MCID: OST097
MIFTS: 47

Osteoporotic Fracture malady

Bone diseases category

Summaries for Osteoporotic Fracture

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32MalaCards
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MalaCards: Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteoporosis and osteoarthritis. An important gene associated with Osteoporotic Fracture is IL1RN (interleukin 1 receptor antagonist), and among its related pathways are Osteoclast Signaling and Crosslinking of collagen fibrils. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Osteoporotic Fracture

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30LifeMap Discovery™, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

osteoporotic fracture 30 44
osteoporotic fractures 60


Related Diseases for Osteoporotic Fracture

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17GeneCards, 18GeneDecks
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Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.9SP1, PTH, SLPI, COL1A2, COL1A1, BGLAP
2osteoarthritis30.6COL1A2, COL1A1, BGLAP, IBSP, CALCA, TNFSF11
3breast cancer30.5IBSP, CALCA, CALCR, TNFSF11, TNFRSF11B, FLT3
4osteonecrosis30.1BGLAP
5hyperprolactinemia30.1SHBG
6anorexia nervosa30.1SHBG, TNFRSF11B
7diabetes mellitus30.1BGLAP, CALCA, SHBG, PTH
8rheumatoid arthritis30.1BGLAP, IBSP, TNFSF11, TNFRSF11B, IL1RN
9arthritis30.1SP1, IL1RN, PHB2, TNFRSF11B, TNFSF11, CALCA
10bone fracture10.9
11cervicitis10.3
12parkinson's disease10.1
13prolactinoma10.1
14empty sella syndrome10.1
15fatty liver disease10.1
16spinal stenosis10.1
17irritable bowel syndrome10.1
18adult syndrome10.1
19cerebrovascular disease10.1
20liver disease10.1
21type 2 diabetes mellitus10.1
22periodontal disease10.0TNFSF11
23root resorption10.0TNFRSF11B
24nephrolithiasis10.0PTH
25thyroiditis10.0CALCA
26psoriatic arthritis10.0PHB2
27peritonitis10.0SLPI
28dermatomyositis10.0IL1RN
29inflammatory bowel disease10.0IL1RN
30obesity10.0SHBG
31psoriasis10.0SLPI
32amenorrhea10.0SHBG
33dentin dysplasia10.0IBSP
34liver cirrhosis10.0SLPI
35severe combined immunodeficiency10.0FLT3
36growth hormone deficiency10.0BGLAP
37multiple myeloma10.0TNFSF11, TNFRSF11B
38polycystic ovary syndrome10.0SHBG
39glomerulonephritis10.0IL1RN
40gingivitis10.0TNFSF11, TNFRSF11B
41hyperostosis10.0BGLAP, COL1A1
42acne10.0SHBG
43acute myocardial infarction10.0TNFSF11
44osteomyelitis10.0TNFSF11, IBSP
45acromegaly10.0SHBG, BGLAP
46hypothyroidism10.0SHBG, PTH
47osteitis fibrosa10.0PTH, BGLAP
48myocardial infarction10.0SP1, SHBG
49neutropenia10.0IL1RN
50osteogenesis imperfecta type i10.0COL1A2, COL1A1

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to osteoporotic fracture

Clinical Features for Osteoporotic Fracture

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Drugs & Therapeutics for Osteoporotic Fracture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Osteoporotic Fracture

Drug clinical trials:

Search ClinicalTrials for Osteoporotic Fracture

Search NIH Clinical Center for Osteoporotic Fracture

Search CenterWatch for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

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Anatomical Context for Osteoporotic Fracture

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32MalaCards
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MalaCards organs/tissues related to Osteoporotic Fracture:

32
Bone, Breast, Testes, Spinal cord, Heart, Liver, Skin

Animal Models for Osteoporotic Fracture or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Osteoporotic Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.4COL1A2, CER1
2MP:000539010.0CER1, WNT16, TNFRSF11B, TNFSF11, CALCR, IBSP
3MP:00053829.9CER1, SP1, PTH, TNFRSF11B, TNFSF11, COL1A1
4MP:00053859.6COL1A2, COL1A1, CALCA, TNFRSF11B, IL1RN, PTH
5MP:00053979.5COL1A1, CALCR, TNFSF11, TNFRSF11B, FLT3, IL1RN
6MP:00107719.4COL1A2, COL1A1, CALCA, TNFSF11, PHB2, IL1RN
7MP:00053789.4COL1A2, COL1A1, IBSP, TNFSF11, TNFRSF11B, PHB2
8MP:00107689.2COL1A2, COL1A1, CALCA, CALCR, TNFSF11, TNFRSF11B

Publications for Osteoporotic Fracture

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50PubMed
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Articles related to Osteoporotic Fracture:

(show top 50)    (show all 315)
idTitleAuthorsYear
1
What was your fracture risk evaluated by FRAXAr the day before your osteoporotic fracture? (23114631)
2013
2
Update on statins: hope for osteoporotic fracture healing treatment. (23876090)
2013
3
"Osteoporotic fragility fractures: medical and surgical approaches" II National Congress of the Italian Orthopedic Group for the Study of Severe Osteoporosis (GISOOS). (24046039)
2013
4
Heterogeneity in Skeletal Load Adaptation Points to a Role for Modeling in the Pathogenesis of Osteoporotic Fracture. (23478079)
2013
5
Drug delivery systems for prevention and treatment of osteoporotic fracture. (24200294)
2013
6
Frax prediction without BMD for assessment of osteoporotic fracture risk. (24121261)
2013
7
Age as a predictor of osteoporotic fracture compared with current risk-prediction models. (24104773)
2013
8
Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. (22619194)
2012
9
Osteoporotic fracture treatment. (21954750)
2011
10
An Internet-based osteoporotic fracture risk program: effect on knowledge, attitudes, and behaviors. (21970565)
2011
11
Postural sway velocity predicts osteoporotic fracture in community-dwelling elderly Japanese women: the Muramatsu Study. (21071456)
2011
12
High serum total cholesterol is a long-term cause of osteoporotic fracture. (20821192)
2011
13
Polymorphisms and haplotypes across the osteoprotegerin gene associated with bone mineral density and osteoporotic fractures. (19436932)
2010
14
Hypovitaminosis D in Tunisian osteoporotic postmenopausal women and the relationship with bone fractures. (19537011)
2009
15
Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. (18974918)
2009
16
RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis. (19073256)
2009
17
Tamoxifen use and osteoporotic fracture risk: a population-based analysis. (18838712)
2008
18
Osteoporotic fracture management in India: a survey of orthopaedic surgeons. (18839642)
2008
19
Back pain in osteoporotic vertebral fractures. (18071648)
2008
20
Does supplementation with calcium alone or in combination with vitamin D reduce the risk of osteoporotic fracture? (18227815)
2008
21
Association of polymorphisms and haplotypes in the 5' region of COLIA1 gene with the risk of osteoporotic fractures in Russian women from Volga-Ural region]. (18619040)
2008
22
An approach for identifying postmenopausal women age 50-64 years at increased short-term risk for osteoporotic fracture. (17464525)
2007
23
MTHFR C677T polymorphism and osteoporotic fractures. (17712717)
2007
24
Spinal cord injury associated with thoracic osteoporotic fracture. (17314709)
2007
25
Relationship among bone mineral density, collagen composition, and biomechanical properties of callus in the healing of osteoporotic fracture. (18045519)
2007
26
Calcium and vitamin D for osteoporotic fracture prevention. (18320782)
2007
27
Osteoporotic fractures and vitamin D deficiency. (16820826)
2006
28
Bilateral L5 radiculopathy due to osteoporotic L1 vertebral fracture: A case report. (17044395)
2006
29
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. (15300362)
2005
30
Polymorphism of VDR gene--the most effective molecular marker of osteoporotic bone fractures risk within postmenopausal women from Wielkopolska region of Poland. (16350715)
2005
31
Does exercise during growth influence osteoporotic fracture risk later in life? (16340131)
2005
32
Homocysteine levels and the risk of osteoporotic fracture. (15141041)
2004
33
Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. (12534843)
2003
34
Is vitamin A consumption a risk factor for osteoporotic fracture? (15018484)
2003
35
Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk. (12810177)
2003
36
Spinal epidural lipomatosis with thoracic osteoporotic compression fracture causing paraplegia. (12923598)
2003
37
Osteoporotic fracture: missed opportunity for intervention. (12904835)
2003
38
The fetal origins of osteoporotic fracture. (11960204)
2002
39
The analgesic role of calcitonin following osteoporotic fracture. (12415432)
2002
40
Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. (10752709)
2000
41
Expert physician recommendations and current practice patterns for evaluating and treating men with osteoporotic hip fracture. (11037013)
2000
42
Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus. (10928224)
2000
43
Prevention of osteoporotic fractures in post-menopausal women. (11035905)
2000
44
Vitamin D receptor gene polymorphisms and the risk of fractures in older women. For the Study of Osteoporotic Fractures Research Group. (10491209)
1999
45
Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group. (9661081)
1998
46
Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. (9535665)
1998
47
Age-associated endocrine deficiencies as potential determinants of femoral neck (type II) osteoporotic fracture occurrence in elderly men. (9354182)
1997
48
Osteoporotic vertebral fractures in systemic mastocytosis without skin involvement]. (1330476)
1992
49
Calcium intake in the osteoporotic fracture context: introduction. (2053569)
1991
50
Internal fixation of the oblique, osteoporotic fracture of the lateral malleolus. (3229840)
1988

