MCID: OTT002
MIFTS: 59

Otitis Media malady

Ear diseases category
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Summaries for Otitis Media

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Wikipedia:65 Otitis media (Latin for \"inflammation of the middle ear\") is the medical term for middle-ear... more...

MalaCards: Otitis Media, also known as ear infection &/or otitis media nos, is related to influenza and meningitis. An important gene associated with Otitis Media is OMS (otitis media, susceptibility to), and among its related pathways are Defensins and Selected targets of GCR alpha. The compounds gluten and imipenem have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and brain, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A otitis which involves inflammation of the middle ear.

CDC:4 Español: Infecciones del oído

Aliases & Classifications for Otitis Media

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8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

otitis media 8 47 10 45
ear infection &/or otitis media nos 8
otitis media, susceptibility to 9
unspecified otitis media 8
infectious otitis media 62
otitis media nos 8


External Ids:

Disease Ontology8 DOID:10754
ICD9CM27 382.9
MeSH35 D010033
NCIt40 C34885

Related Diseases for Otitis Media

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Otitis Media via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.2CD79A, MBL2, CCL11
2meningitis31.1TLR2, MBL2, CD79A
3pneumonia31.1DEFB1, TLR2, HSF4, CCL11, MBL2, CD79A
4tonsillitis31.0DEFB1, CD79A
5sinusitis30.9CD79A, CCL11, RNASE3
6rhinitis30.8CD79A, CCL11, RNASE3
7tuberculosis30.8TLR2, MBL2, CD79A
8allergic rhinitis30.8RNASE3, CCL11
9common cold30.6CCL11, RNASE3
10conjunctivitis30.5CD79A, RNASE3
11atopy30.4TLR2, RNASE3, CCL11, CD14, CD79A
12asthma30.4DEFB1, TLR2, RNASE3, CCL11, MBL2, CD14
13vasculitis30.4MBL2, CD14, CD79A
14sarcoidosis30.3DEFB1, CCL11, CD14
15lymphadenitis30.3CD79A
16keratoconjunctivitis30.3RNASE3, CCL11
17bronchiolitis30.2RNASE3, CCL11
18peritonitis30.1TLR2, CD14
19inflammatory bowel disease30.0DEFB1, TLR2, CCL11, CD14
20suppurative otitis media11.5
21cholesteatoma11.0
22nasopharyngitis10.8
23adenoiditis10.7
24chronic purulent otitis media10.7
25otitis externa10.7
26non-suppurative otitis media10.7
27labyrinthitis10.7
28lateral sinus thrombosis10.7
29facial paralysis10.6
30acute serous otitis media10.6
31chronic adhesive otitis media10.6
32middle ear disease10.5
33tympanosclerosis10.5
34cleft palate10.5
35sensorineural hearing loss10.5
36purulent acute otitis media10.5
37chronic tubotympanic suppurative otitis media10.5
38scarlet fever10.4
39serous glue ear10.4
40chronic atticoantral disease10.4
41mycobacterium abscessus10.4
42pharyngitis10.4
43streptococcal meningitis10.4
44acute allergic serous otitis media10.4
45wegener's granulomatosis10.4
46acute allergic sanguinous otitis media10.4
47acute sanguinous otitis media10.4
48ankylosis10.3
49primary ciliary dyskinesia10.3
50cleft lip10.3

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Symptoms for Otitis Media

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Drugs & Therapeutics for Otitis Media

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Genetic Tests for Otitis Media

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Anatomical Context for Otitis Media

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33MalaCards
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MalaCards organs/tissues related to Otitis Media:

33
Bone, Tonsil, Brain, Testes, Colon, Endothelial, T cells, Temporal lobe, Myeloid, Skin, Lung, Pituitary

Animal Models for Otitis Media or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Otitis Media:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8DEFB1, TLR2, SERPINC1, MBL2, CD79A
2MP:00053977.3CD79A, CD14, MBL2, CCL11, SERPINC1, TLR2
3MP:00053876.7CD79A, CD14, MBL2, CCL11, SERPINC1, TLR2

Publications for Otitis Media

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Sources:
52PubMed
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Articles related to Otitis Media:

(show top 50)    (show all 1282)
idTitleAuthorsYear
1
Genetic contributors to otitis media: agnostic discovery approaches. (24415464)
2014
2
Intracranial complications of chronic otitis media. (24162767)
2013
3
Referrals for recurrent respiratory tract infections including otitis media in young children. (23566424)
2013
4
Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices. (24330917)
2013
5
Evolution of acute otitis media. (23599114)
2013
6
The point prevalence of otitis media with effusion in secondary school children in Pokhara, Nepal: a cross-sectional study. (23899700)
2013
7
Effect of low-intensity focused ultrasound on the middle ear in a mouse model of acute otitis media. (23312959)
2013
8
A review of the burden of disease due to otitis media in the Asia-Pacific. (22404948)
2012
9
Genetic susceptibility to otitis media in childhood. (22252840)
2012
10
Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. (22726871)
2012
11
Extended high frequency audiometry in secretory otitis media. (23730575)
2012
12
Computed tomography in chronic suppurative otitis media: value in surgical planning. (23998024)
2012
13
Mouse models of otitis media: strengths and limitations. (22661304)
2012
14
Role of nasopharyngeal reflux in the etiology of otitis media with effusion. (22420439)
2011
15
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
16
Antibiotics for acute otitis media in young children. (22085664)
2011
17
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
18
Refractory otitis media as the first manifestation of Wegener's granulomatosis. (20835547)
2010
19
Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. (19796826)
2009
20
Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. (18560870)
2009
21
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
22
Are antibiotics required for the treatment of acute serous otitis media in children? (19102064)
2008
23
Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media. (18008233)
2007
24
Comparison of cytokine levels in bilateral ear effusions in patients with otitis media secretoria. (17765774)
2007
25
Characterization of otitis media with effusion based on the ratio of albumin and immunoglobulin G concentrations in the effusion. (17667774)
2007
26
Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media. (17142509)
2006
27
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
28
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
29
Acute otitis media: making sense of recent guidelines on antimicrobial treatment. (15833221)
2005
30
Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial. (15839875)
2005
31
The role of allergy in the etiology of otitis media with effusion; immune system and cytokines. (16055981)
2004
32
Complement C3 cleavage and cytokines interleukin-1beta and tumor necrosis factor-alpha in otitis media with effusion. (11037838)
2000
33
Chronic suppurative otitis media in a children's hospital in Addis Ababa, Ethiopia. (11961874)
1999
34
Management of acute otitis media in an era of increasing antibiotic resistance. (10577768)
1999
35
Strategies for dealing with amoxicillin failure in acute otitis media. (9932075)
1999
36
Necrotizing otitis externa, otitis media, peripheral facial paralysis, and brain abscess in a thalassemic child after allogeneic BMT. (9783316)
1998
37
Treatment of otitis media with effusion in children with primary ciliary dyskinesia. (9298603)
1997
38
Classification of chronic suppurative otitis media: type III. (8870360)
1996
39
Interferon production by leukocytes in children with otitis media with effusion. (8770670)
1996
40
Epidemiology of chronic suppurative otitis media and deafness in a rural area and developing an intervention strategy. (10829951)
1995
41
Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. (8605906)
1995
42
Cochlear implants in chronic suppurative otitis media. (8588677)
1995
43
Otitis media due to blastomycosis: report of two cases. (1571452)
1992
44
Chronic suppurative otitis media in Sudanese patients. (2354676)
1990
45
Endolymphatic hydrops and otitis media. (423652)
1979
46
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. (1152752)
1975
47
Developmental variations of the temporal bone that influence the evolution of chronic suppurative otitis media and mastoiditis and the medical and surgical treatment of this syndrome. (4890239)
1969
48
Acute suppurative otitis media. (14825017)
1951
49
A study of chronic suppurative otitis media at the Pennsylvania School for the Deaf. (21023139)
1946
50
Streptococcal Meningitis secondary to Acute Suppurative Otitis Media: Simple Mastoidectomy. Recovery. (19990217)
1935

Variations for Otitis Media

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Expression for genes affiliated with Otitis Media

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Otitis Media

Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

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50PathCards, 55Reactome, 12EMD Millipore, 30KEGG, 53QIAGEN, 60Thomson Reuters
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Pathways related to Otitis Media according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4DEFB1, TLR2
29.3CCL11, TLR2
39.0CD14, TLR2
48.7CD14, MBL2, TLR2
5
Show member pathways
8.6CD79A, CD14, TLR2
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5CD14, CCL11, TLR2

Compounds for genes affiliated with Otitis Media

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Otitis Media according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1gluten4510.0CD79A, RNASE3
2imipenem459.9MBL2, SERPINC1
3anti-histamine459.8RNASE3, CCL11
4lte4459.7RNASE3, CCL11
5cetirizine45 29 24 1112.7CCL11, RNASE3
6sodium cromoglycate459.7CD79A, RNASE3, CCL11
7salbutamol45 51 29 24 1113.6RNASE3, CD79A, CCL11
8enterotoxin459.5RNASE3, CD79A, TLR2
9hbd2459.4TLR2, DEFB1
10tuberculin459.3CD14, MBL2, CD79A
11glucuronoxylomannan459.3TLR2, CD14
12leukotriene b445 61 2411.3CCL11, RNASE3, TLR2
13p003459.3MBL2, CD14, RNASE3
14anti-fungal459.2MBL2, RNASE3, TLR2, CD79A
15neopterin459.2CD79A, MBL2, CD14
16muramyl dipeptide45 2910.1TLR2, CD14
17pneumococcal459.1CD79A, CD14
18lipoteichoic acid459.1CD14, MBL2, TLR2
19aspirin45 51 29 2412.1CD79A, CCL11, SERPINC1, RNASE3
20n acetylcysteine459.1SERPINC1, CD79A, CCL11, RNASE3
21unicap458.9RNASE3, CCL11, CD14, CD79A
22zymosan458.9TLR2, MBL2, CD14, RNASE3
23methacholine45 51 1110.8CD14, CCL11, RNASE3, CD79A
24allergens458.8CD79A, CCL11, CD14, RNASE3
25estrogen458.8SHOX, SERPINC1, RNASE3, MBL2, CD79A
26latex458.8MBL2, TLR2, RNASE3, CD14
27mannan458.7MBL2, CD14, TLR2, CD79A
28carbohydrates458.7CD14, RNASE3, MBL2
29ethanol45 51 24 1111.7RNASE3, MBL2, TLR2, CD14
30polymyxin b458.7CD14, DEFB1, TLR2, MBL2
31mannose458.7CD14, CD79A, MBL2, TLR2
32vitamin d458.6CD79A, MBL2, CD14, TLR2
33peptidoglycan45 299.6TLR2, CCL11, CD14, MBL2
34endotoxin458.6RNASE3, CCL11, CD14, TLR2
35prednisolone45 29 1110.5CD79A, CD14, MBL2, CCL11, RNASE3
36creatinine458.5MBL2, CD79A, CD14, RNASE3, SERPINC1
37superoxide45 249.3TLR2, CD14, MBL2, CCL11
38heparin45 29 24 1111.3CD79A, CCL11, SERPINC1, CD14, RNASE3
39histamine45 29 2410.2CD79A, CD14, CCL11, RNASE3, TLR2
40cyclosporin a45 29 6110.2CD79A, RNASE3, CCL11, CD14, TLR2
41steroid458.2RNASE3, CD79A, CD14, MBL2, CCL11, SHOX
42arginine458.1CD14, SERPINC1, TLR2, CD79A, RNASE3
43polysaccharide457.9MBL2, TLR2, CD79A, SERPINC1, CD14, RNASE3
44fibrinogen457.9CD14, MBL2, CD79A, RNASE3, SERPINC1, TLR2
45rantes457.9CD14, CCL11, RNASE3, TLR2, DEFB1, MBL2
46alanine457.9SERPINC1, CD79A, TLR2, CCL11, CD14
47retinoic acid45 248.7CD79A, CD14, CCL11, RNASE3, TLR2, DEFB1
48pge2457.7CD79A, TLR2, SERPINC1, RNASE3, CCL11, CD14
49vegf457.4CD79A, RNASE3, TLR2, SERPINC1, CD14, MBL2
50dexamethasone45 51 29 119.9CD79A, MBL2, CCL11, RNASE3, SERPINC1, TLR2

GO Terms for genes affiliated with Otitis Media

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16Gene Ontology
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Cellular components related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4TLR2, MBL2, CD14
2extracellular spaceGO:0056158.3CD14, MBL2, CCL11, SERPINC1
3extracellular regionGO:0055767.4CD14, MBL2, CCL11, RNASE3, SERPINC1, DEFB1

Biological processes related to Otitis Media according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.7TLR2, MBL2
2defense response to bacteriumGO:0427429.6MBL2, RNASE3, DEFB1
3defense response to Gram-positive bacteriumGO:0508309.5MBL2, TLR2
4cellular response to lipoteichoic acidGO:0712239.2CD14, TLR2
5positive regulation of cytokine secretionGO:0507159.1TLR2, CD14
6positive regulation of tumor necrosis factor productionGO:0327608.9CD14, TLR2
7immune responseGO:0069558.9CCL11, TLR2, DEFB1
8innate immune responseGO:0450878.4CD14, MBL2, TLR2, DEFB1
9inflammatory responseGO:0069548.2TLR2, CCL11, CD14

Molecular functions related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:0708919.0CD14, TLR2

Products for genes affiliated with Otitis Media

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Sources for Otitis Media

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet