MCID: OST002
MIFTS: 77

Osteoporosis malady

Bone diseases category

Summaries for Osteoporosis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Osteoporosis makes your bones weak and more likely to break. anyone can develop osteoporosis, but it is common in older women. as many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis. risk factors include getting older being small and thin having a family history of osteoporosis taking certain medicines being a white or asian woman having osteopenia, which is low bone density osteoporosis is a silent disease. you might not know you have it until you break a bone. a bone mineral density test is the best way to check your bone health. to keep bones strong, eat a diet rich in calcium and vitamin d, exercise and do not smoke. if needed, medicines can also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Osteoporosis is related to idiopathic juvenile osteoporosis and arthritis. An important gene associated with Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Signaling by GPCR and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs medium chain triglycerides and cholecalciferol and the compounds vitamin d and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are mortality/aging and hematopoietic system.

Disease Ontology:8 A bone resorption disease that has material basis in a drop in estrogen or testosterone which results in the thinning of bone tissue and loss of bone mineral density.

Wikipedia:63 Osteoporosis (\"porous bones\", from Greek: οστούν/ostoun meaning \"bone\" and πόρος/poros... more...

Description from OMIM:46 166710

Aliases & Classifications for Osteoporosis

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoporosis 8 20 22 46 10 44 33 60


External Ids:

Disease Ontology8 DOID:11476
ICD9CM27 733.0, 733.00
MeSH34 D010024
NCIt39 C3298

Related Diseases for Osteoporosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteoporosis family:

Juvenile Primary Osteoporosis

Diseases related to Osteoporosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 444)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic juvenile osteoporosis30.9COL1A1, LRP5, IGF1, CALCA
2arthritis30.7ALOX15, VDR, TNFRSF11B, TNFSF11, CALCA, ALOX5
3rheumatoid arthritis30.6TNFSF11, TNFRSF11B, ALOX15, ALOX5, CD36
4osteoarthritis30.6COL1A2, COL1A1, LRP5, ALOX5, CD36, VDR
5breast cancer30.5PTH, CALCA, CALCR, WNT1, VDR, IGF1
6osteomalacia30.5CD36, TNFRSF11B, CALCA, PTH, KL, VDR
7prostatitis30.5VDR
8obesity30.4ALOX5, IGF1
9prostate cancer30.4IGF1, VDR, TNFSF11, WNT1
10periodontitis30.4TNFSF11, TNFRSF11B, VDR, CD36
11hyperparathyroidism30.4CALCA, TNFSF11, TNFRSF11B, VDR, PTH, KL
12diabetes mellitus30.3VDR, CALCA, LRP5, PTH, CD36, IGF1
13amenorrhea30.3IGF1
14periodontal disease30.3CD36, TNFRSF11B, TNFSF11
15osteogenesis imperfecta30.3CD36, LRP5, COL1A1, COL1A2
16osteoporosis, postmenopausal30.2COL1A1, CALCA, TNFSF11, TNFRSF11B, IGF1, VDR
17primary hyperparathyroidism30.2PTH, CALCA, CD36, VDR
18arthropathy30.2TNFSF11, ALOX5, TNFRSF11B
19hypogonadism30.2IGF1, CALCA
20paget's disease of bone30.2CALCA
21cushing's syndrome30.2TNFRSF11B, CALCA, IGF1
22ankylosing spondylitis30.1TNFSF11, TNFRSF11B, PTH
23connective tissue disease30.1COL1A2, COL1A1, CD36
24thyroiditis30.1CALCA
25hypercalcemia30.0VDR, TNFSF11, CALCA, PTH, TNFRSF11B, CALCR
26atherosclerosis30.0ALOX15, ALOX5, CD36, IGF1, TNFRSF11B
27hypertension30.0PTH, IGF1, CALCA
28anorexia nervosa30.0TNFRSF11B, IGF1
29vascular disease30.0ESR1
30osteosclerosis29.9TNFRSF11B, LRP5, TNFSF11, PTH
31otosclerosis29.9COL1A2, COL1A1, TNFRSF11B, CD36
32adenoma29.9PTH, IGF1, CALCA, VDR
33cystic fibrosis29.9TNFRSF11B, COL1A2, SLC9A3R1
34nephrolithiasis29.9PTH, SLC34A1, VDR
35osteopetrosis29.9TNFRSF11B, TNFSF11, LRP5
36gingivitis29.9TNFRSF11B, TNFSF11
37leukemia29.8ALOX5, CALCR, VDR
38bone carcinoma29.8TNFSF11, TNFRSF11B, CD36
39asthma29.8VDR, ALOX5, ALOX15
40turner syndrome29.8IGF1
41galactosemia29.8IGF1
42secondary syphilis29.6TNFRSF11B, CALCA, VDR, CD36, LRP5, PTH
43hypophosphatemia29.6VDR, PTH, SLC34A1, CALCA, KL
44myeloma29.6TNFSF11, IGF1, TNFRSF11B, CALCR, CD36
45paget disease, juvenile29.6CALCA, TNFSF11, TNFRSF11B
46rickets29.6PTH, VDR, CD36
47hyperostosis29.6COL1A1, LRP5
48dentinogenesis imperfecta29.6COL1A2, COL1A1, CD36
49hyperthyroidism29.6PTH, IGF1
50hypothyroidism29.6IGF1, PTH

Graphical network of the top 20 diseases related to Osteoporosis:



Diseases related to osteoporosis

Clinical Features for Osteoporosis

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

166710

Clinical synopsis from OMIM:

166710

Drugs & Therapeutics for Osteoporosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteoporosis

Drug clinical trials:

Search ClinicalTrials for Osteoporosis

Search NIH Clinical Center for Osteoporosis

Search CenterWatch for Osteoporosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Osteoporosis

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Osteoporosis:

id Genetic test Affiliating Genes
1 Osteoporosis20 22 VDR

Anatomical Context for Osteoporosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Osteoporosis:

32
Bone, Testes, Skin, Breast, Prostate, Bone marrow, Heart, Liver, Endothelial, Thyroid, Kidney, Monocytes, T cells, Whole blood, Tongue, Spinal cord, Lung, Adipocyte, Pineal, Skeletal muscle, B cells, Brain, Uterus, Pituitary

Animal Models for Osteoporosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteoporosis:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.7KL, COL1A2, COL1A1, CALCA, CALCR, TNFSF11
2MP:000539712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
3MP:000538712.3IGF1, TNFRSF11B, TNFSF11, CALCR, COL1A1, KL
4MP:000538512.2KL, COL1A2, COL1A1, CALCA, TNFRSF11B, IGF1
5MP:000537612.2KL, COL1A1, CALCA, CALCR, TNFSF11, IGF1
6MP:000538412.0KL, COL1A2, COL1A1, TNFSF11, TNFRSF11B, IGF1
7MP:000539012.0ALOX5, KL, COL1A2, CALCR, TNFSF11, TNFRSF11B
8MP:000537812.0TNFRSF11B, TNFSF11, COL1A1, COL1A2, KL, IGF1
9MP:000538611.9KL, COL1A2, COL1A1, CALCA, VDR, CD36
10MP:000536911.5KL, COL1A2, IGF1, VDR, CD36, SLC34A1
11MP:001077111.2COL1A1, CALCA, TNFSF11, VDR, ALOX15
12MP:000538211.1COL1A1, TNFSF11, TNFRSF11B, VDR, WNT1, LRP5
13MP:000537111.1KL, COL1A2, LRP5
14MP:000538911.1KL, COL1A1, VDR, SLC34A1, ALOX15
15MP:000537911.0KL, VDR
16MP:000536710.9SLC34A1, SLC9A3R1, KL
17MP:000363110.9SLC9A3R1, VDR, COL1A1, KL
18MP:000537710.6TNFRSF11B
19MP:000537510.5KL, COL1A1, ALOX5

Publications for Osteoporosis

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Sources:
50PubMed
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Articles related to Osteoporosis:

(show top 50)    (show all 2144)
idTitleAuthorsYear
1
Current status of drug therapies for osteoporosis and the search for stem cells adapted for bone regenerative medicine. (24165804)
2014
2
The effect of short-term low-energy ultraviolet B irradiation on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis: a randomized single-blinded controlled clinical trial. (24364223)
2013
3
Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation. (23914846)
2013
4
Osteoporosis in the European Union: a compendium of country-specific reports. (24113838)
2013
5
Osteoporosis and cancer. (23877475)
2013
6
Crucial protein based drug targets and potential inhibitors for osteoporosis: new hope and possibilities. (24144207)
2013
7
The role of carnitine on ovariectomy and inflammation-induced osteoporosis in rats. (24131539)
2013
8
Synergistic antiosteoporotic effect of Lepidium sativum and alendronate in glucocorticoid-induced osteoporosis in Wistar rats. (24311835)
2013
9
Tocotrienol supplementation in postmenopausal osteoporosis: evidence from a laboratory study. (24212841)
2013
10
Systematic literature review of bisphosphonates and osteonecrosis of the jaw in patients with osteoporosis. (22784630)
2013
11
Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. (22357739)
2012
12
Role of matrix metalloproteinase-9 in the pathogenesis of osteoporosis in patients with chronic obstructive pulmonary disease]. (22994087)
2012
13
Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: a hospital-based cohort study in Japan. (22917933)
2012
14
The epidemiology of osteoporosis and fractures in ankylosing spondylitis. (22859927)
2012
15
Elevated levels of the mediator of catabolic bone remodeling RANKL in the bone marrow environment link chronic heart failure with osteoporosis. (22936827)
2012
16
Update in new anabolic therapies for osteoporosis. (20375217)
2010
17
Circulating fibroblast growth factor-23 increases following intermittent parathyroid hormone (1-34) in postmenopausal osteoporosis: association with biomarker of bone formation. (20838781)
2010
18
Denosumab--an emerging treatment for postmenopausal osteoporosis. (20095877)
2010
19
On call. I am 76 years old, and I've had an enlarged prostate for at least 10 years. I've been taking Proscar for about a year, and it seems to be helping quite a bit. I have not noticed any side effects, but I'm worried that if the medicine reduces testosterone levels enough to shrink my prostate, it will also give me osteoporosis. Should I change medications, or take Fosamax like my wife? (19434938)
2009
20
Potential new drug targets for osteoporosis. (19098925)
2009
21
Prevalence of secondary causes of bone loss among breast cancer patients with osteopenia and osteoporosis. (18955450)
2008
22
Angiotensin II accelerates osteoporosis by activating osteoclasts. (18256306)
2008
23
Heterozygous nonsense mutation SATB2 associated with cleft palate, osteoporosis, and cognitive defects. (17377962)
2007
24
Comparison of calcitonin versus calcitonin + resistance exercise as prophylaxis for osteoporosis in heart transplant recipients. (16641607)
2006
25
Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women-the Japanese Population-based Osteoporosis (JPOS) Cohort Study. (16758145)
2006
26
A clinical study of Yigu capsule in treating postmenopausal osteoporosis. (16150195)
2005
27
Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study. (15777680)
2005
28
PvuII genetic polymorphism of estrogen receptor alpha in the group of postmenopausal women with osteopenia and osteoporosis]. (16417078)
2005
29
Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures--a bone histomorphometric study. (15549637)
2005
30
Pamidronate increases bone mineral density in women with postmenopausal or steroid-induced osteoporosis. (15482386)
2004
31
Parathyroid hormone in the treatment of osteoporosis. (11707147)
2001
32
Involvement of interleukin-6 and prostaglandin E2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis. (11281165)
2001
33
Comparison of alendronate, calcitonin and calcium treatments in postmenopausal osteoporosis. (11695068)
2001
34
Absence of high-risk "s" allele associated with osteoporosis at the intronic SP1 binding-site of collagen Ialpha1 gene in Southern Chinese. (11508783)
2001
35
Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis. (10999795)
2000
36
Prevention and treatment of osteoporosis in women with breast cancer. (10943237)
2000
37
The parathyroid hormone, its fragments and analogues--potent bone-builders for treating osteoporosis. (11060744)
2000
38
Vitamin D binding protein gene in male osteoporosis: association of plasma DBP and bone mineral density with (TAAA)(n)-Alu polymorphism in DBP. (10485974)
1999
39
Post-steroidal osteoporosis]. (10375951)
1999
40
Osteoporosis pseudoglioma syndrome. (10713847)
1999
41
Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. (9284698)
1997
42
Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. (8841196)
1996
43
In vitro study of osteoblastic cells from patients with idiopathic osteoporosis and comparison with cells from non-osteoporotic controls. (8148568)
1994
44
Diagnosis and treatment of osteoporosis. (8476248)
1993
45
Senile osteoporosis--prevention and therapy]. (8465579)
1993
46
Osteoporosis in lysinuric protein intolerance. (8412005)
1993
47
Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. (1466160)
1992
48
Diagnostic significance of osteocalcin levels in the classification of senile osteoporosis]. (1559253)
1992
49
Calcitonin reserve and the differentiated response to calcitonin in osteoporosis. (2103972)
1990
50
Glucocorticoid-induced osteoporosis: pathogenesis and management. (2407167)
1990

Genetic Variations for Osteoporosis

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Osteoporosis:

62
id Symbol AA change Variation ID SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Expression for genes affiliated with Osteoporosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoporosis

Search GEO for disease gene expression data for Osteoporosis.

Pathways for genes affiliated with Osteoporosis

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Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
See all sources

Pathways related to Osteoporosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5KL, COL1A2, COL1A1, CALCA, CALCR, IGF1
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
11.4PTH, COL1A1, CALCA, CALCR, TNFSF11, TNFRSF11B
3
Hide members
11.2COL1A2, COL1A1, TNFSF11, IGF1, WNT1, LRP5
4
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
11.0COL1A2, COL1A1, TNFSF11, VDR, PTH
510.9COL1A1, TNFSF11, TNFRSF11B, PTH
610.8COL1A2, VDR, ESR1
710.8ALOX15, COL1A1, COL1A2
810.8ESR1, VDR, KL
910.8COL1A2, COL1A1, CD36
1010.8CD36, COL1A1, COL1A2
11
Cell adhesion ECM remodeling
Hide members
10.8COL1A2, COL1A1, IGF1
12
Hide members
10.8TNFRSF11B, TNFSF11, CALCR
1310.7COL1A1, COL1A2
1410.7COL1A1, COL1A2
1510.7COL1A2, COL1A1
1610.7CALCR, CALCA
17
Hide members
10.7ALOX15, ALOX5
18
Hide members
10.7ALOX5, ALOX15

Compounds for genes affiliated with Osteoporosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Osteoporosis according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1vitamin d4412.5SLC34A1, CD36, VDR, IGF1, TNFRSF11B, TNFSF11
2calcium44 49 11 2415.4PTH, SLC34A1, ALOX5, SLC9A3R1, LRP5, VDR
31,25 dihydroxy vitamin d34412.0COL1A1, CALCA, CALCR, TNFSF11, TNFRSF11B, IGF1
4calcitriol44 59 11 2415.0CALCA, CALCR, TNFSF11, TNFRSF11B, IGF1, VDR
5vegf4412.0CALCA, PTH, CD36, IGF1, TNFRSF11B, KL
6alendronate44 49 1113.8CALCA, TNFSF11, TNFRSF11B, IGF1, VDR, CD36
725-hydroxyvitamin d4411.7CALCA, TNFSF11, VDR, IGF1, CD36, PTH
8raloxifene44 28 49 1114.7ESR1, CD36, TNFSF11, VDR, IGF1, TNFRSF11B
9dexamethasone44 49 28 1114.6TNFSF11, CALCR, TNFRSF11B, PTH, ALOX5, VDR
10tyrosine4411.6SLC9A3R1, PTH, KL, WNT1, COL1A2, CALCR
11creatinine4411.6IGF1, CALCR, VDR, CD36, PTH, TNFSF11
12genistein44 28 59 2 11 2416.6TNFSF11, ESR1, CD36, VDR, IGF1, TNFRSF11B
13deoxypyridinoline4411.6CALCA, PTH, CD36, VDR, TNFRSF11B, TNFSF11
14phosphorus4411.6VDR, SLC34A1, PTH, CALCA, TNFSF11, TNFRSF11B
15testosterone44 59 11 2414.5TNFSF11, VDR, CALCA, PTH, ESR1, IGF1
16sb 20358044 5912.5CD36, VDR, ALOX5, IGF1, TNFRSF11B, TNFSF11
17teriparatide44 1112.5TNFSF11, TNFRSF11B, ESR1, CALCA, CD36
18ly2940024411.5COL1A2, TNFRSF11B, IGF1, CD36, TNFSF11, ESR1
19ibandronate44 1112.5CD36, ESR1, CALCA, TNFRSF11B, TNFSF11
20pamidronate44 49 1113.4TNFRSF11B, CALCA, PTH, CD36, TNFSF11
21risedronate44 59 49 28 1115.4ESR1, CD36, TNFSF11, CALCA, TNFRSF11B
22clodronate44 49 1113.4TNFSF11, CD36, VDR, TNFRSF11B, CALCA
23hydroxyproline44 11 2413.4COL1A1, CALCA, TNFRSF11B, CD36, PTH
24aspartate4411.4SLC9A3R1, TNFRSF11B, COL1A1, COL1A2, VDR, ALOX5
25thyroxine44 2412.3IGF1, VDR, TNFRSF11B, CALCA, PTH
26tartrate4411.3CALCA, CD36, TNFSF11, CALCR
27vitamin k24411.3CD36, TNFRSF11B, TNFSF11, CALCA
28xbai4411.3VDR, COL1A1, COL1A2, ESR1
29pyridinoline4411.3TNFRSF11B, IGF1, CD36, CALCA
30serine4411.3ALOX5, VDR, TNFRSF11B, TNFSF11, COL1A2
31zoledronic acid4411.3CALCA, CD36, TNFSF11, TNFRSF11B
32ascorbic acid44 2412.2ALOX5, CD36, TNFSF11, TNFRSF11B, VDR
33dhea4411.2IGF1, TNFRSF11B, TNFSF11, CALCR
34tamoxifen44 49 28 1114.2PTH, VDR, TNFRSF11B, ESR1, IGF1
35denosumab44 1112.2CALCA, TNFSF11, TNFRSF11B
36etidronate4411.1TNFRSF11B, CD36, CALCA
37procollagen4411.1TNFSF11, COL1A2
38calcium carbonate4411.1CALCA, PTH, CD36
39forskolin44 49 1113.1PTH, CALCA, CALCR
40estrogen4411.0VDR
41pmma4411.0TNFSF11, CALCA, TNFRSF11B
42pge24411.0COL1A1
43cycloheximide4411.0PTH
44retinoic acid44 2411.9WNT1, CD36, VDR, IGF1, TNFRSF11B, COL1A1
45hydrocortisone44 2 59 1113.9CALCA, IGF1, CD36, TNFRSF11B
46estradiol44 11 2412.9CALCR
47titanium4410.9CD36, TNFRSF11B, TNFSF11
48hcc-14410.8TNFSF11, TNFRSF11B
49eb 108944 5911.7ESR1, VDR, IGF1
50doxercalciferol4410.7PTH, VDR

GO Terms for genes affiliated with Osteoporosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6CALCR, IGF1, CD36, WNT1, LRP5, SLC9A3R1
2extracellular spaceGO:00561511.5PTH, KL, COL1A2, COL1A1, CALCA, TNFSF11
3extracellular regionGO:00557611.4KL, COL1A2, COL1A1, CALCA, TNFSF11, TNFRSF11B
4collagen type IGO:00558410.4COL1A2, COL1A1

Biological processes related to Osteoporosis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.6TNFSF11, IGF1, VDR, WNT1, LRP5, PTH
2skeletal system developmentGO:00150111.5PTH, VDR, IGF1, TNFRSF11B, COL1A1, COL1A2
3platelet activationGO:03016811.2COL1A2, COL1A1, IGF1, CD36
4positive regulation of cAMP biosynthetic processGO:03081911.1PTH, CALCR, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.1CALCA, CALCR, PTH
6positive regulation of fibroblast proliferationGO:04814611.1ESR1, WNT1, IGF1
7regulation of blood pressureGO:00821711.1LRP5, CALCA, COL1A2
8positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.0TNFSF11, WNT1, ESR1
9mammary gland branching involved in pregnancyGO:06074511.0VDR, ESR1
10positive regulation of adenylate cyclase activityGO:04576211.0CALCR, CALCA
11skin morphogenesisGO:04358911.0COL1A2, COL1A1
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGO:06052711.0ESR1, IGF1
13response to magnesium ionGO:03202611.0SLC34A1, TNFRSF11B
14negative regulation of bone resorptionGO:04577910.9TNFRSF11B, CALCA
15protein heterotrimerizationGO:07020810.9COL1A1, COL1A2
16positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9IGF1, WNT1
17apoptotic cell clearanceGO:04327710.8CD36, ALOX15
18lipoxygenase pathwayGO:01937210.8ALOX5, ALOX15
19elevation of cytosolic calcium ion concentrationGO:00720410.8CALCA, CALCR, ESR1
20negative regulation of cell-substrate adhesionGO:01081210.8WNT1, COL1A1
21mammary gland alveolus developmentGO:06074910.7ESR1, TNFSF11
22positive regulation of glycogen biosynthetic processGO:04572510.6PTH, IGF1
23bone remodelingGO:04684910.4SLC34A1, LRP5

Molecular functions related to Osteoporosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.7COL1A1, COL1A2
2hormone activityGO:00517910.6PTH, IGF1, CALCA, KL

Products for genes affiliated with Osteoporosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteoporosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet