MCID: OST081
MIFTS: 36

Osteoporosis, Postmenopausal malady

Genetic diseases (common), Bone diseases categories
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Summaries for Osteoporosis, Postmenopausal

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47OMIM, 33MalaCards
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MalaCards: Osteoporosis, Postmenopausal, also known as osteoporosis postmenopausal, is related to osteoporosis and osteoporosis, postmenopausal, susceptibility. An important gene associated with Osteoporosis, Postmenopausal is COL1A2 (collagen, type I, alpha 2), and among its related pathways are C-MYB transcription factor network and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds pyridinoline and calcium gluconate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and skeleton.

Description from OMIM:47 166710

Aliases & Classifications for Osteoporosis, Postmenopausal

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47OMIM, 45Novoseek, 25ICD10
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Related Diseases for Osteoporosis, Postmenopausal

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17GeneCards, 18GeneDecks
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Diseases related to Osteoporosis, Postmenopausal via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.5CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2osteoporosis, postmenopausal, susceptibility10.2
3camurati-engelmann disease10.1BGLAP
4osteitis fibrosa10.1BGLAP
5osteonecrosis10.1BGLAP
6periapical granuloma10.1TNFSF11
7paget's disease of bone10.1CALCA, BGLAP
8idiopathic juvenile osteoporosis10.1CALCA, BGLAP
9giant cell tumor10.1TNFSF11, CALCA
10pseudohypoparathyroidism10.1BGLAP, CALCA
11synovitis10.1TNFRSF11B, TNFSF11
12fibrous dysplasia10.1IBSP, BGLAP
13hypoparathyroidism10.1BGLAP, CALCA
14hypophosphatemia10.1BGLAP, CALCA
15cherubism10.1TNFSF11, CALCA
16polyostotic osteolytic dysplasia, hereditary expansile10.1TNFSF11, TNFRSF11B
17osteosclerosis10.1TNFSF11, TNFRSF11B
18goiter10.1BGLAP, CALCA
19osteopetrosis autosomal dominant type 210.1TNFSF11, BGLAP
20gingivitis10.0TNFSF11, TNFRSF11B
21beta thalassemia10.0TNFSF11, TNFRSF11B
22psoriatic arthritis10.0TNFSF11, TNFRSF11B
23hypogonadism10.0CALCA, BGLAP
24cholesteatoma10.0TNFRSF11B, TNFSF11
25periodontitis10.0TNFSF11, TNFRSF11B
26papillary thyroid carcinoma10.0CALCA, IBSP
27arthropathy10.0TNFSF11, TNFRSF11B
28primary hyperoxaluria10.0BGLAP, CALCA
29osteomalacia10.0CALCA, TNFRSF11B, BGLAP
30cushing's syndrome10.0BGLAP, TNFRSF11B, CALCA
31gaucher's disease10.0BGLAP, ACP5
32rickets10.0ACP5, BGLAP
33paget disease, juvenile10.0TNFSF11, TNFRSF11B, CALCA
34dentinogenesis imperfecta10.0IBSP, COL1A2
35otosclerosis10.0COL1A2, TNFRSF11B
36aortic valve stenosis10.0IBSP, TNFSF11, TNFRSF11B
37adenoameloblastoma10.0TNFRSF11B, TNFSF11, IBSP
38osteogenesis imperfecta type i10.0BGLAP, COL1A2
39multiple myeloma10.0TNFRSF11B, TNFSF11
40ankylosing spondylitis10.0BGLAP, TNFSF11, TNFRSF11B
41osteopetrosis10.0BGLAP, TNFSF11, TNFRSF11B
42coronary artery disease10.0TNFRSF11B, TNFSF11, IBSP
43rheumatic disease10.0BGLAP, TNFSF11, TNFRSF11B
44hyperthyroidism10.0ACP5, BGLAP
45microphthalmia10.0ACP5, TNFSF11
46thyroid cancer10.0TNFRSF11B, CALCA
47osteomyelitis10.0ACP5, TNFSF11, IBSP
48osteogenesis imperfecta10.0BGLAP, IBSP, COL1A2
49hypercalcemia10.0BGLAP, TNFSF11, TNFRSF11B, CALCA
50bone carcinoma10.0TNFRSF11B, TNFSF11, IBSP, BGLAP

Graphical network of the top 20 diseases related to Osteoporosis, Postmenopausal:



Diseases related to osteoporosis, postmenopausal

Symptoms for Osteoporosis, Postmenopausal

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47OMIM
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Clinical features from OMIM:

166710

Drugs & Therapeutics for Osteoporosis, Postmenopausal

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Osteoporosis, Postmenopausal

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Anatomical Context for Osteoporosis, Postmenopausal

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Animal Models for Osteoporosis, Postmenopausal or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Osteoporosis, Postmenopausal:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.8COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2MP:00053906.7CALCA, IBSP, TNFSF11, TNFRSF11B, WNT1, ACP5

Publications for Osteoporosis, Postmenopausal

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52PubMed
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Articles related to Osteoporosis, Postmenopausal:

idTitleAuthorsYear
1
Association of T869C gene polymorphism of transforming growth factor-I^1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women. (22290469)
2012

Variations for Osteoporosis, Postmenopausal

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64UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Osteoporosis, Postmenopausal:

64
id Symbol AA change Variation ID SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Expression for genes affiliated with Osteoporosis, Postmenopausal

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporosis, Postmenopausal

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Pathways for genes affiliated with Osteoporosis, Postmenopausal

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters
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Compounds for genes affiliated with Osteoporosis, Postmenopausal

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pyridinoline4510.0TNFRSF11B, CALCA
2calcium gluconate459.6BGLAP, CALCA
3ipriflavone459.5CALCA, BGLAP
4hcc-1459.4TNFSF11, TNFRSF11B
5etidronate459.3BGLAP, CALCA, TNFRSF11B
6tibolone459.2CALCA, BGLAP, ACP5
7strontium ranelate459.2CALCA, TNFSF11, IBSP
8denosumab45 1110.1TNFSF11, CALCA, TNFRSF11B
9deflazacort459.0TNFRSF11B, BGLAP
10mevalonate458.8IBSP, TNFRSF11B, TNFSF11
11ns 39845 619.8TNFRSF11B, TNFSF11, BGLAP
12infliximab45 51 1110.7BGLAP, TNFSF11, TNFRSF11B
13pmma458.6TNFSF11, ACP5, CALCA, TNFRSF11B
14teriparatide45 119.5CALCA, TNFRSF11B, TNFSF11, BGLAP
15vitamin k2458.5BGLAP, TNFRSF11B, TNFSF11, CALCA
16tartrate458.5ACP5, BGLAP, TNFSF11, CALCA
17pamidronate45 51 1110.5BGLAP, CALCA, TNFRSF11B, TNFSF11
18risedronate45 51 29 61 1112.5CALCA, BGLAP, TNFRSF11B, TNFSF11
19alendronate45 51 1110.5BGLAP, CALCA, TNFSF11, TNFRSF11B
20aspartate458.5BGLAP, COL1A2, ACP5, TNFRSF11B
21raloxifene45 51 29 1111.5TNFRSF11B, CALCA, BGLAP, TNFSF11
22hydroxyproline45 24 1110.4BGLAP, ACP5, TNFRSF11B, IBSP, CALCA
23azathioprine45 3 51 1111.3BGLAP, TNFSF11, TNFRSF11B, ACP5
24ascorbic acid45 249.3BGLAP, TNFSF11, IBSP, TNFRSF11B
25phosphatidylinositol458.2WNT1, IBSP, TNFSF11, COL1A2, TNFRSF11B
26forskolin45 51 1110.2TNFRSF11B, CALCA, TNFSF11, IBSP
27ibandronate45 119.1TNFSF11, BGLAP, IBSP, TNFRSF11B, CALCA
28zoledronic acid458.1IBSP, TNFSF11, TNFRSF11B, BGLAP, CALCA
29paraffin458.1ACP5, TNFSF11, IBSP, BGLAP
30clodronate45 51 1110.0TNFSF11, TNFRSF11B, ACP5, CALCA, BGLAP
3125-hydroxyvitamin d458.0CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
32phosphorus458.0TNFRSF11B, CALCA, BGLAP, ACP5, TNFSF11
33titanium458.0ACP5, TNFRSF11B, IBSP, TNFSF11, BGLAP
34calcitriol45 61 24 1111.0TNFSF11, TNFRSF11B, BGLAP, CALCA, ACP5
35hydroxyapatite457.9BGLAP, IBSP, TNFRSF11B, TNFSF11, ACP5
36cyclosporin a45 29 619.9TNFRSF11B, ACP5, BGLAP, TNFSF11, CALCA
37vegf457.9BGLAP, IBSP, TNFSF11, TNFRSF11B, CALCA
38estradiol45 24 119.9TNFSF11, BGLAP, TNFRSF11B, ACP5, IBSP
39heparin45 29 24 1110.9TNFRSF11B, ACP5, TNFSF11, BGLAP, IBSP
40dexamethasone45 51 29 1110.8TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
41tyrosine457.6COL1A2, ACP5, TNFSF11, TNFRSF11B, WNT1, IBSP
42procollagen457.6ACP5, COL1A2, IBSP, BGLAP, TNFRSF11B, TNFSF11
43deoxypyridinoline457.6TNFSF11, TNFRSF11B, IBSP, BGLAP, CALCA, ACP5
441,25 dihydroxy vitamin d3457.6CALCA, TNFSF11, IBSP, TNFRSF11B, BGLAP, ACP5
45cysteine457.5COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP, BGLAP
46pge2457.5IBSP, CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
47creatinine457.5ACP5, CALCA, TNFSF11, IBSP, BGLAP, TNFRSF11B
48vitamin d457.2CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
49calcium45 51 24 1110.1BGLAP, IBSP, ACP5, COL1A2, CALCA, TNFRSF11B
50estrogen456.8TNFSF11, BGLAP, ACP5, COL1A2, CALCA, IBSP

GO Terms for genes affiliated with Osteoporosis, Postmenopausal

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16Gene Ontology
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Cellular components related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CALCA, COL1A2, WNT1, TNFRSF11B, TNFSF11, BGLAP
2extracellular regionGO:0055766.6CALCA, BGLAP, IBSP, TNFSF11, TNFRSF11B, WNT1

Biological processes related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of bone resorptionGO:0457799.8CALCA, TNFRSF11B
2odontogenesisGO:0424769.7COL1A2, BGLAP
3bone developmentGO:0603489.6WNT1, BGLAP
4regulation of blood pressureGO:0082179.6COL1A2, CALCA
5monocyte chemotaxisGO:0025489.5CALCA, TNFSF11
6cellular response to growth factor stimulusGO:0713639.5IBSP, BGLAP
7response to estrogenGO:0436279.3TNFRSF11B, BGLAP
8bone resorptionGO:0454539.3TNFSF11, ACP5
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3WNT1, TNFSF11
10extracellular matrix organizationGO:0301989.3IBSP, TNFRSF11B, COL1A2
11skeletal system developmentGO:0015019.2COL1A2, TNFRSF11B, BGLAP
12ossificationGO:0015038.9TNFSF11, IBSP

Molecular functions related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8WNT1, TNFRSF11B, TNFSF11

Products for genes affiliated with Osteoporosis, Postmenopausal

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Sources for Osteoporosis, Postmenopausal

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet