosis in systemic lupus erythematosus: an early, frequent, and not always symptomatic complication. (22919470)
2012
24
Widespread osteonecrosis in children with leukemia revealed by whole-body MRI. (23008023)
2012
25
Molecular profiling of oral microbiota in jawbone samples of bisphosphonate-related osteonecrosis of the jaw. (22443347)
2012
26
Anatomic factors related to bisphosphonate osteonecrosis of the jaws: a Portuguese retrospective study. (22985921)
2012
27
Risks for jaw osteonecrosis drastically increases after 2 years of bisphosphonate therapy. (22726797)
2012
28
Osteonecrosis of the jaw in a patient with advanced non-small-cell lung cancer receiving bevacizumab. (22429334)
2012
29
Teriparatide's role in the management of bisphosphonate-associated osteonecrosis of the jaw. (22407259)
2012
30
Characteristics of bisphosphonate-related osteonecrosis of the jaw after kidney transplantation. (22976726)
2012
31
Mesenchymal stem cells and bisphosphonate-related osteonecrosis of the jaw: the future? (22913278)
2012
32
Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw. (22986334)
2012
33
Bisphosphonate-associated osteonecrosis of the jaw: are we dealing with a localized non-traditional calciphylaxis? (22276079)
2012
34
Bisphosphonate-related osteonecrosis of the jaw in patients with oral bisphosphonate exposure: clinical course and outcomes. (22595135)
2012
35
Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw. (22647765)
2012
36
Evolution of bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma and Waldenstrom's macroglobulinemia: a retrospective multicentric study. (22829257)
2012
37
Low plasma adiponectin as a potential biomarker for osteonecrosis of the femoral head. (20682678)
2010
38
Osteonecrosis and panniculitis as life-threatening signs. (20060063)
2010
39
Association of polymorphisms in the Interleukin 23 receptor gene with osteonecrosis of femoral head in Korean population. (18779654)
2008
40
Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. (18695356)
2008
41
Reduced serum levels of Interleukin 17 in patients with osteonecrosis of the jaw and in multiple myeloma subjects after bisphosphonates administration. (18585926)
2008
42
Actinomycosis of the jaws--histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis. (17952459)
2007
43
Femoral and humeral head osteonecrosis in a patient with hypofibrinolysis and hyperhomocysteinemia. A case report and a review of the literature]. (15470526)
2004
44
Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients. (12438962)
2002
45
Dysbaric osteonecrosis in Turkish sponge divers. (11908699)
2001
46
Factor V Leiden and other hypercoagulable state mutations are not associated with osteonecrosis during or after treatment for pediatric malignancy. (10064667)
1999
47
Association of osteonecrosis in systemic lupus erythematosus with abnormalities of fibrinolysis. (9493148)
1998
48
Dysbaric osteonecrosis. (1859573)
1991
49
Laminar periostitis and multiple osteonecrosis in systemic lupus erythematosus. (2088652)
1990
50
Radiology of Dysbaric osteonecrosis. (4648523)
1972

Genetic Variations for Osteonecrosis

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Expression for genes affiliated with Osteonecrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteonecrosis

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Pathways for genes affiliated with Osteonecrosis

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53Reactome
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Pathways related to Osteonecrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4DEFB4A, DEFB103B, DEFB1

Compounds for genes affiliated with Osteonecrosis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Osteonecrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hbd24410.5DEFB4A, DEFB103B, DEFB1
2ticlopidine44 1111.5CYP2C8, APOH
3progesterone44 59 28 11 2414.4APOH, PROK1, DEFB103B, DEFB4A, DKK1, CYP2C8
4ethanol44 49 11 2413.3APOH, CYP2C8, ACP5, ALPPL2
5dexamethasone44 49 28 1113.1ACP5, CYP2C8, DEFB4A, DEFB103B, DEFB1

GO Terms for genes affiliated with Osteonecrosis

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16Gene Ontology
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Molecular functions related to Osteonecrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:00449710.4CYP27C1, CYP2C8

Products for genes affiliated with Osteonecrosis

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Sources for Osteonecrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet