Summaries for Osteoporosis

Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Osteoporosis makes your bones weak and more likely to break. anyone can develop osteoporosis, but it is common in older women. as many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis. risk factors include getting older being small and thin having a family history of osteoporosis taking certain medicines being a white or asian woman having osteopenia, which is low bone density osteoporosis is a silent disease. you might not know you have it until you break a bone. a bone mineral density test is the best way to check your bone health. to keep bones strong, eat a diet rich in calcium and vitamin d, exercise and do not smoke. if needed, medicines can also help. nih: national institute of arthritis and musculoskeletal and skin diseases23

MalaCards: Osteoporosis is related to prostatitis and osteoporosis, postmenopausal. An important gene associated with Osteoporosis is LRP5 (low density lipoprotein receptor-related protein 5), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Transcription Role of VDR in regulation of genes involved in osteoporosis. The drugs mct and sodium fluoride pwdr [va product] and the compounds calcium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are skeleton and homeostasis/metabolism.

Disease Ontology: A bone resorption disease that has material basis in a drop in estrogen or testosterone which results in the thinning of bone tissue and loss of bone mineral density.6

Wikipedia: Osteoporosis (\"porous bones\", from Greek: οστούν/ostoun meaning \"bone\" and πόρος/poros...44 more...

OMIM: 166710

Aliases & Descriptions for Osteoporosis

Sources:
6Disease Ontology, 7diseasecard, 16GeneTests, 17Genetics Home Reference, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 2CDC, 19ICD9CM, 27NCIt, 24MeSH, 40SNOMED-CT
See all sources

Aliases & Descriptions:

osteoporosis 6 7 16 17 8 33 32 23 43

External Ids:

ICD9CM19 733.00, 733.0
NCIt27 C3298
SNOMED-CT40 64859006, 203428004, 156825006 203440004, more

Related Diseases for Osteoporosis

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to osteoporosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 975)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis38.9LRP5, KL, PDE4A, CNR1, CNR2, SFRP1
2osteoporosis, postmenopausal38.6LRP5, GC, VDR, BGLAP, CD36, IL11
3arthritis37.4LRP5, KL, PDE4A, CNR1, CNR2, SFRP1
4osteoarthritis35.1LRP5, LRP6, KL, PDE4A, CNR1, CNR2
5idiopathic juvenile osteoporosis35.0LRP5, BGLAP, CD36, CALCA, PTH, COL1A2
6osteopenia/osteoporosis34.6BGLAP, CD36, IGF1, CALCA, TNFRSF11B, TNFSF11
7osteomalacia34.4KL, GC, NBL1, VDR, BGLAP, KHDRBS3
8hyperparathyroidism34.4LRP5, KL, GC, GCM2, NBL1, SELE
9secondary syphilis34.2LRP5, GC, VDR, BMP2, BMP4, BMP7
10leukemia34.0ZNF384, LRP5, LRP6, PDE4A, CNR1, CNR2
11thalassemia33.3SELE, SERPINC1, VDR, BGLAP, LEP, MTHFR
12obesity32.8LRP5, CNR1, CNR2, VPS13B, GCG, GC
13rheumatoid arthritis32.8MTHFR, CD40, IL10, IL1B, IL1RN, IL2
14breast cancer32.7BMP6, RAP1A, IRS1, IRS2, AR, IGFBP5
15osteogenesis imperfecta32.4LRP5, BMP2, BGLAP, KHDRBS3, LEPRE1, UBXN11
16primary hyperparathyroidism32.1GCM2, VDR, BGLAP, PAX5, SCT, CD36
17paget's disease of bone32.0VDR, BGLAP, PAX5, B2M, CD36, IL1B
18beta thalassemia31.8SERPINC1, VDR, BGLAP, LEP, MTHFR, B2M
19osteopetrosis31.6LRP5, CLCN7, BGLAP, KHDRBS3, ATP4A, ATP12A
20inflammatory bowel disease31.1PDE4A, GCG, SELE, VDR, BMP7, BGLAP
21arterial calcification31.0GC, SELE, VDR, BMP2, BGLAP, LEP
22diabetes mellitus31.0LRP5, LRP6, PDE4A, CNR1, CNR2, GCG
23otosclerosis30.8BMP2, BMP4, CD36, IL6, TNFRSF11B, PTH1R
24thyroiditis30.7PDE4A, CNR2, GCG, GC, GCM2, RBP4
25hypercalciuria30.6KL, VDR, BGLAP, B2M, MIP, FGF23
26hypophosphatemia30.6KL, VDR, BGLAP, B2M, FGF23, MEPE
27cushing's syndrome30.5BGLAP, LEP, INS, IGFBP1, IGF1, GNAS
28hypertension30.4LRP5, LRP6, LRP8, KL, PDE4A, CNR1
29anorexia nervosa30.2CNR1, CNR2, GCG, LIF, BGLAP, KHDRBS3
30atherosclerosis30.2LRP5, LRP6, LRP8, KL, PDE4A, CNR1
31nephrolithiasis30.0VDR, BP50, CLCN7, BGLAP, B2M, INS
32ankylosing spondylitis29.9BGLAP, CD79A, CD40LG, MMP3, IL1R1, IL1RAPL2
33fibrosis29.8KL, PDE4A, CNR1, CNR2, GC, RBP4
34cleft palate29.7BMP2, BMP4, BMP6, MTHFR, SATB2, CD36
35primary biliary cirrhosis29.6VDR, BGLAP, SCT, CD79A, CD40LG, F2
36xanthomatosis29.6INS, APOE, CALCA, HMGCR, CYP3A4, CYP27A1
37back pain29.5VDR, CD36, MMP3, MMP9, INS, IL1A
38hypogonadism29.5PDE4A, GC, SERPINC1, BRD2, VDR, LMNA
39gaucher's disease29.4SEC14L2, VDR, BMP4, BGLAP, MTHFR, CD36
40chronic obstructive pulmonary disease29.2PDE4A, GC, LEPR, CFTR, MMP8, MMP9
41spondylitis29.2GC, VEGFA, VDR, BMP2, BMP4, BMP6
42periodontitis29.1VDR, CD36, MMP13, MMP3, MMP8, MMP9
43osteosclerosis29.0LRP5, VEGFA, BMP2, BGLAP, CD40LG, FOSL1
44blindness29.0LRP5, PDE4A, CNR1, GCG, RBP4, SELE
45turner syndrome28.9BGLAP, CGA, IGFBP1, IGFBP3, IGF1, GH1
46urolithiasis28.9VDR, AR, IL1A, IL1B, IL1RN, IL6
47acute lymphoblastic leukemia28.9SERPINC1, PAX5, LEPR, MTHFR, JUN, CDKN1C
48bronchitis28.8PDE4A, VDR, LEP, ALOX5, GNAS, GHRL
49ehlers-danlos syndrome28.8BGN, SCG5, CD36, FBN1, IGFBP1, LOX
50was-related disorders28.8KL, CNR1, VDR, LEP, B2M, CFTR

Graphical network of the top 20 diseases related to osteoporosis:



Graphical network of diseases related to osteoporosis

Clinical Features for Osteoporosis

Sources:
33OMIM
See all sources
Clinical features from OMIM: 166710

Drugs & Therapeutics for Osteoporosis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for osteoporosis

Drug clinical trials:

Search ClinicalTrials for osteoporosis

Search NIH Clinical Center for osteoporosis

Search CenterWatch for osteoporosis

Inferred drug relations via UMLS/NDF-RT:

43 28 cholecalciferol, fluoride, mct, sodium fluoride pwdr [va product]

Genetic Tests for Osteoporosis

Sources:
16GeneTests
See all sources

Genetic tests related to osteoporosis:

id Genetic test Affiliating Genes
1 Osteoporosis
clinical/research
VDR

Anatomical Context for Osteoporosis

Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to osteoporosis:

22
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Adipocyte, Kidney, Liver, Lung, Thyroid, Adrenal gland, Breast, Skin, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pineal

Phenotypes for genes affiliated with Osteoporosis

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to osteoporosis:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1skeleton phenotypeMP:000539015.9ZNF384, LRP4, LRP6, CNR1, SFRP1, GC
2homeostasis/metabolism phenotypeMP:000537615.6LRP4, LRP5, LRP6, KL, CNR1, SFRP1
3growth/size phenotypeMP:000537815.1ZNF384, LRP4, LRP6, LRP8, KL, CNR1
4mortality/agingMP:001076814.7LRP4, LRP5, LRP6, LRP8, KL, CNR1
5limbs/digits/tail phenotypeMP:000537114.5LRP4, LRP5, LRP6, KL, SFRP1, VEGFA
6immune system phenotypeMP:000538714.3LRP5, KL, PDE4A, CNR2, SFRP1, BRD2
7renal/urinary system phenotypeMP:000536713.8LRP4, LRP6, KL, GCM2, LMNA, BMP4
8endocrine/exocrine gland phenotypeMP:000537913.2ZNF384, LRP4, LRP5, KL, GCM2, BRD2
9hematopoietic system phenotypeMP:000539712.9SFRP1, BMP4, RAP1A, CLCN7, SBDS, P2RX7
10digestive/alimentary phenotypeMP:000538112.6LRP6, KL, GCG, VEGFA, VDR, LMNA
11cellular phenotypeMP:000538412.6LRP5, LRP6, LRP8, KL, CNR1, GCM2
12embryogenesis phenotypeMP:000538012.6LRP4, LRP5, LRP6, SFRP1, GCM2, SERPINC1
13craniofacial phenotypeMP:000538212.5LRP4, LRP5, LRP6, GCM2, BMP4, CLCN7
14reproductive system phenotypeMP:000538912.5ZNF384, LRP4, LRP6, LRP8, RBP4, VEGFA
15normal phenotypeMP:000287312.4LRP5, LRP6, LRP8, RBP4, NBL1, SELE
16liver/biliary system phenotypeMP:000537012.4LRP5, LRP6, SERPINC1, BRD2, VEGFA, BMP4
17integument phenotypeMP:001077112.3LRP4, LRP6, KL, CNR1, CNR2, NBL1
18nervous system phenotypeMP:000363112.3LRP4, LRP5, LRP6, LRP8, KL, PDE4A
19respiratory system phenotypeMP:000538812.0LRP4, LRP6, KL, LIF, CLCN7, SCG5
20cardiovascular system phenotypeMP:000538511.8LRP5, KL, PDE4A, SFRP1, RBP4, SELE
21behavior/neurological phenotypeMP:000538611.8LRP4, LRP5, LRP6, LRP8, KL, CNR1
22adipose tissue phenotypeMP:000537511.4LRP6, KL, CNR1, SFRP1, BRD2, LMNA
23hearing/vestibular/ear phenotypeMP:000537711.3LRP6, VDR, LMNA, BMP2, BMP4, BMP7
24no phenotypic analysisMP:000301210.9LRP6, CNR1, SFRP1, VEGFA, BMP4, LEPR
25pigmentation phenotypeMP:000118610.9LRP5, SERPINC1, LMNA, BMP7, CLCN7, ATRN
26other phenotypeMP:000539510.8KL, CNR1, LEPR, QPCT, FSHR, CD40LG
27vision/eye phenotypeMP:000539110.8LRP5, LRP6, RBP4, SELE, SERPINC1, VEGFA
28muscle phenotypeMP:000536910.4KL, RBP4, VEGFA, LMNA, BMP4, LIF
29tumorigenesisMP:00020069.9LEP, LEPR, B2M, CEBPA, FSHR, CDX2

Publications for genes affiliated with Osteoporosis

Sources:
35PubMed
See all sources

Articles related to osteoporosis:

(show top 50)    (show all 1216)
idTitleAuthorsYearAffiliating Genes
1Association of estrogen receptor-alpha gene polymorph ism with pathogenesis of osteoporosis in Korean vegetarian men. (20357503)Kim S.Y.... Kang B.Y.2010ESR1
2A microarray based identification of osteoporosis-rel ated genes in primary culture of human osteoblasts. (19781675)Trost Z.... Marc J.2010GSR, TXNRD1, AOX1
3Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study. (19373426)Velasco J.... Riancho J.A.2010LRP5, LRP6, TCF7L1
4Osteoporosis in Klinefelter's syndrome. (20348548)Ferlin A.... Foresta C.2010INSL3, IGFL3
5Is denosumab better than alendronate in the treatment of osteoporosis? (19092832)Lewiecki E.M.2009TNFSF11
6Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese. (19442614)Huang Q.Y.... Kung A.W.2009TNFRSF1B, CNR2, MTHFR
7Future developments in osteoporosis therapy. (19857200)Ng K.W.2009CTSK
8The role of osteopontin: a shared pathway in the pathogenesis of multiple sclerosis and osteoporosis? (18845306)AltintaA9 A.... Purisa S.2009SPP1
9Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major. (19352306)Pietrapertosa A.C.... D'Amore M.2009TNFRSF11B, TNFSF11
10Effects of warm needle moxibustion on bone mass density and biochemical indexes of bone metabolism in patients of postmenopausal osteoporosis (19127918)Zhao L.H.... Ye F.W.2008BGLAP
11Daily practice using the guidelines for prevention and treatment of osteoporosis. How do we realize the bone quality in routine practice using Japanese guideline for osteoporosis prevention and treatment? (18677047)Saito M.2008LOX
12Tumour necrosis factor superfamily member 11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in postmenopausal women with osteoporosis. (18502820)Mencej S.... Marc J.2008TNFSF11
13Acute changes in serum osteoprotegerin and receptor activator for nuclear factor-kappaB ligand levels in women with established osteoporosis treated with teriparatide. (18299476)Anastasilakis A.D.... Avramidis A.2008TNFRSF11B, TNFSF11
14Basic and clinical aspects of osteoporosis in inflammatory bowel disease. (18069754)RodrA-guez-Bores L.... Yamamoto-Furusho J.K.2007VDR, TNFRSF11B, CALCA
15Estrogen hydroxylation in osteoporosis. (17249385)Napoli N.... Armamento-Villareal R.2007CYP1A1
16Osteoporosis in men (17424782)Kastelan D.2007IGF1
17Pathogenesis of osteoporosis in liver cirrhosis. (17153457)Giouleme O.I.... Harsoulis F.I.2006BGLAP
18Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis? (16171525)Gur A.... Sarac A.J.2005IL2RA, CD36, IFNA1
19Estrogen receptor alpha gene analysis in osteoporosis and familial osteoporosis. (15258723)Fountas L.... Moutsatsou P.2004ESR1, ESR2
20Osteoporosis associated with inflammatory bowel diseases (15202326)Miheller P.... Tulassay Z.2004ESR1, CALCA
21Effects of different treatments for osteoporosis on prevention of fractures: toward and individualized and economic approach (15061107)Lamy O.... Krieg M.A.2004CALCA
22Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study. (15465502)Ishida Y.... Kawai S.2004CALCA
23Clinical practice guidelines for diagnosis and treatment of osteoporosis (12638216)Hayashi Y.2003CALCA
24Calcium-sensing receptor antagonists for osteoporosis (15775064)Seiji F.2003CASR
25The implication of assessing a polymorphism in estrogen receptor alpha gene in the risk assessment of osteoporosis using a screening tool for osteoporosis in Asians. (12961063)Ongphiphadhanakul B.... Rajatanavin R.2003ESR1
26What is osteoporosis? (12697910)Christodoulou C.... Cooper C.2003CALCA
27Meta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosis. (12202469)Cranney A.... Guyatt G.2002CALCA
28Current status of calcitonin use in osteopenia/osteoporosis (11599160)Hawkins Carranza F.2001CALCA
29Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis. (11274019)Woitge H.W.... Pecherstorfer M.2001BGLAP
30Alendronate: an update of its use in osteoporosis. (11434454)Sharpe M.... Spencer C.M.2001CALCA
31Consensus statement on the modern therapy of Paget's disease of bone from a Western Osteoporosis Alliance symposium. Biannual Foothi lls Meeting on Osteoporosis, Calgary, Alberta, Canada, September 9-10, 2000. (11354395)Drake W.M.... Brown J.P.2001CALCA, PAX5
32Association of a G2014A transition in exon 8 of the estrogen receptor-alpha gene with postmenopausal osteoporosis. (11846326)Ongphiphadhanakul B.... Rajatanavin R.2001ESR1
33Prevalence and determinants of osteoporosis drug pres cription among patients with high exposure to glucocorticoid drugs. (11439733)Ettinger B.... Pressman A.2001CALCA
34Osteoporosis in rheumatoid arthritis--significance of alfacalcidol in prevention and therapy (10769429)Schacht E.2000TNF, IL6, IL10
35The diagnosis and management of osteoporosis. (10769435)Baylink D.J.2000CALCA
36Study on relationship between estrogen receptor gene polymorphism and syndrome differentiation typing of female postmenopausal osteoporosis in Traditional Chinese medicine (11938861)An S.... Tong X.2000ESR1
37Osteoblast numbers after calcitonin therapy: a retrospective study of paired biopsies obtained during long-term calcitonin therapy in postmenopausal osteoporosis. (10602841)Gruber H.E.... Chesnut Ill C.H.2000CALCA
38Plasma leptin concentrations in postmenopausal women with osteoporosis. (10664526)OdabaA9i E.... Ozdemir I.C.2000LEP
39Evidence-based medicine and osteoporosis: a compariso n of fracture risk reduction data from osteoporosis randomised clinical trials. (10344048)Meunier P.J.1999CALCA
40Effect of sex hormone replacement on the insulin-like growth factor system and bone mineral: a cross-sectional and longitudinal study in 595 perimenopausal women participating in the Danish Osteoporosis Prevention Study. (10404791)Vestergaard P.... Mosekilde L.1999IGFBP3, IGF2
41Diagnosis and management of osteoporosis in postmenop ausal women: clinical guidelines. International Committee for Osteoporosis Clin ical Guidelines. (10440625)Meunier P.J.... Wasnich R.D.1999CALCA
42Studies of drug delivery systems for a therapeutic agent used in osteoporosis. I. Pharmacodynamics (hypocalcemic effect) of elcatonin in rabbits following rectal administration of hollow-type suppositories containing elcatonin. (9853410)Watanabe Y.... Matsumoto M.1998CALCA
43Current and future nonhormonal approaches to the trea tment of osteoporosis. (8829694)Bilezikian J.P.1996CALCA
44Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 9. Calcitonin in the treatment of osteoporosis. (8837547)Siminoski K.... Josse R.G.1996CALCA
45Evaluation of the preventive role of estro-progestogens and non-hormonal therapies in postmenopausal osteoporosis (8991900)Reginster J.Y.1996CALCA
46Post-pregnancy osteoporosis (7967088)Kera J.... Takeuchi S.1994CALCA
47Treatment of postmenopausal osteoporosis with salmon calcitonin nasal spray: evaluation by bone mineral content and biochemical patterns. (8370634)Tolino A.... Montemagno U.1993CALCA
48Prevention and treatment of osteoporosis. One of the most frequent disorders in American women: a review. (1293248)Ambrus J.L.... Munschauer F.E.1992CALCA
49Severe osteoporosis in a young female patient with C rohn's disease (1648471)Neef B.... von Gaisberg U.1991CALCA
50Overview of osteoporosis. (2024511)Riggs B.L.1991CALCA

Expression for genes affiliated with Osteoporosis

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Osteoporosis

Pathways for genes affiliated with Osteoporosis

Sources:
41Thomson Reuters, 10EMD Millipore, 36QIAGEN, 20KEGG, 37R&D Systems
See all sources

Pathways related to osteoporosis according to GeneDecks:

(show top 50)    (show all 197)
idPathwayScoreTop Affiliating Genes
1Transcription_Role of VDR in regulation of genes involved in osteoporosis4112.7VDR, BGLAP, CGA, JUN, CDX2, CDKN1C
2Transcription Role of VDR in regulation of genes involved in osteoporosis1012.6VDR, BGLAP, CGA, JUN, CDX2, CDKN1C
3Development Hedgehog and PTH signaling pathways in bone and cartilage development1012.1VDR, BGLAP, MMP13, FOS, IBSP, GNAS
4NF-KappaB (p50-p65) Pathway3611.9BMP2, BMP4, BMP6, BMP7, IRAK2, FGF23
5Development_Hedgehog and PTH signaling pathways in bone and cartilage development4111.8VDR, BGLAP, MMP13, FOS, IBSP, GNAS
6Akt Signaling3611.6BMP2, BMP4, BMP7, LIF, ITGB2, IRS1
7Rho Family GTPases3611.6BMP2, BMP4, BMP6, BMP7, LIF, JUN
8p38 Signaling3611.5BMP2, BMP4, BMP6, BMP7, RALA, LIF
9CREB Pathway3611.3BMP2, BMP4, BMP6, BMP7, FGF23, IL2
10Molecular Mechanisms of Cancer3611.3LRP5, LRP6, BMP2, BMP4, BMP6, BMP7
11Osteoclast differentiation2011.3JUN, FOS, FOSL1, MITF, IL1A, IL1B
12NF-KappaB Family Pathway3611.3BMP2, BMP4, BMP6, BMP7, IRAK2, FGF23
13MAPK Signaling3611.2BMP2, BMP4, BMP6, BMP7, RAP1A, JUN
14ERK Signaling3611.0BMP2, BMP4, BMP6, BMP7, RAP1A, ITGB2
15Factors Promoting Cardiogenesis in Vertebrates3611.0BMP2, FZD4, CTNNB1, NOG, TGFB1, TGFB2
16Tec Kinases Signaling3610.9BMP2, BMP4, BMP6, BMP7, ITGB2, FOS
17Telomerase Components in Cell Signaling3610.9BMP2, BMP4, BMP6, BMP7, FGF23, IL2
18Cytokine-cytokine receptor interaction2010.9VEGFA, BMP2, BMP7, LIF, LEP, LEPR
19Mitochondrial Apoptosis3610.8BMP2, BMP4, BMP6, BMP7, FGF23, IL2
20Cellular Apoptosis Pathway3610.8BMP2, BMP4, BMP6, BMP7, FGF23, IL2
21Antioxidant Action of Vitamin-C3610.8BMP2, BMP4, BMP6, BMP7, LIF, JUN
22PPAR Pathway3610.7BMP2, BMP4, ITGB2, FGF23, IL2, IL2RA
23GPCR Pathway3610.7BMP2, BMP4, BMP6, BMP7, RAP1A, RAPGEF4
24Signaling Involved in Cardiac Hypertrophy3610.7LIF, JUN, ITGB2, IRS1, IL11, IL6
25Phospholipase-C Pathway3610.6BMP2, BMP4, BMP6, BMP7, RAP1A, RALA
26TGF-Beta Pathway3610.6BMP2, BMP4, BMP6, BMP7, JUN, FOS
27Activation of PKA through GPCR3610.6GCG, BMP2, BMP4, BMP6, BMP7, RAP1A
28Rheumatoid arthritis2010.6VEGFA, JUN, ITGB2, MMP3, FOS, IL11
2914-3-3 Induced Intracellular Signaling3610.5BMP2, BMP4, BMP7, JUN, FGF23, MAPK3
30cAMP Pathway3610.5GCG, BMP2, BMP4, BMP6, BMP7, RAP1A
31Pancreatic Adenocarcinoma3610.4BMP2, BMP4, BMP6, BMP7, MMP13, MMP3
32Activation of PKC through GPCR3610.3BMP2, BMP4, BMP6, BMP7, RAP1A, ARHGEF3
33Adipocytokines & Insulin Signaling3710.2RBP4, LEP, FOS, IRS1, IRS2, INS
34PTEN Pathway3610.2BMP2, BMP4, BMP7, ITGB2, FGF23, MEPE
35MIF Regulation of Innate Immune Cells3610.2BMP2, BMP4, BMP6, BMP7, LIF, JUN
36Chagas disease (American trypanosomiasis)2010.1JUN, FOS, IL10, IL1B, IL2, IL6
37JAK-STAT Pathway3610.0BMP2, BMP4, BMP6, BMP7, JUN, FOS
38Renin-Angiotensin Pathway3610.0BMP2, BMP4, BMP6, BMP7, JUN, FOS
39Endothelin-1 Signaling Pathway3610.0BMP2, BMP4, BMP6, BMP7, IL10, IL11
40Growth Hormone Signaling369.9IRS1, MAPK3, MAPK1, IGF1R, IGF2, IGF1
41mTOR Pathway369.9BMP2, BMP4, BMP6, BMP7, IRS1, INS
42MIF Mediated Glucocorticoid Regulation369.8BMP2, BMP4, BMP6, BMP7, LIF, IL10
43Development VEGF signaling and activation109.8SELE, JUN, FOS, MAPK3, MAPK1, ICAM1
44Pathways in cancer209.7VEGFA, BMP2, BMP4, RALA, AXIN2, CEBPA
45Colorectal Cancer Metastasis369.7LRP5, LRP6, AXIN2, FZD4, MMP9, IL6
46Development VEGF signaling via VEGFR2 - generic cascades109.6VEGFA, JUN, FOS, MAPK3, MAPK1, NOS3
47p70S6K Signaling369.4BMP2, BMP4, BMP6, BMP7, IRS1, INS
48Development_VEGF signaling and activation419.4SELE, VEGFA, JUN, FOS, MAPK3, MAPK1
49Development_VEGF signaling via VEGFR2 - generic cascades419.0VEGFA, JUN, FOS, MAPK3, MAPK1, PTGS2
50Leishmaniasis208.7JUN, ITGB2, FOS, IL10, IL1A, IL1B

Compounds for genes affiliated with Osteoporosis

Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to osteoporosis according to GeneDecks:

(show top 50)    (show all 481)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 20.2LRP5, KL, PDE4A, CNR1, GCM2, RBP4
2nitric oxide32 9 18 9 17.0LRP8, PDE4A, SELE, BMP2, BMP4, BMP6
3calcitriol32 42 9 18 9 18.0GC, VDR, BMP2, BMP6, BMP7, LIF
4procollagen32 13.9BMP2, BMP6, BGLAP, PAX5, SCG5, CD36
5cysteine32 13.3LRP6, GCG, RBP4, VKORC1, VDR, BMP4
6atp32 13.1PDE4A, SEC14L2, LMNA, LIF, SCG2, SCG5
7cholesterol32 9 18 9 16.1LRP5, LRP8, CNR2, GC, RBP4, SELE
8leucine32 12.9RBP4, LMNA, BGN, SCG5, CEBPA, JUN
9estradiol32 9 18 9 15.9GC, LIF, LEPR, UGT2B17, CGA, FSHB
10dihydrotestosterone32 9 18 9 15.8VDR, BMP2, BMP6, BGLAP, LEP, UGT2B17
11alanine32 12.7CNR1, GCG, RBP4, SELE, SERPINC1, VDR
12superoxide32 18 13.5PDE4A, GC, RAP1A, LIF, SCG2, SCG5
13androstenedione32 18 13.0RBP4, LEP, LEPR, CGA, FSHR, AR
14zoledronic acid32 11.8BMP2, BGLAP, PAX5, CD36, MMP9, FDPS
15glycosaminoglycan32 11.8SERPINC1, BMP2, SCG2, SCG5, CD36, CD44
16triiodothyronine32 11.8RBP4, KHDRBS3, LEP, LEPR, CGA, IGFBP1
17glycogen32 18 12.7LRP6, SFRP1, GCG, LIF, LEPR, AXIN2
18thyroxine32 18 12.6GC, RBP4, VDR, BGLAP, SCT, LEP
19estrone32 9 18 9 14.6BGLAP, LEP, UGT2B17, IRS1, AR, IL2RA
20dopamine32 9 18 9 14.5PDE4A, GCG, RBP4, SELE, BMP2, BMP6
21mifepristone32 42 9 9 14.4LIF, CGA, JUN, MMP3, IRS1, IRS2
22nadph32 18 12.4ALDH7A1, HSD11B1, CALB1, CYP1A1, CYP1B1, CYP3A4
23diethylstilbestrol32 9 9 13.3CGA, AR, INSL3, GNRH1, ESR1, ESR2
24hydrocortisone32 9 9 13.2BMP6, LIF, BGLAP, LCT, CD36, CD40
25glycerol32 9 18 9 14.2PDE4A, GCG, SERPINC1, LEP, LCT, CFTR
26dehydroepiandrosterone sulfate32 11.2RBP4, PAX5, LEP, CGA, AR, INS
27paraffin32 11.1VEGFA, LIF, BGLAP, PAX5, SCG5, LEP
28iron32 18 12.0RBP4, BMP4, LEPRE1, B2M, MMP3, IL11
29formaldehyde32 18 11.9SELE, B2M, CFTR, CD79A, CD40LG, CD44
30azathioprine32 34 9 9 13.9BMP2, BMP4, LIF, BGLAP, MTHFR, CD79A
31bleomycin32 9 9 12.9CD44, IL2RA, IGF1, IFNA1, PTHLH, CTNNB1
32lactate32 10.8GCG, RBP4, SELE, BMP2, BMP6, LIF
33carbohydrates32 10.7SELE, LCT, CD44, IL1RN, GHR, HLA-B
34cocaine32 9 9 12.7PDE4A, CNR1, GCG, SELE, BMP6, LEP
35epinephrine32 9 18 9 13.6PDE4A, GCG, SELE, BMP6, SCT, LEP
36chloroquine32 34 9 9 13.5SERPINC1, BMP6, B2M, CFTR, CD79A, GSR
37mg 13232 42 11.4VDR, CFTR, JUN, IRS1, AR, IL1A
38pentoxifylline32 9 9 12.3PDE4A, BMP2, BMP6, ITGB2, IL10, IL18
39agar32 10.3RAP1A, RALA, CD40LG, IRS1, MIP, IL7
40rituximab32 34 9 9 13.3PAX5, CD79A, CD40LG, CD40, IL10, IL1R1
41troglitazone32 42 9 9 13.2SELE, VDR, BMP6, LEP, JUN, CD36
42methotrexate32 34 42 9 9 14.2SELE, BMP6, LEP, MTHFR, CGA, CD79A
43n acetylcysteine32 10.1SELE, SERPINC1, CFTR, CD79A, CD40, MMP3
44actinomycin d32 10.0PDE4A, SELE, VEGFA, VDR, BMP2, BMP4
45neopterin32 9.9B2M, CD79A, CD40LG, CD40, IL10, IL18
46aspirin32 34 18 11.9PDE4A, CNR1, SELE, SERPINC1, VDR, BMP6
475fluorouracil32 9.9GCG, SELE, VEGFA, VDR, LIF, MTHFR
48cytochalasin d32 42 10.5SELE, CGA, CFTR, CD36, CD44, ITGB2
49mycophenolate mofetil32 9 9 11.3SELE, CD79A, CD36, CD40LG, CD40, IL10
50okt332 9.3SELE, BMP6, CD79A, CD40LG, ITGB2, IL10

GO Terms for genes affiliated with Osteoporosis

Sources:
12Gene Ontology
See all sources

Cellular components related to osteoporosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.7EDN1, PRL, CXADR, POMC, PON1, NPPB
2extracellular spaceGO:00561511.8KL, BMP7, LIF, BGLAP, SCG2, LEP
3cytosolGO:00582911.8ACP5, THRA, DPYD, STAT3, STAT1, STK11
4plasma membraneGO:00588611.5APOE, ALPPL2, GNAS, HSP90AA1, CAT, CALCR
5cell surfaceGO:00998611.3CALR, GHR, TNF, CYP3A4, PLAT, PLAU
6proteinaceous extracellular matrixGO:00557811.1FBN1, CALR, TNFRSF11B, DMP1, SPARC, CRTAP
7integral to plasma membraneGO:00588710.4NOTCH2, PTPRD, PTH1R, TNFSF11, TNF, TRPC3
8protein complexGO:04323410.1NR3C1, AHSG, STK11, PRKAR1A, PRKCZ, PRKCA
9secretory granuleGO:0301419.6PLAT, ACPP, TF, OXT, POMC, GHRL
10external side of plasma membraneGO:0098979.5CALR, HLA-DRB1, TNF, TNFRSF11A, ACE, TGFBR2

Biological processes related to osteoporosis according to GeneDecks:

(show top 50)    (show all 62)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594413.1LRP5, LRP6, VEGFA, VDR, LMO1, BMP2
2negative regulation of transcription from RNA polymerase II promoterGO:00012212.5LRP8, VDR, LMO1, BMP2, BMP4, PAX5
3skeletal system developmentGO:00150112.5VDR, BMP2, BMP6, BMP7, BGLAP, FRZB
4negative regulation of cell proliferationGO:00828512.3SFRP1, VDR, BMP2, BMP4, LIF, LEPRE1
5ossificationGO:00150312.2BMP7, MMP8, MMP9, MGP, IGF2, IBSP
6positive regulation of transcription, DNA-dependentGO:04589312.2LRP5, LRP6, SFRP1, SEC14L2, BMP2, BMP4
7transcription initiation from RNA polymerase II promoterGO:00636711.7VDR, AR, ESR1, ESR2, ESRRA, SP1
8agingGO:00756811.7KL, CNR1, VDR, JUN, IL1B, AQP2
9female pregnancyGO:00756511.7GC, LEP, FSHB, FOSL1, IL1RN, AQP2
10osteoblast differentiationGO:00164911.7SFRP1, BMP4, BGLAP, IL18, IGFBP5, CYP24A1
11positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.5LRP6, FZD4, FOXA1, IL10, IL1B, IL6
12positive regulation of cell proliferationGO:00828411.4LRP5, SFRP1, VEGFA, LIF, LEP, CGA
13bone resorptionGO:04545311.4IL7, TRAF6, TNFSF11, PTH, PTH1R, PTK2B
14protein phosphorylationGO:00646811.3IRAK2, MAPK3, IGFBP3, CALCA, PTK2B, EIF2AK3
15small molecule metabolic processGO:04428111.3GCG, GC, RAP1A, RAPGEF4, BGN, LCT
16response to vitamin DGO:03328011.2BGLAP, IL1B, ALPL, PTGS2, CYP24A1, CYP27B1
17positive regulation of MAPK cascadeGO:04341011.1LIF, LEP, P2RX7, CD36, AR, INS
18cell-cell signalingGO:00726711.1BMP2, CGA, ITGB2, AR, INHBA, INS
19signal transductionGO:00716511.1LRP8, PDE4A, GCG, VDR, RAP1A, RALA
20cartilage developmentGO:05121611.1BMP2, BMP6, BMP7, SATB2, CD44, MAPK3
21response to mechanical stimulusGO:00961211.1BMP2, BMP4, BGLAP, P2RX7, JUN, MMP9
22positive regulation of apoptotic processGO:04306511.1LRP6, CNR1, SFRP1, BMP2, BMP4, P2RX7
23negative regulation of inflammatory responseGO:05072810.9CNR2, SERPINC1, IL2, APOE, GHRL, TNFRSF1B
24cellular response to organic cyclic compoundGO:07140710.9BMP2, CEBPA, IL18, IL1B, IGFBP5, ALPL
25positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9LRP8, VEGFA, LIF, CD36, CD44, INS
26response to glucocorticoid stimulusGO:05138410.9BGLAP, CEBPA, IL10, IL1B, IL1RN, IL6
27positive regulation of bone mineralizationGO:03050110.8KL, BMP2, BMP4, BMP6, BMP7, P2RX7
28response to estradiol stimulusGO:03235510.8GC, VDR, BMP4, MMP9, FOXA1, IL1B
29bone mineralizationGO:03028210.8BMP2, BGLAP, ZBTB40, SBDS, AXIN2, PTGS2
30anti-apoptosisGO:00691610.8CD40LG, IL10, IL1A, IL1B, IL2, APOE
31inflammatory responseGO:00695410.7CNR2, SELE, BMP2, BMP6, SCG2, P2RX7
32negative regulation of apoptotic processGO:04306610.7SFRP1, GCG, GCM2, VEGFA, BMP4, SCG2
33response to hypoxiaGO:00166610.7VEGFA, BMP2, LEP, LCT, MMP9, MECP2
34energy reserve metabolic processGO:00611210.6KL, GCG, RAP1A, RAPGEF4, LEP, LEPR
35positive regulation of NF-kappaB transcription factor activityGO:05109210.6CD40, IRAK2, AR, INS, IL1B, IL6
36response to organic cyclic compoundGO:01407010.6SFRP1, BMP4, P2RX7, ATP12A, JUN, FOSL1
37response to cytokine stimulusGO:03409710.5JUN, FOSL1, TNFRSF11A, PTGS2, CYP17A1, SPARC
38response to lipopolysaccharideGO:03249610.5CNR1, CNR2, SELE, P2RX7, JUN, MMP9
39regulation of insulin secretionGO:05079610.4CNR1, GCG, RAP1A, RAPGEF4, LEP, INS
40positive regulation of cell migrationGO:03033510.4VEGFA, BMP2, CGA, FSHB, IRS1, IRS2
41positive regulation of smooth muscle cell proliferationGO:04866110.4BMP4, JUN, IL6, IGF1, TRAF6, TNF
42lipopolysaccharide-mediated signaling pathwayGO:03166310.3IRAK2, IL18, IL1B, MAPK3, TNF, NOS3
43positive regulation of mesenchymal cell proliferationGO:00205310.3LRP5, LRP6, IRS1, IRS2, IFNG, TBX1
44response to drugGO:04249310.3PDE4A, SFRP1, BGLAP, LCT, P2RX7, B2M
45positive regulation of protein phosphorylationGO:00193410.3VEGFA, BMP2, BMP4, AXIN2, CD40, IL1B
46JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.2IRS1, IRS2, MAPK3, MAPK1, GH1, GHR
47cytokine-mediated signaling pathwayGO:01922110.1LRP8, B2M, CEBPA, CD44, FLNB, IL1A
48blood coagulationGO:0075969.4LRP8, SERPINC1, VEGFA, RAP1A, RAPGEF4, CD36
49platelet activationGO:0301689.4VEGFA, RAP1A, RAPGEF4, CD36, CD40LG, CD40
50interferon-gamma-mediated signaling pathwayGO:0603339.1B2M, CD44, IFNG, ICAM1, HLA-A, HLA-B

Molecular functions related to osteoporosis according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.3SLC12A3, SLC22A11, SLC34A1, SLPI, CSK, SOX6
2iron ion bindingGO:00550611.7CYP17A1, CYP19A1, CYP21A2, CYP27A1, CYP27B1, PLOD1
3protein homodimerization activityGO:04280311.4TERT, HMGCR, GHR, GLA, EXT2, EXT1
4cytokine activityGO:00512511.1VEGFA, BMP2, IFNG, IFNA2, FASLG, IL7
5hormone activityGO:00517911.0NPPB, GCG, KL, SCT, LEP, CGA
6growth factor activityGO:00808311.0HGF, CSF3, CSF1, DKK1, TDGF1, TGFB2
7transcription regulatory region DNA bindingGO:04421210.8NR5A2, SMAD3, SMAD4, RXRA, NFATC1, THRA
8steroid hormone receptor activityGO:00370710.6PGR, THRB, THRA, RXRA, NR5A2, NR1H2
9receptor bindingGO:00510210.3TGFB2, CRH, PTPRD, HLA-B, HLA-A, TDGF1
10protein kinase C activityGO:00469710.2PRKD3, PRKCA, PRKCQ, PRKCZ, PRKD1, PRKCI
11enzyme bindingGO:01989910.0PRKCE, STAT1, TGFB1, THRB, RXRA, PRKCH

Sources for Osteoporosis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS