MCID: OST002
MIFTS: 77

Osteoporosis malady

Bone diseases category

Summaries for Osteoporosis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Osteoporosis makes your bones weak and more likely to break. anyone can develop osteoporosis, but it is common in older women. as many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis. risk factors include getting older being small and thin having a family history of osteoporosis taking certain medicines being a white or asian woman having osteopenia, which is low bone density osteoporosis is a silent disease. you might not know you have it until you break a bone. a bone mineral density test is the best way to check your bone health. to keep bones strong, eat a diet rich in calcium and vitamin d, exercise and do not smoke. if needed, medicines can also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoporosis is related to idiopathic juvenile osteoporosis and arthritis. An important gene associated with Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Signaling by GPCR and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs medium chain triglycerides and cholecalciferol and the compounds vitamin d and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A bone resorption disease that has material basis in a drop in estrogen or testosterone which results in the thinning of bone tissue and loss of bone mineral density.

Wikipedia:63 Osteoporosis (\"porous bones\", from Greek: οστούν/ostoun meaning \"bone\" and πόρος/poros... more...

Description from OMIM:46 166710

Aliases & Classifications for Osteoporosis

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoporosis 8 20 22 46 10 44 33 60


External Ids:

Disease Ontology8 DOID:11476
ICD9CM27 733.0, 733.00
MeSH34 D010024
NCIt39 C3298

Related Diseases for Osteoporosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoporosis family:

Juvenile Primary Osteoporosis

Diseases related to Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 444)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic juvenile osteoporosis30.9COL1A1, LRP5, IGF1, CALCA
2arthritis30.7ALOX15, VDR, TNFRSF11B, TNFSF11, CALCA, ALOX5
3rheumatoid arthritis30.6TNFSF11, TNFRSF11B, ALOX15, ALOX5, CD36
4osteoarthritis30.6COL1A2, COL1A1, LRP5, ALOX5, CD36, VDR
5breast cancer30.5PTH, CALCA, CALCR, WNT1, VDR, IGF1
6osteomalacia30.5CD36, TNFRSF11B, CALCA, PTH, KL, VDR
7prostatitis30.5VDR
8obesity30.4ALOX5, IGF1
9prostate cancer30.4IGF1, VDR, TNFSF11, WNT1
10periodontitis30.4TNFSF11, TNFRSF11B, VDR, CD36
11hyperparathyroidism30.4CALCA, TNFSF11, TNFRSF11B, VDR, PTH, KL
12diabetes mellitus30.3VDR, CALCA, LRP5, PTH, CD36, IGF1
13amenorrhea30.3IGF1
14periodontal disease30.3CD36, TNFRSF11B, TNFSF11
15osteogenesis imperfecta30.3CD36, LRP5, COL1A1, COL1A2
16osteoporosis, postmenopausal30.2COL1A1, CALCA, TNFSF11, TNFRSF11B, IGF1, VDR
17primary hyperparathyroidism30.2PTH, CALCA, CD36, VDR
18arthropathy30.2TNFSF11, ALOX5, TNFRSF11B
19hypogonadism30.2IGF1, CALCA
20paget's disease of bone30.2CALCA
21cushing's syndrome30.2TNFRSF11B, CALCA, IGF1
22ankylosing spondylitis30.1TNFSF11, TNFRSF11B, PTH
23connective tissue disease30.1COL1A2, COL1A1, CD36
24thyroiditis30.1CALCA
25hypercalcemia30.0VDR, TNFSF11, CALCA, PTH, TNFRSF11B, CALCR
26atherosclerosis30.0ALOX15, ALOX5, CD36, IGF1, TNFRSF11B
27hypertension30.0PTH, IGF1, CALCA
28anorexia nervosa30.0TNFRSF11B, IGF1
29vascular disease30.0ESR1
30osteosclerosis29.9TNFRSF11B, LRP5, TNFSF11, PTH
31otosclerosis29.9COL1A2, COL1A1, TNFRSF11B, CD36
32adenoma29.9PTH, IGF1, CALCA, VDR
33cystic fibrosis29.9TNFRSF11B, COL1A2, SLC9A3R1
34nephrolithiasis29.9PTH, SLC34A1, VDR
35osteopetrosis29.9TNFRSF11B, TNFSF11, LRP5
36gingivitis29.9TNFRSF11B, TNFSF11
37leukemia29.8ALOX5, CALCR, VDR
38bone carcinoma29.8TNFSF11, TNFRSF11B, CD36
39asthma29.8VDR, ALOX5, ALOX15
40turner syndrome29.8IGF1
41galactosemia29.8IGF1
42secondary syphilis29.6TNFRSF11B, CALCA, VDR, CD36, LRP5, PTH
43hypophosphatemia29.6VDR, PTH, SLC34A1, CALCA, KL
44myeloma29.6TNFSF11, IGF1, TNFRSF11B, CALCR, CD36
45paget disease, juvenile29.6CALCA, TNFSF11, TNFRSF11B
46rickets29.6PTH, VDR, CD36
47hyperostosis29.6COL1A1, LRP5
48dentinogenesis imperfecta29.6COL1A2, COL1A1, CD36
49hyperthyroidism29.6PTH, IGF1
50hypothyroidism29.6IGF1, PTH

Graphical network of the top 20 diseases related to Osteoporosis:



Diseases related to osteoporosis

Clinical Features for Osteoporosis

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

166710

Clinical synopsis from OMIM:

166710

Drugs & Therapeutics for Osteoporosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Osteoporosis

Search NIH Clinical Center for Osteoporosis

Search CenterWatch for Osteoporosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Osteoporosis

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Osteoporosis:

id Genetic test Affiliating Genes
1 Osteoporosis20 22 VDR

Anatomical Context for Osteoporosis

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32MalaCards
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MalaCards organs/tissues related to Osteoporosis:

32
Bone, Testes, Skin, Breast, Prostate, Bone marrow, Heart, Liver, Endothelial, Thyroid, Kidney, Monocytes, T cells, Whole blood, Tongue, Spinal cord, Lung, Adipocyte, Pineal, Skeletal muscle, B cells, Brain, Uterus, Pituitary

Animal Models for Osteoporosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteoporosis:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7KL, COL1A2, COL1A1, CALCA, CALCR, TNFSF11
2MP:000539712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
3MP:000538712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
4MP:000538512.2KL, COL1A2, COL1A1, CALCA, TNFRSF11B, IGF1
5MP:000537612.2KL, COL1A1, CALCA, CALCR, TNFSF11, IGF1
6MP:000538412.0KL, COL1A2, COL1A1, TNFSF11, TNFRSF11B, IGF1
7MP:000539012.0ALOX5, KL, COL1A2, CALCR, TNFSF11, TNFRSF11B
8MP:000537812.0TNFRSF11B, TNFSF11, COL1A1, COL1A2, KL, IGF1
9MP:000538611.9KL, COL1A2, COL1A1, CALCA, VDR, CD36
10MP:000536911.5KL, COL1A2, IGF1, VDR, CD36, SLC34A1
11MP:001077111.2COL1A1, CALCA, TNFSF11, VDR, ALOX15
12MP:000538211.1COL1A1, TNFSF11, TNFRSF11B, VDR, WNT1, LRP5
13MP:000537111.1KL, COL1A2, LRP5
14MP:000538911.1KL, COL1A1, VDR, SLC34A1, ALOX15
15MP:000537911.0KL, VDR
16MP:000536710.9SLC34A1, SLC9A3R1, KL
17MP:000363110.9SLC9A3R1, VDR, COL1A1, KL
18MP:000537710.6TNFRSF11B
19MP:000537510.5KL, COL1A1, ALOX5

Publications for Osteoporosis

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50PubMed
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Articles related to Osteoporosis:

