MCID: OST018
MIFTS: 79

Osteosarcoma malady

Rare diseases, Bone diseases, Cancer diseases categories

Summaries for Osteosarcoma

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44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. the average age at diagnosis is 15. boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. in rare cases, osteosarcoma occurs in adults. the cause of osteosarcoma is not known. in some cases, it runs in families, and at least one gene has been linked to increased risk. although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone.a number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal. treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery. last updated: 6/7/2009

MalaCards: Osteosarcoma, also known as osteogenic sarcoma, is related to chondroblastic osteosarcoma and sarcoma. An important gene associated with Osteosarcoma is TP53 (tumor protein p53), and among its related pathways are DNA damage DNA damage induced responses and PLK3 signaling events. The drugs cisplatin and cisplatin pwdr and the compounds pt 430 and metoprine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Wikipedia:66 Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal... more...

Description from OMIM:48 259500

Aliases & Classifications for Osteosarcoma

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Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 60SNOMED-CT via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

50
osteosarcoma:
Prevalence: 1-9/100000; Age of onset: Childhood


Aliases & Descriptions:

osteosarcoma 9 10 44 48 11 46 50 63
osteogenic sarcoma 9 44 50
osteosarcoma - disorder 9 23
osteosarcoma, no icd-o subtype 9
neoplasms, bone tissue 63
bone tissue neoplasm 9
skeletal sarcoma 9
osteoid sarcoma 9


External Ids:

Disease Ontology9 DOID:3347
MeSH36 D012516
OMIM48 259500
NCIt41 C9145
SNOMED-CT via Orphanet60 307576001, 21708004
MESH via Orphanet37 D012516
ICD10 via Orphanet27 C40, C41
UMLS via Orphanet64 C0029463

Related Diseases for Osteosarcoma

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Osteosarcoma family:

Localized Osteosarcoma

Diseases related to Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1chondroblastic osteosarcoma31.2BGLAP
2sarcoma31.0CD99, MDM2, RB1, TWIST1, FOLR1, DHFR
3retinoblastoma30.9TP53, CHEK2, DHFR, FOS, RB1, MDM2
4fibrous dysplasia30.7BGLAP, FOS
5paget's disease of bone30.6TNFRSF11A
6rhabdomyosarcoma30.6EZR, TP53, RB1, MDM2, CD99
7fibrosarcoma30.5MDM2, FOS, DHFR
8liposarcoma30.4TP53, TSPAN31, RB1, MDM2
9breast cancer30.4EZR, TP53, CHEK2, DHFR, FOS, TWIST1
10li-fraumeni syndrome30.4TP53, CHEK2, RB1, MDM2
11giant cell tumor30.3TNFRSF11A, BGLAP
12osteosarcoma, somatic30.3RB1, CHEK2
13leiomyosarcoma30.3MDM2, RB1, TP53
14leukemia30.3TP53, CHEK2, DHFR, FOLR1, FOS, RB1
15meningioma30.2EZR
16transitional cell carcinoma30.1MDM2, RB1, TP53
17colon cancer30.1TP53, CHEK2, DHFR, FOS
18adenocarcinoma30.1MDM2, RB1, FOLR1, CHEK2, TP53, EZR
19melanoma30.1EZR, TP53, CHEK2, DHFR, RB1, MDM2
20osteofibrous dysplasia29.9BGLAP
21alveolar rhabdomyosarcoma29.9RB1, MDM2
22prostate cancer29.9RB1, FOS, CHEK2, EZR, BGLAP
23ataxia telangiectasia29.9TP53, CHEK2, DHFR, MDM2
24astrocytoma29.9EZR, TP53, FOS, RB1, MDM2
25bone carcinoma29.9BGLAP, TNFRSF11A, EZR, RB1, MDM2
26cervical cancer29.9MDM2, RB1, TP53
27lung cancer29.9TP53, CHEK2, DHFR, FOS, RB1, MDM2
28hepatocellular carcinoma29.9EZR, TP53, FOS, TWIST1, RB1, MDM2
29pediatric osteosarcoma10.7
30multifocal osteogenic sarcoma10.6
31chondrosarcoma10.5
32extraosseous osteosarcoma10.5
33localized osteosarcoma10.5
34osteoblastoma10.5
35juxtacortical osteosarcoma10.5
36endotheliitis10.4
37fibrous histiocytoma10.4
38histiocytoma10.4
39rothmund-thomson syndrome10.4
40bone osteosarcoma10.4
41osteochondroma10.3
42malignant fibrous histiocytoma of bone10.3
43hypoxia10.3
44diamond-blackfan anemia10.3
45synchronous multifocal osteogenic sarcoma10.3
46asynchronous multifocal osteogenic sarcoma10.3
47childhood parosteal osteogenic sarcoma10.3
48breast osteosarcoma10.3
49myositis ossificans10.3
50myositis10.3

Graphical network of the top 20 diseases related to Osteosarcoma:



Diseases related to osteosarcoma

Symptoms for Osteosarcoma

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Sources:
48OMIM
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Clinical features from OMIM:

259500

Drugs & Therapeutics for Osteosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Osteosarcoma

Search NIH Clinical Center for Osteosarcoma

Search CenterWatch for Osteosarcoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Osteosarcoma

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Sources:
23GTR
See all sources

Genetic tests related to Osteosarcoma:

id Genetic test Affiliating Genes
1 Osteosarcoma23

Anatomical Context for Osteosarcoma

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34MalaCards
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MalaCards organs/tissues related to Osteosarcoma:

34
Bone, Lung, Breast, Endothelial, Liver, Thyroid, Prostate, Colon, Kidney, Monocytes, T cells, Ovary, Smooth muscle, Nk cells, Bone marrow, Lymph node, Small intestine, Heart, Spinal cord, Cervix, Testes, Pancreas, Uterus, Brain, Adrenal gland, Skin

Animal Models for Osteosarcoma or affiliated genes

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38MGI
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Publications for Osteosarcoma

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53PubMed
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Articles related to Osteosarcoma:

(show top 50)    (show all 2106)
idTitleAuthorsYear
1
Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. (24247158)
2014
2
MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell. (23740615)
2013
3
Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. (24129234)
2013
4
p38 MAPK regulates the expression of ether A go-go potassium channel in human osteosarcoma cells. (23450231)
2013
5
MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects. (23797816)
2013
6
Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia. (24147271)
2013
7
Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. (23708932)
2013
8
Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. (21890444)
2012
9
A case of parosteal osteosarcoma with a rare complication of myositis ossificans. (23194024)
2012
10
Effect of C23 down-regulation on proliferation inhibition and apoptosis induced by cisplatin in human osteosarcoma SaOS-2 cells]. (22349377)
2012
11
TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. (22021909)
2012
12
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. (22659570)
2012
13
WEE1 inhibition sensitizes osteosarcoma to radiotherapy. (21529352)
2011
14
Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX. (21310198)
2011
15
miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. (22093834)
2011
16
Expression change of ezrin as a prognostic factor in primary osteosarcoma. (20859706)
2011
17
Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. (19896763)
2010
18
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. (20399482)
2010
19
Expression of heat shock proteins in osteosarcomas. (20632817)
2010
20
Interleukin 24 inhibits growth and induces apoptosis of osteosarcoma cells MG-63 in vitro and in vivo]. (20112699)
2009
21
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. (19441093)
2009
22
Down-regulation of ribosomal protein L7A in human osteosarcoma. (19125294)
2009
23
Small cell extraskeletal osteosarcoma. (19309043)
2009
24
Radiosensitivity of canine osteosarcoma cells transfected with wild-type p53 in vitro. (19178679)
2008
25
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases. (18298897)
2008
26
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. (18559481)
2008
27
TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. (17483704)
2007
28
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. (17279585)
2007
29
Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. (17684144)
2007
30
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. (17465200)
2007
31
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. (17471233)
2007
32
The retinoblastoma protein in osteoblast differentiation and osteosarcoma. (17100605)
2006
33
Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? (16786118)
2006
34
Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. (15946696)
2005
35
Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. (15796961)
2005
36
Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. (16380506)
2005
37
Rothmund-Thomson syndrome, Klippel-Feil syndrome, and osteosarcoma. (15197508)
2004
38
Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. (12802802)
2003
39
Intradural primary chondroblastic osteosarcoma: case report. (11733332)
2001
40
Isolation, identification and biological activity of 24R,25-dihydroxy-3-epi-vitamin D3: a novel metabolite of 24R,25-dihydroxyvitamin D3 produced in rat osteosarcoma cells (UMR 106). (11508700)
2001
41
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
42
Hormones, autocrine and paracrine regulators of tumor growth in osteosarcoma]. (11383452)
2001
43
Phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cells. (11018472)
2000
44
Chondroblastoma-like osteosarcoma. (10192265)
1999
45
Comparative genomic hybridization of low-grade central osteosarcoma. (9619593)
1998
46
Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. (9404699)
1997
47
Relationship between the induction of heat shock proteins and the decrease in glucocorticoid receptor during heat shock response in human osteosarcoma cells. (8745575)
1995
48
Transforming growth factor-beta modulates eicosanoid metabolism in osteogenic osteosarcoma cells. (1908241)
1991
49
Case report 641: Chondroblastoma-like osteosarcoma. (2278017)
1990
50
Osteosarcoma in a boy with Rothmund-Thomson syndrome. (6932639)
1980

Variations for Osteosarcoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Osteosarcoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.722C> T (p.Ser241Phe)single nucleotide variantLikely pathogenic, Pathogenicrs28934573GRCh37Chr 17, 7577559: 7577559
2TP53TP53, 7-BP INS, NT13160insertionPathogenic
3CHEK2NM_007194.3(CHEK2): c.254C> T (p.Pro85Leu)single nucleotide variantBenign, Likely benign, Pathogenicrs17883862GRCh37Chr 22, 29130456: 29130456
4CHEK2NM_007194.3(CHEK2): c.49G> T (p.Ala17Ser)single nucleotide variantPathogenicrs137853008GRCh37Chr 22, 29130661: 29130661

Expression for genes affiliated with Osteosarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteosarcoma

Search GEO for disease gene expression data for Osteosarcoma.

Pathways for genes affiliated with Osteosarcoma

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 54QIAGEN, 58SinoBiological, 62Tocris Bioscience, 31KEGG, 5Cell Signaling Technology
See all sources

Pathways related to Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CHEK2, TP53
210.3CHEK2, TP53
310.3TP53, OS9
4
Show member pathways
10.3MDM2, TP53
5
Show member pathways
10.2SLC19A1, FOLR1
6
Show member pathways
10.2RB1, CHEK2, TP53
7
Show member pathways
10.2RB1, FOS, TP53
810.2TP53, FOS, RB1
910.2CHEK2, FOS, RB1
10
Show member pathways
DNA damage Role of SUMO in p53 regulation61
10.2TP53, CHEK2, MDM2
11
Show member pathways
ATM Signaling Pathway39
10.2MDM2, CHEK2, TP53
1210.2TP53, CHEK2, MDM2
13
Show member pathways
p53 pathway39
10.2TP53, CHEK2, MDM2
14
Show member pathways
10.2MDM2, CHEK2, TP53
1510.2TP53, FOS, MDM2
16
Show member pathways
Signal transduction PTEN pathway61
10.2TP53, FOS, MDM2
17
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
10.2TP53, FOS, MDM2
18
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
10.2MDM2, FOS, TP53
1910.2TP53, RB1, MDM2
20
Show member pathways
10.2TP53, RB1, MDM2
2110.2TP53, RB1, MDM2
2210.2MDM2, RB1, TP53
2310.2MDM2, RB1, TP53
24
Show member pathways
10.2MDM2, RB1, FOS
2510.1BGLAP, RB1, MDM2
2610.1BGLAP, TNFRSF11A, FOS
2710.1BGLAP, TWIST1, RB1
28
Show member pathways
Immune response MIF in innate immunity response61
10.1TP53, FOS, FOSB
29
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
10.1TP53, FOS, FOSB
3010.1FOSB, FOS, TNFRSF11A
3110.1TP53, CHEK2, FOS, RB1
3210.1TP53, CHEK2, RB1, MDM2
33
Show member pathways
DNA damage response39
10.1TP53, CHEK2, RB1, MDM2
34
Show member pathways
Cell cycle39
10.1TP53, CHEK2, RB1, MDM2
35
Show member pathways
10.1MDM2, RB1, CHEK2, TP53
3610.1MDM2, RB1, FOS, TP53
3710.1MDM2, RB1, FOS, TP53
38
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
10.1TNFRSF11A, TP53, FOS, RB1
3910.1BGLAP, TP53, FOS, MDM2
40
Show member pathways
10.0TP53, DHFR, RB1, MDM2
4110.0TP53, DHFR, RB1, MDM2
4210.0TP53, FOS, FOSB, RB1
4310.0MDM2, TWIST1, TP53, EZR
44
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
10.0TP53, CHEK2, FOS, RB1, MDM2
45
Show member pathways
10.0TP53, CHEK2, FOS, RB1, MDM2
46
Show member pathways
10.0TP53, CHEK2, FOS, RB1, MDM2
47
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.9TP53, CHEK2, XRN1, RB1, MDM2
48
Show member pathways
9.8BGLAP, TP53, CHEK2, DHFR, RB1, MDM2
49
Show member pathways
9.8MDM2, RB1, FOSB, FOS, CHEK2, TP53
50
Show member pathways
9.7TNFRSF11A, TP53, CHEK2, FOS, FOSB, RB1

Compounds for genes affiliated with Osteosarcoma

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1pt 4304610.6SLC19A1, DHFR
2metoprine4610.6SLC19A1, DHFR
3bpde4610.6TP53, MDM2, CHEK2
4pt5234610.6DHFR, SLC19A1
5ag 3314610.6DHFR, SLC19A1
6ag 3374610.5DHFR, SLC19A1
7trimetrexate46 1211.5DHFR, FOLR1, SLC19A1
8aflatoxin b146 2511.5RB1, MDM2, TP53
9folic acid52 25 1212.5DHFR, FOLR1, SLC19A1
10aphidicolin4610.5CHEK2, RB1, DHFR, TP53
11n-hydroxysuccinimide4610.5FOLR1, SLC19A1
12ag 20344610.5DHFR, SLC19A1
13tomudex4610.5FOLR1, SLC19A1, DHFR, TP53
14carboplatin46 52 1212.4TP53, RB1, MDM2, SLC19A1
15dihydrofolate4610.4SLC19A1, RB1, DHFR, FOLR1
16vincristine46 52 1212.4MDM2, RB1, TP53, SLC19A1
17camptothecin46 62 1212.4MDM2, TP53, CHEK2, RB1
18adriamycin4610.4TP53, CHEK2, DHFR, RB1, MDM2
19mitomycin c4610.4TP53, DHFR, RB1, MDM2, BGLAP
20hdmtx4610.3SLC19A1, DHFR
21cyclophosphamide46 52 1212.3MDM2, DHFR, TP53, RB1
22etoposide46 52 62 1213.3DHFR, MDM2, CHEK2, TP53, RB1
235-aza-2deoxycytidine4610.3SLC19A1, MDM2, FOLR1, TP53
24leucovorin46 52 1212.3SLC19A1, FOLR1, DHFR
25arsenite46 2511.3DHFR, TP53, FOS, MDM2
265fluorouracil4610.3DHFR, MDM2, SLC19A1, TP53, RB1
27roscovitine4610.3MDM2, RB1, TP53
28geneticin4610.3FOS, DHFR
29methotrexate52 46 1212.3FOLR1, MDM2, RB1, DHFR, SLC19A1
30calcitriol46 62 25 1213.3RB1, BGLAP, TNFRSF11A, FOS
31ly2940024610.3MDM2, RB1, TP53, EZR, FOS
32lometrexol4610.2SLC19A1, FOLR1
33genistein46 30 62 3 25 1215.2FOS, CHEK2, RB1, MDM2, EZR
34h2o24610.2DHFR, TP53, FOS, BGLAP, RB1, MDM2
35okadaic acid46 6211.2RB1, FOSB, FOS, CHEK2
36benzo(a)pyrene4610.2MDM2, RB1, TP53
37paraffin4610.2EZR, BGLAP, TP53, RB1, CD99, MDM2
38thymidylate4610.2DHFR, SLC19A1, MDM2, RB1, FOS, FOLR1
39doxorubicin46 52 1212.2FOLR1, TP53, CHEK2, MDM2, SLC19A1, RB1
401843u894610.1DHFR, SLC19A1
41paclitaxel46 52 1212.1TP53, SLC19A1, MDM2, RB1, TWIST1, FOLR1
42oligonucleotide4610.1RB1, TP53, CHEK2, FOLR1, FOS, FOSB
43vegf4610.1BGLAP, TNFRSF11A, TP53, FOS, RB1, MDM2
44phosphatidylinositol4610.1RB1, TNFRSF11A, EZR, FOLR1, MDM2, CHEK2
45cisplatin46 52 62 1213.0BGLAP, MDM2, SLC19A1, TP53, CHEK2, DHFR
46alanine4610.0MDM2, SLC19A1, BGLAP, DHFR, EZR, CHEK2
47n-phosphonacetyl-l-aspartate4610.0DHFR, TP53
48estrogen469.8TNFRSF11A, TWIST1, EZR, DHFR, BGLAP, FOS
49tyrosine469.7TNFRSF11A, RB1, MDM2, CHEK2, FOS, AKAP12
50serine469.5MDM2, SLC19A1, TP53, RB1, FOSB, FOS

GO Terms for genes affiliated with Osteosarcoma

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Sources:
17Gene Ontology
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Cellular components related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:01660510.2RB1, CHEK2, TP53
2nucleoplasmGO:0056549.5CTDSP2, MDM2, RB1, FOS, CHEK2, TP53

Biological processes related to Osteosarcoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to gravityGO:00962910.5FOS, BGLAP
2folic acid transportGO:01588410.5SLC19A1, FOLR1
3replicative senescenceGO:09039910.5TP53, CHEK2
4folic acid metabolic processGO:04665510.5SLC19A1, FOLR1
5regulation of protein catabolic processGO:04217610.4MDM2, CHEK2
6negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.4TWIST1, MDM2
7response to mechanical stimulusGO:00961210.4FOSB, FOS, BGLAP
8cellular response to hypoxiaGO:07145610.4TP53, TWIST1, MDM2
9regulation of bone mineralizationGO:03050010.4BGLAP, TWIST1
10response to drugGO:04249310.2MDM2, FOSB, FOS, BGLAP
11response to corticosteroneGO:05141210.2FOS, FOSB
12positive regulation of gene expressionGO:01062810.1MDM2, TWIST1, EZR
13response to morphineGO:04327810.1MDM2, FOSB
14positive regulation of transcription, DNA-templatedGO:04589310.1RB1, FOS, CHEK2, TP53
15cell agingGO:00756910.0TP53, BGLAP

Molecular functions related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:00851710.1SLC19A1, FOLR1
2ubiquitin protein ligase bindingGO:03162510.1TP53, CHEK2, RB1, MDM2
3identical protein bindingGO:04280210.1MDM2, RB1, CHEK2, TP53
4transcription factor bindingGO:00813410.0RB1, TWIST1, FOSB, FOS, TP53
5folic acid bindingGO:0055429.9FOLR1, SLC19A1
6protein bindingGO:0055159.0CHEK2, TP53, OS9, EZR, TNFRSF11A, AKAP12

Products for genes affiliated with Osteosarcoma

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  • Antibodies
  • Proteins
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Sources for Osteosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet