MCID: OST002
MIFTS: 73

Osteoporosis malady

Bone category

Summaries for Osteoporosis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Osteoporosis makes your bones weak and more likely to break. anyone can develop osteoporosis, but it is common in older women. as many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis. risk factors include getting older being small and thin having a family history of osteoporosis taking certain medicines being a white or asian woman having osteopenia, which is low bone density osteoporosis is a silent disease. you might not know you have it until you break a bone. a bone mineral density test is the best way to check your bone health. to keep bones strong, eat a diet rich in calcium and vitamin d, exercise and do not smoke. if needed, medicines can also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoporosis is related to osteoporosis, postmenopausal and idiopathic juvenile osteoporosis. An important gene associated with Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Signaling by GPCR and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs cholecalciferol and fluorides and the compounds vitamin d and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A bone resorption disease that has material basis in a drop in estrogen or testosterone which results in the thinning of bone tissue and loss of bone mineral density.

Wikipedia:64 Osteoporosis (\"porous bones\", from Greek: οστούν/ostoun meaning \"bone\" and πόρος/poros... more...

Description from OMIM:47 166710

Aliases & Classifications for Osteoporosis

Sources:
8Disease Ontology, 20GeneTests, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

osteoporosis 8 20 22 47 10 45 34 61


External Ids:

Disease Ontology8 DOID:11476
ICD9CM27 733.0, 733.00
MeSH35 D010024
NCIt40 C3298

Related Diseases for Osteoporosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoporosis family:

juvenile primary osteoporosis

Diseases related to Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 433)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis, postmenopausal31.6COL1A1, CALCA, TNFSF11, TNFRSF11B, IGF1, VDR
2idiopathic juvenile osteoporosis31.0COL1A1, LRP5, IGF1, CALCA
3arthritis30.8ALOX15, VDR, TNFRSF11B, TNFSF11, CALCA, ALOX5
4osteoarthritis30.6COL1A2, COL1A1, LRP5, ALOX5, CD36, VDR
5osteomalacia30.5CD36, TNFRSF11B, CALCA, PTH, KL, VDR
6amenorrhea30.4IGF1
7osteogenesis imperfecta30.3CD36, LRP5, COL1A1, COL1A2
8primary hyperparathyroidism30.2PTH, CALCA, CD36, VDR
9arthropathy30.2TNFSF11, ALOX5, TNFRSF11B
10cushing's syndrome30.2TNFRSF11B, CALCA, IGF1
11ankylosing spondylitis30.1TNFSF11, TNFRSF11B, PTH
12hypercalcemia30.1VDR, TNFSF11, CALCA, PTH, TNFRSF11B, CALCR
13atherosclerosis30.1ALOX15, ALOX5, CD36, IGF1, TNFRSF11B
14anorexia nervosa30.1TNFRSF11B, IGF1
15vascular disease30.1ESR1
16otosclerosis30.0COL1A2, COL1A1, TNFRSF11B, CD36
17adenoma30.0PTH, IGF1, CALCA, VDR
18cystic fibrosis30.0TNFRSF11B, COL1A2, SLC9A3R1
19nephrolithiasis30.0PTH, SLC34A1, VDR
20osteopetrosis30.0TNFRSF11B, TNFSF11, LRP5
21rheumatic disease30.0TNFSF11, TNFRSF11B, ALOX5
22bone carcinoma29.8TNFSF11, TNFRSF11B, CD36
23asthma29.8VDR, ALOX5, ALOX15
24turner syndrome29.8IGF1
25hepatitis b29.8VDR
26secondary syphilis29.6TNFRSF11B, CALCA, VDR, CD36, LRP5, PTH
27hypophosphatemia29.6VDR, PTH, SLC34A1, CALCA, KL
28paget disease, juvenile29.6CALCA, TNFSF11, TNFRSF11B
29rickets29.6PTH, VDR, CD36
30dentinogenesis imperfecta29.6COL1A2, COL1A1, CD36
31hypoparathyroidism29.6PTH, CALCA
32osteogenesis imperfecta type i29.6COL1A2, COL1A1
33blindness29.6LRP5
34marfan syndrome29.6COL1A2, CD36
35insulin resistance29.6IGF1
36graves' disease29.6VDR
37coronary heart disease29.6ALOX5
38growth hormone deficiency29.6IGF1
39acromegaly29.6IGF1
40x-linked hypophosphatemia29.6SLC34A1, VDR
41osteitis fibrosa29.6PTH
42metabolic acidosis29.6PTH, IGF1
43bone fracture10.6
44osteoporosis-pseudoglioma syndrome10.6
45mastocytosis10.4
46osteoporotic fracture10.4
47systemic mastocytosis10.4
48thalassemia10.4
49hajdu-cheney syndrome10.3
50osteonecrosis10.3

Graphical network of the top 20 diseases related to Osteoporosis:



Diseases related to osteoporosis

Clinical Features for Osteoporosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

166710

Clinical synopsis from OMIM:

166710

Drugs & Therapeutics for Osteoporosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Osteoporosis

Search NIH Clinical Center for Osteoporosis

Search CenterWatch for Osteoporosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Osteoporosis

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Osteoporosis:

id Genetic test Affiliating Genes
1 Osteoporosis20 22 VDR

Anatomical Context for Osteoporosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Osteoporosis:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lung, Uterus, Bone marrow, Whole blood, Heart, Skeletal muscle, Adipocyte, Thyroid, Adrenal gland, Breast, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Pituitary

Animal Models for Osteoporosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Osteoporosis:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7KL, COL1A2, COL1A1, CALCA, CALCR, TNFSF11
2MP:000539712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
3MP:000538712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
4MP:000538512.2KL, COL1A2, COL1A1, CALCA, TNFRSF11B, IGF1
5MP:000537612.2KL, COL1A1, CALCA, CALCR, TNFSF11, IGF1
6MP:000538412.0KL, COL1A2, COL1A1, TNFSF11, TNFRSF11B, IGF1
7MP:000539012.0ALOX5, KL, COL1A2, CALCR, TNFSF11, TNFRSF11B
8MP:000537812.0TNFRSF11B, TNFSF11, COL1A1, COL1A2, KL, IGF1
9MP:000538611.9KL, COL1A2, COL1A1, CALCA, VDR, CD36
10MP:000536911.5KL, COL1A2, IGF1, VDR, CD36, SLC34A1
11MP:001077111.2COL1A1, CALCA, TNFSF11, VDR, ALOX15
12MP:000538211.1COL1A1, TNFSF11, TNFRSF11B, VDR, WNT1, LRP5
13MP:000537111.1KL, COL1A2, LRP5
14MP:000538911.1KL, COL1A1, VDR, SLC34A1, ALOX15
15MP:000537911.0KL, VDR
16MP:000536710.9SLC34A1, SLC9A3R1, KL
17MP:000363110.9SLC9A3R1, VDR, COL1A1, KL
18MP:000537710.6TNFRSF11B
19MP:000537510.5KL, COL1A1, ALOX5

Publications for Osteoporosis

Sources:
51PubMed
See all sources

Articles related to Osteoporosis:

(show top 50)    (show all 2146)
idTitleAuthorsYear
1
Total and Appendicular Lean Mass Reference Ranges for Australian Men and Women: The Geelong Osteoporosis Study. (24390582)
2014
2
Renal safety in patients treated with bisphosphonates for osteoporosis: a review. (23907861)
2013
3
Similar relationship between the time course of bone mineral density improvement and vertebral fracture risk reduction with denosumab treatment in postmenopausal osteoporosis and prostate cancer patients on androgen deprivation therapy. (24214315)
2013
4
HIF1I+ is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. (24023068)
2013
5
Massive calcinosis and severe osteoporosis in paediatric-onset overlap syndrome. (24238236)
2013
6
Osteonecrosis of the jaw after osteoporosis therapy with denosumab following long-term bisphosphonate therapy. (23541016)
2013
7
Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. (24089220)
2013
8
Frailty and osteoporosis in older women-a prospective study. (24002542)
2013
9
Development of the osteoporosis assessment questionnaire-physical function (OPAQ-PF): an osteoporosis-targeted, patient-reported outcomes (PRO) measure of physical function. (23929004)
2013
10
Osteobiography of a 19th century elderly woman with pertrochanteric fracture and osteoporosis: a multidisciplinary approach. (24308247)
2013
11
Rethinking osteoporosis: balancing risk and benefit in diagnosis, prevention, and treatment. (24049936)
2013
12
Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case-control study in the CPRD. (24322476)
2013
13
Nephrotic syndrome after oral bisphosphonate (alendronate) administration in a patient with osteoporosis. (22278748)
2012
14
Polymorphisms in xenobiotic-metabolizing genes in the pathogenesis of glucocorticoid-induced osteoporosis in patients with bronchial asthma]. (22642106)
2012
15
Primary hyperparathyroidism associated with vitamin D toxicity in a patient with severe osteoporosis receiving teriparatide. (23087890)
2012
16
A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India. (20663622)
2010
17
Calvarial doughnut lesions and osteoporosis: a new three-generation family and review. (19839042)
2009
18
Effect of risedronate on biochemical marker of bone resorption in postmenopausal women with osteoporosis or osteopenia. (18382907)
2008
19
Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis. (18687167)
2008
20
Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires. (19197451)
2008
21
Denosumab: an investigational drug for the management of postmenopausal osteoporosis. (19707445)
2008
22
Management of age-related osteoporosis and prevention of associated fractures. (18360603)
2006
23
Update of current therapeutic options for the treatment of postmenopausal osteoporosis. (16678639)
2006
24
Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). (16133640)
2005
25
Vitamin D receptor genotypes influence the success of calcitriol therapy for recurrent vertebral fracture in osteoporosis. (15861036)
2005
26
Raloxifene (Evista) in the treatment of postmenopausal osteoporosis--the profile of the patient]. (16689133)
2005
27
Effects of the Cdx-2 polymorphism of the vitamin D receptor gene and lifestyle factors on bone mineral density in a representative sample of Japanese women: the Japanese Population-based Osteoporosis (JPOS) Study. (16362455)
2005
28
Therapeutic effects of calcitonin on back pain in the patients with osteoporosis]. (15741698)
2005
29
Obesity and osteoporosis]. (15912326)
2005
30
Changes in serum receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). (15240611)
2004
31
Association of vitamin D receptor polymorphisms with osteoporosis in mexican postmenopausal women. (14527203)
2003
32
Are statins of value in therapy of osteoporosis?]. (12879634)
2003
33
Risk of fracture and treatment to prevent osteoporosis-related fracture in postmenopausal women. A review. (12856513)
2003
34
Aging bone and osteoporosis: strategies for preventing fractures in the elderly. (14557222)
2003
35
Osteoporosis: a review. (11816351)
2002
36
Statins and osteoporosis: can these lipid-lowering drugs also bolster bones? (11996199)
2002
37
Osteoporosis, bone turnover and hypogonadism in elderly men with treated leprosy. (11715278)
2001
38
Osteoporosis: evaluation and treatment. (10984823)
2000
39
Management of corticosteroid-induced osteoporosis. (10707991)
2000
40
Prevention of corticosteroid-induced osteoporosis by alfacalcidol. (10769437)
2000
41
Collagen type Ialpha1 gene polymorphism in idiopathic osteoporosis in men. (11085801)
2000
42
Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b. (8605279)
1996
43
Osteoporosis and lactose intolerance. (8817761)
1996
44
Type I collagen biosynthesis by skin fibroblasts from patients with idiopathic juvenile osteoporosis. (7671570)
1995
45
Usefulness of biochemical markers of bone turnover in diagnosis of osteoporosis]. (8058983)
1994
46
Osteoporosis-pseudoglioma syndrome. (8418655)
1993
47
Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture. (1616331)
1992
48
Risk for developing osteoporosis in untreated premature menopause. (1393775)
1992
49
Lysinuric protein intolerance: a rare cause of childhood osteoporosis. (3083306)
1986
50
Congenital cutis laxa and osteoporosis. (6846273)
1983

Genetic Variations for Osteoporosis

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Osteoporosis:

63
id Symbol AA change Variation SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Expression for genes affiliated with Osteoporosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoporosis

Search GEO for disease gene expression data for Osteoporosis.

Pathways for genes affiliated with Osteoporosis

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB
See all sources

Pathways related to Osteoporosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5KL, COL1A2, COL1A1, CALCA, CALCR, IGF1
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
11.4PTH, COL1A1, CALCA, CALCR, TNFSF11, TNFRSF11B
3
Hide members
11.2COL1A2, COL1A1, TNFSF11, IGF1, WNT1, LRP5
4
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
11.0COL1A2, COL1A1, TNFSF11, VDR, PTH
510.9COL1A1, TNFSF11, TNFRSF11B, PTH
610.8COL1A2, VDR, ESR1
710.8ALOX15, COL1A1, COL1A2
810.8ESR1, VDR, KL
910.8COL1A2, COL1A1, CD36
1010.8CD36, COL1A1, COL1A2
11
Cell adhesion ECM remodeling
Hide members
10.8COL1A2, COL1A1, IGF1
12
Hide members
10.8TNFRSF11B, TNFSF11, CALCR
1310.7COL1A1, COL1A2
1410.7COL1A1, COL1A2
1510.7COL1A2, COL1A1
1610.7CALCR, CALCA
17
Hide members
10.7ALOX15, ALOX5
18
Hide members
10.7ALOX5, ALOX15

Compounds for genes affiliated with Osteoporosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1vitamin d4512.5IGF1, VDR, CD36, LRP5, SLC34A1, PTH
2calcium45 50 11 2415.4TNFSF11, CALCR, CALCA, COL1A1, COL1A2, KL
31,25 dihydroxy vitamin d34512.0TNFRSF11B, IGF1, VDR, LRP5, SLC34A1, PTH
4calcitriol45 60 11 2415.0CALCA, CALCR, TNFSF11, TNFRSF11B, IGF1, VDR
5vegf4512.0KL, COL1A1, CALCA, TNFSF11, TNFRSF11B, IGF1
6alendronate45 50 1113.8CALCA, TNFSF11, TNFRSF11B, IGF1, VDR, CD36
725-hydroxyvitamin d4511.7CALCA, TNFSF11, TNFRSF11B, IGF1, VDR, CD36
8raloxifene45 29 50 1114.7CALCA, TNFSF11, TNFRSF11B, IGF1, VDR, CD36
9dexamethasone45 50 29 1114.6COL1A1, CALCR, TNFSF11, TNFRSF11B, VDR, PTH
10tyrosine4511.6KL, COL1A2, CALCR, TNFSF11, TNFRSF11B, IGF1
11creatinine4511.6CALCR, TNFSF11, TNFRSF11B, IGF1, VDR, CD36
12genistein45 29 60 2 11 2416.6TNFSF11, TNFRSF11B, IGF1, VDR, CD36, ESR1
13deoxypyridinoline4511.6CALCA, TNFSF11, TNFRSF11B, VDR, CD36, PTH
14phosphorus4511.6PTH, SLC34A1, VDR, TNFRSF11B, TNFSF11, CALCA
15testosterone45 60 11 2414.5CALCA, TNFSF11, TNFRSF11B, IGF1, VDR, PTH
16sb 20358045 6012.5TNFSF11, TNFRSF11B, IGF1, VDR, CD36, ALOX5
17teriparatide45 1112.5CALCA, TNFSF11, TNFRSF11B, CD36, ESR1
18ly2940024511.5COL1A2, TNFSF11, TNFRSF11B, IGF1, CD36, ESR1
19ibandronate45 1112.5ESR1, CD36, TNFRSF11B, TNFSF11, CALCA
20pamidronate45 50 1113.4CALCA, TNFSF11, TNFRSF11B, CD36, PTH
21risedronate45 60 50 29 1115.4ESR1, CD36, TNFRSF11B, TNFSF11, CALCA
22clodronate45 50 1113.4CALCA, TNFSF11, TNFRSF11B, VDR, CD36
23hydroxyproline45 11 2413.4COL1A1, CALCA, TNFRSF11B, CD36, PTH
24aspartate4511.4COL1A2, COL1A1, TNFRSF11B, VDR, SLC9A3R1, ALOX5
25thyroxine45 2412.3CALCA, TNFRSF11B, IGF1, VDR, PTH
26vitamin k24511.3CALCA, TNFSF11, TNFRSF11B, CD36
27tartrate4511.3CALCA, CALCR, TNFSF11, CD36
28xbai4511.3COL1A2, COL1A1, VDR, ESR1
29pyridinoline4511.3CD36, IGF1, TNFRSF11B, CALCA
30serine4511.3COL1A2, TNFSF11, TNFRSF11B, VDR, ALOX5
31zoledronic acid4511.3CALCA, TNFSF11, TNFRSF11B, CD36
32ascorbic acid45 2412.2TNFSF11, TNFRSF11B, VDR, CD36, ALOX5
33dhea4511.2CALCR, TNFSF11, TNFRSF11B, IGF1
34tamoxifen45 50 29 1114.2TNFRSF11B, IGF1, VDR, PTH, ESR1
35denosumab45 1112.2TNFRSF11B, TNFSF11, CALCA
36etidronate4511.1CD36, TNFRSF11B, CALCA
37procollagen4511.1COL1A2, TNFSF11
38calcium carbonate4511.1PTH, CD36, CALCA
39forskolin45 50 1113.1PTH, CALCR, CALCA
40estrogen4511.0VDR
41pmma4511.0TNFRSF11B, TNFSF11, CALCA
42pge24511.0COL1A1
43cycloheximide4511.0PTH
44retinoic acid45 2411.9COL1A1, TNFRSF11B, IGF1, VDR, CD36, WNT1
45hydrocortisone45 2 60 1113.9CALCA, TNFRSF11B, IGF1, CD36
46estradiol45 11 2412.9CALCR
47titanium4510.9CD36, TNFRSF11B, TNFSF11
48hcc-14510.8TNFRSF11B, TNFSF11
49eb 108945 6011.7ESR1, VDR, IGF1
50doxercalciferol4510.7PTH, VDR

GO Terms for genes affiliated with Osteoporosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6CALCR, IGF1, CD36, WNT1, LRP5, SLC9A3R1
2extracellular spaceGO:00561511.5PTH, KL, COL1A2, COL1A1, CALCA, TNFSF11
3extracellular regionGO:00557611.4KL, COL1A2, COL1A1, CALCA, TNFSF11, TNFRSF11B
4collagen type IGO:00558410.4COL1A2, COL1A1

Biological processes related to Osteoporosis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.6TNFSF11, IGF1, VDR, WNT1, LRP5, PTH
2skeletal system developmentGO:00150111.5PTH, VDR, IGF1, TNFRSF11B, COL1A1, COL1A2
3platelet activationGO:03016811.2COL1A2, COL1A1, IGF1, CD36
4positive regulation of cAMP biosynthetic processGO:03081911.1PTH, CALCR, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.1CALCA, CALCR, PTH
6positive regulation of fibroblast proliferationGO:04814611.1ESR1, WNT1, IGF1
7regulation of blood pressureGO:00821711.1LRP5, CALCA, COL1A2
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.0TNFSF11, WNT1, ESR1
9mammary gland branching involved in pregnancyGO:06074511.0VDR, ESR1
10positive regulation of adenylate cyclase activityGO:04576211.0CALCR, CALCA
11skin morphogenesisGO:04358911.0COL1A2, COL1A1
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:06052711.0ESR1, IGF1
13response to magnesium ionGO:03202611.0SLC34A1, TNFRSF11B
14negative regulation of bone resorptionGO:04577910.9TNFRSF11B, CALCA
15protein heterotrimerizationGO:07020810.9COL1A1, COL1A2
16positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, WNT1
17apoptotic cell clearanceGO:04327710.8CD36, ALOX15
18lipoxygenase pathwayGO:01937210.8ALOX5, ALOX15
19elevation of cytosolic calcium ion concentrationGO:00720410.8CALCA, CALCR, ESR1
20negative regulation of cell-substrate adhesionGO:01081210.8WNT1, COL1A1
21mammary gland alveolus developmentGO:06074910.7ESR1, TNFSF11
22positive regulation of glycogen biosynthetic processGO:04572510.6PTH, IGF1
23bone remodelingGO:04684910.4SLC34A1, LRP5

Molecular functions related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7COL1A1, COL1A2
2hormone activityGO:00517910.6PTH, IGF1, CALCA, KL

Products for genes affiliated with Osteoporosis

  • Antibodies
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  • Antibodies

Sources for Osteoporosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet