MCID: OST097
MIFTS: 27

Osteoporotic Fracture

Categories: Bone diseases

Aliases & Classifications for Osteoporotic Fracture

MalaCards integrated aliases for Osteoporotic Fracture:

Name: Osteoporotic Fracture 52
Osteoporotic Fractures 69

Classifications:



Summaries for Osteoporotic Fracture

MalaCards based summary : Osteoporotic Fracture, also known as osteoporotic fractures, is related to bone mineral density qtl18, osteoporosis and osteoporosis. An important gene associated with Osteoporotic Fracture is COL1A1 (Collagen Type I Alpha 1 Chain). The drugs Calcium Carbonate and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate.

Related Diseases for Osteoporotic Fracture

Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
id Related Disease Score Top Affiliating Genes
1 bone mineral density qtl18, osteoporosis 11.1
2 osteoporosis 10.4
3 osteoarthritis 10.0
4 rheumatoid arthritis 9.9
5 breast cancer 9.9
6 arthritis 9.9
7 hyperprolactinemia 9.8
8 atrial fibrillation 9.8
9 cervicitis 9.8
10 postural hypotension 9.8
11 systemic lupus erythematosus 9.7
12 prostate cancer 9.7
13 obesity 9.7
14 anorexia nervosa 9.7
15 insulin-like growth factor i 9.7
16 liver disease 9.7
17 osteonecrosis 9.7
18 spinal cord injury 9.7
19 spinal stenosis 9.7
20 cervical dystonia 9.7
21 glucocorticoid-induced osteoporosis 9.7
22 hyperparathyroidism 9.7
23 prostatitis 9.7
24 rheumatic disease 9.7
25 periodontal disease 9.7
26 empty sella syndrome 9.7
27 tuberculosis 9.7
28 dystonia 9.7
29 cerebrovascular disease 9.7
30 periodontitis 9.7
31 lupus erythematosus 9.7
32 fatty liver disease 9.7
33 irritable bowel syndrome 9.7
34 back pain 9.7
35 osteonecrosis of the jaw 9.7

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to Osteoporotic Fracture

Symptoms & Phenotypes for Osteoporotic Fracture

Drugs & Therapeutics for Osteoporotic Fracture

Drugs for Osteoporotic Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 137)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved Phase 4,Phase 3 471-34-1
2
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2 52232-67-4 16133850
3
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
4
Zoledronic acid Approved Phase 4,Phase 3 118072-93-8 68740
5
Etidronic acid Approved Phase 4,Phase 3 7414-83-7, 2809-21-4 3305
6
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
7
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
8
Denosumab Approved Phase 4,Phase 3 615258-40-7
9
Menthol Approved Phase 4 2216-51-5 16666
10
Tranexamic Acid Approved Phase 4 1197-18-8 5526
11
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
12
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
13 Risedronate Sodium Phase 4,Phase 3 115436-72-1
14 Analgesics Phase 4,Phase 3,Phase 2
15 Micronutrients Phase 4,Phase 3,Phase 2
16 Gastrointestinal Agents Phase 4,Phase 3
17 Anesthetics Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2
19 Trace Elements Phase 4,Phase 3,Phase 2
20 Anesthetics, Local Phase 4,Phase 3
21 Hormones Phase 4,Phase 3,Phase 2
22 Antacids Phase 4,Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
25 Ergocalciferols Phase 4,Phase 3,Phase 2
26 Vitamins Phase 4,Phase 3,Phase 2
27 Polymethyl Methacrylate Phase 4,Phase 3
28 Anti-Ulcer Agents Phase 4,Phase 3
29 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
30 Calcium, Dietary Phase 4,Phase 3,Phase 2
31 calcium channel blockers Phase 4,Phase 3
32 glucocorticoids Phase 4,Phase 2
33 Central Nervous System Depressants Phase 4,Phase 3
34 Sodium Channel Blockers Phase 4,Phase 3
35 Diphosphonates Phase 4,Phase 3,Phase 2
36 Diuretics, Potassium Sparing Phase 4,Phase 3
37 Vasodilator Agents Phase 4,Phase 3
38 Anti-Arrhythmia Agents Phase 4,Phase 3
39 Hypoglycemic Agents Phase 4
40 Anticonvulsants Phase 4
41 Protective Agents Phase 4,Phase 3
42 Liver Extracts Phase 4
43 Coagulants Phase 4,Phase 2
44 Hemostatics Phase 4,Phase 2
45 Antifibrinolytic Agents Phase 4
46 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2
47 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2
48 Calamus Nutraceutical Phase 4
49
Tamoxifen Approved Phase 3 10540-29-1 2733526
50
Iron Approved Phase 3 7439-89-6 23925

Interventional clinical trials:

(show top 50) (show all 182)

id Name Status NCT ID Phase Drugs
1 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
2 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
3 Vertebroplasty Compared With a Sham-procedure for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01537770 Phase 4
4 Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting Completed NCT01847898 Phase 4
5 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
6 Comparison of Balloon Kyphoplasty and Vertebroplasty in Subacute Osteoporotic Vertebral Fractures Completed NCT00749086 Phase 4
7 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Completed NCT01383616 Phase 4
8 Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace Completed NCT02049931 Phase 4
9 VERtebral Fracture Treatment Comparisons in Osteoporotic Women Completed NCT01709110 Phase 4 Teriparatide;Risedronate;Placebo;Calcium;Vitamin D
10 Antiepileptic Drugs and Osteoporotic Prevention Trial Completed NCT00869622 Phase 4 Risedronate;Placebo + Calcium and Vitamin D
11 Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid Completed NCT00679978 Phase 4
12 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
13 Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) Recruiting NCT02589600 Phase 4 Zoledronic acid
14 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Recruiting NCT02148848 Phase 4 Risedronate
15 Preventing Osteoporosis Using Denosumab Recruiting NCT02753283 Phase 4 denosumab;Placebo
16 Study About the Effect of Preventive Adjacent Level Cement Augmentation After Osteoporotic Vertebral Compression Fractures Recruiting NCT02489825 Phase 4
17 Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures Recruiting NCT02908516 Phase 4 Tranexamic Acid;Placebo
18 Generic Zoledronic Acid Versus Original Zoledronic Acid in Postmenopausal Osteoporotic Women Not yet recruiting NCT03158246 Phase 4 Generic Zoledronic Acid;Original Zoledronic Acid
19 The PRIORi-T Trial--Prospective Randomized Investigation of Radiofrequency Targeted Vertebral Augmentation Withdrawn NCT01480167 Phase 4
20 Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer Unknown status NCT00957606 Phase 3
21 Early Rehabilitation After Hip Fracture Unknown status NCT00133640 Phase 3 cholecalciferol
22 Safety and Efficacy Study of Percutaneous Vertebroplasty for Painful Acute Osteoporotic Spine Fractures Unknown status NCT01677806 Phase 3
23 Secondary Prevention of Osteoporotic Fractures in Residents of Long-Term Care Facilities Completed NCT00280943 Phase 2, Phase 3
24 BONDIR Study: A Study of Intravenous Bonviva (Ibandronate) After Recent Vertebral Osteoporotic Fracture in Patients With Osteoporosis. Completed NCT00493623 Phase 3 Placebo;ibandronate [Bonviva/Boniva]
25 Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture Completed NCT00046254 Phase 3 Zoledronic Acid
26 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis Completed NCT00068822 Phase 3
27 Secondary Prevention of Osteoporosis Completed NCT00421343 Phase 3 alendronate with cholecalciferol;calcium carbonate with cholecalciferol
28 Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing Completed NCT01293721 Phase 2, Phase 3
29 Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer Completed NCT00859703 Phase 3 Risedronate;Placebo
30 Low-magnitude High-frequency Vibration Study on Fracture Rate in Community Elderly Completed NCT00973167 Phase 2, Phase 3
31 BREAST CANCER AND EXERCISE Completed NCT00639210 Phase 3
32 The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis Completed NCT00252421 Phase 3 Nitroglycerin ointment 15 mg/day daily for 24 month;Placebo ointment daily for 24 month
33 Calcium and Vitamin D Malnutrition in Elderly Women Completed NCT00352170 Phase 3
34 Comparison of Raloxifene Hydrochloride and Placebo in the Treatment of Postmenopausal Women With Osteoporosis Completed NCT00670319 Phase 3 Raloxifene HCL;Raloxifene HCL;Placebo
35 Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis Completed NCT00680953 Phase 3 Denosumab;Placebo;Alendronate sodium hydrate
36 Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy Completed NCT00053898 Phase 3 anastrozole;tamoxifen citrate
37 Bone Mineral Density in Postmenopausal Women With Primary Breast Cancer Who Are Receiving Treatment on Clinical Trial CAN-NCIC-MA27 Completed NCT00354302 Phase 3 alendronate sodium;calcium gluconate;risedronate sodium
38 A Trial of Vertebroplasty for Painful Acute Osteoporotic Vertebral Fractures Completed NCT01200277 Phase 3
39 Cost Effectiveness and Efficacy of Kyphoplasty and Vertebroplasty Trial Completed NCT00279877 Phase 3
40 A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018) Completed NCT00529373 Phase 3 Odanacatib;Placebo for Odanacatib
41 Trial to Evaluate Tibolone in the Treatment of Osteoporosis (P06468) Completed NCT00519857 Phase 3 Tibolone;Placebo
42 Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis Completed NCT00343252 Phase 3 teriparatide;risedronate;placebo;placebo
43 The Kiva® System as a Vertebral Augmentation Treatment Completed NCT01123512 Phase 3
44 Teriparatide Use in Hip Replaced Subjects Completed NCT00191321 Phase 3 Teriparatide
45 A New Active Vitamin D, ED-71 for Osteoporosis Completed NCT00144456 Phase 3 ED-71;Alfacalcidol;ED-71 placebo;Alfacalcidol placebo
46 Study Evaluating Bazedoxifene Acetate In Osteoporosis In Postmenopausal Women Completed NCT00205777 Phase 3 Bazedoxifene Acetate
47 Efficacy of Ferric Carboxymaltose With or Without EPO Reducing Red-cell Transfusion Packs in Hip Fracture Perioperative Period Completed NCT01154491 Phase 3 Ferric carboxymaltose;Erythropoietin;Placebo
48 Dynamic Magnetic Resonance (MR) Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research Completed NCT00172224 Phase 3
49 Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures Recruiting NCT01896011 Phase 3
50 Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Active, not recruiting NCT00697463 Phase 2, Phase 3 Teriparatide (PTH 1-34)

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

Anatomical Context for Osteoporotic Fracture

MalaCards organs/tissues related to Osteoporotic Fracture:

39
Bone, Bone Marrow, Prostate, Liver, Heart, Lung, Neutrophil

Publications for Osteoporotic Fracture

Articles related to Osteoporotic Fracture:

(show top 50) (show all 394)
id Title Authors Year
1
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease. ( 28530467 )
2017
2
An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8). ( 28711604 )
2017
3
Meta-analysis of hypertension and osteoporotic fracture risk in women and men. ( 28447105 )
2017
4
Increased detection of genetic loci associated with risk predictors of osteoporotic fracture using a pleiotropic cFDR method. ( 28373146 )
2017
5
FRAX-based Estimates of 10-year Probability of Hip and Major Osteoporotic Fracture Among Adults Aged 40 and Over: United States, 2013 and 2014. ( 28459415 )
2017
6
Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. ( 28587685 )
2017
7
Adherence to osteoporosis pharmacotherapy one year after osteoporotic fracture - a Swiss trauma center secondary prevention project. ( 28695555 )
2017
8
The Role of Exercises in Osteoporotic Fracture Prevention and Current Care Gaps. Where Are We Now? Recent Updates. ( 28786812 )
2017
9
Added clinical use of trabecular bone score to BMD for major osteoporotic fracture prediction in older Chinese people: the Mr. OS and Ms. OS cohort study in Hong Kong. ( 27725999 )
2017
10
Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: a population-based study in a tuberculosis-endemic area. ( 28331966 )
2017
11
The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exercise to reduce risk of osteoporotic fracture in older men with low bone mass. ( 28611110 )
2017
12
Getting Osteoporotic Fracture Risk Into Vascular Structure and Functiona88- Do You Know Your FRAX(Ar) Score? ( 28331114 )
2017
13
Evaluating osteoporotic fracture risk with the Fracture Risk Assessment Tool in Chinese patients with rheumatoid arthritis. ( 28471962 )
2017
14
A Model for Assessing the Clinical and Economic Benefits of Bone-forming Agents for Reducing Fractures in Postmenopausal Women at High, Near-term Risk of Osteoporotic Fracture. ( 28629610 )
2017
15
The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis. ( 28326300 )
2017
16
Prevalence and incidence of osteoporotic fractures in patients on long-term glucocorticoid treatment for rheumatic diseases: the Glucocorticoid Induced OsTeoporosis TOol (GIOTTO) study. ( 28535619 )
2017
17
Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011. ( 28642857 )
2017
18
Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. ( 28451733 )
2017
19
High incidence of vertebral osteoporotic fracture within the first year after liver transplantation. ( 28516878 )
2017
20
Relationship between vitamin D, osteoporotic fracture and falls. ( 28625513 )
2017
21
Efficacy of Kirschner-wires and tension band in hip arthroplasty for aged patients with unstable intertrochanteric osteoporotic fracture: A 2-to-11-year follow-up. ( 28072698 )
2017
22
Validity of major osteoporotic fracture diagnosis codes in the Clinical Data Analysis and Reporting System in Hong Kong. ( 28371079 )
2017
23
Organic Gallium Treatment Improves Osteoporotic Fracture Healing Through Affecting the OPG/RANKL Ratio and Expression of Serum Inflammatory Cytokines in Ovariectomized Rats. ( 28836172 )
2017
24
Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients: A Population-based Longitudinal Cohort Study. ( 27958221 )
2016
25
Correlation between osteoporotic fracture risk in Brazilian postmenopausal women calculated using the FRAX with and without the inclusion of bone densitometry data. ( 27067597 )
2016
26
Association of circulating dipeptidyl-peptidase 4 levels with osteoporotic fracture in postmenopausal women. ( 27866216 )
2016
27
Calcium status may modify the association of magnesium and potassium intake with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort study. ( 26728693 )
2016
28
Risk and clinical predictors of osteoporotic fracture in East Asian patients with chronic obstructive pulmonary disease: a population-based cohort study. ( 27812429 )
2016
29
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. ( 26733130 )
2016
30
The osteoporotic fracture prevention program in rural areas (OFRA): a protocol for a cluster-randomized health care fund driven intervention in a routine health care setting. ( 27821102 )
2016
31
Implementation of Models of Care for secondary osteoporotic fracture prevention and orthogeriatric Models of Care for osteoporotic hip fracture. ( 27886945 )
2016
32
The use of augmentation techniques in osteoporotic fracture fixation. ( 27338226 )
2016
33
Use of teriparatide in osteoporotic fracture patients. ( 26768289 )
2016
34
Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk. ( 27465306 )
2016
35
Finger Fractures as an Early Manifestation of Primary Hyperparathyroidism Among Young Patients: A Case Report of a 30-Year-Old Male With Recurrent Osteoporotic Fractures. ( 27196476 )
2016
36
A Study on the Correlation of Pertrochanteric Osteoporotic Fracture Severity with the Severity of Osteoporosis. ( 27190907 )
2016
37
Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study. ( 26981519 )
2016
38
Low-magnitude high-frequency vibration enhanced mesenchymal stem cell recruitment in osteoporotic fracture healing through the SDF-1/CXCR4 pathway. ( 27215741 )
2016
39
Prediction of Future Osteoporotic Fracture Occurrence by Genetic Profiling: A 6-Year Follow-Up Observational Study. ( 26756118 )
2016
40
Development of a Korean Fracture Risk Score (KFRS) for Predicting Osteoporotic Fracture Risk: Analysis of Data from the Korean National Health Insurance Service. ( 27399597 )
2016
41
DUAL-ENERGY X-RAY ABSORPTIOMETRY AND CALCULATED FRAX RISK SCORES MAY UNDERESTIMATE OSTEOPOROTIC FRACTURE RISK IN VITAMIN D-DEFICIENT VETERANS WITH HIV INFECTION. ( 26684149 )
2016
42
Predicting the 10-year risk of hip and major osteoporotic fracture in rheumatoid arthritis and in the general population: an independent validation and update of UK FRAX without bone mineral density. ( 26984006 )
2016
43
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model. ( 26723576 )
2016
44
BMP7 gene polymorphisms are not associated with bone mineral density or osteoporotic fractures in postmenopausal Chinese women. ( 27264311 )
2016
45
Objectively-Verified Parental Non-Hip Major Osteoporotic Fractures and Offspring Osteoporotic Fracture Risk: A Population-Based Familial Linkage Study. ( 27859612 )
2016
46
Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review. ( 27055104 )
2016
47
Main differences in osteoporotic fracture models: which should I use? ( 26768283 )
2016
48
Effects of Roughly Focused Extracorporeal Shock Waves Therapy on the Expressions of Bone Morphogenetic Protein-2 and Osteoprotegerin in Osteoporotic Fracture in Rats. ( 27779163 )
2016
49
How Good is Our Best Guess? Clinical Application of the WHO FRAX Tool in Osteoporotic Fracture Risk Determination and Treatment Decisions. ( 27038319 )
2016
50
Perceived stress and risk of any osteoporotic fracture. ( 26786258 )
2016

Variations for Osteoporotic Fracture

Expression for Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for Osteoporotic Fracture

GO Terms for Osteoporotic Fracture

Sources for Osteoporotic Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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