MCID: OTT002
MIFTS: 56

Otitis Media malady

Ear diseases, Bone diseases categories

Summaries for Otitis Media

About this section


Wikipedia:63 Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

MalaCards based summary: Otitis Media, also known as otitis media, susceptibility to, is related to tonsillitis and meningitis, and has symptoms including recurrent otitis mediaand familial predisposition. An important gene associated with Otitis Media is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Defensins and Legionellosis. The drugs sulfisoxazole and sulfisoxazole diolamine and the compounds sodium cromoglycate and enterotoxin have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and brain, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Disease Ontology:9 A otitis which involves inflammation of the middle ear.

Aliases & Classifications for Otitis Media

About this section

Otitis Media, Aliases & Descriptions:

Name: Otitis Media 9 11 43 3 60
Otitis Media, Susceptibility to 10
 
Infectious Otitis Media 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases, Bone diseases


External Ids:

Disease Ontology9 DOID:10754
ICD9CM27 382.9
MeSH33 D010033
NCIt38 C34885
ICD1025 H67, H67.8

Related Diseases for Otitis Media

About this section

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 351)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis31.4DEFB1, CD79A
2meningitis31.3CD79A, MBL2, TLR2
3influenza31.2LTF, CD79A, MBL2, CCL11
4sinusitis31.1RNASE3, CCL11, CD79A
5allergic rhinitis31.1RNASE3, CCL11
6rhinitis31.1RNASE3, CCL11, CD79A
7common cold31.0CCL11, RNASE3
8conjunctivitis31.0CD79A, RNASE3
9parotitis30.9HSF4
10lymphadenitis30.9CD79A
11tuberculosis30.9CD79A, MBL2, TLR2
12keratoconjunctivitis sicca30.8LTF
13pneumonia30.7DEFB1, TLR2, HSF4, CCL11, MBL2, CD79A
14keratoconjunctivitis30.6RNASE3, CCL11
15churg-strauss syndrome30.6RNASE3, LTF
16common variable immunodeficiency30.6CD79A, MBL2
17bronchiolitis30.6CCL11, RNASE3
18dermatitis30.5RNASE3, CD14
19chorioamnionitis30.4TLR2, LTF
20vasculitis30.3MBL2, CD14, CD79A, LTF
21atopy30.2TLR2, RNASE3, CCL11, CD14, CD79A
22peritonitis30.0CD14, TLR2
23asthma29.8DEFB1, TLR2, RNASE3, CCL11, MBL2, CD14
24inflammatory bowel disease29.5DEFB1, TLR2, CCL11, CD14, LTF
25suppurative otitis media11.5
26cholesteatoma11.0
27haemophilus influenzae10.8
28nasopharyngitis10.8
29adenoiditis10.7
30chronic purulent otitis media10.7
31otitis externa10.7
32labyrinthitis10.7
33non-suppurative otitis media10.7
34lateral sinus thrombosis10.7
35facial paralysis10.6
36acute serous otitis media10.6
37chronic adhesive otitis media10.6
38tympanosclerosis10.6
39collagenous colitis10.6RNASE3
40sensorineural hearing loss10.5
41middle ear disease10.5
42rheumatic fever10.5MBL2
43purulent acute otitis media10.5
44chronic tubotympanic suppurative otitis media10.5
45urethritis10.5CD79A
46q fever10.5CD79A
47poems syndrome10.5CD79A
48brucellosis10.5CD79A
49exanthem10.5CD79A
50malaria10.4TLR2

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Symptoms for Otitis Media

About this section

HPO human phenotypes related to Otitis Media:

id Description Frequency HPO Source Accession
1 recurrent otitis media HP:0000403
2 familial predisposition HP:0001472

Drugs & Therapeutics for Otitis Media

About this section

Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Otitis Media

About this section

Anatomical Context for Otitis Media

About this section

MalaCards organs/tissues related to Otitis Media:

31
Bone, Tonsil, Brain, Neutrophil, Testes, Colon, Skin, T cells, Endothelial, Temporal lobe, Lung, Myeloid, Pituitary

Animal Models for Otitis Media or affiliated genes

About this section

MGI Mouse Phenotypes related to Otitis Media:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7DEFB1, TLR2, SERPINC1, MBL2, CD79A
2MP:00053767.3LTF, CD79A, CD14, MBL2, SERPINC1, TLR2
3MP:00053976.8TLR2, SERPINC1, CCL11, MBL2, CD14, CD79A
4MP:00053876.4LTF, DEFB1, TLR2, SERPINC1, CCL11, MBL2

Publications for Otitis Media

About this section

Articles related to Otitis Media:

(show top 50)    (show all 1355)
idTitleAuthorsYear
1
Phialemonium infection complicating chronic suppurative otitis media. (24596671)
2014
2
A mistaken identity: rhabdomyosarcoma of the middle ear cleft misdiagnosed as chronic suppurative otitis media with temporal lobe abscess. (25240007)
2014
3
Volume of the Epitympanum and Blockage of the Tympanic Isthmus in Chronic Otitis Media: A Human Temporal Bone Study. (25325843)
2014
4
Preparation of levofloxacin thermo-sensitive gel and clinical application in the treatment of suppurative otitis media. (24597493)
2014
5
Intracranial complications of chronic otitis media. (24162767)
2013
6
Referrals for recurrent respiratory tract infections including otitis media in young children. (23566424)
2013
7
Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices. (24330917)
2013
8
Evolution of acute otitis media. (23599114)
2013
9
The point prevalence of otitis media with effusion in secondary school children in Pokhara, Nepal: a cross-sectional study. (23899700)
2013
10
Effect of low-intensity focused ultrasound on the middle ear in a mouse model of acute otitis media. (23312959)
2013
11
A review of the burden of disease due to otitis media in the Asia-Pacific. (22404948)
2012
12
Genetic susceptibility to otitis media in childhood. (22252840)
2012
13
Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. (22726871)
2012
14
Extended high frequency audiometry in secretory otitis media. (23730575)
2012
15
Computed tomography in chronic suppurative otitis media: value in surgical planning. (23998024)
2012
16
Role of nasopharyngeal reflux in the etiology of otitis media with effusion. (22420439)
2011
17
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
18
Antibiotics for acute otitis media in young children. (22085664)
2011
19
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
20
Refractory otitis media as the first manifestation of Wegener's granulomatosis. (20835547)
2010
21
Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. (19796826)
2009
22
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
23
Are antibiotics required for the treatment of acute serous otitis media in children? (19102064)
2008
24
Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media. (18008233)
2007
25
Comparison of cytokine levels in bilateral ear effusions in patients with otitis media secretoria. (17765774)
2007
26
Characterization of otitis media with effusion based on the ratio of albumin and immunoglobulin G concentrations in the effusion. (17667774)
2007
27
Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media. (17142509)
2006
28
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
29
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
30
Acute otitis media: making sense of recent guidelines on antimicrobial treatment. (15833221)
2005
31
Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial. (15839875)
2005
32
The role of allergy in the etiology of otitis media with effusion; immune system and cytokines. (16055981)
2004
33
Complement C3 cleavage and cytokines interleukin-1beta and tumor necrosis factor-alpha in otitis media with effusion. (11037838)
2000
34
Chronic suppurative otitis media in a children's hospital in Addis Ababa, Ethiopia. (11961874)
1999
35
Management of acute otitis media in an era of increasing antibiotic resistance. (10577768)
1999
36
Strategies for dealing with amoxicillin failure in acute otitis media. (9932075)
1999
37
Necrotizing otitis externa, otitis media, peripheral facial paralysis, and brain abscess in a thalassemic child after allogeneic BMT. (9783316)
1998
38
Treatment of otitis media with effusion in children with primary ciliary dyskinesia. (9298603)
1997
39
Classification of chronic suppurative otitis media: type III. (8870360)
1996
40
Interferon production by leukocytes in children with otitis media with effusion. (8770670)
1996
41
Epidemiology of chronic suppurative otitis media and deafness in a rural area and developing an intervention strategy. (10829951)
1995
42
Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. (8605906)
1995
43
Cochlear implants in chronic suppurative otitis media. (8588677)
1995
44
Otitis media due to blastomycosis: report of two cases. (1571452)
1992
45
Chronic suppurative otitis media in Sudanese patients. (2354676)
1990
46
Endolymphatic hydrops and otitis media. (423652)
1979
47
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. (1152752)
1975
48
Developmental variations of the temporal bone that influence the evolution of chronic suppurative otitis media and mastoiditis and the medical and surgical treatment of this syndrome. (4890239)
1969
49
A study of chronic suppurative otitis media at the Pennsylvania School for the Deaf. (21023139)
1946
50
Streptococcal Meningitis secondary to Acute Suppurative Otitis Media: Simple Mastoidectomy. Recovery. (19990217)
1935

Variations for Otitis Media

About this section

Expression for genes affiliated with Otitis Media

About this section
Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

About this section

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR2, DEFB1
29.3CD14, TLR2
39.0CD14, MBL2, TLR2
4
Show member pathways
9.0CD79A, CD14, TLR2
5
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.9CD14, CCL11, TLR2

Compounds for genes affiliated with Otitis Media

About this section

Compounds related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1sodium cromoglycate439.7CD79A, CCL11, RNASE3
2enterotoxin439.6TLR2, RNASE3, CD79A
3tuberculin439.5CD79A, CD14, MBL2
4salbutamol43 49 28 24 1213.5CD79A, CCL11, RNASE3
5clarithromycin43 1210.5LTF, CD79A, CCL11
6budesonide43 49 1211.4RNASE3, CCL11, LTF
7percoll439.3RNASE3, CD14, LTF
8pneumococcal439.3LTF, CD79A, CD14
9n-formylmethionyl-leucylphenylalanine439.2RNASE3, CCL11, LTF
10lipoteichoic acid439.2TLR2, MBL2, CD14
11unicap439.2RNASE3, CCL11, CD14, CD79A
12hyaluronic acid43 2410.1LTF, CD79A, CCL11, RNASE3
13allergens439.1RNASE3, CCL11, CD14, CD79A
14mannan439.1CD79A, CD14, MBL2, TLR2
15carbohydrates439.1RNASE3, MBL2, CD14, LTF
16neopterin439.0LTF, CD79A, CD14, MBL2
17leukotriene b443 59 2411.0TLR2, RNASE3, CCL11, LTF
18peptidoglycan43 2810.0TLR2, CCL11, MBL2, CD14
19anti-fungal438.9TLR2, RNASE3, MBL2, CD79A, LTF
20nacl438.9DEFB1, CCL11, MBL2, LTF
21phosphatidylserine43 28 1210.9LTF, CD79A, CD14, MBL2
22prednisolone43 28 1210.9RNASE3, CCL11, MBL2, CD14, CD79A
23fmlp438.8LTF, CD14, CCL11, RNASE3
24zymosan438.7TLR2, RNASE3, MBL2, CD14, LTF
25methacholine43 49 1210.7RNASE3, CCL11, CD14, CD79A, LTF
26latex438.6TLR2, RNASE3, MBL2, CD14, LTF
27aspirin43 49 28 2411.6CD79A, CCL11, RNASE3, SERPINC1
28vitamin d438.6CD79A, CD14, MBL2, TLR2
29polymyxin b438.5LTF, CD14, MBL2, TLR2, DEFB1
30mannose438.5TLR2, MBL2, CD14, CD79A, LTF
31steroid438.5SHOX, RNASE3, CCL11, MBL2, CD14, CD79A
32endotoxin438.5TLR2, RNASE3, CCL11, CD14, LTF
33heparan sulfate43 249.5LTF, SERPINC1, TLR2, DEFB1
34ethanol43 49 24 1211.4TLR2, RNASE3, MBL2, CD14
35n acetylcysteine438.4SERPINC1, RNASE3, CCL11, CD79A, LTF
36superoxide43 249.4TLR2, CCL11, MBL2, CD14, LTF
37rantes438.3DEFB1, TLR2, RNASE3, CCL11, MBL2, CD14
38estrogen438.2SHOX, SERPINC1, RNASE3, MBL2, CD79A, LTF
39histamine43 28 2410.1TLR2, RNASE3, CCL11, CD14, CD79A, LTF
40cyclosporin a43 28 5910.1TLR2, RNASE3, CCL11, CD14, CD79A, LTF
41creatinine438.0SERPINC1, RNASE3, MBL2, CD14, CD79A, LTF
42arginine437.9CD79A, CD14, RNASE3, SERPINC1, TLR2
43heparin43 28 24 1210.8SERPINC1, RNASE3, CCL11, CD14, CD79A, LTF
44retinoic acid43 248.7DEFB1, TLR2, RNASE3, CCL11, CD14, CD79A
45alanine437.5TLR2, SERPINC1, CCL11, CD14, CD79A, LTF
46polysaccharide437.5TLR2, SERPINC1, RNASE3, MBL2, CD14, CD79A
47fibrinogen437.5TLR2, SERPINC1, RNASE3, MBL2, CD14, CD79A
48pge2437.3TLR2, SERPINC1, RNASE3, CCL11, CD14, CD79A
49vegf437.0TLR2, SERPINC1, RNASE3, CCL11, MBL2, CD14
50dexamethasone43 49 28 129.6LTF, DEFB1, TLR2, SERPINC1, RNASE3, CCL11

GO Terms for genes affiliated with Otitis Media

About this section

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.0CD14, MBL2, TLR2
2extracellular spaceGO:00056157.5SERPINC1, CCL11, MBL2, CD14, LTF
3extracellular regionGO:00055767.0LTF, CD14, MBL2, CCL11, RNASE3, SERPINC1

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:00441309.8TLR2, MBL2
2defense response to bacteriumGO:00427429.7MBL2, RNASE3, DEFB1
3defense response to Gram-positive bacteriumGO:00508309.7MBL2, TLR2
4cellular response to lipoteichoic acidGO:00712239.5CD14, TLR2
5positive regulation of cytokine secretionGO:00507159.4TLR2, CD14
6positive regulation of tumor necrosis factor productionGO:00327609.2CD14, TLR2
7immune responseGO:00069559.1CCL11, TLR2, DEFB1
8innate immune responseGO:00450878.7CD14, MBL2, TLR2, DEFB1
9inflammatory responseGO:00069548.6TLR2, CCL11, CD14

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:00708919.3CD14, TLR2

Products for genes affiliated with Otitis Media

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Otitis Media

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet