MCID: OTT002
MIFTS: 60

Otitis Media malady

Ear diseases category

Summaries for Otitis Media

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Wikipedia:63 Otitis media (Latin for \"inflammation of the middle ear\") is the medical term for middle ear... more...

MalaCards: Otitis Media, also known as ear infection &/or otitis media nos, is related to suppurative otitis media and cholesteatoma. An important gene associated with Otitis Media is OMS (otitis media, susceptibility to), and among its related pathways are Immune System and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds dexamethasone and polysaccharide have been mentioned in the context of this disorder. Affiliated tissues include bone, tonsil and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:8 A otitis which involves inflammation of the middle ear.

CDC:3 Español: Infecciones del oído

Aliases & Classifications for Otitis Media

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 9diseasecard, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

otitis media 8 46 10 44
ear infection &/or otitis media nos 8
otitis media, susceptibility to 9
unspecified otitis media 8
infectious otitis media 60
otitis media nos 8


External Ids:

Disease Ontology8 DOID:10754
ICD9CM27 382.9
MeSH34 D010033
NCIt39 C34885

Related Diseases for Otitis Media

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Otitis Media via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1suppurative otitis media32.1CA13
2cholesteatoma31.4DEFB1
3pneumonia31.2HSF4, LACTB, CD79A, DEFB1, MBL2, TLR2
4influenza31.1CCL11, MBL2, LTF, CD79A, LACTB
5meningitis31.0LACTB, CD79A, MBL2, TLR2
6chronic purulent otitis media31.0HSF4, NR2F6
7tonsillitis30.8DEFB1, CD79A
8rhinitis30.7CCL11, IGHE, CD79A, RNASE3
9tuberculosis30.7LACTB, CD79A, MBL2, TLR2
10allergic rhinitis30.6CCL11, IGHE, RNASE3
11asthma30.6IGHE, RNASE3
12conjunctivitis30.3IGHE, CD79A, RNASE3
13sarcoidosis30.3CD14, DEFB1, CCL11
14vasculitis30.3MBL2, LTF, CD14, CD79A
15diarrhea30.3LTF, CD79A
16osteomyelitis30.3LACTB
17obesity30.3TLR2, CCL11
18inflammatory bowel disease30.1CCL11, TLR2, DEFB1, LTF, MUC5AC, CD14
19bronchiolitis30.1CCL11, IGHE, RNASE3
20peritonitis30.1LACTB, CD14, TLR2
21keratoconjunctivitis30.1CCL11, RNASE3
22dermatitis30.1CCL11, IGHE, CD79A
23arthritis30.1TLR2, LTF, LACTB
24churg-strauss syndrome30.1RNASE3, LTF
25chorioamnionitis30.1LTF, TLR2
26turner syndrome30.1SHOX
27nasopharyngitis10.7
28adenoiditis10.7
29otitis externa10.7
30non-suppurative otitis media10.7
31labyrinthitis10.7
32lateral sinus thrombosis10.6
33facial paralysis10.6
34acute serous otitis media10.6
35chronic adhesive otitis media10.6
36cleft palate10.6
37middle ear disease10.6
38chronic tubotympanic suppurative otitis media10.5
39tympanosclerosis10.5
40sensorineural hearing loss10.5
41purulent acute otitis media10.5
42discharging ear10.4
43middle ear cholesteatoma10.4
44chronic tympanitis10.4
45serous glue ear10.4
46scarlet fever10.4
47chronic atticoantral disease10.4
48wegener's granulomatosis10.4
49pharyngitis10.4
50streptococcal meningitis10.4

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to otitis media

Clinical Features for Otitis Media

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Drugs & Therapeutics for Otitis Media

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Otitis Media

Drug clinical trials:

Search ClinicalTrials for Otitis Media

Search NIH Clinical Center for Otitis Media

Search CenterWatch for Otitis Media

Genetic Tests for Otitis Media

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Anatomical Context for Otitis Media

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32MalaCards
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MalaCards organs/tissues related to Otitis Media:

32
Bone, Tonsil, Brain, Testes, Colon, Endothelial, T cells, Myeloid, Pituitary, Lung, Skin, Temporal lobe

Animal Models for Otitis Media or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Otitis Media:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6MBL2, MED1, FBXO11, IGHE, LTF, MUC5AC
2MP:000538710.5SERPINC1, CCL11, TLR2, MBL2, FBXO11, DEFB1
3MP:000539710.3CCL11, TLR2, MBL2, MED1, FBXO11, IGHE

Publications for Otitis Media

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50PubMed
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Articles related to Otitis Media:

(show top 50)    (show all 1305)
idTitleAuthorsYear
1
Improvement rate of acute otitis media caused by Haemophilus influenzae at 1 week is significantly associated with time to recovery. (23966504)
2013
2
Microbiology of chronic suppurative otitis media in a tertiary care setup of uttarakhand state, India. (23724403)
2013
3
Extensive dural sinus thrombosis and bilateral lateral rectus palsy as an uncommon complication of chronic suppurative otitis media. (23355565)
2013
4
Chronic otitis media in children: an evidence-based guide for diagnosis and management. (23539681)
2013
5
Acute otitis media in infants younger than three months not vaccinated against Streptococcus pneumoniae. (23601926)
2013
6
Serum vitamin D levels in children with recurrent otitis media. (23543299)
2013
7
Capsular switching as a strategy to increase pneumococcal virulence in experimental otitis media model. (24361902)
2013
8
Effect of intratympanic mitomycin C on the development of cholesteatoma and otitis media in rats. (23406694)
2013
9
Homeopathic medications as clinical alternatives for symptomatic care of acute otitis media and upper respiratory infections in children. (24381823)
2013
10
Otitis Media With Effusion: Experiences of Children With Cleft Palate and Their Parents. (24237229)
2013
11
Intracranial complications of acute otitis media and Gradenigo's syndrome. (23909122)
2013
12
Catalase-negative Staphylococcus lugdunensis strain with a novel point mutation in the catalase gene isolated from a patient with chronic suppurative otitis media. (23345293)
2013
13
Subdural empyema, retropharyngeal and parapharyngeal space abscess: unusual complications of chronic otitis media. (22764550)
2012
14
Viral load and acute otitis media development after human metapneumovirus upper respiratory tract infection. (22411051)
2012
15
Zinc supplements for preventing otitis media. (22513942)
2012
16
Cochlear implant challenges encountered in tuberculous otitis media. (22546663)
2012
17
Otitis media: epidemiology and management. (22338585)
2012
18
Pathological features in the LmnaDhe/+ mutant mouse provide a novel model of human otitis media and laminopathies. (22819531)
2012
19
Participation of mast cells in chronic otitis media. (22038229)
2011
20
Tuberculous otitis media with facial paralysis: a clinical and microbiological diagnosis-a case report. (22570801)
2011
21
MUC5B Is the predominant mucin glycoprotein in chronic otitis media fluid. (20531251)
2010
22
Increased TLR7 expression in the adenoids among children with otitis media with effusion. (19452306)
2010
23
Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. (19796826)
2009
24
Bilateral otitis media with facial paralysis in a Japanese black calf. (19684349)
2009
25
Incidence of otitis media in children with deformational plagiocephaly. (19816267)
2009
26
Morphological evidence of biofilm formation in Greenlanders with chronic suppurative otitis media. (19283404)
2009
27
Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media. (17350198)
2007
28
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
29
Effect of nitric oxide and nitric oxide synthase on sensorineural hearing loss secondary to secretory otitis media]. (16981472)
2006
30
Complications of chronic otitis media and cholesteatoma. (17097444)
2006
31
Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion. (16298784)
2005
32
Management of chronic suppurative otitis media. (14768072)
2004
33
Petrositis and cerebellar abscess complicating chronic otitis media. (14629535)
2003
34
A rare and serious complication of chronic otitis media: lateral sinus thrombosis. (12927292)
2003
35
Facial paralysis secondary to acute otitis media. (11063365)
2000
36
Classification of chronic suppurative otitis media: type III. (8870360)
1996
37
A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. (8733449)
1996
38
Classification of chronic suppurative otitis media: type VI. (8991223)
1996
39
Mannan-binding protein--levels in plasma and upper-airways secretions and frequency of genotypes in children with recurrence of otitis media. (8403525)
1993
40
Extracranial and intracranial complications of suppurative otitis media. Report of 102 cases. (8288994)
1993
41
Epidemiology of chronic suppurative otitis media in Saudi children. (8444552)
1993
42
Antibiotic treatment of acute otitis media]. (1746853)
1991
43
Causes of chronic suppurative otitis media (CSOM) in Australian aboriginal infants and children. (1365242)
1991
44
The role of bacterial adherence in otitis media with effusion. (2206498)
1990
45
Non-suppurative otitis media. (3235847)
1988
46
Anhydrous Furacin ear solution in the treatment of chronic suppurative otitis media with observations on the use of trichloracetic acid in the closure of tympanic membrane perforations. (13070637)
1953
47
A case of acute suppurative otitis media with tardy occurrence of perisinuous abscess and thrombosis of the sigmoid sinus. (21006614)
1945
48
Chronic Suppurative Otitis Media. (20779844)
1936
49
Three Cases of Chronic Suppurative Otitis Media treated by Ionization. (19983929)
1924
50
Mucous Polypus presenting at the Pharyngeal Orifice of the left Eustachian Tube in a Man suffering from Bilateral Chronic Adhesive Otitis Media. (19974636)
1910

Genetic Variations for Otitis Media

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Expression for genes affiliated with Otitis Media

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Otitis Media

Search GEO for disease gene expression data for Otitis Media.

Pathways for genes affiliated with Otitis Media

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53Reactome, 12EMD Millipore
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Pathways related to Otitis Media according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6CD79A, CD14, IGHE, DEFB1, MBL2, TLR2
210.5CD14, TLR2, CCL11

Compounds for genes affiliated with Otitis Media

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Otitis Media according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.1CCL11, TLR2, MBL2, DEFB1, IGHE, LTF
2polysaccharide4411.1TLR2, MBL2, IGHE, LTF, MUC5AC, CD14
3retinoic acid44 2412.1CCL11, TLR2, MED1, DEFB1, IGHE, LTF
4histamine44 28 2413.0CCL11, TLR2, IGHE, LTF, MUC5AC, CD14
5vegf4411.0CCL11, TLR2, MBL2, IGHE, LTF, CD14
6methacholine44 1112.0CCL11, IGHE, LTF, CD14, CD79A, RNASE3
7unicap4411.0RNASE3, CD79A, CD14, IGHE, CCL11
8latex4411.0TLR2, MBL2, IGHE, LTF, CD14, RNASE3
9zymosan4411.0TLR2, MBL2, LTF, CD14, RNASE3
10prednisolone44 28 1113.0CCL11, MBL2, IGHE, CD14, CD79A, RNASE3
11fibrinogen4411.0TLR2, MBL2, LTF, CD14, CD79A, RNASE3
12n acetylcysteine4411.0CCL11, IGHE, LTF, MUC5AC, CD79A, RNASE3
13polymyxin b4411.0TLR2, MBL2, DEFB1, LTF, CD14
14steroid4411.0CCL11, MBL2, MED1, SHOX, MUC5AC, CD14
15anti-fungal4411.0TLR2, MBL2, LTF, CD79A, RNASE3
16carbohydrates4411.0MBL2, IGHE, LTF, MUC5AC, CD14, RNASE3
17sodium cromoglycate4411.0CCL11, IGHE, CD79A, RNASE3
18estrogen4411.0MBL2, SHOX, LTF, CD79A, RNASE3
19allergens4411.0CCL11, IGHE, CD14, CD79A, RNASE3
20cyclosporin a44 28 5913.0CCL11, IGHE, LTF, CD14, CD79A, RNASE3
21rantes4410.9CCL11, TLR2, MBL2, CD14, RNASE3
22creatinine4410.9MBL2, IGHE, LTF, CD14, CD79A, RNASE3
23clarithromycin44 1111.9LACTB, CD79A, LTF, CCL11
24mannan4410.9CD79A, CD14, MBL2, TLR2
25penicillin4410.9LACTB, CD79A, IGHE, MED1
26pge24410.9CCL11
27alanine4410.9CCL11, TLR2, MED1, IGHE, LTF, CD14
28heparin44 28 11 2413.9CCL11, LTF, CD14, CD79A, RNASE3
29budesonide44 49 1112.9RNASE3, LTF, IGHE, CCL11
30salbutamol44 49 28 11 2414.9CCL11, IGHE, CD79A, RNASE3
31vitamin d4410.9TLR2, MBL2, MED1, IGHE, CD14, CD79A
32imipenem4410.9SERPINC1, LACTB, MBL2
33mannose4410.9TLR2, MBL2, LTF, CD14, CD79A
34anti-histamine4410.8CCL11, IGHE, RNASE3
35Alpha-D-Mannose1110.8SERPINC1, LTF, IGHE, MBL2
36periodate4410.8IGHE, LTF, MUC5AC
37peptidoglycan44 2811.8CCL11, TLR2, MBL2, CD14
38endotoxin4410.8RNASE3, LTF
39pneumococcal4410.8CD79A, CD14, LTF
40cetirizine44 28 11 2413.8RNASE3, IGHE, CCL11
41neopterin4410.7CD79A, CD14, LTF, MBL2
42ampicillin44 1111.7MED1, LTF, LACTB
43tuberculin4410.7MBL2, CD14, CD79A
44praziquantel44 1111.7RNASE3, CD79A, IGHE
45ketotifen44 1111.6RNASE3, IGHE, CCL11
46gliadin4410.6IGHE, CD79A
47leukotriene b444 59 2412.5RNASE3, LTF, TLR2, CCL11
48ciprofloxacin44 1111.5LACTB, LTF, DEFB1
49silicone4410.4IGHE, CD79A, SERPINC1
50montelukast44 49 28 1113.2RNASE3, IGHE, CCL11

GO Terms for genes affiliated with Otitis Media

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16Gene Ontology
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Cellular components related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SERPINC1, RNASE3, CD14, LTF, IGHE, DEFB1

Biological processes related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274210.6RNASE3, LTF, DEFB1, MBL2
2negative regulation of growth of symbiont in hostGO:04413010.5MBL2, TLR2
3cellular response to lipoteichoic acidGO:07122310.4CD14, TLR2
4innate immune responseGO:04508710.3TLR2, MBL2, DEFB1, IGHE, CD14

Molecular functions related to Otitis Media according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:07089110.5CD14, TLR2

Products for genes affiliated with Otitis Media

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  • Antibodies
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Sources for Otitis Media

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet