Osteosclerosis disease: drugs, articles, genes, clinical trials

Summaries for Osteosclerosis

Sources:
⁶Disease Ontology, ⁴⁴Wikipedia, ³³OMIM, ²²MalaCards
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Wikipedia: Osteosclerosis, an elevation in bone density, is normally detected on a radiograph as an area of...⁴⁴ more...

MalaCards: Osteosclerosis is related to craniodiaphyseal dysplasia and osteopetrosis. An important gene associated with Osteosclerosis is CTSK (cathepsin K), and among its related pathways are TRAIL Pathway and Apoptotic Pathways in Synovial Fibroblasts. The compounds pge2 and denosumab have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and b cells, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A bone remodeling disease that results in abnormal elevated bone density or mass.⁶

OMIM: 144750

Aliases & Descriptions for Osteosclerosis

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Sources:
⁶Disease Ontology, ³³OMIM, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ²⁷NCIt, ²⁴MeSH, ⁴⁰SNOMED-CT
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Aliases & Descriptions:

osteosclerosis ⁶ ³³ ⁸ ³² ⁴³

External Ids:

NCIt²⁷ C41236

SNOMED-CT⁴⁰ 49347007

MeSH²⁴ D010026

UMLS⁴³ C0029464

Related Diseases for Osteosclerosis

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to osteosclerosis by text searches and GeneDecks gene sharing:

(show top 50) (show all 275)

id	Related Disease	Score	Top Affiliating Genes
1	craniodiaphyseal dysplasia	27.9	LRP5, SOST
2	osteopetrosis	27.7	LRP5, BGLAP, TNFRSF11A, TNFRSF11B, TNFSF11, CTSK
3	camurati-engelmann disease	27.2	LRP5, BGLAP
4	pseudohypoparathyroidism	26.9	BGLAP, PTH, STX16
5	poems syndrome	26.6	VEGFA, BGLAP, TNFRSF11B, TNFSF11
6	myelofibrosis	26.4	VEGFA, BMP2, CD40LG, IL11, IFNA2, TNFRSF11B
7	hyperostosis	26.1	LRP5, BGLAP, ALPL, TNFRSF11B, PTH, SOST
8	beta thalassemia	25.5	BGLAP, IFNA2, ALPP, TNFRSF11B, TNFSF11
9	thalassemia	24.9	BGLAP, IFNA2, ALPP, TNFRSF11B, TNFSF11, PTH
10	hepatitis c	24.5	VEGFA, CD40LG, IL11, IGF2, IGFBP2, IFNA2
11	hyperparathyroidism	23.0	LRP5, VEGFA, BMP2, BGLAP, IGF2, IGFBP2
12	hepatitis	22.8	VEGFA, BGLAP, CD40LG, FOSL1, IL11, IGF2
13	diabetes mellitus	21.2	LRP5, VEGFA, BMP2, BGLAP, CD40LG, IGF2
14	carcinoma	19.1	LRP5, VEGFA, BMP2, BGLAP, CD40LG, FOSL1
15	osteoporosis	19.0	LRP5, VEGFA, BMP2, BGLAP, CD40LG, FOSL1
16	leukemia	18.9	LRP5, VEGFA, BMP2, BGLAP, CD40LG, FOSL1
17	chronic apical periodontitis	13.6	TNFRSF11B, TNFSF11
18	sost-related sclerosing bone dysplasia	13.5	LRP5, SOST
19	mass syndrome	13.5	LRP5, SOST
20	aortic valve stenosis	13.5	BMP2, TNFRSF11B, TNFSF11
21	acquired thrombocytopenia	13.5	IL11, THPO
22	bone resorption disease	13.4	TNFRSF11A, TNFSF11
23	multicentric reticulohistiocytosis	13.4	TNFRSF11B, TNFSF11
24	androgen insensitivity syndrome	13.4	IGF2, IGFBP2, ALPPL2
25	ankylosis	13.4	BMP2, TNFRSF11B, SP7
26	joint disorders	13.3	IL11, TNFRSF11B, TNFSF11
27	paget disease, juvenile	13.3	TNFRSF11A, TNFRSF11B, TNFSF11
28	polyostotic osteolytic dysplasia, hereditary expansile	13.3	TNFRSF11A, TNFRSF11B, TNFSF11
29	osteopetrosis autosomal dominant type 2	13.3	BGLAP, TNFSF11
30	hypophosphatasia	13.2	ALPL, ALPP
31	villonodular synovitis	13.2	BGLAP, TNFRSF11B, TNFSF11
32	osteopenia/osteoporosis	13.2	BGLAP, TNFRSF11B, TNFSF11
33	clear cell adenoma	13.2	ALPP, PTH
34	mammary paget's disease	13.1	BGLAP, TNFRSF11B, TNFSF11
35	pigmented villonodular synovitis	13.1	BGLAP, TNFRSF11B, TNFSF11
36	transsexualism	13.1	BGLAP, TNFRSF11B, TNFSF11
37	common bile duct disease	13.1	ALPL, ALPP, ALPPL2
38	uremia	13.1	IGFBP2, TNFRSF11B, PTH, THPO
39	testicular neoplasm	13.0	ALPL, ALPP, ALPPL2
40	acrodermatitis enteropathica	13.0	ALPL, ALPP, ALPPL2
41	cleidocranial dysplasia	13.0	BMP2, BGLAP, ALPL
42	gallbladder disease	13.0	ALPL, ALPP, ALPPL2
43	vitamin d-dependent rickets type ii	13.0	BGLAP, PTH
44	root resorption	13.0	BMP2, TNFRSF11A, TNFRSF11B, TNFSF11, CTSK
45	monoclonal gammopathy of undetermined significance	13.0	CD40LG, TNFRSF11B, TNFSF11
46	dysgerminoma	13.0	ALPL, ALPP, ALPPL2
47	smooth muscle tumor	13.0	VEGFA, BMP2, IGF2
48	pseudohypoparathyroidism type ib	12.9	BGLAP, PTH, STX16
49	crigler-najjar syndrome	12.9	ALPL, ALPP, ALPPL2
50	humoral hypercalcemia of malignancy	12.9	BGLAP, TNFRSF11A, TNFSF11

Graphical network of the top 20 diseases related to osteosclerosis:

Graphical network of diseases related to osteosclerosis

Clinical Features for Osteosclerosis

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Sources:
³³OMIM
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Clinical features from OMIM: 144750

Drugs & Therapeutics for Osteosclerosis

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

Search CenterWatch for osteosclerosis

Drug clinical trials:

Search ClinicalTrials for osteosclerosis

Search NIH Clinical Center for osteosclerosis

Search CenterWatch for osteosclerosis

Genetic Tests for Osteosclerosis

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Anatomical Context for Osteosclerosis

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²²MalaCards
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MalaCards organs/tissues related to osteosclerosis:

²²

Brain, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Osteosclerosis

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²⁵MGI
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MGI Mouse Phenotypes related to osteosclerosis:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.7	SP7, TBCE, ALPL
2	craniofacial phenotype	MP:0005382	9.3	LTBP3, CTSK, PTH, ALPL, FAM20C, LRP5
3	immune system phenotype	MP:0005387	9.1	LTBP3, CTSK, PTH, AIRE, ALPL, IGFBP2
4	endocrine/exocrine gland phenotype	MP:0005379	8.7	CTSK, PTH, AIRE, FAM20C, CD40LG, LRP5
5	hematopoietic system phenotype	MP:0005397	8.5	THPO, CTSK, PTH, TNFSF11, TNFRSF11A, ALPL
6	reproductive system phenotype	MP:0005389	8.3	TNFSF11, TNFRSF11A, ALPP, ALPL, FAM20C, BMP2
7	normal phenotype	MP:0002873	8.1	PDLIM3, AIRE, ALPP, IGFBP2, FOSL1, BMP2
8	cardiovascular system phenotype	MP:0005385	7.9	PDLIM3, PTH, TNFRSF11B, ALPL, IGFBP2, IGF2
9	limbs/digits/tail phenotype	MP:0005371	7.5	TNFSF11, PTH, SP7, CTSK, SOST, TNFRSF11B
10	skeleton phenotype	MP:0005390	7.1	VEGFA, SOST, LTBP3, CTSK, SP7, PTH
11	mortality/aging	MP:0010768	6.9	TNFRSF11B, TNFSF11, PTH, TBCE, SP7, PDLIM3
12	cellular phenotype	MP:0005384	6.6	AIRE, TNFRSF11A, TNFRSF11B, TNFSF11, SP7, ALPL
13	growth/size phenotype	MP:0005378	6.4	TNFRSF11A, TNFRSF11B, TNFSF11, PTH, CTSK, LTBP3
14	homeostasis/metabolism phenotype	MP:0005376	6.4	TNFSF11, SP7, CTSK, PDLIM3, SOST, SLC22A8

Publications for genes affiliated with Osteosclerosis

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³⁵PubMed
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Articles related to osteosclerosis:

(show all 16)

id	Title	Authors	Year	Affiliating Genes
1	Osteosclerosis in two brothers with autosomal dominan t pseudohypoparathyroidism type 1b: bone histomorphometric analysis. (21062889)	Sbrocchi A.M.... Ward L.M.	2011	STX16
2	VEGF and osteosclerosis in POEMS syndrome. (18172647)	GA1tgemann I.... George T.I.	2008	VEGFA
3	Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice. (17374740)	Wagner-Ballon O.... Giraudier S.	2007	TNFRSF11B, THPO
4	Osteoporosis and osteosclerosis in sickle cell/beta-thalassemia: the role of the RANKL/osteoprotegerin axis. (16704959)	Voskaridou E.... Terpos E.	2006	TNFSF11, TNFRSF11B
5	A case of hepatitis C-associated osteosclerosis in an elderly Japanese man. (16717394)	Tanaka T.... Hashimoto J.	2006	PDLIM3
6	Case of intraspinal epidural tumor developing after systemic mastocytosis with marked osteosclerosis and myelofibrosis (16440779)	Ohnishi K.... Kohgo Y.	2005	IFNA2
7	Osteosclerosis in advanced chronic idiopathic myelofibrosis is associated with endothelial overexpression of osteoprotegerin. (15982347)	Bock O.... Kreipe H.	2005	TNFRSF11B, TNFSF11
8	Osteosclerosis in idiopathic myelofibrosis is related to the overproduction of osteoprotegerin (OPG). (15504545)	Wang J.C.... Jabara M.	2004	TNFRSF11B
9	Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. (15307108)	Sato T.... Niitsu Y.	2004	TNFRSF11B, IL11
10	Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. (14762099)	Ohtsuki S.... Terasaki T.	2004	SLC22A8
11	Autosomal dominant hyperostosis/osteosclerosis with high serum alkaline phosphatase activity. (12788869)	Hernandez-Cassis C.... Iglesias Gamarra A.	2003	ALPL
12	A novel AIRE mutation in an APECED patient with candidiasis, adrenal failure, hepatitis, diabetes mellitus and osteosclerosis. (12784192)	Vogel A.... Manns M.P.	2003	AIRE
13	Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis. (12161524)	Khosla S.... Conover C.A.	2002	IGF2, IGFBP2
14	Hyperparathyroidism and increased serum IGF-binding protein-2 levels in hepatitis C-associated osteosclerosis. (9920116)	Shaker J.L.... Whyte M.P.	1999	IGFBP2
15	Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder. (9817940)	Liel Y.... Lowenthal M.N.	1998	ALPP
16	Painful diffuse osteosclerosis after intravenous drug abuse. (1329508)	Villareal D.T.... Whyte M.P.	1992	CD40LG, BGLAP

Genes related to Osteosclerosis

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¹³GeneCards
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Genes related to osteosclerosis according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	CTSK	cathepsin K	11.1	Summaries
2	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
3	THPO	thrombopoietin	11.0	Publications
4	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
5	LRP5	low density lipoprotein receptor-related protein 5	11.0
6	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
7	BMP2	bone morphogenetic protein 2	11.0
8	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
9	STX16	syntaxin 16	11.0	Publications
10	SLC22A8	solute carrier family 22 (organic anion transporter), member 8	11.0	Publications
11	PDLIM3	PDZ and LIM domain 3	11.0	Publications
12	AIRE	autoimmune regulator	11.0	Publications
13	FAM20C	family with sequence similarity 20, member C	11.0
14	SOST	sclerostin	11.0
15	SP7	Sp7 transcription factor	11.0
16	LTBP3	latent transforming growth factor beta binding protein 3	11.0
17	ALPPL2	alkaline phosphatase, placental-like 2	11.0
18	ALPL	alkaline phosphatase, liver/bone/kidney	11.0	Publications
19	TBCE	tubulin folding cofactor E	11.0
20	FOSL1	FOS-like antigen 1	11.0
21	IL11	interleukin 11	11.0	Publications
22	PTH	parathyroid hormone	11.0
23	TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	11.0
24	ALPP	alkaline phosphatase, placental	11.0	Publications
25	IFNA2	interferon, alpha 2	11.0	Publications
26	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
27	CD40LG	CD40 ligand	11.0	Publications
28	VEGFA	vascular endothelial growth factor A	11.0	Publications

Expression for genes affiliated with Osteosclerosis

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Osteosclerosis

Pathways for genes affiliated with Osteosclerosis

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³⁶QIAGEN, ²⁰KEGG, ¹⁰EMD Millipore, ⁴¹Thomson Reuters
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Pathways related to osteosclerosis according to GeneDecks:

(show all 29)

id	Pathway	Score	Top Affiliating Genes
1	TRAIL Pathway³⁶	10.0	TNFRSF11A, TNFRSF11B, TNFSF11
2	Apoptotic Pathways in Synovial Fibroblasts³⁶	9.9	BMP2, IGF2, LTBP3, THPO
3	p53 Mediated Apoptosis³⁶	9.9	THPO, LTBP3, IGF2, BMP2
4	Glioma Invasiveness³⁶	9.8	THPO, LTBP3, IGF2, BMP2
5	Folate biosynthesis²⁰	9.8	ALPL, ALPP, ALPPL2
6	Telomerase Components in Cell Signaling³⁶	9.8	THPO, LTBP3, BMP2
7	ERK5 Signaling³⁶	9.7	THPO, LTBP3, IGF2, FOSL1, BMP2
8	TGF-Beta Pathway³⁶	9.7	THPO, LTBP3, IGF2, IL11, BMP2
9	Osteoclast differentiation²⁰	9.6	CTSK, TNFSF11, TNFRSF11B, TNFRSF11A, FOSL1
10	NAD metabolism¹⁰	9.6	ALPL, ALPPL2
11	Development_Hedgehog and PTH signaling pathways in bone and cartilage development⁴¹	9.6	BGLAP, TNFSF11, PTH
12	Development Hedgehog and PTH signaling pathways in bone and cartilage development¹⁰	9.6	PTH, TNFSF11, BGLAP
13	PAK Pathway³⁶	9.5	THPO, LTBP3, TNFSF11, IGF2, IL11, BMP2
14	Molecular Mechanisms of Cancer³⁶	9.5	LTBP3, TNFSF11, IGF2, IL11, BMP2, LRP5
15	NAD metabolism⁴¹	9.5	ALPL, ALPP, ALPPL2
16	Rho Family GTPases³⁶	9.4	THPO, LTBP3, TNFSF11, IGF2, IL11, BMP2
17	MAPK Family Pathway³⁶	9.4	THPO, LTBP3, IGF2, IL11, BMP2
18	Akt Signaling³⁶	9.3	THPO, LTBP3, TNFSF11, TNFRSF11A, IL11, BMP2
19	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway⁴¹	9.3	TNFSF11, TNFRSF11A, CD40LG
20	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway¹⁰	9.3	TNFSF11, TNFRSF11A, CD40LG
21	Tec Kinases Signaling³⁶	9.3	THPO, LTBP3, TNFRSF11A, IGF2, IL11, BMP2
22	Rheumatoid arthritis²⁰	9.3	CTSK, TNFSF11, TNFRSF11A, IL11, VEGFA
23	ERK Signaling³⁶	9.2	THPO, LTBP3, TNFSF11, IGF2, IL11, BMP2
24	JAK-STAT Pathway³⁶	9.2	THPO, LTBP3, IFNA2, IGF2, IL11, BMP2
25	Antioxidant Action of Vitamin-C³⁶	9.2	THPO, LTBP3, TNFSF11, TNFRSF11A, IGF2, IL11
26	p38 Signaling³⁶	8.8	THPO, LTBP3, TNFSF11, TNFRSF11A, IGF2, IL11
27	Transcription_Role of VDR in regulation of genes involved in osteoporosis⁴¹	8.8	BGLAP, FOSL1, TNFRSF11A, TNFRSF11B, TNFSF11, PTH
28	Transcription Role of VDR in regulation of genes involved in osteoporosis¹⁰	8.8	PTH, TNFSF11, TNFRSF11B, TNFRSF11A, FOSL1, BGLAP
29	Cytokine-cytokine receptor interaction²⁰	7.7	TNFSF11, TNFRSF11B, TNFRSF11A, IFNA2, IL11, CD40LG

Compounds for genes affiliated with Osteosclerosis

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³²Novoseek , ⁹DrugBank, ⁴²Tocris Bioscience, ³⁴PharmGKB, ¹⁸HMDB
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Compounds related to osteosclerosis according to GeneDecks:

(show top 50) (show all 125)

id	Compound	Score	Top Affiliating Genes
1	pge2³²	10.0	TNFSF11, TNFRSF11B, BMP2, TNFRSF11A
2	denosumab³²	9.9	TNFSF11, TNFRSF11B, SOST, TNFRSF11A
3	phosphorus³²	9.8	TNFSF11, ALPP, PTH
4	teriparatide³² ⁹ ⁹	11.7	BGLAP, TNFRSF11B, TNFSF11, CTSK
5	amifostine³² ⁹ ⁹	11.7	ALPPL2, THPO, ALPL, IL11
6	polyethylene³²	9.4	CTSK, TNFRSF11B, TNFRSF11A, IFNA2, TNFSF11, THPO
7	vitamin k2³²	9.4	TNFRSF11B, TNFSF11, ALPP, BGLAP
8	tartrate³²	9.3	BGLAP, ALPP, TNFSF11, CTSK
9	risedronate³² ⁴² ⁹ ⁹	12.3	TNFRSF11B, TNFSF11, BGLAP, ALPP
10	raloxifene³² ⁹ ⁹	11.2	TNFSF11, TNFRSF11B, TNFRSF11A, BGLAP, BMP2
11	alizarin³²	9.1	ALPL, BMP2, BGLAP, ALPP, SP7
12	pyridinoline³²	9.1	TNFRSF11B, ALPP, IGFBP2, BGLAP
13	levamisole³² ⁹ ⁹	11.1	ALPL, ALPPL2, ALPP, IFNA2
14	pamidronate³² ⁹ ⁹	11.1	TNFRSF11B, BGLAP, ALPP, TNFSF11, PTH
15	25-hydroxyvitamin d³²	9.0	PTH, TNFSF11, TNFRSF11B, BGLAP, ALPP
16	titanium³²	9.0	TNFRSF11B, BMP2, BGLAP, TNFSF11, ALPP, IL11
17	pmma³²	8.9	TNFRSF11B, TNFSF11, ALPP, CD40LG
18	creatinine³²	8.8	SLC22A8, PTH, TNFRSF11B, CD40LG, PDLIM3, BMP2
19	procollagen³²	8.8	TNFSF11, BMP2, BGLAP, IGFBP2, PTH, TNFRSF11B
20	azathioprine³² ³⁴ ⁹ ⁹	11.7	BMP2, BGLAP, IL11, IGF2, IFNA2, TNFSF11
21	zoledronic acid³²	8.7	TNFRSF11B, TNFSF11, VEGFA, CTSK, BMP2, BGLAP
22	heparin³² ⁹ ¹⁸ ⁹	11.7	THPO, TNFRSF11B, ALPP, IGF2, IL11, BGLAP
23	deoxypyridinoline³²	8.6	BGLAP, IL11, IGFBP2, ALPP, TNFRSF11B, TNFSF11
24	prednisolone³² ⁹ ⁹	10.6	ALPP, IFNA2, IGFBP2, IGF2, BGLAP, TNFRSF11B
25	alendronate³² ⁹ ⁹	10.6	PTH, TNFRSF11B, ALPP, IL11, BGLAP, TNFSF11
26	steroid³²	8.5	BMP2, SLC22A8, IGFBP2, THPO, TNFRSF11B, IFNA2
27	infliximab³² ⁹ ⁹	10.5	VEGFA, TNFSF11, IFNA2, IL11, BGLAP, TNFRSF11B
28	estrogen³²	8.2	BMP2, SOST, PTH, ALPP, IGFBP2, IGF2
29	thalidomide³² ⁴² ⁹ ⁹	11.2	IL11, CD40LG, VEGFA, TNFRSF11B, IFNA2
30	polyethylene glycol³²	8.2	IFNA2, IGF2, BMP2, CD40LG, THPO, IL11
31	cycloheximide³²	8.2	PTH, IGF2, TNFSF11, TNFRSF11B, IL11, BMP2
32	hydroxyapatite³²	8.2	TNFRSF11B, BGLAP, ALPL, ALPP, TNFRSF11A, CTSK
33	indomethacin³² ⁹ ⁹	10.2	SLC22A8, IGF2, IL11, CD40LG, THPO, IFNA2
34	sb 203580³² ⁴²	9.1	BGLAP, AIRE, THPO, BMP2, VEGFA, TNFSF11
35	1,25 dihydroxy vitamin d3³²	8.1	BMP2, IL11, BGLAP, LRP5, PTH, TNFSF11
36	calcitriol³² ⁴² ⁹ ¹⁸ ⁹	11.9	BGLAP, IL11, PTH, IGF2, BMP2, TNFSF11
37	thymidine³² ¹⁸	8.8	PTH, ALPP, IFNA2, BMP2, IL11, IGF2
38	vitamin d³²	7.8	BMP2, BGLAP, IL11, IGF2, ALPL, TNFRSF11B
39	tamoxifen³² ³⁴ ⁹ ⁹	10.7	VEGFA, BGLAP, IGF2, IGFBP2, IFNA2, TNFRSF11B
40	thyroxine³² ¹⁸	8.6	IGF2, IFNA2, ALPP, TNFRSF11B, PTH, BGLAP
41	testosterone³² ⁹ ¹⁸ ⁹	10.5	SLC22A8, PTH, TNFSF11, TNFRSF11B, BGLAP, ALPP
42	ascorbic acid³² ¹⁸	8.2	IGF2, IFNA2, ALPP, TNFRSF11B, TNFSF11, SP7
43	aspartate³²	7.1	CTSK, TNFRSF11B, ALPP, IL11, BGLAP, CD40LG
44	tyrosine³²	7.0	TNFRSF11B, AIRE, IFNA2, IGF2, IL11, FOSL1
45	cysteine³²	6.6	ALPL, TNFRSF11B, BGLAP, IGF2, TNFSF11, CTSK
46	retinoic acid³² ⁴² ¹⁸	8.5	IL11, IGF2, IGFBP2, IFNA2, ALPP, TNFRSF11B
47	serine³²	6.5	BGLAP, TNFRSF11B, AIRE, ALPP, IGFBP2, IGF2
48	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	10.2	THPO, SP7, BMP2, CD40LG, TNFSF11, VEGFA
49	calcium³² ⁹ ¹⁸ ⁹	9.1	BGLAP, PDLIM3, SP7, TNFSF11, TNFRSF11B, TNFRSF11A
50	vegf³²	5.6	IGF2, IGFBP2, IFNA2, ALPP, TNFRSF11A, TNFRSF11B

GO Terms for genes affiliated with Osteosclerosis

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¹²Gene Ontology
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Cellular components related to osteosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	9.7	BMP2, BGLAP
2	extracellular region	GO:005576	6.5	LTBP3, PTH, TNFSF11, TNFRSF11B, IFNA2, IGFBP2
3	extracellular space	GO:005615	5.5	VEGFA, SOST, THPO, CTSK, PTH, TNFSF11

Biological processes related to osteosclerosis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:071848	10.1	TNFSF11, TNFRSF11A
2	TNFSF11-mediated signaling pathway	GO:071847	10.0	TNFSF11, TNFRSF11A
3	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:071812	10.0	TNFSF11, TNFRSF11A
4	bone resorption	GO:045453	10.0	TNFSF11, PTH, CTSK
5	ossification	GO:001503	9.7	SOST, TNFSF11, TNFRSF11A, IGF2
6	positive regulation of intracellular protein kinase cascade	GO:010740	9.7	VEGFA, TNFSF11
7	response to gravity	GO:009629	9.5	BGLAP, FOSL1
8	response to mechanical stimulus	GO:009612	9.3	BMP2, BGLAP, FOSL1, IGFBP2, SOST
9	osteoblast differentiation	GO:001649	9.1	BMP2, BGLAP, SP7
10	skeletal system development	GO:001501	8.9	PTH, TNFRSF11B, ALPL, IGF2, BGLAP, BMP2
11	cell-cell signaling	GO:007267	8.7	PTH, TNFRSF11A, IFNA2, IL11, BMP2
12	positive regulation of cell proliferation	GO:008284	8.6	THPO, TNFRSF11A, IGF2, IL11, FOSL1, VEGFA
13	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	PTH, TNFSF11, AIRE, IL11, BMP2, VEGFA

Molecular functions related to osteosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	alkaline phosphatase activity	GO:004035	9.2	ALPPL2, ALPP, ALPL
2	growth factor activity	GO:008083	9.1	VEGFA, BMP2, IL11, IGF2, THPO
3	cytokine activity	GO:005125	7.5	VEGFA, BMP2, CD40LG, IL11, IFNA2, TNFRSF11B