MCID: OTT002
MIFTS: 54

Otitis Media malady

Summaries for Otitis Media

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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Wikipedia:64 Otitis media (Latin for \"inflammation of the middle ear\") is the medical term for middle ear... more...

MalaCards: Otitis Media, also known as ear infection &/or otitis media nos, is related to suppurative otitis media and sinusitis. An important gene associated with Otitis Media is OMS (otitis media, susceptibility to), and among its related pathways are Immune System and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds dexamethasone and polysaccharide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A otitis which involves inflammation of the middle ear.

CDC:3 Español: Infecciones del oído

Aliases & Classifications for Otitis Media

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

otitis media 8 47 10 45
ear infection &/or otitis media nos 8
otitis media, susceptibility to 9
unspecified otitis media 8
infectious otitis media 61
otitis media nos 8


External Ids:

Disease Ontology8 DOID:10754
ICD9CM27 382.9
MeSH35 D010033
NCIt40 C34885

Related Diseases for Otitis Media

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Otitis Media via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 282)
idRelated DiseaseScoreTop Affiliating Genes
1suppurative otitis media32.1CA13
2sinusitis30.8CCL11, IGHE, CD79A, RNASE3, LACTB
3tonsillitis30.8DEFB1, CD79A
4tuberculosis30.7LACTB, CD79A, MBL2, TLR2
5asthma30.7IGHE, RNASE3
6allergic rhinitis30.6CCL11, IGHE, RNASE3
7atopy30.6CCL11, TLR2, IGHE, CD14, CD79A, RNASE3
8vasculitis30.3MBL2, LTF, CD14, CD79A
9bronchiolitis30.1CCL11, IGHE, RNASE3
10arthritis30.1TLR2, LTF, LACTB
11churg-strauss syndrome30.1RNASE3, LTF
12chorioamnionitis30.1LTF, TLR2
13turner syndrome30.1SHOX
14lateral sinus thrombosis10.7
15chronic adhesive otitis media10.6
16cleft palate10.6
17acute serous otitis media10.6
18tympanosclerosis10.5
19sensorineural hearing loss10.5
20chronic tubotympanic suppurative otitis media10.5
21purulent acute otitis media10.5
22scarlet fever10.4
23mycobacterium abscessus10.4
24streptococcal meningitis10.4
25acute allergic sanguinous otitis media10.4
26acute allergic serous otitis media10.4
27acute sanguinous otitis media10.4
28ankylosis10.3
29subdural empyema10.3
30purulent labyrinthitis10.3
31otosclerosis10.3
32pharyngitis10.3
33chronic rhinitis10.3
34primary ciliary dyskinesia10.3
35common cold10.3
36acute allergic mucoid otitis media10.3
37chronic atticoantral disease10.3
38blue drum syndrome10.3
39temporomandibular ankylosis10.3
40pleomorphic adenoma10.2
41serous glue ear10.2
42petrositis10.2
43nasopharyngitis10.2
44horner's syndrome10.2
45adenoiditis10.2
46adenoma10.2
47cerebrospinal fluid leak10.2
48mycobacterium chelonae10.2
49mycobacterium fortuitum10.2
50tuberculous meningitis10.2

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Clinical Features for Otitis Media

Drugs & Therapeutics for Otitis Media

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Otitis Media

Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Search CenterWatch for Otitis Media

Genetic Tests for Otitis Media

Anatomical Context for Otitis Media

Animal Models for Otitis Media or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Otitis Media:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6MBL2, MED1, FBXO11, IGHE, LTF, MUC5AC
2MP:000538710.5SERPINC1, CCL11, TLR2, MBL2, FBXO11, DEFB1
3MP:000539710.3CCL11, TLR2, MBL2, MED1, FBXO11, IGHE

Publications for Otitis Media

Sources:
51PubMed
See all sources

Articles related to Otitis Media:

(show top 50)    (show all 1306)
idTitleAuthorsYear
1
A novel human enterovirus C (EV-C118) identified in two children hospitalised because of acute otitis media and community-acquired pneumonia in Israel. (23153819)
2013
2
Pneumococcal serotypes causing acute otitis media among children in Barcelona (1992-2011): emergence of the multiresistant clone ST320 of serotype 19A. (23190779)
2013
3
Otitis media: diagnosis and treatment. (24134083)
2013
4
In reference to Triological society best practice, what is the role of tympanostomy tubes in the prevention of recurrent acute otitis media? (24105683)
2013
5
Otorrhea as a sign of medical treatment failure in acute otitis media: two cases with silent mastoiditis complicated with facial palsy. (23602239)
2013
6
Symptoms and otoscopic signs in bilateral and unilateral acute otitis media. (23359578)
2013
7
Middle ear cleft in chronic otitis media: a clinicohistopathological study. (24427703)
2013
8
Otitis media in five cats associated with soft palate abnormalities. (22798343)
2012
9
Quantitative PCR of ear discharge from Indigenous Australian children with acute otitis media with perforation supports a role for Alloiococcus otitidis as a secondary pathogen. (23033913)
2012
10
Facial nerve paralysis due to chronic otitis media: prognosis in restoration of facial function after surgical intervention. (22477011)
2012
11
Probiotics and otitis media in children. (22305688)
2012
12
Clinical efficacy of anti-IgE therapy for eosinophilic otitis media. (22825324)
2012
13
Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children. (23167692)
2012
14
Chronic suppurative otitis media and its association with socio-econonic factors among rural primary school children of bangladesh. (23450091)
2012
15
Effects of hypoxia-inducible factor 1I+ on bone conduction impairment in otitis media with effusion. (22568633)
2012
16
Antibiotics for otitis media with effusion in children. (22972136)
2012
17
Risk factors for failing the hearing screen due to otitis media in Dutch infants. (22207529)
2012
18
FPINa89s clinical inquiries: infectious etiologies of acute otitis media. (23157155)
2012
19
Long-term follow-up of chronic suppurative otitis media in a high-risk children cohort. (21592588)
2011
20
Swab and aspiration specimen collection methods and antibiogram in chronic suppurative otitis media at Jos University Teaching Hospital: Which is superior? (20935423)
2010
21
Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media. (19522649)
2009
22
Review: topical quinolones are better than systemic antibiotics for chronic suppurative otitis media at up to 2 weeks. (17213153)
2006
23
Recurrent otitis media and tonsillitis: common disease predisposition. (16750862)
2006
24
Cervicofacial necrotizing fasciitis: an unusual complication of chronic suppurative otitis media. (16917994)
2006
25
Extracranial complications of chronic suppurative otitis media. (16467754)
2006
26
TH1/TH2 and regulatory cytokines in adults with otitis media with effusion. (16988618)
2006
27
Bacteriological study of paediatric and adult chronic suppurative otitis media. (16761774)
2005
28
Cochlear implantation and management of chronic suppurative otitis media: single stage procedure? (15756568)
2005
29
Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative. (12363420)
2002
30
Effect of 23 valent pneumococcal polysaccharide and Haemophilus influenza conjugated vaccines on the clinical course of otitis media with effusion. (12439177)
2002
31
Properties of recombinant HtrA: an otitis media vaccine candidate antigen from non-typeable Haemophilus influenzae. (11214237)
2000
32
Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media. (10823798)
2000
33
Ceftazidime for outpatient parenteral antibiotic therapy (OPAT) of chronic suppurative otitis media due to Pseudomonas aeruginosa. (10768520)
2000
34
Treatment of otitis media with effusion in children with primary ciliary dyskinesia. (9298603)
1997
35
Use of pre-reduced swabs in bacteriology of chronic suppurative otitis media. (8977860)
1996
36
Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. (8605906)
1995
37
Non-cholesteatomatous suppurative otitis media: facial nerve palsy in an immunocompromised patient. (7561501)
1995
38
Presence of dipeptidyl peptidase II, dipeptidyl peptidase IV, and prolyl endopeptidase in effusion from patients with serous otitis media. (1974452)
1990
39
Bacteriology and drug sensitivity of chronic suppurative otitis media at a central hospital in Zimbabwe. (2611874)
1989
40
Subperiosteal mastoid abscesses in chronic suppurative otitis media. (3408111)
1988
41
Chronic suppurative otitis media in children. (397923)
1979
42
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. (1152752)
1975
43
Treatment of chronic suppurative otitis media. (20328551)
1966
44
ETIOLOGY OF CHRONIC SUPPURATIVE OTITIS MEDIA. (14051405)
1963
45
The surgery of the ear in the management of intracranial complications of chronic suppurative otitis media. (13252333)
1955
46
The treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. (18143038)
1949
47
Diagnosis of complications of chronic suppurative otitis media; report of case. (18896447)
1947
48
The treatment of chronic suppurative otitis media. (20294766)
1947
49
ZINC IONIZATION IN THE TREATMENT OF SUPPURATIVE OTITIS MEDIA. (20773202)
1927
50
Chronic Osteomyelitis of the Labyrinth Capsule (Paralabyrinthitis) in Suppurative Otitis Media. (19979399)
1916

Genetic Variations for Otitis Media

Expression for genes affiliated with Otitis Media

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Otitis Media

Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

Sources:
54Reactome, 12EMD Millipore
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Pathways related to Otitis Media according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CD79A, CD14, IGHE, DEFB1, MBL2, TLR2
210.5CD14, TLR2, CCL11

Compounds for genes affiliated with Otitis Media

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Otitis Media according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1114.1CCL11, TLR2, MBL2, DEFB1, IGHE, LTF
2polysaccharide4511.1TLR2, MBL2, IGHE, LTF, MUC5AC, CD14
3retinoic acid45 2412.1CCL11, TLR2, MED1, DEFB1, IGHE, LTF
4histamine45 29 2413.0CCL11, TLR2, IGHE, LTF, MUC5AC, CD14
5vegf4511.0CCL11, TLR2, MBL2, IGHE, LTF, CD14
6methacholine45 1112.0CCL11, IGHE, LTF, CD14, CD79A, RNASE3
7unicap4511.0RNASE3, CD79A, CD14, IGHE, CCL11
8latex4511.0TLR2, MBL2, IGHE, LTF, CD14, RNASE3
9zymosan4511.0TLR2, MBL2, LTF, CD14, RNASE3
10prednisolone45 29 1113.0CCL11, MBL2, IGHE, CD14, CD79A, RNASE3
11fibrinogen4511.0TLR2, MBL2, LTF, CD14, CD79A, RNASE3
12n acetylcysteine4511.0CCL11, IGHE, LTF, MUC5AC, CD79A, RNASE3
13polymyxin b4511.0TLR2, MBL2, DEFB1, LTF, CD14
14steroid4511.0CCL11, MBL2, MED1, SHOX, MUC5AC, CD14
15anti-fungal4511.0TLR2, MBL2, LTF, CD79A, RNASE3
16carbohydrates4511.0MBL2, IGHE, LTF, MUC5AC, CD14, RNASE3
17sodium cromoglycate4511.0CCL11, IGHE, CD79A, RNASE3
18estrogen4511.0MBL2, SHOX, LTF, CD79A, RNASE3
19allergens4511.0CCL11, IGHE, CD14, CD79A, RNASE3
20cyclosporin a45 29 6013.0CCL11, IGHE, LTF, CD14, CD79A, RNASE3
21rantes4510.9CCL11, TLR2, MBL2, CD14, RNASE3
22creatinine4510.9MBL2, IGHE, LTF, CD14, CD79A, RNASE3
23clarithromycin45 1111.9LACTB, CD79A, LTF, CCL11
24mannan4510.9CD79A, CD14, MBL2, TLR2
25penicillin4510.9LACTB, CD79A, IGHE, MED1
26pge24510.9CCL11
27alanine4510.9CCL11, TLR2, MED1, IGHE, LTF, CD14
28heparin45 29 11 2413.9CCL11, LTF, CD14, CD79A, RNASE3
29budesonide45 50 1112.9RNASE3, LTF, IGHE, CCL11
30salbutamol45 50 29 11 2414.9CCL11, IGHE, CD79A, RNASE3
31vitamin d4510.9TLR2, MBL2, MED1, IGHE, CD14, CD79A
32imipenem4510.9SERPINC1, LACTB, MBL2
33mannose4510.9TLR2, MBL2, LTF, CD14, CD79A
34anti-histamine4510.8CCL11, IGHE, RNASE3
35Alpha-D-Mannose1110.8SERPINC1, LTF, IGHE, MBL2
36periodate4510.8IGHE, LTF, MUC5AC
37peptidoglycan45 2911.8CCL11, TLR2, MBL2, CD14
38endotoxin4510.8RNASE3, LTF
39pneumococcal4510.8CD79A, CD14, LTF
40cetirizine45 29 11 2413.8RNASE3, IGHE, CCL11
41neopterin4510.7CD79A, CD14, LTF, MBL2
42ampicillin45 1111.7MED1, LTF, LACTB
43tuberculin4510.7MBL2, CD14, CD79A
44praziquantel45 1111.7RNASE3, CD79A, IGHE
45ketotifen45 1111.6RNASE3, IGHE, CCL11
46gliadin4510.6IGHE, CD79A
47leukotriene b445 60 2412.5RNASE3, LTF, TLR2, CCL11
48ciprofloxacin45 1111.5LACTB, LTF, DEFB1
49silicone4510.4IGHE, CD79A, SERPINC1
50montelukast45 50 29 1113.2RNASE3, IGHE, CCL11

GO Terms for genes affiliated with Otitis Media

Sources:
16Gene Ontology
See all sources

Cellular components related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SERPINC1, RNASE3, CD14, LTF, IGHE, DEFB1

Biological processes related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.6RNASE3, LTF, DEFB1, MBL2
2negative regulation of growth of symbiont in hostGO:04413010.5MBL2, TLR2
3cellular response to lipoteichoic acidGO:07122310.4CD14, TLR2
4innate immune responseGO:04508710.3TLR2, MBL2, DEFB1, IGHE, CD14

Molecular functions related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:07089110.5CD14, TLR2

Products for genes affiliated with Otitis Media

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Sources for Otitis Media

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet