MCID: OST085
MIFTS: 58

Osteosarcoma, Somatic

Categories: Genetic diseases, Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Osteosarcoma, Somatic

MalaCards integrated aliases for Osteosarcoma, Somatic:

Name: Osteosarcoma, Somatic 54
Osteosarcoma 54 12 50 56 71 29 13 52 42 14 69
Osteogenic Sarcoma 12 50 56 71
Neoplasms, Bone Tissue 42 69
Bone Tissue Neoplasm 12
Osteosarcoma of Bone 69
Skeletal Sarcoma 12
Osteoid Sarcoma 12
Bone Sarcoma 69
Osrc 71

Characteristics:

Orphanet epidemiological data:

56
osteosarcoma
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Childhood;

OMIM:

54
Inheritance:
? autosomal recessive


Classifications:

Orphanet: 56  
Rare bone diseases


External Ids:

OMIM 54 259500
Disease Ontology 12 DOID:3347
NCIt 47 C9145
Orphanet 56 ORPHA668
MESH via Orphanet 43 D012516
UMLS via Orphanet 70 C0029463
ICD10 via Orphanet 34 C41.9
MedGen 40 C0029463

Summaries for Osteosarcoma, Somatic

NIH Rare Diseases : 50 osteosarcoma is the most common type of bone cancer. the average age at diagnosis is 15. boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. in rare cases, osteosarcoma occurs in adults. although osteosarcoma tends to occur in the larger bones, such as the shin (near the knee), thigh (near the knee) and upper arm (near the shoulder), it can occur in any bone.a number of variants of osteosarcoma exist, including conventional types (osteoblastic, chondroblastic, and fibroblastic), telangiectatic, multifocal, parosteal, and periosteal. the cause of osteosarcoma is not known. in some cases, it runs in families, and at least one gene has been linked to increased risk. treatment varies from person to person and may include surgery, chemotherapy, radiation therapy, and samarium. last updated: 9/8/2016

MalaCards based summary : Osteosarcoma, Somatic, also known as osteosarcoma, is related to pediatric osteosarcoma and extraosseous osteosarcoma, and has symptoms including fever, weight loss and osteolysis. An important gene associated with Osteosarcoma, Somatic is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and Apoptosis Modulation and Signaling. The drugs Fusilev and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased substrate adherent cell growth and growth/size/body region

Disease Ontology : 12 A bone cancer that is located in bone that has material basis in cells of mesenchymal origin.

UniProtKB/Swiss-Prot : 71 Osteogenic sarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones.

Description from OMIM: 259500

Related Diseases for Osteosarcoma, Somatic

Diseases related to Osteosarcoma, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
id Related Disease Score Top Affiliating Genes
1 pediatric osteosarcoma 34.4 IGF1R RUNX2 TP53
2 extraosseous osteosarcoma 34.4 CDK4 MDM2 MYC
3 localized osteosarcoma 34.3 BGLAP CDK4 MDM2 MYC
4 metachronous osteosarcoma of the bone 34.0 CDK4 MDM2 SPARC
5 conventional central osteosarcoma 34.0 CDK4 MDM2 PTHLH SPARC
6 small cell osteogenic sarcoma 32.8 CDK4 MDM2 PTHLH
7 spindle cell sarcoma 31.0 CDK4 MDM2 TP53
8 liposarcoma 30.9 MDM2 SPARC
9 papillary carcinoma 30.9 BGLAP SPARC SPP1
10 unilateral retinoblastoma 30.7 CDK4 MDM2 MYC RB1 TP53
11 lung cancer 30.6 CASP3 CDK4 IGF1R MDM2 MMP2 MYC
12 hepatocellular carcinoma 29.9 CASP3 CDK4 MDM2 MMP2 MYC SPP1
13 prostate cancer 28.5 BGLAP CASP3 CDK4 CHEK2 IBSP IGF1R
14 juxtacortical osteosarcoma 11.9
15 adult extraosseous osteosarcoma 11.9
16 bone osteosarcoma 11.9
17 chondroblastic osteosarcoma 11.9
18 breast osteosarcoma 11.9
19 fibrosarcomatous osteosarcoma 11.8
20 osteosarcoma arising in bone paget's disease 11.7
21 peripheral osteosarcoma 11.7
22 childhood extraosseous osteosarcoma 11.7
23 childhood intracortical osteosarcoma 11.7
24 central nervous system osteosarcoma 11.7
25 oslam syndrome 11.5
26 rothmund-thomson syndrome 11.1
27 parathyroid transitional clear cell adenoma 11.1 BGLAP SPARC
28 li-fraumeni syndrome 11.1
29 bone cancer 11.1
30 rapadilino syndrome 11.1
31 rnase t2-deficient leukoencephalopathy 11.1 CDK4 MDM2 TP53
32 skin lipoma 11.0 CDK4 MDM2 RB1
33 ectopic cushing syndrome 11.0 BGLAP BMP2 RUNX2
34 reactive arthritis 11.0 CDK4 EZR MDM2
35 apocrine sweat gland neoplasm 11.0 PTH1R PTHLH SPARC
36 secondary pulmonary hemosiderosis 11.0 CDK4 MDM2 TP53
37 ascaridiasis 11.0 CDK4 MDM2 TP53
38 acute cholinergic dysautonomia 11.0 MDM2 TP53
39 enamel hypoplasia cataract hydrocephaly 11.0 CDK4 MDM2 TP53
40 photoallergic dermatitis 11.0 BGLAP PTHLH
41 lung clear cell-sugar-tumor 11.0 CDK4 MDM2 TP53
42 obesity, severe bmiq9 11.0 BGLAP PTH1R PTHLH
43 prostate transitional cell carcinoma 11.0 CASP3 RB1 TP53
44 polyembryoma 11.0 TNFRSF11B TNFSF11
45 gangliosidosis gm1 11.0 MYC RB1
46 acth-independent macronodular adrenal hyperplasia 11.0 BGLAP BMP2 RUNX2 SPARC
47 gestational choriocarcinoma 11.0 CDK4 MDM2 TP53
48 postmenopausal atrophic vaginitis 11.0 CASP3 MYC TP53
49 mutism 11.0 BGLAP PTH1R PTHLH
50 cystadenoma 11.0 CASP3 MYC TP53

Graphical network of the top 20 diseases related to Osteosarcoma, Somatic:



Diseases related to Osteosarcoma, Somatic

Symptoms & Phenotypes for Osteosarcoma, Somatic

Symptoms via clinical synopsis from OMIM:

54

Lab:
osteogenic sarcoma
high alkaline phoshphatase
rearrangements involving chromosomes 13 and 14
loss of heterozygosity of chromosomes 13 and 17

Misc:
increased incidence in retinoblastoma cases
peak freqency in adolescence

Skel:
painful tender mass at long bone metaphysis

Radiology:
bone destruction and mineralized soft tissue mass


Clinical features from OMIM:

259500

Human phenotypes related to Osteosarcoma, Somatic:

56 32 (show all 14)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 56 32 very rare (1%) Very rare (<4-1%) HP:0001945
2 weight loss 56 32 very rare (1%) Very rare (<4-1%) HP:0001824
3 osteolysis 56 32 hallmark (90%) Very frequent (99-80%) HP:0002797
4 joint swelling 56 32 frequent (33%) Frequent (79-30%) HP:0001386
5 elevated alkaline phosphatase 56 32 frequent (33%) Frequent (79-30%) HP:0003155
6 pain 56 32 frequent (33%) Frequent (79-30%) HP:0012531
7 pathologic fracture 56 32 very rare (1%) Very rare (<4-1%) HP:0002756
8 abnormal lactate dehydrogenase activity 56 32 frequent (33%) Frequent (79-30%) HP:0045040
9 abnormality of the femoral metaphysis 56 32 hallmark (90%) Very frequent (99-80%) HP:0006489
10 abnormality of the tibial metaphysis 56 32 frequent (33%) Frequent (79-30%) HP:0006491
11 osteosarcoma 32 HP:0002669
12 retinoblastoma 32 HP:0009919
13 abnormality of metabolism/homeostasis 32 HP:0001939
14 abnormality of the metaphyses 56 Frequent (79-30%)

GenomeRNAi Phenotypes related to Osteosarcoma, Somatic according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.5 IGF1R
2 Decreased substrate adherent cell growth GR00193-A-2 9.5 CDK4
3 Decreased substrate adherent cell growth GR00193-A-3 9.5 CDK4 CHEK2
4 Decreased substrate adherent cell growth GR00193-A-4 9.5 IGF1R CDK4 CHEK2
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP3 CHEK2 RB1 TNFRSF11B TP53
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP3 CHEK2 IGF1R MYC RB1 TNFRSF11B

MGI Mouse Phenotypes related to Osteosarcoma, Somatic:

44 (show all 24)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.53 EZR IBSP IGF1R MDM2 MMP2 MYC
2 hematopoietic system MP:0005397 10.51 CDK4 CHEK2 EZR IBSP IGF1R MDM2
3 immune system MP:0005387 10.49 SPARC SPP1 TNFRSF11B TNFSF11 TP53 BMP2
4 craniofacial MP:0005382 10.47 BMP2 CASP3 IGF1R MDM2 MMP2 MYC
5 homeostasis/metabolism MP:0005376 10.45 BMP2 CASP3 CDK4 CHEK2 IGF1R MDM2
6 cardiovascular system MP:0005385 10.42 BMP2 CASP3 CDK4 IGF1R MDM2 MMP2
7 cellular MP:0005384 10.42 BMP2 CASP3 CDK4 CHEK2 IGF1R MDM2
8 mortality/aging MP:0010768 10.41 MDM2 MMP2 MYC PTH1R PTHLH RB1
9 behavior/neurological MP:0005386 10.4 CDK4 IGF1R MDM2 MYC PTH1R PTHLH
10 digestive/alimentary MP:0005381 10.37 CDK4 BMP2 CASP3 EZR IGF1R MDM2
11 endocrine/exocrine gland MP:0005379 10.32 CASP3 CDK4 CHEK2 IGF1R MDM2 MYC
12 limbs/digits/tail MP:0005371 10.32 BMP2 IBSP IGF1R MDM2 MYC PTH1R
13 integument MP:0010771 10.3 CASP3 CDK4 IGF1R MDM2 MYC PTHLH
14 nervous system MP:0003631 10.22 BMP2 CASP3 CDK4 CHEK2 IGF1R MDM2
15 muscle MP:0005369 10.2 CASP3 CDK4 IGF1R MDM2 MMP2 MYC
16 neoplasm MP:0002006 10.17 CDK4 CHEK2 IGF1R MDM2 MMP2 MYC
17 hearing/vestibular/ear MP:0005377 10.11 BMP2 CASP3 IGF1R MYC RB1 TNFRSF11B
18 liver/biliary system MP:0005370 10.1 IGF1R MDM2 MYC RB1 RUNX2 SPP1
19 reproductive system MP:0005389 10.03 PTHLH RB1 RUNX2 SPP1 TNFSF11 TP53
20 pigmentation MP:0001186 9.91 CASP3 CDK4 MDM2 MYC RB1 SPARC
21 renal/urinary system MP:0005367 9.87 CASP3 CDK4 MDM2 PTHLH RB1 SPP1
22 skeleton MP:0005390 9.86 MMP2 MYC PTH1R PTHLH BMP2 RB1
23 respiratory system MP:0005388 9.85 CASP3 IGF1R MMP2 PTH1R PTHLH RB1
24 vision/eye MP:0005391 9.28 CASP3 CDK4 MMP2 PTHLH RB1 RUNX2

Drugs & Therapeutics for Osteosarcoma, Somatic

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Fusilev 17 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals March of 2008

Drugs for Osteosarcoma, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Antibodies, Monoclonal Phase 2
4 Immunoglobulins Phase 2
5 Alkylating Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma Not yet recruiting NCT02982486 Phase 2 Ipilimumab;Nivolumab
2 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
3 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274

Search NIH Clinical Center for Osteosarcoma, Somatic

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: osteosarcoma

Genetic Tests for Osteosarcoma, Somatic

Genetic tests related to Osteosarcoma, Somatic:

id Genetic test Affiliating Genes
1 Osteosarcoma 29

Anatomical Context for Osteosarcoma, Somatic

MalaCards organs/tissues related to Osteosarcoma, Somatic:

39
Bone

Publications for Osteosarcoma, Somatic

Articles related to Osteosarcoma, Somatic:

id Title Authors Year
1
Analysis of oncogene, tumor suppressor gene, and chromosomal alterations in HeLa x osteosarcoma somatic cell hybrids. ( 10331742 )
1999

Variations for Osteosarcoma, Somatic

ClinVar genetic disease variations for Osteosarcoma, Somatic:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CHEK2 NM_007194.3(CHEK2): c.49G> T (p.Ala17Ser) single nucleotide variant Pathogenic rs137853008 GRCh37 Chromosome 22, 29130661: 29130661
2 TP53 NM_000546.5(TP53): c.722C> T (p.Ser241Phe) single nucleotide variant Pathogenic/Likely pathogenic rs28934573 GRCh37 Chromosome 17, 7577559: 7577559
3 TP53 NM_000546.5(TP53): c.475_481dupGCCATGG (p.Ala161Glyfs) duplication Pathogenic rs863223301 GRCh38 Chromosome 17, 7675131: 7675137
4 AKT1 NM_005163.2(AKT1): c.49G> A (p.Glu17Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121434592 GRCh37 Chromosome 14, 105246551: 105246551

Cosmic variations for Osteosarcoma, Somatic:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM866 RB1 bone,NS,osteosarcoma,osteoblastic c.1399C>T p.R467* 10
2 COSM1034 RB1 bone,NS,osteosarcoma,chondroblastic c.1499-1G>T p.? 10
3 COSM27887 GNAS bone,NS,osteosarcoma,parosteal c.601C>T p.R201C 10
4 COSM27895 GNAS bone,NS,osteosarcoma,parosteal c.602G>A p.R201H 10

Copy number variations for Osteosarcoma, Somatic from CNVD:

7 (show top 50) (show all 688)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 17390 1 142600000 150300000 Gain Osteosarcoma
2 17391 1 142600000 155000000 Amplification Osteosarcoma
3 39243 10 112373403 112374403 Gain Osteosarcoma
4 39244 10 112373452 112374452 Loss Osteosarcoma
5 41292 10 15522819 15523819 Loss Osteosarcoma
6 41294 10 15581536 15582536 Loss Osteosarcoma
7 46318 10 80680600 80681600 Loss Osteosarcoma
8 46347 10 80806585 80807585 Loss Osteosarcoma
9 58796 11 69623478 69623778 Gain Osteosarcoma
10 58827 11 69805619 69805919 Loss Osteosarcoma
11 60316 11 85062165 85063165 Gain Osteosarcoma
12 60323 11 85134471 85135471 Gain Osteosarcoma
13 62537 12 10955611 10956611 Gain Osteosarcoma
14 62568 12 10980072 10981072 Gain Osteosarcoma
15 62603 12 11027103 11028103 Loss Osteosarcoma
16 63038 12 11366981 11367981 Gain Osteosarcoma
17 63258 12 11668570 11669570 Gain Osteosarcoma
18 63272 12 11686468 11687468 Loss Osteosarcoma
19 64267 12 12569624 12570624 Loss Osteosarcoma
20 64268 12 12573054 12574054 Loss Osteosarcoma
21 64280 12 12586928 12587928 Gain Osteosarcoma
22 64287 12 12597865 12598865 Loss Osteosarcoma
23 64343 12 12687540 12688540 Gain Osteosarcoma
24 64577 12 12982393 12983393 Gain Osteosarcoma
25 64986 12 14117741 14118741 Loss Osteosarcoma
26 64996 12 14185562 14186562 Gain Osteosarcoma
27 64998 12 14245323 14246323 Gain Osteosarcoma
28 65344 12 16046949 16047949 Gain Osteosarcoma
29 65345 12 16049923 16050923 Loss Osteosarcoma
30 65347 12 16051037 16052037 Gain Osteosarcoma
31 65348 12 16051062 16052062 Loss Osteosarcoma
32 65349 12 16054806 16055806 Gain Osteosarcoma
33 65384 12 16430865 16431865 Gain Osteosarcoma
34 65385 12 16433142 16434142 Loss Osteosarcoma
35 65386 12 16436484 16437484 Gain Osteosarcoma
36 65391 12 16463017 16464017 Gain Osteosarcoma
37 65392 12 16466398 16467398 Gain Osteosarcoma
38 65400 12 16603247 16604247 Loss Osteosarcoma
39 65436 12 17462418 17463418 Gain Osteosarcoma
40 65437 12 17462804 17463804 Loss Osteosarcoma
41 65493 12 1815281 1816281 Loss Osteosarcoma
42 65649 12 20337069 20338069 Gain Osteosarcoma
43 65959 12 23459482 23460482 Loss Osteosarcoma
44 65979 12 23822360 23823360 Loss Osteosarcoma
45 66478 12 29963884 29964884 Loss Osteosarcoma
46 66480 12 29986214 29987214 Gain Osteosarcoma
47 66482 12 30002256 30003256 Loss Osteosarcoma
48 66483 12 30014548 30015548 Loss Osteosarcoma
49 66485 12 30029899 30030899 Loss Osteosarcoma
50 67171 12 37173408 37174408 Loss Osteosarcoma

Expression for Osteosarcoma, Somatic

Search GEO for disease gene expression data for Osteosarcoma, Somatic.

Pathways for Osteosarcoma, Somatic

Pathways related to Osteosarcoma, Somatic according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 BMP2 CASP3 CDK4 CHEK2 EZR IGF1R
2
Show member pathways
12.86 CASP3 IGF1R MDM2 MYC TNFRSF11B TP53
3
Show member pathways
12.8 BMP2 CASP3 IBSP MMP2 SPARC SPP1
4
Show member pathways
12.73 CDK4 CHEK2 MDM2 MYC RB1 TP53
5 12.72 CASP3 CDK4 IBSP IGF1R MDM2 MYC
6
Show member pathways
12.62 CDK4 MDM2 MYC RB1 TP53
7
Show member pathways
12.61 CASP3 CDK4 IGF1R MDM2 MYC RB1
8 12.57 BMP2 CASP3 CDK4 IGF1R MDM2 MMP2
9 12.56 CASP3 EZR MDM2 MYC TP53
10 12.55 CDK4 CHEK2 MDM2 RB1 TP53
11
Show member pathways
12.54 CASP3 MDM2 MYC TP53
12
Show member pathways
12.5 CASP3 CHEK2 IGF1R MDM2 TP53
13 12.48 CDK4 CHEK2 MYC RB1 TP53
14 12.44 CDK4 CHEK2 MDM2 MYC RB1 TP53
15
Show member pathways
12.43 CASP3 CDK4 CHEK2 MDM2 MYC RB1
16
Show member pathways
12.42 IGF1R MDM2 MYC TP53
17 12.36 CASP3 CDK4 MDM2 RB1 TP53
18 12.33 MDM2 MYC RB1 TP53
19
Show member pathways
12.33 CASP3 CDK4 CHEK2 MDM2 RB1 TP53
20
Show member pathways
12.32 CASP3 CDK4 IGF1R MDM2 MYC RB1
21 12.31 IGF1R MDM2 MYC RUNX2 TP53
22 12.31 CASP3 EZR IGF1R MDM2 MMP2 MYC
23
Show member pathways
12.27 CDK4 CHEK2 MYC RB1
24 12.23 CASP3 MMP2 MYC TP53
25
Show member pathways
12.16 EZR IGF1R MDM2 MMP2
26 12.14 MDM2 MMP2 RB1 SPP1 TP53
27 12.14 CASP3 CDK4 CHEK2 MDM2 MYC RB1
28 12.12 CDK4 CHEK2 MDM2 TP53
29 12.11 BMP2 MDM2 MMP2 RB1 TP53
30 12.09 CASP3 CDK4 MYC RB1 TP53
31 12.03 CDK4 IGF1R MDM2 MYC RB1 TP53
32 11.98 BGLAP BMP2 RUNX2 SPARC SPP1
33 11.98 BMP2 IGF1R MDM2 RB1 SPARC TP53
34 11.93 CDK4 MDM2 MYC RB1 TP53
35 11.91 CASP3 CDK4 MYC RB1 TP53
36
Show member pathways
11.86 CHEK2 MDM2 TP53
37
Show member pathways
11.84 CHEK2 RB1 TP53
38 11.83 BGLAP MDM2 TP53
39 11.82 CDK4 MYC TP53
40 11.8 CDK4 MYC RUNX2
41 11.77 CASP3 MDM2 TP53
42
Show member pathways
11.77 CHEK2 MDM2 TP53
43 11.77 CDK4 IGF1R MYC RB1
44 11.76 IGF1R PTH1R PTHLH RUNX2 SPP1
45 11.72 CASP3 EZR MMP2
46 11.72 CHEK2 MYC TP53
47 11.71 EZR IGF1R MMP2 SPARC
48 11.71 CDK4 MDM2 MMP2 MYC RB1 TP53
49 11.67 CHEK2 MDM2 TP53
50 11.67 BGLAP MDM2 RB1 RUNX2

GO Terms for Osteosarcoma, Somatic

Cellular components related to Osteosarcoma, Somatic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 BGLAP BMP2 EZR IBSP MMP2 PTHLH
2 vesicle GO:0031982 9.02 BGLAP EZR IBSP SPARC SPP1

Biological processes related to Osteosarcoma, Somatic according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.95 BMP2 CASP3 MDM2 SPARC
2 positive regulation of gene expression GO:0010628 9.95 BMP2 EZR MDM2 MYC RUNX2 TP53
3 positive regulation of cell proliferation GO:0008284 9.95 CDK4 IGF1R MDM2 MYC PTH1R PTHLH
4 regulation of gene expression GO:0010468 9.91 CDK4 MDM2 MYC PTHLH
5 extracellular matrix organization GO:0030198 9.91 IBSP SPARC SPP1 TNFRSF11B
6 response to drug GO:0042493 9.91 BGLAP CASP3 CDK4 MDM2 MYC TNFRSF11B
7 cellular response to organic cyclic compound GO:0071407 9.82 BMP2 CASP3 MDM2
8 response to glucocorticoid GO:0051384 9.81 BGLAP CASP3 SPARC
9 cellular response to drug GO:0035690 9.8 CHEK2 MYC TP53
10 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.77 CHEK2 MDM2 TP53
11 osteoblast differentiation GO:0001649 9.77 BGLAP BMP2 IBSP RUNX2 SPP1
12 negative regulation of cell cycle GO:0045786 9.75 BMP2 CASP3 RB1
13 chondrocyte differentiation GO:0002062 9.74 BMP2 PTH1R RUNX2
14 biomineral tissue development GO:0031214 9.73 BGLAP IBSP SPP1
15 skeletal system development GO:0001501 9.73 BGLAP BMP2 PTH1R PTHLH RUNX2 TNFRSF11B
16 response to antibiotic GO:0046677 9.72 CASP3 MDM2 TP53
17 response to gamma radiation GO:0010332 9.71 CHEK2 MYC TP53
18 cellular response to gamma radiation GO:0071480 9.69 CHEK2 MDM2 TP53
19 negative regulation of cell cycle arrest GO:0071157 9.67 CDK4 CHEK2 MDM2
20 response to magnesium ion GO:0032026 9.66 MDM2 TNFRSF11B
21 replicative senescence GO:0090399 9.66 CHEK2 TP53
22 atrioventricular valve morphogenesis GO:0003181 9.65 BMP2 MDM2
23 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.64 BMP2 RUNX2
24 response to gravity GO:0009629 9.62 BGLAP SPARC
25 bone mineralization GO:0030282 9.62 BGLAP BMP2 IBSP PTH1R
26 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.59 BMP2 RUNX2
27 glial cell apoptotic process GO:0034349 9.58 CASP3 RB1
28 cellular response to actinomycin D GO:0072717 9.52 MDM2 TP53
29 osteoblast development GO:0002076 9.46 BGLAP PTH1R PTHLH RUNX2
30 cellular response to growth factor stimulus GO:0071363 9.35 BGLAP BMP2 IBSP MDM2 SPARC
31 ossification GO:0001503 9.1 BGLAP BMP2 PTH1R RUNX2 SPARC TNFSF11
32 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10.11 BMP2 EZR MDM2 MYC RB1 TP53
33 negative regulation of cell proliferation GO:0008285 10.02 BMP2 PTH1R PTHLH RB1 TP53
34 positive regulation of transcription, DNA-templated GO:0045893 10 BMP2 CHEK2 MYC RB1 RUNX2 SPP1

Molecular functions related to Osteosarcoma, Somatic according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.56 CASP3 CDK4 EZR MYC
2 identical protein binding GO:0042802 9.55 CHEK2 IGF1R MDM2 RB1 TP53
3 cytokine activity GO:0005125 9.26 BMP2 SPP1 TNFRSF11B TNFSF11
4 disordered domain specific binding GO:0097718 8.92 EZR MDM2 RB1 TP53

Sources for Osteosarcoma, Somatic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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