MCID: OST008
MIFTS: 35

Osteosclerotic Myeloma

Categories: Cancer diseases, Immune diseases, Blood diseases, Bone diseases

Aliases & Classifications for Osteosclerotic Myeloma

MalaCards integrated aliases for Osteosclerotic Myeloma:

Name: Osteosclerotic Myeloma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9541
SNOMED-CT 64 42215000 425657001
UMLS 69 C1510415

Summaries for Osteosclerotic Myeloma

MalaCards based summary : Osteosclerotic Myeloma is related to hypertrichosis and lymphoma. An important gene associated with Osteosclerotic Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. Affiliated tissues include b cells, skin and bone, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Osteosclerotic Myeloma

Diseases related to Osteosclerotic Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
id Related Disease Score Top Affiliating Genes
1 hypertrichosis 30.0 IL1B IL6 TNF
2 lymphoma 29.2 CD40LG CD79A IL1B IL6 TNF
3 poems syndrome 11.9
4 alcoholic neuropathy 10.8 CD40LG CD79A
5 calloso-genital dysplasia 10.8 CD40LG CD79A
6 variola major 10.8 CD40LG CD79A
7 mu chain disease 10.8 CD40LG CD79A
8 rabies 10.8 CD40LG CD79A
9 familial retinoblastoma 10.8 CD40LG CD79A
10 anti-basement membrane glomerulonephritis 10.8 CD40LG CD79A
11 microinvasive cervical squamous cell carcinoma 10.8 CD40LG CD79A
12 fetal erythroblastosis 10.8 CD40LG CD79A
13 spinal canal and spinal cord meningioma 10.8 CD40LG CD79A
14 trichostrongyloidiasis 10.8 CD40LG CD79A
15 leukodystrophy 10.8 CD40LG CD79A
16 retinal microaneurysm 10.8 CD40LG CD79A
17 heart septal defect 10.8 CD40LG CD79A
18 cryptorchidism arachnodactyly mental retardation 10.8 CD40LG CD79A
19 acute kidney tubular necrosis 10.8 CD40LG CD79A
20 secretory meningioma 10.8 CD40LG CD79A
21 hodgkin's lymphoma, nodular sclerosis 10.8 CD40LG CD79A
22 imperforate oropharynx-costo vetebral anomalies 10.8 CD40LG CD79A
23 nasopharyngeal disease 10.8 CD79A MYOM2
24 malignant otitis externa 10.8 CD40LG CD79A
25 transient hypogammaglobulinemia 10.8 CD40LG CD79A
26 benign epilepsy with centrotemporal spikes 10.8 CD40LG CD79A
27 tongue cancer 10.8 CD40LG CD79A
28 hydrops of gallbladder 10.8 CD40LG CD79A
29 cannabis dependence 10.8 CD40LG MAG
30 gamma heavy chain disease 10.8 CD40LG CD79A
31 diabetic angiopathy 10.8 CD40LG CD79A
32 rosacea conjunctivitis 10.7 CD40LG CD79A
33 viral meningitis 10.7 CD40LG CD79A
34 heart fibrosarcoma 10.7 CD40LG CD79A
35 alopecia areata 10.7 CD40LG CD79A
36 kidney carcinoma in situ 10.7 CD40LG CD79A
37 toxic optic neuropathy 10.7 CD79A IL1B
38 cardiac tuberculosis 10.7 CD40LG CD79A
39 dumping syndrome 10.7 CD40LG CD79A
40 leiomyosarcoma 10.7 CD40LG CD79A
41 periarthritis 10.7 CD40LG CD79A
42 cerebral neuroblastoma 10.7 CD40LG CD79A
43 pancreatic vasoactive intestinal peptide producing tumor 10.7 CD40LG CD79A
44 oculo-cerebral dysplasia 10.7 CD40LG CD79A
45 aniseikonia 10.7 CD40LG CD79A
46 gestational diabetes 10.7 CD40LG CD79A
47 oculomotor nerve paralysis 10.6 IL1B IL6
48 polyneuropathy due to drug 10.6 CD40LG CD79A
49 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
50 chronic mucocutaneous candidiasis 10.6 CD40LG CD79A

Graphical network of the top 20 diseases related to Osteosclerotic Myeloma:



Diseases related to Osteosclerotic Myeloma

Symptoms & Phenotypes for Osteosclerotic Myeloma

MGI Mouse Phenotypes related to Osteosclerotic Myeloma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 TNF IL1RN VWF IL6 CD40LG PDGFC
2 hematopoietic system MP:0005397 9.97 VWF IL6 MAG CD40LG CD79A PLG
3 homeostasis/metabolism MP:0005376 9.96 IL1RN VWF IL6 MAG CD40LG PDGFC
4 immune system MP:0005387 9.81 IL1RN VWF IL6 MAG CD40LG CD79A
5 integument MP:0010771 9.5 TNF IL1RN IL6 CD40LG PDGFC PLG
6 nervous system MP:0003631 9.28 VWF IL6 MAG CD40LG PDGFC CD79A

Drugs & Therapeutics for Osteosclerotic Myeloma

Search Clinical Trials , NIH Clinical Center for Osteosclerotic Myeloma

Genetic Tests for Osteosclerotic Myeloma

Anatomical Context for Osteosclerotic Myeloma

MalaCards organs/tissues related to Osteosclerotic Myeloma:

39
B Cells, Skin, Bone

Publications for Osteosclerotic Myeloma

Articles related to Osteosclerotic Myeloma:

(show all 37)
id Title Authors Year
1
Autoimmune haemolytic anaemia and neuropathy with IgA osteosclerotic myeloma: a case report. ( 28826828 )
2017
2
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. ( 27365880 )
2016
3
Circulating plasma cells with Russell bodies in osteosclerotic myeloma. ( 24006527 )
2013
4
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. ( 23671753 )
2013
5
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. ( 22611150 )
2012
6
Osteosclerotic myeloma with POEMS syndrome. ( 20047930 )
2010
7
Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report. ( 16845298 )
2006
8
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. ( 19078779 )
2005
9
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. ( 15884463 )
2004
10
CIDP and isolated osteosclerotic myeloma. ( 15623724 )
2004
11
Clinical images: Osteosclerotic myeloma associated with the POEMS syndrome. ( 12124883 )
2002
12
Strontium-89: a novel treatment for a case of osteosclerotic myeloma associated with life-threatening neuropathy. ( 12181052 )
2002
13
Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy. ( 9667789 )
1998
14
Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy. ( 9236797 )
1997
15
Multiple myeloma associated with diffuse osteosclerotic bone lesions: a clinical entity distinct from osteosclerotic myeloma (POEMS syndrome). ( 9395194 )
1997
16
Osteosclerotic myeloma and 'POEMS' syndrome. ( 8813338 )
1996
17
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. A case report. ( 1541970 )
1992
18
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. ( 1953537 )
1991
19
Osteosclerotic myeloma with polyneuropathy and hypocalcemia. ( 2539870 )
1989
20
Case report 572. Osteosclerotic myeloma (POEMS) syndrome. ( 2588035 )
1989
21
Osteosclerotic myeloma variants. ( 3363376 )
1988
22
Successful treatment of peripheral neuropathy with chemotherapy in osteosclerotic myeloma. ( 3039073 )
1987
23
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis. ( 3920544 )
1985
24
Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. ( 2993255 )
1985
25
'Incomplete' pyroglobulin-gamma disease in a patient with osteosclerotic myeloma. ( 6438794 )
1984
26
Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy. ( 6325905 )
1984
27
Osteosclerotic myeloma and peripheral neuropathy. ( 6296727 )
1983
28
Melphalan-induced pulmonary fibrosis in osteosclerotic myeloma. ( 6404091 )
1983
29
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. ( 6858968 )
1983
30
Osteosclerotic myeloma with polyneuropathy. ( 6254342 )
1980
31
Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin. ( 203470 )
1978
32
Osteosclerotic myeloma (a case report and review of literature). ( 680785 )
1978
33
Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. ( 559975 )
1977
34
Osteosclerotic myeloma. ( 184307 )
1976
35
Osteosclerotic myeloma with peripheral neuropathy. ( 4371433 )
1974
36
Osteosclerotic myeloma and peripheral neuropathy. A case report. ( 4329504 )
1971
37
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Osteosclerotic Myeloma

Expression for Osteosclerotic Myeloma

Search GEO for disease gene expression data for Osteosclerotic Myeloma.

Pathways for Osteosclerotic Myeloma

Pathways related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 39)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD40LG IL1B IL1RN IL6 TNF VWF
2
Show member pathways
12.56 CD40LG IL1B PDGFC TNF
3
Show member pathways
12.54 CD40LG IL1B IL6 PDGFC TNF
4
Show member pathways
12.48 IL1B IL6 PLG TNF
5
Show member pathways
12.31 CD40LG IL1B IL6 TNF
6 12.22 CD40LG CD79A IL1B IL1RN TNF
7
Show member pathways
12.06 IL1B IL6 TNF
8 12.01 IL1B IL1RN IL6 TNF
9 12 A2M PLG VWF
10 11.9 CD79A IL6 TNF
11 11.89 IL1B IL6 TNF
12 11.86 IL1B IL6 TNF
13
Show member pathways
11.85 IL1B IL6 TNF
14 11.81 IL1B IL6 TNF
15
Show member pathways
11.8 A2M PLG TNF
16 11.79 IL1B IL6 TNF
17 11.78 IL1B IL6 TNF
18 11.77 CD40LG IL1B TNF
19 11.74 IL1B IL6 TNF
20 11.65 IL1B IL6 TNF
21 11.64 IL1B IL6 TNF
22 11.64 IL1B IL6 MAG TNF
23 11.6 CD40LG IL6 TNF
24 11.54 IL1B IL6 TNF
25 11.47 IL1B IL6 TNF
26 11.39 IL6 PLG TNF
27 11.34 IL1B IL6 TNF
28
Show member pathways
11.26 CD40LG IL1B IL6 TNF
29 11.2 IL1B IL6 TNF
30 11.18 IL1B IL6 TNF
31 11.11 IL1B IL6 TNF
32 11.08 CD40LG IL1B IL6 TNF
33 11.07 IL1B IL6 TNF
34 11.02 IL1B IL6 TNF
35 10.95 IL6 TNF
36 10.95 IL1B IL1RN IL6 TNF
37 10.87 IL1B TNF
38 10.8 IL1B IL6
39 10.61 CD40LG IL1B IL6 TNF

GO Terms for Osteosclerotic Myeloma

Cellular components related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.56 CD40LG CD79A IL6 TNF
2 extracellular space GO:0005615 9.56 A2M CD40LG IL1B IL1RN IL6 PDGFC
3 platelet alpha granule lumen GO:0031093 9.33 A2M PLG VWF
4 extracellular region GO:0005576 9.28 A2M CD40LG IL1B IL1RN IL6 PDGFC

Biological processes related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CD40LG IL1B IL1RN IL6 TNF
2 platelet degranulation GO:0002576 9.79 A2M PLG VWF
3 platelet activation GO:0030168 9.77 CD40LG IL6 VWF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.77 IL1B IL6 TNF
5 response to glucocorticoid GO:0051384 9.72 IL1RN IL6 TNF
6 positive regulation of T cell proliferation GO:0042102 9.7 CD40LG IL1B IL6
7 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
8 blood coagulation, intrinsic pathway GO:0007597 9.63 A2M VWF
9 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
10 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
14 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6 TNF
15 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
16 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
17 inflammatory response GO:0006954 9.55 CD40LG IL1B IL1RN IL6 TNF
18 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
19 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.51 IL6 TNF
20 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
21 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 IL1B IL6 TNF
23 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
24 muscle cell cellular homeostasis GO:0046716 9.33 IL6
25 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
26 fever generation GO:0001660 9.18 IL1B
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF
28 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 CD40LG IL1B IL6 TNF

Molecular functions related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.56 A2M IL6 MAG PLG
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 protease binding GO:0002020 9.13 A2M TNF VWF
4 cytokine activity GO:0005125 9.02 CD40LG IL1B IL1RN IL6 TNF

Sources for Osteosclerotic Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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