MCID: OST097
MIFTS: 40

Osteoporotic Fracture malady

Bone diseases category

Summaries for Osteoporotic Fracture

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34MalaCards
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MalaCards: Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteoarthritis. An important gene associated with Osteoporotic Fracture is CER1 (cerberus 1, DAN family BMP antagonist), and among its related pathways are TGF-beta Signaling Pathway and Wnt Signaling Pathway. The compounds calcium carbonate and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are growth/size/body and limbs/digits/tail.

Aliases & Classifications for Osteoporotic Fracture

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Sources:
32LifeMap Discoveryā„¢, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoporotic fracture 32 46
osteoporotic fractures 63


Related Diseases for Osteoporotic Fracture

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.8BGLAP, IBSP, PTH, SOST, COL1A1
2osteoarthritis30.6COL1A1, IBSP, BGLAP
3osteonecrosis30.3BGLAP
4breast cancer10.4
5cervicitis10.3
6postural hypotension10.3
7fatty liver disease10.1
8cervical dystonia10.1
9spinal stenosis10.1
10prolactinoma10.1
11irritable bowel syndrome10.1
12anorexia nervosa10.1
13hyperprolactinemia10.1
14empty sella syndrome10.1
15parkinson's disease10.1
16arthritis10.1
17cerebrovascular disease10.1
18diabetes mellitus10.1
19dystonia10.1
20liver disease10.1
21rheumatoid arthritis10.1
22type 2 diabetes mellitus10.1
23back pain10.1
24spinal cord injury10.1
25osteonecrosis of the jaw10.1
26osteosclerosis10.0PTH, SOST
27dentinogenesis imperfecta10.0IBSP, COL1A1
28osteogenesis imperfecta type i10.0BGLAP, COL1A1
29pseudohypoparathyroidism type 1b10.0BGLAP, PTH
30idiopathic juvenile osteoporosis10.0COL1A1, BGLAP
31osteitis fibrosa10.0PTH, BGLAP
32pseudohypoparathyroidism10.0PTH, BGLAP
33renal osteodystrophy10.0PTH, BGLAP
34hypophosphatemia10.0PTH, BGLAP
35hypoparathyroidism10.0PTH, BGLAP
36secondary hyperparathyroidism of renal origin10.0BGLAP, PTH
37osteomalacia10.0BGLAP, PTH
38rickets10.0PTH, BGLAP
39fibrous dysplasia10.0IBSP, BGLAP
40ankylosing spondylitis10.0PTH, BGLAP
41goiter10.0BGLAP, PTH
42hyperparathyroidism10.0PTH, BGLAP
43bone carcinoma10.0BGLAP, IBSP
44metabolic acidosis10.0PTH, BGLAP
45hypercalcemia10.0PTH, BGLAP
46hyperostosis10.0COL1A1, SOST, BGLAP
47hyperthyroidism10.0PTH, BGLAP
48periodontal disease10.0IBSP, BGLAP
49primary hyperparathyroidism9.9BGLAP, IBSP, PTH
50osteogenesis imperfecta9.9COL1A1, IBSP, BGLAP

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to osteoporotic fracture

Symptoms for Osteoporotic Fracture

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Drugs & Therapeutics for Osteoporotic Fracture

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Osteoporotic Fracture

Drug clinical trials:

Search ClinicalTrials for Osteoporotic Fracture

Search NIH Clinical Center for Osteoporotic Fracture

Search CenterWatch for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

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Anatomical Context for Osteoporotic Fracture

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34MalaCards
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MalaCards organs/tissues related to Osteoporotic Fracture:

34
Bone, Breast, Testes, Liver, Spinal cord, Heart

Animal Models for Osteoporotic Fracture or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Osteoporotic Fracture:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0COL1A1, CER1, SOST, PTH, IBSP
2MP:00053717.7IBSP, PTH, SOST, CER1, COL1A1
3MP:00053907.5COL1A1, WNT16, CER1, SOST, PTH, IBSP

Publications for Osteoporotic Fracture

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53PubMed
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Articles related to Osteoporotic Fracture:

(show top 50)    (show all 275)
idTitleAuthorsYear
1
Performance of risk assessment instruments for predicting osteoporotic fracture risk: a systematic review. (24105431)
2014
2
Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data. (24345885)
2013
3
A glimpse from the past: osteoporosis and osteoporotic fractures in a portuguese identified skeletal sample. (24131908)
2013
4
High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women. (23023015)
2013
5
What was your fracture risk evaluated by FRAXAr the day before your osteoporotic fracture? (23114631)
2013
6
Standard radiography: untapped potential in the assessment of osteoporotic fracture risk. (23187729)
2013
7
Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. (24065012)
2013
8
Role of medicinal plants and natural products on osteoporotic fracture healing. (22973405)
2012
9
Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. (22619194)
2012
10
Clinical characteristics, bone mineral density and non-vertebral osteoporotic fracture outcomes among post-menopausal U.S. South Asian Women. (22921875)
2012
11
FRAXAr probabilities and risk of major osteoporotic fracture in France. (22179418)
2012
12
Association between nonalcoholic fatty liver disease (NAFLD) and osteoporotic fracture in middle-aged and elderly Chinese. (22466338)
2012
13
Three-year experience with combined treatment with alendronate and alfacalcidol in Japanese patients with severe bone loss and osteoporotic fracture. (21753888)
2011
14
Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(Ar): a population-based report from CAMOS. (21723768)
2011
15
Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. (20094707)
2010
16
Comparison of a new minimum contact locking plate and the limited contact dynamic compression plate in an osteoporotic fracture model. (19089425)
2009
17
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. (19841454)
2009
18
Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. (18974918)
2009
19
Osteoporotic fracture risk in elderly women: estimation with quantitative heel US and clinical risk factors. (18483227)
2008
20
Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS). (17499570)
2007
21
Measures of renal function, BMD, bone loss, and osteoporotic fracture in older adults: the Rancho Bernardo study. (17059370)
2007
22
The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. (17555504)
2007
23
Digital x-ray radiogrammetry identifies women at risk of osteoporotic fracture: results from a prospective study. (16868669)
2006
24
Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. (16391245)
2006
25
Osteoporotic fractures and vitamin D deficiency. (16820826)
2006
26
Review: developmental origins of osteoporotic fracture. (16331359)
2006
27
Bone tissue compositional differences in women with and without osteoporotic fracture. (16901772)
2006
28
Low femoral bone mineral density and quantitative ultrasound are risk factors for new osteoporotic fracture and total and cardiovascular mortality: a 5-year population-based study of Brazilian elderly women. (16510866)
2006
29
Severity of obstructive airway disease and risk of osteoporotic fracture. (15863646)
2005
30
Thoracic osteoporotic fracture without upper back pain. (15314538)
2004
31
Fracture risk following an osteoporotic fracture. (14691617)
2004
32
Percutaneous vertebroplasty for osteoporotic fracture: preliminary experience at Middlemore Hospital. (15477925)
2004
33
Vertebral assessment using dual-energy X-ray absorptiometry for osteoporotic fracture risk assessment. (15651136)
2004
34
Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. (12810179)
2003
35
The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population. (12730754)
2003
36
Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. (12534843)
2003
37
Is vitamin A consumption a risk factor for osteoporotic fracture? (15018484)
2003
38
Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies. (11792594)
2002
39
Does high intake of vitamin A pose a risk for osteoporotic fracture? (11903019)
2002
40
Reconsidering the effects of antiresorptive therapies in reducing osteoporotic fracture. (11760829)
2001
41
Exercise for prevention of osteoporotic fracture. (11769785)
2001
42
Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. (10752709)
2000
43
Hormonal and biochemical parameters and osteoporotic fractures in elderly men. (10893691)
2000
44
Mortality after all major types of osteoporotic fracture in men and women: an observational study. (10093980)
1999
45
Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group. (9661081)
1998
46
Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. (9535665)
1998
47
Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group. (9669990)
1998
48
Water fluoridation and osteoporotic fracture. (8897754)
1996
49
Calcium intake in the osteoporotic fracture context: introduction. (2053569)
1991
50
Prolactinoma in a middle-aged man with an osteoporotic fracture. (2763547)
1989

Variations for Osteoporotic Fracture

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Expression for genes affiliated with Osteoporotic Fracture

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for genes affiliated with Osteoporotic Fracture

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Sources:
51PathCards, 58SinoBiological, 39NCBI BioSystems Database, 55R&D Systems, 31KEGG, 61Thomson Reuters
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Compounds for genes affiliated with Osteoporotic Fracture

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1calcium carbonate469.5PTH, BGLAP
2pamidronate46 52 1211.5PTH, BGLAP
3alendronate46 52 1211.4PTH, BGLAP
4glycosaminoglycan469.4IBSP, COL1A1
5ibandronate46 1210.4BGLAP, IBSP
6alizarin469.4IBSP, BGLAP
725-hydroxyvitamin d469.4PTH, BGLAP
8phosphorus469.4BGLAP, PTH
9chitosan469.3IBSP, BGLAP
10titanium469.3BGLAP, IBSP
11zoledronic acid469.3IBSP, BGLAP
12estrone46 30 25 1212.2PTH, BGLAP
13ibmx46 62 3011.2IBSP, PTH
14hydroxyapatite469.2IBSP, BGLAP
15thyroxine46 2510.1PTH, BGLAP
16thymidine46 2510.0COL1A1, PTH, IBSP
17deoxypyridinoline468.9PTH, IBSP, BGLAP
18simvastatin46 52 62 30 25 1213.8COL1A1, BGLAP
19estradiol46 25 1210.8BGLAP, IBSP, PTH
20creatinine468.7BGLAP, IBSP, PTH
21arginine468.6COL1A1, PTH, BGLAP
22hydroxyproline46 25 1210.4COL1A1, PTH, IBSP, BGLAP
23procollagen468.4BGLAP, IBSP, PTH, COL1A1
241,25 dihydroxy vitamin d3468.4BGLAP, IBSP, PTH, COL1A1
25pge2468.3COL1A1, PTH, IBSP, BGLAP
26dexamethasone46 52 30 1211.3BGLAP, IBSP, PTH, COL1A1
27vegf468.3BGLAP, IBSP, PTH, COL1A1
28cysteine468.0BGLAP, IBSP, SOST, CER1, COL1A1
29vitamin d467.9BGLAP, IBSP, PTH, SOST, COL1A1
30estrogen467.9BGLAP, IBSP, PTH, SOST, COL1A1
31calcium46 52 25 1210.8BGLAP, IBSP, PTH, SOST, COL1A1

GO Terms for genes affiliated with Osteoporotic Fracture

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17Gene Ontology
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Cellular components related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2IBSP, PTH, CER1, WNT16, COL1A1, BGLAP
2extracellular spaceGO:0056157.1COL1A1, WNT16, CER1, SOST, PTH, BGLAP

Biological processes related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of BMP signaling pathwayGO:0305149.8CER1, SOST
2Wnt signaling pathwayGO:0160559.6WNT16, SOST
3bone mineralizationGO:0302829.5BGLAP, CER1
4response to vitamin DGO:0332809.3PTH, BGLAP
5ossificationGO:0015039.3IBSP, SOST
6response to mechanical stimulusGO:0096129.3SOST, BGLAP
7cellular response to growth factor stimulusGO:0713639.1BGLAP, IBSP
8osteoblast differentiationGO:0016499.1COL1A1, BGLAP
9skeletal system developmentGO:0015018.8COL1A1, PTH, BGLAP
10response to ethanolGO:0454718.8PTH, BGLAP

Products for genes affiliated with Osteoporotic Fracture

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Osteoporotic Fracture

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet