MCID: OST018
MIFTS: 70

Osteosarcoma malady

Bone, Cancer categories

Summaries for Osteosarcoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Osteosarcoma is the most common cancerous (malignant) bone tumor in youth. the average age at diagnosis is 15. boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. in rare cases, osteosarcoma occurs in adults. the cause of osteosarcoma is not known. in some cases, it runs in families, and at least one gene has been linked to increased risk. although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone.a number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal. treatment usually starts after a biopsy of the tumor and includes chemotherapy followed by surgery. last updated: 6/7/2009

MalaCards: Osteosarcoma, also known as osteogenic sarcoma, is related to chondroblastic osteosarcoma and fibrous dysplasia. An important gene associated with Osteosarcoma is TP53 (tumor protein p53), and among its related pathways are Rho Family GTPases and Prostate Cancer. The drugs cisplatin and methotrexate and the compounds tyrosine and cisplatin have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and growth/size.

Wikipedia:64 Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal... more...

Description from OMIM:47 259500

Aliases & Classifications for Osteosarcoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
osteosarcoma:
Prevalence: 1-9/100000; Age of onset: Childhood


Aliases & Descriptions:

osteosarcoma 8 9 43 47 10 45 49 61
osteogenic sarcoma 8 43 49
osteosarcoma - disorder 8 22
osteosarcoma, no icd-o subtype 8
neoplasms, bone tissue 61
bone tissue neoplasm 8
skeletal sarcoma 8
osteoid sarcoma 8


External Ids:

Disease Ontology8 DOID:3347
MeSH35 D012516
NCIt40 C9145
OMIM47 259500
MESH via Orphanet36 D012516
ICD10 via Orphanet26 C40, C41
SNOMED-CT via Orphanet58 21708004
UMLS via Orphanet62 C0029463

Related Diseases for Osteosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Osteosarcoma family:

localized osteosarcoma

Diseases related to Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1chondroblastic osteosarcoma31.0BGLAP
2fibrous dysplasia30.5FOS, BGLAP
3squamous cell carcinoma30.1TP53, FOLR1, FOS, MDM2, RB1, CHEK2
4adenocarcinoma30.0RB1, CDK4, CHEK2, EZR, TP53, FOLR1
5li-fraumeni syndrome30.0MDM2, CHEK2, TP53, RB1
6adenoma29.9CDK4, RB1, TP53
7bladder carcinoma29.9TP53, MDM2, RB1
8transitional cell carcinoma29.9RB1, TP53, MDM2
9gliosarcoma29.9CDK4
10astrocytoma29.7CDK4, RB1, FOS, MDM2, TP53, EZR
11bone carcinoma29.7BGLAP, RB1, EZR, MDM2, TNFRSF11A
12alveolar rhabdomyosarcoma29.7MDM2, CDK4, RB1
13synovial sarcoma29.7CD99
14thyroid cancer29.7BGLAP, TP53
15osteofibrous dysplasia29.7BGLAP
16bone osteosarcoma10.9
17localized osteosarcoma10.5
18breast osteosarcoma10.5
19osteoblastoma10.5
20fibrous histiocytoma10.4
21rothmund-thomson syndrome10.4
22osteochondroma10.3
23hypoxia10.3
24asynchronous multifocal osteogenic sarcoma10.2
25synchronous multifocal osteogenic sarcoma10.2
26diamond-blackfan anemia10.2
27bone giant cell sarcoma10.2
28childhood parosteal osteogenic sarcoma10.2
29myositis ossificans10.2
30bilateral retinoblastoma10.2
31fibrosarcomatous osteosarcoma10.2
32chondroblastoma10.1
33mccune albright syndrome10.1
34childhood extraosseous osteosarcoma10.1
35ossifying fibroma10.1
36small cell osteogenic sarcoma10.1
37werner syndrome10.1
38adult extraosseous osteosarcoma10.1
39acute leukemia10.1
40mccune–albright syndrome10.1
41chromophobe renal cell carcinoma10.1
42oslam syndrome10.1
43osteosarcoma, somatic10.1
44burn scar10.1
45middle lobe syndrome10.1
46friedreich ataxia10.1
47priapism10.1
48fibrodysplasia ossificans progressiva10.1
49epidermolysis bullosa dystrophica10.1
50papillary carcinoma10.1

Graphical network of the top 20 diseases related to Osteosarcoma:



Diseases related to osteosarcoma

Clinical Features for Osteosarcoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

259500

Drugs & Therapeutics for Osteosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Osteosarcoma

Search NIH Clinical Center for Osteosarcoma

Search CenterWatch for Osteosarcoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Osteosarcoma

Sources:
22GTR
See all sources

Genetic tests related to Osteosarcoma:

id Genetic test Affiliating Genes
1 Osteosarcoma22

Anatomical Context for Osteosarcoma

Animal Models for Osteosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Osteosarcoma

Sources:
51PubMed
See all sources

Articles related to Osteosarcoma:

(show top 50)    (show all 2155)
idTitleAuthorsYear
1
Prognostic Factors in Elderly Osteosarcoma Patients: A Multi-institutional Retrospective Study of 86 Cases. (23975321)
2014
2
p38 MAPK regulates the expression of ether A go-go potassium channel in human osteosarcoma cells. (23450231)
2013
3
Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. (23142238)
2013
4
CD44: evidence for its role in osteosarcoma morbidity and mortality. (24422065)
2013
5
Extraskeletal Osteosarcoma: A case report and review of the literature. (24421944)
2013
6
Association of the vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphisms with osteosarcoma susceptibility in a Chinese population. (24310504)
2013
7
A case of intradural osteosarcoma of the spine. (23578988)
2013
8
Neurofibromatosis type 1, gastrointestinal stromal tumor, leiomyosarcoma and osteosarcoma: four cases of rare tumors and a review of the literature. (23218951)
2013
9
Osteosarcoma: review of the various types with emphasis on recent advancements in imaging. (23673544)
2013
10
Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity. (24334332)
2013
11
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma. (22652833)
2012
12
HMGB1 promotes drug resistance in osteosarcoma. (22102692)
2012
13
Osteosarcoma following growth hormone therapy in recurrent acute lymphoblastic leukemia and Rapadilino syndrome. (22475304)
2012
14
MicroRNA-21 is involved in osteosarcoma cell invasion and migration. (20480266)
2011
15
The kinase Mirk is a potential therapeutic target in osteosarcoma. (20042639)
2010
16
The aberrant expressions of nuclear matrix proteins during the apoptosis of human osteosarcoma cells. (20340094)
2010
17
Case report: a pediatric case of cementoblastoma with histologic and radiographic features of an osteoblastoma and osteosarcoma. (20737258)
2010
18
How can survival be improved in localized osteosarcoma? (20735316)
2010
19
Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. (20808934)
2010
20
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. (19276372)
2009
21
Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells. (18435913)
2008
22
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. (18171692)
2008
23
Glucose transporter 1 expression in canine osteosarcoma. (19178673)
2008
24
Construction and screening of cDNA library of osteosarcoma cells]. (18159018)
2007
25
Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. (17873971)
2007
26
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. (17598902)
2007
27
Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS. (17022633)
2006
28
Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. (16971354)
2006
29
Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. (15946696)
2005
30
Differential subcellular distribution of estrogen receptor isoforms: localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines. (15993498)
2005
31
Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. (14719113)
2004
32
Telomerase, p53 and PCNA activity in osteosarcoma. (12943619)
2003
33
A fatal case of pleural osteosarcoma mimicking mesothelioma in Paget's disease of bone. (14645873)
2003
34
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. (11498774)
2001
35
Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells. (11855746)
2001
36
Osteosarcoma arising in a solitary osteochondroma of the fibula. (10458834)
1999
37
Modulation of fas-mediated apoptosis in osteosarcoma cell lines. (10568818)
1999
38
Comparative genomic hybridization of low-grade central osteosarcoma. (9619593)
1998
39
Role of glutathione in cisplatin resistance in osteosarcoma cell lines. (9565068)
1998
40
Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. (9793960)
1998
41
P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. (9390540)
1997
42
Presence of double minutes and monosomy 17p in xenografted human osteosarcomas. (8780749)
1996
43
Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. (8631606)
1996
44
Mutational activation of ras genes is absent in pediatric osteosarcoma. (7850751)
1995
45
Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. (8033827)
1994
46
Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. (8052269)
1994
47
Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation. (7962120)
1994
48
Pediatric osteosarcoma - treatment of the primary tumor with intravenous cis-diamminedichloroplatinum-ii (cdp) - comparison of the results with the reported efficacy of intraarterial cdp. (21573359)
1993
49
Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells. (1654784)
1991
50
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974

Genetic Variations for Osteosarcoma

Expression for genes affiliated with Osteosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Osteosarcoma

Search GEO for disease gene expression data for Osteosarcoma.

Pathways for genes affiliated with Osteosarcoma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 56SinoBiological, 54Reactome, 53R&D Systems
See all sources

Pathways related to Osteosarcoma according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.8TNFRSF11A, FOSB, FOS, MDM2, RB1, CHEK2
2
Hide members
11.5TP53, CDK4, CHEK2, RB1, MDM2, FOS
3
Hide members
11.5FOSB, FOS, MDM2, RB1, CHEK2, CDK4
4
Hide members
11.3MDM2, RB1, CHEK2, CDK4, TP53
511.3MDM2, RB1, CHEK2, CDK4, TP53
611.3FOS, RB1, CHEK2, CDK4, TP53
711.3FOS, MDM2, RB1, CDK4, TP53
8
Transcription P53 signaling pathway
Hide members
11.3FOS, MDM2, RB1, CDK4, TP53
9
Hide members
11.3FOS, MDM2, RB1, CHEK2, CDK4
10
Hide members
11.3XRN1, MDM2, RB1, CHEK2, CDK4
11
Hide members
11.1MDM2, RB1, CHEK2, TP53
1211.1MDM2, CHEK2, CDK4, TP53
1311.1MDM2, CHEK2, CDK4, TP53
14
Hide members
11.1MDM2, RB1, CDK4, TP53
1511.1MDM2, RB1, CDK4, TP53
16
Hide members
11.1TP53, CDK4, RB1, MDM2
1711.1TP53, CDK4, RB1, MDM2
18
Hide members
11.1MDM2, RB1, CHEK2, CDK4
1911.1TP53, CDK4, RB1, FOS
20
Hide members
11.1FOS, RB1, CDK4, TP53
21
Cell cycle Cell cycle (generic schema)
Hide members
11.1FOS, RB1, CHEK2, CDK4
2211.1CDK4, CHEK2, RB1, FOS
2311.1TP53, TWIST1, EZR, MDM2
2411.1BGLAP, FOS, MDM2, TP53
25
Hide members
11.1FOSB, FOS, RB1, CDK4
2611.0RB1, CHEK2, TP53
2711.0MDM2, CHEK2, TP53
28
Hide members
11.0TP53, CHEK2, MDM2
2911.0TP53, CHEK2, MDM2
3011.0TP53, RB1, MDM2
3111.0TP53, RB1, MDM2
32
Hide members
11.0RB1, CDK4, TP53
3311.0TP53, CDK4, RB1
3411.0MDM2, CDK4, TP53
3511.0FOS, MDM2, TP53
3611.0FOS, RB1, CDK4
3711.0BGLAP, MDM2, RB1
3811.0TWIST1, RB1, BGLAP
39
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.0FOSB, FOS, TP53
40
Hide members
11.0TP53, FOS, FOSB
4111.0FOSB, FOS, RB1
4210.8TP53, CHEK2
4310.8TP53, CHEK2
4410.8TP53, OS9
4510.6CHEK2
46
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.6TNFRSF11A

Compounds for genes affiliated with Osteosarcoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Osteosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.7BBS9, TNFRSF11A, FOSB, FOS, MDM2, RB1
2cisplatin45 50 60 1115.2BGLAP, FOLR1, MDM2, RB1, CHEK2, CDK4
3oligonucleotide4512.2FOLR1, FOSB, FOS, MDM2, RB1, CHEK2
4vegf4512.2BGLAP, TNFRSF11A, FOS, MDM2, RB1, CDK4
5thymidylate4512.1TP53, SLC19A1, CDK4, RB1, MDM2, FOS
6doxorubicin45 50 1114.1FOLR1, MDM2, RB1, CHEK2, CDK4, SLC19A1
7phosphatidylinositol4512.1TNFRSF11A, FOS, MDM2, RB1, CHEK2, CDK4
8ly2940024511.9FOS, MDM2, RB1, CDK4, EZR, TP53
9genistein45 29 60 2 11 2416.9FOS, MDM2, RB1, CHEK2, CDK4, EZR
10serine4511.7BGLAP, TNFRSF11A, FOSB, FOS, CHEK2
11paclitaxel45 50 1113.7FOLR1, MDM2, RB1, CDK4, TP53
12paraffin4511.7BGLAP, MDM2, CDK4, CD99, EZR
13camptothecin45 60 1113.7MDM2, RB1, CHEK2, CDK4, TP53
14calcitriol45 60 11 2414.7CDK4, RB1, FOS, TNFRSF11A, BGLAP
15okadaic acid45 6012.7FOSB, FOS, RB1, CHEK2, CDK4
165fluorouracil4511.7MDM2, RB1, CDK4, SLC19A1, TP53
1712-o-tetradecanoylphorbol 13-acetate4511.7FOSB, FOS, RB1, CDK4, EZR
18calcium45 50 11 2414.7BGLAP, TNFRSF11A, FOSB, FOS, CDK4, EZR
19sb 20358045 6012.7BGLAP, FOS, RB1, CDK4, TP53
20dexamethasone45 50 29 1114.6CDK4, RB1, MDM2, FOS, BGLAP
21threonine4511.6FOS, MDM2, RB1, CHEK2, CDK4, EZR
22roscovitine4511.6TP53, CDK4, RB1, MDM2
23benzo(a)pyrene4511.6MDM2, RB1, CDK4, TP53
24flavopiridol45 1112.6TP53, CDK4, RB1, MDM2
25carboplatin45 50 1113.5TP53, CDK4, RB1, MDM2
26adpribose4511.5MDM2, RB1, CDK4, TP53
27mitomycin c4511.5TP53, RB1, MDM2, BGLAP
28sp 60012545 6012.5TP53, CDK4, MDM2, FOS
291,25 dihydroxy vitamin d34511.5BGLAP, TNFRSF11A, RB1, CDK4
30adriamycin4511.5MDM2, RB1, CHEK2, TP53
31curcumin4511.4FOS, MDM2, CDK4, TP53
325-aza-2deoxycytidine4511.4FOLR1, MDM2, SLC19A1, TP53
33tomudex4511.4FOLR1, SLC19A1, TP53
34alanine4511.4BGLAP, MDM2, CHEK2, CDK4, EZR, SLC19A1
35bpde4511.4MDM2, CHEK2, TP53
36olomoucine45 1112.4TP53, CDK4, RB1
37aflatoxin b145 2412.3MDM2, RB1, TP53
38thymidine45 2412.3FOS, MDM2, RB1, CDK4, TP53
39aphidicolin4511.3TP53, CHEK2, RB1
40dihydrofolate4511.2FOLR1, RB1, SLC19A1
41n-(4-hydroxyphenyl)retinamide4511.2RB1, CDK4, TP53
42methotrexate45 50 1113.2SLC19A1, RB1, MDM2, FOLR1
43fludarabine45 1112.2TP53, CDK4, MDM2
44vincristine45 50 1113.1SLC19A1, RB1
45n-hydroxysuccinimide4511.1SLC19A1, FOLR1
46hmba4511.0CDK4
47lometrexol4511.0FOLR1, SLC19A1
48somatropin recombinant50 1112.0CDK4, TSPAN31
49agar4510.8CDK4, RB1, MDM2, FOS
50trimetrexate45 1111.8SLC19A1, FOLR1

GO Terms for genes affiliated with Osteosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565411.5TP53, FOS, CTDSP2, MDM2, RB1, CHEK2
2PML bodyGO:01660511.0TP53, CHEK2, RB1
3chromatinGO:00078510.7TP53, CDK4, RB1

Biological processes related to Osteosarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145611.0TP53, TWIST1, MDM2
2response to gravityGO:00962911.0FOS, BGLAP
3folic acid transportGO:01588411.0SLC19A1, FOLR1
4folic acid metabolic processGO:04665510.9FOLR1, SLC19A1
5response to drugGO:04249310.8CDK4, MDM2, FOS, BGLAP
6replicative senescenceGO:09039910.8CHEK2, TP53
7regulation of protein catabolic processGO:04217610.8CHEK2, MDM2
8negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.7MDM2, TWIST1

Molecular functions related to Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.5OS9, CTDSP2, FOS, TNFRSF11A, XRN1, BBS9
2transcription factor bindingGO:00813411.2TP53, TWIST1, RB1, FOS, FOSB
3folic acid bindingGO:00554210.8SLC19A1, FOLR1

Products for genes affiliated with Osteosarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Osteosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet