MCID: OST008
MIFTS: 36

Osteosclerotic Myeloma malady

Categories: Cancer diseases, Immune diseases, Blood diseases, Bone diseases

Aliases & Classifications for Osteosclerotic Myeloma

Aliases & Descriptions for Osteosclerotic Myeloma:

Name: Osteosclerotic Myeloma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9541
SNOMED-CT 64 42215000 425657001
UMLS 69 C1510415

Summaries for Osteosclerotic Myeloma

MalaCards based summary : Osteosclerotic Myeloma is related to neuropathy and poems syndrome. An important gene associated with Osteosclerotic Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. Affiliated tissues include bone, skin and b cells, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Osteosclerotic Myeloma

Diseases related to Osteosclerotic Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
id Related Disease Score Top Affiliating Genes
1 neuropathy 30.4 IL1B IL6 TNF
2 poems syndrome 11.6
3 alcoholic neuropathy 10.3 CD40LG CD79A
4 camptodactyly vertebral fusion 10.3 CD40LG CD79A
5 spinal polio 10.3 CD40LG CD79A
6 rabies 10.3 CD40LG CD79A
7 unilateral retinoblastoma 10.3 CD40LG CD79A
8 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
9 delta chain disease 10.3 CD40LG CD79A
10 discitis 10.3 CD40LG CD79A
11 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
12 trichostrongyloidiasis 10.3 CD40LG CD79A
13 colloid adenoma 10.3 CD40LG CD79A
14 heart septal defect 10.3 CD40LG CD79A
15 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
16 mild pre-eclampsia 10.3 CD40LG CD79A
17 retinal microaneurysm 10.3 CD40LG CD79A
18 pediatric meningioma 10.3 CD40LG CD79A
19 tonsil cancer 10.3 CD40LG CD79A
20 indomethacin antenatal infection 10.3 CD40LG CD79A
21 postcricoid region cancer 10.3 CD40LG CD79A
22 beach ear 10.3 CD40LG CD79A
23 acute kidney tubular necrosis 10.3 CD40LG CD79A
24 toxic optic neuropathy 10.3 CD79A IL1B
25 polyneuropathy 10.3
26 jaw cancer 10.3 CD40LG MAG MYOM2
27 cannabis dependence 10.3 CD40LG MAG MYOM2
28 nerve compression syndrome 10.3 CD40LG MAG MYOM2
29 atheroembolism of kidney 10.3 CD40LG CD79A
30 intussusception 10.3 IL1B TNF
31 partial sensory epilepsy 10.3 CD40LG CD79A
32 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
33 venezuelan equine encephalitis 10.3 CD40LG CD79A MYOM2
34 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
35 diabetic angiopathy 10.2 CD40LG CD79A
36 oculomotor nerve paralysis 10.2 IL1B IL6
37 common peroneal nerve lesion 10.2 IL1B IL6
38 retinal degeneration 10.2 CD40LG CD79A IL6
39 lateral cystocele 10.2 CD40LG CD79A IL6
40 endocarditis 10.2 CD40LG CD79A
41 tau syndrome 10.2 IL1B TNF
42 dyslexia 5 10.2 IL6 TNF
43 muscular dystrophy 10.2 CD40LG CD79A
44 submandibular gland disease 10.2 CD40LG MAG TNF
45 aortic atherosclerosis 10.2 IL6 TNF
46 white piedra 10.2 CD40LG CD79A MAG
47 functional gastric disease 10.2 CD40LG MYOM2 TNF
48 hemangioma of orbit 10.2 CD40LG CD79A TNF
49 endogenous depression 10.2 CD40LG MYOM2 TNF
50 uveitis 10.2 CD40LG CD79A TNF

Graphical network of the top 20 diseases related to Osteosclerotic Myeloma:



Diseases related to Osteosclerotic Myeloma

Symptoms & Phenotypes for Osteosclerotic Myeloma

MGI Mouse Phenotypes related to Osteosclerotic Myeloma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CD40LG IL1B IL1RN IL6 PDGFC PLG
2 hematopoietic system MP:0005397 9.97 TNF VWF CD40LG CD79A IL1B IL1RN
3 homeostasis/metabolism MP:0005376 9.96 VWF CD40LG CD79A IL1B IL1RN IL6
4 immune system MP:0005387 9.81 CD40LG CD79A IL1B IL1RN IL6 MAG
5 integument MP:0010771 9.5 CD40LG IL1B IL1RN IL6 PDGFC PLG
6 nervous system MP:0003631 9.28 CD40LG CD79A IL1B IL6 MAG PDGFC

Drugs & Therapeutics for Osteosclerotic Myeloma

Search Clinical Trials , NIH Clinical Center for Osteosclerotic Myeloma

Genetic Tests for Osteosclerotic Myeloma

Anatomical Context for Osteosclerotic Myeloma

MalaCards organs/tissues related to Osteosclerotic Myeloma:

39
Bone, Skin, B Cells

Publications for Osteosclerotic Myeloma

Articles related to Osteosclerotic Myeloma:

(show all 36)
id Title Authors Year
1
Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome. ( 27365880 )
2016
2
Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma. ( 23671753 )
2013
3
Circulating plasma cells with Russell bodies in osteosclerotic myeloma. ( 24006527 )
2013
4
Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. ( 22611150 )
2012
5
Osteosclerotic myeloma with POEMS syndrome. ( 20047930 )
2010
6
Osteosclerotic myeloma with spinal leptomeningitis and severe polyneuropathy: A case report. ( 16845298 )
2006
7
Polyneuropathy in Osteosclerotic Myeloma Coexisting With Hyaline Vascular Castleman's Disease. ( 19078779 )
2005
8
CIDP and isolated osteosclerotic myeloma. ( 15623724 )
2004
9
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. ( 15884463 )
2004
10
Strontium-89: a novel treatment for a case of osteosclerotic myeloma associated with life-threatening neuropathy. ( 12181052 )
2002
11
Clinical images: Osteosclerotic myeloma associated with the POEMS syndrome. ( 12124883 )
2002
12
Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy. ( 9667789 )
1998
13
Multiple myeloma associated with diffuse osteosclerotic bone lesions: a clinical entity distinct from osteosclerotic myeloma (POEMS syndrome). ( 9395194 )
1997
14
Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy. ( 9236797 )
1997
15
Osteosclerotic myeloma and 'POEMS' syndrome. ( 8813338 )
1996
16
Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. A case report. ( 1541970 )
1992
17
POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report. ( 1953537 )
1991
18
Osteosclerotic myeloma with polyneuropathy and hypocalcemia. ( 2539870 )
1989
19
Case report 572. Osteosclerotic myeloma (POEMS) syndrome. ( 2588035 )
1989
20
Osteosclerotic myeloma variants. ( 3363376 )
1988
21
Successful treatment of peripheral neuropathy with chemotherapy in osteosclerotic myeloma. ( 3039073 )
1987
22
Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome. ( 2993255 )
1985
23
Osteosclerotic myeloma complicated by diffuse arteritis, vascular calcification and extensive cutaneous necrosis. ( 3920544 )
1985
24
'Incomplete' pyroglobulin-gamma disease in a patient with osteosclerotic myeloma. ( 6438794 )
1984
25
Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy. ( 6325905 )
1984
26
Melphalan-induced pulmonary fibrosis in osteosclerotic myeloma. ( 6404091 )
1983
27
Diffuse nonsecretory osteosclerotic myeloma with extensive erythrophagocytosis. ( 6858968 )
1983
28
Osteosclerotic myeloma and peripheral neuropathy. ( 6296727 )
1983
29
Osteosclerotic myeloma with polyneuropathy. ( 6254342 )
1980
30
Osteosclerotic myeloma (a case report and review of literature). ( 680785 )
1978
31
Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin. ( 203470 )
1978
32
Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. ( 559975 )
1977
33
Osteosclerotic myeloma. ( 184307 )
1976
34
Osteosclerotic myeloma with peripheral neuropathy. ( 4371433 )
1974
35
Osteosclerotic myeloma and peripheral neuropathy. A case report. ( 4329504 )
1971
36
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Osteosclerotic Myeloma

Expression for Osteosclerotic Myeloma

Search GEO for disease gene expression data for Osteosclerotic Myeloma.

Pathways for Osteosclerotic Myeloma

Pathways related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD40LG IL1B IL1RN IL6 TNF VWF
2
Show member pathways
12.57 CD40LG IL1B PDGFC TNF
3
Show member pathways
12.54 CD40LG IL1B IL6 PDGFC TNF
4
Show member pathways
12.48 IL1B IL6 PLG TNF
5
Show member pathways
12.32 CD40LG IL1B IL6 TNF
6 12.22 CD40LG CD79A IL1B IL1RN TNF
7
Show member pathways
12.2 IL1B IL6 PLG TNF
8
Show member pathways
12.06 IL1B IL6 TNF
9 12.01 IL1B IL1RN IL6 TNF
10 12 A2M PLG VWF
11 11.91 CD79A IL6 TNF
12 11.89 IL1B IL6 TNF
13 11.86 IL1B IL6 TNF
14
Show member pathways
11.85 IL1B IL6 TNF
15 11.81 IL1B IL6 TNF
16
Show member pathways
11.8 A2M PLG TNF
17 11.79 IL1B IL6 TNF
18 11.78 IL1B IL6 TNF
19 11.77 CD40LG IL1B TNF
20 11.74 IL1B IL6 TNF
21 11.66 IL1B IL6 TNF
22 11.65 IL1B IL6 TNF
23 11.64 IL1B IL6 MAG TNF
24 11.61 CD40LG IL6 TNF
25 11.55 IL1B IL6 TNF
26 11.47 IL1B IL6 TNF
27 11.39 IL6 PLG TNF
28 11.34 IL1B IL6 TNF
29
Show member pathways
11.26 CD40LG IL1B IL6 TNF
30 11.2 IL1B IL6 TNF
31 11.18 IL1B IL6 TNF
32 11.11 IL1B IL6 TNF
33 11.08 CD40LG IL1B IL6 TNF
34 11.07 IL1B IL6 TNF
35 11.02 IL1B IL6 TNF
36 10.96 IL6 TNF
37 10.95 IL1B IL1RN IL6 TNF
38 10.87 IL1B TNF
39 10.83 IL1B IL6
40 10.61 CD40LG IL1B IL6 TNF

GO Terms for Osteosclerotic Myeloma

Cellular components related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 A2M CD40LG IL1B IL1RN IL6 PDGFC
2 external side of plasma membrane GO:0009897 9.56 CD40LG CD79A IL6 TNF
3 platelet alpha granule lumen GO:0031093 9.33 A2M PLG VWF
4 extracellular space GO:0005615 9.23 A2M CD40LG IL1B IL1RN IL6 PDGFC

Biological processes related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 CD40LG IL1B IL1RN IL6 TNF
2 platelet degranulation GO:0002576 9.79 A2M PLG VWF
3 platelet activation GO:0030168 9.77 CD40LG IL6 VWF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.75 IL1B IL6 TNF
5 response to glucocorticoid GO:0051384 9.71 IL1RN IL6 TNF
6 positive regulation of T cell proliferation GO:0042102 9.69 CD40LG IL1B IL6
7 positive regulation of NF-kappaB import into nucleus GO:0042346 9.63 IL1B TNF
8 blood coagulation, intrinsic pathway GO:0007597 9.62 A2M VWF
9 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
10 positive regulation of chemokine production GO:0032722 9.61 IL6 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL1B TNF
14 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
15 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
16 inflammatory response GO:0006954 9.55 CD40LG IL1B IL1RN IL6 TNF
17 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
18 positive regulation of interleukin-6 production GO:0032755 9.5 IL1B IL6 TNF
19 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.49 IL6 TNF
20 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
21 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 IL1B IL6 TNF
23 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
24 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.37 IL1RN IL6
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 CD40LG IL1B IL6 TNF

Molecular functions related to Osteosclerotic Myeloma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.56 A2M IL6 MAG PLG
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 protease binding GO:0002020 9.13 A2M TNF VWF
4 cytokine activity GO:0005125 9.02 CD40LG IL1B IL1RN IL6 TNF

Sources for Osteosclerotic Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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