MCID: OST097
MIFTS: 41

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 51
Osteoporotic Fractures 69

Classifications:



External Ids:

UMLS 69 C0521170

Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteonecrosis and osteoporosis. An important gene associated with Osteoporotic Fracture is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and AGE-RAGE signaling pathway in diabetic complications. The drugs Teriparatide and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and prostate, and related phenotypes are growth/size/body region and integument

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 29.4 MTHFR TNFRSF11B
2 osteoporosis 29.3 COL1A1 ESR1 IL6 TNFRSF11B
3 cerebrovascular disease 29.3 IL6 MTHFR
4 periodontitis 29.1 IL6 TNFRSF11B
5 periodontal disease 29.1 IL6 TNFRSF11B
6 bone mineral density quantitative trait locus 18 11.7
7 bone mineral density quantitative trait locus 15 10.4
8 bone mineral density quantitative trait locus 8 10.4
9 aging 10.3
10 pelvic organ prolapse 10.2 COL1A1 ESR1
11 osteoarthritis with mild chondrodysplasia 10.1
12 osteoarthritis 10.1
13 sudden sensorineural hearing loss 10.1 IL6 MTHFR
14 gastroschisis 10.1 IL6 MTHFR
15 vaginitis 10.1 ESR1 IL6
16 endometrial disease 10.1 ESR1 IL6
17 ischemic heart disease 10.0 IL6 MTHFR
18 encephalomalacia 10.0 IL6 MTHFR
19 central retinal vein occlusion 10.0 IL6 MTHFR
20 hematopoietic stem cell transplantation 10.0 IL6 MTHFR
21 endometritis 10.0 ESR1 IL6
22 retinal vein occlusion 10.0 IL6 MTHFR
23 breast carcinoma in situ 10.0 ESR1 IL6
24 bone cancer 10.0 COL1A1 IL6
25 placenta disease 10.0 IL6 MTHFR
26 female reproductive system disease 10.0 ESR1 IL6
27 arthritis 10.0
28 rheumatoid arthritis 10.0
29 nutritional deficiency disease 10.0 IL6 MTHFR
30 reproductive system disease 10.0 ESR1 IL6
31 cerebral palsy 10.0 IL6 MTHFR
32 arteries, anomalies of 9.9 IL6 MTHFR
33 osteogenesis imperfecta, type i 9.9 COL1A1 TNFRSF11B
34 body mass index quantitative trait locus 8 9.9
35 body mass index quantitative trait locus 18 9.9
36 postural hypotension 9.9
37 hyperprolactinemia 9.9
38 ring chromosome y syndrome 9.9
39 body mass index quantitative trait locus 4 9.9
40 body mass index quantitative trait locus 10 9.9
41 cervicitis 9.9
42 diabetes mellitus 9.9
43 body mass index quantitative trait locus 7 9.9
44 body mass index quantitative trait locus 11 9.9
45 body mass index quantitative trait locus 12 9.9
46 body mass index quantitative trait locus 9 9.9
47 body mass index quantitative trait locus 14 9.9
48 atrial fibrillation 9.9
49 hyperostosis 9.9 COL1A1 TNFRSF11B
50 hellp syndrome 9.9 IL6 MTHFR

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

MGI Mouse Phenotypes related to Osteoporotic Fracture:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.77 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
2 integument MP:0010771 9.62 ESR1 IL6 MTHFR COL1A1
3 limbs/digits/tail MP:0005371 9.56 COL1A1 ESR1 MTHFR TNFRSF11B
4 mortality/aging MP:0010768 9.55 COL1A1 ESR1 IL6 MTHFR TNFRSF11B
5 reproductive system MP:0005389 9.26 COL1A1 ESR1 IL6 MTHFR
6 skeleton MP:0005390 9.02 COL1A1 ESR1 IL6 MTHFR TNFRSF11B

Drugs & Therapeutics for Osteoporotic Fracture

Drugs for Osteoporotic Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2 52232-67-4 16133850
2
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
3
Zoledronic acid Approved Phase 4,Phase 3 118072-93-8 68740
4
Etidronic acid Approved Phase 4,Phase 3 2809-21-4, 7414-83-7 3305
5
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
6
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
7
Denosumab Approved Phase 4,Phase 3 615258-40-7
8
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
9
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
10 Micronutrients Phase 4,Phase 3,Phase 2
11 Trace Elements Phase 4,Phase 3,Phase 2
12 Vitamins Phase 4,Phase 3,Phase 2
13 Ergocalciferols Phase 4,Phase 3,Phase 2
14 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
15 Calcium, Dietary Phase 4,Phase 3,Phase 2
16 Risedronate Sodium Phase 4,Phase 3 115436-72-1
17 calcium channel blockers Phase 4,Phase 3
18 Central Nervous System Depressants Phase 4
19 Sodium Channel Blockers Phase 4
20 Anesthetics Phase 4,Phase 3,Phase 2
21 Anesthetics, Local Phase 4
22 Diphosphonates Phase 4,Phase 3,Phase 2
23 Diuretics, Potassium Sparing Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 2
25 Anti-Arrhythmia Agents Phase 4
26 Hypoglycemic Agents Phase 4
27 Liver Extracts Phase 4
28 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2
29 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2
30
Tamoxifen Approved Phase 3 10540-29-1 2733526
31
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
32
Alendronate Approved Phase 3 121268-17-5, 66376-36-1 2088
33
Calcium Carbonate Approved, Investigational Phase 3 471-34-1
34
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
35
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
36
Flutamide Approved, Investigational Phase 3 13311-84-7 3397
37
Goserelin Approved Phase 3 65807-02-5 5311128 47725
38
Bicalutamide Approved Phase 3 90357-06-5 2375 56069
39
Buserelin Approved, Investigational Phase 3 57982-77-1
40
Leuprolide Approved, Investigational Phase 3 53714-56-0 657181 3911
41
Cholecalciferol Approved, Nutraceutical Phase 3 67-97-0 10883523 5280795 6221
42
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
43 Androgens Phase 3
44 Hormone Antagonists Phase 3,Phase 2
45 Hormones Phase 3,Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
47 Selective Estrogen Receptor Modulators Phase 3
48 Steroid Synthesis Inhibitors Phase 3
49 Gastrointestinal Agents Phase 3
50 Vasodilator Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 133)

# Name Status NCT ID Phase Drugs
1 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
2 Vertebroplasty Compared With a Sham-procedure for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01537770 Phase 4
3 Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting Completed NCT01847898 Phase 4
4 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
5 Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) Recruiting NCT02589600 Phase 4 Zoledronic acid
6 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Recruiting NCT02148848 Phase 4 Risedronate
7 Preventing Osteoporosis Using Denosumab Recruiting NCT02753283 Phase 4 denosumab;Placebo
8 Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer Unknown status NCT00957606 Phase 3
9 Early Rehabilitation After Hip Fracture Unknown status NCT00133640 Phase 3 cholecalciferol
10 Secondary Prevention of Osteoporotic Fractures in Residents of Long-Term Care Facilities Completed NCT00280943 Phase 2, Phase 3
11 BONDIR Study: A Study of Intravenous Bonviva (Ibandronate) After Recent Vertebral Osteoporotic Fracture in Patients With Osteoporosis. Completed NCT00493623 Phase 3 Placebo;ibandronate [Bonviva/Boniva]
12 Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture Completed NCT00046254 Phase 3 Zoledronic Acid
13 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis Completed NCT00068822 Phase 3
14 Secondary Prevention of Osteoporosis Completed NCT00421343 Phase 3 alendronate with cholecalciferol;calcium carbonate with cholecalciferol
15 Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer Completed NCT00859703 Phase 3 Risedronate;Placebo
16 Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing Completed NCT01293721 Phase 2, Phase 3
17 Low-magnitude High-frequency Vibration Study on Fracture Rate in Community Elderly Completed NCT00973167 Phase 2, Phase 3
18 The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis Completed NCT00252421 Phase 3 Nitroglycerin ointment 15 mg/day daily for 24 month;Placebo ointment daily for 24 month
19 BREAST CANCER AND EXERCISE Completed NCT00639210 Phase 3
20 Calcium and Vitamin D Malnutrition in Elderly Women Completed NCT00352170 Phase 3
21 Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy Completed NCT00053898 Phase 3 anastrozole;tamoxifen citrate
22 Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial CAN-NCIC-MA27 Completed NCT00354302 Phase 3 alendronate sodium;calcium gluconate;risedronate sodium
23 Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis Completed NCT00670319 Phase 3 Raloxifene HCL;Raloxifene HCL;Placebo
24 Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures Recruiting NCT01896011 Phase 3
25 Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Active, not recruiting NCT00697463 Phase 2, Phase 3 Teriparatide (PTH 1-34)
26 Different Durations of Adjuvant Anastrozole Therapy After 2 to 3 Years Tamoxifen Therapy in Breast Cancer Active, not recruiting NCT00301457 Phase 3 Anastrozole
27 Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer Active, not recruiting NCT01546987 Phase 3 bicalutamide;buserelin;flutamide;goserelin acetate;leuprolide acetate;orteronel;triptorelin
28 Oligopin Supplementation and Bone Turnover Markers and Antioxidant Changes in Postmenopausal Osteopenic Women Enrolling by invitation NCT03260803 Phase 3 Oligopin;Placebo
29 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet. Enrolling by invitation NCT03027557 Phase 3 Cinacalcet 30 mg Tablet;Denosumab Inj 60 mg/ml
30 Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy Terminated NCT01512446 Phase 3 Alendronate;Placebo
31 Effects of Whole Body Vibration on Postmenopausal Risk-factors in Elderly Women Terminated NCT00667667 Phase 3
32 Evaluation of the Proximal Femoral Nail Antirotation With Cement Augmentation in Osteoporotic Femoral Neck Fractures Unknown status NCT01235169 Phase 1, Phase 2
33 Phase 2a Study on Intravenous Infusion of Autologous Osteoblastic Cells in Severe Osteoporosis Unknown status NCT02061995 Phase 2 PREOB® Intravenous Infusion
34 Effectiveness of Physiotherapy for Osteoporotic Spinal Fracture Completed NCT00638768 Phase 2
35 Can Parathyroid Hormone Injections Reverse Glucocorticoid-induced Osteoporosis Completed NCT00004993 Phase 2 Parathyroid hormone (hPTH 1-34)
36 Shock Wave Therapy for Osteoporosis Completed NCT02630381 Phase 2
37 Study Evaluating Changes In Bone Mineral Density (BMD), And Safety Of Rhbmp-2/CPM In Subjects With Decreased BMD Completed NCT00752557 Phase 2 rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy);rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy);bisphosphonates, calcium, and vitamin D
38 Tocilizumab for Patients With Giant Cell Arteritis Completed NCT01450137 Phase 2 Tocilizumab + Glucocorticoids (GCs);Placebo + Glucocorticoids (GCs)
39 Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome Completed NCT01051778 Phase 2 enoxaparin 40mg plus low dose aspirin;Heparin calcium5,000 U twice daily plus low dose aspirin
40 PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial Recruiting NCT02972424 Phase 2 Teriparatide Prefilled Syringe;Placebo
41 Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts Terminated NCT01532076 Phase 2
42 Gene-Polymorphies in the P2X7 Gene in Patients With Osteoporotic Fractures Unknown status NCT00293189
43 Secondary Fracture Prevention in Patients Who Suffered From Osteoporotic Fracture Unknown status NCT02223572
44 Osteoporosis and Knee Insufficiency Fracture Unknown status NCT02332681
45 RCT: Added Value of Coordinator for the Management of Hip Fracture Patients Unknown status NCT01785381
46 Prevalence and Predictors of Osteoporosis in the Beijing's Urban Population Unknown status NCT01476150
47 Osteoprosis in Type 2 Diabetic Patients- a Cohort Study Unknown status NCT01846533
48 Osteoporosis Coordinator for Low Volume Community Hospitals Unknown status NCT00511693
49 Study of Different Types of Backache in Groups of Patients With Different Diagnoses of Degenerative Diseases Unknown status NCT02402335
50 Development of Non-invasive Method for Quantifying Vitamin D Levels in the Body Using Spectroscopy Unknown status NCT01912898

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

38
Bone, Breast, Prostate, Bone Marrow, Liver, Heart, Neutrophil

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 415)
# Title Authors Year
1
The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. ( 29304151 )
2018
2
Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study. ( 29079514 )
2018
3
Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS. ( 29376552 )
2018
4
Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing. ( 29216500 )
2018
5
Hepatitis C virus infection and risk of osteoporotic fracture: A systematic review and meta-analysis. ( 29322660 )
2018
6
The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 29067485 )
2018
7
Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture. ( 29329765 )
2018
8
Meta-analysis of hypertension and osteoporotic fracture risk in women and men: response to comments by RodrA-guez et al. ( 28986610 )
2018
9
Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT. ( 29314261 )
2018
10
Development of a risk assessment tool for osteoporotic fracture prevention: A claims data approach. ( 29421456 )
2018
11
Comments on Li et al.: Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28986611 )
2018
12
International Classification of Diseases (ICD)-coded obesity predicts risk of incident osteoporotic fracture. ( 29216254 )
2017
13
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease. ( 28530467 )
2017
14
The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exercise to reduce risk of osteoporotic fracture in older men with low bone mass. ( 28611110 )
2017
15
Organic Gallium Treatment Improves Osteoporotic Fracture Healing Through Affecting the OPG/RANKL Ratio and Expression of Serum Inflammatory Cytokines in Ovariectomized Rats. ( 28836172 )
2017
16
A Model for Assessing the Clinical and Economic Benefits of Bone-forming Agents for Reducing Fractures in Postmenopausal Women at High, Near-term Risk of Osteoporotic Fracture. ( 28629610 )
2017
17
Efficacy of Kirschner-wires and tension band in hip arthroplasty for aged patients with unstable intertrochanteric osteoporotic fracture: A 2-to-11-year follow-up. ( 28072698 )
2017
18
Relationship between vitamin D, osteoporotic fracture and falls. ( 28625513 )
2017
19
Custom-made titanium 3D printed interbody cages for treatment of osteoporotic fracture related spinal deformity. ( 29223522 )
2017
20
Cross-cultural validation of the Modified Falls Efficacy Scale in Serbian community-dwelling women at risk for osteoporotic fracture. ( 29088014 )
2017
21
The application of the FRIDEX calibration of the FRAX tool to determine the absolute risk of osteoporotic fracture among Spanish women. ( 29221875 )
2017
22
Cortical Fractal Analysis and Collagen Crosslinks Content in Femoral Neck After Osteoporotic Fracture in Postmenopausal Women: Comparison with Osteoarthritis. ( 29249023 )
2017
23
An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8). ( 28711604 )
2017
24
The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis. ( 28326300 )
2017
25
Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. ( 28587685 )
2017
26
Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: a population-based study in a tuberculosis-endemic area. ( 28331966 )
2017
27
Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population: A population-based cohort study in Taiwan. ( 29145244 )
2017
28
High incidence of vertebral osteoporotic fracture within the first year after liver transplantation. ( 28516878 )
2017
29
Evaluating osteoporotic fracture risk with the Fracture Risk Assessment Tool in Chinese patients with rheumatoid arthritis. ( 28471962 )
2017
30
Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. ( 28451733 )
2017
31
Added clinical use of trabecular bone score to BMD for major osteoporotic fracture prediction in older Chinese people: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 27725999 )
2017
32
Do we need bone mineral density to estimate osteoporotic fracture risk? A 10-year prospective multicentre validation study. ( 29018567 )
2017
33
Getting Osteoporotic Fracture Risk Into Vascular Structure and Functiona88- Do You Know Your FRAX(Ar) Score? ( 28331114 )
2017
34
Validity of major osteoporotic fracture diagnosis codes in the Clinical Data Analysis and Reporting System in Hong Kong. ( 28371079 )
2017
35
Effect of HBM Rehabilitation Exercises on Depression, Anxiety and Health Belief in Elderly Patients with Osteoporotic Fracture. ( 29197204 )
2017
36
The Role of Exercises in Osteoporotic Fracture Prevention and Current Care Gaps. Where Are We Now? Recent Updates. ( 28786812 )
2017
37
Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28447105 )
2017
38
Increased detection of genetic loci associated with risk predictors of osteoporotic fracture using a pleiotropic cFDR method. ( 28373146 )
2017
39
Adherence to osteoporosis pharmacotherapy one year after osteoporotic fracture - a Swiss trauma center secondary prevention project. ( 28695555 )
2017
40
FRAX-based Estimates of 10-year Probability of Hip and Major Osteoporotic Fracture Among Adults Aged 40 and Over: United States, 2013 and 2014. ( 28459415 )
2017
41
Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011. ( 28642857 )
2017
42
Risk of Osteoporotic Fracture After Steroid Injections in Patients With Medicare. ( 29099886 )
2017
43
Prevalence and incidence of osteoporotic fractures in patients on long-term glucocorticoid treatment for rheumatic diseases: the Glucocorticoid Induced OsTeoporosis TOol (GIOTTO) study. ( 28535619 )
2017
44
Economic Burden of Osteoporotic Fracture of the Elderly in South Korea: A National Survey. ( 27881257 )
2016
45
Metabolic syndrome and osteoporotic fracture: a population-based study in China. ( 27233999 )
2016
46
Implementation of Models of Care for secondary osteoporotic fracture prevention and orthogeriatric Models of Care for osteoporotic hip fracture. ( 27886945 )
2016
47
Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture. ( 27294077 )
2016
48
Perceived stress and risk of any osteoporotic fracture. ( 26786258 )
2016
49
Finger Fractures as an Early Manifestation of Primary Hyperparathyroidism Among Young Patients: A Case Report of a 30-Year-Old Male With Recurrent Osteoporotic Fractures. ( 27196476 )
2016
50
Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients: A Population-based Longitudinal Cohort Study. ( 27958221 )
2016

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 COL1A1 IL6
2 11.32 COL1A1 IL6
3 11.24 COL1A1 IL6
4 10.65 IL6 MTHFR
5 10.45 COL1A1 IL6 TNFRSF11B
6 10.1 COL1A1 TNFRSF11B

GO Terms for Osteoporotic Fracture

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 COL1A1 ESR1 IL6
2 platelet activation GO:0030168 9.43 COL1A1 IL6
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.4 ESR1 IL6
4 response to estradiol GO:0032355 9.37 COL1A1 ESR1
5 response to nutrient GO:0007584 9.26 COL1A1 TNFRSF11B
6 response to estrogen GO:0043627 9.16 ESR1 TNFRSF11B
7 response to drug GO:0042493 9.13 COL1A1 MTHFR TNFRSF11B
8 negative regulation of bone resorption GO:0045779 8.62 IL6 TNFRSF11B

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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