Genetic Variations for Osteoporotic Fracture

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Expression for genes affiliated with Osteoporotic Fracture

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for genes affiliated with Osteoporotic Fracture

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Osteoporotic Fracture

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1pge24410.8COL1A1
2estrogen4410.8PHB2
3procollagen4410.7COL1A2, TNFSF11
4cycloheximide4410.5UGT2B17, PTH, IBSP
5raloxifene44 28 49 1113.4SLPI, TNFSF11, CALCA, TNFRSF11B
6clodronate44 49 1112.4TNFRSF11B, TNFSF11, CALCA, SLPI
7ipriflavone4410.4SLPI, BGLAP, CALCA
8teriparatide44 1111.4BGLAP, CALCA, TNFRSF11B, TNFSF11
9ibandronate44 1111.4TNFRSF11B, TNFSF11, CALCA, IBSP, BGLAP
10etidronate4410.3BGLAP, CALCA, TNFRSF11B, SLPI
11denosumab44 1111.3TNFSF11, CALCA, TNFRSF11B
12pamidronate44 49 1112.3TNFSF11, CALCA, BGLAP, PTH, TNFRSF11B
13vitamin k24410.3TNFRSF11B, TNFSF11, BGLAP, CALCA, SLPI
14deoxypyridinoline4410.3PTH, TNFRSF11B, TNFSF11, IBSP, BGLAP, CALCA
15strontium ranelate4410.3TNFSF11, CALCA, IBSP
16risedronate44 59 49 28 1114.3TNFSF11, CALCA, BGLAP, TNFRSF11B, SLPI
17pyridinoline4410.3TNFRSF11B, SLPI, CALCA, IBSP, BGLAP
18titanium4410.3IBSP, TNFSF11, TNFRSF11B, SLPI, BGLAP
19tartrate4410.3BGLAP, CALCR, TNFSF11, SLPI, CALCA
20zoledronic acid4410.2TNFRSF11B, SLPI, TNFSF11, CALCA, IBSP, BGLAP
21hydroxyapatite4410.2BGLAP, SLPI, TNFRSF11B, TNFSF11, IBSP
22alendronate44 49 1112.2PTH, SLPI, TNFRSF11B, TNFSF11, BGLAP, CALCA
23phosphorus4410.2BGLAP, CALCA, PTH, SLPI, TNFRSF11B, TNFSF11
24forskolin44 49 1112.2SP1, CALCA, IBSP, CALCR, PTH
25hydroxyproline44 11 2412.1TNFRSF11B, COL1A1, BGLAP, IBSP, CALCA, SLPI
26simvastatin44 49 59 28 11 2415.1COL1A2, BGLAP, SHBG, IL1RN, SP1, COL1A1
2725-hydroxyvitamin d4410.1SHBG, TNFRSF11B, CALCA, PTH, BGLAP, TNFSF11
28estradiol44 11 2412.1SHBG, PHB2, SLPI, IBSP, SP1, CALCR
29hydrocortisone44 2 59 1113.1TNFRSF11B, CALCA, LCT, SHBG, IL1RN, BGLAP
30estrone44 28 11 2413.1UGT2B17, SHBG, PTH, SP1, BGLAP
31ascorbic acid44 2411.1SLPI, IL1RN, SHBG, TNFRSF11B, TNFSF11, IBSP
32azathioprine44 49 2 1113.1BGLAP, TNFSF11, TNFRSF11B, SP1, SLPI
33tamoxifen44 49 28 1113.0PTH, SLPI, BGLAP, TNFRSF11B, UGT2B17, SHBG
34aspartate4410.0COL1A2, COL1A1, FLT3, SHBG
35cyclosporin a44 28 5911.9BGLAP, CALCA, SLPI, TNFSF11, TNFRSF11B, CALCR
361,25 dihydroxy vitamin d3449.9SP1, CALCR, CALCA, TNFSF11, IBSP, BGLAP
37creatinine449.9IBSP, TNFSF11, CALCR, BGLAP, SLPI, PTH
38cysteine449.9CER1, SP1, SLPI, TNFSF11, IBSP, LCT
39calcitriol44 59 11 2412.9SP1, PTH, SLPI, CALCR, CALCA, TNFSF11
40steroid449.8TNFSF11, SP1, SLPI, SHBG, UGT2B17, TNFRSF11B
41ns 39844 5910.8TNFRSF11B, BGLAP, IL1RN, TNFSF11
42thymidine44 2410.7SLPI, SP1, PTH, FLT3, IBSP, COL1A1
43testosterone44 59 11 2412.7BGLAP, SP1, PTH, SLPI, IL1RN, UGT2B17
44retinoic acid44 2410.7TNFRSF11B, UGT2B17, SLPI, IL1RN, BGLAP, COL1A1
45heparin44 28 11 2412.7TNFRSF11B, BGLAP, IBSP, LCT, TNFSF11, SLPI
46dexamethasone44 49 28 1112.7PTH, SLPI, SP1, IL1RN, SHBG, TNFRSF11B
47vegf449.7IL1RN, SLPI, PTH, IBSP, SP1, BGLAP
48phosphatidylinositol449.6SP1, CALCR, COL1A2, IBSP, TNFSF11, TNFRSF11B
49vitamin d449.5SHBG, TNFRSF11B, TNFSF11, CALCR, CALCA, IBSP
50calcium44 49 11 2412.4IBSP, COL1A1, PTH, SLPI, BGLAP, LCT

GO Terms for genes affiliated with Osteoporotic Fracture

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16Gene Ontology
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Cellular components related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IGO:00558410.3COL1A1, COL1A2
2extracellular spaceGO:0056159.2CALCA, BGLAP, COL1A1, COL1A2, TNFSF11, TNFRSF11B
3extracellular regionGO:0055769.1CER1, COL1A2, COL1A1, BGLAP, IBSP, CALCA

Biological processes related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1skin morphogenesisGO:04358910.4COL1A1, COL1A2
2positive regulation of adenylate cyclase activityGO:04576210.4CALCR, CALCA
3positive regulation of cAMP biosynthetic processGO:03081910.4PTH, CALCR, CALCA
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.4CALCA, CALCR, PTH
5negative regulation of bone resorptionGO:04577910.3CALCA, TNFRSF11B
6response to glucocorticoid stimulusGO:05138410.3BGLAP, CALCR, IL1RN
7protein heterotrimerizationGO:07020810.3COL1A1, COL1A2
8monocyte chemotaxisGO:00254810.3TNFSF11, CALCA
9ossificationGO:00150310.2SP1, TNFSF11, IBSP
10skeletal system developmentGO:00150110.2PTH, TNFRSF11B, BGLAP, COL1A1, COL1A2
11extracellular matrix organizationGO:03019810.0COL1A2, COL1A1, IBSP, TNFRSF11B
12mammary gland alveolus developmentGO:0607499.9PHB2, TNFSF11

Molecular functions related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.3COL1A1, COL1A2

Products for genes affiliated with Osteoporotic Fracture

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  • Antibodies
  • Proteins
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Sources for Osteoporotic Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet