MCID: OTT002
MIFTS: 60

Otitis Media malady

Ear diseases category

Summaries for Otitis Media

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Wikipedia:63 Otitis media (Latin for \"inflammation of the middle ear\") is the medical term for middle ear... more...

MalaCards: Otitis Media, also known as ear infection &/or otitis media nos, is related to suppurative otitis media and cholesteatoma. An important gene associated with Otitis Media is OMS (otitis media, susceptibility to), and among its related pathways are Immune System and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds dexamethasone and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A otitis which involves inflammation of the middle ear.

CDC:3 Español: Infecciones del oído

Aliases & Classifications for Otitis Media

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 9diseasecard, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

otitis media 8 46 10 44
ear infection &/or otitis media nos 8
otitis media, susceptibility to 9
unspecified otitis media 8
infectious otitis media 60
otitis media nos 8


External Ids:

Disease Ontology8 DOID:10754
ICD9CM27 382.9
MeSH34 D010033
NCIt39 C34885

Related Diseases for Otitis Media

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Otitis Media via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1suppurative otitis media32.1CA13
2cholesteatoma31.4DEFB1
3pneumonia31.2HSF4, LACTB, CD79A, DEFB1, MBL2, TLR2
4influenza31.1CCL11, MBL2, LTF, CD79A, LACTB
5meningitis31.0LACTB, CD79A, MBL2, TLR2
6chronic purulent otitis media31.0HSF4, NR2F6
7tonsillitis30.8DEFB1, CD79A
8rhinitis30.7CCL11, IGHE, CD79A, RNASE3
9tuberculosis30.7LACTB, CD79A, MBL2, TLR2
10allergic rhinitis30.6CCL11, IGHE, RNASE3
11asthma30.6IGHE, RNASE3
12conjunctivitis30.3IGHE, CD79A, RNASE3
13sarcoidosis30.3CD14, DEFB1, CCL11
14vasculitis30.3MBL2, LTF, CD14, CD79A
15diarrhea30.3LTF, CD79A
16osteomyelitis30.3LACTB
17obesity30.3TLR2, CCL11
18inflammatory bowel disease30.1CCL11, TLR2, DEFB1, LTF, MUC5AC, CD14
19bronchiolitis30.1CCL11, IGHE, RNASE3
20peritonitis30.1LACTB, CD14, TLR2
21keratoconjunctivitis30.1CCL11, RNASE3
22dermatitis30.1CCL11, IGHE, CD79A
23arthritis30.1TLR2, LTF, LACTB
24churg-strauss syndrome30.1RNASE3, LTF
25chorioamnionitis30.1LTF, TLR2
26turner syndrome30.1SHOX
27nasopharyngitis10.7
28adenoiditis10.7
29otitis externa10.7
30non-suppurative otitis media10.7
31labyrinthitis10.7
32lateral sinus thrombosis10.6
33facial paralysis10.6
34acute serous otitis media10.6
35chronic adhesive otitis media10.6
36cleft palate10.6
37middle ear disease10.6
38chronic tubotympanic suppurative otitis media10.5
39tympanosclerosis10.5
40sensorineural hearing loss10.5
41purulent acute otitis media10.5
42discharging ear10.4
43middle ear cholesteatoma10.4
44chronic tympanitis10.4
45serous glue ear10.4
46scarlet fever10.4
47chronic atticoantral disease10.4
48wegener's granulomatosis10.4
49pharyngitis10.4
50streptococcal meningitis10.4

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Clinical Features for Otitis Media

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Drugs & Therapeutics for Otitis Media

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Otitis Media

Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Search CenterWatch for Otitis Media

Genetic Tests for Otitis Media

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Anatomical Context for Otitis Media

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Sources:
32MalaCards
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MalaCards organs/tissues related to Otitis Media:

32
Bone, Tonsil, Brain, Testes, Colon, Endothelial, T cells, Temporal lobe, Myeloid, Skin, Lung, Pituitary

Animal Models for Otitis Media or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Otitis Media:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6MBL2, MED1, FBXO11, IGHE, LTF, MUC5AC
2MP:000538710.5SERPINC1, CCL11, TLR2, MBL2, FBXO11, DEFB1
3MP:000539710.3CCL11, TLR2, MBL2, MED1, FBXO11, IGHE

Publications for Otitis Media

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Sources:
50PubMed
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Articles related to Otitis Media:

(show top 50)    (show all 1305)
idTitleAuthorsYear
1
Trends in otitis media-related health care use in the United States, 2001-2011. (24276262)
2014
2
Evolution of acute otitis media. (23599114)
2013
3
Oral antibiotics confer small benefits and small harms in low-risk children with acute otitis media. (23792941)
2013
4
Expression of toll-like receptors in chronic otitis media and cholesteatoma. (23380629)
2013
5
Molecular mechanisms of moraxella catarrhalis-induced otitis media. (23934577)
2013
6
Refractory otitis media: An unusual presentation of childhood granulomatosis with polyangiitis. (23359478)
2013
7
Complications and treatment of chronic otitis media. (23524716)
2013
8
Seasonality of acute otitis media and the role of respiratory viral activity in children. (23249910)
2013
9
Otitis media with effusion in children with cleft lip and palate: a narrative review. (23931986)
2013
10
Detection of the petrosquamosal sinus in chronic otitis media using high-resolution CT. (23764962)
2013
11
The diagnosis and management of acute otitis media. (23439909)
2013
12
Gastroesophageal reflux disease in children with chronic otitis media with effusion. (23524698)
2013
13
Complications of otitis media. (22338586)
2012
14
A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings. (22804826)
2012
15
Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion. (22382400)
2012
16
Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media. (22414497)
2012
17
Inflammation in the middle ear of children with recurrent or chronic otitis media is associated with bacterial load. (22668804)
2012
18
Role of nasopharyngeal reflux in the etiology of otitis media with effusion. (22420439)
2011
19
Structural tympanic membrane changes in secretory otitis media and cholesteatoma. (21765386)
2011
20
Sarcoidosis of the middle ear and chronic suppurative otitis media: coexisting conditions? (21307811)
2011
21
Otogenic cerebral abscess: an unusual complication of otitis media. (22109925)
2011
22
Bacterial biofilm in chronic suppurative otitis media. (20416478)
2010
23
Chronic suppurative otitis media in cleft palate: microorganism etiology and susceptibilities. (19929097)
2009
24
Eya4-deficient mice are a model for heritable otitis media. (18219393)
2008
25
Primary temporal bone secretory meningioma presenting as chronic otitis media. (18172659)
2008
26
Complications of chronic suppurative otitis media and their management. (17277619)
2007
27
Chronic suppurative otitis media: a review. (16198004)
2006
28
Chronic suppurative otitis media with intracranial complication. (22266447)
2006
29
Successful treatment of eosinophilic otitis media using ramatroban: report of two cases. (16899348)
2006
30
Subdural empyema and cerebellar abscess due to chronic otitis media. (15055872)
2004
31
Effectiveness of ototopical antibiotics for chronic suppurative otitis media in Aboriginal children: a community-based, multicentre, double-blind randomised controlled trial. (12914507)
2003
32
Update on topical ototoxicity in chronic suppurative otitis media. (12199183)
2002
33
Cytokines in children with otitis media with effusion. (10993552)
2000
34
Correlation of pure tone audiogram results and hearing benefit of tympanoplasty for chronic suppurative otitis media. (10778893)
2000
35
Lateral sinus thrombosis after untreated otitis media. A clinical problem--again? (10664036)
2000
36
Eosinophils and neutrophils in biopsies from the middle ear of atopic children with otitis media with effusion. (10669113)
1999
37
Facial nerve paralysis in chronic suppurative otitis media: Ankara Numune Hospital experience. (9673730)
1998
38
Bilateral otitis media and mastoiditis caused by a highly resistant strain of Mycobacterium chelonae. (8933554)
1996
39
Preoperative treatment of children with chronic suppurative otitis media. (9145593)
1996
40
Acute otitis media and facial paralysis in children. (8546426)
1996
41
Immunoglobulin-coated bacteria in effusions from secretory and chronic suppurative otitis media. (1928600)
1991
42
The early signs and symptoms of neurotologic complications of chronic suppurative otitis media. (2927213)
1989
43
Quantitative bacterial cultures and beta-lactamase activity in chronic suppurative otitis media. (2565099)
1989
44
Effect on acute suppurative otitis media of procaine penicillin administered once daily compared with the effect of the combination preparation dipenicillin. (12976096)
1952
45
Chronic suppurative otitis media and mastoiditis; management. (15418499)
1950
46
Chronic purulent otitis media. (18919212)
1947
47
A different treatment of chronic purulent otitis media; deep lavage, aeration and application of gold foil membrane bearing ointment of scarlet red. (18896820)
1947
48
Case of Traumatic Destruction of Labyrinth on the Left Side with Hysterical Deafness and Chronic Suppurative Otitis Media on the Right Side. (19986528)
1928
49
SUPPURATIVE OTITIS MEDIA TREATED BY ZINC IONIZATION. (20771490)
1924
50
Chronic Suppurative Otitis Media: Abscess of Lateral Cerebellar Lobe. Recovery after repeated Operations. (19978093)
1914

Genetic Variations for Otitis Media

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Expression for genes affiliated with Otitis Media

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Otitis Media

Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

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53Reactome, 12EMD Millipore
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Pathways related to Otitis Media according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CD79A, CD14, IGHE, DEFB1, MBL2, TLR2
210.5CD14, TLR2, CCL11

Compounds for genes affiliated with Otitis Media

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Otitis Media according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.1RNASE3, MUC5AC, LTF, IGHE, DEFB1, SERPINC1
2polysaccharide4411.1TLR2, LTF, CD14, RNASE3, MUC5AC, MBL2
3retinoic acid44 2412.1MED1, DEFB1, IGHE, LTF, CD14, CD79A
4histamine44 28 2413.0CD14, IGHE, TLR2, CCL11, LTF, RNASE3
5vegf4411.0MBL2, LTF, IGHE, CD14, TLR2, CCL11
6methacholine44 1112.0CCL11, IGHE, LTF, RNASE3, CD14, CD79A
7unicap4411.0RNASE3, CCL11, IGHE, CD14, CD79A
8latex4411.0RNASE3, CD14, LTF, IGHE, TLR2, MBL2
9zymosan4411.0CD14, RNASE3, LTF, MBL2, TLR2
10prednisolone44 28 1113.0CCL11, MBL2, RNASE3, CD79A, CD14, IGHE
11fibrinogen4411.0RNASE3, SERPINC1, TLR2, MBL2, LTF, CD14
12n acetylcysteine4411.0RNASE3, SERPINC1, MUC5AC, LTF, IGHE, CCL11
13polymyxin b4411.0LTF, MBL2, TLR2, CD14, DEFB1
14steroid4411.0CD14, CCL11, MUC5AC, RNASE3, MBL2, MED1
15anti-fungal4411.0LTF, MBL2, TLR2, CD79A, RNASE3
16carbohydrates4411.0CD14, RNASE3, MUC5AC, LTF, IGHE, MBL2
17sodium cromoglycate4411.0IGHE, CCL11, RNASE3, CD79A
18estrogen4411.0SHOX, LTF, CD79A, MBL2, RNASE3
19allergens4411.0RNASE3, CD79A, CD14, CCL11, IGHE
20cyclosporin a44 28 5913.0IGHE, CCL11, CD79A, RNASE3, LTF, CD14
21rantes4410.9CD14, MBL2, RNASE3, TLR2, CCL11
22creatinine4410.9RNASE3, CD79A, MBL2, CD14, IGHE, LTF
23clarithromycin44 1111.9LTF, LACTB, CD79A, CCL11
24mannan4410.9CD79A, MBL2, CD14, TLR2
25penicillin4410.9IGHE, MED1, CD79A, LACTB
26pge24410.9CCL11
27alanine4410.9CD79A, LTF, MED1, IGHE, CCL11, SERPINC1
28heparin44 28 11 2413.9CD79A, CCL11, LTF, CD14, RNASE3
29budesonide44 49 1112.9RNASE3, LTF, IGHE, CCL11
30salbutamol44 49 28 11 2414.9IGHE, CD79A, RNASE3, CCL11
31vitamin d4410.9MBL2, TLR2, CD79A, CD14, IGHE, MED1
32imipenem4410.9MBL2, SERPINC1, LACTB
33mannose4410.9TLR2, CD79A, MBL2, LTF, CD14
34anti-histamine4410.8RNASE3, IGHE, CCL11
35Alpha-D-Mannose1110.8SERPINC1, LTF, MBL2, IGHE
36periodate4410.8MUC5AC, LTF, IGHE
37peptidoglycan44 2811.8CCL11, CD14, TLR2, MBL2
38endotoxin4410.8RNASE3, LTF
39cetirizine44 28 11 2413.8IGHE, RNASE3, CCL11
40pneumococcal4410.8LTF, CD79A, CD14
41neopterin4410.7CD14, CD79A, LTF, MBL2
42ampicillin44 1111.7LTF, LACTB, MED1
43tuberculin4410.7CD79A, CD14, MBL2
44praziquantel44 1111.7IGHE, CD79A, RNASE3
45ketotifen44 1111.6CCL11, IGHE, RNASE3
46gliadin4410.6CD79A, IGHE
47leukotriene b444 59 2412.5TLR2, LTF, RNASE3, CCL11
48ciprofloxacin44 1111.5DEFB1, LTF, LACTB
49silicone4410.4IGHE, SERPINC1, CD79A
50montelukast44 49 28 1113.2RNASE3, CCL11, IGHE

GO Terms for genes affiliated with Otitis Media

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16Gene Ontology
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Cellular components related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SERPINC1, RNASE3, CD14, LTF, IGHE, DEFB1

Biological processes related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.6RNASE3, LTF, DEFB1, MBL2
2negative regulation of growth of symbiont in hostGO:04413010.5MBL2, TLR2
3cellular response to lipoteichoic acidGO:07122310.4CD14, TLR2
4innate immune responseGO:04508710.3TLR2, MBL2, DEFB1, IGHE, CD14

Molecular functions related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:07089110.5CD14, TLR2

Products for genes affiliated with Otitis Media

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Sources for Otitis Media

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet