Search MalaCards:
MCID: OTT002

Otitis Media malady
25 drugs, 127 genes, 6 tissues, 1029 related diseases, 28 phenotypes, 156 articles, clinical trials.

Summaries for Otitis Media

about this section
Sources:
6Disease Ontology, 2CDC, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Wikipedia: Otitis media (Latin) is inflammation of the middle ear, or middle ear infection.44 more...

MalaCards: Otitis Media, also known as ear infection &/or otitis media nos, is related to suppurative otitis media and chronic purulent otitis media. An important gene associated with Otitis Media is FBXO11 (F-box protein 11), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Bacterial infections in CF airways. The drugs cefaclor and sulfamethoxazole and the compounds cyclophosphamide and salmeterol have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and myeloid, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Disease Ontology: A otitis which involves inflammation of the middle ear.6

CDC: Español: Infecciones del oído2

Aliases & Descriptions for Otitis Media

about this section
Sources:
6Disease Ontology, 8DISEASES, 33OMIM, 32Novoseek , 2CDC, 43UMLS, 24MeSH, 40SNOMED-CT, 19ICD9CM, 27NCIt
See all sources

Aliases & Descriptions:

otitis media 6 8 33 32 43
ear infection &/or otitis media nos 6
otitis media nos (disorder) 6
unspecified otitis media 6
otitis media (disorder) 6
infectious otitis media 43
otitis media nos 6

External Ids:

ICD9CM19 382.9
SNOMED-CT40 267669008, 155222006, 194291009 65363002, more

Related Diseases for Otitis Media

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to otitis media by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1026)
idRelated DiseaseScoreTop Affiliating Genes
1suppurative otitis media36.7SERPINC1, CA13, CRP
2chronic purulent otitis media35.6COCH, HSF4, NR2F6
3adenoiditis32.3VCAM1, BMP6, BCL6, MUC1, MUC5AC, LACTB
4serous glue ear32.1SELL, VCAM1, BMP6, BCL6, MUC1, MUC12
5asthma32.1IL13, IL4, IL5, IGES, IGHE, RNASE3
6allergic rhinitis31.5MPO, IL13, IL4, IL5, IL8, CCL11
7haemophilus influenzae31.1MUC2, MUC5AC, LACTB, MPO, MED1, IL10
8cholesteatoma29.7MUC5AC, LACTB, CEACAM5, ITGAL, MMP2, MMP9
9infectious mononucleosis29.4CD79A, CD40LG, IL10, IL1A, IL2, IL6
10nasopharyngitis28.6VCAM1, BMP6, PARP1, LGALS9, MUC5AC, MUC5B
11sensorineural hearing loss28.4COCH, SERPINC1, SERPINE1, IL1A, F5, EYA4
12hearing loss28.3COCH, SERPINC1, SERPINE1, IL1A, IFNA1, F5
13cytomegalovirus infection27.6SELL, VCAM1, BMP6, MPO, CD40LG, ITGAL
14atopy27.2BCL6, MPO, CD79A, CD14, MIF, FGFR1
15turner syndrome27.1SERPINE1, CD79A, CD40LG, IL6, MBL2, GPT
16bronchial asthma26.6SELL, VCAM1, PARP1, MUC5AC, MPO, CD79A
17influenza26.5SFTPA1, SELL, SERPINE1, MYD88, MUC2, MUC5AC
18rhinitis26.5SFTPA1, SFTPA2, SELL, SERPINE1, VCAM1, MUC1
19pneumonia25.9SFTPA1, SELL, SERPINC1, SERPINE1, VCAM1, MYD88
20thrombosis24.8SELL, SERPINC1, SERPINE1, VCAM1, MUC1, MPO
21sinusitis24.8SELL, SERPINC1, SERPINE1, VCAM1, BMP6, MUC1
22intrinsic asthma14.2IL4, IL5, CCL5, IGES, IGHE, RNASE3
23eosinophilic pneumonia14.2IL13, IL5, CCL11, CCL17, CCL5, IGHE
24bullous pemphigoid14.2CD79A, ITGAL, IL13, IL5, CCL11, CCL17
25corneal ulcer14.1MUC5AC, MMP2, MMP9, IL1B, CCL11
26food allergy14.1IL13, IL4, IL5, CCL11, IGES, IGHE
27eosinophilic gastroenteritis14.1IL5, CCL11, IGES, IGHE, ALB, RNASE3
28allergic bronchopulmonary aspergillosis14.1IL4, IL5, MBL2, IGES, IGHE
29kimura disease14.1IL13, IL4, IL5, CCL11, IGES, IGHE
30vernal keratoconjunctivitis14.1VCAM1, MMP9, IL13, IL4, IL5, IL8
31parotitis14.1CD79A, MMP2, MMP9, HSF4, CRP, LTF
32cough variant asthma14.1IL10, IL4, IL5, IGHE, RNASE3
33eosinophilic esophagitis14.1VCAM1, MUC5AC, IL10, IL13, IL5, CCL11
34helminthiasis14.1IL13, IL5, IGHE, RNASE3
35giant papillary conjunctivitis14.1IL5, CCL11, RNASE3, LTF
36pulmonary eosinophilia14.1IL13, IL4, IL5, IL8, CCL11, CCL17
37vulvovaginitis14.1CD79A, IL10, IL13, IL4, IL5, MBL2
38eosinophilic meningitis14.1MMP9, IL10, IL2, IL4, IL5
39pthirus pubis infestation14.1MIF, IL5, CCL11, IGHE
40common cold14.1MUC5B, IL5, IL8, CCL11, ICAM1, ALB
41angiostrongyliasis14.1MMP9, IL13, IL2, IL4, IL5
42hypersensitivity reaction type iv disease14.1MIF, IL2, IL4, IGHE, IFNG, ICAM1
43b cell deficiency14.1CD79A, IL4, IL5, IGHE
44vulvovaginal candidiasis14.1CD79A, IL4, MBL2, DEFB1
45chronic eosinophilic pneumonia14.1IL5, CCL11, RNASE3
46infective endocarditis14.1SERPINC1, LACTB, FCGR2A, MBL2, CRP
47urinary schistosomiasis14.1IL10, IL13, IL4, IL5, IGHE, IFNG
48pulmonary tuberculosis14.1CD14, IL10, IL2, IL4, MBL2, IGES
49ocular cicatricial pemphigoid14.1CD79A, MIF, IL4, IL5, TNF, RNASE3
50stevens-johnson syndrome14.1CD79A, MMP2, MMP9, IL13, IL4, CCL17

Graphical network of the top 20 diseases related to otitis media:



Graphical network of diseases related to otitis media

Clinical Features for Otitis Media

about this section

Drugs & Therapeutics for Otitis Media

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for otitis media

Drug clinical trials:

Search ClinicalTrials for otitis media

Search NIH Clinical Center for otitis media

Search CenterWatch for otitis media

Inferred drug relations via UMLS/NDF-RT:

43 28 amoxicillin, amoxicillin trihydrate, antipyrine, azithromycin, azithromycin dihydrate, benzocaine, benzocaine pwdr [va product], cefaclor, cefaclor monohydrate, cefdinir, cefixime, cefpodoxime proxetil, cefprozil, ceftibuten, ceftibuten dihydrate, ceftibutin, ceftriaxone, ceftriaxone sodium, clarithromycin, loracarbef, penicillin v potassium, sulfamethoxazole, sulfisoxazole, sulfisoxazole acetyl, sulfisoxazole diolamine

Genetic Tests for Otitis Media

about this section

Anatomical Context for Otitis Media

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to otitis media:

22
Colon, Skin, Myeloid, T cells, B cells, Bronchial epithelium

Phenotypes for genes affiliated with Otitis Media

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to otitis media:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1craniofacial phenotypeMP:000538210.4CSF2, PRDM1, PKD1, RPL38, TRIM71, EYA4
2endocrine/exocrine gland phenotypeMP:000537910.1PRDM1, TLR2, LTA, IFNG, IL2, MED1
3renal/urinary system phenotypeMP:00053679.9C3, PREP, TGFB2, TLR7, PKD1, CTSL1
4respiratory system phenotypeMP:00053889.9PKD1, RPL38, NOS1, TBXA2R, TRIM71, CALCA
5hematopoietic system phenotypeMP:00053979.8CSF2, PRDM1, PREP, TLR7, KSR1, RPL38
6other phenotypeMP:00053959.7C3, CSF2, TLR2, PKD1, NOS2, NOS1
7limbs/digits/tail phenotypeMP:00053719.1RPL38, PKD1, LTA, TLR4, TGFB2, PRDM1
8hearing/vestibular/ear phenotypeMP:00053778.9TNFRSF11B, CTSL1, RPL38, TLR4, TGFB2, SOD1
9muscle phenotypeMP:00053698.3NOS1, NOS2, PKD1, TLR2, TGFB1, TGFB2
10liver/biliary system phenotypeMP:00053708.2IL2, MED1, XBP1, BCL6, SERPINC1, IL6
11digestive/alimentary phenotypeMP:00053818.2MUC1, MUC2, MUC5AC, MMP9, FGFR1, FBXO11
12reproductive system phenotypeMP:00053898.2BCL6, TBXA2R, TNFSF11, TNFRSF11A, TNF, IFNG
13normal phenotypeMP:00028738.1IFNG, ALB, SMAD2, NOS1, PKD1, ELANE
14no phenotypic analysisMP:00030127.8IL13, ID1, TP53, SMAD2, PRDM1, NEU1
15adipose tissue phenotypeMP:00053757.7KSR1, TLR2, TLR4, TGFB1, PREP, CSF2
16tumorigenesisMP:00020067.1CSF2, IL1A, IL10, MIF, MMP9, MMP2
17immune system phenotypeMP:00053876.9MBL2, FBXO11, IL6R, IL6, IL2, FGFR1
18skeleton phenotypeMP:00053906.8CSF2, TGFB2, PKD1, RPL38, NOS1, SMAD2
19vision/eye phenotypeMP:00053916.3TP53, HSF4, HTRA1, ICAM1, ID1, IFNG
20integument phenotypeMP:00107716.2CTSL1, PARP1, TNFSF11, TNFRSF11A, TP53, TRIM71
21behavior/neurological phenotypeMP:00053866.0LTA, KSR1, NOS2, NOS1, SMAD2, NR2F6
22growth/size phenotypeMP:00053785.6RPL38, SMAD2, TNFSF11, TNFRSF11B, TNFRSF11A, TP53
23cellular phenotypeMP:00053845.1NOS2, NOS1, SMAD2, CTSL1, TNFSF11, TNFRSF11B
24mortality/agingMP:00107684.9NEU1, C3, CSF2, PRDM1, DEFB1, TGFB2
25cardiovascular system phenotypeMP:00053854.3PKD1, RPL38, NOS2, NOS1, CRP, SMAD2
26homeostasis/metabolism phenotypeMP:00053763.4TNFRSF11A, ITGB2, ITGAL, CD40LG, CD14, CD79A
27embryogenesis phenotypeMP:0005380INFTRIM71, DYNC2LI1, RPL38, TGFB2, PRDM1, CSF2
28nervous system phenotypeMP:0003631INFTLR2, LTA, KSR1, PKD1, RPL38, TLR4

Publications for genes affiliated with Otitis Media

about this section
Sources:
35PubMed
See all sources

Articles related to otitis media:

(show top 50)    (show all 156)
idTitleAuthorsYearAffiliating Genes
1Evaluation of 15 functional candidate genes for assoc iation with chronic otitis media with effusion and/or recurrent otitis media (C OME/ROM). (21857919)Sale M.M.... Daly K.A.2011MUC5AC
2IgA and Differentiation-associated Transcription Fact ors in Chronic Otitis Media with Effusion. (19784405)Shin I.H.... Yeo S.G.2009XBP1, PRDM1
3Poly(I:C) synergizes with Th2 cytokines to induce TAR C/CCL17 in middle ear fibroblasts established from mucosa of otitis media with effusion. (19848242)Nonaka M.... Yagi T.2009IL4, IL13, CCL17
4Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. (18560870)Alper C.M.... Doyle W.J.2008TNF, IL6, IFNG
5Eya4-deficient mice are a model for heritable otitis media. (18219393)Depreux F.F.... Seidman J.G.2008EYA4
6Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. (18986247)Hernandez M.... Wasserman S.I.2008IRAK4, MYD88
7MUC2 expression in human middle ear epithelium of patients with otitis media. (18209134)Ubell M.L.... Burrows A.2008MUC2
8The 4G/4G plasminogen activator inhibitor-1 genotype is associated with frequent recurrence of acute otitis media. (17671042)Emonts M.... Sanders E.A.2007SERPINE1
9Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media. (17908769)Emonts M.... Sanders E.A.2007TNF, PARP1, IL6
10Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM). (16893079)Nuytinck L.... Govaerts P.2006MBL2
11Serum antibodies to pneumococcal neuraminidase NanA i n relation to pneumococcal carriage and acute otitis media. (16928889)Simell B.... KAoyhty H.2006NEU1
12The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion (16883790)Tian J.... Liu H.2006RNASE3, IGHE
13Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media. (16750996)Wiertsema S.P.... Rijkers G.T.2006MBL2
14Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. (16847180)Segade F.... Bowden D.W.2006FBXO11
15Expression of matrix metalloproteinase-9 and -2 in pediatric chronic otitis media with effusion. (16413616)Jang C.H.... Cho Y.B.2006MMP2, MMP9
16Total serum IgE and IgE antibodies specific to house dust mite found in two aged-matched cohorts of children with and without otitis media with effusion. (16620332)Coulson C.J.... Drayson M.T.2006IGHE, IGES
17The cytofluorometric opinion of expression of adhesion molecules CD11a and CD54 on lymphocytes T and B in children's hypertrophied adenoids, which are sick on the otitis media with effusion (17152810)Ratomski K.... Hassmann-Poznanska E.2006ITGAL
18Successful treatment of eosinophilic otitis media usi ng ramatroban: report of two cases. (16899348)Wada T.... Hara A.2006TBXA2R
19Impact of antibiotics on pathogens associated with otitis media with effusion. (16354337)Hamamoto Y.... Nibu K.2005MED1
20Immunological status in the aetiology of recurrent otitis media with effusion: serum immunoglobulin levels, functional mannose-binding lectin and Fc receptor polymorphisms for IgG. (15742161)Straetemans M.... Zielhuis G.A.2005MBL2, FCGR2A
21IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion. (12737295)Nonaka M.... Yagi T.2003CCL11, IL5
22Hyper immunoglobulin-E syndrome: a case with chronic ear draining mimicking polypoid otitis media. (12663115)GAPrA1r K.... VayisoA9lu Y.2003IGHE
23Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins. (11876602)Hotomi M.... Kuki K.2002MED1
24Effect of 23 valent pneumococcal polysaccharide and Haemophilus influenza conjugated vaccines on the clinical course of otitis media with effusion. (12439177)KiliAs R.... Samim E.2002LACTB
25How does endotoxin trigger inflammation in otitis media with effusion? (11210878)Schousboe L.P.... Pedersen C.B.2001ICAM1, IL1B, VCAM1
26Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma. (11468006)Iino Y.... Matsutani S.2001RNASE3, IGHE
27Properties of recombinant HtrA: an otitis media vaccine candidate antigen from non-typeable Haemophilus influenzae. (11214237)Cates G.A.... Loosmore S.M.2000HTRA1
28Viral RNA in middle ear mucosa and exudates in patients with chronic otitis media with effusion. (10979124)Moyse E.... Froehlich P.2000CCL5
29Increased expression of major basic protein (MBP) and interleukin-5(IL-5) in middle ear biopsy specimens from atopic patients with p ersistent otitis media with effusion. (11077335)Wright E.D.... Hamid Q.2000MBL2
30Carcinoembryonic antigen in chronic otitis media with cholesteatoma (10932614)Sankovic-Babic S.... Sofronic-Milosavljevic L.j.2000CEACAM5
31Eosinophils and neutrophils in biopsies from the middle ear of atopic children with otitis media with effusion. (10669113)Amin K.... Seveus L.1999RNASE3, CRISP3
32Serum interleukin-6 in bacterial and nonbacterial acute otitis media. (9685429)Heikkinen T.... Chonmaitree T.1998IL6
33Pattern of antimicrobial drug prescribing and prescriptive behaviour for acute otitis media among physicians in Sicily. (9642038)Mazzaglia G.... Caputi A.P.1998LACTB
34Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. (9041624)Gooch W.M.... Starobin S.1997LACTB
35Tumor necrosis factor during experimental lipopolysaccharide-induced otitis media. (9121315)DeMaria T.F.... Murwin D.M.1997TNF
36Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsies. (8822719)Hurst D.S.1996RNASE3, IGES
37Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. (8973284)Chonmaitree T.... Owen M.J.1996IL8
38Role of anaerobic bacteria in chronic otitis media an d cholesteatoma. (7782173)Brook I.1995LACTB
39Efficacy of 20- versus 10-day antimicrobial treatment for acute otitis media. (7596722)Mandel E.M.... Kurs-Lasky M.1995LACTB
40Bacteriology and beta-lactamase activity in ear aspir ates of acute otitis media that failed amoxicillin therapy. (8559633)Brook I.... Yocum P.1995LACTB
41Cerebellar venous infarction in chronic suppurative otitis media. A case report with review of four other cases. (8165678)Nayak A.K.... Meisheri Y.V.1994SERPINC1
42Cytokines in experimental otitis media with effusion. (8302123)Johnson M.D.... Kreutzer D.L.1994IL1B
43Interleukin-8 in otitis media with effusion. (7976312)Hotomi M.... Yamanaka N.1994IL8
44Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials. (8120703)Rosenfeld R.M.... Canafax D.M.1994LACTB
45Interleukin-8 expression in otitis media. (8052085)Maxwell K.S.... Kreutzer D.L.1994IL1B, IL8, LTA
46Antibiotic treatment of acute otitis media (1746853)Baron S.... BAcguAc P.1991LACTB
47The role of bacterial adherence in otitis media with effusion. (2206498)Shimamura K.... Mogi G.1990CD79A
48Activity of cefapirin against bacterial strains isol ated from acute otitis media in children (2114604)Simonet M.... Veron M.1990LACTB
49Correlation of immunoglobulins, the complement system and inflammatory mediators with reference to the pathogenesis of serous otitis media (2354013)Jeep S.1990CD40LG, KNG1, CD79A
50Prospective study about the incidence of B lactamase producing bacteriae in otitis media in the population of the emergency room of the University Pediatric Hospital. (2375816)ColA^n I.... GarcA-a H.1990LACTB

Expression for genes affiliated with Otitis Media

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Otitis Media

Pathways for genes affiliated with Otitis Media

about this section
Sources:
36QIAGEN, 41Thomson Reuters, 38Reactome, 10EMD Millipore, 37R&D Systems, 20KEGG
See all sources

Pathways related to otitis media according to GeneDecks:

(show top 50)    (show all 128)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3610.8CSF2, LTA, IL2, CCL11, CCL17, CCL5
2Bacterial infections in CF airways4110.5TLR2, CTSL1, IRAK4, MUC1, MYD88, SFTPA1
3PGC1Alpha Pathway3610.4CCL11, IL8, IL4, CCL17, CCL5, IL2
4IL-6 Pathway3610.3IL6R, IL8, CCL11, CCL5, TNFSF11, CSF2
5NFAT Signaling and Lymphocyte Interactions3610.3CCL17, IL5, IL4, IL2, IL13, IL1A
6Termination of O-glycan biosynthesis3810.3MUC2, MUC7, MUC6, MUC5B, MUC5AC, MUC4
7Immune response_Bacterial infections in normal airways4110.3MYD88, IL1B, NOS2, CD14, IFNG, IRAK4
8Immune response_MIF-mediated glucocorticoid regulation4110.1NOS2, TNF, IFNG, IL8, IL6, MIF
9Immune response MIF-mediated glucocorticoid regulation1010.1IL6, IL2, IFNG, MIF, VCAM1, ICAM1
10Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1010.0IRAK4, MYD88, CD14, IL6, CCL11, TLR7
11IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types379.9IL1B, IL13, IL4, IL5, IL6, TGFB2
12IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types379.8IL4, IL6, IL1B, IL6R, TLR2, TLR4
13Immune response_TLR signaling pathways419.8TLR7, TLR4, TLR2, CCL11, IL8, IL6
14Cytokine Network369.7IL1A, LTA, TNF, IFNG, IFNA1, IL8
15Amoebiasis209.7TGFB1, TGFB2, CSF2, TLR4, TLR2, MUC2
16Leishmaniasis209.6C3, TGFB2, TGFB1, TLR4, TLR2, NOS2
17PEDF Induced Signaling369.6CCL11, CCL17, CCL5, TNF, TNFSF11, LTA
18all-trans-Retinoic Acid Signaling in Brain369.5BMP6, IL10, LTA, CSF2, CCL11, TNFSF11
19Toll-like receptor signaling pathway209.5CCL5, IFNA1, TLR7, TLR4, TNF, TLR2
20Glucocorticoid Receptor Signaling369.5IL8, IL6R, IL6, IL5, IL4, IL2
21Rho Family GTPases369.4CSF2, ITGAL, CCL11, IL8, IL2, IL1B
22Endothelin-1 Signaling Pathway369.4BMP6, IL10, IL13, IL1A, IL1B, IL2
23Malaria209.4VCAM1, TNF, ICAM1, IFNG, IL8, IL6
24Immune response_MIF in innate immunity response419.4TLR4, NOS2, TNF, TP53, IFNG, IL8
25Immune response MIF in innate immunity response109.4IRAK4, CD14, MYD88, MIF, IL1B, TLR4
26STAT3 Pathway369.3IL2, IL4, IL5, IL6, IL6R, IL8
27MIF Mediated Glucocorticoid Regulation369.3IL2, IL4, IL5, IL6, IL8, CCL11
28PAK Pathway369.2CCL5, CCL17, CCL11, IL13, TNF, TNFSF11
29Akt Signaling369.2IL6R, CCL11, CCL17, CCL5, TNF, TNFRSF11A
30Pertussis209.2IL1B, IL1A, IL10, IRAK4, ITGB2, CD14
31SOCS Pathway369.2BMP6, CCL5, CCL17, IL8, IL6, IL2
32Regulation of eIF4 and p70S6K369.1EGF, CCL5, ITGAL, ITGB2, IL13, CCL11
33Tuberculosis209.0C3, IL10, FCGR2A, IRAK4, ITGB2, CD14
34Rheumatoid arthritis209.0TNFSF11, TNFRSF11A, TNF, ICAM1, IFNG, CCL5
35TGF-Beta Pathway368.9IL1B, EGF, FGFR1, IL10, IL13, IL6R
36Measles208.9IFNA1, IFNG, IL6, TP53, TLR2, TLR7
37TRAF Pathway368.9TLR7, IRAK4, IL1A, IL1B, MYD88, TLR4
38MIF Regulation of Innate Immune Cells368.8IL8, CCL17, CCL5, TP53, TNF, TNFSF11
39JAK-STAT Pathway368.8IL1B, IL2, IL4, BMP6, IL13, IL10
40ERK Signaling368.8ITGB2, BMP6, ITGAL, IL10, IL13, IL1A
41MAPK Family Pathway368.7CCL17, TNF, LTA, EGF, CCL11, IL13
42Tec Kinases Signaling368.6IL6, IL5, IL4, IL2, IL13, IL10
43NF-KappaB (p50-p65) Pathway368.5FGFR1, IL6, TLR7, TGFB1, TLR4, TLR2
44Chagas disease (American trypanosomiasis)208.4MYD88, IRAK4, IL10, IL1B, IL6, CCL5
45NF-KappaB Family Pathway368.4EGF, LTA, IL1B, TLR2, TLR4, TGFB1
46Colorectal Cancer Metastasis368.4TLR7, TLR4, TLR2, EGF, TNF, TP53
47Antioxidant Action of Vitamin-C368.3IL6, IL5, IL4, TNF, IL8, IL6R
48Cytokine-cytokine receptor interaction208.2IL5, IL4, IL2, IL1B, IL1A, IL13
49Molecular Mechanisms of Cancer368.0TGFB2, ITGAL, ITGB2, FGFR1, IL13, IL2
50p38 Signaling367.8BMP6, IRAK4, FGFR1, IL10, IL13, IL1A

Compounds for genes affiliated with Otitis Media

about this section
Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
See all sources

Compounds related to otitis media according to GeneDecks:

(show top 50)    (show all 447)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.6BCL6, ITGAL, ITGB2, MBL2, LTF
2salmeterol32 42 9 9 13.5ITGB2, IL13, IL2, IL4, IL5, IL8
3polyethylene glycol32 10.3SERPINC1, MUC1, MPO, NEU1
4sp 60012532 42 11.2VCAM1, IL13, TP53, TLR2
5sodium cromoglycate32 10.2VCAM1, CD79A, ITGAL, IL5, CCL11, IGHE
6isoproterenol32 9 9 12.0SELL, ITGAL, IL13, IL1A, IL5, IGHE
7ribavirin32 34 9 9 12.9CD40LG, MMP2, MMP9, IL10, IL2, IL4
8cetirizine32 9 18 9 12.9ITGAL, IL5, IL8, CCL11, IGHE, ICAM1
9aprotinin32 9 9 11.8SERPINC1, MMP2, MMP9, IL1A, IGHE, F5
10pmma32 9.7BMP6, CD40LG, CCL5, CALCA, TNFRSF11B, TNFSF11
11ns 39832 42 10.6PARP1, IL1A, IL1B, IL8, TNF, TNFRSF11B
12poly(i-c)32 9.6VCAM1, IL1B, IL4, IL5, IL6, IL8
13zymosan32 9.5MPO, CD14, ITGB2, IL1RN, MBL2, TNF
14gm-csf32 9.5BMP6, CD14, IL10, IL13, IL1A, IL1B
15aspartate32 9.5BMP6, CD14, CD40LG, ITGB2, MMP2, MMP9
16ascorbic acid32 18 10.4LEPREL1, CD40LG, MMP2, IL1A, IGHE, TNFRSF11B
17okt332 9.3VCAM1, BMP6, CD79A, CD40LG, ITGB2, IL10
18thalidomide32 42 9 9 12.3SELL, CD40LG, ITGB2, IL10, IL1B, IL2
19h2o232 9.1SELL, MPO, CD79A, ITGAL, ITGB2, MIF
20paraffin32 9.0SELL, VCAM1, BCL6, MUC1, MUC2, MUC5AC
21infliximab32 9 9 11.0IL10, IL1B, IL1RN, IL4, IL6, IGHE
22imiquimod32 42 9 9 12.0BMP6, IL10, IL1A, IL5, IL6, IL8
23il 1032 8.7BMP6, IL10, IL13, IL1A, IL1B, IL1RN
24superoxide32 18 9.6SELL, VCAM1, MPO, CD14, ITGAL, ITGB2
25prostacyclin32 8.6SERPINC1, SERPINE1, VCAM1, BMP6, FCGR2A, IL10
26tacrolimus32 34 9 9 11.5SERPINE1, BMP6, CD79A, ITGAL, IL10, IL13
27leukotriene b432 42 18 10.5SELL, MPO, ITGAL, ITGB2, MMP9, IL13
28neopterin32 8.4CD79A, CD14, CD40LG, IL10, IL1A, IL1B
29ly29400232 8.4MUC2, ITGB2, MMP2, MMP9, FCGR2A, IL10
30creatinine32 8.4SELL, SERPINC1, BMP6, MUC1, MPO, CD79A
31estrogen32 8.4SERPINC1, SERPINE1, MUC2, MUC4, MUC5AC, MUC6
32norepinephrine32 9 18 9 11.2SELL, VCAM1, BMP6, CD79A, CD14, CD40LG
33pge232 7.9VCAM1, MUC5AC, CD14, IL13, IL1A, IL1RN
34polymyxin b32 7.9SERPINE1, VCAM1, CD14, ITGB2, IL10, IL1A
35hydrocortisone32 9 9 9.8BMP6, MUC1, CD14, MMP2, MIF, IL10
36histamine32 18 8.8SELL, VCAM1, BMP6, MUC5AC, MPO, CD79A
37cyclosporin a32 42 8.6CD14, ITGAL, ITGB2, MMP9, IL10, IL13
38cholesterol32 9 18 9 10.6SERPINE1, VCAM1, MUC1, MUC2, MUC4, MUC5AC
39heparin32 9 18 9 10.5SERPINE1, MPO, CD79A, ITGAL, ITGB2, FGFR1
40pd 98,05932 7.4SERPINE1, VCAM1, BMP6, PARP1, MUC2, MUC5AC
41lactate32 7.4SELL, VCAM1, BMP6, BCL6, CEACAM5, MPO
42tgf beta132 7.3SERPINE1, VCAM1, BMP6, MMP2, IL10, IL13
43cysteine32 7.3COCH, PARP1, MUC1, MUC2, MUC5AC, MUC7
44testosterone32 9 18 9 10.3SERPINC1, VCAM1, MUC1, MUC5AC, CD79A, CD40LG
45sb 20358032 42 8.2VCAM1, BMP6, PARP1, ITGB2, MMP2, MMP9
46actinomycin d32 6.8SERPINE1, PARP1, MUC1, MUC2, CD40LG, ITGAL
47alanine32 6.7SELL, SERPINC1, SERPING1, VCAM1, BMP6, CD79A
48retinoic acid32 42 18 7.2SELL, SERPINE1, VCAM1, BMP6, PARP1, BCL6
49vegf32 4.8SERPINC1, SERPINE1, VCAM1, PARP1, MUC1, XBP1
50dexamethasone32 42 34 9 9 8.8SELL, SERPINC1, SERPINE1, VCAM1, BMP6, PARP1

GO Terms for genes affiliated with Otitis Media

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to otitis media according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.1DEFB1, TGFB1, MUC7, MUC6, MUC5B, MUC5AC
2external side of plasma membraneGO:0098979.7ICAM1, TNF, TNFRSF11A, TLR2, TLR4, IFNG
3platelet alpha granule lumenGO:0310938.4TGFB2, TGFB1, EGF, ALB, F5, SERPING1
4extracellular regionGO:0055765.6LYZ, KNG1, A1BG, C3, SFTPA1, MIF
5extracellular spaceGO:0056155.3MMP9, MIF, IL10, IL13, IL1A, IL1B

Biological processes related to otitis media according to GeneDecks:

(show top 50)    (show all 82)
idNameGO IDScoreTop Affiliating Genes
1O-glycan processingGO:01626610.8MUC7, MUC6, MUC5B, MUC5AC, MUC4, MUC2
2positive regulation of chemokine biosynthetic processGO:04508010.6TNF, MYD88, IL1B, IL4, IFNG
3positive regulation of NF-kappaB import into nucleusGO:04234610.5IL1B, TNF, TLR2, TLR7, TLR4
4lipopolysaccharide-mediated signaling pathwayGO:03166310.5MYD88, TGFB1, TLR4, TLR2, IL1B, CCL5
5B cell differentiationGO:03018310.5CD79A, IL4, IL10, CD40LG, VCAM1, BCL6
6positive regulation of B cell proliferationGO:03089010.5BCL6, MIF, TLR4, IL5, IL4, IL2
7defense response to bacteriumGO:04274210.4DEFB1, LYZ, DEFB123, TLR4, LTF, RNASE3
8positive regulation of cytokine secretionGO:05071510.4TNF, TLR2, IL1A, IL10, MIF, CD14
9positive regulation of MHC class II biosynthetic processGO:04534810.4IFNG, IL4, IL10, TLR4, CD40LG
10positive regulation of nitric oxide biosynthetic processGO:04542910.4TNF, ICAM1, HRH1, TLR4, IFNG, IL1B
11negative regulation of growth of symbiont in hostGO:04413010.4LTA, ELANE, TNF, IFNG, MBL2, TLR2
12positive regulation of interleukin-8 biosynthetic processGO:04541610.3TLR4, ELANE, TNF, TLR7
13positive regulation of T cell proliferationGO:04210210.3ITGAL, IL1B, IL4, IL6, CCL5, IFNG
14regulation of immune responseGO:05077610.3SELL, VCAM1, CD40LG, ITGAL, ITGB2, C3
15positive regulation of interferon-gamma productionGO:03272910.2CD40LG, IL1B, IL2, TNF, LTA, TLR4
16response to radiationGO:00931410.2TGFB2, TGFB1, TNFSF11, CCL11, MMP9
17chronic inflammatory response to antigenic stimulusGO:00243910.2IL1RN, IL1B
18leukocyte cell-cell adhesionGO:00715910.2VCAM1, CD40LG, ITGAL, ITGB2, CCL5, ICAM1
19innate immune responseGO:04508710.1C3, CD14, TLR7, TLR4, TLR2, CRISP3
20positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B, IFNG
21protein import into nucleus, translocationGO:00006010.0TNF, TGFB1, TP53, BCL6, IFNG
22response to heatGO:00940810.0CALCA, MMP9, SOD1, CD14, IL1B, NOS1
23positive regulation of chemokine productionGO:03272210.0TNF, IL6, TLR7, IL6R, TLR2, TLR4
24cellular response to lipopolysaccharideGO:07122210.0IL10, IL8, IFNG, ICAM1, NOS2, TLR4
25response to drugGO:04249310.0SOD1, TBXA2R, TNFRSF11B, LTA, TGFB1, TGFB2
26defense response to Gram-positive bacteriumGO:0508309.9LTA, MYD88, TLR2, IL6, IL6R, MBL2
27cell-cell signalingGO:0072679.9CALCA, TNFRSF11A, LTA, TGFB2, IL10, CCL5
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9IL4, IL10, TNFSF11, TNFRSF11A, IL1B, TNF
29positive regulation of interleukin-8 productionGO:0327579.9TLR7, TLR4, TLR2, CALCA, IL1B, SERPINE1
30positive regulation of angiogenesisGO:0457669.9MMP9, CCL11, TBXA2R, SERPINE1, C3, CCL5
31positive regulation of smooth muscle cell proliferationGO:0486619.8IRAK4, MYD88, IL13, IL6, IL6R, CCL5
32immune responseGO:0069559.8CSF2, C3, IL4, IL2, IL1RN, IL1A
33monocyte chemotaxisGO:0025489.7CCL5, IL6, IL6R, CALCA, TNFSF11, TNFRSF11A
34anti-apoptosisGO:0069169.7CD40LG, SOD1, TNF, IL2, MUC1, IL1A
35response to hypoxiaGO:0016669.6PDLIM1, TGFB2, LTA, TGFB1, TLR4, NOS2
36positive regulation of interleukin-6 productionGO:0327559.6IL1B, IL6, IL6R, TLR2, TLR4, TLR7
37response to lipopolysaccharideGO:0324969.5TLR4, LTA, TBXA2R, ELANE, TNFRSF11A, IL1A
38positive regulation of NF-kappaB transcription factor activityGO:0510929.5TGFB1, TLR4, TLR2, TNFRSF11A, TNFSF11, IL6
39positive regulation of MAP kinase activityGO:0434069.4TGFB1, ELANE, FGFR1, TNF, TNFSF11, EGF
40defense response to Gram-negative bacteriumGO:0508299.4TLR4, NOS2, IL6R, IL6, SERPINE1
41response to glucocorticoid stimulusGO:0513849.3SERPINE1, IL10, IL1B, IL1RN, TNF, CCL5
42cytokine-mediated signaling pathwayGO:0192219.3IL5, IL6, IL6R, IFNG, ICAM1, TNFSF11
43positive regulation of apoptotic processGO:0430659.2TP53, IL1B, TNF, BCL6, TLR4, MMP9
44platelet degranulationGO:0025768.8TGFB1, SOD1, TGFB2, SERPING1, SERPINE1, F5
45negative regulation of apoptotic processGO:0430668.7FGFR1, CSF2, DHRS2, TGFB2, TNF, TP53
46inflammatory responseGO:0069548.4MYD88, CCL11, CCL17, CCL5, CALCA, HRH1
47negative regulation of cell proliferationGO:0082858.1BCL6, TNF, TP53, TGFB2, SMAD2, DHRS2
48platelet activationGO:0301688.0TGFB2, IL6, ALB, TBXA2R, EGF, KNG1
49blood coagulationGO:0075967.4NOS2, SERPINC1, SELL, TP53, SERPINE1, TGFB2
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.8SMAD2, MYD88, SERPINE1, BMP6, CKAP2, MLL2

Molecular functions related to otitis media according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.7IL1RN, IL1B, IL1A, IRAK4
2growth factor activityGO:0080839.3CSF2, TGFB2, TGFB1, EGF, IL6, IL5
3protease bindingGO:0020209.1CSTA, ELANE, TNF, TP53, SERPINE1, SERPINC1
4heparin bindingGO:0082019.1KNG1, ELANE, LTF, CCL5, FGFR1, MPO
5receptor bindingGO:0051028.9KNG1, TGFB2, LTA, NOS2, CALCA, CCL17
6cytokine activityGO:0051258.8BMP6, CSF2, TGFB2, LTA, TNFSF11, TNFRSF11B
7protein bindingGO:0055153.8CTSL1, NR2F6, SMAD2, CRP, CRYGC, NOS1

Sources for Otitis Media

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z