MCID: OST008
MIFTS: 38

Osteosclerotic Myeloma

Categories: Bone diseases, Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Osteosclerotic Myeloma

MalaCards integrated aliases for Osteosclerotic Myeloma:

Name: Osteosclerotic Myeloma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9541
SNOMED-CT 64 42215000 425657001
UMLS 69 C1510415

Summaries for Osteosclerotic Myeloma

MalaCards based summary : Osteosclerotic Myeloma is related to poems syndrome and chronic polyneuropathy. An important gene associated with Osteosclerotic Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. Affiliated tissues include b cells, skin and bone, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Osteosclerotic Myeloma

Diseases related to Osteosclerotic Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 33.1 IL1B IL6 MYOM2 TNF
2 chronic polyneuropathy 30.1 CD40LG CD79A MAG MYOM2
3 myeloma, multiple 30.0 CD40LG CD79A IL6 MYOM2
4 selective igg deficiency disease 10.6 CD40LG CD79A
5 c1q nephropathy 10.6 CD40LG CD79A
6 meningovascular neurosyphilis 10.6 CD40LG CD79A
7 alpha chain disease 10.6 CD40LG CD79A
8 brill-zinsser disease 10.5 CD40LG CD79A
9 exudative glomerulonephritis 10.5 CD40LG CD79A
10 cork-handlers' disease 10.5 CD40LG CD79A
11 salpingo-oophoritis 10.5 CD40LG CD79A
12 early yaws 10.5 CD40LG CD79A
13 ventilation pneumonitis 10.5 CD40LG CD79A
14 chronic interstitial cystitis 10.5 CD40LG CD79A
15 axillary adenitis 10.5 CD40LG CD79A
16 cryofibrinogenemia 10.5 CD40LG CD79A
17 trichostrongyloidiasis 10.5 CD40LG CD79A
18 subacute bacterial endocarditis 10.5 CD40LG CD79A
19 heterophyiasis 10.5 CD40LG CD79A
20 immunoglobulin g deficiency 10.5 CD40LG CD79A
21 orbital granuloma 10.5 CD40LG CD79A
22 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
23 hyperglobulinemic purpura 10.5 CD40LG CD79A
24 gastroduodenitis 10.5 CD40LG CD79A
25 bacterial conjunctivitis 10.5 CD40LG CD79A
26 heavy chain disease 10.5 CD40LG CD79A
27 ophthalmia neonatorum 10.5 CD40LG CD79A
28 mononeuritis multiplex 10.5 CD40LG MAG
29 immunoglobulin a deficiency 1 10.5 CD40LG CD79A
30 parotid disease 10.5 CD40LG CD79A
31 smoldering myeloma 10.5 CD79A MYOM2
32 selective immunoglobulin deficiency disease 10.5 CD40LG CD79A
33 geniculate herpes zoster 10.5 CD40LG CD79A
34 chronic follicular conjunctivitis 10.5 CD79A IL1B
35 erythema elevatum diutinum 10.5 CD40LG CD79A
36 sporotrichosis 10.5 CD40LG CD79A
37 fallopian tube disease 10.5 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.5 CD40LG CD79A
39 congenital syphilis 10.4 CD40LG CD79A
40 salpingitis 10.4 CD40LG CD79A
41 ocular toxoplasmosis 10.4 CD40LG CD79A
42 recurrent corneal erosion 10.4 IL1B IL6
43 scorpion envenomation 10.4 IL6 TNF
44 parasitic ichthyosporea infectious disease 10.4 CD40LG CD79A
45 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG MAG MYOM2
46 bagassosis 10.4 IL1B IL6
47 dysgammaglobulinemia 10.4 CD40LG CD79A
48 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
49 polyposis, gastric 10.4 IL1B TNF
50 acute maxillary sinusitis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Osteosclerotic Myeloma:



Diseases related to Osteosclerotic Myeloma

Symptoms & Phenotypes for Osteosclerotic Myeloma

MGI Mouse Phenotypes related to Osteosclerotic Myeloma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 PLG IL1B TNF IL1RN VWF IL6
2 hematopoietic system MP:0005397 9.97 CD79A PLG IL1B TNF IL1RN VWF
3 homeostasis/metabolism MP:0005376 9.96 CD79A PLG IL1B TNF IL1RN VWF
4 immune system MP:0005387 9.81 CD79A PLG IL1B TNF IL1RN VWF
5 integument MP:0010771 9.5 CD40LG PDGFC PLG IL1B TNF IL1RN
6 nervous system MP:0003631 9.28 CD79A PLG IL1B TNF VWF IL6

Drugs & Therapeutics for Osteosclerotic Myeloma

Search Clinical Trials , NIH Clinical Center for Osteosclerotic Myeloma

Genetic Tests for Osteosclerotic Myeloma

Anatomical Context for Osteosclerotic Myeloma

MalaCards organs/tissues related to Osteosclerotic Myeloma:

38
B Cells, Skin, Bone

Publications for Osteosclerotic Myeloma

Articles related to Osteosclerotic Myeloma:

(show all 37)
# Title Authors Year
1
Autoimmune haemolytic anaemia and neuropathy with IgA osteosclerotic myeloma: a case report. ( 28826828 )
2017
2
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. ( 27365880 )
2016
3
Circulating plasma cells with Russell bodies in osteosclerotic myeloma. ( 24006527 )
2013
4
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. ( 23671753 )
2013
5
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. ( 22611150 )
2012
6
Osteosclerotic myeloma with POEMS syndrome. ( 20047930 )
2010
7
Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report. ( 16845298 )
2006
8
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. ( 19078779 )
2005
9
CIDP and isolated osteosclerotic myeloma. ( 15623724 )
2004
10
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. ( 15884463 )
2004
11
Strontium-89: a novel treatment for a case of osteosclerotic myeloma associated with life-threatening neuropathy. ( 12181052 )
2002
12
Clinical images: Osteosclerotic myeloma associated with the POEMS syndrome. ( 12124883 )
2002
13
Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy. ( 9667789 )
1998
14
Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy. ( 9236797 )
1997
15
Multiple myeloma associated with diffuse osteosclerotic bone lesions: a clinical entity distinct from osteosclerotic myeloma (POEMS syndrome). ( 9395194 )
1997
16
Osteosclerotic myeloma and 'POEMS' syndrome. ( 8813338 )
1996
17
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. A case report. ( 1541970 )
1992
18
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. ( 1953537 )
1991
19
Osteosclerotic myeloma with polyneuropathy and hypocalcemia. ( 2539870 )
1989
20
Case report 572. Osteosclerotic myeloma (POEMS) syndrome. ( 2588035 )
1989
21
Osteosclerotic myeloma variants. ( 3363376 )
1988
22
Successful treatment of peripheral neuropathy with chemotherapy in osteosclerotic myeloma. ( 3039073 )
1987
23
Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. ( 2993255 )
1985
24
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis. ( 3920544 )
1985
25
Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy. ( 6325905 )
1984
26
'Incomplete' pyroglobulin-gamma disease in a patient with osteosclerotic myeloma. ( 6438794 )
1984
27
Melphalan-induced pulmonary fibrosis in osteosclerotic myeloma. ( 6404091 )
1983
28
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. ( 6858968 )
1983
29
Osteosclerotic myeloma and peripheral neuropathy. ( 6296727 )
1983
30
Osteosclerotic myeloma with polyneuropathy. ( 6254342 )
1980
31
Osteosclerotic myeloma (a case report and review of literature). ( 680785 )
1978
32
Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin. ( 203470 )
1978
33
Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. ( 559975 )
1977
34
Osteosclerotic myeloma. ( 184307 )
1976
35
Osteosclerotic myeloma with peripheral neuropathy. ( 4371433 )
1974
36
Osteosclerotic myeloma and peripheral neuropathy. A case report. ( 4329504 )
1971
37
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Osteosclerotic Myeloma

Expression for Osteosclerotic Myeloma

Search GEO for disease gene expression data for Osteosclerotic Myeloma.

Pathways for Osteosclerotic Myeloma

Pathways related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD40LG IL1B IL1RN IL6 TNF VWF
2
Show member pathways
12.57 CD40LG IL1B PDGFC TNF
3
Show member pathways
12.53 CD40LG IL1B IL6 PDGFC TNF
4
Show member pathways
12.49 IL1B IL6 PLG TNF
5
Show member pathways
12.32 CD40LG IL1B IL6 TNF
6 12.23 CD40LG CD79A IL1B IL1RN TNF
7
Show member pathways
12.2 IL1B IL6 PLG TNF
8
Show member pathways
12.06 IL1B IL6 TNF
9 12.01 IL1B IL1RN IL6 TNF
10 12 A2M PLG VWF
11 11.91 CD79A IL6 TNF
12 11.9 IL1B IL6 TNF
13 11.86 IL1B IL6 TNF
14
Show member pathways
11.84 IL1B IL6 TNF
15 11.82 IL1B IL6 TNF
16
Show member pathways
11.81 A2M PLG TNF
17 11.8 IL1B IL6 TNF
18 11.79 IL1B IL6 TNF
19 11.78 CD40LG IL1B TNF
20 11.75 IL1B IL6 TNF
21 11.66 IL1B IL6 TNF
22 11.64 IL1B IL6 TNF
23 11.64 IL1B IL6 MAG TNF
24 11.58 CD40LG IL6 TNF
25 11.55 IL1B IL6 TNF
26 11.47 IL1B IL6 TNF
27 11.39 IL6 PLG TNF
28 11.35 IL1B IL6 TNF
29
Show member pathways
11.26 CD40LG IL1B IL6 TNF
30 11.2 IL1B IL6 TNF
31 11.18 IL1B IL6 TNF
32 11.11 IL1B IL6 TNF
33 11.08 CD40LG IL1B IL6 TNF
34 11.07 IL1B IL6 TNF
35 11.02 IL1B IL6 TNF
36 10.96 IL6 TNF
37 10.95 IL1B IL1RN IL6 TNF
38 10.89 CD40LG IL1B IL6 PDGFC TNF
39 10.88 IL1B TNF
40 10.72 IL1B IL6
41 10.61 CD40LG IL1B IL6 TNF

GO Terms for Osteosclerotic Myeloma

Cellular components related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 A2M CD40LG IL1B IL1RN IL6 PDGFC
2 platelet alpha granule lumen GO:0031093 9.33 A2M PLG VWF
3 extracellular region GO:0005576 9.28 A2M CD40LG IL1B IL1RN IL6 PDGFC

Biological processes related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CD40LG IL1B IL1RN IL6 TNF
2 platelet degranulation GO:0002576 9.78 A2M PLG VWF
3 platelet activation GO:0030168 9.77 CD40LG IL6 VWF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.75 IL1B IL6 TNF
5 response to glucocorticoid GO:0051384 9.7 IL1RN IL6 TNF
6 positive regulation of T cell proliferation GO:0042102 9.69 CD40LG IL1B IL6
7 inflammatory response GO:0006954 9.65 CD40LG IL1B IL1RN IL6 TNF
8 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
9 blood coagulation, intrinsic pathway GO:0007597 9.62 A2M VWF
10 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
13 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL1B TNF
15 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
16 positive regulation of chemokine biosynthetic process GO:0045080 9.55 IL1B TNF
17 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
18 fever generation GO:0001660 9.48 IL1B IL1RN
19 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
20 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
21 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
22 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 CD40LG IL1B IL6 TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
25 regulation of receptor activity GO:0010469 9.1 CD40LG IL1B IL1RN IL6 PDGFC TNF

Molecular functions related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
2 protease binding GO:0002020 9.13 A2M TNF VWF
3 cytokine activity GO:0005125 9.02 CD40LG IL1B IL1RN IL6 TNF

Sources for Osteosclerotic Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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