MCID: OTT001
MIFTS: 47

Otitis Externa malady

Categories: Ear diseases

Aliases & Classifications for Otitis Externa

Aliases & Descriptions for Otitis Externa:

Name: Otitis Externa 12 42 14 69
Acute Infective Otitis Externa 69
Infective Otitis Externa 69
Swimmer's Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9463
ICD9CM 35 380.1 380.10
MeSH 42 D010032
NCIt 47 C3299
ICD10 33 H60 H62.4
UMLS 69 C0021355

Summaries for Otitis Externa

Disease Ontology : 12 An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections.

MalaCards based summary : Otitis Externa, also known as acute infective otitis externa, is related to mastoiditis and malignant otitis externa. An important gene associated with Otitis Externa is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are TCR Signaling (Qiagen) and NF-KappaB Family Pathway. The drugs Cipro and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes.

Wikipedia : 71 Otitis externa, also known as swimmer\'s ear, is an inflammation of the ear canal. It often presents... more...

Related Diseases for Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Related Disease Score Top Affiliating Genes
1 mastoiditis 29.9 CALM1 CALM2 CALM3 ELANE
2 malignant otitis externa 12.6
3 chronic fungal otitis externa 12.2
4 beach ear 11.6
5 otomycosis 11.3
6 acute infection of pinna 11.0
7 perichondritis of auricle 11.0
8 otitis media 10.4
9 cholesteatoma of external ear 10.2
10 osteomyelitis 10.2
11 dermatitis 10.1
12 pyoderma 10.1
13 encephalomalacia 10.0 CALM1 CALM3
14 cervicitis 10.0
15 contact dermatitis 10.0
16 histiocytosis 10.0
17 bleeding disorder, platelet-type, 15 10.0 CALM1 CALM2 CALM3
18 microphthalmia with limb anomalies 10.0 CALM1 CALM2 CALM3
19 subclavian steal syndrome 10.0 CALM1 CALM2 CALM3
20 leukemia, acute lymphoblastic 2 10.0 CALM1 CALM2 CALM3
21 short stature with microcephaly and distinctive facies 9.9 CALM1 CALM2 CALM3
22 neuropathy, hereditary sensory and autonomic, type ii 9.9 CALM1 CALM2 CALM3
23 dumping syndrome 9.9 CALM1 CALM2 CALM3
24 retinitis pigmentosa 20 9.9 CALM1 CALM2 CALM3
25 allergic contact dermatitis 9.9
26 suppurative otitis media 9.9
27 arthritis 9.9
28 leukemia 9.9
29 cranial nerve palsy 9.9
30 squamous cell carcinoma 9.9
31 pneumonia 9.9
32 septic arthritis 9.9
33 regular astigmatism 9.9 CALM1 CALM2 CALM3
34 aspiration pneumonia 9.9 CALM1 CALM2 CALM3
35 familial sick sinus syndrome 9.9 CALM1 CALM2 CALM3
36 lipodystrophy, familial partial, 2 9.9 CALM1 CALM2 CALM3
37 ciliary dyskinesia, primary, 11 9.9 CALM1 CALM2 CALM3
38 deafness, autosomal dominant 2a 9.9 CALM1 CALM2 CALM3
39 congenital hypothyroidism 9.9 CALM1 CALM2 CALM3
40 distal arthrogryposis 9.9 CALM1 CALM2 CALM3
41 partial of retinal vein occlusion 9.9 CALM1 CALM2 CALM3
42 neurofibroma 9.8 CALM1 CALM2 CALM3
43 autosomal dominant nocturnal frontal lobe epilepsy 2 9.8 CALM1 CALM2 CALM3
44 cholesteatoma 9.8
45 leishmaniasis 9.8
46 meningoencephalitis 9.8
47 adenocarcinoma 9.8
48 candida glabrata 9.8
49 lemierre's syndrome 9.8
50 demodicidosis 9.8

Comorbidity relations with Otitis Externa via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Hypertension, Essential Ischemic Heart Disease
Otitis Media

Graphical network of the top 20 diseases related to Otitis Externa:



Diseases related to Otitis Externa

Symptoms & Phenotypes for Otitis Externa

Drugs & Therapeutics for Otitis Externa

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cipro 17 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer Approved June 1997

Drugs for Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
2
Ciprofloxacin Approved, Investigational Phase 3,Phase 2,Phase 1 85721-33-1 2764
3
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
4
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
5
Norgestimate Approved Phase 3 35189-28-7 6540478
6
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
7
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
8
Dipivefrin Approved Phase 3,Phase 2,Phase 1 52365-63-6 3105
9
Povidone-iodine Approved Phase 3 25655-41-8
10
Butyric Acid Experimental Phase 3 107-92-6 264
11 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
12 glucocorticoids Phase 3,Phase 2
13
protease inhibitors Phase 3,Phase 2
14 Gastrointestinal Agents Phase 3,Phase 2
15 HIV Protease Inhibitors Phase 3,Phase 2
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Phase 2,Phase 1
17 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
19 Hormone Antagonists Phase 3,Phase 2
20 Dexamethasone 21-phosphate Phase 3,Phase 2
21 Hormones Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 3,Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
24 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
25 Anti-Infective Agents Phase 3,Phase 2,Phase 1
26 Antiemetics Phase 3,Phase 2
27 Anti-Inflammatory Agents Phase 3,Phase 2
28 BB 1101 Phase 3,Phase 2
29 Autonomic Agents Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 3,Phase 2
31
Iodine Phase 3 7553-56-2 807
32 cadexomer iodine Phase 3
33 Estradiol valerate Phase 3 979-32-8
34 Ciprofloxacin, hydrocortisone drug combination Phase 3
35 Contraceptive Agents Phase 3
36 Contraceptives, Oral Phase 3
37 Contraceptives, Oral, Combined Phase 3
38 Cortisol succinate Phase 3
39 Norgestimate, ethinyl estradiol drug combination Phase 3
40 Nucleic Acid Synthesis Inhibitors Phase 3
41 Hydrocortisone 17-butyrate 21-propionate Phase 3
42 Hydrocortisone acetate Phase 3
43 Hydrocortisone-17-butyrate Phase 3
44 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
45 Estradiol 17 beta-cypionate Phase 3
46 Estradiol 3-benzoate Phase 3
47 Plasma Substitutes Phase 3
48 Polyestradiol phosphate Phase 3
49 Povidone Phase 3
50 Fluoroquinolones Phase 3

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Comparative Efficacy and Safety of Two Ciprofloxacin 0.3% and Dexamethasone 0.1% Formulations in Subjects With Acute Otitis Externa Unknown status NCT02216071 Phase 3
2 Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. Unknown status NCT00967317 Phase 3
3 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535560 Phase 3
4 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535599 Phase 3
5 FST-201 in the Treatment of Acute Otitis Externa Completed NCT00961675 Phase 3
6 Phase 3 Study of OTO-201 in Acute Otitis Externa Completed NCT02801370 Phase 3
7 A Phase III Study of an Otic Formulation in Acute Otitis Externa Completed NCT00750633 Phase 3
8 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3
9 FST-201 In The Treatment of Acute Otitis Externa Terminated NCT00945802 Phase 3
10 A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa Terminated NCT01910155 Phase 3
11 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3
12 Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R) Unknown status NCT01584271 Phase 2
13 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2
14 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2
15 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis Completed NCT01447017 Phase 2
16 Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa Completed NCT00872209 Phase 1, Phase 2
17 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis Completed NCT01157819 Phase 2
18 Topical Voltaren in Otitis Externa Terminated NCT00523120 Phase 2
19 Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations Completed NCT02558738
20 Evaluation of Middle Ear Implantation Completed NCT00451503
21 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Recruiting NCT02918773

Search NIH Clinical Center for Otitis Externa

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: otitis externa

Genetic Tests for Otitis Externa

Anatomical Context for Otitis Externa

MalaCards organs/tissues related to Otitis Externa:

39
Bone, Brain, Testes, Skin, Tonsil

Publications for Otitis Externa

Articles related to Otitis Externa:

(show top 50) (show all 559)
id Title Authors Year
1
Langerhans Cell Histiocytosis Presenting as Chronic Otitis Externa. ( 28045847 )
2017
2
Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. ( 27806892 )
2017
3
Kit to help owners administer treatment for otitis externa. ( 27450853 )
2016
4
Determination of N-acylhomoserine lactones of Pseudomonas aeruginosa in clinical samples from dogs with otitis externa. ( 27756390 )
2016
5
Malignant otitis externa hospitalizations: Analysis of patient characteristics. ( 27882553 )
2016
6
Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy. ( 27570137 )
2016
7
Serum Malassezia-specific IgE in dogs with recurrent Malassezia otitis externa without concurrent skin disease. ( 27288851 )
2016
8
Scedosporium apiospermum: a rare cause of malignant otitis externa. ( 27613266 )
2016
9
Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results. ( 26743397 )
2016
10
Antimicrobial resistance, integron carriage, and gyrA and gyrB mutations in Pseudomonas aeruginosa isolated from dogs with otitis externa and pyoderma in Brazil. ( 26833540 )
2016
11
Scedosporium prolificans Otitis Externa. ( 27753775 )
2016
12
Chorda tympani schwannoma: one new case revealed during malignant otitis externa and review of the literature. ( 26952150 )
2016
13
Diffusion-weighted Magnetic Resonance Imaging as a Novel Imaging Modality in Assessing Treatment Response in Necrotizing Otitis Externa. ( 27050654 )
2016
14
First report of otitis externa caused by Schizophyllum commune and review of the literature. ( 26802032 )
2016
15
Bacterial Otitis Externa in Patients Attending an ENT Clinic in Babol, North of Iran. ( 27127584 )
2016
16
A rare case of extensive cranial Langerhans cell histiocytosis, synchronously presenting as otitis externa and giant cell arteritis. ( 27908938 )
2016
17
Antibacterial effect of N-acetylcysteine on common canine otitis externa isolates. ( 27122224 )
2016
18
Otitis externa lecture online. ( 27770104 )
2016
19
Comparison of Boric Acid and Combination Drug of Polymyxin, Neomycin and Hydrocortisone (polymyxin NH) in the Treatment of Acute Otitis Externa. ( 27630871 )
2016
20
Traditional Mediterranean plants: characterization and use of an essential oils mixture to treat Malassezia otitis externa in atopic dogs. ( 27917678 )
2016
21
Treatment for otitis externa in dogs. ( 26966310 )
2016
22
Efficacy of medical grade honey in the management of canine otitis externa - a pilot study. ( 26929137 )
2016
23
Heterotopic ossification in chronic fibrosing otitis externa. ( 26429555 )
2015
24
Experimental treatment of recurrent otitis externa. ( 26623362 )
2015
25
Malignant otitis externa in a healthy non-diabetic patient. ( 26233245 )
2015
26
Necrotising (malignant) otitis externa in the UK: a growing problem. Review of five cases and analysis of national Hospital Episode Statistics trends. ( 25990028 )
2015
27
Malignant Otitis Externa: A Novel Stratification Protocol for Predicting Treatment Outcomes. ( 26375971 )
2015
28
Malignant Otitis Externa - A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. ( 26223723 )
2015
29
First identification of methicillin-resistant Staphylococcus pseudintermedius strains among coagulase-positive staphylococci isolated from dogs with otitis externa in Trinidad, West Indies. ( 26715379 )
2015
30
Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa. ( 25823453 )
2015
31
Septic arthritis of the temporomandibular joint caused by Aspergillus flavus infection as a complication of otitis externa. ( 25738723 )
2015
32
Relapsing polychondritis presenting as recurrent otitis externa. ( 26551502 )
2015
33
Pattern of otitis externa in Kaduna Nigeria. ( 26328002 )
2015
34
A Novel Mycobacterium cosmeticum-Like Bacterium Isolated from the Ear Swab of a Patient with Otitis Externa. ( 25866687 )
2015
35
Case report: facial nerve palsy, necrotising otitis externa and leishmaniasis. ( 26494710 )
2015
36
Comparison of lipid profiles of Malassezia pachydermatis strains isolated from dogs with otitis externa and without clinical symptoms of disease. ( 26559663 )
2015
37
Antibiotic Prescribing Trends in Necrotising Otitis Externa: A Survey of 85 Trusts in the United Kingdom. ( 26352779 )
2015
38
Malignant otitis externa. ( 25923266 )
2015
39
Hypoglossal paresis as the only complication of malignant otitis externa. ( 26601558 )
2015
40
Ear gel to treat otitis externa in dogs. ( 26475907 )
2015
41
American Academy of Otolaryngology: head and neck surgery foundation clinical practice guideline on acute otitis externa 2014. ( 26187983 )
2015
42
Otitis externa. ( 26074134 )
2015
43
RESPONSE TO LETTER TO THE EDITOR RE: CLINICAL OUTCOME PARAMETERS FOR NECROTIZING OTITIS EXTERNA. ( 25839975 )
2015
44
Fungal otitis externa as a cause of tympanic membrane perforation: a case series. ( 25181663 )
2014
45
Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. ( 24963511 )
2014
46
Management and outcomes in patients affected by malignant otitis externa. ( 25344095 )
2014
47
Cervical internal carotid Artery pseudoaneurysm complicating malignant otitis externa: First case report. ( 25124769 )
2014
48
Ciprofloxacin plus fluocinolone acetonide versus ciprofloxacin alone in the treatment of diffuse otitis externa. ( 25000552 )
2014
49
Cholesteatoma and meningoencephalitis in a dog with chronic otitis externa. ( 25385218 )
2014
50
In vitro antifungal susceptibility of Malassezia pachydermatis strains isolated from dogs with chronic and acute otitis externa. ( 25031085 )
2014

Variations for Otitis Externa

Expression for Otitis Externa

Search GEO for disease gene expression data for Otitis Externa.

Pathways for Otitis Externa

Pathways related to Otitis Externa according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CALM1 CALM2 CALM3 POLB
2
Show member pathways
12.55 CALM1 CALM2 CALM3
3
Show member pathways
12.52 CALM1 CALM2 CALM3
4
Show member pathways
12.51 CALM1 CALM2 CALM3
5
Show member pathways
12.49 CALM1 CALM2 CALM3
6
Show member pathways
12.49 CALM1 CALM2 CALM3
7
Show member pathways
12.46 CALM1 CALM2 CALM3
8
Show member pathways
12.45 CALM1 CALM2 CALM3
9
Show member pathways
12.43 CALM1 CALM2 CALM3
10
Show member pathways
12.42 CALM1 CALM2 CALM3
11
Show member pathways
12.41 CALM1 CALM2 CALM3
12
Show member pathways
12.4 CALM1 CALM2 CALM3
13
Show member pathways
12.38 CALM1 CALM2 CALM3
14
Show member pathways
12.33 CALM1 CALM2 CALM3
15
Show member pathways
12.33 CALM1 CALM2 CALM3
16
Show member pathways
12.31 CALM1 CALM2 CALM3
17
Show member pathways
12.31 CALM1 CALM2 CALM3
18
Show member pathways
12.3 CALM1 CALM2 CALM3
19
Show member pathways
12.29 CALM1 CALM2 CALM3
20
Show member pathways
12.29 CALM1 CALM2 CALM3
21
Show member pathways
12.27 CALM1 CALM2 CALM3
22 12.26 CALM1 CALM2 CALM3
23
Show member pathways
12.25 CALM1 CALM2 CALM3
24
Show member pathways
12.24 CALM1 CALM2 CALM3
25
Show member pathways
12.24 CALM1 CALM2 CALM3
26
Show member pathways
12.22 CALM1 CALM2 CALM3
27
Show member pathways
12.22 CALM1 CALM2 CALM3
28
Show member pathways
12.21 CALM1 CALM2 CALM3
29
Show member pathways
12.19 CALM1 CALM2 CALM3
30
Show member pathways
12.16 CALM1 CALM2 CALM3
31
Show member pathways
12.16 CALM1 CALM2 CALM3
32
Show member pathways
12.15 CALM1 CALM2 CALM3
33
Show member pathways
12.13 CALM1 CALM2 CALM3
34 12.12 CALM1 CALM2 CALM3
35
Show member pathways
12.1 CALM1 CALM2 CALM3
36
Show member pathways
12.09 CALM1 CALM2 CALM3
37
Show member pathways
12.08 CALM1 CALM2 CALM3
38
Show member pathways
12.06 CALM1 CALM2 CALM3
39
Show member pathways
12.04 CALM1 CALM2 CALM3
40
Show member pathways
12.02 CALM1 CALM2 CALM3
41 11.99 CALM1 CALM2 CALM3
42 11.99 CALM1 CALM2 CALM3
43
Show member pathways
11.92 CALM1 CALM2 CALM3
44
Show member pathways
11.9 CALM1 CALM2 CALM3
45
Show member pathways
11.88 CALM1 CALM2 CALM3
46
Show member pathways
11.85 CALM1 CALM2 CALM3
47 11.83 CALM1 CALM2 CALM3
48 11.82 CALM1 CALM2 CALM3
49
Show member pathways
11.8 CALM1 CALM2 CALM3
50
Show member pathways
11.77 CALM1 CALM2 CALM3

GO Terms for Otitis Externa

Cellular components related to Otitis Externa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.54 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.5 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.43 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.33 CALM1 CALM2 CALM3
5 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
6 spindle microtubule GO:0005876 8.92 CALM1 CALM2 CALM3 POLB

Biological processes related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.94 CALM1 CALM2 CALM3 DOCK8
2 ion transmembrane transport GO:0034220 9.82 CALM1 CALM2 CALM3
3 Fc-epsilon receptor signaling pathway GO:0038095 9.82 CALM1 CALM2 CALM3
4 platelet degranulation GO:0002576 9.81 CALM1 CALM2 CALM3
5 muscle contraction GO:0006936 9.8 CALM1 CALM2 CALM3
6 response to calcium ion GO:0051592 9.8 CALM1 CALM2 CALM3
7 inositol phosphate metabolic process GO:0043647 9.79 CALM1 CALM2 CALM3
8 substantia nigra development GO:0021762 9.79 CALM1 CALM2 CALM3
9 protein methylation GO:0006479 9.78 CALM1 CALM2 CALM3
10 positive regulation of protein serine/threonine kinase activity GO:0071902 9.77 CALM1 CALM2 CALM3
11 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.77 CALM1 CALM2 CALM3
12 regulation of heart rate GO:0002027 9.76 CALM1 CALM2 CALM3
13 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.75 CALM1 CALM2 CALM3
14 regulation of rhodopsin mediated signaling pathway GO:0022400 9.74 CALM1 CALM2 CALM3
15 regulation of nitric-oxide synthase activity GO:0050999 9.73 CALM1 CALM2 CALM3
16 positive regulation of protein autophosphorylation GO:0031954 9.72 CALM1 CALM2 CALM3
17 regulation of cytokinesis GO:0032465 9.71 CALM1 CALM2 CALM3
18 regulation of cardiac muscle contraction GO:0055117 9.7 CALM1 CALM2 CALM3
19 positive regulation of protein dephosphorylation GO:0035307 9.69 CALM1 CALM2 CALM3
20 glycogen catabolic process GO:0005980 9.67 CALM1 CALM2 CALM3
21 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
22 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.63 CALM1 CALM2 CALM3
23 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
26 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
27 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
28 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
29 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
30 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.69 CALM1 CALM2 CALM3
2 protein domain specific binding GO:0019904 9.67 CALM1 CALM2 CALM3
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.65 CALM1 CALM2 CALM3
4 ion channel binding GO:0044325 9.63 CALM1 CALM2 CALM3
5 ligand-gated ion channel activity GO:0015276 9.61 CALM1 CALM2 CALM3
6 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
7 phospholipase binding GO:0043274 9.54 CALM1 CALM2 CALM3
8 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
9 thioesterase binding GO:0031996 9.43 CALM1 CALM2 CALM3
10 inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 9.33 CALM1 CALM2 CALM3
11 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
12 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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