Aliases & Classifications for Otitis Media

MalaCards integrated aliases for Otitis Media:

Name: Otitis Media 53 12 28 51 3 41 14 69
Otitis Media, Susceptibility to 53 13
Otitis Media, Chronic/recurrent 53
Infectious Otitis Media 69
Come/rom 53
Oms 53

Characteristics:

OMIM:

53
Inheritance:
familial predisposition


HPO:

31
otitis media:
Inheritance familial predisposition


Classifications:



External Ids:

OMIM 53 166760
Disease Ontology 12 DOID:10754
ICD10 32 H66.9 H66.90
ICD9CM 34 382.9
MeSH 41 D010033
NCIt 46 C34885
MedGen 39 C1833692

Summaries for Otitis Media

Disease Ontology : 12 A otitis which involves inflammation of the middle ear.

MalaCards based summary : Otitis Media, also known as otitis media, susceptibility to, is related to suppurative otitis media and haemophilus influenzae, and has symptoms including recurrent otitis media An important gene associated with Otitis Media is OMS (Otitis Media, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cedax and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

Description from OMIM: 166760

Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 522)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 34.8 IL1B TLR2 TLR4
2 haemophilus influenzae 31.2 CXCL8 IL1B TLR2 TNF
3 mycobacterium abscessus 30.8 CXCL8 TLR2 TNF
4 mycobacterium fortuitum 30.7 CXCL8 LACTB
5 mycobacterium chelonae 30.6 CXCL8 TLR2
6 tonsillitis 30.6 CD79A CXCL8 IL1B IL6 TNF
7 septic arthritis 30.6 CXCL8 TLR2 TLR4
8 ige responsiveness, atopic 30.5 IGHE IL10 RNASE3
9 wegener granulomatosis 30.4 CXCL8 IL10 IL6 TNF
10 rhinitis 30.3 CCL11 CXCL8 IGHE RNASE3
11 fasciitis 30.3 CXCL8 IL6 TNF
12 streptococcal meningitis 30.3 CD40LG MBL2 TNF
13 common cold 30.3 CCL11 CXCL8 RNASE3
14 arthritis 30.2 CXCL8 IL10 IL1B IL6 TNF
15 mycobacterium tuberculosis 1 30.2 IL10 MBL2 TLR2 TLR4 TNF
16 osteomyelitis 30.2 CXCL8 IL10 IL1B IL6 TNF
17 extrapulmonary tuberculosis 30.1 IL10 IL1B TLR2
18 aseptic meningitis 30.1 CXCL8 IL10 IL1B TNF
19 cytomegalovirus infection 30.0 CXCL8 IL10 IL6 TNF
20 meningoencephalitis 30.0 CD40LG CD79A IL6
21 conjunctivitis 30.0 CCL11 CXCL8 IL6 RNASE3
22 chorioamnionitis 29.9 CXCL8 IL1B IL6 TLR4 TNF
23 allergic rhinitis 29.9 CCL11 CXCL8 IGHE IL10 RNASE3
24 listeriosis 29.9 IL10 IL6 MBL2 TNF
25 lymphadenitis 29.8 CXCL8 IL10 IL1B TLR4 TNF
26 helicobacter pylori infection 29.8 CXCL8 IL10 IL1B TLR4 TNF
27 appendicitis 29.8 CXCL8 IL10 IL1B IL6 TNF
28 reactive arthritis 29.8 CD79A IL10 IL6 TNF
29 pneumocystosis 29.8 CD40LG CD79A TNF
30 keratoconjunctivitis sicca 29.7 CD79A IL1B IL6 TLR4 TNF
31 churg-strauss syndrome 29.7 CD40LG IL10 RNASE3 TNF
32 allergic hypersensitivity disease 29.6 CCL11 IGHE IL10 RNASE3
33 lyme disease 29.5 CD40LG IL1B IL6 TLR2 TNF
34 bacterial meningitis 29.5 CXCL8 IL10 IL1B IL6 TLR2 TNF
35 peritonitis 29.5 CXCL8 IL10 IL1B IL6 TLR2 TNF
36 keratoconjunctivitis 29.3 CCL11 CD79A CXCL8 RNASE3 TNF
37 meningitis 29.2 CD40LG CXCL8 IL10 IL1B IL6 LACTB
38 crohn's disease 29.1 IL10 IL1B IL6 MUC2 TLR4 TNF
39 bronchitis 28.8 CCL11 CD40LG CD79A CXCL8 RNASE3 TNF
40 middle ear disease 28.5 A2ML1 CD40LG CD79A CXCL8 FBXO11 IL1B
41 pneumonia 28.2 CCL11 CD40LG CXCL8 IL10 IL1B IL6
42 asthma 27.9 CCL11 CD40LG CD79A CXCL8 IGHE IL10
43 bronchiolitis 27.7 CCL11 CD40LG CXCL8 IGHE IL10 IL6
44 inflammatory bowel disease 27.5 CCL11 CD79A CXCL8 IL10 IL1B IL6
45 acute serous otitis media 12.7
46 non-suppurative otitis media 12.6
47 chronic purulent otitis media 12.6
48 purulent acute otitis media 12.6
49 chronic tubotympanic suppurative otitis media 12.5
50 acute allergic serous otitis media 12.4

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Bronchitis
Cholesteatoma of Middle Ear Chronic Myocardial Ischemia
Deficiency Anemia Heart Disease
Hypertension, Essential Labyrinthitis
Mastoiditis Otitis Externa
Pneumococcal Meningitis

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to Otitis Media

Symptoms & Phenotypes for Otitis Media

Symptoms via clinical synopsis from OMIM:

53
Ears:
susceptibility to otitis media


Clinical features from OMIM:

166760

Human phenotypes related to Otitis Media:

31
# Description HPO Frequency HPO Source Accession
1 recurrent otitis media 31 HP:0000403

MGI Mouse Phenotypes related to Otitis Media:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCL11 CD40LG CD79A IL10 IL1B IL6
2 homeostasis/metabolism MP:0005376 9.97 MBL2 MUC2 MUC5AC MUC5B TLR2 TLR4
3 digestive/alimentary MP:0005381 9.92 FBXO11 IL10 IL6 MUC2 MUC5AC TLR2
4 immune system MP:0005387 9.8 CCL11 CD40LG CD79A FBXO11 IL10 IL1B
5 neoplasm MP:0002006 9.23 TLR4 TNF CD79A IL10 IL1B IL6

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cedax 17 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
2
Halofantrine Approved Phase 4 69756-53-2 37393
3
Montelukast Approved Phase 4,Phase 3 158966-92-8 5281040
4
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
5
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
6
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 53477736 447043 55185
7
Cefdinir Approved Phase 4,Phase 2,Phase 3 91832-40-5 6915944
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 437-38-7 3345
9
Morphine Approved, Investigational Phase 4 57-27-2 5288826
10
Oseltamivir Approved Phase 4,Phase 3 196618-13-0, 204255-11-8 65028
11
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
13
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
14
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
15 Strawberry Approved, Nutraceutical Phase 4
16
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
17
BCG vaccine Investigational Phase 4
18 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
21 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
22 Clavulanic Acid Phase 4,Phase 3,Phase 2
23 Anti-Asthmatic Agents Phase 4
24 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
25 Hormones Phase 4,Phase 3,Phase 1,Phase 2
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
27 Leukotriene Antagonists Phase 4
28 Respiratory System Agents Phase 4
29 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 1,Phase 2
30 Vaccines Phase 4,Phase 3,Phase 1,Phase 2
31 Analgesics Phase 4,Phase 2,Phase 3
32 Anesthetics Phase 4,Phase 3,Phase 2
33 Anesthetics, General Phase 4,Phase 2,Phase 3
34 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
35 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antitubercular Agents Phase 4,Phase 3,Phase 1
37 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
38 Protective Agents Phase 4,Phase 3
39 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Fluoroquinolones Phase 4,Phase 3,Phase 2,Phase 1
41 Antibiotics, Antitubercular Phase 4,Phase 3
42 Antacids Phase 4
43 Anti-Ulcer Agents Phase 4
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
45 Proton pump inhibitors Phase 4
46 Cephalosporins Phase 4,Phase 2,Phase 3
47 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3
48 Analgesics, Opioid Phase 4,Phase 2,Phase 3
49 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3
50 Narcotics Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 256)

# Name Status NCT ID Phase Drugs
1 Amoxicillin Clavulanate in Treatment of Acute Otitis Media Unknown status NCT00299455 Phase 4 amoxicillin-clavulanate;Placebo
2 The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children Unknown status NCT00393159 Phase 4
3 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
4 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed NCT00189462 Phase 4 Montelukast
5 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children Completed NCT00539149 Phase 4 Amoxycillin;Placebo equivalent to amoxycillin
6 Effect of Prevnar 13 on Ear Infections in Children Completed NCT01199016 Phase 4
7 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4 Lansoprazole;Placebo
8 Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media Completed NCT00195611 Phase 4 Prevenar
9 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media Completed NCT00645112 Phase 4 cefdinir (Omnicef);azithromycin
10 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media Completed NCT00644943 Phase 4 cefdinir (Omnicef);amoxicillin
11 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Completed NCT01244126 Phase 4 Intranasal fentanyl;morphine IM;IV morphine
12 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) Completed NCT00419380 Phase 4 dornase alfa (Pulmozyme®)
13 Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age Completed NCT00593502 Phase 4 oseltamivir;placebo
14 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Completed NCT01800747 Phase 4
15 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
16 Hutterite Influenza Prevention Study Completed NCT00877396 Phase 4
17 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
18 Live Versus Inactivated Influenza Vaccine Study in Hutterite Children Completed NCT01653015 Phase 4
19 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Recruiting NCT02935374 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate;Macrolide
20 Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Recruiting NCT02653742 Phase 4 Ketorolac;Fentanyl
21 Pneumococcal Vaccines Early and in Combination Active, not recruiting NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
22 Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Enrolling by invitation NCT01735084 Phase 4
23 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
24 Otiprio Versus Ciprodex Tympanostomy Tube Outcomes Not yet recruiting NCT03347461 Phase 4 Otiprio;Ciprodex
25 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
26 A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media Unknown status NCT00270660 Phase 3
27 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
28 Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study Unknown status NCT02151916 Phase 3
29 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
30 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children Completed NCT01044030 Phase 3 Xylitol syrup;Placebo
31 Improving Otitis Media Care With Clinical Decision Support Completed NCT00581711 Phase 3
32 Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed NCT02858388 Phase 3
33 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3 OTO-201 (ciprofloxacin)
34 Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children Completed NCT00781521 Phase 3 ofloxacin otic solution 0.3%
35 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3 Moxidex otic solution;Ofloxacin otic solution
36 Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children Completed NCT02541760 Phase 3 Monteleukast;Mometasone
37 Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media Completed NCT00638534 Phase 3 Telithromycin (HMR3647)
38 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3 AR01;Glycerin ear drops
39 Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes Completed NCT00378417 Phase 3
40 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
41 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 Completed NCT02436304 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
42 Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora Completed NCT01027494 Phase 3 Ciprofloxacin 0.3% and dexamethasone 0.1% otic suspension
43 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
44 Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children Completed NCT03116737 Phase 3 Benzocaine Otic Solution;Placebo
45 Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry Completed NCT01244581 Phase 3 Amoxicillin-clavulanate;Placebo
46 Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media Completed NCT00645203 Phase 2, Phase 3 cefdinir
47 Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media Completed NCT00051753 Phase 3 levofloxacin; amoxicillin/clavulanate
48 Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media Completed NCT02630992 Phase 3 Amoxicillin-Clavulanate potassium
49 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01404611 Phase 3 DF289;DF277;DF289 plus DF277
50 Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media Completed NCT00360100 Phase 3 Zmax

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: otitis media

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

# Genetic test Affiliating Genes
1 Otitis Media 28

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

38
Tonsil, Testes, Bone, Lung, Brain, Colon, Neutrophil

Publications for Otitis Media

Articles related to Otitis Media:

(show top 50) (show all 1625)
# Title Authors Year
1
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
2
Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media. ( 29073815 )
2018
3
No evidence of cholesteatoma in untreated otitis media with effusion in children with primary ciliary dyskinesia. ( 29447810 )
2018
4
Response to comment: Eustachian tube diameter: Is it associated with chronic otitis media development? ( 29426733 )
2018
5
The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1I^, IL-1RA Is Favorably Associated With Chronic Otitis Media. ( 29433161 )
2018
6
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
7
Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. ( 29395516 )
2018
8
Clinical role of vitamin D in prognosis of otitis media with effusion. ( 29447793 )
2018
9
Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model. ( 29449589 )
2018
10
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
11
Anatomical anomalies of the Eustachian tube and chronic otitis media. ( 29395282 )
2018
12
Effects of salso-bromo-iodine thermal water in children suffering from otitis media with effusion: a randomized controlled pilot study. ( 29446785 )
2018
13
Air Pollution and Otitis Media in Children: A Systematic Review of Literature. ( 29401661 )
2018
14
Tympanostomy tubes for serous otitis media and risk of recurrences. ( 29447881 )
2018
15
Factors affecting the outcome of adenoidectomy in children treated for chronic otitis media with effusion. ( 29426724 )
2018
16
Neurological Complications of Acute and Chronic Otitis Media. ( 29445883 )
2018
17
Optimal control of asthma improved eosinophilic otitis media. ( 29423372 )
2018
18
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
19
Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control. ( 29415741 )
2018
20
Risk of childhood otitis media with focus on potentially modifiable factors: A Danish follow-up cohort study. ( 29447878 )
2018
21
Pneumococcal phenotype and interaction with nontypeable<i>Haemophilus influenzae</i>as determinants of otitis media progression. ( 29378791 )
2018
22
Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. ( 29322750 )
2018
23
Meningitis as a consequence of otitis media in a child referred from the newborn hearing screening programme: A missed opportunity. ( 29427298 )
2018
24
International consensus (ICON) on management of otitis media with effusion in children. ( 29398506 )
2018
25
Cochlear Implantation in Chronic Otitis Media With Cholesteatoma and Open Cavities: Long-term Surgical Outcomes. ( 29227448 )
2018
26
Cochlear Fistula in Chronic Otitis Media without Cholesteatoma. ( 28704899 )
2017
27
Indicators for continuous quality improvement for otitis media in primary health care for Aboriginal and Torres Strait Islander children. ( 28088980 )
2017
28
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
29
Antibiotic therapy for children with acute otitis media. ( 28904032 )
2017
30
The Predictive Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio for the Effusion Viscosity in Otitis Media With Chronic Effusion. ( 28468206 )
2017
31
The variation in quality and content of patient-focused health information on the Internet for otitis media. ( 28913967 )
2017
32
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. ( 28239580 )
2017
33
Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion. ( 28594978 )
2017
34
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
35
Most cases of otitis media should not be treated with antibiotics, says NICE. ( 28935675 )
2017
36
The human otitis media with effusion: a numerical-based study. ( 28460599 )
2017
37
Intranasal Steroid Use for Otitis Media with Effusion: Ongoing Opportunities for Quality Improvement. ( 28535109 )
2017
38
Polymorphisms of Mannose-binding Lectin and Toll-like Receptors 2, 3, 4, 7 and 8 and the Risk of Respiratory Infections and Acute Otitis Media in Children. ( 28403045 )
2017
39
Healthcare-seeking behaviour of primary caregivers for acute otitis media in children aged 6A months to <30A months in Panama: results of a cross-sectional survey. ( 28056896 )
2017
40
Gradenigo Syndrome and Cavitary Lung Lesions in a 5-Year-Old With Recurrent Otitis Media. ( 28903516 )
2017
41
Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. ( 28487811 )
2017
42
Microbiology of otitis media in Indigenous Australian children: review. ( 28088924 )
2017
43
Determinants of chronic otitis media with effusion in preschool children: a case-control study. ( 28056905 )
2017
44
Can Serum Neutrophil-to-Lymphocyte Ratio Be a Predictive Biomarker to Help Differentiate Active Chronic Otitis Media From Inactive Chronic Otitis Media? ( 28468213 )
2017
45
Brainstem auditory evoked responses in 37 dogs with otitis media before and after topical therapy. ( 28718886 )
2017
46
A Rare Complication of Chronic Otitis Media: Cerebellar Abscess. ( 29392072 )
2017
47
Surgical Success of Tympanoplasty Using Composite Tragal Cartilage in Chronic Otitis Media. ( 28938314 )
2017
48
Comparative Study of Outcome of Endoscopic Myringoplasty in Active and Inactive Mucosal Chronic Otitis Media Patients. ( 28929062 )
2017
49
Iatrogenic trichloroacetic acid injury causing necrotizing otitis media and deafness. ( 28483224 )
2017
50
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017

Variations for Otitis Media

Expression for Otitis Media

LifeMap Discovery
Genes differentially expressed in tissues of Otitis Media patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PNLIPRP3 pancreatic lipase-related protein 3 Blood - 6.47 0.003
2 FAM20A family with sequence similarity 20, member A Blood + 3.09 0.015
Search GEO for disease gene expression data for Otitis Media.

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL11 CD40LG CD79A CXCL8 IGHE IL10
2
Show member pathways
13.47 CCL11 CD40LG CXCL8 IL10 IL1B IL6
3
Show member pathways
13.41 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
4
Show member pathways
13.32 CCL11 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.04 CXCL8 IL1B IL6 MUC2 MUC5AC MUC5B
6
Show member pathways
12.93 CCL11 CD40LG CXCL8 IL10 IL1B IL6
7
Show member pathways
12.86 CXCL8 IL1B IL6 TLR2 TLR4 TNF
8
Show member pathways
12.77 CD40LG IL1B IL6 TLR2 TLR4 TNF
9
Show member pathways
12.67 IL10 IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.66 CD40LG CD79A IGHE IL10 TNF
11
Show member pathways
12.64 CD40LG IL1B TLR2 TLR4 TNF
12 12.64 CD40LG CD79A IL10 IL1B TLR2 TNF
13
Show member pathways
12.62 CXCL8 IL6 TLR2 TLR4 TNF
14
Show member pathways
12.61 CXCL8 IL10 IL1B IL6 TLR2 TLR4
15
Show member pathways
12.5 CD40LG IL10 IL1B IL6 TNF
16
Show member pathways
12.35 CXCL8 IL1B IL6 TLR4 TNF
17
Show member pathways
12.35 CD40LG IL10 IL1B TLR2 TLR4 TNF
18
Show member pathways
12.34 CXCL8 IL6 TLR2 TLR4 TNF
19 12.32 IL10 IL1B IL6 TLR2 TLR4 TNF
20 12.25 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.24 CXCL8 IL10 IL1B IL6 TNF
22 12.23 IL6 TLR2 TLR4 TNF
23
Show member pathways
12.22 CCL11 CXCL8 IL1B IL6 TLR2 TLR4
24
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 MUC5AC MUC5B
25 12.1 CXCL8 IL1B IL6 TLR4 TNF
26 12.06 CD79A IL10 IL6 TNF
27
Show member pathways
12.02 IL10 IL1B IL6 TLR2 TLR4 TNF
28 11.99 CD40LG CXCL8 IL1B TLR4 TNF
29 11.98 CXCL8 IL1B IL6 TNF
30
Show member pathways
11.94 IL1B IL6 TLR2 TLR4
31 11.93 CXCL8 IL1B IL6 TLR2 TLR4 TNF
32 11.91 CXCL8 IL1B IL6 TLR4
33 11.83 IL10 IL1B IL6 TNF
34 11.8 IL10 IL1B TNF
35 11.79 CXCL8 IL10 IL1B IL6 TLR4 TNF
36
Show member pathways
11.77 CD40LG CXCL8 TNF
37
Show member pathways
11.76 CD40LG CXCL8 IL1B IL6 TNF
38 11.76 CCL11 CXCL8 IGHE IL10 IL1B IL6
39 11.75 CCL11 CD40LG IGHE IL10
40 11.7 CD40LG IL10 IL6 TLR2 TLR4 TNF
41 11.64 CCL11 CXCL8 IL1B IL6 MUC5B TNF
42 11.62 IL1B TLR2 TLR4 TNF
43 11.62 CXCL8 IL10 IL1B IL6 TNF
44 11.54 CXCL8 IL1B IL6 TLR2 TLR4 TNF
45 11.54 CXCL8 IL10 IL1B IL6 MUC2 TLR2
46 11.53 IL1B IL6 TNF
47 11.46 IL10 IL1B IL6 TNF
48 11.42 IL10 IL1B IL6 TLR4 TNF
49 11.38 IL1B IL6 TNF
50 11.38 IL10 IL1B IL6 TNF

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 A2ML1 CCL11 CD40LG CXCL8 IGHE IL10
2 external side of plasma membrane GO:0009897 9.55 CD40LG CD79A IGHE TLR4 TNF
3 extracellular space GO:0005615 9.4 A2ML1 CCL11 CD40LG CXCL8 IL10 IL1B

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 IL10 IL1B TLR2 TLR4
2 defense response to bacterium GO:0042742 9.95 IGHE IL10 MBL2 RNASE3 TLR4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL10 IL6 TLR4 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.88 IL10 IL1B IL6 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.87 IL6 RNASE3 TLR4
6 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TNF
7 B cell differentiation GO:0030183 9.86 CD40LG CD79A IL10
8 neutrophil chemotaxis GO:0030593 9.86 CCL11 CXCL8 IL1B
9 response to glucocorticoid GO:0051384 9.85 IL10 IL6 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.85 IL6 MBL2 RNASE3 TLR2 TNF
11 positive regulation of T cell proliferation GO:0042102 9.84 CD40LG IL1B IL6
12 O-glycan processing GO:0016266 9.83 MUC2 MUC5AC MUC5B
13 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IL1B TLR4 TNF
15 B cell proliferation GO:0042100 9.77 CD40LG CD79A IL10
16 positive regulation of phagocytosis GO:0050766 9.77 IL1B MBL2 TNF
17 negative regulation of interleukin-6 production GO:0032715 9.75 IL10 TLR4 TNF
18 positive regulation of interleukin-12 production GO:0032735 9.74 CD40LG TLR2 TLR4
19 positive regulation of interleukin-10 production GO:0032733 9.73 CD40LG TLR2 TLR4
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
21 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B IL6 TLR2 TLR4 TNF
22 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 MBL2 TNF
23 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10 TLR2
24 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TLR4 TNF
25 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
26 regulation of cytokine secretion GO:0050707 9.7 TLR2 TLR4
27 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
29 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
30 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
32 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
33 positive regulation of NF-kappaB import into nucleus GO:0042346 9.67 IL1B TLR2 TLR4 TNF
34 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
35 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 TLR4
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
37 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
38 regulation of immunoglobulin secretion GO:0051023 9.63 CD40LG TNF
39 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
40 positive regulation of chemokine production GO:0032722 9.62 IL6 TLR2 TLR4 TNF
41 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
43 inflammatory response GO:0006954 9.61 CCL11 CD40LG CXCL8 IL10 IL1B IL6
44 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6 TLR2 TLR4 TNF
45 immune response GO:0006955 9.32 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
46 negative regulation of cell proliferation GO:0008285 10.08 CXCL8 IL10 IL1B IL6 TLR2
47 positive regulation of gene expression GO:0010628 10.04 IL1B IL6 TLR2 TLR4 TNF
48 regulation of receptor activity GO:0010469 10.04 CCL11 CD40LG CXCL8 IL10 IL1B IL6

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CD40LG CXCL8 IL10 IL1B IL6
2 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
3 lipopolysaccharide binding GO:0001530 9.13 RNASE3 TLR2 TLR4

Sources for Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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