MCID: OST097
MIFTS: 41

Osteoporotic Fracture malady

Bone diseases category
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Summaries for Osteoporotic Fracture

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MalaCards based summary: Osteoporotic Fracture, also known as osteoporotic fractures, is related to osteonecrosis and osteoarthritis. An important gene associated with Osteoporotic Fracture is CER1 (cerberus 1, DAN family BMP antagonist), and among its related pathways are TGF-beta Signaling Pathway and Wnt Signaling Pathway. The compounds calcium carbonate and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are growth/size/body and limbs/digits/tail.

Aliases & Classifications for Osteoporotic Fracture

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Sources:
44Novoseek, 62UMLS
See all sources

Osteoporotic Fracture, Aliases & Descriptions:

Name: Osteoporotic Fracture 44
 
Osteoporotic Fractures 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Related Diseases for Osteoporotic Fracture

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Diseases related to Osteoporotic Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis30.6BGLAP
2osteoarthritis30.3COL1A1, IBSP, BGLAP
3osteoporosis30.1BGLAP, IBSP, PTH, SOST, COL1A1
4breast cancer10.4
5diabetes mellitus10.3
6type 2 diabetes mellitus10.3
7cervicitis10.3
8postural hypotension10.3
9osteosclerosis10.2PTH, SOST
10arthritis10.1
11liver disease10.1
12obesity10.1
13parkinson's disease10.1
14rheumatoid arthritis10.1
15spinal cord injury10.1
16spinal stenosis10.1
17irritable bowel syndrome10.1
18fatty liver disease10.1
19cervical dystonia10.1
20prolactinoma10.1
21hyperprolactinemia10.1
22anorexia nervosa10.1
23empty sella syndrome10.1
24cerebrovascular disease10.1
25dystonia10.1
26back pain10.1
27thromboembolism10.1
28venous thromboembolism10.1
29osteonecrosis of the jaw10.1
30dentinogenesis imperfecta10.1IBSP, COL1A1
31osteogenesis imperfecta type i10.1BGLAP, COL1A1
32pseudohypoparathyroidism type 1b10.0BGLAP, PTH
33idiopathic juvenile osteoporosis10.0COL1A1, BGLAP
34osteitis fibrosa10.0PTH, BGLAP
35pseudohypoparathyroidism10.0PTH, BGLAP
36renal osteodystrophy10.0PTH, BGLAP
37hypophosphatemia10.0PTH, BGLAP
38hypoparathyroidism10.0PTH, BGLAP
39secondary hyperparathyroidism of renal origin10.0BGLAP, PTH
40osteomalacia10.0BGLAP, PTH
41rickets10.0PTH, BGLAP
42fibrous dysplasia10.0IBSP, BGLAP
43ankylosing spondylitis10.0PTH, BGLAP
44goiter10.0BGLAP, PTH
45hyperparathyroidism9.9PTH, BGLAP
46bone cancer9.9BGLAP, IBSP
47metabolic acidosis9.9PTH, BGLAP
48hypercalcemia9.9PTH, BGLAP
49hyperostosis9.9COL1A1, SOST, BGLAP
50hyperthyroidism9.8PTH, BGLAP

Graphical network of the top 20 diseases related to Osteoporotic Fracture:



Diseases related to osteoporotic fracture

Symptoms for Osteoporotic Fracture

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Drugs & Therapeutics for Osteoporotic Fracture

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Drug clinical trials:

Search ClinicalTrials for Osteoporotic Fracture

Search NIH Clinical Center for Osteoporotic Fracture

Genetic Tests for Osteoporotic Fracture

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Anatomical Context for Osteoporotic Fracture

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MalaCards organs/tissues related to Osteoporotic Fracture:

32
Bone, Breast, Testes, Spinal cord, Heart, Liver

Animal Models for Osteoporotic Fracture or affiliated genes

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MGI Mouse Phenotypes related to Osteoporotic Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0COL1A1, CER1, SOST, PTH, IBSP
2MP:00053717.7IBSP, PTH, SOST, CER1, COL1A1
3MP:00053907.5COL1A1, WNT16, CER1, SOST, PTH, IBSP

Publications for Osteoporotic Fracture

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Articles related to Osteoporotic Fracture:

(show top 50)    (show all 294)
idTitleAuthorsYear
1
Bone three-dimensional microstructural features of the common osteoporotic fracture sites. (25232524)
2014
2
Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture. (24764277)
2014
3
Evaluation of the prescription of osteoporosis treatment after a major osteoporotic fracture. (25160027)
2014
4
Incidence and risk of venous thromboembolism among Taiwan osteoporotic fracture population under osteoporosis pharmacological treatments. (24606074)
2014
5
Post-fracture pharmacotherapy for women with osteoporotic fracture: analysis of a managed care population in the USA. (25112720)
2014
6
The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX. (24980183)
2014
7
Performance of risk assessment instruments for predicting osteoporotic fracture risk: a systematic review. (24105431)
2014
8
Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data. (24345885)
2013
9
A glimpse from the past: osteoporosis and osteoporotic fractures in a portuguese identified skeletal sample. (24131908)
2013
10
High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women. (23023015)
2013
11
What was your fracture risk evaluated by FRAXAr the day before your osteoporotic fracture? (23114631)
2013
12
Standard radiography: untapped potential in the assessment of osteoporotic fracture risk. (23187729)
2013
13
Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. (24065012)
2013
14
Role of medicinal plants and natural products on osteoporotic fracture healing. (22973405)
2012
15
Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. (22619194)
2012
16
FRAXAr probabilities and risk of major osteoporotic fracture in France. (22179418)
2012
17
Association between nonalcoholic fatty liver disease (NAFLD) and osteoporotic fracture in middle-aged and elderly Chinese. (22466338)
2012
18
Three-year experience with combined treatment with alendronate and alfacalcidol in Japanese patients with severe bone loss and osteoporotic fracture. (21753888)
2011
19
Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(Ar): a population-based report from CAMOS. (21723768)
2011
20
Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. (20094707)
2010
21
Comparison of a new minimum contact locking plate and the limited contact dynamic compression plate in an osteoporotic fracture model. (19089425)
2009
22
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. (19841454)
2009
23
Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. (18974918)
2009
24
Osteoporotic fracture risk in elderly women: estimation with quantitative heel US and clinical risk factors. (18483227)
2008
25
Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS). (17499570)
2007
26
Measures of renal function, BMD, bone loss, and osteoporotic fracture in older adults: the Rancho Bernardo study. (17059370)
2007
27
The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. (17555504)
2007
28
Digital x-ray radiogrammetry identifies women at risk of osteoporotic fracture: results from a prospective study. (16868669)
2006
29
Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. (16391245)
2006
30
Osteoporotic fractures and vitamin D deficiency. (16820826)
2006
31
Review: developmental origins of osteoporotic fracture. (16331359)
2006
32
Bone tissue compositional differences in women with and without osteoporotic fracture. (16901772)
2006
33
Low femoral bone mineral density and quantitative ultrasound are risk factors for new osteoporotic fracture and total and cardiovascular mortality: a 5-year population-based study of Brazilian elderly women. (16510866)
2006
34
Severity of obstructive airway disease and risk of osteoporotic fracture. (15863646)
2005
35
Thoracic osteoporotic fracture without upper back pain. (15314538)
2004
36
Fracture risk following an osteoporotic fracture. (14691617)
2004
37
Percutaneous vertebroplasty for osteoporotic fracture: preliminary experience at Middlemore Hospital. (15477925)
2004
38
Vertebral assessment using dual-energy X-ray absorptiometry for osteoporotic fracture risk assessment. (15651136)
2004
39
Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. (12810179)
2003
40
The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population. (12730754)
2003
41
Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies. (11792594)
2002
42
Does high intake of vitamin A pose a risk for osteoporotic fracture? (11903019)
2002
43
Reconsidering the effects of antiresorptive therapies in reducing osteoporotic fracture. (11760829)
2001
44
Exercise for prevention of osteoporotic fracture. (11769785)
2001
45
Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. (10752709)
2000
46
Hormonal and biochemical parameters and osteoporotic fractures in elderly men. (10893691)
2000
47
Hormonal predictors of bone loss in elderly women: a prospective study. The Study of Osteoporotic Fractures Research Group. (9661081)
1998
48
Water fluoridation and osteoporotic fracture. (8897754)
1996
49
Calcium intake in the osteoporotic fracture context: introduction. (2053569)
1991
50
Prolactinoma in a middle-aged man with an osteoporotic fracture. (2763547)
1989

Variations for Osteoporotic Fracture

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Expression for genes affiliated with Osteoporotic Fracture

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Expression patterns in normal tissues for genes affiliated with Osteoporotic Fracture

Search GEO for disease gene expression data for Osteoporotic Fracture.

Pathways for genes affiliated with Osteoporotic Fracture

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Compounds for genes affiliated with Osteoporotic Fracture

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Compounds related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1calcium carbonate449.5PTH, BGLAP
2pamidronate44 50 1111.5PTH, BGLAP
3alendronate44 50 1111.4PTH, BGLAP
4glycosaminoglycan449.4IBSP, COL1A1
5ibandronate44 1110.4BGLAP, IBSP
6alizarin449.4IBSP, BGLAP
725-hydroxyvitamin d449.4PTH, BGLAP
8phosphorus449.4BGLAP, PTH
9chitosan449.3IBSP, BGLAP
10titanium449.3BGLAP, IBSP
11zoledronic acid449.3IBSP, BGLAP
12estrone44 28 24 1112.2PTH, BGLAP
13ibmx44 61 2811.2IBSP, PTH
14hydroxyapatite449.2IBSP, BGLAP
15thyroxine44 2410.1PTH, BGLAP
16thymidine44 2410.0COL1A1, PTH, IBSP
17deoxypyridinoline448.9PTH, IBSP, BGLAP
18simvastatin44 50 61 28 24 1113.8COL1A1, BGLAP
19estradiol44 24 1110.8BGLAP, IBSP, PTH
20creatinine448.7BGLAP, IBSP, PTH
21arginine448.6COL1A1, PTH, BGLAP
22hydroxyproline44 24 1110.4COL1A1, PTH, IBSP, BGLAP
23procollagen448.4BGLAP, IBSP, PTH, COL1A1
241,25 dihydroxy vitamin d3448.4BGLAP, IBSP, PTH, COL1A1
25pge2448.3COL1A1, PTH, IBSP, BGLAP
26dexamethasone44 50 28 1111.3BGLAP, IBSP, PTH, COL1A1
27vegf448.3BGLAP, IBSP, PTH, COL1A1
28cysteine448.0BGLAP, IBSP, SOST, CER1, COL1A1
29vitamin d447.9BGLAP, IBSP, PTH, SOST, COL1A1
30estrogen447.9BGLAP, IBSP, PTH, SOST, COL1A1
31calcium44 50 24 1110.8BGLAP, IBSP, PTH, SOST, COL1A1

GO Terms for genes affiliated with Osteoporotic Fracture

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Cellular components related to Osteoporotic Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2IBSP, PTH, CER1, WNT16, COL1A1, BGLAP
2extracellular spaceGO:0056157.1COL1A1, WNT16, CER1, SOST, PTH, BGLAP

Biological processes related to Osteoporotic Fracture according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of BMP signaling pathwayGO:0305149.8CER1, SOST
2Wnt signaling pathwayGO:0160559.6WNT16, SOST
3bone mineralizationGO:0302829.5BGLAP, CER1
4response to vitamin DGO:0332809.3PTH, BGLAP
5ossificationGO:0015039.3IBSP, SOST
6response to mechanical stimulusGO:0096129.3SOST, BGLAP
7cellular response to growth factor stimulusGO:0713639.1BGLAP, IBSP
8osteoblast differentiationGO:0016499.1COL1A1, BGLAP
9skeletal system developmentGO:0015018.8COL1A1, PTH, BGLAP
10response to ethanolGO:0454718.8PTH, BGLAP

Products for genes affiliated with Osteoporotic Fracture

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  • Antibodies
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Sources for Osteoporotic Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet