MCID: OTT002
MIFTS: 58

Otitis Media malady

Ear diseases category
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Summaries for Otitis Media

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Wikipedia:65 Otitis media (Latin for \"inflammation of the middle ear\") or tympanitis is the medical term for middle... more...

MalaCards based summary: Otitis Media, also known as otitis media, susceptibility to, is related to influenza and tonsillitis, and has symptoms including An important gene associated with Otitis Media is OMS (otitis media, susceptibility to), and among its related pathways are Defensins and Selected targets of GCR alpha. The compounds gluten and imipenem have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and brain, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A otitis which involves inflammation of the middle ear.

CDC:3 EspaƱol: Infecciones del oƭdo

Aliases & Classifications for Otitis Media

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Otitis Media, Aliases & Descriptions:

Name: Otitis Media 8 46 10 44
Otitis Media, Susceptibility to 9
 
Infectious Otitis Media 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


External Ids:

Disease Ontology8 DOID:10754
MeSH34 D010033
NCIt39 C34885
ICD9CM27 382.9

Related Diseases for Otitis Media

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Diseases related to Otitis Media via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.4CD79A, MBL2, CCL11
2tonsillitis31.4DEFB1, CD79A
3meningitis31.2TLR2, MBL2, CD79A
4allergic rhinitis31.1RNASE3, CCL11
5sinusitis31.1CD79A, CCL11, RNASE3
6rhinitis31.0CD79A, CCL11, RNASE3
7common cold31.0CCL11, RNASE3
8conjunctivitis31.0CD79A, RNASE3
9parotitis30.9HSF4
10lymphadenitis30.9CD79A
11tuberculosis30.9TLR2, MBL2, CD79A
12keratoconjunctivitis30.6RNASE3, CCL11
13pneumonia30.6DEFB1, TLR2, HSF4, CCL11, MBL2, CD79A
14bronchiolitis30.6RNASE3, CCL11
15vasculitis30.5MBL2, CD14, CD79A
16sarcoidosis30.2DEFB1, CCL11, CD14
17peritonitis30.0TLR2, CD14
18atopy29.9TLR2, RNASE3, CCL11, CD14, CD79A
19inflammatory bowel disease29.6DEFB1, TLR2, CCL11, CD14
20asthma29.5DEFB1, TLR2, RNASE3, CCL11, MBL2, CD14
21suppurative otitis media11.5
22cholesteatoma11.0
23haemophilus influenzae10.8
24nasopharyngitis10.8
25chronic purulent otitis media10.8
26adenoiditis10.7
27otitis externa10.7
28labyrinthitis10.7
29non-suppurative otitis media10.7
30lateral sinus thrombosis10.7
31facial paralysis10.7
32chronic adhesive otitis media10.6
33acute serous otitis media10.6
34tympanosclerosis10.6
35cleft palate10.6
36sensorineural hearing loss10.6
37middle ear disease10.6
38rheumatic fever10.5MBL2
39collagenous colitis10.5RNASE3
40chronic tubotympanic suppurative otitis media10.5
41purulent acute otitis media10.5
42q fever10.5CD79A
43poems syndrome10.5CD79A
44brucellosis10.5CD79A
45exanthem10.5CD79A
46chronic atticoantral disease10.5
47wegener's granulomatosis10.5
48scarlet fever10.5
49serous glue ear10.5
50mycobacterium abscessus10.5

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Symptoms for Otitis Media

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HPO human phenotypes related to Otitis Media:

id Description Frequency HPO Source Accession
1 recurrent otitis media HP:0000403
2 familial predisposition HP:0001472

Drugs & Therapeutics for Otitis Media

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Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Genetic Tests for Otitis Media

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Anatomical Context for Otitis Media

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MalaCards organs/tissues related to Otitis Media:

32
Bone, Tonsil, Brain, Neutrophil, Testes, Colon, T cells, Endothelial, Temporal lobe, Lung, Skin, Myeloid, Pituitary

Animal Models for Otitis Media or affiliated genes

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MGI Mouse Phenotypes related to Otitis Media:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8DEFB1, TLR2, SERPINC1, MBL2, CD79A
2MP:00053977.3CD79A, CD14, MBL2, CCL11, SERPINC1, TLR2
3MP:00053876.7CD79A, CD14, MBL2, CCL11, SERPINC1, TLR2

Publications for Otitis Media

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Articles related to Otitis Media:

(show top 50)    (show all 1319)
idTitleAuthorsYear
1
Phialemonium infection complicating chronic suppurative otitis media. (24596671)
2014
2
A mistaken identity: rhabdomyosarcoma of the middle ear cleft misdiagnosed as chronic suppurative otitis media with temporal lobe abscess. (25240007)
2014
3
Volume of the Epitympanum and Blockage of the Tympanic Isthmus in Chronic Otitis Media: A Human Temporal Bone Study. (25325843)
2014
4
Preparation of levofloxacin thermo-sensitive gel and clinical application in the treatment of suppurative otitis media. (24597493)
2014
5
Intracranial complications of chronic otitis media. (24162767)
2013
6
Referrals for recurrent respiratory tract infections including otitis media in young children. (23566424)
2013
7
Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices. (24330917)
2013
8
Evolution of acute otitis media. (23599114)
2013
9
The point prevalence of otitis media with effusion in secondary school children in Pokhara, Nepal: a cross-sectional study. (23899700)
2013
10
Effect of low-intensity focused ultrasound on the middle ear in a mouse model of acute otitis media. (23312959)
2013
11
A review of the burden of disease due to otitis media in the Asia-Pacific. (22404948)
2012
12
Genetic susceptibility to otitis media in childhood. (22252840)
2012
13
Bacterial biofilms in the upper airway - evidence for role in pathology and implications for treatment of otitis media. (22726871)
2012
14
Extended high frequency audiometry in secretory otitis media. (23730575)
2012
15
Computed tomography in chronic suppurative otitis media: value in surgical planning. (23998024)
2012
16
Role of nasopharyngeal reflux in the etiology of otitis media with effusion. (22420439)
2011
17
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not. (20875194)
2011
18
Antibiotics for acute otitis media in young children. (22085664)
2011
19
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
20
Refractory otitis media as the first manifestation of Wegener's granulomatosis. (20835547)
2010
21
Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. (19796826)
2009
22
Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. (18560870)
2009
23
Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study. (18760552)
2008
24
Are antibiotics required for the treatment of acute serous otitis media in children? (19102064)
2008
25
Antibodies to pneumococcal surface protein A families 1 and 2 in serum and saliva of children and the risk of pneumococcal acute otitis media. (18008233)
2007
26
Comparison of cytokine levels in bilateral ear effusions in patients with otitis media secretoria. (17765774)
2007
27
Characterization of otitis media with effusion based on the ratio of albumin and immunoglobulin G concentrations in the effusion. (17667774)
2007
28
Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media. (17142509)
2006
29
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
30
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
31
Acute otitis media: making sense of recent guidelines on antimicrobial treatment. (15833221)
2005
32
Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial. (15839875)
2005
33
The role of allergy in the etiology of otitis media with effusion; immune system and cytokines. (16055981)
2004
34
Complement C3 cleavage and cytokines interleukin-1beta and tumor necrosis factor-alpha in otitis media with effusion. (11037838)
2000
35
Chronic suppurative otitis media in a children's hospital in Addis Ababa, Ethiopia. (11961874)
1999
36
Management of acute otitis media in an era of increasing antibiotic resistance. (10577768)
1999
37
Strategies for dealing with amoxicillin failure in acute otitis media. (9932075)
1999
38
Necrotizing otitis externa, otitis media, peripheral facial paralysis, and brain abscess in a thalassemic child after allogeneic BMT. (9783316)
1998
39
Treatment of otitis media with effusion in children with primary ciliary dyskinesia. (9298603)
1997
40
Classification of chronic suppurative otitis media: type III. (8870360)
1996
41
Interferon production by leukocytes in children with otitis media with effusion. (8770670)
1996
42
Epidemiology of chronic suppurative otitis media and deafness in a rural area and developing an intervention strategy. (10829951)
1995
43
Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. (8605906)
1995
44
Cochlear implants in chronic suppurative otitis media. (8588677)
1995
45
Otitis media due to blastomycosis: report of two cases. (1571452)
1992
46
Chronic suppurative otitis media in Sudanese patients. (2354676)
1990
47
Endolymphatic hydrops and otitis media. (423652)
1979
48
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. (1152752)
1975
49
Developmental variations of the temporal bone that influence the evolution of chronic suppurative otitis media and mastoiditis and the medical and surgical treatment of this syndrome. (4890239)
1969
50
A study of chronic suppurative otitis media at the Pennsylvania School for the Deaf. (21023139)
1946

Variations for Otitis Media

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Expression for genes affiliated with Otitis Media

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Expression patterns in normal tissues for genes affiliated with Otitis Media

Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

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Pathways related to Otitis Media according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4DEFB1, TLR2
29.3CCL11, TLR2
39.0CD14, TLR2
48.7CD14, MBL2, TLR2
5
Show member pathways
8.6CD79A, CD14, TLR2
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5CD14, CCL11, TLR2

Compounds for genes affiliated with Otitis Media

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Compounds related to Otitis Media according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1gluten4410.0CD79A, RNASE3
2imipenem449.9MBL2, SERPINC1
3anti-histamine449.8RNASE3, CCL11
4lte4449.7RNASE3, CCL11
5cetirizine44 28 24 1112.7CCL11, RNASE3
6sodium cromoglycate449.7CD79A, RNASE3, CCL11
7salbutamol44 50 28 24 1113.6RNASE3, CD79A, CCL11
8enterotoxin449.5RNASE3, CD79A, TLR2
9hbd2449.4TLR2, DEFB1
10tuberculin449.3CD14, MBL2, CD79A
11glucuronoxylomannan449.3TLR2, CD14
12leukotriene b444 61 2411.3CCL11, RNASE3, TLR2
13p003449.3MBL2, CD14, RNASE3
14anti-fungal449.2MBL2, RNASE3, TLR2, CD79A
15neopterin449.2CD79A, MBL2, CD14
16muramyl dipeptide44 2810.1TLR2, CD14
17pneumococcal449.1CD79A, CD14
18lipoteichoic acid449.1CD14, MBL2, TLR2
19aspirin44 50 28 2412.1CD79A, CCL11, SERPINC1, RNASE3
20n acetylcysteine449.1SERPINC1, CD79A, CCL11, RNASE3
21unicap448.9RNASE3, CCL11, CD14, CD79A
22zymosan448.9TLR2, MBL2, CD14, RNASE3
23methacholine44 50 1110.8CD14, CCL11, RNASE3, CD79A
24allergens448.8CD79A, CCL11, CD14, RNASE3
25estrogen448.8SHOX, SERPINC1, RNASE3, MBL2, CD79A
26latex448.8MBL2, TLR2, RNASE3, CD14
27mannan448.7MBL2, CD14, TLR2, CD79A
28carbohydrates448.7CD14, RNASE3, MBL2
29ethanol44 50 24 1111.7RNASE3, MBL2, TLR2, CD14
30polymyxin b448.7CD14, DEFB1, TLR2, MBL2
31mannose448.7CD14, CD79A, MBL2, TLR2
32vitamin d448.6CD79A, MBL2, CD14, TLR2
33peptidoglycan44 289.6TLR2, CCL11, CD14, MBL2
34endotoxin448.6RNASE3, CCL11, CD14, TLR2
35prednisolone44 28 1110.5CD79A, CD14, MBL2, CCL11, RNASE3
36creatinine448.5MBL2, CD79A, CD14, RNASE3, SERPINC1
37superoxide44 249.3TLR2, CD14, MBL2, CCL11
38heparin44 28 24 1111.3CD79A, CCL11, SERPINC1, CD14, RNASE3
39histamine44 28 2410.2CD79A, CD14, CCL11, RNASE3, TLR2
40cyclosporin a44 28 6110.2CD79A, RNASE3, CCL11, CD14, TLR2
41steroid448.2RNASE3, CD79A, CD14, MBL2, CCL11, SHOX
42arginine448.1CD14, SERPINC1, TLR2, CD79A, RNASE3
43polysaccharide447.9MBL2, TLR2, CD79A, SERPINC1, CD14, RNASE3
44fibrinogen447.9CD14, MBL2, CD79A, RNASE3, SERPINC1, TLR2
45rantes447.9CD14, CCL11, RNASE3, TLR2, DEFB1, MBL2
46alanine447.9SERPINC1, CD79A, TLR2, CCL11, CD14
47retinoic acid44 248.7CD79A, CD14, CCL11, RNASE3, TLR2, DEFB1
48pge2447.7CD79A, TLR2, SERPINC1, RNASE3, CCL11, CD14
49vegf447.4CD79A, RNASE3, TLR2, SERPINC1, CD14, MBL2
50dexamethasone44 50 28 119.9CD79A, MBL2, CCL11, RNASE3, SERPINC1, TLR2

GO Terms for genes affiliated with Otitis Media

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Cellular components related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4TLR2, MBL2, CD14
2extracellular spaceGO:0056158.3CD14, MBL2, CCL11, SERPINC1
3extracellular regionGO:0055767.4CD14, MBL2, CCL11, RNASE3, SERPINC1, DEFB1

Biological processes related to Otitis Media according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.7TLR2, MBL2
2defense response to bacteriumGO:0427429.6MBL2, RNASE3, DEFB1
3defense response to Gram-positive bacteriumGO:0508309.5MBL2, TLR2
4cellular response to lipoteichoic acidGO:0712239.2CD14, TLR2
5positive regulation of cytokine secretionGO:0507159.1TLR2, CD14
6positive regulation of tumor necrosis factor productionGO:0327608.9CD14, TLR2
7immune responseGO:0069558.9CCL11, TLR2, DEFB1
8innate immune responseGO:0450878.4CD14, MBL2, TLR2, DEFB1
9inflammatory responseGO:0069548.2TLR2, CCL11, CD14

Molecular functions related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:0708919.0CD14, TLR2

Products for genes affiliated with Otitis Media

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Sources for Otitis Media

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet