MCID: OST081
MIFTS: 36

Osteoporosis, Postmenopausal malady

Genetic diseases (common), Bone diseases categories
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Summaries for Osteoporosis, Postmenopausal

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MalaCards based summary: Osteoporosis, Postmenopausal, also known as osteoporosis postmenopausal, is related to osteoporosis and camurati-engelmann disease. An important gene associated with Osteoporosis, Postmenopausal is COL1A2 (collagen, type I, alpha 2), and among its related pathways are C-MYB transcription factor network and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds pyridinoline and calcium gluconate have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and skeleton.

Description from OMIM:46 166710

Aliases & Classifications for Osteoporosis, Postmenopausal

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Sources:
46OMIM, 44Novoseek, 25ICD10
See all sources

Osteoporosis, Postmenopausal, Aliases & Descriptions:

Name: Osteoporosis, Postmenopausal 46
 
Osteoporosis Postmenopausal 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Bone diseases


External Ids:

ICD1025 M80.0, M81.0

Related Diseases for Osteoporosis, Postmenopausal

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Diseases related to Osteoporosis, Postmenopausal via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis29.6CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2camurati-engelmann disease10.4BGLAP
3osteitis fibrosa10.4BGLAP
4osteonecrosis10.4BGLAP
5periapical granuloma10.4TNFSF11
6paget's disease of bone10.3CALCA, BGLAP
7idiopathic juvenile osteoporosis10.3CALCA, BGLAP
8giant cell tumor10.3TNFSF11, CALCA
9pseudohypoparathyroidism10.3BGLAP, CALCA
10synovitis10.3TNFRSF11B, TNFSF11
11fibrous dysplasia10.3IBSP, BGLAP
12osteoporosis, postmenopausal, susceptibility10.3
13hypoparathyroidism10.3BGLAP, CALCA
14hypophosphatemia10.2BGLAP, CALCA
15cherubism10.2TNFSF11, CALCA
16polyostotic osteolytic dysplasia, hereditary expansile10.2TNFSF11, TNFRSF11B
17osteosclerosis10.2TNFSF11, TNFRSF11B
18goiter10.2BGLAP, CALCA
19osteopetrosis autosomal dominant type 210.2TNFSF11, BGLAP
20gingivitis10.2TNFSF11, TNFRSF11B
21beta thalassemia10.2TNFSF11, TNFRSF11B
22psoriatic arthritis10.2TNFSF11, TNFRSF11B
23hypogonadism10.2CALCA, BGLAP
24cholesteatoma10.2TNFRSF11B, TNFSF11
25periodontitis10.2TNFSF11, TNFRSF11B
26papillary thyroid carcinoma10.2CALCA, IBSP
27arthropathy10.1TNFSF11, TNFRSF11B
28primary hyperoxaluria10.1BGLAP, CALCA
29osteomalacia10.1CALCA, TNFRSF11B, BGLAP
30cushing's syndrome10.1BGLAP, TNFRSF11B, CALCA
31gaucher's disease10.1BGLAP, ACP5
32rickets10.1ACP5, BGLAP
33paget disease, juvenile10.1TNFSF11, TNFRSF11B, CALCA
34dentinogenesis imperfecta10.1IBSP, COL1A2
35otosclerosis10.1COL1A2, TNFRSF11B
36aortic valve stenosis10.1IBSP, TNFSF11, TNFRSF11B
37ameloblastoma10.1TNFRSF11B, TNFSF11, IBSP
38osteogenesis imperfecta type i10.1BGLAP, COL1A2
39multiple myeloma10.1TNFRSF11B, TNFSF11
40ankylosing spondylitis10.1BGLAP, TNFSF11, TNFRSF11B
41osteopetrosis10.1BGLAP, TNFSF11, TNFRSF11B
42coronary artery anomaly10.1TNFRSF11B, TNFSF11, IBSP
43rheumatic disease10.1BGLAP, TNFSF11, TNFRSF11B
44hyperthyroidism10.0ACP5, BGLAP
45microphthalmia10.0ACP5, TNFSF11
46thyroid hurthle cell carcinoma10.0TNFRSF11B, CALCA
47osteomyelitis10.0ACP5, TNFSF11, IBSP
48osteogenesis imperfecta9.9BGLAP, IBSP, COL1A2
49hypercalcemia9.9BGLAP, TNFSF11, TNFRSF11B, CALCA
50bone cancer9.9TNFRSF11B, TNFSF11, IBSP, BGLAP

Graphical network of the top 20 diseases related to Osteoporosis, Postmenopausal:



Diseases related to osteoporosis, postmenopausal

Symptoms for Osteoporosis, Postmenopausal

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Clinical features from OMIM:

166710

Drugs & Therapeutics for Osteoporosis, Postmenopausal

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Drug clinical trials:

Search ClinicalTrials for Osteoporosis, Postmenopausal

Search NIH Clinical Center for Osteoporosis, Postmenopausal

Genetic Tests for Osteoporosis, Postmenopausal

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Anatomical Context for Osteoporosis, Postmenopausal

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Animal Models for Osteoporosis, Postmenopausal or affiliated genes

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MGI Mouse Phenotypes related to Osteoporosis, Postmenopausal:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053717.8COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
2MP:00053906.7CALCA, IBSP, TNFSF11, TNFRSF11B, WNT1, ACP5

Publications for Osteoporosis, Postmenopausal

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Articles related to Osteoporosis, Postmenopausal:

idTitleAuthorsYear
1
Association of T869C gene polymorphism of transforming growth factor-I^1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women. (22290469)
2012

Variations for Osteoporosis, Postmenopausal

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UniProtKB/Swiss-Prot genetic disease variations for Osteoporosis, Postmenopausal:

64
id Symbol AA change Variation ID SNP ID
1WNT1p.Cys218GlyVAR_069629
2WNT1p.Arg235TrpVAR_069630

Clinvar genetic disease variations for Osteoporosis, Postmenopausal:

6
id Gene Name Type Significance SNP ID Assembly Location
1COL1A2NM_000089.3(COL1A2): c.1981G> A (p.Gly661Ser)single nucleotide variantPathogenicrs72658152GRCh37Chr 7, 94047820: 94047820

Expression for genes affiliated with Osteoporosis, Postmenopausal

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Expression patterns in normal tissues for genes affiliated with Osteoporosis, Postmenopausal

Search GEO for disease gene expression data for Osteoporosis, Postmenopausal.

Pathways for genes affiliated with Osteoporosis, Postmenopausal

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Compounds for genes affiliated with Osteoporosis, Postmenopausal

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Compounds related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pyridinoline4410.0TNFRSF11B, CALCA
2calcium gluconate449.6BGLAP, CALCA
3ipriflavone449.5CALCA, BGLAP
4hcc-1449.4TNFSF11, TNFRSF11B
5etidronate449.3BGLAP, CALCA, TNFRSF11B
6tibolone449.2CALCA, BGLAP, ACP5
7strontium ranelate449.2CALCA, TNFSF11, IBSP
8denosumab44 1110.1TNFSF11, CALCA, TNFRSF11B
9deflazacort449.0TNFRSF11B, BGLAP
10mevalonate448.8IBSP, TNFRSF11B, TNFSF11
11ns 39844 619.8TNFRSF11B, TNFSF11, BGLAP
12infliximab44 50 1110.7BGLAP, TNFSF11, TNFRSF11B
13pmma448.6TNFSF11, ACP5, CALCA, TNFRSF11B
14teriparatide44 119.5CALCA, TNFRSF11B, TNFSF11, BGLAP
15vitamin k2448.5BGLAP, TNFRSF11B, TNFSF11, CALCA
16tartrate448.5ACP5, BGLAP, TNFSF11, CALCA
17pamidronate44 50 1110.5BGLAP, CALCA, TNFRSF11B, TNFSF11
18risedronate44 50 28 61 1112.5CALCA, BGLAP, TNFRSF11B, TNFSF11
19alendronate44 50 1110.5BGLAP, CALCA, TNFSF11, TNFRSF11B
20aspartate448.5BGLAP, COL1A2, ACP5, TNFRSF11B
21raloxifene44 50 28 1111.5TNFRSF11B, CALCA, BGLAP, TNFSF11
22hydroxyproline44 24 1110.4BGLAP, ACP5, TNFRSF11B, IBSP, CALCA
23azathioprine44 2 50 1111.3BGLAP, TNFSF11, TNFRSF11B, ACP5
24ascorbic acid44 249.3BGLAP, TNFSF11, IBSP, TNFRSF11B
25phosphatidylinositol448.2WNT1, IBSP, TNFSF11, COL1A2, TNFRSF11B
26forskolin44 50 1110.2TNFRSF11B, CALCA, TNFSF11, IBSP
27ibandronate44 119.1TNFSF11, BGLAP, IBSP, TNFRSF11B, CALCA
28zoledronic acid448.1IBSP, TNFSF11, TNFRSF11B, BGLAP, CALCA
29paraffin448.1ACP5, TNFSF11, IBSP, BGLAP
30clodronate44 50 1110.0TNFSF11, TNFRSF11B, ACP5, CALCA, BGLAP
3125-hydroxyvitamin d448.0CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
32phosphorus448.0TNFRSF11B, CALCA, BGLAP, ACP5, TNFSF11
33titanium448.0ACP5, TNFRSF11B, IBSP, TNFSF11, BGLAP
34calcitriol44 61 24 1111.0TNFSF11, TNFRSF11B, BGLAP, CALCA, ACP5
35hydroxyapatite447.9BGLAP, IBSP, TNFRSF11B, TNFSF11, ACP5
36cyclosporin a44 28 619.9TNFRSF11B, ACP5, BGLAP, TNFSF11, CALCA
37vegf447.9BGLAP, IBSP, TNFSF11, TNFRSF11B, CALCA
38estradiol44 24 119.9TNFSF11, BGLAP, TNFRSF11B, ACP5, IBSP
39heparin44 28 24 1110.9TNFRSF11B, ACP5, TNFSF11, BGLAP, IBSP
40dexamethasone44 50 28 1110.8TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
41tyrosine447.6COL1A2, ACP5, TNFSF11, TNFRSF11B, WNT1, IBSP
42procollagen447.6ACP5, COL1A2, IBSP, BGLAP, TNFRSF11B, TNFSF11
43deoxypyridinoline447.6TNFSF11, TNFRSF11B, IBSP, BGLAP, CALCA, ACP5
441,25 dihydroxy vitamin d3447.6CALCA, TNFSF11, IBSP, TNFRSF11B, BGLAP, ACP5
45cysteine447.5COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP, BGLAP
46pge2447.5IBSP, CALCA, ACP5, TNFRSF11B, BGLAP, TNFSF11
47creatinine447.5ACP5, CALCA, TNFSF11, IBSP, BGLAP, TNFRSF11B
48vitamin d447.2CALCA, COL1A2, ACP5, TNFRSF11B, TNFSF11, IBSP
49calcium44 50 24 1110.1BGLAP, IBSP, ACP5, COL1A2, CALCA, TNFRSF11B
50estrogen446.8TNFSF11, BGLAP, ACP5, COL1A2, CALCA, IBSP

GO Terms for genes affiliated with Osteoporosis, Postmenopausal

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Cellular components related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.4CALCA, COL1A2, WNT1, TNFRSF11B, TNFSF11, BGLAP
2extracellular regionGO:0055766.6CALCA, BGLAP, IBSP, TNFSF11, TNFRSF11B, WNT1

Biological processes related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of bone resorptionGO:0457799.8CALCA, TNFRSF11B
2odontogenesisGO:0424769.7COL1A2, BGLAP
3bone developmentGO:0603489.6WNT1, BGLAP
4regulation of blood pressureGO:0082179.6COL1A2, CALCA
5monocyte chemotaxisGO:0025489.5CALCA, TNFSF11
6cellular response to growth factor stimulusGO:0713639.5IBSP, BGLAP
7response to estrogenGO:0436279.3TNFRSF11B, BGLAP
8bone resorptionGO:0454539.3TNFSF11, ACP5
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3WNT1, TNFSF11
10extracellular matrix organizationGO:0301989.3IBSP, TNFRSF11B, COL1A2
11skeletal system developmentGO:0015019.2COL1A2, TNFRSF11B, BGLAP
12ossificationGO:0015038.9TNFSF11, IBSP

Molecular functions related to Osteoporosis, Postmenopausal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8WNT1, TNFRSF11B, TNFSF11

Products for genes affiliated with Osteoporosis, Postmenopausal

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Sources for Osteoporosis, Postmenopausal

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet