MCID: OST097
MIFTS: 47

Osteoporotic Fracture malady

Bone diseases category

Summaries for Osteoporotic Fracture

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32MalaCards
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MalaCards: Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteoarthritis. An important gene associated with Osteoporotic Fracture is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Osteoclast Signaling and Crosslinking of collagen fibrils. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Osteoporotic Fracture

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30LifeMap Discovery™, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoporotic fracture 30 44
osteoporotic fractures 60


Related Diseases for Osteoporotic Fracture

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17GeneCards, 18GeneDecks
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Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.9SP1, PTH, SLPI, COL1A2, COL1A1, BGLAP
2osteoarthritis30.6COL1A2, COL1A1, BGLAP, IBSP, CALCA, TNFSF11
3breast cancer30.5IBSP, CALCA, CALCR, TNFSF11, TNFRSF11B, FLT3
4osteonecrosis30.1BGLAP
5hyperprolactinemia30.1SHBG
6anorexia nervosa30.1SHBG, TNFRSF11B
7diabetes mellitus30.1BGLAP, CALCA, SHBG, PTH
8rheumatoid arthritis30.1BGLAP, IBSP, TNFSF11, TNFRSF11B, IL1RN
9arthritis30.1SP1, IL1RN, PHB2, TNFRSF11B, TNFSF11, CALCA
10bone fracture10.9
11cervicitis10.3
12parkinson's disease10.1
13prolactinoma10.1
14empty sella syndrome10.1
15fatty liver disease10.1
16spinal stenosis10.1
17irritable bowel syndrome10.1
18adult syndrome10.1
19cerebrovascular disease10.1
20liver disease10.1
21type 2 diabetes mellitus10.1
22periodontal disease10.0TNFSF11
23root resorption10.0TNFRSF11B
24nephrolithiasis10.0PTH
25thyroiditis10.0CALCA
26psoriatic arthritis10.0PHB2
27peritonitis10.0SLPI
28dermatomyositis10.0IL1RN
29inflammatory bowel disease10.0IL1RN
30obesity10.0SHBG
31psoriasis10.0SLPI
32amenorrhea10.0SHBG
33dentin dysplasia10.0IBSP
34liver cirrhosis10.0SLPI
35severe combined immunodeficiency10.0FLT3
36growth hormone deficiency10.0BGLAP
37multiple myeloma10.0TNFSF11, TNFRSF11B
38polycystic ovary syndrome10.0SHBG
39glomerulonephritis10.0IL1RN
40gingivitis10.0TNFSF11, TNFRSF11B
41hyperostosis10.0BGLAP, COL1A1
42acne10.0SHBG
43acute myocardial infarction10.0TNFSF11
44osteomyelitis10.0TNFSF11, IBSP
45acromegaly10.0SHBG, BGLAP
46hypothyroidism10.0SHBG, PTH
47osteitis fibrosa10.0PTH, BGLAP
48myocardial infarction10.0SP1, SHBG
49neutropenia10.0IL1RN
50osteogenesis imperfecta type i10.0COL1A2, COL1A1

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to osteoporotic fracture

Clinical Features for Osteoporotic Fracture

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Drugs & Therapeutics for Osteoporotic Fracture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Osteoporotic Fracture

Drug clinical trials:

Search ClinicalTrials for Osteoporotic Fracture

Search NIH Clinical Center for Osteoporotic Fracture

Search CenterWatch for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

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Anatomical Context for Osteoporotic Fracture

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32MalaCards
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MalaCards organs/tissues related to Osteoporotic Fracture:

32
Bone, Breast, Testes, Spinal cord, Heart, Liver, Skin

Animal Models for Osteoporotic Fracture or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteoporotic Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.4COL1A2, CER1
2MP:000539010.0CER1, WNT16, TNFRSF11B, TNFSF11, CALCR, IBSP
3MP:00053829.9CER1, SP1, PTH, TNFRSF11B, TNFSF11, COL1A1
4MP:00053859.6COL1A2, COL1A1, CALCA, TNFRSF11B, IL1RN, PTH
5MP:00053979.5COL1A1, CALCR, TNFSF11, TNFRSF11B, FLT3, IL1RN
6MP:00107719.4COL1A2, COL1A1, CALCA, TNFSF11, PHB2, IL1RN
7MP:00053789.4COL1A2, COL1A1, IBSP, TNFSF11, TNFRSF11B, PHB2
8MP:00107689.2COL1A2, COL1A1, CALCA, CALCR, TNFSF11, TNFRSF11B

Publications for Osteoporotic Fracture

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50PubMed
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Articles related to Osteoporotic Fracture:

(show top 50)    (show all 315)
idTitleAuthorsYear
1
Lumbar disc degeneration in osteoporotic men: prevalence and assessment of the relation with presence of vertebral fracture. (23729808)
2013
2
Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. (24065012)
2013
3
Compound risk of high mortality following osteoporotic fracture and refracture in elderly women and men. (23616397)
2013
4
Low-modulus Mg/PCL hybrid bone substitute for osteoporotic fracture fixation. (23787111)
2013
5
Osteoporotic fractures and persistent non-fusion of the hand epiphyses caused by empty sella syndrome in an adult: a case report. (24029021)
2013
6
Role of medicinal plants and natural products on osteoporotic fracture healing. (22973405)
2012
7
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. (22407876)
2012
8
Bilateral pedicle stress fracture with adjacent old osteoporotic compression fractures that induced spondylolisthesis. (23073655)
2012
9
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. (22792071)
2012
10
Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women. (21187701)
2011
11
Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. (20094707)
2010
12
FRAX assessment of osteoporotic fracture probability in Switzerland. (19517155)
2010
13
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. (20096396)
2010
14
Quantitation of individual risk for osteoporotic fracture. (20718256)
2010
15
Developmental origins of osteoporotic fracture. (19227545)
2009
16
Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. (20146870)
2009
17
Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. (19016585)
2009
18
The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. (19619110)
2009
19
Association between alcohol consumption and both osteoporotic fracture and bone density. (18456037)
2008
20
Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspective. (19028356)
2008
21
Evaluation of POSSUM scoring system in the treatment of osteoporotic fracture of the hip in elder patients. (18377711)
2008
22
Loop diuretic use and increased rates of hip bone loss in older men: the Osteoporotic Fractures in Men Study. (18413556)
2008
23
Treatment of combined osteoporotic compression fractures and spinal stenosis: use of vertebral augumentation and interspinous process spacer. (18758354)
2008
24
The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. (17555504)
2007
25
Association of FLT3 polymorphisms with low BMD and risk of osteoporotic fracture in postmenopausal women. (17620055)
2007
26
Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. (16391245)
2006
27
Low femoral bone mineral density and quantitative ultrasound are risk factors for new osteoporotic fracture and total and cardiovascular mortality: a 5-year population-based study of Brazilian elderly women. (16510866)
2006
28
T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures. (16777502)
2006
29
Mandibular osteoporotic fracture: A case report. (17198516)
2006
30
beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures. (15765180)
2005
31
Fracture risk following an osteoporotic fracture. (14691617)
2004
32
Percutaneous vertebroplasty for osteoporotic fracture: preliminary experience at Middlemore Hospital. (15477925)
2004
33
Cost-effectiveness of quantitative ultrasound as a technique for screening of osteoporotic fracture risk: report on a health technology assessment conducted in 2001. (19675686)
2004
34
Nulliparity and osteoporotic fracture risk. (14969405)
2004
35
Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. (12810179)
2003
36
Discriminatory ability of quantitative ultrasound measurements is similar to dual-energy X-ray absorptiometry in a Brazilian women population with osteoporotic fracture. (14517710)
2003
37
Allele frequency of the G-->T mutation of the col1A1 gene analyzed by an ARMS-PCR in osteoporotic subjects with femoral neck fractures. (12211646)
2002
38
Effects of hyperprolactinemia on osteoporotic fracture risk in premenopausal women. (11293923)
2001
39
Immune phenotype and intracellular cytokine production of peripheral blood mononuclear cells from postmenopausal patients with osteoporotic fractures. (11672994)
2001
40
Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures. (11595622)
2001
41
Bone mineral density and bone loss measured at the radius to predict the risk of nonspinal osteoporotic fracture. (11393790)
2001
42
Effect of vitamin K and/or D on undercarboxylated and intact osteocalcin in osteoporotic patients with vertebral or hip fractures. (11207637)
2001
43
A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. PROOF Study Group. (10996576)
2000
44
A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. (10624458)
1999
45
Osteoporotic fracture among older U.S. women: risk factors quantified. (10342937)
1998
46
Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. (9258758)
1997
47
Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor I: potential implications for age-related (type II) osteoporotic fracture occurrence. (9262505)
1997
48
Estrogens, bone mass, and osteoporotic fracture. (1750409)
1991
49
Relative risk factors for osteoporotic fracture: a pilot study of the MEDOS questionnaire. (2065507)
1991
50
Treatment of osteoporotic fracture. (6140350)
1984

Genetic Variations for Osteoporotic Fracture

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Expression for genes affiliated with Osteoporotic Fracture

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for genes affiliated with Osteoporotic Fracture

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Osteoporotic Fracture

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1pge24410.8COL1A1
2estrogen4410.8PHB2
3procollagen4410.7COL1A2, TNFSF11
4cycloheximide4410.5UGT2B17, PTH, IBSP
5raloxifene44 28 49 1113.4SLPI, TNFSF11, CALCA, TNFRSF11B
6clodronate44 49 1112.4TNFRSF11B, TNFSF11, CALCA, SLPI
7ipriflavone4410.4SLPI, BGLAP, CALCA
8teriparatide44 1111.4BGLAP, CALCA, TNFRSF11B, TNFSF11
9ibandronate44 1111.4TNFRSF11B, TNFSF11, CALCA, IBSP, BGLAP
10etidronate4410.3BGLAP, CALCA, TNFRSF11B, SLPI
11denosumab44 1111.3TNFSF11, CALCA, TNFRSF11B
12pamidronate44 49 1112.3TNFSF11, CALCA, BGLAP, PTH, TNFRSF11B
13vitamin k24410.3TNFRSF11B, TNFSF11, BGLAP, CALCA, SLPI
14deoxypyridinoline4410.3PTH, TNFRSF11B, TNFSF11, IBSP, BGLAP, CALCA
15strontium ranelate4410.3TNFSF11, CALCA, IBSP
16risedronate44 59 49 28 1114.3TNFSF11, CALCA, BGLAP, TNFRSF11B, SLPI
17pyridinoline4410.3TNFRSF11B, SLPI, CALCA, IBSP, BGLAP
18titanium4410.3IBSP, TNFSF11, TNFRSF11B, SLPI, BGLAP
19tartrate4410.3BGLAP, CALCR, TNFSF11, SLPI, CALCA
20zoledronic acid4410.2TNFRSF11B, SLPI, TNFSF11, CALCA, IBSP, BGLAP
21hydroxyapatite4410.2BGLAP, SLPI, TNFRSF11B, TNFSF11, IBSP
22alendronate44 49 1112.2PTH, SLPI, TNFRSF11B, TNFSF11, BGLAP, CALCA
23phosphorus4410.2BGLAP, CALCA, PTH, SLPI, TNFRSF11B, TNFSF11
24forskolin44 49 1112.2SP1, CALCA, IBSP, CALCR, PTH
25hydroxyproline44 11 2412.1TNFRSF11B, COL1A1, BGLAP, IBSP, CALCA, SLPI
26simvastatin44 49 59 28 11 2415.1COL1A2, BGLAP, SHBG, IL1RN, SP1, COL1A1
2725-hydroxyvitamin d4410.1SHBG, TNFRSF11B, CALCA, PTH, BGLAP, TNFSF11
28estradiol44 11 2412.1SHBG, PHB2, SLPI, IBSP, SP1, CALCR
29hydrocortisone44 2 59 1113.1TNFRSF11B, CALCA, LCT, SHBG, IL1RN, BGLAP
30estrone44 28 11 2413.1UGT2B17, SHBG, PTH, SP1, BGLAP
31ascorbic acid44 2411.1SLPI, IL1RN, SHBG, TNFRSF11B, TNFSF11, IBSP
32azathioprine44 49 2 1113.1BGLAP, TNFSF11, TNFRSF11B, SP1, SLPI
33tamoxifen44 49 28 1113.0PTH, SLPI, BGLAP, TNFRSF11B, UGT2B17, SHBG
34aspartate4410.0COL1A2, COL1A1, FLT3, SHBG
35cyclosporin a44 28 5911.9BGLAP, CALCA, SLPI, TNFSF11, TNFRSF11B, CALCR
361,25 dihydroxy vitamin d3449.9SP1, CALCR, CALCA, TNFSF11, IBSP, BGLAP
37creatinine449.9IBSP, TNFSF11, CALCR, BGLAP, SLPI, PTH
38cysteine449.9CER1, SP1, SLPI, TNFSF11, IBSP, LCT
39calcitriol44 59 11 2412.9SP1, PTH, SLPI, CALCR, CALCA, TNFSF11
40steroid449.8TNFSF11, SP1, SLPI, SHBG, UGT2B17, TNFRSF11B
41ns 39844 5910.8TNFRSF11B, BGLAP, IL1RN, TNFSF11
42thymidine44 2410.7SLPI, SP1, PTH, FLT3, IBSP, COL1A1
43testosterone44 59 11 2412.7BGLAP, SP1, PTH, SLPI, IL1RN, UGT2B17
44retinoic acid44 2410.7TNFRSF11B, UGT2B17, SLPI, IL1RN, BGLAP, COL1A1
45heparin44 28 11 2412.7TNFRSF11B, BGLAP, IBSP, LCT, TNFSF11, SLPI
46dexamethasone44 49 28 1112.7PTH, SLPI, SP1, IL1RN, SHBG, TNFRSF11B
47vegf449.7IL1RN, SLPI, PTH, IBSP, SP1, BGLAP
48phosphatidylinositol449.6SP1, CALCR, COL1A2, IBSP, TNFSF11, TNFRSF11B
49vitamin d449.5SHBG, TNFRSF11B, TNFSF11, CALCR, CALCA, IBSP
50calcium44 49 11 2412.4IBSP, COL1A1, PTH, SLPI, BGLAP, LCT

GO Terms for genes affiliated with Osteoporotic Fracture

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16Gene Ontology
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Cellular components related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IGO:00558410.3COL1A1, COL1A2
2extracellular spaceGO:0056159.2CALCA, BGLAP, COL1A1, COL1A2, TNFSF11, TNFRSF11B
3extracellular regionGO:0055769.1CER1, COL1A2, COL1A1, BGLAP, IBSP, CALCA

Biological processes related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1skin morphogenesisGO:04358910.4COL1A1, COL1A2
2positive regulation of adenylate cyclase activityGO:04576210.4CALCR, CALCA
3positive regulation of cAMP biosynthetic processGO:03081910.4PTH, CALCR, CALCA
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.4CALCA, CALCR, PTH
5negative regulation of bone resorptionGO:04577910.3CALCA, TNFRSF11B
6response to glucocorticoid stimulusGO:05138410.3BGLAP, CALCR, IL1RN
7protein heterotrimerizationGO:07020810.3COL1A1, COL1A2
8monocyte chemotaxisGO:00254810.3TNFSF11, CALCA
9ossificationGO:00150310.2SP1, TNFSF11, IBSP
10skeletal system developmentGO:00150110.2PTH, TNFRSF11B, BGLAP, COL1A1, COL1A2
11extracellular matrix organizationGO:03019810.0COL1A2, COL1A1, IBSP, TNFRSF11B
12mammary gland alveolus developmentGO:0607499.9PHB2, TNFSF11

Molecular functions related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.3COL1A1, COL1A2

Products for genes affiliated with Osteoporotic Fracture

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Osteoporotic Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet