MCID: OST081
MIFTS: 47

Osteoporosis, Postmenopausal malady

Bone category

Summaries for Osteoporosis, Postmenopausal

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47OMIM, 33MalaCards
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MalaCards: Osteoporosis, Postmenopausal, also known as osteoporosis postmenopausal, is related to osteoporosis and osteoporosis, postmenopausal, susceptibility. An important gene associated with Osteoporosis, Postmenopausal is COL1A2 (collagen, type I, alpha 2), and among its related pathways are Calcitonin-like ligand receptors and Interleukin-11 Signaling Pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and liver, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Description from OMIM:47 166710

Aliases & Classifications for Osteoporosis, Postmenopausal

Sources:
47OMIM, 45Novoseek, 25ICD10
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Related Diseases for Osteoporosis, Postmenopausal

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Osteoporosis, Postmenopausal via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.8COL1A2, GC, BGLAP, IBSP, CYP27B1, VDR
2osteoporosis, postmenopausal, susceptibility10.2
3thyroiditis10.0CALCA
4obesity10.0CTSK
5polycystic ovary syndrome10.0IGFBP4
6prostatitis10.0VDR
7pancreatitis10.0IL11
8chondrosarcoma10.0CTSK
9anorexia nervosa10.0TNFRSF11B
10hypervitaminosis d10.0CYP27B1
11myelofibrosis10.0IL11
12osteonecrosis10.0BGLAP
13myocardial infarction10.0IL11
14blindness10.0LRP5
15sarcoma10.0VDR
16multiple myeloma10.0TNFRSF11B, TNFSF11
17root resorption10.0TNFRSF11B, CTSK
18dermatomyositis10.0IL1RN
19acromegaly10.0BGLAP
20gingivitis10.0TNFSF11, TNFRSF11B
21hepatitis c10.0IL7
22bronchiolitis10.0IL11
23vascular disease10.0IL1RN
24hypertension10.0PTH, CALCA
25acute myocardial infarction10.0TNFSF11
26liver cirrhosis10.0IL11
27hepatitis b10.0VDR
28hypogonadism10.0BGLAP, CALCA
29nephrolithiasis10.0PTH, VDR
30hypothyroidism10.0PTH, IGFBP4
31severe combined immunodeficiency10.0IL7
32osteitis fibrosa10.0PTH, BGLAP
33williams syndrome10.0VDR, CYP27B1
34alopecia10.0VDR
35giant cell reparative granuloma10.0CALCA, CALCR, TNFRSF11A
36addison's disease10.0CYP27B1
37vitamin d-dependent rickets type ii10.0VDR, CYP27B1
38polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11B, TNFSF11, TNFRSF11A
39ischemia10.0TNFRSF11B, TGFB2
40kindler syndrome10.0BGLAP, CTSK
41aortic valve stenosis10.0TNFRSF11B, TNFSF11, IBSP
42hyperostosis10.0BGLAP, LRP5
43rickets, vitamin d-resistant, type iia10.0VDR, CYP27B1
44paget's disease of bone10.0BGLAP, CALCA
45fibrous dysplasia10.0BGLAP, IBSP
46camurati-engelmann disease10.0BGLAP, LRP5
47diabetic retinopathy10.0TGFB2
48nephrotic syndrome10.0GC
49adenoameloblastoma10.0TNFRSF11B, TNFSF11, IBSP
50osteopetrosis autosomal dominant type 210.0BGLAP, TNFSF11

Graphical network of the top 20 diseases related to Osteoporosis, Postmenopausal:



Diseases related to osteoporosis, postmenopausal

Clinical Features for Osteoporosis, Postmenopausal

Sources:
47OMIM
See all sources

Clinical features from OMIM:

166710

Drugs & Therapeutics for Osteoporosis, Postmenopausal

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Osteoporosis, Postmenopausal

Search CenterWatch for Osteoporosis, Postmenopausal

Genetic Tests for Osteoporosis, Postmenopausal

Anatomical Context for Osteoporosis, Postmenopausal

Sources:
33MalaCards
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MalaCards organs/tissues related to Osteoporosis, Postmenopausal:

33
Bone marrow, Whole blood, Liver, Breast, Uterus, Prostate, B cells, Endothelial, Pineal

Animal Models for Osteoporosis, Postmenopausal or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Osteoporosis, Postmenopausal

Sources:
51PubMed
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Articles related to Osteoporosis, Postmenopausal:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Obesity, Health-Care Utilization, and Health-Related Quality of Life After Fracture in Postmenopausal Women: Global Longitudinal Study of Osteoporosis in Women (GLOW). (24077896)
2013
2
The relationship between fibroblast growth factor 23 and osteoporosis in postmenopausal women. (24101107)
2013
3
Postmenopausal osteoporosis. (24150190)
2013
4
Discontinuation and reinitiation patterns of osteoporosis treatment among commercially insured postmenopausal women. (24235846)
2013
5
Osteoporosis in postmenopausal women: considerations in prevention and treatment: (women's health series). (24305532)
2013
6
Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24A weeks in postmenopausal women with osteoporosis. (24108429)
2013
7
Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. (22357739)
2012
8
Does autonomic dysfunction exist in postmenopausal osteoporosis? (22019965)
2011
9
The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. (20060205)
2010
10
Search for hidden secondary causes in postmenopausal women with osteoporosis. (19593233)
2010
11
Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women. (19650200)
2009
12
Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective. (19049341)
2009
13
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis. (19857095)
2009
14
Effect of risedronate on biochemical marker of bone resorption in postmenopausal women with osteoporosis or osteopenia. (18382907)
2008
15
Head-to-head comparison of risedronate vs. teriparatide on bone turnover markers in women with postmenopausal osteoporosis: a randomised trial. (18422590)
2008
16
Effects of warm needle moxibustion on bone mass density and biochemical indexes of bone metabolism in patients of postmenopausal osteoporosis]. (19127918)
2008
17
Treatment and prevention practices in postmenopausal women after bone mineral density screening at a community-based osteoporosis project. (16912337)
2006
18
Effectiveness of intranasal salmon calcitonin treatment in postmenopausal osteoporosis]. (15908722)
2005
19
Levonorgestrel and 17beta-estradiol given transdermally for the prevention of postmenopausal osteoporosis. (15653003)
2005
20
Early changes in urinary cross-linked N-terminal telopeptides of type I collagen level correlate with 1-year response of lumbar bone mineral density to alendronate in postmenopausal Japanese women with osteoporosis. (15838627)
2005
21
A specific haplotype in the 3' end of estrogen-receptor alpha gene is associated with low bone mineral density in premenopausal women and increased risk of postmenopausal osteoporosis. (15647972)
2005
22
Review of treatment modalities for postmenopausal osteoporosis. (16295815)
2005
23
Comparison of cyclic and continuous calcitonin regimens in the treatment of postmenopausal osteoporosis. (15660234)
2005
24
Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women. (16015262)
2005
25
Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study. (15465502)
2004
26
A comprehensive review of treatments for postmenopausal osteoporosis. (12577179)
2003
27
Circulating osteoprotegerin and leptin levels in postmenopausal women with and without osteoporosis. (15526523)
2003
28
The effects of alendronate and calcitonin on cytokines in postmenopausal osteoporosis: a 6-month randomized and controlled study. (12619182)
2003
29
Age-related changes in cortical bone content of insulin-like growth factor binding protein (IGFBP)-3, IGFBP-5, osteoprotegerin, and calcium in postmenopausal osteoporosis: a cross-sectional study. (12629078)
2003
30
Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. (14529146)
2003
31
Osteoprotegerin/RANKL/RANK system and postmenopausal osteoporosis. The possible therapeutic aspects]. (12916277)
2003
32
Inverse relation between osteoporosis and spondylosis in postmenopausal women as evaluated by bone mineral density and semiquantitative scoring of spinal degeneration. (12616163)
2003
33
Two polymorphisms in the vitamin D receptor gene--association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish Osteoporosis Prevention Study. (12162507)
2002
34
The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and a new effect of calcitonin. (11810415)
2002
35
Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. (11846330)
2001
36
Effects of the combined use of calcitonin and 1 alpha-hydroxycholecalciferol on vertebral bone loss and bone turnover in women with postmenopausal osteopenia and osteoporosis: a prospective study of long-term and continuous administration with low dose calcitonin. (11731184)
2001
37
Comparison of alendronate, calcitonin and calcium treatments in postmenopausal osteoporosis. (11695068)
2001
38
A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. PROOF Study Group. (10996576)
2000
39
Osteoblast numbers after calcitonin therapy: a retrospective study of paired biopsies obtained during long-term calcitonin therapy in postmenopausal osteoporosis. (10602841)
2000
40
Comparison of alendronate and intranasal calcitonin for treatment of osteoporosis in postmenopausal women. (10843152)
2000
41
Postmenopausal osteoporosis in women]. (10389480)
1999
42
Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone turnover rate. (9692078)
1998
43
Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. (9783545)
1998
44
New biochemical markers of bone resorption in the study of postmenopausal osteoporosis. (9385464)
1997
45
Parathyroid hormone and related peptides for the treatment of postmenopausal osteoporosis. (15989633)
1997
46
Cyclical pamidronate infusions in postmenopausal osteoporosis. (8887311)
1996
47
Human marrow stromal osteoblast-like cells do not show reduced responsiveness to in vitro stimulation with growth hormone in patients with postmenopausal osteoporosis. (8118745)
1994
48
Rectal salmon calcitonin for the treatment of postmenopausal osteoporosis. (1422962)
1992
49
Postmenopausal osteoporosis--definition, pathogenesis, prevention and therapy]. (1792568)
1991
50
Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers]. (2104101)
1990

Genetic Variations for Osteoporosis, Postmenopausal

Expression for genes affiliated with Osteoporosis, Postmenopausal

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporosis, Postmenopausal

Search GEO for disease gene expression data for Osteoporosis, Postmenopausal.

Pathways for genes affiliated with Osteoporosis, Postmenopausal

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG
See all sources

Pathways related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CALCR, CALCA
210.0IL11, IBSP, BGLAP
310.0PTH, TNFRSF11B, TNFSF11, IBSP
4
Vitamin D2 (ergocalciferol) metabolism
Hide members
9.9GC, VDR, CYP27B1, PTH
5
Hide members
9.9TNFRSF11A, TNFSF11, IL11, IL7
69.8TNFRSF11A, TNFSF11, TNFRSF11B, CTSK, ACP5
79.8TNFRSF11A, TNFSF11, CTSK, IL11, ACP5
8
Hide members
9.7CALCR, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK, ACP5
9
Hide members
9.7TNFSF11, IL11, IL7, TGFB2, TNFRSF11A
10
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
9.6COL1A2, BGLAP, IBSP, TNFSF11, VDR, PTH
11
Hide members
9.6COL1A2, TNFRSF11A, TNFSF11, IL11, IL7, LRP5
129.6CALCR, TNFRSF11A, TNFSF11, TNFRSF11B, CTSK, ACP5
13
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.5PTH, CALCR, TNFRSF11A, TNFSF11, TNFRSF11B, VDR

Compounds for genes affiliated with Osteoporosis, Postmenopausal

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7VDR
2cycloheximide4510.5IBSP, PTH
3procollagen4510.5TNFSF11, COL1A2, ACP5
4raloxifene45 29 50 1113.3CALCA, TNFRSF11B, TNFSF11, TNFRSF11A
5rantes4510.2IL7, ACP5, IL11, CALCR
6clodronate45 50 1112.2TNFRSF11B, CALCA, TNFSF11, ACP5, VDR
7denosumab45 1111.2TNFRSF11B, CALCA, TNFRSF11A, TNFSF11
8strontium ranelate4510.2CALCA, TNFSF11, CTSK, IBSP
9estradiol45 11 2412.2IBSP, CALCR, IGFBP4, ACP5, TGFB2
10teriparatide45 1111.2BGLAP, CALCA, TNFSF11, CTSK, TNFRSF11B
11ibandronate45 1111.2IBSP, BGLAP, TNFRSF11B, TNFSF11, CALCA
12pamidronate45 50 1112.1PTH, BGLAP, CALCA, TNFSF11, TNFRSF11B
13alfacalcidol45 60 1112.1CYP27B1, CALCA, VDR, BGLAP, GC
14tartrate4510.1CTSK, CALCR, BGLAP, ACP5, CALCA, TNFSF11
15pyridinoline4510.1IBSP, BGLAP, TNFRSF11B, ACP5, CALCA
16hydrocortisone45 2 60 1113.0BGLAP, CALCA, TNFRSF11B
17polyethylene4510.0TNFSF11, TNFRSF11B, CTSK, TNFRSF11A
18zoledronic acid4510.0IBSP, TNFRSF11B, TNFSF11, BGLAP, CALCA, CTSK
19forskolin45 50 1112.0IBSP, IL11, CALCA, CALCR, IGFBP4, PTH
20titanium4510.0ACP5, IL11, TNFRSF11B, BGLAP, IBSP, TNFSF11
2124,25-dihydroxyvitamin d34510.0CALCA, BGLAP, CYP27B1, VDR
22hydroxyproline45 11 2412.0BGLAP, CALCA, TNFRSF11B, ACP5, PTH, IBSP
23alendronate45 50 1111.8IL11, PTH, CALCA, BGLAP, TNFSF11, TNFRSF11B
24hydroxyapatite459.8ACP5, BGLAP, IBSP, IL11, CTSK, TNFRSF11B
25infliximab45 50 1111.7BGLAP, TNFSF11, TNFRSF11B, IL11, IL1RN
26thyroxine45 2410.7IGFBP4, TNFRSF11B, BGLAP, VDR, PTH, CALCA
27phosphorus459.6CYP27B1, VDR, TNFRSF11B, TNFSF11, CALCA, BGLAP
28prostaglandin459.6TNFRSF11A, TNFSF11, TNFRSF11B, IL1RN, PTH, TGFB2
29serine459.5COL1A2, BGLAP, VDR, IGFBP4, IL1RN, CTSK
30deoxypyridinoline459.5BGLAP, IBSP, CALCA, TNFSF11, TNFRSF11B, VDR
3125-hydroxyvitamin d459.4PTH, IGFBP4, TNFRSF11B, TNFSF11, CALCA, BGLAP
32heparin45 29 11 2412.4IBSP, TNFSF11, TNFRSF11B, IL7, IL1RN, IL11
33cyclic amp45 2410.3TNFSF11, PTH, IGFBP4, CYP27B1, CALCR, CALCA
34creatinine459.3GC, BGLAP, IBSP, CALCR, TGFB2, PTH
35ascorbic acid45 2410.3IBSP, TNFRSF11B, VDR, IL1RN, TGFB2, TNFSF11
36phosphatidylinositol459.3TGFB2, IL7, IL1RN, IL11, TNFRSF11B, TNFSF11
37dexamethasone45 50 29 1112.3BGLAP, CALCR, TNFSF11, IGFBP4, VDR, IL7
38cyclosporin a45 29 6011.3IL1RN, ACP5, VDR, IL11, TNFSF11, TGFB2
39steroid459.2VDR, IGFBP4, TNFRSF11B, TNFSF11, IL11, TGFB2
40nitric oxide45 11 2411.2TGFB2, CALCA, IL1RN, PTH, TNFRSF11A, TNFSF11
41cysteine459.1COL1A2, TGFB2, IBSP, TNFSF11, CTSK, IGFBP4
42testosterone45 60 11 2412.0CALCA, TNFSF11, BGLAP, TNFRSF11B, IGFBP4, VDR
43vegf459.0TNFRSF11A, CALCA, PTH, BGLAP, TNFSF11, TNFRSF11B
44calcitriol45 60 11 2412.0GC, VDR, TGFB2, BGLAP, CALCA, CALCR
45retinoic acid45 2410.0IGFBP4, IL7, IL1RN, IL11, CYP27B1, CTSK
46thymidine45 249.9COL1A2, IBSP, PTH, TGFB2, IL11, VDR
47tyrosine458.9CYP27B1, IL11, IL1RN, CALCR, IL7, ACP5
48vitamin d458.6IL1RN, IL11, LRP5, ACP5, PTH, TGFB2
491,25 dihydroxy vitamin d3458.5TNFRSF11B, IGFBP4, VDR, CYP27B1, IL11, LRP5
50calcium45 50 11 2411.0CALCA, PTH, TGFB2, ACP5, LRP5, IL7

GO Terms for genes affiliated with Osteoporosis, Postmenopausal

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5TNFSF11, CALCA, IBSP, BGLAP, GC, TNFRSF11B
2extracellular spaceGO:0056158.2TGFB2, COL1A2, GC, BGLAP, CALCA, TNFSF11

Biological processes related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.6TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.5TNFRSF11A, TNFSF11
3positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.5TNFRSF11A, TNFSF11
4positive regulation of adenylate cyclase activityGO:04576210.5CALCA, CALCR
5positive regulation of vitamin D 24-hydroxylase activityGO:01098010.5VDR, CYP27B1
6monocyte chemotaxisGO:00254810.4CALCA, TNFRSF11A, TNFSF11
7positive regulation of cAMP biosynthetic processGO:03081910.4CALCR, CALCA, PTH
8negative regulation of bone resorptionGO:04577910.4CALCA, TNFRSF11B
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.4CALCA, CALCR, PTH
10positive regulation of keratinocyte differentiationGO:04561810.3VDR, CYP27B1
11odontogenesisGO:04247610.3TGFB2, BGLAP, COL1A2
12regulation of blood pressureGO:00821710.3LRP5, COL1A2, CALCA
13vitamin D metabolic processGO:04235910.3GC, CYP27B1
14ossificationGO:00150310.3TNFSF11, IBSP, TNFRSF11A
15response to estrogen stimulusGO:04362710.3TNFRSF11B, CYP27B1, BGLAP
16positive regulation of ossificationGO:04577810.3TGFB2, CALCA
17response to glucocorticoid stimulusGO:05138410.2BGLAP, IL1RN, CALCR
18mammary gland alveolus developmentGO:06074910.2TNFSF11, TNFRSF11A
19bone resorptionGO:04545310.2TNFSF11, CTSK, IL7, ACP5, PTH
20extracellular matrix organizationGO:03019810.2TGFB2, CTSK, TNFRSF11B, IBSP, COL1A2
21organ morphogenesisGO:0098879.9VDR, IL7, TNFSF11
22cell-cell signalingGO:0072679.9IL11, IL7, PTH, TNFRSF11A, TGFB2, CALCA
23positive regulation of cell proliferationGO:0082849.9IL11, TGFB2, LRP5, IL7, TNFRSF11A
24skeletal system developmentGO:0015019.9COL1A2, PTH, VDR, IGFBP4, TNFRSF11B, BGLAP
25response to vitamin DGO:0332809.8CYP27B1, BGLAP
26response to drugGO:0424939.8TGFB2, IL1RN, TNFRSF11B, BGLAP

Molecular functions related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.7TGFB2, IL7, IL11, TNFRSF11B, TNFSF11

Products for genes affiliated with Osteoporosis, Postmenopausal

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Sources for Osteoporosis, Postmenopausal

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet