Osteosarcoma malady

NIH Rare Diseases: Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. In rare cases, osteosarcoma occurs in adults. The cause of osteosarcoma is not known. In some cases, it runs in families, and at least one gene has been linked to increased risk. Although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone. A number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal. Treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery.³⁰

MalaCards: Osteosarcoma, also known as osteogenic sarcoma, is related to carcinoma and prostatitis. An important gene associated with Osteosarcoma is OS9 (osteosarcoma amplified 9, endoplasmic reticulum lectin), and among its related pathways are Molecular Mechanisms of Cancer and p38 Signaling. The drugs cisplatin and methotrexate and the compounds calcium and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, smooth muscle and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia: Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal...⁴⁴ more...

OMIM: 259500

Aliases & Descriptions:

osteosarcoma 6 7 30 33 8 32 43 osteogenic sarcoma 6 30 osteosarcoma, no icd-o subtype (morphologic abnormality) 6 osteosarcoma - disorder 6 neoplasms, bone tissue 43

bone tissue neoplasm 6 skeletal sarcoma 6 osteoid sarcoma 6 bone sarcoma 43

Diseases related to osteosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 861)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	105.7	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, RFC1
2	prostatitis	92.0	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, RFC1
3	leukemia	85.9	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, RFC1
4	melanoma	77.9	PIK3CB, PIK3CA, PIK3CG, PDE1C, PDE3A, PDE3B
5	hepatitis	75.5	PIK3CB, PIK3CA, PIK3CG, PDE3B, PDE4C, RELA
6	hepatocellular carcinoma	72.8	PIK3CB, PIK3CA, PIK3CG, RECK, RELA, REV3L
7	colon cancer	71.2	PIK3CB, PIK3CA, PIK3CG, RFC1, PDE2A, PDE4A
8	sarcoma	71.2	ZNF395, PIK3CB, PIK3CA, PIK3CG, NCOA1, PDE4A
9	neuroblastoma	69.2	PIK3CB, PIK3CA, PIK3CG, NCOA1, PDE1C, PDE3B
10	hypoxia	69.2	PIK3CB, PIK3CA, PIK3CG, LRP5, NCOA1, PDE4A
11	thyroiditis	68.9	PIK3CB, PIK3CA, PIK3CG, KLF10, RFC1, NCOA1
12	cervicitis	66.6	PIK3CA, PIK3CG, RFC1, PDE4A, RECK, RECQL4
13	breast carcinoma	64.7	PIK3CA, PIK3CG, RECK, KIT, VWF, VTN
14	retinoblastoma	58.2	PIK3CB, PIK3CA, PIK3CG, RFC1, PDE3B, RECK
15	cervical cancer	51.9	PIK3CA, PIK3CG, RFC1, RECQL4, RELA, VTN
16	rhabdomyosarcoma	51.0	NCOA1, CNR1, PCNA, RB1, VIM, VEGFA
17	pancreatitis	50.1	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, PDE3B
18	adenocarcinoma	49.3	PIK3CB, PIK3CA, PIK3CG, KLF10, NCOA1, PDE2A
19	neuronitis	48.2	ZNF395, PIK3CB, PIK3CA, PIK3CG, KLF10, NCOA1
20	colorectal cancer	45.0	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, RFC1
21	acute leukemia	45.0	PIK3CA, KIT, VWF, RB1, SERPINC1, VEGFA
22	fibrosarcoma	44.4	PIK3CG, RECK, KIT, VTN, RB1, SETD2
23	chondrosarcoma	44.1	PIK3CB, PIK3CG, RB1, VIM, VEGFA, MYOG
24	gingivitis	42.7	PIK3CG, CNR1, PCNA, SETD2, SERPINF1, SERPINE1
25	gastric cancer	41.2	PIK3CB, PIK3CA, PIK3CG, RFC1, RECK, RELA
26	herpes simplex	41.1	PIK3CA, PIK3CG, RECK, REV3L, PCNA, GC
27	lung carcinoma	39.5	PIK3CA, PIK3CG, RECK, PCNA, RB1, RBL2
28	soft tissue sarcoma	38.5	KIT, PCNA, RB1, RBL2, SERPINE1, VIM
29	squamous cell carcinoma	38.4	PIK3CB, PIK3CA, RECK, RELA, VTN, PCNA
30	adenoma	37.2	PIK3CA, NCOA1, PDE4A, RECK, CNR1, KIT
31	pediatric osteosarcoma	37.0	RFC1, RB1, MTHFR, MTR, CDKN2A, FOLR1
32	esophagitis	36.9	PIK3CB, PIK3CA, PIK3CG, PDE4A, RECK, RELA
33	gonococcal synovitis	36.7	PIK3CB, PIK3CA, PIK3CG, NCOA1, PDE3B, PDE4A
34	rheumatoid arthritis	36.7	PIK3CG, LRP5, RFC1, PDE4A, RECK, RELA
35	histiocytoma	36.5	PCNA, RB1, VIM, VEGFA, LPL, MYOG
36	choroiditis	36.4	PIK3CG, VWF, VTN, PCNA, RBL1, SETD2
37	fibrous histiocytoma	36.3	PCNA, RB1, VIM, VEGFA, LPL, MYOG
38	ovarian carcinoma	36.2	PIK3CA, PIK3CG, RECK, RELA, REV3L, KIT
39	myeloma	35.7	PIK3CA, PIK3CG, LRP5, PDE4A, RECK, RELA
40	malignant fibrous histiocytoma	35.6	PCNA, RB1, VIM, VEGFA, LPL, MYOG
41	myeloid leukemia	35.0	PIK3CB, PIK3CA, PIK3CG, LRP5, RECK, RELA
42	pertussis	34.9	PIK3CG, PDE4A, RELA, CNR1, LPAR1, LPAR3
43	fibrosis	33.4	PIK3CA, PIK3CG, PDE3A, PDE4A, RECK, RELA
44	colon carcinoma	33.0	PIK3CB, PIK3CA, PIK3CG, PDE1A, REV3L, CNR1
45	alzheimer's disease	32.8	PIK3CB, PIK3CA, PIK3CG, RFC1, PDE4A, RECK
46	liposarcoma	32.6	RELA, KIT, RB1, VIM, VEGFA, LPL
47	retinitis	32.5	PIK3CA, PIK3CG, LRP5, PDE2A, PDE3B, PDE4A
48	adrenocortical carcinoma	32.4	RB1, BMP2, BMP5, CHKA, MVP, S100B
49	breast cancer	32.1	RECK, BRCA1, VEGFA, VDR, USP1, BCL2
50	myositis	32.1	VIM, VCP, MYOD1, BMP1, CLU, BCL2

Clinical features from OMIM: 259500

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carboplatin, cisplatin, cisplatin pwdr [va product], methotrexate, methotrexate sodium

MalaCards organs/tissues related to osteosarcoma:

²²

MGI Mouse Phenotypes related to osteosarcoma:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	37.1	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, NCOA1
2	cellular phenotype	MP:0005384	37.0	PIK3CB, PIK3CA, PIK3CG, LRP5, KLF10, PDE4B
3	mortality/aging	MP:0010768	36.6	PIK3CB, PIK3CA, LRP5, PDE2A, PDE4B, RECK
4	growth/size phenotype	MP:0005378	34.1	PIK3CB, PIK3CA, PIK3CG, NCOA1, PDE3B, RECK
5	cardiovascular system phenotype	MP:0005385	30.5	PIK3CB, PIK3CA, PIK3CG, LRP5, PDE4A, PDE4B
6	nervous system phenotype	MP:0003631	30.3	LRP5, NCOA1, PDE4A, PDE4B, RECK, RELA
7	skeleton phenotype	MP:0005390	26.8	PIK3CG, KLF10, NCOA1, RECK, RELA, CNN1
8	behavior/neurological phenotype	MP:0005386	25.7	PIK3CA, LRP5, NCOA1, CNR1, KIT, KIF2A
9	hematopoietic system phenotype	MP:0005397	25.4	RECQL4, REV3L, KIT, PCNA, RB1CC1, RBL1
10	immune system phenotype	MP:0005387	24.4	LRP5, NCOA1, PDE4A, PDE4B, RECQL4, REV3L
11	muscle phenotype	MP:0005369	24.0	PIK3CA, PIK3CG, RELA, KIT, BUB3, RB1
12	normal phenotype	MP:0002873	23.4	LRP5, PDE3A, RELA, VTN, RBL2, RB1CC1
13	integument phenotype	MP:0010771	23.2	PIK3CG, KLF10, NCOA1, PDE3B, RECK, RECQL4
14	embryogenesis phenotype	MP:0005380	22.8	PIK3CB, PIK3CA, LRP5, NCOA1, RECK, RECQL4
15	vision/eye phenotype	MP:0005391	22.2	PIK3CA, LRP5, RECQL4, RELA, KIT, BUB3
16	digestive/alimentary phenotype	MP:0005381	22.0	RECQL4, KIT, VWF, RB1, RBL1, SERPINF1
17	limbs/digits/tail phenotype	MP:0005371	21.5	LRP5, KLF10, RECK, RECQL4, RELA, CNN1
18	renal/urinary system phenotype	MP:0005367	20.5	NCOA1, SGK1, KIT, BRCA1, MYCN, BMP4
19	reproductive system phenotype	MP:0005389	20.3	PIK3CA, NCOA1, PDE3A, RBL2, RBL1, SERPINF1
20	tumorigenesis	MP:0002006	19.5	PIK3CB, PIK3CA, KLF10, RECQL4, REV3L, KIT
21	craniofacial phenotype	MP:0005382	18.9	LRP5, RECQL4, REV3L, KIT, RBL1, LPAR1
22	hearing/vestibular/ear phenotype	MP:0005377	18.0	KIT, RB1, VDR, MYC, BMP2, BMP4
23	no phenotypic analysis	MP:0003012	16.6	SGK1, CNR1, PCNA, RB1, RBL2, RB1CC1
24	liver/biliary system phenotype	MP:0005370	15.2	LRP5, RECK, KIT, RB1CC1, RBL1, SERPINC1
25	endocrine/exocrine gland phenotype	MP:0005379	15.1	LRP5, NCOA1, RBL2, RBL1, BRCA1, BMP5
26	respiratory system phenotype	MP:0005388	15.1	BRCA1, LPL, MYCN, MYOG, MYOD1, BMP5
27	adipose tissue phenotype	MP:0005375	15.0	PIK3CA, PDE3B, CNR1, BUB3, RB1, RBL1
28	pigmentation phenotype	MP:0001186	13.7	LRP5, PDE3B, RECQL4, KIT, RB1, SERPINC1
29	other phenotype	MP:0005395	13.3	RECK, CNR1, RARA, CLU, LEPR, LDLR
30	taste/olfaction phenotype	MP:0005394	11.5	PDE1C, PDE4A, CNR1, ENO2, MAPK1, ID2

Articles related to osteosarcoma:

(show top 50)    (show all 1120)

id	Title	Authors	Year	Affiliating Genes
1	Wnt inhibitory factor 1 decreases tumorigenesis and m etastasis in osteosarcoma. (20197388)	Rubin E.M.... Hoang B.H.	2010	WIF1
2	Functional elucidation of MiR-34 in osteosarcoma cell s and primary tumor samples. (19632201)	He C.... Wang D.	2009	MIR34A, MIR34B, MIR34C
3	Orphan receptor tyrosine kinase ROR2 as a potential t herapeutic target for osteosarcoma. (19486338)	Morioka K.... Matsuda K.	2009	WNT5B, ROR2
4	Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. (19917123)	Susa M.... Duan Z.	2009	ABCB1
5	Osteosarcoma: the European Osteosarcoma Intergroup (E OI) perspective. (20213395)	Craft A.W.	2009	CSF3
6	met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma. (19402129)	De Maria R.... Di Renzo M.F.	2009	MET
7	Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma. (18271936)	Tsukahara T.... Sato N.	2008	ZNF395
8	Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells. (18448670)	Ma H.... Pederson T.	2008	NPM1, GNL3
9	Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. (18925963)	Veselska R.... Sterba J.	2008	NES
10	Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma. (17951400)	Koshkina N.V.... Kleinerman E.S.	2007	FAS, FASLG
11	Osteosarcoma cell line growth inhibition by zoledrona te-stimulated effector cells. (18163982)	Muraro M.... Fagioli F.	2007	IL2
12	Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. (18090928)	Koshkina N.V.... Sturgis E.M.	2007	FAS
13	Improvement in histologic response but not survival i n osteosarcoma patients treated with intensified chemotherapy: a randomized pha se III trial of the European Osteosarcoma Intergroup. (17227995)	Lewis I.J.... Taminiau A.H.	2007	CSF3
14	RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells. (16328004)	Wittrant Y.... Redini F.	2006	TNFRSF11A
15	Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. (16677779)	Park H.R.... Park Y.K.	2006	EZR
16	Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. (17089020)	Ohata N.... Ouchida M.	2006	CCNC
17	Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. (15540114)	Watanabe K.... Yonehara S.	2005	CASP8, HDAC9, CFLAR
18	Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. (15049011)	Cheng Y.Y.... Kumta S.M.	2004	MMP2
19	Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone/kidney alkaline phosphatase gene. (15050898)	Zucchini C.... Scotlandi K.	2004	CAV1, CDH13
20	Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. (15201972)	Lee W.I.... Park Y.K.	2004	ERBB2
21	HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. (15069760)	Tsai J.Y.... Hameed M.	2004	TP53
22	Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. (15390294)	Khayat C.M.... Johnston D.L.	2004	TP53
23	Mutation analysis of the apoptotic 'death-receptors' and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. (14999771)	Dechant M.J.... Debatin K.M.	2004	TNFRSF1A, TNFRSF10A
24	Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. (15210853)	Wang D.... Kelley M.R.	2004	APEX1
25	Mineralization of matrix vesicles isolated from a hum an osteosarcoma cell line in culture with water-soluble chitosan-containing med ium. (12918032)	Yamada S.... Hayashi Y.	2003	BMP2, ALPP
26	Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma. (11895909)	Garcia-Castellano J.M.... Gorlick R.	2002	MTAP
27	Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)	Gokgoz N.... Andrulis I.L.	2001	TP53
28	Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. (11464280)	Zhang Y.W.... Murota S.	2001	GJA1
29	Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma. (10762653)	Tanaka M.... Uchida A.	2000	TNC
30	Improving the cytometric detection of doxorubicin resistance in osteosarcoma cells by determining cellular doxorubicin/DNA ratio. (10697541)	Takeshita H.... Hirasawa Y.	1999	ABCB1
31	Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir. (10226527)	Charissoux J.L.... Rigaud M.	1999	TK1
32	Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. (10403379)	Nakayama T.... Sakata T.	1999	OS9, CPNE6
33	Comparative genomic hybridization of low-grade central osteosarcoma. (9619593)	Tarkkanen M.... Knuutila S.	1998	CDK4
34	p53 gene mutations in osteosarcomas of low-grade malignancy. (9824113)	Radig K.... Roessner A.	1998	TP53
35	Different expression pattern of cytokine receptors by human osteosarcoma cell lines. (9499453)	Lisignoli G.... Facchini A.	1998	IL18R1
36	An in vivo/in vitro experimental model system for the study of human osteosarcoma: canine osteosarcoma cells (COS31) which retain osteoblastic and metastatic properties in nude mice. (9827352)	Shoieb A.M.... Barnhill M.A.	1998	BGLAP
37	Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. (9771482)	Franchi A.... Zampi G.	1998	TGFB1, TGFB2, BMP6
38	P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. (9390540)	Chan H.S.... Ling V.	1997	ABCB11
39	Composition and posttranslational modification of individual collagen chains from osteosarcomas and osteofibrous dysplasias. (7635871)	Lehmann H.W.... MA1ller P.K.	1995	CD36
40	The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. (7541624)	Carvalho R.S.... Yen E.H.	1995	ITGB1
41	Doxorubicin and cisplatin with granulocyte colony-sti mulating factor as adjuvant chemotherapy for osteosarcoma: phase II trial of th e European Osteosarcoma Intergroup. (7521906)	Ornadel D.... Bridgewater J.	1994	CSF3
42	Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. (8050825)	Kloen P.... Mankin H.J.	1994	TGFB1, BMP6
43	Target gene activation by 1,25-dihydroxyvitamin D3 in osteosarcoma cells is independent of calcium influx. (7988430)	Khoury R.... Farach-Carson M.C.	1994	SPP1
44	Interaction of parathyroid hormone-related peptide-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: role in PTHrP-induced homologous desensitization. (8386430)	Sugimoto T.... Chihara K.	1993	PTHLH
45	Induction of HLA class II antigens in osteosarcoma cells by interferons and tumor necrosis factor alpha. (1622136)	Scotlandi K.... Serra M.	1992	IFNB1
46	A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. (1469057)	Kargman S.... Evans J.F.	1992	ALOX5AP, ALOX5
47	Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. (1423318)	Reuvekamp P.T.... Buys C.H.	1992	TP53, RB1
48	A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas. (1336709)	Hovig E.... rresen A.L.	1992	RB1, TP53
49	Characterization of a new human osteosarcoma cell line OHS-4. (1860886)	Fournier B.... Price P.A.	1991	CALCA, BGLAP
50	Thrombospondin binds to the surface of human osteosarcoma cells and mediates platelet-osteosarcoma cell interaction. (1708697)	Clezardin P.... Delmas P.D.	1991	THBS1, ADAMTSL1

Genes related to osteosarcoma according to GeneCards:

(show top 50)    (show all 740)

id	Symbol	Description	Score	GeneCards Section Context
1	OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	11.1	Functions, Transcripts, Expressions, Publications (show all 7 sections) Aliases & Descriptions, Orthologs, Summaries
2	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Transcripts, Publications, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
3	RB1	retinoblastoma 1	11.0	Publications, Aliases & Descriptions
4	TSPAN31	tetraspanin 31	11.0	Publications, Summaries
5	CD99	CD99 molecule	11.0	Publications, Summaries
6	AKAP12	A kinase (PRKA) anchor protein 12	11.0	Expressions, Summaries
7	FOSB	FBJ murine osteosarcoma viral oncogene homolog B	11.0	Transcripts, Publications, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
8	CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	11.0	Aliases & Descriptions
9	BBS9	Bardet-Biedl syndrome 9	11.0	Publications, Aliases & Descriptions
10	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
11	TP53	tumor protein p53	11.0	Publications
12	CDK4	cyclin-dependent kinase 4	11.0	Publications, Functions
13	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
14	CHEK2	checkpoint kinase 2	11.0	Publications
15	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
16	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
17	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
18	EZR	ezrin	11.0	Publications
19	IBSP	integrin-binding sialoprotein	11.0	Publications
20	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
21	FOLR1	folate receptor 1 (adult)	11.0	Publications
22	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0	Publications
23	TWIST1	twist homolog 1 (Drosophila)	11.0	Publications
24	DHFR	dihydrofolate reductase	11.0	Publications
25	HMGA2	high mobility group AT-hook 2	11.0	Publications
26	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
27	SPP1	secreted phosphoprotein 1	11.0	Publications
28	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
29	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
30	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
31	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
32	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
33	TYMS	thymidylate synthetase	11.0	Publications
34	NKX3-2	NK3 homeobox 2	10.9	Expressions
35	RECQL4	RecQ protein-like 4	10.9	Publications
36	GDF10	growth differentiation factor 10	10.9	Publications
37	GPR15	G protein-coupled receptor 15	10.9
38	HAS2	hyaluronan synthase 2	10.9	Publications
39	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	10.9	Publications
40	TMOD4	tropomodulin 4 (muscle)	10.9	Publications
41	PTH1R	parathyroid hormone 1 receptor	10.9	Publications
42	CCL15	chemokine (C-C motif) ligand 15	10.9
43	CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	10.9	Publications
44	EDA2R	ectodysplasin A2 receptor	10.9	Publications
45	ENDOG	endonuclease G	10.9	Publications
46	FAU	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	10.9
47	ISG20	interferon stimulated exonuclease gene 20kDa	10.9	Publications
48	LBX1	ladybird homeobox 1	10.9	Publications
49	PLEKHO1	pleckstrin homology domain containing, family O member 1	10.9
50	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	10.9	Functions, Publications

Pathways related to osteosarcoma according to GeneDecks:

(show top 50)    (show all 324)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	23.1	PIK3CG, LRP5, RB1, RBL1, BRCA1, VEGFC
2	p38 Signaling36	18.4	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
3	Pancreatic Adenocarcinoma36	18.3	KIT, RB1, VEGFC, BMP1, BMP2, BMP3
4	GSK3 Signaling36	16.2	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
5	Paxillin Interactions36	15.7	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
6	Activation of PKA through GPCR36	15.5	PDE1A, PDE1C, PDE2A, PDE3A, PDE3B, KIT
7	Activation of cAMP-Dependent PKA36	15.4	PDE1A, PDE1C, PDE2A, PDE3A, PDE3B, VEGFC
8	p53 Mediated Apoptosis36	15.3	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
9	TGF-Beta Pathway36	15.3	VEGFC, BMP1, BMP2, BMP3, BMP4, BMP5
10	p70S6K Signaling36	15.1	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
11	Intracellular Calcium Signaling36	15.0	KIT, VEGFC, BMP1, BMP2, BMP3, BMP4
12	DHA Signaling36	14.8	KIT, SERPINF1, VEGFC, BMP1, BMP2, BMP3
13	Focal adhesion20	14.7	PIK3CB, PIK3CA, PIK3CG, VWF, VTN, VEGFC
14	p53 signaling pathway20	14.3	SERPINE1, BID, CHEK1, CHEK2, BAX, ATM
15	Cytokine-cytokine receptor interaction20	14.1	KIT, VEGFA, VEGFC, BMP2, BMP7, BMPR2
16	CREB Pathway36	13.9	KIT, BMP2, BMP3, BMP4, BMP5, BMP6
17	Angiogenesis3	13.5	RECK, VEGFC, MST1R, CDH5, ITGA5, ITGAV
18	Melanoma20	13.4	PIK3CB, PIK3CA, PIK3CG, RB1, CDKN1A, CDKN2A
19	Apoptosis Signaling Pathways37	13.3	BID, BIRC2, BIRC3, BIRC5, BIRC7, BCL2
20	HGF Pathway36	13.2	RB1, JUN, CDKN1B, ITGA2, ITGA4, ITGA5
21	Glioma20	13.2	PIK3CB, PIK3CA, PIK3CG, RB1, MTOR, CDKN1A
22	Prostate cancer20	13.2	PIK3CB, PIK3CA, PIK3CG, RELA, RB1, BCL2
23	Development IGF-RI signaling10	13.1	PIK3CB, PIK3CA, RELA, MYC, BCL2L1, CHUK
24	Cell cycle Regulation of G1/S transition (part 2)10	13.0	RELA, RB1, RBL2, RBL1, CHUK, JUN
25	TNF Superfamily Pathway36	13.0	CHUK, JUN, FOS, MAPK8, MAP2K2, MAPK14
26	Transcription_P53 signaling pathway41	12.9	RELA, RB1, VEGFA, BCL2, XPA, XPC
27	Immune response_Oncostatin M signaling via MAPK in human cells41	12.5	LDLR, JUN, JUNB, MMP1, MMP13, FOS
28	EGF Pathway36	12.3	MYC, CHUK, MUC1, JUN, FOS, MAPK8
29	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	12.2	RELA, MYC, BCL2, BAX, JUN, FOS
30	PGC1Alpha Pathway36	12.2	BMP1, BMP2, BMP3, BMP4, BMP5, BMP6
31	MIF Regulation of Innate Immune Cells36	12.2	BMP1, BMP2, BMP3, BMP4, BMP5, BMP6
32	NFAT Signaling and Lymphocyte Interactions36	12.2	BMP1, BMP2, BMP3, BMP4, BMP5, BMP6
33	Cytoskeleton remodeling_FAK signaling41	12.2	PIK3CB, PIK3CA, VEGFA, ITGA2, ITGB1, FN1
34	Natural killer cell mediated cytotoxicity20	12.1	PIK3CB, PIK3CA, PIK3CG, BID, ITGAL, MICB
35	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	11.9	PIK3CA, MTOR, JUN, JUNB, FOS, IRS1
36	Development Endothelin-1/EDNRA transactivation of EGFR10	11.9	PIK3CB, PIK3CA, MTOR, FOS, MAP2K2, MAPK3
37	IL-2 Pathway36	11.7	MYC, CHUK, JUN, FOS, IL2, IL2RA
38	Translation Non-genomic (rapid) action of Androgen Receptor10	11.7	RELA, IRS1, AR, MAP2K1, CAV1, ERBB2
39	Development Prolactin receptor signaling10	11.7	PIK3CB, PIK3CA, RELA, MYC, BCL2, BCL2L1
40	TRAF Pathway36	11.7	BIRC2, BIRC3, CHUK, UBC, JUN, FOS
41	MIF Mediated Glucocorticoid Regulation36	11.7	BMP1, BMP2, BMP3, BMP4, BMP5, BMP6
42	Development_VEGF-family signaling41	11.6	PIK3CB, PIK3CA, VTN, VEGFA, VEGFC, ITGA5
43	Signal transduction_PTEN pathway41	11.6	PCNA, ITGA5, ITGB1, IRS1, IGF1R, CASP9
44	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.4	BCL2, CASP9, CYCS, NTRK1, NGF
45	Cell adhesion_PLAU signaling41	11.2	PIK3CB, PIK3CA, VTN, SERPINE1, ITGB1, MET
46	Jak-STAT signaling pathway20	11.1	PIK3CB, PIK3CA, PIK3CG, MYC, BCL2L1, LEPR
47	Signal transduction AKT signaling10	11.1	PIK3CB, IRS1, IKBKB, HSP90AB1
48	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.1	MAP3K5
49	Toll-like receptor signaling pathway20	10.6	PIK3CB, PIK3CA, PIK3CG, RELA, CHUK, JUN
50	SOCS Pathway36	10.6	VEGFC, BMP1, BMP2, BMP3, BMP4, BMP5

Compounds related to osteosarcoma according to GeneDecks:

(show top 50)    (show all 469)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	38.4	LRP5, PDE1A, PDE2A, PDE3B, PDE4A, RECK
2	dexamethasone32 42 34 9 9	33.0	PIK3CA, PDE4A, SGK1, VWF, VTN, PCNA
3	atp32	28.5	PIK3CB, PIK3CA, RFC1, PDE3B, PDE4A, RECK
4	paclitaxel32 34 9 9	26.3	PIK3CA, PIK3CG, KIT, PCNA, RB1, SETD2
5	progesterone32 42 9 18 9	25.9	PIK3CA, NCOA1, PDE4A, KIT, PCNA, RB1
6	cholesterol32 9 18 9	24.6	PIK3CB, PIK3CA, LRP5, NCOA1, PDE3B, RECK
7	forskolin32 42 9 9	23.4	PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, VIM
8	12-o-tetradecanoylphorbol 13-acetate32	19.5	RB1, MYC, MYOG, MYOD1, BMP6, RARA
9	glucose32	18.3	PDE4A, KIT, SETD2, SERPINF1, VEGFC, VCAN
10	camptothecin32 42 9 9	21.0	PIK3CG, PCNA, RB1, SETD2, BRCA1, MYC
11	chloramphenicol32 9 9	19.6	SGK1, GC, SERPINC1, SETD2, SERPINE1, VIM
12	bromodeoxyuridine32	16.6	PIK3CA, PCNA, RB1, VIM, MYC, MYCN
13	imatinib32 34 9 9	19.2	PIK3CA, PIK3CG, KIT, VEGFA, MYC, BMP6
14	resveratrol32 9 18 9	19.1	PIK3CA, PIK3CG, PCNA, RB1, BRCA1, VEGFA
15	procollagen32	16.0	PCNA, VIM, BMP1, BMP2, BMP6, BGLAP
16	5-aza-2deoxycytidine32	16.0	PCNA, VIM, BRCA1, MYC, MYOD1, BMP6
17	gtp32	15.7	PIK3CA, PDE2A, PDE3B, RECK, RASGRF1, RAN
18	potassium32 9 18 9	18.3	PIK3CA, PDE3B, PDE4A, SGK1, VTN, SERPINF1
19	gf 109203x32 42	16.3	PIK3CB, PIK3CG, VEGFA, JUN, CDKN1A, CDKN3
20	sucrose32 9 18 9	17.4	RECK, MYOD1, RARA, KCNMA1, CHKA, MVP
21	histidine32	14.4	PDE3B, PDE4A, RARA, LGALS1, CHEK1, MTR
22	endotoxin32	14.1	RECK, GC, LIF, LEPR, SAA1, CD40
23	ionomycin32	13.9	PIK3CB, SETD2, RASGRF1, KCNMA1, CHUK, ATP2A3
24	dihydrofolate32	13.7	RB1, RBL1, MYBL2, MTHFR, MTR, CDK2
25	valine32	13.5	LRP5, KIT, VIM, LPL, MTHFR, MTR
26	17-(allylamino)-17-demethoxygeldanamycin32	13.4	KIT, SETD2, BIRC5, CHEK1, CHEK2, CDKN1A
27	cgmp32	13.3	PDE1A, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A
28	titanium32	13.2	VTN, VIM, BMP2, BMP4, BMP7, BGLAP
29	troglitazone32 42 9 9	16.2	PIK3CG, RB1, SERPINE1, LPL, VDR, BMP6
30	alendronate32 9 9	15.2	VDR, BMP2, BGLAP, CD36, MMP1, MMP13
31	prostacyclin32	13.1	PDE2A, PDE3B, PDE4A, VWF, VTN, SERPINC1
32	morphine32 9 9	15.0	CNR1, YY1, JUNB, MIF, IL1RN, MAPK10
33	prostaglandin f2alpha32	12.9	PDE4A, SERPINE1, LPL, CD44, MMP1, IL1A
34	sodium dodecylsulfate32	12.8	VWF, VTN, SERPINE1, LPL, MYC, BMP6
35	silymarin32	12.8	PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
36	pdtc32	12.6	PIK3CA, PIK3CG, SETD2, BIRC3, BIRC5, PARP1
37	bisindolylmaleimide32	12.4	PIK3CB, S100B, CFLAR, ITGA2, FOS, MAPK3
38	progestins32	12.4	LIF, S100A6, MKI67, AR, IL18R1, FASN
39	simvastatin32 34 42 9 18 9	17.2	VWF, SERPINE1, VEGFA, LPL, BMP2, BMP6
40	pd15303532	12.1	PIK3CG, VEGFA, BIRC5, JUN, MMP1, MAPK8
41	trastuzumab32 34 9 9	15.1	PIK3CA, PIK3CG, KIT, VEGFC, BIRC5, MUC1
42	pioglitazone32 9 9	13.7	NCOA1, VEGFA, LPL, RARA, JUN, CD40
43	atorvastatin32 34 9 18 9	15.4	VWF, VEGFA, LPL, BMP2, BMP6, CHKA
44	staurosporin32	11.3	PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, CDKN3
45	ns 39832 42	12.2	PIK3CG, PCNA, BGLAP, PARP1, CDKN1B, MMP1
46	piceatannol32 42 9 9	14.2	PIK3CG, CHUK, MAPK8, MAPK3, MAPK14, CCNA2
47	s-nitroso-n-acetylpenicillamine32	11.2	PARP1, FN1, IL1B, IL8, ANXA5, MAPK14
48	ivig32	11.1	VWF, IL18R1, IL3, FASLG, CCR5, IFNB1
49	polyinosinic-polycytidylic acid32	9.3	CD40, IL10, IL15, IL18, IL2, IL6
50	il 1032	8.6	VDR, BMP6, LIF, CD8A, CD40, IL10

Cellular components related to osteosarcoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	33.1	ZNF395, PIK3CB, KLF10, PDE2A, PDE4A, PDE4B
2	cytoplasm	GO:005737	27.1	ZNF395, PIK3CG, PDE2A, RECQL4, RELA, KIT
3	plasma membrane	GO:005886	24.2	PIK3CG, LRP5, PDE2A, RECK, SGK1, CNR1
4	cytosol	GO:005829	23.7	PIK3CB, PIK3CA, PIK3CG, PDE1A, PDE1C, PDE2A
5	nucleoplasm	GO:005654	20.0	RFC1, NCOA1, RELA, PCNA, RB1, RBL2
6	extracellular region	GO:005576	19.3	VWF, VTN, GC, SERPINC1, SERPINF1, SERPINE1
7	extracellular space	GO:005615	18.8	KIT, VTN, GC, SERPINC1, SERPINF1, SERPINE1
8	integral to plasma membrane	GO:005887	18.6	CNR1, LPAR1, LPAR3, BMPR2, BDKRB1, BDKRB2
9	cell surface	GO:009986	15.2	VEGFA, LPAR1, LPL, BMP2, BMPR2, RARA
10	perinuclear region of cytoplasm	GO:048471	13.3	PDE2A, PDE4A, PDE4B, GC, CLU, MTDH
11	proteinaceous extracellular matrix	GO:005578	12.8	VWF, VEGFA, VCAN, BMP4, LGALS1, MMP1
12	external side of plasma membrane	GO:009897	12.3	KIT, VWF, LDLR, B2M, CD36, CD8A
13	extracellular matrix	GO:031012	12.0	VWF, VTN, SERPINF1, SERPINE1, LPL, VCAN
14	platelet alpha granule lumen	GO:031093	11.2	VWF, SERPINE1, VEGFA, VEGFC, CLU, FN1

Biological processes related to osteosarcoma according to GeneDecks:

(show top 50)    (show all 83)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	18.9	PIK3CB, PDE1A, PDE1C, PDE4A, PDE4B, PDE4C
2	positive regulation of cell proliferation	GO:008284	16.5	LRP5, KIT, VEGFA, VEGFC, MYC, RARA
3	negative regulation of transcription from RNA polymerase II promoter	GO:000122	15.7	KLF10, PDE2A, VDR, MYC, BMI1, BMP2
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	15.6	LRP5, NCOA1, RELA, RB1, RBL1, SERPINE1
5	negative regulation of cell proliferation	GO:008285	15.5	KLF10, VDR, BMP2, BMP4, BMP5, LIF
6	virus-host interaction	GO:019048	15.5	RELA, RB1, RBL1, VIM, NACA, RAN
7	mitotic cell cycle	GO:000278	15.4	RFC1, KIF2B, KIF2A, PCNA, BUB3, RB1
8	apoptotic process	GO:006915	15.3	SGK1, VIM, BRCA1, RASGRF1, BLCAP, BID
9	positive regulation of transcription, DNA-dependent	GO:045893	15.0	LRP5, NCOA1, RELA, RB1, BRCA1, MYC
10	response to drug	GO:042493	14.7	PDE3A, PDE4A, VEGFC, LPL, MYC, BGLAP
11	skeletal system development	GO:001501	14.6	KLF10, VDR, BMP1, BMP2, BMP3, BMP5
12	negative regulation of apoptotic process	GO:043066	14.6	PIK3CG, PDE3A, RELA, RB1CC1, SERPINE1, VEGFA
13	positive regulation of cell migration	GO:030335	14.3	VEGFA, BMP2, CDH13, ITGAV, ITGB1, MMP14
14	blood coagulation	GO:007596	14.0	PIK3CB, PIK3CA, PIK3CG, PDE1A, PDE2A, PDE3A
15	ossification	GO:001503	13.7	MYOG, BMP1, BMP3, BMP5, BMP7, BCL2
16	negative regulation of transcription, DNA-dependent	GO:045892	13.7	RELA, RB1, BRCA1, VDR, BMP2, BMP4
17	response to DNA damage stimulus	GO:006974	13.7	SGK1, BRCA1, VCP, MYC, RASSF1, PARP4
18	G1/S transition of mitotic cell cycle	GO:000082	13.7	PCNA, RB1, BCL2, UBC, CDKN1A, CDKN2C
19	heart development	GO:007507	13.7	PCNA, RB1CC1, VCAN, BMP2, ATM, ITGA4
20	response to organic cyclic compound	GO:014070	13.6	BMP4, JUN, JUNB, CDKN1A, CDK1, FOSL1
21	response to lipopolysaccharide	GO:032496	13.6	CNR1, BDKRB1, JUN, MMP9, IL12A, IL1A
22	cell-cell signaling	GO:007267	13.5	KLF10, BMP2, BMP3, CGB, AR, FGFR2
23	response to hypoxia	GO:001666	13.2	VEGFA, BMP2, USF1, BCL2, SDC2, KCNMA1
24	aging	GO:007568	13.1	CNR1, SERPINF1, VDR, P2RY1, JUN, IL15
25	positive regulation of apoptotic process	GO:043065	13.1	NCOA1, CNR1, LPAR1, BMP2, BMP4, BID
26	cell cycle arrest	GO:007050	13.0	RB1, MYC, RASSF1, SART1, ATM, CDKN1A
27	response to estradiol stimulus	GO:032355	12.8	NCOA1, GC, VDR, BMP4, RARA, BID
28	response to wounding	GO:009611	12.5	VWF, ITGB4, FN1, MET, GRIN2C, CCR1
29	cell surface receptor signaling pathway	GO:007166	12.5	BIRC2, BIRC3, BDKRB2, LEPR, P2RY1, CD36
30	positive regulation of endothelial cell proliferation	GO:001938	12.5	VEGFA, BMP2, BMP4, BMP6, BMPR2, MTOR
31	angiogenesis	GO:001525	12.5	PIK3CA, PIK3CG, PDE3B, SETD2, SERPINE1, VEGFA
32	response to ethanol	GO:045471	12.4	CNR1, BGLAP, BCL2, CDK1, MMP9, MGMT
33	response to mechanical stimulus	GO:009612	12.4	BMP2, BMP4, BGLAP, P2RY1, JUN, JUNB
34	positive regulation of MAPK cascade	GO:043410	12.4	KIT, LPAR1, LPAR3, LIF, CD36, CDH2
35	positive regulation of protein phosphorylation	GO:001934	12.3	RB1CC1, VEGFA, BMP2, BMP4, MTOR, P2RY1
36	platelet activation	GO:030168	12.3	PIK3CB, PIK3CA, PIK3CG, VWF, SERPINE1, VEGFA
37	inflammatory response	GO:006954	12.3	PIK3CG, RELA, KIT, BMP2, BMP6, PARP4
38	phosphatidylinositol-mediated signaling	GO:048015	12.2	PIK3CB, PIK3CA, PCNA, CHUK, MTOR, CDKN1B
39	nerve growth factor receptor signaling pathway	GO:048011	12.2	PIK3CB, PIK3CA, PDE1A, PDE1C, RELA, RASGRF1
40	osteoblast differentiation	GO:001649	12.1	BMP4, BGLAP, JUNB, FHL2, IL18, CCL3
41	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.0	BMP2, BMP4, P2RY1, CD44, FLT4, MIF
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.0	VTN, VEGFA, LIF, MTOR, CD36, CD4
43	platelet degranulation	GO:002576	12.0	VWF, SERPINE1, VEGFA, VEGFC, CLU, CD36
44	cellular response to mechanical stimulus	GO:071260	11.9	PDE2A, CHEK1, CD40, ITGB1, IL18, IL1B
45	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	11.9	RELA, LPAR1, BIRC2, BIRC3, LGALS1, CHUK
46	epidermal growth factor receptor signaling pathway	GO:007173	11.7	PIK3CA, PDE1A, PDE1C, CHUK, UBC, MTOR
47	anti-apoptosis	GO:006916	11.4	PIK3CA, RELA, BIRC2, BIRC3, BIRC5, BIRC7
48	positive regulation of protein kinase B signaling cascade	GO:051897	11.3	PIK3CG, MTDH, MTOR, MST1R, CCL3, CCR7
49	positive regulation of smooth muscle cell proliferation	GO:048661	11.2	BMP4, JUN, CDH13, IL6, IL6R, IGF1
50	response to glucocorticoid stimulus	GO:051384	10.5	SERPINF1, SERPINE1, BGLAP, IL10, IL1B, IL1RN

Molecular functions related to osteosarcoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	39.8	GADD45A, EFNA1, WEE1, WNT1, WRN, SIX1
2	protein homodimerization activity	GO:042803	16.5	GGCT, WRN, PGF, NPM1, CSF1R, CSF1
3	sequence-specific DNA binding transcription factor activity	GO:003700	16.4	EGR1, ELF1, ELK1, HES1, HEY2, HIF1A
4	protein heterodimerization activity	GO:046982	14.6	ERBB2, P2RY1, BAX, BCL2L1, BCL2, BDKRB2
5	transcription factor binding	GO:008134	13.8	STAT3, TWIST1, HIF1A, HEY2, HES1, CTNNB1
6	protein kinase binding	GO:019901	13.8	PTEN, TP73, TP53, GHR, HSPB1, IKBKB
7	identical protein binding	GO:042802	12.8	GRIN3A, RASSF1, VCP, VIM, PCNA, RELA
8	growth factor activity	GO:008083	12.7	TGFB2, TGFB1, HBEGF, EGF, PDGFB, PDGFA
9	enzyme binding	GO:019899	12.4	CASP2, BIRC7, BIRC5, USF1, RARA, BRCA1
10	receptor binding	GO:005102	12.3	LTA, PDGFRB, NOS2, CRAT, PPP2R4, SRC
11	heparin binding	GO:008201	12.3	ADAMTS1, PTPRC, PTN, CCL2, CCL7, CCL15
12	cytokine activity	GO:005125	11.6	IL1A, BMP7, BMP6, BMP5, BMP4, BMP3
13	transcription regulatory region DNA binding	GO:044212	11.1	HIF1A, NFKB1, PHB, RXRA, SMAD6, SMAD4