MCID: OST097
MIFTS: 34

Osteoporotic Fracture malady

Bone diseases category

Aliases & Classifications for Osteoporotic Fracture

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Sources:
43Novoseek, 60UMLS
See all sources

Osteoporotic Fracture, Aliases & Descriptions:

Name: Osteoporotic Fracture 43
 
Osteoporotic Fractures 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Summaries for Osteoporotic Fracture

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MalaCards based summary: Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteonecrosis and osteoarthritis. An important gene associated with Osteoporotic Fracture is CER1 (cerberus 1, DAN family BMP antagonist), and among its related pathways are TGF-beta Signaling Pathway and Wnt Signaling Pathway. The compounds calcium carbonate and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are growth/size/body and limbs/digits/tail.

Related Diseases for Osteoporotic Fracture

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Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis30.6BGLAP
2osteoarthritis30.3COL1A1, IBSP, BGLAP
3osteoporosis30.2BGLAP, IBSP, PTH, SOST, COL1A1
4periodontal disease30.0IBSP, BGLAP
5breast cancer10.4
6atrial fibrillation10.3
7cervicitis10.3
8postural hypotension10.3
9hyperostosis, endosteal10.2PTH, SOST
10rheumatoid arthritis10.1
11hyperprolactinemia10.1
12insulin-like growth factor i10.1
13obesity10.1
14anorexia nervosa10.1
15arthritis10.1
16liver disease10.1
17spinal cord injury10.1
18spinal stenosis10.1
19fatty liver disease10.1
20cervical dystonia10.1
21prolactinoma10.1
22irritable bowel syndrome10.1
23empty sella syndrome10.1
24cerebrovascular disease10.1
25dystonia10.1
26periodontitis10.1
27back pain10.1
28osteonecrosis of the jaw10.1
29dentinogenesis imperfecta10.1IBSP, COL1A1
30osteogenesis imperfecta, type i10.0BGLAP, COL1A1
31pseudohypoparathyroidism, type ib10.0BGLAP, PTH
32idiopathic juvenile osteoporosis10.0COL1A1, BGLAP
33osteitis fibrosa10.0PTH, BGLAP
34pseudohypoparathyroidism10.0PTH, BGLAP
35renal osteodystrophy10.0PTH, BGLAP
36hypophosphatemia10.0PTH, BGLAP
37hypoparathyroidism10.0PTH, BGLAP
38secondary hyperparathyroidism of renal origin10.0BGLAP, PTH
39osteomalacia10.0BGLAP, PTH
40rickets10.0PTH, BGLAP
41fibrous dysplasia10.0IBSP, BGLAP
42spondyloarthropathy 110.0PTH, BGLAP
43goiter9.9BGLAP, PTH
44hyperparathyroidism9.9PTH, BGLAP
45bone cancer9.9BGLAP, IBSP
46metabolic acidosis9.9PTH, BGLAP
47hypercalcemia9.9PTH, BGLAP
48hyperostosis9.8COL1A1, SOST, BGLAP
49hyperthyroidism9.8PTH, BGLAP
50primary hyperparathyroidism9.8BGLAP, IBSP, PTH

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to osteoporotic fracture

Symptoms for Osteoporotic Fracture

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Drugs & Therapeutics for Osteoporotic Fracture

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Drug clinical trials:

Search ClinicalTrials for Osteoporotic Fracture

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

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Anatomical Context for Osteoporotic Fracture

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MalaCards organs/tissues related to Osteoporotic Fracture:

31
Bone, Breast, Testes, Spinal cord, Heart, Liver

Animal Models for Osteoporotic Fracture or affiliated genes

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MGI Mouse Phenotypes related to Osteoporotic Fracture:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0COL1A1, CER1, SOST, PTH, IBSP
2MP:00053717.7IBSP, PTH, SOST, CER1, COL1A1
3MP:00053907.5COL1A1, WNT16, CER1, SOST, PTH, IBSP

Publications for Osteoporotic Fracture

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Articles related to Osteoporotic Fracture:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Effect of B vitamin (folate, b6, and B12) supplementation on osteoporotic fracture and bone turnover markers: a meta-analysis. (25805360)
2015
2
Bone three-dimensional microstructural features of the common osteoporotic fracture sites. (25232524)
2014
3
Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture. (24764277)
2014
4
Evaluation of the prescription of osteoporosis treatment after a major osteoporotic fracture. (25160027)
2014
5
Incidence and risk of venous thromboembolism among Taiwan osteoporotic fracture population under osteoporosis pharmacological treatments. (24606074)
2014
6
Post-fracture pharmacotherapy for women with osteoporotic fracture: analysis of a managed care population in the USA. (25112720)
2014
7
The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX. (24980183)
2014
8
Performance of risk assessment instruments for predicting osteoporotic fracture risk: a systematic review. (24105431)
2014
9
Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data. (24345885)
2013
10
A glimpse from the past: osteoporosis and osteoporotic fractures in a portuguese identified skeletal sample. (24131908)
2013
11
High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women. (23023015)
2013
12
What was your fracture risk evaluated by FRAXAr the day before your osteoporotic fracture? (23114631)
2013
13
Standard radiography: untapped potential in the assessment of osteoporotic fracture risk. (23187729)
2013
14
Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. (24065012)
2013
15
Role of medicinal plants and natural products on osteoporotic fracture healing. (22973405)
2012
16
Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. (22619194)
2012
17
Clinical characteristics, bone mineral density and non-vertebral osteoporotic fracture outcomes among post-menopausal U.S. South Asian Women. (22921875)
2012
18
FRAXAr probabilities and risk of major osteoporotic fracture in France. (22179418)
2012
19
Association between nonalcoholic fatty liver disease (NAFLD) and osteoporotic fracture in middle-aged and elderly Chinese. (22466338)
2012
20
Three-year experience with combined treatment with alendronate and alfacalcidol in Japanese patients with severe bone loss and osteoporotic fracture. (21753888)
2011
21
Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. (20094707)
2010
22
Comparison of a new minimum contact locking plate and the limited contact dynamic compression plate in an osteoporotic fracture model. (19089425)
2009
23
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. (19841454)
2009
24
Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. (18974918)
2009
25
Osteoporotic fracture risk in elderly women: estimation with quantitative heel US and clinical risk factors. (18483227)
2008
26
Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS). (17499570)
2007
27
Measures of renal function, BMD, bone loss, and osteoporotic fracture in older adults: the Rancho Bernardo study. (17059370)
2007
28
The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. (17555504)
2007
29
Digital x-ray radiogrammetry identifies women at risk of osteoporotic fracture: results from a prospective study. (16868669)
2006
30
Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. (16391245)
2006
31
Osteoporotic fractures and vitamin D deficiency. (16820826)
2006
32
Review: developmental origins of osteoporotic fracture. (16331359)
2006
33
Bone tissue compositional differences in women with and without osteoporotic fracture. (16901772)
2006
34
Low femoral bone mineral density and quantitative ultrasound are risk factors for new osteoporotic fracture and total and cardiovascular mortality: a 5-year population-based study of Brazilian elderly women. (16510866)
2006
35
Severity of obstructive airway disease and risk of osteoporotic fracture. (15863646)
2005
36
Thoracic osteoporotic fracture without upper back pain. (15314538)
2004
37
Fracture risk following an osteoporotic fracture. (14691617)
2004
38
Percutaneous vertebroplasty for osteoporotic fracture: preliminary experience at Middlemore Hospital. (15477925)
2004
39
Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. (12810179)
2003
40
The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population. (12730754)
2003
41
Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies. (11792594)
2002
42
Does high intake of vitamin A pose a risk for osteoporotic fracture? (11903019)
2002
43
Reconsidering the effects of antiresorptive therapies in reducing osteoporotic fracture. (11760829)
2001
44
Exercise for prevention of osteoporotic fracture. (11769785)
2001
45
Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. (10752709)
2000
46
Hormonal and biochemical parameters and osteoporotic fractures in elderly men. (10893691)
2000
47
Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group. (9661081)
1998
48
Water fluoridation and osteoporotic fracture. (8897754)
1996
49
Calcium intake in the osteoporotic fracture context: introduction. (2053569)
1991
50
Prolactinoma in a middle-aged man with an osteoporotic fracture. (2763547)
1989

Variations for Osteoporotic Fracture

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Expression for genes affiliated with Osteoporotic Fracture

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Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for genes affiliated with Osteoporotic Fracture

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Pathways related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CER1, SOST
2
Show member pathways
Wnt Signaling Pathway NetPath36
9.2WNT16, CER1, SOST
3
Show member pathways
9.2SOST, CER1, WNT16
49.0IBSP, BGLAP
58.8IBSP, PTH, COL1A1
68.6COL1A1, PTH, BGLAP
78.0COL1A1, PTH, IBSP, BGLAP

Compounds for genes affiliated with Osteoporotic Fracture

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Compounds related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

(show all 31)
idCompoundScoreTop Affiliating Genes
1calcium carbonate439.5PTH, BGLAP
2pamidronate43 49 1211.5PTH, BGLAP
3alendronate43 49 1211.4PTH, BGLAP
4glycosaminoglycan439.4IBSP, COL1A1
5ibandronate43 1210.4BGLAP, IBSP
6alizarin439.4IBSP, BGLAP
725-hydroxyvitamin d439.4PTH, BGLAP
8phosphorus439.4BGLAP, PTH
9chitosan439.3IBSP, BGLAP
10titanium439.3BGLAP, IBSP
11zoledronic acid439.3IBSP, BGLAP
12estrone43 28 24 1212.2PTH, BGLAP
13ibmx43 59 2811.2IBSP, PTH
14hydroxyapatite439.2IBSP, BGLAP
15thyroxine43 2410.1PTH, BGLAP
16thymidine43 2410.0COL1A1, PTH, IBSP
17deoxypyridinoline438.9PTH, IBSP, BGLAP
18simvastatin43 49 59 28 24 1213.8COL1A1, BGLAP
19estradiol43 24 1210.8BGLAP, IBSP, PTH
20creatinine438.7BGLAP, IBSP, PTH
21arginine438.6COL1A1, PTH, BGLAP
22hydroxyproline43 24 1210.4COL1A1, PTH, IBSP, BGLAP
23procollagen438.4BGLAP, IBSP, PTH, COL1A1
241,25 dihydroxy vitamin d3438.4BGLAP, IBSP, PTH, COL1A1
25pge2438.3COL1A1, PTH, IBSP, BGLAP
26dexamethasone43 49 28 1211.3BGLAP, IBSP, PTH, COL1A1
27vegf438.3BGLAP, IBSP, PTH, COL1A1
28cysteine438.0BGLAP, IBSP, SOST, CER1, COL1A1
29vitamin d437.9BGLAP, IBSP, PTH, SOST, COL1A1
30estrogen437.9BGLAP, IBSP, PTH, SOST, COL1A1
31calcium43 49 24 1210.8BGLAP, IBSP, PTH, SOST, COL1A1

GO Terms for genes affiliated with Osteoporotic Fracture

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Cellular components related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2IBSP, PTH, CER1, WNT16, COL1A1, BGLAP
2extracellular spaceGO:00056157.1COL1A1, WNT16, CER1, SOST, PTH, BGLAP

Biological processes related to Osteoporotic Fracture according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of BMP signaling pathwayGO:00305149.8CER1, SOST
2Wnt signaling pathwayGO:00160559.6WNT16, SOST
3bone mineralizationGO:00302829.5BGLAP, CER1
4response to vitamin DGO:00332809.3PTH, BGLAP
5ossificationGO:00015039.3IBSP, SOST
6response to mechanical stimulusGO:00096129.3SOST, BGLAP
7cellular response to growth factor stimulusGO:00713639.1BGLAP, IBSP
8osteoblast differentiationGO:00016499.1COL1A1, BGLAP
9skeletal system developmentGO:00015018.8COL1A1, PTH, BGLAP
10response to ethanolGO:00454718.8PTH, BGLAP

Products for genes affiliated with Osteoporotic Fracture

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  • Antibodies
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  • Kits and Assays

Sources for Osteoporotic Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet