MCID: OST097
MIFTS: 28

Osteoporotic Fracture malady

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

Aliases & Descriptions for Osteoporotic Fracture:

Name: Osteoporotic Fracture 52
Osteoporotic Fractures 69

Classifications:



Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to bone mineral density qtl18, osteoporosis and osteoporosis. An important gene associated with Osteoporotic Fracture is COL1A1 (Collagen Type I Alpha 1 Chain). The drugs Alendronate and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and breast.

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 bone mineral density qtl18, osteoporosis 11.1
2 osteoporosis 10.3
3 osteoarthritis 10.0
4 breast cancer 9.9
5 rheumatoid arthritis 9.8
6 hyperprolactinemia 9.8
7 arthritis 9.8
8 atrial fibrillation 9.8
9 cervicitis 9.8
10 postural hypotension 9.8
11 systemic lupus erythematosus 9.7
12 prostate cancer 9.7
13 obesity 9.7
14 anorexia nervosa 9.7
15 insulin-like growth factor i 9.7
16 liver disease 9.7
17 osteonecrosis 9.7
18 spinal cord injury 9.7
19 spinal stenosis 9.7
20 cervical dystonia 9.7
21 hyperparathyroidism 9.7
22 prostatitis 9.7
23 periodontal disease 9.7
24 empty sella syndrome 9.7
25 dystonia 9.7
26 cerebrovascular disease 9.7
27 periodontitis 9.7
28 lupus erythematosus 9.7
29 fatty liver disease 9.7
30 irritable bowel syndrome 9.7
31 back pain 9.7
32 osteonecrosis of the jaw 9.7

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

Drugs & Therapeutics for Osteoporotic Fracture

Drugs for Osteoporotic Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4,Phase 3 121268-17-5, 66376-36-1 2088
2
Zoledronic acid Approved Phase 4,Phase 3 118072-93-8 68740
3
Calcium carbonate Approved Phase 4,Phase 3 471-34-1
4
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2 52232-67-4 16133850
5
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
6
Etidronic acid Approved Phase 4,Phase 3 7414-83-7, 2809-21-4 3305
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
8
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
9
Denosumab Approved Phase 4,Phase 3 615258-40-7
10
Menthol Approved Phase 4 2216-51-5 16666
11
Tranexamic Acid Approved Phase 4 1197-18-8 5526
12
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
13 vitamin d Phase 4,Phase 3,Phase 2
14 Risedronate Sodium Phase 4,Phase 3 115436-72-1
15 Analgesics Phase 4,Phase 3,Phase 2
16 Gastrointestinal Agents Phase 4,Phase 3
17 Trace Elements Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2
19 Anesthetics Phase 4,Phase 3,Phase 2
20 Diphosphonates Phase 4,Phase 3,Phase 2
21 Hormones Phase 4,Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
23 Anesthetics, Local Phase 4,Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
25 Antacids Phase 4,Phase 3
26 Ergocalciferols Phase 4,Phase 3,Phase 2
27 Vitamins Phase 4,Phase 3,Phase 2
28 Polymethyl Methacrylate Phase 4,Phase 3
29 Anti-Ulcer Agents Phase 4,Phase 3
30 Micronutrients Phase 4,Phase 3,Phase 2
31 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
32 Calcium, Dietary Phase 4,Phase 3,Phase 2
33 calcium channel blockers Phase 4,Phase 3
34 glucocorticoids Phase 4,Phase 3,Phase 2
35 Sodium Channel Blockers Phase 4,Phase 3
36 Diuretics, Potassium Sparing Phase 4,Phase 3
37 Vasodilator Agents Phase 4,Phase 3
38 Anti-Arrhythmia Agents Phase 4,Phase 3
39 Hypoglycemic Agents Phase 4,Phase 2
40 Anticonvulsants Phase 4
41 Protective Agents Phase 4,Phase 3
42 Liver Extracts Phase 4
43 Central Nervous System Depressants Phase 4,Phase 3
44 Coagulants Phase 4,Phase 2
45 Hemostatics Phase 4,Phase 2
46 Antifibrinolytic Agents Phase 4
47 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2
48 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2
49 Calamus Nutraceutical Phase 4
50
Tamoxifen Approved Phase 3 10540-29-1 2733526

Interventional clinical trials:

(show top 50) (show all 198)
id Name Status NCT ID Phase
1 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4
2 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
3 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4
4 Vertebroplasty Compared With a Sham-procedure for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01537770 Phase 4
5 Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting Completed NCT01847898 Phase 4
6 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4
7 Comparison of Balloon Kyphoplasty and Vertebroplasty in Subacute Osteoporotic Vertebral Fractures Completed NCT00749086 Phase 4
8 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Completed NCT01383616 Phase 4
9 Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace Completed NCT02049931 Phase 4
10 VERtebral Fracture Treatment Comparisons in Osteoporotic Women Completed NCT01709110 Phase 4
11 Antiepileptic Drugs and Osteoporotic Prevention Trial Completed NCT00869622 Phase 4
12 Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid Completed NCT00679978 Phase 4
13 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
14 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4
15 Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) Recruiting NCT02589600 Phase 4
16 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Recruiting NCT02148848 Phase 4
17 Preventing Osteoporosis Using Denosumab Recruiting NCT02753283 Phase 4
18 Study About the Effect of Preventive Adjacent Level Cement Augmentation After Osteoporotic Vertebral Compression Fractures Recruiting NCT02489825 Phase 4
19 Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis Recruiting NCT03087851 Phase 4
20 Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures Not yet recruiting NCT02908516 Phase 4
21 Generic Zoledronic Acid Versus Original Zoledronic Acid in Postmenopausal Osteoporotic Women Not yet recruiting NCT03158246 Phase 4
22 The PRIORi-T Trial--Prospective Randomized Investigation of Radiofrequency Targeted Vertebral Augmentation Withdrawn NCT01480167 Phase 4
23 Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy Unknown status NCT01512446 Phase 3
24 Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer Unknown status NCT00957606 Phase 3
25 Early Rehabilitation After Hip Fracture Unknown status NCT00133640 Phase 3
26 Safety and Efficacy Study of Percutaneous Vertebroplasty for Painful Acute Osteoporotic Spine Fractures Unknown status NCT01677806 Phase 3
27 Secondary Prevention of Osteoporotic Fractures in Residents of Long-Term Care Facilities Completed NCT00280943 Phase 2, Phase 3
28 BONDIR Study: A Study of Intravenous Bonviva (Ibandronate) After Recent Vertebral Osteoporotic Fracture in Patients With Osteoporosis. Completed NCT00493623 Phase 3
29 Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture Completed NCT00046254 Phase 3
30 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis Completed NCT00068822 Phase 3
31 Secondary Prevention of Osteoporosis Completed NCT00421343 Phase 3
32 Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing Completed NCT01293721 Phase 2, Phase 3
33 Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer Completed NCT00859703 Phase 3
34 Low-magnitude High-frequency Vibration Study on Fracture Rate in Community Elderly Completed NCT00973167 Phase 2, Phase 3
35 BREAST CANCER AND EXERCISE Completed NCT00639210 Phase 3
36 The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis Completed NCT00252421 Phase 3
37 Calcium and Vitamin D Malnutrition in Elderly Women Completed NCT00352170 Phase 3
38 Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis Completed NCT00670319 Phase 3
39 Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis Completed NCT00680953 Phase 3
40 Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy Completed NCT00053898 Phase 3
41 A Trial of Vertebroplasty for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01200277 Phase 3
42 Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial CAN-NCIC-MA27 Completed NCT00354302 Phase 3
43 Cost Effectiveness and Efficacy of Kyphoplasty and Vertebroplasty Trial Completed NCT00279877 Phase 3
44 A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018) Completed NCT00529373 Phase 3
45 Trial to Evaluate Tibolone in the Treatment of Osteoporosis (P06468) Completed NCT00519857 Phase 3
46 Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis Completed NCT00343252 Phase 3
47 The Kiva® System as a Vertebral Augmentation Treatment Completed NCT01123512 Phase 3
48 Teriparatide Use in Hip Replaced Subjects Completed NCT00191321 Phase 3
49 A New Active Vitamin D, ED-71 for Osteoporosis Completed NCT00144456 Phase 3
50 Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women Completed NCT00205777 Phase 3

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

39
Bone, Testes, Breast, Prostate, Liver, Spinal Cord, Heart

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 373)
id Title Authors Year
1
Efficacy of Kirschner-wires and tension band in hip arthroplasty for aged patients with unstable intertrochanteric osteoporotic fracture: A 2-to-11-year follow-up. ( 28072698 )
2017
2
Added clinical use of trabecular bone score to BMD for major osteoporotic fracture prediction in older Chinese people: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 27725999 )
2017
3
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease. ( 28530467 )
2017
4
Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk. ( 27465306 )
2016
5
Perceived stress and risk of any osteoporotic fracture. ( 26786258 )
2016
6
Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture. ( 27294077 )
2016
7
The Association Between Protein Intake by Source and Osteoporotic Fracture in Older Men: A Prospective Cohort Study. ( 27943394 )
2016
8
Metabolic syndrome and osteoporotic fracture: a population-based study in China. ( 27233999 )
2016
9
Risk and clinical predictors of osteoporotic fracture in East Asian patients with chronic obstructive pulmonary disease: a population-based cohort study. ( 27812429 )
2016
10
A Study on the Correlation of Pertrochanteric Osteoporotic Fracture Severity with the Severity of Osteoporosis. ( 27190907 )
2016
11
Effects of Roughly Focused Extracorporeal Shock Waves Therapy on the Expressions of Bone Morphogenetic Protein-2 and Osteoprotegerin in Osteoporotic Fracture in Rats. ( 27779163 )
2016
12
Correlation between osteoporotic fracture risk in Brazilian postmenopausal women calculated using the FRAX with and without the inclusion of bone densitometry data. ( 27067597 )
2016
13
The osteoporotic fracture prevention program in rural areas (OFRA): a protocol for a cluster-randomized health care fund driven intervention in a routine health care setting. ( 27821102 )
2016
14
The use of augmentation techniques in osteoporotic fracture fixation. ( 27338226 )
2016
15
Osteoporotic fracture fixation - a biomechanical perspective. ( 27338220 )
2016
16
Association of circulating dipeptidyl-peptidase 4 levels with osteoporotic fracture in postmenopausal women. ( 27866216 )
2016
17
Inhibition of Midkine Augments Osteoporotic Fracture Healing. ( 27410432 )
2016
18
Finger Fractures as an Early Manifestation of Primary Hyperparathyroidism Among Young Patients: A Case Report of a 30-Year-Old Male With Recurrent Osteoporotic Fractures. ( 27196476 )
2016
19
Economic Burden of Osteoporotic Fracture of the Elderly in South Korea: A National Survey. ( 27881257 )
2016
20
Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients: A Population-based Longitudinal Cohort Study. ( 27958221 )
2016
21
Objectively-Verified Parental Non-Hip Major Osteoporotic Fractures and Offspring Osteoporotic Fracture Risk: A Population-Based Familial Linkage Study. ( 27859612 )
2016
22
Prediction of Future Osteoporotic Fracture Occurrence by Genetic Profiling: A 6-Year Follow-Up Observational Study. ( 26756118 )
2016
23
Use of teriparatide in osteoporotic fracture patients. ( 26768289 )
2016
24
Automatic Estimation of Osteoporotic Fracture Cases by Using Ensemble Learning Approaches. ( 26660692 )
2016
25
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model. ( 26723576 )
2016
26
Low-magnitude high-frequency vibration enhanced mesenchymal stem cell recruitment in osteoporotic fracture healing through the SDF-1/CXCR4 pathway. ( 27215741 )
2016
27
How Good is Our Best Guess? Clinical Application of the WHO FRAX Tool in Osteoporotic Fracture Risk Determination and Treatment Decisions. ( 27038319 )
2016
28
Development of a Korean Fracture Risk Score (KFRS) for Predicting Osteoporotic Fracture Risk: Analysis of Data from the Korean National Health Insurance Service. ( 27399597 )
2016
29
DUAL-ENERGY X-RAY ABSORPTIOMETRY AND CALCULATED FRAX RISK SCORES MAY UNDERESTIMATE OSTEOPOROTIC FRACTURE RISK IN VITAMIN D-DEFICIENT VETERANS WITH HIV INFECTION. ( 26684149 )
2016
30
Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review. ( 27055104 )
2016
31
Predicting the 10-year risk of hip and major osteoporotic fracture in rheumatoid arthritis and in the general population: an independent validation and update of UK FRAX without bone mineral density. ( 26984006 )
2016
32
Implementation of Models of Care for secondary osteoporotic fracture prevention and orthogeriatric Models of Care for osteoporotic hip fracture. ( 27886945 )
2016
33
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. ( 26733130 )
2016
34
Main differences in osteoporotic fracture models: which should I use? ( 26768283 )
2016
35
Calcium status may modify the association of magnesium and potassium intake with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort study. ( 26728693 )
2016
36
Decreased Plasma Levels of Sclerostin But Not Dickkopf-1 are Associated with an Increased Prevalence of Osteoporotic Fracture and Lower Bone Mineral Density in Postmenopausal Korean Women. ( 27289555 )
2016
37
A meta-analysis of breastfeeding and osteoporotic fracture risk in the females. ( 27577724 )
2016
38
Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study. ( 26981519 )
2016
39
Trends in vertebroplasty and kyphoplasty after thoracolumbar osteoporotic fracture: A large database study from 2005 to 2012. ( 27047226 )
2015
40
An assessment system for evaluating the severity of thoracolumbar osteoporotic fracture and its clinical application: A retrospective study of 381 cases. ( 26383865 )
2015
41
Relationship between Decrease in Serum Sodium Level and Bone Mineral Density in Osteoporotic Fracture Patients. ( 25774359 )
2015
42
Cement augmentation of implants-no general cure in osteoporotic fracture treatment. A biomechanical study on non-displaced femoral neck fractures. ( 26177609 )
2015
43
Diagnostic Test of a Scoring System for Frailty Syndrome in the Elderly According to Cardiovascular Health Study, Study of Osteoporotic Fracture and Comprehensive Geriatric Assessment Based Frailty Index Compared with Frailty Index 40 Items. ( 26586383 )
2015
44
Slightly focused high-energy shockwave therapy: a potential adjuvant treatment for osteoporotic fracture. ( 26131077 )
2015
45
Osteoporotic fractures in patients with untreated hyperprolactinemia vs. those taking dopamine agonists: A systematic review and meta-analysis. ( 26921574 )
2015
46
Osteoporotic Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research. ( 26713308 )
2015
47
Degree of Trauma Differs for Major Osteoporotic Fracture Events in Older Men Versus Older Women. ( 26178795 )
2015
48
Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population. ( 25658585 )
2015
49
Osteoporotic fracture rate among women with at least 1 year of adherence to osteoporosis treatment. ( 25708648 )
2015
50
Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adults: the Age, Gene/Environment Susceptibility Study. ( 25787995 )
2015

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

GO Terms for Osteoporotic Fracture

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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