MCID: OST018
MIFTS: 82

Osteosarcoma malady

Rare diseases, Bone diseases, Cancer diseases categories
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Summaries for Osteosarcoma

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NIH Rare Diseases:42 Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. the average age at diagnosis is 15. boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. in rare cases, osteosarcoma occurs in adults. the cause of osteosarcoma is not known. in some cases, it runs in families, and at least one gene has been linked to increased risk. although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone.a number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal. treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery. last updated: 6/7/2009

MalaCards based summary: Osteosarcoma, also known as osteogenic sarcoma, is related to chondroblastic osteosarcoma and fibrous dysplasia. An important gene associated with Osteosarcoma is TP53 (tumor protein p53), and among its related pathways are DNA damage DNA damage induced responses and PLK3 signaling events. The drugs cisplatin and cisplatin pwdr and the compounds pt 430 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and lung, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:8 A bone cancer that is located in bone that has material basis in cells of mesenchymal origin.

Wikipedia:65 Osteosarcoma is a cancerous bone tumor. Specifically, it is an aggressive malignant neoplasm--arising... more...

Description from OMIM:46 259500

Aliases & Classifications for Osteosarcoma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet
See all sources

Osteosarcoma, Aliases & Descriptions:

Name: Osteosarcoma 8 9 42 22 46 10 44 48 62
Osteogenic Sarcoma 8 42 48
Skeletal Sarcoma 8 62
Osteoid Sarcoma 8 62
 
Neoplasms, Bone Tissue 62
Bone Tissue Neoplasm 8
Sarcoma, Osteogenic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
osteosarcoma:
Prevalence: 1-9/100000; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:3347
OMIM46 259500
MeSH34 D012516
NCIt39 C9145
ICD10 via Orphanet26 C40, C41
UMLS via Orphanet63 C0029463
MESH via Orphanet35 D012516

Related Diseases for Osteosarcoma

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Diseases in the Osteosarcoma family:

Localized Osteosarcoma

Diseases related to Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1chondroblastic osteosarcoma31.9BGLAP
2fibrous dysplasia31.3BGLAP, FOS
3retinoblastoma31.3TP53, CHEK2, DHFR, FOS, RB1, MDM2
4paget's disease of bone31.3TNFRSF11A
5sarcoma31.2CD99, MDM2, RB1, TWIST1, FOLR1, DHFR
6rhabdomyosarcoma31.1EZR, TP53, RB1, MDM2, CD99
7liposarcoma31.0TP53, TSPAN31, RB1, MDM2
8li-fraumeni syndrome31.0TP53, CHEK2, RB1, MDM2
9osteosarcoma, somatic31.0RB1, CHEK2
10fibrosarcoma30.9MDM2, FOS, DHFR
11leiomyosarcoma30.9MDM2, RB1, TP53
12meningioma30.8EZR
13bone cancer30.7BGLAP, TNFRSF11A, EZR, RB1, MDM2
14transitional cell carcinoma30.7MDM2, RB1, TP53
15breast cancer30.6EZR, TP53, CHEK2, DHFR, FOS, TWIST1
16osteofibrous dysplasia30.6BGLAP
17giant cell tumor30.6TNFRSF11A, BGLAP
18leukemia30.5TP53, CHEK2, DHFR, FOLR1, FOS, RB1
19alveolar rhabdomyosarcoma30.5RB1, MDM2
20adenocarcinoma30.5MDM2, RB1, FOLR1, CHEK2, TP53, EZR
21melanoma30.4EZR, TP53, CHEK2, DHFR, RB1, MDM2
22acute lymphoblastic leukemia30.4DHFR, FOS, RB1, SLC19A1
23prostate cancer30.4RB1, FOS, CHEK2, EZR, BGLAP
24ataxia telangiectasia30.4TP53, CHEK2, DHFR, MDM2
25astrocytoma30.4EZR, TP53, FOS, RB1, MDM2
26cervical cancer30.3MDM2, RB1, TP53
27glioblastoma30.3EZR, TP53, CHEK2, FOS, RB1, MDM2
28lung cancer30.3TP53, CHEK2, DHFR, FOS, RB1, MDM2
29liver cancer30.2EZR, TP53, FOS, TWIST1, RB1, MDM2
30pediatric osteosarcoma10.7
31multifocal osteogenic sarcoma10.6
32cerebral primitive neuroectodermal tumor10.6CD99
33localized osteosarcoma10.6
34chondrosarcoma10.6
35extraosseous osteosarcoma10.6
36retinoblastoma fa - friedreich ataxia10.5MDM2, RB1
37chondroma10.5TSPAN31
38peripheral primitive neuroectodermal tumor10.5CD99
39megaloblastic anemia10.5DHFR
40dedifferentiated liposarcoma10.5RB1, MDM2
41malignant fibroxanthoma10.5TSPAN31, TP53
42saethre-chotzen syndrome10.5BGLAP, TWIST1
43giant cell glioblastoma10.5MDM2
44osteoblastoma10.5
45ependymoma10.5EZR, RB1, MDM2
46grade iii astrocytoma10.5MDM2, RB1, TP53
47secondary syphilis10.5FOS, TNFRSF11A, BGLAP
48juxtacortical osteosarcoma10.5
49folic acid deficiency anemia10.5DHFR, FOLR1, SLC19A1
50oral cancer10.5MDM2, RB1, TP53

Graphical network of the top 20 diseases related to Osteosarcoma:



Diseases related to osteosarcoma

Symptoms for Osteosarcoma

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Clinical features from OMIM:

259500

Drugs & Therapeutics for Osteosarcoma

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Drug clinical trials:

Search ClinicalTrials for Osteosarcoma

Search NIH Clinical Center for Osteosarcoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Osteosarcoma

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Genetic tests related to Osteosarcoma:

id Genetic test Affiliating Genes
1 Osteosarcoma22

Anatomical Context for Osteosarcoma

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MalaCards organs/tissues related to Osteosarcoma:

32
Bone, Lung, Breast, Endothelial, Liver, Thyroid, Prostate, Colon, Kidney, Monocytes, Ovary, T cells, Bone marrow, Smooth muscle, Nk cells, Lymph node, Brain, Spinal cord, Heart, Small intestine, Pancreas, Adrenal gland, Skin, Uterus, Testes, Cervix

FMA organs/tissues related to Osteosarcoma:

14
Bone

Animal Models for Osteosarcoma or affiliated genes

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Publications for Osteosarcoma

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Articles related to Osteosarcoma:

(show top 50)    (show all 2165)
idTitleAuthorsYear
1
Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. (24247158)
2014
2
Anti-Tumor Necrosis Factor Therapy Inhibits Lung Metastasis in an Osteosarcoma Cell Line. (25402182)
2014
3
Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases. (24795337)
2014
4
Matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the Akt pathway. (25371071)
2014
5
MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell. (23740615)
2013
6
Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. (24129234)
2013
7
p38 MAPK regulates the expression of ether A go-go potassium channel in human osteosarcoma cells. (23450231)
2013
8
MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects. (23797816)
2013
9
Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells. (23129219)
2013
10
miRNA-218 inhibits osteosarcoma cell migration and invasion by down-regulating of TIAM1, MMP2 and MMP9. (23886165)
2013
11
Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia. (24147271)
2013
12
Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. (21890444)
2012
13
A case of parosteal osteosarcoma with a rare complication of myositis ossificans. (23194024)
2012
14
Effect of C23 down-regulation on proliferation inhibition and apoptosis induced by cisplatin in human osteosarcoma SaOS-2 cells]. (22349377)
2012
15
TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. (22021909)
2012
16
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. (22659570)
2012
17
WEE1 inhibition sensitizes osteosarcoma to radiotherapy. (21529352)
2011
18
Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX. (21310198)
2011
19
miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. (22093834)
2011
20
Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. (19896763)
2010
21
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. (20399482)
2010
22
Expression of heat shock proteins in osteosarcomas. (20632817)
2010
23
Interleukin 24 inhibits growth and induces apoptosis of osteosarcoma cells MG-63 in vitro and in vivo]. (20112699)
2009
24
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. (19441093)
2009
25
Down-regulation of ribosomal protein L7A in human osteosarcoma. (19125294)
2009
26
Radiosensitivity of canine osteosarcoma cells transfected with wild-type p53 in vitro. (19178679)
2008
27
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases. (18298897)
2008
28
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. (18559481)
2008
29
TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. (17483704)
2007
30
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. (17279585)
2007
31
Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. (17684144)
2007
32
The retinoblastoma protein in osteoblast differentiation and osteosarcoma. (17100605)
2006
33
Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? (16786118)
2006
34
Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. (15946696)
2005
35
Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. (15796961)
2005
36
Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. (16380506)
2005
37
Rothmund-Thomson syndrome, Klippel-Feil syndrome, and osteosarcoma. (15197508)
2004
38
Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. (12802802)
2003
39
Intradural primary chondroblastic osteosarcoma: case report. (11733332)
2001
40
Isolation, identification and biological activity of 24R,25-dihydroxy-3-epi-vitamin D3: a novel metabolite of 24R,25-dihydroxyvitamin D3 produced in rat osteosarcoma cells (UMR 106). (11508700)
2001
41
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
42
Hormones, autocrine and paracrine regulators of tumor growth in osteosarcoma]. (11383452)
2001
43
Phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cells. (11018472)
2000
44
Chondroblastoma-like osteosarcoma. (10192265)
1999
45
Comparative genomic hybridization of low-grade central osteosarcoma. (9619593)
1998
46
Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. (9404699)
1997
47
Relationship between the induction of heat shock proteins and the decrease in glucocorticoid receptor during heat shock response in human osteosarcoma cells. (8745575)
1995
48
Transforming growth factor-beta modulates eicosanoid metabolism in osteogenic osteosarcoma cells. (1908241)
1991
49
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
50
Osteosarcoma in a boy with Rothmund-Thomson syndrome. (6932639)
1980

Variations for Osteosarcoma

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Clinvar genetic disease variations for Osteosarcoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.722C> T (p.Ser241Phe)single nucleotide variantLikely pathogenicrs28934573GRCh37Chr 17, 7577559: 7577559
2TP53TP53, 7-BP INS, NT13160insertionPathogenic
3CHEK2NM_007194.3(CHEK2): c.49G> T (p.Ala17Ser)single nucleotide variantPathogenicrs137853008GRCh37Chr 22, 29130661: 29130661

Expression for genes affiliated with Osteosarcoma

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Expression patterns in normal tissues for genes affiliated with Osteosarcoma

Search GEO for disease gene expression data for Osteosarcoma.

Pathways for genes affiliated with Osteosarcoma

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Pathways related to Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CHEK2, TP53
210.3CHEK2, TP53
310.3TP53, OS9
4
Show member pathways
10.3MDM2, TP53
5
Show member pathways
10.2SLC19A1, FOLR1
6
Show member pathways
10.2RB1, CHEK2, TP53
7
Show member pathways
10.2RB1, FOS, TP53
810.2TP53, FOS, RB1
910.2CHEK2, FOS, RB1
10
Show member pathways
DNA damage Role of SUMO in p53 regulation60
10.2TP53, CHEK2, MDM2
11
Show member pathways
ATM Signaling Pathway37
10.2MDM2, CHEK2, TP53
1210.2TP53, CHEK2, MDM2
13
Show member pathways
p53 pathway37
10.2TP53, CHEK2, MDM2
14
Show member pathways
10.2MDM2, CHEK2, TP53
1510.2TP53, FOS, MDM2
16
Show member pathways
Signal transduction PTEN pathway60
10.2TP53, FOS, MDM2
17
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
10.2TP53, FOS, MDM2
18
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.2MDM2, FOS, TP53
1910.2TP53, RB1, MDM2
20
Show member pathways
10.2TP53, RB1, MDM2
2110.2TP53, RB1, MDM2
2210.2MDM2, RB1, TP53
2310.2MDM2, RB1, TP53
24
Show member pathways
10.2MDM2, RB1, FOS
2510.1BGLAP, RB1, MDM2
2610.1BGLAP, TNFRSF11A, FOS
2710.1BGLAP, TWIST1, RB1
28
Show member pathways
Immune response MIF in innate immunity response60
10.1TP53, FOS, FOSB
29
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
10.1TP53, FOS, FOSB
3010.1FOSB, FOS, TNFRSF11A
3110.1TP53, CHEK2, FOS, RB1
3210.1TP53, CHEK2, RB1, MDM2
33
Show member pathways
DNA damage response37
10.1TP53, CHEK2, RB1, MDM2
34
Show member pathways
Cell cycle37
10.1TP53, CHEK2, RB1, MDM2
35
Show member pathways
10.1MDM2, RB1, CHEK2, TP53
3610.1MDM2, RB1, FOS, TP53
3710.1MDM2, RB1, FOS, TP53
38
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
10.1TNFRSF11A, TP53, FOS, RB1
3910.1BGLAP, TP53, FOS, MDM2
40
Show member pathways
10.0TP53, DHFR, RB1, MDM2
4110.0TP53, DHFR, RB1, MDM2
4210.0TP53, FOS, FOSB, RB1
4310.0MDM2, TWIST1, TP53, EZR
44
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.0TP53, CHEK2, FOS, RB1, MDM2
45
Show member pathways
10.0TP53, CHEK2, FOS, RB1, MDM2
46
Show member pathways
10.0TP53, CHEK2, FOS, RB1, MDM2
47
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.9TP53, CHEK2, XRN1, RB1, MDM2
48
Show member pathways
9.8BGLAP, TP53, CHEK2, DHFR, RB1, MDM2
49
Show member pathways
9.8MDM2, RB1, FOSB, FOS, CHEK2, TP53
50
Show member pathways
9.7TNFRSF11A, TP53, CHEK2, FOS, FOSB, RB1

Compounds for genes affiliated with Osteosarcoma

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Compounds related to Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1pt 4304410.6DHFR, SLC19A1
2metoprine4410.6DHFR, SLC19A1
3bpde4410.6TP53, CHEK2, MDM2
4ag 3314410.6DHFR, SLC19A1
5ag 3374410.6DHFR, SLC19A1
6pt5234410.5DHFR, SLC19A1
7trimetrexate44 1111.5SLC19A1, FOLR1, DHFR
8aflatoxin b144 2411.5TP53, RB1, MDM2
9folic acid50 24 1112.5SLC19A1, FOLR1, DHFR
10aphidicolin4410.5TP53, CHEK2, DHFR, RB1
11n-hydroxysuccinimide4410.5SLC19A1, FOLR1
12ag 20344410.5SLC19A1, DHFR
13tomudex4410.5TP53, DHFR, FOLR1, SLC19A1
14carboplatin44 50 1112.4SLC19A1, MDM2, RB1, TP53
15dihydrofolate4410.4DHFR, FOLR1, RB1, SLC19A1
16vincristine44 50 1112.4SLC19A1, MDM2, RB1, TP53
17camptothecin44 61 1112.4MDM2, RB1, CHEK2, TP53
18adriamycin4410.4TP53, CHEK2, DHFR, RB1, MDM2
19mitomycin c4410.4BGLAP, TP53, DHFR, RB1, MDM2
20hdmtx4410.3DHFR, SLC19A1
21cyclophosphamide44 50 1112.3TP53, DHFR, RB1, MDM2
22etoposide44 50 61 1113.3TP53, CHEK2, DHFR, RB1, MDM2
235-aza-2deoxycytidine4410.3SLC19A1, MDM2, FOLR1, TP53
24leucovorin44 50 1112.3SLC19A1, FOLR1, DHFR
25arsenite44 2411.3TP53, DHFR, FOS, MDM2
265fluorouracil4410.3SLC19A1, MDM2, RB1, DHFR, TP53
27roscovitine4410.3MDM2, RB1, TP53
28geneticin4410.3DHFR, FOS
29methotrexate50 44 1112.3DHFR, FOLR1, RB1, MDM2, SLC19A1
30calcitriol44 61 24 1113.3BGLAP, TNFRSF11A, FOS, RB1
31ly2940024410.3MDM2, RB1, FOS, TP53, EZR
32genistein44 28 61 2 24 1115.2EZR, CHEK2, FOS, RB1, MDM2
331843u894410.2DHFR, SLC19A1
34h2o24410.2BGLAP, TP53, DHFR, FOS, RB1, MDM2
35okadaic acid44 6111.2CHEK2, FOS, FOSB, RB1
36benzo(a)pyrene4410.2MDM2, RB1, TP53
37paraffin4410.2BGLAP, EZR, TP53, RB1, MDM2, CD99
38thymidylate4410.2SLC19A1, TP53, DHFR, FOLR1, FOS, RB1
39n-phosphonacetyl-l-aspartate4410.2DHFR, TP53
40doxorubicin44 50 1112.2TP53, CHEK2, DHFR, FOLR1, RB1, MDM2
41paclitaxel44 50 1112.1TP53, DHFR, FOLR1, TWIST1, RB1, MDM2
42oligonucleotide4410.1TP53, CHEK2, FOLR1, FOS, FOSB, RB1
43vegf4410.1BGLAP, TNFRSF11A, TP53, FOS, RB1, MDM2
44phosphatidylinositol4410.1TNFRSF11A, EZR, CHEK2, FOLR1, FOS, RB1
45cisplatin44 50 61 1113.0BGLAP, TP53, CHEK2, DHFR, FOLR1, RB1
46alanine4410.0BGLAP, EZR, CHEK2, DHFR, MDM2, SLC19A1
47lometrexol449.9FOLR1, SLC19A1
48estrogen449.8BGLAP, TNFRSF11A, EZR, TP53, DHFR, FOS
49tyrosine449.7TNFRSF11A, EZR, CHEK2, AKAP12, FOS, FOSB
50serine449.5BGLAP, TNFRSF11A, EZR, TP53, CHEK2, DHFR

GO Terms for genes affiliated with Osteosarcoma

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Cellular components related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:01660510.2RB1, CHEK2, TP53
2nucleoplasmGO:0056549.5CTDSP2, MDM2, RB1, FOS, CHEK2, TP53

Biological processes related to Osteosarcoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to gravityGO:00962910.5FOS, BGLAP
2folic acid transportGO:01588410.5SLC19A1, FOLR1
3replicative senescenceGO:09039910.5TP53, CHEK2
4folic acid metabolic processGO:04665510.5SLC19A1, FOLR1
5regulation of protein catabolic processGO:04217610.4MDM2, CHEK2
6negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.4TWIST1, MDM2
7response to mechanical stimulusGO:00961210.4FOSB, FOS, BGLAP
8cellular response to hypoxiaGO:07145610.4TP53, TWIST1, MDM2
9regulation of bone mineralizationGO:03050010.4BGLAP, TWIST1
10response to drugGO:04249310.2MDM2, FOSB, FOS, BGLAP
11response to corticosteroneGO:05141210.2FOS, FOSB
12positive regulation of gene expressionGO:01062810.1MDM2, TWIST1, EZR
13response to morphineGO:04327810.1MDM2, FOSB
14positive regulation of transcription, DNA-templatedGO:04589310.1RB1, FOS, CHEK2, TP53
15cell agingGO:00756910.0TP53, BGLAP

Molecular functions related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:00851710.1SLC19A1, FOLR1
2ubiquitin protein ligase bindingGO:03162510.1TP53, CHEK2, RB1, MDM2
3identical protein bindingGO:04280210.1MDM2, RB1, CHEK2, TP53
4transcription factor bindingGO:00813410.0RB1, TWIST1, FOSB, FOS, TP53
5folic acid bindingGO:0055429.9FOLR1, SLC19A1
6protein bindingGO:0055159.0CHEK2, TP53, OS9, EZR, TNFRSF11A, AKAP12

Products for genes affiliated with Osteosarcoma

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Sources for Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet