Aliases & Classifications for Otitis Externa

MalaCards integrated aliases for Otitis Externa:

Name: Otitis Externa 12 42 14 69
Acute Infective Otitis Externa 69
Infective Otitis Externa 69
Swimmer's Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9463
ICD9CM 35 380.1 380.10
MeSH 42 D010032
NCIt 47 C3299
ICD10 33 H60 H62.4
UMLS 69 C0021355

Summaries for Otitis Externa

Disease Ontology : 12 An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections.

MalaCards based summary : Otitis Externa, also known as acute infective otitis externa, is related to malignant otitis externa and chronic fungal otitis externa. An important gene associated with Otitis Externa is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Endothelin-1/EDNRA signaling. The drugs Cipro and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain.

Wikipedia : 72 Otitis externa, also known as swimmer\'s ear, is an inflammation of the ear canal. It often presents... more...

Related Diseases for Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 malignant otitis externa 12.6
2 chronic fungal otitis externa 12.1
3 beach ear 11.6
4 otomycosis 11.3
5 acute infection of pinna 11.0
6 perichondritis of auricle 11.0
7 otitis media 10.4
8 osteomyelitis 10.3
9 cholesteatoma of external ear 10.3
10 mastoiditis 10.1
11 dermatitis 10.1
12 pyoderma 10.1
13 cervicitis 10.0
14 contact dermatitis 10.0
15 histiocytosis 10.0
16 encephalomalacia 10.0 CALM1 CALM3
17 arthritis 9.9
18 leukemia 9.9
19 suppurative otitis media 9.9
20 squamous cell carcinoma 9.9
21 allergic contact dermatitis 9.9
22 cranial nerve palsy 9.9
23 pneumonia 9.9
24 septic arthritis 9.9
25 leishmaniasis 9.9
26 subclavian steal syndrome 9.8 CALM1 CALM2 CALM3
27 long qt syndrome 15 9.8 CALM1 CALM2 CALM3
28 heterotaxy, visceral, 8, autosomal 9.8 CALM1 CALM2 CALM3
29 pseudohypoaldosteronism, type iic 9.8 CALM1 CALM2 CALM3
30 pontiac fever 9.8 CALM1 CALM2 CALM3
31 cutaneous leishmaniasis 9.8
32 skin disease 9.8
33 adenoiditis 9.8
34 sensorineural hearing loss 9.8
35 lymphoblastic leukemia 9.8
36 tonsillitis 9.8
37 nasopharyngitis 9.8
38 meningoencephalitis 9.8
39 lemierre's syndrome 9.8
40 ecthyma 9.8
41 optic neuritis 9.8
42 multiple cranial nerve palsy 9.8
43 facial paralysis 9.8
44 papilledema 9.8
45 cystitis 9.8
46 neuritis 9.8
47 relapsing polychondritis 9.8
48 adenocarcinoma 9.8
49 cerebritis 9.8
50 laryngitis 9.8

Comorbidity relations with Otitis Externa via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Hypertension, Essential Ischemic Heart Disease
Otitis Media

Graphical network of the top 20 diseases related to Otitis Externa:



Diseases related to Otitis Externa

Symptoms & Phenotypes for Otitis Externa

Drugs & Therapeutics for Otitis Externa

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cipro 17 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer June 1997

Drugs for Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 3,Phase 2,Phase 1 85721-33-1 2764
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
3
Dipivefrin Approved Phase 3,Phase 2,Phase 1 52365-63-6 3105
4
Povidone Approved Phase 3 9003-39-8
5 Povidone-iodine Approved Phase 3 25655-41-8
6
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
8
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
9
Norgestimate Approved Phase 3 35189-28-7 6540478
10
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
11
Iodine Investigational Phase 3 7553-56-2 807
12
Butyric Acid Experimental Phase 3 107-92-6 264
13 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
14 Antiemetics Phase 3,Phase 2
15 Anti-Infective Agents Phase 3,Phase 2,Phase 1
16 Anti-Inflammatory Agents Phase 3,Phase 2
17 Antineoplastic Agents, Hormonal Phase 3,Phase 2
18 Autonomic Agents Phase 3,Phase 2
19 BB 1101 Phase 3,Phase 2
20 Cytochrome P-450 CYP1A2 Inhibitors Phase 3,Phase 2,Phase 1
21 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
22 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
23 Gastrointestinal Agents Phase 3,Phase 2
24 glucocorticoids Phase 3,Phase 2
25 HIV Protease Inhibitors Phase 3,Phase 2
26 Hormone Antagonists Phase 3,Phase 2
27 Hormones Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
29 Peripheral Nervous System Agents Phase 3,Phase 2
30
protease inhibitors Phase 3,Phase 2
31 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
32 Dexamethasone 21-phosphate Phase 3,Phase 2
33 Antibiotics, Antitubercular Phase 3,Phase 2
34 Anti-Infective Agents, Local Phase 3
35 Blood Substitutes Phase 3
36 cadexomer iodine Phase 3
37 Plasma Substitutes Phase 3
38 Contraceptive Agents Phase 3
39 Contraceptives, Oral Phase 3
40 Contraceptives, Oral, Combined Phase 3
41 Estradiol 17 beta-cypionate Phase 3
42 Estradiol 3-benzoate Phase 3
43 Estradiol valerate Phase 3 979-32-8
44 Fluoroquinolones Phase 3
45 Norgestimate, ethinyl estradiol drug combination Phase 3
46 Nucleic Acid Synthesis Inhibitors Phase 3
47 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
48 Polyestradiol phosphate Phase 3
49 Ciprofloxacin, hydrocortisone drug combination Phase 3
50 Cortisol succinate Phase 3

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 Comparative Efficacy and Safety of Two Ciprofloxacin 0.3% and Dexamethasone 0.1% Formulations in Subjects With Acute Otitis Externa Unknown status NCT02216071 Phase 3 Ciprodex®;EXL CDOS (Ciprofloxacin 0.3% and Dexamethasone 0.1%) Sterile Otic Suspension
2 Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. Unknown status NCT00967317 Phase 3 Auris-Sedina;Otosynalar®
3 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535560 Phase 3 AL-60371, 0.3% otic suspension;AL-60371 Vehicle
4 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa Completed NCT01535599 Phase 3 AL-60371, 0.3% Otic Suspension
5 FST-201 in the Treatment of Acute Otitis Externa Completed NCT00961675 Phase 3 FST201 (dexamethasone 0.1% with povidone-iodine 1%);Ciprodex (Ciprofloxacin 0.3%; dexamethasone 0.1% )
6 Phase 3 Study of OTO-201 in Acute Otitis Externa Completed NCT02801370 Phase 3 12 mg ciprofloxacin;Sham Control
7 A Phase III Study of an Otic Formulation in Acute Otitis Externa Completed NCT00750633 Phase 3 Moxidex otic solution;Moxifloxacin otic solution;Dexamethasone phosphate otic solution
8 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
9 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa Recruiting NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
10 FST-201 In The Treatment of Acute Otitis Externa Terminated NCT00945802 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;ciprofloxacin 0.3%, dexamethasone 0.1%
11 A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa Terminated NCT01910155 Phase 3 Ciprofloxacin/Dexamethasone;Ciprodex (R);Placebo
12 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
13 Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R) Unknown status NCT01584271 Phase 2
14 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
15 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
16 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis Completed NCT01447017 Phase 2 DPK-060;Placebo for DPK-060 ear drops
17 Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa Completed NCT00872209 Phase 1, Phase 2 0.3% Ciprofloxacin Ear Drops;0.3% Ciprofloxacin Foam Otic Cipro
18 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis Completed NCT01157819 Phase 2 0.3% Ciprofloxacin Ear Drops;FoamOtic Cipro
19 Topical Voltaren in Otitis Externa Terminated NCT00523120 Phase 2 diclofenac sodium;dexotc
20 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Completed NCT02918773
21 Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations Completed NCT02558738
22 Evaluation of Middle Ear Implantation Completed NCT00451503

Search NIH Clinical Center for Otitis Externa

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: otitis externa

Genetic Tests for Otitis Externa

Anatomical Context for Otitis Externa

MalaCards organs/tissues related to Otitis Externa:

39
Bone, Skin, Brain, Tonsil, Testes

Publications for Otitis Externa

Articles related to Otitis Externa:

(show top 50) (show all 574)
id Title Authors Year
1
Survey of otitis externa in American Cocker Spaniels in Finland. ( 28241842 )
2017
2
Otitis externa in military divers: more frequent and less harmful than reported. ( 28357818 )
2017
3
Necrotising otitis externa due to Scopulariopsis brevicaulis in a patient without predisposing factors. ( 28473174 )
2017
4
The role of surgery in necrotizing otitis externa. ( 28122107 )
2017
5
A Case of Cutaneous Leishmaniasis guyanensis Mimicking Otitis Externa. ( 28811000 )
2017
6
Antibacterial and Antifungal Activity of Essential Oils against Pathogens Responsible for Otitis Externa in Dogs and Cats. ( 28930236 )
2017
7
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
8
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
9
Langerhans Cell Histiocytosis Presenting as Chronic Otitis Externa. ( 28045847 )
2017
10
Fungal malignant otitis externa. ( 28348261 )
2017
11
Optimising the use of otowicks in otitis externa. ( 28693628 )
2017
12
Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat. ( 28491450 )
2017
13
Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. ( 28301961 )
2017
14
Epidemiological study of dogs with otitis externa in Cape Breton, Nova Scotia. ( 28216686 )
2017
15
Is malignant otitis externa on the increase? A retrospective review of cases. ( 28231368 )
2017
16
Impact of a terbinafine-florfenicol-betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners. ( 28295766 )
2017
17
Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. ( 27806892 )
2017
18
A rare case of extensive cranial Langerhans cell histiocytosis, synchronously presenting as otitis externa and giant cell arteritis. ( 27908938 )
2016
19
First report of otitis externa caused by Schizophyllum commune and review of the literature. ( 26802032 )
2016
20
Efficacy of medical grade honey in the management of canine otitis externa - a pilot study. ( 26929137 )
2016
21
Determination of N-acylhomoserine lactones of Pseudomonas aeruginosa in clinical samples from dogs with otitis externa. ( 27756390 )
2016
22
Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy. ( 27570137 )
2016
23
Serum Malassezia-specific IgE in dogs with recurrent Malassezia otitis externa without concurrent skin disease. ( 27288851 )
2016
24
Diffusion-weighted Magnetic Resonance Imaging as a Novel Imaging Modality in Assessing Treatment Response in Necrotizing Otitis Externa. ( 27050654 )
2016
25
Treatment for otitis externa in dogs. ( 26966310 )
2016
26
Otitis externa lecture online. ( 27770104 )
2016
27
Antimicrobial resistance, integron carriage, and gyrA and gyrB mutations in Pseudomonas aeruginosa isolated from dogs with otitis externa and pyoderma in Brazil. ( 26833540 )
2016
28
Traditional Mediterranean plants: characterization and use of an essential oils mixture to treat Malassezia otitis externa in atopic dogs. ( 27917678 )
2016
29
Scedosporium prolificans Otitis Externa. ( 27753775 )
2016
30
Scedosporium apiospermum: a rare cause of malignant otitis externa. ( 27613266 )
2016
31
Bacterial Otitis Externa in Patients Attending an ENT Clinic in Babol, North of Iran. ( 27127584 )
2016
32
Antibacterial effect of N-acetylcysteine on common canine otitis externa isolates. ( 27122224 )
2016
33
Malignant otitis externa hospitalizations: Analysis of patient characteristics. ( 27882553 )
2016
34
Kit to help owners administer treatment for otitis externa. ( 27450853 )
2016
35
Chorda tympani schwannoma: one new case revealed during malignant otitis externa and review of the literature. ( 26952150 )
2016
36
Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results. ( 26743397 )
2016
37
Comparison of Boric Acid and Combination Drug of Polymyxin, Neomycin and Hydrocortisone (polymyxin NH) in the Treatment of Acute Otitis Externa. ( 27630871 )
2016
38
Otitis externa. ( 26074134 )
2015
39
Malignant otitis externa in a healthy non-diabetic patient. ( 26233245 )
2015
40
First identification of methicillin-resistant Staphylococcus pseudintermedius strains among coagulase-positive staphylococci isolated from dogs with otitis externa in Trinidad, West Indies. ( 26715379 )
2015
41
Hypoglossal paresis as the only complication of malignant otitis externa. ( 26601558 )
2015
42
Malignant Otitis Externa - A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. ( 26223723 )
2015
43
Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa. ( 25823453 )
2015
44
American Academy of Otolaryngology: head and neck surgery foundation clinical practice guideline on acute otitis externa 2014. ( 26187983 )
2015
45
Heterotopic ossification in chronic fibrosing otitis externa. ( 26429555 )
2015
46
RESPONSE TO LETTER TO THE EDITOR RE: CLINICAL OUTCOME PARAMETERS FOR NECROTIZING OTITIS EXTERNA. ( 25839975 )
2015
47
Septic arthritis of the temporomandibular joint caused by Aspergillus flavus infection as a complication of otitis externa. ( 25738723 )
2015
48
Antibiotic Prescribing Trends in Necrotising Otitis Externa: A Survey of 85 Trusts in the United Kingdom. ( 26352779 )
2015
49
Pattern of otitis externa in Kaduna Nigeria. ( 26328002 )
2015
50
A Novel Mycobacterium cosmeticum-Like Bacterium Isolated from the Ear Swab of a Patient with Otitis Externa. ( 25866687 )
2015

Variations for Otitis Externa

Expression for Otitis Externa

Search GEO for disease gene expression data for Otitis Externa.

Pathways for Otitis Externa

Pathways related to Otitis Externa according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CALM1 CALM2 CALM3 DOCK8
2
Show member pathways
12.62 CALM1 CALM2 CALM3
3
Show member pathways
12.58 CALM1 CALM2 CALM3
4
Show member pathways
12.58 CALM1 CALM2 CALM3
5
Show member pathways
12.55 CALM1 CALM2 CALM3
6
Show member pathways
12.52 CALM1 CALM2 CALM3
7
Show member pathways
12.51 CALM1 CALM2 CALM3
8
Show member pathways
12.49 CALM1 CALM2 CALM3
9
Show member pathways
12.49 CALM1 CALM2 CALM3
10
Show member pathways
12.46 CALM1 CALM2 CALM3
11
Show member pathways
12.44 CALM1 CALM2 CALM3
12
Show member pathways
12.42 CALM1 CALM2 CALM3
13
Show member pathways
12.42 CALM1 CALM2 CALM3
14
Show member pathways
12.41 CALM1 CALM2 CALM3
15
Show member pathways
12.4 CALM1 CALM2 CALM3
16
Show member pathways
12.33 CALM1 CALM2 CALM3
17
Show member pathways
12.32 CALM1 CALM2 CALM3
18
Show member pathways
12.31 CALM1 CALM2 CALM3
19
Show member pathways
12.3 CALM1 CALM2 CALM3
20
Show member pathways
12.3 CALM1 CALM2 CALM3
21
Show member pathways
12.29 CALM1 CALM2 CALM3
22
Show member pathways
12.28 CALM1 CALM2 CALM3
23
Show member pathways
12.27 CALM1 CALM2 CALM3
24
Show member pathways
12.25 CALM1 CALM2 CALM3
25 12.25 CALM1 CALM2 CALM3
26
Show member pathways
12.24 CALM1 CALM2 CALM3
27
Show member pathways
12.23 CALM1 CALM2 CALM3
28
Show member pathways
12.22 CALM1 CALM2 CALM3
29
Show member pathways
12.22 CALM1 CALM2 CALM3
30
Show member pathways
12.21 CALM1 CALM2 CALM3
31
Show member pathways
12.18 CALM1 CALM2 CALM3
32
Show member pathways
12.16 CALM1 CALM2 CALM3
33
Show member pathways
12.16 CALM1 CALM2 CALM3
34
Show member pathways
12.15 CALM1 CALM2 CALM3
35
Show member pathways
12.13 CALM1 CALM2 CALM3
36 12.12 CALM1 CALM2 CALM3
37
Show member pathways
12.1 CALM1 CALM2 CALM3
38
Show member pathways
12.09 CALM1 CALM2 CALM3
39
Show member pathways
12.08 CALM1 CALM2 CALM3
40
Show member pathways
12.06 CALM1 CALM2 CALM3
41
Show member pathways
12.04 CALM1 CALM2 CALM3
42
Show member pathways
12.02 CALM1 CALM2 CALM3
43 11.99 CALM1 CALM2 CALM3
44 11.99 CALM1 CALM2 CALM3
45
Show member pathways
11.92 CALM1 CALM2 CALM3
46
Show member pathways
11.9 CALM1 CALM2 CALM3
47
Show member pathways
11.88 CALM1 CALM2 CALM3
48
Show member pathways
11.85 CALM1 CALM2 CALM3
49 11.83 CALM1 CALM2 CALM3
50 11.82 CALM1 CALM2 CALM3

GO Terms for Otitis Externa

Cellular components related to Otitis Externa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.43 CALM1 CALM2 CALM3
2 spindle pole GO:0000922 9.33 CALM1 CALM2 CALM3
3 sarcomere GO:0030017 9.13 CALM1 CALM2 CALM3
4 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Otitis Externa according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.74 CALM1 CALM2 CALM3
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.73 CALM1 CALM2 CALM3
3 regulation of heart rate GO:0002027 9.72 CALM1 CALM2 CALM3
4 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
5 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
6 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.69 CALM1 CALM2 CALM3
7 positive regulation of protein autophosphorylation GO:0031954 9.67 CALM1 CALM2 CALM3
8 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
10 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
11 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
12 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
13 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
14 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
15 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
16 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
17 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otitis Externa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.5 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.43 CALM1 CALM2 CALM3
3 protein serine/threonine kinase activator activity GO:0043539 9.33 CALM1 CALM2 CALM3
4 titin binding GO:0031432 9.13 CALM1 CALM2 CALM3
5 protein phosphatase activator activity GO:0072542 8.8 CALM1 CALM2 CALM3

Sources for Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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