(show top 50)    (show all 2144)
idTitleAuthorsYear
1
Osteoporosis of the Bone--At Sea without a Lifeboat. (24379316)
2014
2
Empirically Based Composite Fracture Prediction Model from the Global Longitudinal Study of Osteoporosis in Postmenopausal Women (GLOW). (24423345)
2014
3
Comparative cost-effectiveness of bazedoxifene and raloxifene in the treatment of postmenopausal osteoporosis in Europe, using the FRAX algorithm. (24114398)
2014
4
The quantitative diagnostic capability of routine MR imaging and diffusion-weighted imaging in osteoporosis patients. (23849102)
2013
5
Genetic basis of osteoporosis; looking for trabecular and cortical BMD variants. (24422095)
2013
6
Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis. (22707062)
2013
7
Black tea may be a prospective adjunct for calcium supplementation to prevent early menopausal bone loss in a rat model of osteoporosis. (23984184)
2013
8
A 22-year-old man with severe osteoporosis due to prolactinoma. (23965473)
2013
9
Bone disorders: Targeting NOX4 knocks down osteoporosis. (24287775)
2013
10
Epidemiology of Osteoporosis and Osteoporotic Fractures in South Korea. (24396660)
2013
11
Homocysteine, an additional factor, is linked to osteoporosis in postmenopausal women with type 2 diabetes. (24366622)
2013
12
High circulating sclerostin is present in patients with thalassemia-associated osteoporosis and correlates with bone mineral density. (22581647)
2012
13
Risk factors for osteoporosis in long-term survivors of intracranial germ cell tumors. (22057549)
2012
14
Osteoporosis and RANKL signal]. (21814019)
2011
15
Severe osteoporosis treated with teriparatide in a patient affected by recessive epidermolysis bullosa dystrophica. (20458569)
2011
16
Osteoporosis in Klinefelter's syndrome. (20348548)
2010
17
Emerging treatments for postmenopausal osteoporosis - focus on denosumab. (19554095)
2009
18
Urolithiasis and osteoporosis: clinical relevance and therapeutic implications. (20120412)
2009
19
Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study. (18284942)
2008
20
Bisphosphonate therapy for women with breast cancer and at high risk for osteoporosis. (17304967)
2007
21
Biochemical markers of bone turnover may predict progression to osteoporosis in osteopenic women: the JPOS Cohort Study. (17323182)
2007
22
Effect of the Women's Health Initiative on osteoporosis therapy and expenditure in Medicaid. (16734392)
2006
23
Antipsychotic drugs: a new risk factor for osteoporosis in young women with schizophrenia? (15643097)
2005
24
Once-weekly alendronate 70 mg and raloxifene 60 mg daily in the treatment of postmenopausal osteoporosis. (15243278)
2004
25
Calcitonin therapy in osteoporosis. (15743107)
2004
26
Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes. (12608943)
2003
27
Predictors of bone mineral density and osteoporosis in patients attending a rheumatology outpatient clinic. (12634938)
2003
28
The effects of alendronate and calcitonin on cytokines in postmenopausal osteoporosis: a 6-month randomized and controlled study. (12619182)
2003
29
Diagnosis and treatment of osteoporosis in patients with vertebral compression fractures. (12657067)
2003
30
Potential use of HMG-CoA reductase inhibitors for osteoporosis. (11918519)
2002
31
Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. (12162999)
2002
32
Hydroxymethylglutaryl-coenzyme A reductase inhibitors in osteoporosis management. (11847956)
2002
33
Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. (11846330)
2001
34
Advances in the treatment of osteoporosis. (12476784)
2001
35
Preventing and treating osteoporosis: strategies at the millennium. (11795353)
2001
36
The diagnosis and management of osteoporosis. (10769435)
2000
37
Osteoporosis prevention, detection, and treatment. A mandate for primary care physicians. (10887444)
2000
38
Association of transforming growth factor beta1 genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis. (10750555)
2000
39
Sex steroids, biochemical markers, bone mineral density and histomorphometry in male osteoporosis patients. (11125545)
2000
40
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
41
Alteration of the circadian rhythm of intact parathyroid hormone and serum phosphate in women with established postmenopausal osteoporosis. (9666934)
1998
42
Multicenter comparative study of synthetic salmon calcitonin administered nasally in the treatment of established postmenopausal osteoporosis]. (7718710)
1995
43
Clinical usefulness of biochemical markers of bone remodeling in osteoporosis]. (7792532)
1995
44
Arginine supplementation in the prevention and treatment of osteoporosis. (7877530)
1994
45
Impaired bone formation in male idiopathic osteoporosis: further reduction in the presence of concomitant hypercalciuria. (1627899)
1992
46
Calcitonin metabolism in senile (type II) osteoporosis. (1627901)
1992
47
Multiple fractures in a child: the osteoporosis pseudoglioma syndrome. A case report. (1400555)
1992
48
Treatment of osteoporosis and Paget's disease. (1883692)
1991
49
The importance of urinary hydroxyproline and serumal osteocalcin in the evaluation of post-menopausal osteoporosis. (2099937)
1990
50
Idiopathic juvenile osteoporosis. (474538)
1979

Genetic Variations for Osteoporosis

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Osteoporosis:

62
id Symbol AA change Variation ID SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Expression for genes affiliated with Osteoporosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporosis

Search GEO for disease gene expression data for Osteoporosis.

Pathways for genes affiliated with Osteoporosis

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Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
See all sources

Pathways related to Osteoporosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5PTH, WNT1, IGF1, CALCR, CALCA, COL1A1
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
11.4VDR, TNFSF11, TNFRSF11B, IGF1, CALCA, PTH
3
Hide members
11.2LRP5, COL1A2, WNT1, COL1A1, IGF1, TNFSF11
4
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
11.0VDR, COL1A2, COL1A1, TNFSF11, PTH
510.9PTH, COL1A1, TNFSF11, TNFRSF11B
610.8COL1A2, ESR1, VDR
710.8COL1A2, COL1A1, ALOX15
810.8KL, ESR1, VDR
910.8COL1A2, COL1A1, CD36
1010.8CD36, COL1A2, COL1A1
11
Cell adhesion ECM remodeling
Hide members
10.8COL1A2, COL1A1, IGF1
12
Hide members
10.8TNFRSF11B, TNFSF11, CALCR
1310.7COL1A1, COL1A2
1410.7COL1A1, COL1A2
1510.7COL1A1, COL1A2
1610.7CALCA, CALCR
17
Hide members
10.7ALOX5, ALOX15
18
Hide members
10.7ALOX5, ALOX15

Compounds for genes affiliated with Osteoporosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1vitamin d4412.5ESR1, CALCA, ALOX5, PTH, SLC34A1, LRP5
2calcium44 49 11 2415.4COL1A2, PTH, SLC34A1, SLC9A3R1, ALOX5, TNFRSF11B
31,25 dihydroxy vitamin d34412.0LRP5, SLC34A1, VDR, TNFRSF11B, TNFSF11, CALCR
4calcitriol44 59 11 2415.0TNFSF11, TNFRSF11B, IGF1, VDR, CD36, SLC34A1
5vegf4412.0TNFSF11, TNFRSF11B, IGF1, CD36, PTH, ESR1
6alendronate44 49 1113.8CALCA, TNFSF11, TNFRSF11B, ESR1, CD36, VDR
725-hydroxyvitamin d4411.7TNFRSF11B, VDR, TNFSF11, CALCA, CD36, PTH
8raloxifene44 28 49 1114.7TNFSF11, IGF1, CD36, VDR, TNFRSF11B, CALCA
9dexamethasone44 49 28 1114.6ALOX5, COL1A1, CALCR, TNFSF11, TNFRSF11B, VDR
10tyrosine4411.6KL, SLC9A3R1, PTH, TNFRSF11B, WNT1, COL1A2
11creatinine4411.6CALCR, TNFSF11, TNFRSF11B, VDR, CD36, PTH
12genistein44 28 59 2 11 2416.6ALOX5, VDR, TNFRSF11B, ESR1, CD36, TNFSF11
13deoxypyridinoline4411.6TNFRSF11B, VDR, TNFSF11, CALCA, PTH, CD36
14phosphorus4411.6VDR, TNFSF11, CALCA, TNFRSF11B, PTH, SLC34A1
15testosterone44 59 11 2414.5TNFSF11, VDR, CALCA, ESR1, TNFRSF11B, IGF1
16sb 20358044 5912.5TNFSF11, IGF1, VDR, ALOX5, CD36, TNFRSF11B
17teriparatide44 1112.5CD36, TNFRSF11B, TNFSF11, CALCA, ESR1
18ly2940024411.5IGF1, TNFRSF11B, TNFSF11, COL1A2, ESR1, CD36
19ibandronate44 1112.5CALCA, ESR1, CD36, TNFRSF11B, TNFSF11
20pamidronate44 49 1113.4CALCA, TNFSF11, TNFRSF11B, CD36, PTH
21risedronate44 59 49 28 1115.4TNFSF11, TNFRSF11B, CALCA, ESR1, CD36
22clodronate44 49 1113.4TNFRSF11B, TNFSF11, CD36, CALCA, VDR
23hydroxyproline44 11 2413.4TNFRSF11B, COL1A1, CALCA, CD36, PTH
24aspartate4411.4COL1A1, TNFRSF11B, VDR, SLC9A3R1, ALOX5, COL1A2
25thyroxine44 2412.3PTH, VDR, IGF1, TNFRSF11B, CALCA
26tartrate4411.3CD36, TNFSF11, CALCA, CALCR
27vitamin k24411.3CALCA, TNFSF11, TNFRSF11B, CD36
28xbai4411.3VDR, COL1A2, COL1A1, ESR1
29pyridinoline4411.3TNFRSF11B, CALCA, IGF1, CD36
30serine4411.3VDR, TNFRSF11B, TNFSF11, COL1A2, ALOX5
31zoledronic acid4411.3CALCA, TNFSF11, TNFRSF11B, CD36
32ascorbic acid44 2412.2TNFSF11, ALOX5, TNFRSF11B, VDR, CD36
33dhea4411.2CALCR, TNFSF11, TNFRSF11B, IGF1
34tamoxifen44 49 28 1114.2ESR1, TNFRSF11B, IGF1, VDR, PTH
35denosumab44 1112.2TNFRSF11B, CALCA, TNFSF11
36etidronate4411.1TNFRSF11B, CD36, CALCA
37procollagen4411.1COL1A2, TNFSF11
38calcium carbonate4411.1CD36, PTH, CALCA
39forskolin44 49 1113.1PTH, CALCA, CALCR
40estrogen4411.0VDR
41pmma4411.0TNFRSF11B, TNFSF11, CALCA
42pge24411.0COL1A1
43cycloheximide4411.0PTH
44retinoic acid44 2411.9WNT1, CD36, VDR, IGF1, TNFRSF11B, COL1A1
45hydrocortisone44 2 59 1113.9IGF1, CD36, TNFRSF11B, CALCA
46estradiol44 11 2412.9CALCR
47titanium4410.9TNFSF11, TNFRSF11B, CD36
48hcc-14410.8TNFRSF11B, TNFSF11
49eb 108944 5911.7ESR1, VDR, IGF1
5015hpete4410.7ALOX5, ALOX15

GO Terms for genes affiliated with Osteoporosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6CALCR, IGF1, CD36, WNT1, LRP5, SLC9A3R1
2extracellular spaceGO:00561511.5TNFSF11, WNT1, IGF1, TNFRSF11B, PTH, CALCA
3extracellular regionGO:00557611.4PTH, TNFRSF11B, WNT1, KL, COL1A2, COL1A1
4collagen type IGO:00558410.4COL1A2, COL1A1

Biological processes related to Osteoporosis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.6TNFSF11, IGF1, VDR, WNT1, LRP5, PTH
2skeletal system developmentGO:00150111.5PTH, VDR, IGF1, TNFRSF11B, COL1A1, COL1A2
3platelet activationGO:03016811.2COL1A2, COL1A1, IGF1, CD36
4positive regulation of cAMP biosynthetic processGO:03081911.1PTH, CALCR, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.1CALCA, CALCR, PTH
6positive regulation of fibroblast proliferationGO:04814611.1ESR1, WNT1, IGF1
7regulation of blood pressureGO:00821711.1LRP5, CALCA, COL1A2
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.0TNFSF11, WNT1, ESR1
9mammary gland branching involved in pregnancyGO:06074511.0VDR, ESR1
10positive regulation of adenylate cyclase activityGO:04576211.0CALCR, CALCA
11skin morphogenesisGO:04358911.0COL1A2, COL1A1
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:06052711.0ESR1, IGF1
13response to magnesium ionGO:03202611.0SLC34A1, TNFRSF11B
14negative regulation of bone resorptionGO:04577910.9TNFRSF11B, CALCA
15protein heterotrimerizationGO:07020810.9COL1A1, COL1A2
16positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, WNT1
17apoptotic cell clearanceGO:04327710.8CD36, ALOX15
18lipoxygenase pathwayGO:01937210.8ALOX5, ALOX15
19elevation of cytosolic calcium ion concentrationGO:00720410.8CALCA, CALCR, ESR1
20negative regulation of cell-substrate adhesionGO:01081210.8WNT1, COL1A1
21mammary gland alveolus developmentGO:06074910.7ESR1, TNFSF11
22positive regulation of glycogen biosynthetic processGO:04572510.6PTH, IGF1
23bone remodelingGO:04684910.4SLC34A1, LRP5

Molecular functions related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7COL1A1, COL1A2
2hormone activityGO:00517910.6PTH, IGF1, CALCA, KL

Products for genes affiliated with Osteoporosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoporosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet