MCID: OST081
MIFTS: 36

Osteoporosis, Postmenopausal malady

Genetic diseases (common), Bone diseases categories

Summaries for Osteoporosis, Postmenopausal

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48OMIM, 34MalaCards
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MalaCards: Osteoporosis, Postmenopausal, also known as osteoporosis postmenopausal, is related to osteoporosis and osteoporosis, postmenopausal, susceptibility. An important gene associated with Osteoporosis, Postmenopausal is COL1A2 (collagen, type I, alpha 2), and among its related pathways are C-MYB transcription factor network and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds pyridinoline and calcium gluconate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and skeleton.

Description from OMIM:48 166710

Aliases & Classifications for Osteoporosis, Postmenopausal

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48OMIM, 46Novoseek, 26ICD10
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Related Diseases for Osteoporosis, Postmenopausal

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18GeneCards, 19GeneDecks
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Diseases related to Osteoporosis, Postmenopausal via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.5CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2osteoporosis, postmenopausal, susceptibility10.2
3camurati-engelmann disease10.1BGLAP
4osteitis fibrosa10.1BGLAP
5osteonecrosis10.1BGLAP
6periapical granuloma10.1TNFSF11
7paget's disease of bone10.1CALCA, BGLAP
8idiopathic juvenile osteoporosis10.1CALCA, BGLAP
9giant cell tumor10.1TNFSF11, CALCA
10pseudohypoparathyroidism10.1BGLAP, CALCA
11synovitis10.1TNFRSF11B, TNFSF11
12fibrous dysplasia10.1IBSP, BGLAP
13hypoparathyroidism10.1BGLAP, CALCA
14hypophosphatemia10.1BGLAP, CALCA
15cherubism10.1TNFSF11, CALCA
16polyostotic osteolytic dysplasia, hereditary expansile10.1TNFSF11, TNFRSF11B
17osteosclerosis10.1TNFSF11, TNFRSF11B
18goiter10.1BGLAP, CALCA
19osteopetrosis autosomal dominant type 210.1TNFSF11, BGLAP
20gingivitis10.0TNFSF11, TNFRSF11B
21beta thalassemia10.0TNFSF11, TNFRSF11B
22psoriatic arthritis10.0TNFSF11, TNFRSF11B
23hypogonadism10.0CALCA, BGLAP
24cholesteatoma10.0TNFRSF11B, TNFSF11
25periodontitis10.0TNFSF11, TNFRSF11B
26papillary thyroid carcinoma10.0CALCA, IBSP
27arthropathy10.0TNFSF11, TNFRSF11B
28primary hyperoxaluria10.0BGLAP, CALCA
29osteomalacia10.0CALCA, TNFRSF11B, BGLAP
30cushing's syndrome10.0BGLAP, TNFRSF11B, CALCA
31gaucher's disease10.0BGLAP, ACP5
32rickets10.0ACP5, BGLAP
33paget disease, juvenile10.0TNFSF11, TNFRSF11B, CALCA
34dentinogenesis imperfecta10.0IBSP, COL1A2
35otosclerosis10.0COL1A2, TNFRSF11B
36aortic valve stenosis10.0IBSP, TNFSF11, TNFRSF11B
37adenoameloblastoma10.0TNFRSF11B, TNFSF11, IBSP
38osteogenesis imperfecta type i10.0BGLAP, COL1A2
39multiple myeloma10.0TNFRSF11B, TNFSF11
40ankylosing spondylitis10.0BGLAP, TNFSF11, TNFRSF11B
41osteopetrosis10.0BGLAP, TNFSF11, TNFRSF11B
42coronary artery disease10.0TNFRSF11B, TNFSF11, IBSP
43rheumatic disease10.0BGLAP, TNFSF11, TNFRSF11B
44hyperthyroidism10.0ACP5, BGLAP
45microphthalmia10.0ACP5, TNFSF11
46thyroid cancer10.0TNFRSF11B, CALCA
47osteomyelitis10.0ACP5, TNFSF11, IBSP
48osteogenesis imperfecta10.0BGLAP, IBSP, COL1A2
49hypercalcemia10.0BGLAP, TNFSF11, TNFRSF11B, CALCA
50bone carcinoma10.0TNFRSF11B, TNFSF11, IBSP, BGLAP

Graphical network of the top 20 diseases related to Osteoporosis, Postmenopausal:



Diseases related to osteoporosis, postmenopausal

Symptoms for Osteoporosis, Postmenopausal

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48OMIM
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Clinical features from OMIM:

166710

Drugs & Therapeutics for Osteoporosis, Postmenopausal

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Osteoporosis, Postmenopausal

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Anatomical Context for Osteoporosis, Postmenopausal

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Animal Models for Osteoporosis, Postmenopausal or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Osteoporosis, Postmenopausal:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.8COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2MP:00053906.7CALCA, IBSP, TNFSF11, TNFRSF11B, WNT1, ACP5

Publications for Osteoporosis, Postmenopausal

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53PubMed
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Articles related to Osteoporosis, Postmenopausal:

idTitleAuthorsYear
1
Association of T869C gene polymorphism of transforming growth factor-I^1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women. (22290469)
2012

Variations for Osteoporosis, Postmenopausal

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65UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Osteoporosis, Postmenopausal:

65
id Symbol AA change Variation ID SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Expression for genes affiliated with Osteoporosis, Postmenopausal

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporosis, Postmenopausal

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Pathways for genes affiliated with Osteoporosis, Postmenopausal

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 61Thomson Reuters
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Compounds for genes affiliated with Osteoporosis, Postmenopausal

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pyridinoline4610.0TNFRSF11B, CALCA
2calcium gluconate469.6BGLAP, CALCA
3ipriflavone469.5CALCA, BGLAP
4hcc-1469.4TNFSF11, TNFRSF11B
5etidronate469.3BGLAP, CALCA, TNFRSF11B
6tibolone469.2CALCA, BGLAP, ACP5
7strontium ranelate469.2CALCA, TNFSF11, IBSP
8denosumab46 1210.1TNFSF11, CALCA, TNFRSF11B
9deflazacort469.0TNFRSF11B, BGLAP
10mevalonate468.8IBSP, TNFRSF11B, TNFSF11
11ns 39846 629.8TNFRSF11B, TNFSF11, BGLAP
12infliximab46 52 1210.7BGLAP, TNFSF11, TNFRSF11B
13pmma468.6TNFSF11, ACP5, CALCA, TNFRSF11B
14teriparatide46 129.5CALCA, TNFRSF11B, TNFSF11, BGLAP
15vitamin k2468.5BGLAP, TNFRSF11B, TNFSF11, CALCA
16tartrate468.5ACP5, BGLAP, TNFSF11, CALCA
17pamidronate46 52 1210.5BGLAP, CALCA, TNFRSF11B, TNFSF11
18risedronate46 52 30 62 1212.5CALCA, BGLAP, TNFRSF11B, TNFSF11
19alendronate46 52 1210.5BGLAP, CALCA, TNFSF11, TNFRSF11B
20aspartate468.5BGLAP, COL1A2, ACP5, TNFRSF11B
21raloxifene46 52 30 1211.5TNFRSF11B, CALCA, BGLAP, TNFSF11
22hydroxyproline46 25 1210.4BGLAP, ACP5, TNFRSF11B, IBSP, CALCA
23azathioprine46 3 52 1211.3BGLAP, TNFSF11, TNFRSF11B, ACP5
24ascorbic acid46 259.3BGLAP, TNFSF11, IBSP, TNFRSF11B
25phosphatidylinositol468.2WNT1, IBSP, TNFSF11, COL1A2, TNFRSF11B
26forskolin46 52 1210.2TNFRSF11B, CALCA, TNFSF11, IBSP
27ibandronate46 129.1TNFSF11, BGLAP, IBSP, TNFRSF11B, CALCA
28zoledronic acid468.1IBSP, TNFSF11, TNFRSF11B, BGLAP, CALCA
29paraffin468.1ACP5, TNFSF11, IBSP, BGLAP
30clodronate46 52 1210.0TNFSF11, TNFRSF11B, ACP5, CALCA, BGLAP
3125-hydroxyvitamin d468.0CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
32phosphorus468.0TNFRSF11B, CALCA, BGLAP, ACP5, TNFSF11
33titanium468.0ACP5, TNFRSF11B, IBSP, TNFSF11, BGLAP
34calcitriol46 62 25 1211.0TNFSF11, TNFRSF11B, BGLAP, CALCA, ACP5
35hydroxyapatite467.9BGLAP, IBSP, TNFRSF11B, TNFSF11, ACP5
36cyclosporin a46 30 629.9TNFRSF11B, ACP5, BGLAP, TNFSF11, CALCA
37vegf467.9BGLAP, IBSP, TNFSF11, TNFRSF11B, CALCA
38estradiol46 25 129.9TNFSF11, BGLAP, TNFRSF11B, ACP5, IBSP
39heparin46 30 25 1210.9TNFRSF11B, ACP5, TNFSF11, BGLAP, IBSP
40dexamethasone46 52 30 1210.8TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
41tyrosine467.6COL1A2, ACP5, TNFSF11, TNFRSF11B, WNT1, IBSP
42procollagen467.6ACP5, COL1A2, IBSP, BGLAP, TNFRSF11B, TNFSF11
43deoxypyridinoline467.6TNFSF11, TNFRSF11B, IBSP, BGLAP, CALCA, ACP5
441,25 dihydroxy vitamin d3467.6CALCA, TNFSF11, IBSP, TNFRSF11B, BGLAP, ACP5
45cysteine467.5COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP, BGLAP
46pge2467.5IBSP, CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
47creatinine467.5ACP5, CALCA, TNFSF11, IBSP, BGLAP, TNFRSF11B
48vitamin d467.2CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
49calcium46 52 25 1210.1BGLAP, IBSP, ACP5, COL1A2, CALCA, TNFRSF11B
50estrogen466.8TNFSF11, BGLAP, ACP5, COL1A2, CALCA, IBSP

GO Terms for genes affiliated with Osteoporosis, Postmenopausal

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17Gene Ontology
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Cellular components related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CALCA, COL1A2, WNT1, TNFRSF11B, TNFSF11, BGLAP
2extracellular regionGO:0055766.6CALCA, BGLAP, IBSP, TNFSF11, TNFRSF11B, WNT1

Biological processes related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of bone resorptionGO:0457799.8CALCA, TNFRSF11B
2odontogenesisGO:0424769.7COL1A2, BGLAP
3bone developmentGO:0603489.6WNT1, BGLAP
4regulation of blood pressureGO:0082179.6COL1A2, CALCA
5monocyte chemotaxisGO:0025489.5CALCA, TNFSF11
6cellular response to growth factor stimulusGO:0713639.5IBSP, BGLAP
7response to estrogenGO:0436279.3TNFRSF11B, BGLAP
8bone resorptionGO:0454539.3TNFSF11, ACP5
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3WNT1, TNFSF11
10extracellular matrix organizationGO:0301989.3IBSP, TNFRSF11B, COL1A2
11skeletal system developmentGO:0015019.2COL1A2, TNFRSF11B, BGLAP
12ossificationGO:0015038.9TNFSF11, IBSP

Molecular functions related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8WNT1, TNFRSF11B, TNFSF11

Products for genes affiliated with Osteoporosis, Postmenopausal

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Sources for Osteoporosis, Postmenopausal

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet