Osteoporosis, Postmenopausal malady

MalaCards: Osteoporosis, Postmenopausal, also known as osteoporosis postmenopausal, is related to idiopathic juvenile osteoporosis and osteopenia/osteoporosis. An important gene associated with Osteoporosis, Postmenopausal is CALCR (calcitonin receptor), and among its related pathways are Immune System and IL-6 Pathway. The drugs mct and sodium fluoride pwdr [va product] and the compounds phosphorus and tartrate have been mentioned in the context of this disorder. Affiliated tissues include t cells and endothelial, and related mouse phenotypes are respiratory system and craniofacial.

OMIM: 166710

osteoporosis, postmenopausal 33 osteoporosis postmenopausal 32

osteoporosis 43

Diseases related to osteoporosis, postmenopausal by text searches and GeneDecks gene sharing:

(show top 50)    (show all 709)

id	Related Disease	Score	Top Affiliating Genes
1	idiopathic juvenile osteoporosis	32.6	LRP5, GC, BGLAP, IGF1, CALCA, COL1A1
2	osteopenia/osteoporosis	32.1	BGLAP, CD36, IGF1, CALCA, TNFRSF11B, TNFSF11
3	arthritis	31.5	IL1A, IL1B, IL6, TNFSF11
4	breast cancer	29.2	VDR, IL1B, IL6, ESR1, ESR2, CYP19A1
5	beta thalassemia	29.1	VDR, BGLAP, IGF1, CALCR, ESR1, TNFRSF11B
6	paget's disease of bone	28.6	BGLAP, CALCA
7	thalassemia	28.4	VDR, BGLAP, IL1B, IL6, IGF1, CALCR
8	osteomalacia	28.4	GC, VDR, BGLAP, CD36, CALCA, TNFRSF11B
9	cushing's syndrome	28.0	BGLAP, IGF1, CALCA, TNFRSF11B
10	inflammatory bowel disease	28.0	VDR, BGLAP, IL11, IL1B, IL1RAPL2, IL1RN
11	ankylosing spondylitis	27.5	BGLAP, IL1RAPL2, IL1RN, TNFRSF11B, TNFSF11, PTH
12	osteogenesis imperfecta	27.3	LRP5, BGLAP, CD36, IGF1, IBSP, COL1A1
13	multiple sclerosis	27.2	IL11, IL1A, IL1B, IL1RN, CYP27B1
14	werner syndrome	26.9	BGLAP, IL6, IGF1, GHR
15	osteopetrosis	26.8	LRP5, BGLAP, IL7, IGF1, CALCA, TNFRSF11A
16	otosclerosis	26.7	CD36, IL6, TNFRSF11B, COL1A1, COL1A2, TGFB1
17	turner syndrome	26.7	BGLAP, IGF1, GHR
18	primary hyperparathyroidism	26.6	VDR, BGLAP, PAX5, CD36, IBSP, CALCA
19	back pain	26.6	VDR, CD36, IL1A, IL1B, IL1RN, IL6
20	hypophosphatemia	26.4	VDR, BGLAP, CALCA, PTH, PTHLH, CYP27B1
21	spondylosis	26.4	VDR, IL1B, ESR1, PTH
22	osteosclerosis	26.1	LRP5, BGLAP, IL11, TNFRSF11A, TNFRSF11B, TNFSF11
23	eating disorder	26.0	BGLAP, IL1B, IGF1, GHR
24	nephrolithiasis	25.8	VDR, BGLAP, IL1B, IL1RN, CALCR, CALCA
25	neutropenia	25.3	IL11, IL1A, IL1B, IL1RN, IL6, IL7
26	gaucher's disease	25.3	VDR, BGLAP, CD36, IL6, ESR2, TNFRSF11B
27	schistosomiasis	25.0	IL1A, IL2, IL7, IGF1, TGFB1
28	chronic obstructive pulmonary disease	25.0	GC, IL6, COL1A1, TGFB1
29	type 1 diabetes mellitus	25.0	LRP5, VDR, BGLAP, IL1B, IL1RAPL2, IGF1
30	growth hormone deficiency	24.9	BGLAP, CD36, IL6, IGF1, CALCA, GHR
31	hypercalciuria	24.8	VDR, BGLAP, IL1B, IL6, CALCA, TNFSF11
32	urolithiasis	24.7	VDR, IL1A, IL1B, IL1RN, IL6, ESR1
33	crohn's disease	24.7	IL11, IL1B, IL1RAPL2, IL1RN, IL6, IL7
34	bronchitis	24.7	BGLAP, IL1B, IL6, CALCA, TGFB1, TGFB2
35	was-related disorders	24.6	VDR, IL6, IGF1, CALCA, TNFRSF11A, TNFSF11
36	vitreoretinopathy	24.6	LRP5, CD36, IL1B, IL6, TGFB1, TGFB2
37	arterial calcification	24.4	GC, VDR, BGLAP, CD36, IL6, IBSP
38	acromegaly	24.1	GC, BGLAP, CD36, IL1RAPL2, IL1RN, IL6
39	secondary syphilis	23.8	LRP5, GC, VDR, BGLAP, CD36, IL11
40	periodontitis	23.8	VDR, CD36, IL1A, IL1B, IL1RAPL2, IL1RN
41	celiac disease	23.8	VDR, BGLAP, CD36, IL1A, IL1B, IL1RN
42	leukemia/lymphoma	23.5	BGLAP, PAX5, IL2, IL6, IL7, CALCA
43	leprosy	23.5	VDR, BGLAP, IL1B, IL1RN, IL2, IL6
44	bronchial asthma	23.1	BGLAP, IL1A, IL1B, IL1RN, IL2, IL6
45	rheumatoid arthritis, association with	23.1	VDR, IL1B, IL1RN, IL6, IGF1, CTSK
46	twinning	23.1	VDR, BGLAP, PAX5, CD36, IL1A, IL6
47	retinoblastoma	22.7	VDR, PAX5, IL11, IL2, IL6, IGF1
48	anorexia nervosa	22.6	BGLAP, PAX5, CD36, IL1B, IL6, IGF1
49	spinal cord injury	22.3	GC, BGLAP, CD36, IL1B, IL2, IL6
50	hyperparathyroidism	22.2	LRP5, GC, VDR, BGLAP, PAX5, CD36

Clinical features from OMIM: 166710

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cholecalciferol, fluoride, mct, sodium fluoride pwdr [va product]

MalaCards organs/tissues related to osteoporosis, postmenopausal:

²²

MGI Mouse Phenotypes related to osteoporosis, postmenopausal:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	CALCA
2	craniofacial phenotype	MP:0005382	10.2	CTSK, PTH, LRP5
3	hematopoietic system phenotype	MP:0005397	9.7	CALCR, PTHLH, TNFRSF11A, PTH, COL1A1, CTSK
4	integument phenotype	MP:0010771	9.5	CALCA, COL1A2, COL1A1, CYP19A1, TNFRSF11A, TNFSF11
5	endocrine/exocrine gland phenotype	MP:0005379	9.5	IGFBP4, GHR, PTH, CTSK, IL2, LRP5
6	renal/urinary system phenotype	MP:0005367	8.7	GHR, PTHLH, CYP27B1, TGFB2, NOS3, ESR2
7	reproductive system phenotype	MP:0005389	8.5	TGFB1, TNFSF11, VDR, TNFRSF11A, IL1RN, IL6
8	hearing/vestibular/ear phenotype	MP:0005377	8.3	IGF1, COL1A1, CYP19A1, TNFRSF11B, ESR2, CALCA
9	liver/biliary system phenotype	MP:0005370	8.0	CD36, NOS3, CYP19A1, GHR, LRP5, IL6
10	limbs/digits/tail phenotype	MP:0005371	7.9	CTSK, LRP5, VDR, PTHLH, PTH, TNFSF11
11	nervous system phenotype	MP:0003631	7.6	GHR, PTHLH, LRP5, ESR2, CD36, CYP19A1
12	immune system phenotype	MP:0005387	7.6	LRP5, VDR, PAX5, IL2, IL6, CALCR
13	digestive/alimentary phenotype	MP:0005381	7.2	VDR, NOS3, PTHLH, ESR2, ESR1, CD36
14	mortality/aging	MP:0010768	7.1	COL1A2, PTH, TGFB2, NOS3, TNFSF11, VDR
15	skeleton phenotype	MP:0005390	6.9	TGFB2, ACP5, COL1A2, CTSK, CYP27B1, CYP19A1
16	adipose tissue phenotype	MP:0005375	6.8	COL1A1, NOS3, GHR, ESR2, ESR1, IGF1
17	muscle phenotype	MP:0005369	6.6	TGFB2, IL6, IGF1, ESR1, ESR2, CYP19A1
18	tumorigenesis	MP:0002006	6.5	TGFB1, COL1A1, IL1A, ESR2, IL1B, ESR1
19	growth/size phenotype	MP:0005378	6.1	TNFRSF11A, TNFRSF11B, TNFSF11, PTH, CYP27B1, CTSK
20	behavior/neurological phenotype	MP:0005386	5.4	ESR2, VDR, PTHLH, TNFRSF11A, GHR, ESR1
21	cellular phenotype	MP:0005384	4.5	TNFRSF11B, TNFRSF11A, ESR2, TNFSF11, PTHLH, ESR1
22	cardiovascular system phenotype	MP:0005385	4.0	CALCA, PTHLH, IL6, CYP19A1, COL1A2, TNFRSF11B
23	homeostasis/metabolism phenotype	MP:0005376	3.4	TGFB1, CALCR, IL6, TGFB2, PTHLH, TNFSF11

Articles related to osteoporosis, postmenopausal:

(show all 20)

id	Title	Authors	Year	Affiliating Genes
1	Managing osteoporosis in postmenopausal women. (20332498)	Vondracek S.F.	2010	CALCA
2	The association of IL-1beta, IL-2, and IL-6 gene poly morphisms with bone mineral density and osteoporosis in postmenopausal women. (20060205)	Czerny B.... Pawlik A.	2010	IL6, IL2, IL1B
3	Association of interleukin-1 beta (-511C/T) polymorph isms with osteoporosis in postmenopausal women. (20940514)	Chao T.H.... Wu W.T.	2010	IL1B, IL1A, IL1RN
4	Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene. (20169039)	Gennari L.... Nuti R.	2010	ESR1
5	Relationships between endothelial nitric oxide syntha se gene polymorphisms and osteoporosis in postmenopausal women. (19650200)	Liu S.Z.... Lu S.M.	2009	NOS3, CALCA, BGLAP
6	Austrian guidance for the pharmacological treatment of osteoporosis in postmenopausal women--update 2009 (19484202)	Dimai H.P.... Klaushofer K.	2009	CALCA
7	Polymorphism of osteoprotegerin gene and osteoporosi s in postmenopausal women (19548455)	Seremak-Mrozikiewicz A.... Mrozikiewicz P.M.	2009	TNFRSF11B, TNFSF11
8	Osteoporosis in postmenopausal women. Therapy options across a wide range of risk for fracture. (16405361)	Miller R.G.	2006	CALCA
9	Association of estrogen receptor alpha gene polymorphisms and lifestyle factors with calcaneal quantitative ultrasound and osteoporosis in postmenopausal Vietnamese women. (16972020)	Binh T.Q.... Nakahori Y.	2006	ESR1
10	The ALUI calcitonin receptor gene polymorphism (TT) is associated with low bone mineral density and susceptibility to osteoporosis in postmenopausal women. (12771454)	Tsai F.J.... Tsai C.H.	2003	CALCR
11	Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women (12673591)	Chen J.... Yan Z.	2003	VDR
12	Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal women in Taiwan. (11942896)	Chen H.Y.... Tsai C.H.	2002	VDR
13	Relation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. (11574953)	Chen H.Y.... Tsai C.H.	2001	BGLAP
14	Involvement of interleukin-6 and prostaglandin E2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis. (11281165)	Sugiyama T.	2001	IL6, TNFRSF11B, TNFSF11
15	Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. (11846330)	Chen H.Y.... Li C.W.	2001	VDR
16	Relation of the estrogen receptor alpha gene microsatellite polymorphism to bone mineral density and the susceptibility to osteoporosis in postmenopausal Chinese women in Taiwan. (11716992)	Chen H.Y.... Tsai C.H.	2001	ESR1
17	Comparison of alendronate and intranasal calcitonin for treatment of osteoporosis in postmenopausal women. (10843152)	Downs R.W.... Melton M.E.	2000	CALCA
18	Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone turnover rate. (9692078)	Earnshaw S.A.... Hosking D.J.	1998	PAX5
19	Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. (9783545)	Yamada Y.... Ikeda K.	1998	TGFB1
20	Aromatase in bone cell: association with osteoporosis in postmenopausal women. (7626449)	Nawata H.... Haji M.	1995	CYP19A1

Genes related to osteoporosis, postmenopausal according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	CALCR	calcitonin receptor	11.0	Publications
2	IGFBP4	insulin-like growth factor binding protein 4	11.0
3	IBSP	integrin-binding sialoprotein	11.0
4	ACP5	acid phosphatase 5, tartrate resistant	11.0
5	COL1A2	collagen, type I, alpha 2	11.0
6	PTH	parathyroid hormone	11.0
7	CTSK	cathepsin K	11.0
8	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0
9	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0
10	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
11	IL11	interleukin 11	11.0
12	IL7	interleukin 7	11.0
13	LRP5	low density lipoprotein receptor-related protein 5	11.0
14	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
15	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
16	GC	group-specific component (vitamin D binding protein)	11.0
17	COL1A1	collagen, type I, alpha 1	11.0
18	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
19	GHR	growth hormone receptor	11.0
20	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
21	PTHLH	parathyroid hormone-like hormone	11.0
22	TGFB2	transforming growth factor, beta 2	11.0
23	CD36	CD36 molecule (thrombospondin receptor)	11.0
24	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
25	ESR2	estrogen receptor 2 (ER beta)	11.0
26	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
27	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0
28	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0
29	ESR1	estrogen receptor 1	11.0	Publications
30	PAX5	paired box 5	11.0	Publications
31	IL1A	interleukin 1, alpha	11.0	Publications
32	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
33	IL1B	interleukin 1, beta	11.0	Publications
34	IL2	interleukin 2	11.0	Publications
35	TGFB1	transforming growth factor, beta 1	11.0	Publications
36	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications

Pathways related to osteoporosis, postmenopausal according to GeneDecks:

(show top 50)    (show all 83)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	10.4	GHR, CTSK
2	IL-6 Pathway36	10.3	IL11, IL7, TNFSF11
3	RAR-Gamma-RXR-Alpha Degradation36	9.9	IL7, IL11, IL2
4	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	9.9	CYP19A1, ESR1, ESR2
5	Inhibition of Angiogenesis by TSP136	9.7	TGFB2, COL1A2, COL1A1, CD36
6	PTEN Pathway36	9.7	COL1A1, IL2, COL1A2
7	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.6	TNFSF11, PTHLH, BGLAP, PTH, VDR, IBSP
8	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.6	TNFSF11, BGLAP, PTH, PTHLH, COL1A1, VDR
9	Class B/2 (Secretin family receptors)38	9.5	CALCA, CALCR, PTHLH, PTH
10	Graft-versus-host disease20	9.4	IL2, IL1A
11	NFAT Signaling and Lymphocyte Interactions36	9.4	IL2, IL7, IL1A, IL11
12	Akt Signaling36	9.0	TGFB2, TNFSF11, TNFRSF11A, IL7, IL6, IL2
13	Hematopoietic cell lineage20	8.9	IL1B, IL11, IL7, CD36, IL1A, IL6
14	PGC1Alpha Pathway36	8.9	IL7, IL2, IL1B, IL1A, IL11
15	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	TGFB2, IL1B, IL6, TGFB1
16	Cytokine Network36	8.6	IL6, IL1A, IL1B, IL2
17	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	TGFB2, TGFB1, IL6, IL1B
18	Regulation of eIF4 and p70S6K36	8.6	IL6, IL1A, IL2, IL7, IL11
19	Malaria20	8.5	CD36, TGFB2, IL1B, TGFB1, IL6
20	Amoebiasis20	8.5	TGFB2, TGFB1, COL1A2, IL6, COL1A1, IL1B
21	MIF Mediated Glucocorticoid Regulation36	8.4	TNFSF11, IL7, IL6, IL1B, IL1A, IL11
22	MIF Regulation of Innate Immune Cells36	8.4	IL2, IL11, IL1A, TNFSF11, IL7, IL1B
23	all-trans-Retinoic Acid Signaling in Brain36	8.4	IL6, IL11, TNFSF11, IL7, IL1A, IL2
24	PEDF Induced Signaling36	8.4	IL11, IL1A, IL6, TNFSF11, IL1B, IL7
25	SOCS Pathway36	8.4	IL11, IL7, IL6, IL2, IL1B, IL1A
26	STAT3 Pathway36	8.3	IL1A, IL1B, IL2, IL6, IL7, TNFRSF11A
27	Tuberculosis20	8.1	IL6, CYP27B1, VDR, TGFB1, TGFB2, IL1A
28	Osteoclast differentiation20	8.1	CALCR, TNFRSF11A, TNFRSF11B, TNFSF11, CTSK, ACP5
29	Molecular Mechanisms of Cancer36	8.0	IL11, TGFB2, TGFB1, COL1A1, TNFSF11, IL7
30	Endothelin-1 Signaling Pathway36	7.8	NOS3, IL1B, IL11, IL2, IL6, IL1A
31	Rheumatoid arthritis20	7.8	ACP5, IL11, IL1A, IL1B, TNFSF11, IL6
32	Glucocorticoid Receptor Signaling36	7.6	IL11, TGFB1, IL6, IL1B, IL7, IL2
33	DHA Signaling36	7.6	IGF1, TGFB2, TGFB1, IL6, IL1B, IL2
34	NF-KappaB (p50-p65) Pathway36	7.4	TGFB1, TGFB2, IGF1, IL6, IL2, IL1B
35	NF-KappaB Family Pathway36	7.4	IL1B, TGFB1, IGF1, IL6, IL2, IL1A
36	Transcription Role of VDR in regulation of genes involved in osteoporosis10	7.4	PTH, VDR, TNFRSF11B, BGLAP, TNFSF11, TNFRSF11A
37	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	7.4	CALCR, IGF1, IL1B, IL1A, BGLAP, VDR
38	eNOS Signaling36	7.2	IL6, NOS3, IGF1, TGFB1, ESR1, ESR2
39	Estrogen Pathway36	7.2	TGFB1, NOS3, IL2, IGF1, ESR2, IL6
40	TGF-Beta Pathway36	7.2	IGF1, TGFB2, TGFB1, IL7, IL6, IL2
41	MAPK Family Pathway36	7.2	IL1B, IL1A, TGFB1, IL2, IL11, IL7
42	MAPK Signaling36	7.1	IL6, IL1B, IL1A, IL2, TGFB2, TGFB1
43	Tec Kinases Signaling36	7.1	TNFRSF11A, TGFB1, IGF1, IL6, IL2, IL1B
44	PAK Pathway36	7.0	IL7, IL2, IL6, IGF1, TNFSF11, TGFB1
45	JAK-STAT Pathway36	7.0	TGFB1, GHR, IL7, IL6, IL2, IL1B
46	Antioxidant Action of Vitamin-C36	6.9	IL1B, IL1A, IL11, IGF1, TGFB2, IL2
47	p38 Signaling36	6.9	IL2, IL1B, IL1A, IL11, IL6, IL7
48	Cytokine-cytokine receptor interaction20	6.9	GHR, IL1B, IL11, IL1A, IL2, IL6
49	Rho Family GTPases36	6.7	IL11, IL1A, IL1B, TNFSF11, IL2, IL6
50	ERK Signaling36	6.1	IGF1, TGFB2, IL11, IL1B, IL1A, IL2

Compounds related to osteoporosis, postmenopausal according to GeneDecks:

(show top 50)    (show all 268)

id	Compound	Score	Top Affiliating Genes
1	phosphorus32	10.2	ACP5, PTH, TNFSF11, CALCA, VDR
2	tartrate32	9.4	ACP5, CTSK, PTHLH, TNFSF11, CALCA, CALCR
3	ibandronate32 9 9	11.2	CYP19A1, TNFSF11, TNFRSF11B, ESR1, CALCA, IBSP
4	hydroxyapatite32	9.2	IL11, CD36, BGLAP, IBSP, ACP5, CTSK
5	pamidronate32 9 9	11.0	BGLAP, CD36, IL6, PTHLH, PTH, TNFSF11
6	teriparatide32 9 9	11.0	TNFRSF11B, ESR1, CALCA, CD36, PAX5, BGLAP
7	risedronate32 42 9 9	11.9	CYP19A1, TNFSF11, TNFRSF11B, ESR1, CALCA, CD36
8	25-hydroxyvitamin d32	8.9	BGLAP, VDR, GC, PAX5, IGFBP4, ACP5
9	pyridinoline32	8.9	BGLAP, ACP5, PTHLH, TNFRSF11B, CALCA, IBSP
10	estradiol32 9 18 9	11.8	TNFRSF11B, CYP19A1, TGFB2, ESR2, ESR1, CALCR
11	pge232	8.7	IL1A, IL1RAPL2, TGFB2, CYP27B1, CYP19A1, TNFSF11
12	cysteine32	8.6	BGLAP, CTSK, COL1A1, ACP5, TGFB2, IBSP
13	clodronate32 9 9	10.5	ACP5, PTHLH, TNFSF11, TNFRSF11B, CALCA, IL6
14	deoxypyridinoline32	8.5	TGFB2, ACP5, VDR, BGLAP, PTH, TNFSF11
15	heparin32 9 18 9	11.2	CD36, PTHLH, TNFSF11, TNFRSF11B, IBSP, IGFBP4
16	zoledronic acid32	8.2	CTSK, CYP19A1, PTHLH, TNFSF11, TNFRSF11B, CALCA
17	alendronate32 9 9	10.2	TNFRSF11B, ESR1, CALCA, IGF1, IL11, CD36
18	hydroxyproline32 18	9.0	CD36, PAX5, BGLAP, IBSP, CALCA, TGFB1
19	sb 20358032 42	8.9	NOS3, VDR, TNFSF11, TNFRSF11B, IGF1, IL6
20	thyroxine32 18	8.8	TNFRSF11B, GHR, PTH, PTHLH, TGFB1, GC
21	forskolin32 42 9 9	10.7	IBSP, CALCA, TGFB2, CALCR, CYP27B1, PTHLH
22	prostaglandin32	7.7	TGFB2, PTHLH, PTH, TNFSF11, TNFRSF11B, TNFRSF11A
23	raloxifene32 9 9	9.6	CD36, PAX5, BGLAP, VDR, IGF1, CALCA
24	steroid32	7.5	CALCR, IBSP, IGF1, IGFBP4, IL7, IL1RAPL2
25	dihydrotestosterone32 9 18 9	10.4	IGF1, BGLAP, VDR, TGFB2, TGFB1, CYP19A1
26	creatinine32	7.4	GHR, CALCR, IBSP, IGF1, IL1RN, IL1RAPL2
27	calcium32 9 18 9	10.2	CYP27B1, PTHLH, PTH, TNFSF11, TNFRSF11B, TNFRSF11A
28	procollagen32	7.1	COL1A2, COL1A1, PTH, TNFSF11, TNFRSF11B, GHR
29	tamoxifen32 34 9 9	10.0	VDR, TGFB2, NOS3, BGLAP, IGFBP4, IGF1
30	il 1032	7.0	IL7, TGFB1, IL6, IL2, IL1RN, IL1RAPL2
31	calcitriol32 42 9 18 9	10.9	TGFB2, VDR, GC, BGLAP, PAX5, PTH
32	testosterone32 9 18 9	9.9	IGFBP4, IL7, IL1RN, IL1RAPL2, IL1A, PAX5
33	ribonucleic acid32	6.6	TGFB2, TGFB1, COL1A2, COL1A1, PTHLH, PTH
34	hydrocortisone32 9 9	8.6	IL2, IL1RN, IL1B, IL1A, CD36, BGLAP
35	rantes32	6.4	IL1A, IL11, IL1B, ACP5, TNFSF11, TNFRSF11B
36	nitric oxide32 9 18 9	9.3	CALCA, GHR, TNFSF11, PTH, PTHLH, NOS3
37	estrogen32	6.2	CD36, BGLAP, VDR, GC, LRP5, ESR2
38	cyclosporin a32 42	7.2	IL1RN, TGFB2, VDR, BGLAP, IL11, IL1A
39	1,25 dihydroxy vitamin d332	6.1	TNFRSF11A, CALCA, CALCR, IBSP, IGF1, IGFBP4
40	genistein32 9 18 9	8.9	ESR1, IGF1, IL7, IL6, IL2, IL1B
41	tyrosine32	5.7	CYP27B1, PTHLH, PTH, TNFSF11, TNFRSF11B, TNFRSF11A
42	thymidine32 18	6.7	TGFB2, TGFB1, COL1A2, COL1A1, PTHLH, IBSP
43	indomethacin32 9 9	7.6	IL1A, IL11, IL1B, CYP19A1, PTHLH, TNFSF11
44	actinomycin d32	5.4	NOS3, TGFB1, PTHLH, ESR2, ESR1, VDR
45	cycloheximide32	4.1	TGFB2, TGFB1, IL7, IL6, IL2, IL1RN
46	serine32	4.0	TGFB2, IBSP, IGF1, IGFBP4, IL7, IL2
47	dexamethasone32 42 34 9 9	7.8	ACP5, COL1A1, CYP19A1, PTHLH, PTH, TNFSF11
48	retinoic acid32 42 18	5.8	ESR1, IGF1, IGFBP4, IL7, IL6, IL1RN
49	vitamin d32	3.7	TGFB2, TGFB1, ACP5, COL1A2, COL1A1, NOS3
50	vegf32	3.5	IL2, IL1RN, IL1RAPL2, IL1B, IL1A, IL11

Cellular components related to osteoporosis, postmenopausal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen type I	GO:005584	9.9	COL1A2, COL1A1
2	neuronal cell body	GO:043025	8.8	CALCA, GHR, CYP19A1, TGFB1, TGFB2
3	extracellular region	GO:005576	4.4	IGF1, CALCA, IBSP, BGLAP, IGFBP4, IL7
4	extracellular space	GO:005615	4.3	TGFB2, IGFBP4, IL7, IL6, IL2, IL1RN

Biological processes related to osteoporosis, postmenopausal according to GeneDecks:

(show top 50)    (show all 61)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:071848	10.5	TNFRSF11A, TNFSF11
2	TNFSF11-mediated signaling pathway	GO:071847	10.5	TNFSF11, TNFRSF11A
3	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:071812	10.5	TNFSF11, TNFRSF11A
4	positive regulation of cAMP biosynthetic process	GO:030819	10.2	CALCA, PTH, CALCR, PTHLH
5	bone resorption	GO:045453	10.2	CTSK, IL7, TNFSF11, PTH, ACP5
6	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	10.2	CALCA, PTH, CALCR, PTHLH
7	cAMP metabolic process	GO:046058	10.2	PTH, PTHLH
8	positive regulation of vitamin D 24-hydroxylase activity	GO:010980	10.2	CYP27B1, VDR
9	receptor internalization	GO:031623	10.1	GHR, CALCA, CALCR
10	monocyte chemotaxis	GO:002548	9.9	TNFSF11, TNFRSF11A, IL6, CALCA
11	response to estrogen stimulus	GO:043627	9.9	CYP27B1, ESR1, BGLAP, TNFRSF11B
12	response to cytokine stimulus	GO:034097	9.8	ACP5, TNFRSF11A, TGFB2, NOS3
13	regulation of blood pressure	GO:008217	9.8	CALCA, COL1A2, LRP5, NOS3
14	organ morphogenesis	GO:009887	9.8	TNFSF11, IL7, PAX5, VDR
15	response to morphine	GO:043278	9.8	IL1B, CYP19A1, GHR
16	positive regulation of JUN kinase activity	GO:043507	9.7	IL1RN, TNFRSF11A, IL1B
17	negative regulation of release of sequestered calcium ion into cytosol	GO:051280	9.7	TGFB1, TGFB2
18	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.7	IGF1, GHR, IL2
19	positive regulation of MAPK cascade	GO:043410	9.6	IGFBP4, CD36, IL11, IGF1, IL6
20	chronic inflammatory response to antigenic stimulus	GO:002439	9.6	IL1RN, IL1B
21	positive regulation of epithelial to mesenchymal transition	GO:010718	9.5	COL1A1, TGFB1, TGFB2
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	IL11, GHR, IGF1, CD36, IL6
23	face morphogenesis	GO:060325	9.5	TGFB2, COL1A1, TGFB1
24	positive regulation of mitosis	GO:045840	9.5	LRP5, IL1A, IL1B, IGF1
25	response to organic nitrogen	GO:010243	9.4	IL1RN, IL1B, IL1A, TGFB2
26	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.4	IL1A, TNFSF11, TNFRSF11A, IL1B, CD36
27	skeletal system development	GO:001501	9.3	VDR, COL1A2, IGFBP4, IGF1, TNFRSF11B, PTH
28	fever generation	GO:001660	9.2	IL1A, IL1B
29	positive regulation of interleukin-6 production	GO:032755	9.2	IL1B, IL6, IL1A, CD36
30	female pregnancy	GO:007565	9.2	TGFB2, PTHLH, GC, IL1RN, TGFB1
31	platelet degranulation	GO:002576	9.1	TGFB2, TGFB1, IGF1, CD36
32	response to glucocorticoid stimulus	GO:051384	9.1	GHR, BGLAP, IL1B, IL1RN, CALCR, IL6
33	positive regulation vascular endothelial growth factor production	GO:010575	9.1	IL1B, IL1A, TGFB1
34	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	IL6, IL1B, TNFRSF11A, ESR1, ESR2, TNFSF11
35	response to vitamin D	GO:033280	8.9	IL1B, BGLAP, CYP27B1, TGFB1, TGFB2
36	positive regulation of cell division	GO:051781	8.9	TGFB1, IL1B, IL1A, TGFB2
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.8	TNFSF11, TGFB1, TNFRSF11A, IL6, IL1B
38	lipopolysaccharide-mediated signaling pathway	GO:031663	8.8	TGFB1, NOS3, IL1B
39	aging	GO:007568	8.5	TGFB1, TGFB2, NOS3, CALCA, IL1B, VDR
40	response to drug	GO:042493	8.4	CYP19A1, BGLAP, IL1RN, TNFRSF11B, NOS3, TGFB1
41	platelet activation	GO:030168	8.4	CD36, IL11, IL6, IGF1, COL1A2, TGFB1
42	blood coagulation	GO:007596	8.4	COL1A2, IGF1, COL1A1, NOS3, TGFB2, CD36
43	inflammatory response	GO:006954	8.3	IGFBP4, CALCA, IL6, IL1B, IL1A, TGFB1
44	cell-cell signaling	GO:007267	8.3	IL11, IL1B, IL2, IL7, CALCA, TNFRSF11A
45	response to hypoxia	GO:001666	8.3	IL1A, TGFB2, TGFB1, NOS3, IL1B
46	anti-apoptosis	GO:006916	8.1	IL1A, IL2, IGF1, NOS3, IL1B
47	response to estradiol stimulus	GO:032355	7.7	NOS3, VDR, IL1B, ESR1, GHR, TGFB1
48	positive regulation of cell proliferation	GO:008284	7.6	IGF1, IL11, IL6, TGFB2, TGFB1, TNFRSF11A
49	negative regulation of cell proliferation	GO:008285	7.1	IL6, IL1B, VDR, TGFB1, PTHLH, CYP27B1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.3	TNFSF11, LRP5, VDR, PAX5, IGF1, TGFB1

Molecular functions related to osteoporosis, postmenopausal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	estrogen response element binding	GO:034056	9.9	ESR1, ESR2
2	estrogen receptor activity	GO:030284	9.6	ESR1, ESR2
3	hormone activity	GO:005179	9.5	PTHLH, PTH, CALCA, IGF1
4	interleukin-1 receptor binding	GO:005149	9.3	IL1RN, IL1A, IL1B
5	cytokine activity	GO:005125	7.7	IL11, TGFB2, TNFSF11, TNFRSF11B, IL7, IL6
6	growth factor activity	GO:008083	7.3	IL2, IL1B, IL11, IL7, IGF1, TGFB1