Aliases & Classifications for Otitis Media

Aliases & Descriptions for Otitis Media:

Name: Otitis Media 54 12 29 52 3 42 14 69
Otitis Media, Susceptibility to 13
Infectious Otitis Media 69

Characteristics:

HPO:

32
otitis media:
Inheritance familial predisposition


Classifications:



External Ids:

OMIM 54 166760
Disease Ontology 12 DOID:10754
ICD9CM 35 382.9
MeSH 42 D010033
NCIt 47 C34885
UMLS 69 C0029882

Summaries for Otitis Media

Disease Ontology : 12 A otitis which involves inflammation of the middle ear.

MalaCards based summary : Otitis Media, also known as otitis media, susceptibility to, is related to labyrinthitis and nasopharyngitis, and has symptoms including recurrent otitis media An important gene associated with Otitis Media is OMS (Otitis Media, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cedax and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tonsil, bone and brain, and related phenotypes are immune system and hematopoietic system

CDC : 3 Español: Infección de oído

Wikipedia : 71 Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis... more...

Description from OMIM: 166760

Related Diseases for Otitis Media

Diseases related to Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 520)
id Related Disease Score Top Affiliating Genes
1 labyrinthitis 30.6 CXCL8 IL10 IL1B IL6 TNF
2 nasopharyngitis 30.6 CD79A CXCL8 IL1B IL6 TNF
3 primary ciliary dyskinesia 30.2 IL10 IL6 TNF
4 tuberculosis 30.2 CD40LG IL10 IL1B IL6 TNF
5 aseptic meningitis 29.9 TLR2 TLR4 TNF
6 fasciitis 29.7 CXCL8 MBL2 TLR2 TNF
7 myiasis 29.3 CD40LG CXCL8 IL10 IL6 TLR4 TNF
8 bacterial meningitis 29.3 ALB CD40LG IL6 TNF
9 tracheitis 29.3 CCL11 CD79A CXCL8 RNASE3 TNF
10 suppurative otitis media 12.6
11 acute serous otitis media 12.5
12 non-suppurative otitis media 12.5
13 chronic purulent otitis media 12.5
14 purulent acute otitis media 12.4
15 chronic tubotympanic suppurative otitis media 12.4
16 acute allergic serous otitis media 12.3
17 acute sanguinous otitis media 12.3
18 acute allergic sanguinous otitis media 12.3
19 adhesive otitis media 12.2
20 acute allergic mucoid otitis media 12.0
21 chronic atticoantral disease 11.9
22 blue drum syndrome 11.7
23 mastoiditis 11.5
24 serous glue ear 11.3
25 pharyngitis 11.3
26 adenoid hypertrophy 11.3
27 eustachian tube disease 11.3
28 kabuki syndrome 2 11.1
29 kabuki syndrome 1 11.1
30 ciliary dyskinesia, primary, 30 10.9
31 ciliary dyskinesia, primary, 2 10.9
32 c1q deficiency 10.9
33 purulent labyrinthitis 10.9
34 deafness, progressive, with stapes fixation 10.9
35 focal labyrinthitis 10.9
36 ciliary dyskinesia, primary, 22 10.9
37 actinobacillosis 10.9
38 recombinant 8 syndrome 10.9
39 middle ear cholesterol granuloma 10.9
40 ciliary dyskinesia, primary, 10 10.9
41 cholesteatoma 10.6
42 pneumonia 10.4
43 influenza 10.4
44 haemophilus influenzae 10.4
45 intussusception 10.4 IL1B TNF
46 thrombosis 10.3
47 adenoiditis 10.3
48 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
49 myeloid proliferations related to down syndrome 10.3 CXCL8 TLR2
50 oculomotor nerve paralysis 10.3 CXCL8 IL1B IL6

Comorbidity relations with Otitis Media via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Bronchitis
Cholesteatoma of Middle Ear Chronic Myocardial Ischemia
Deficiency Anemia Heart Disease
Hypertension, Essential Labyrinthitis
Mastoiditis Otitis Externa
Pneumococcal Meningitis

Graphical network of the top 20 diseases related to Otitis Media:



Diseases related to Otitis Media

Symptoms & Phenotypes for Otitis Media

Symptoms by clinical synopsis from OMIM:

166760

Clinical features from OMIM:

166760

Human phenotypes related to Otitis Media:

32
id Description HPO Frequency HPO Source Accession
1 recurrent otitis media 32 HP:0000403

MGI Mouse Phenotypes related to Otitis Media:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.07 IL6 MBL2 MUC5AC MUC5B TLR2 TLR4
2 hematopoietic system MP:0005397 10.06 MBL2 MUC5B TLR2 TLR4 TNF CCL11
3 digestive/alimentary MP:0005381 9.97 ALB FBXO11 IL10 IL6 MUC5AC TLR2
4 liver/biliary system MP:0005370 9.7 ALB CD79A IL10 IL6 TLR2 TLR4
5 neoplasm MP:0002006 9.56 ALB CD79A IL10 IL1B IL6 TLR2
6 renal/urinary system MP:0005367 9.17 ALB CD40LG CD79A IL6 MBL2 TLR2

Drugs & Therapeutics for Otitis Media

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cedax 17 CEFTIBUTEN DIHYDRATE Schering-Plough Approved December 1995

Drugs for Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 231)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
2
Halofantrine Approved Phase 4 69756-53-2 37393
3
Montelukast Approved Phase 4,Phase 3 158966-92-8 5281040
4
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
5
Cefdinir Approved Phase 4,Phase 2,Phase 3 91832-40-5 6915944
6
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 437-38-7 3345
8
Morphine Approved, Investigational Phase 4 57-27-2 5288826
9
Oseltamivir Approved Phase 4,Phase 3 204255-11-8, 196618-13-0 65028
10
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
12
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
13
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
14 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
17 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
18 Clavulanic Acid Phase 4,Phase 3,Phase 2
19 Aluminum phosphate Phase 4,Phase 1,Phase 2
20 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 1,Phase 2
21 Vaccines Phase 4,Phase 3,Phase 1,Phase 2
22 Anti-Asthmatic Agents Phase 4
23 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
24 Hormones Phase 4,Phase 3,Phase 1,Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
26 Leukotriene Antagonists Phase 4
27 Respiratory System Agents Phase 4
28 Analgesics Phase 4,Phase 2,Phase 3
29 Anesthetics Phase 4,Phase 2,Phase 3
30 Anesthetics, General Phase 4,Phase 2,Phase 3
31 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
34 Protective Agents Phase 4,Phase 3
35 Antibiotics, Antitubercular Phase 4,Phase 3
36 Cephalosporins Phase 4,Phase 2,Phase 3
37 Antacids Phase 4
38 Anti-Ulcer Agents Phase 4
39
Dexlansoprazole Phase 4 138530-94-6, 103577-45-3 9578005
40 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
41
Proton pump inhibitors Phase 4
42 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3
43 Analgesics, Opioid Phase 4,Phase 2,Phase 3
44 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3
45 Narcotics Phase 4,Phase 2,Phase 3
46 Antiviral Agents Phase 4,Phase 3
47 Antitubercular Agents Phase 4,Phase 3,Phase 1
48 Adjuvants, Immunologic Phase 4
49 BCG Vaccine Phase 4
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 246)
id Name Status NCT ID Phase
1 Amoxicillin Clavulanate in Treatment of Acute Otitis Media Unknown status NCT00299455 Phase 4
2 The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children Unknown status NCT00393159 Phase 4
3 Pneumococcal Vaccines Early and in Combination Unknown status NCT01174849 Phase 4
4 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4
5 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed NCT00189462 Phase 4
6 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children Completed NCT00539149 Phase 4
7 Effect of Prevnar 13 on Ear Infections in Children Completed NCT01199016 Phase 4
8 Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media Completed NCT00195611 Phase 4
9 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media Completed NCT00645112 Phase 4
10 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media Completed NCT00644943 Phase 4
11 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children Completed NCT01082029 Phase 4
12 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy Completed NCT01244126 Phase 4
13 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®) Completed NCT00419380 Phase 4
14 Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age Completed NCT00593502 Phase 4
15 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4
16 Hutterite Influenza Prevention Study Completed NCT00877396 Phase 4
17 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
18 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children Recruiting NCT02935374 Phase 4
19 Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children Recruiting NCT02653742 Phase 4
20 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) Recruiting NCT01800747 Phase 4
21 Live Versus Inactivated Influenza Vaccine Study in Hutterite Children Active, not recruiting NCT01653015 Phase 4
22 Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Enrolling by invitation NCT01735084 Phase 4
23 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4
24 TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast) Not yet recruiting NCT03096327 Phase 4
25 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
26 A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media Unknown status NCT00270660 Phase 3
27 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
28 Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study Unknown status NCT02151916 Phase 3
29 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
30 Improving Otitis Media Care With Clinical Decision Support Completed NCT00581711 Phase 3
31 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children Completed NCT01044030 Phase 3
32 Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children Completed NCT00781521 Phase 3
33 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3
34 Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Completed NCT02858388 Phase 3
35 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3
36 Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media Completed NCT00638534 Phase 3
37 Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes Completed NCT00378417 Phase 3
38 Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media Completed NCT00051753 Phase 3
39 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3
40 Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children Completed NCT02541760 Phase 3
41 Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora Completed NCT01027494 Phase 3
42 Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media Completed NCT00645203 Phase 2, Phase 3
43 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3
44 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 Completed NCT02436304 Phase 3
45 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3
46 Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry Completed NCT01244581 Phase 3
47 Acute Otitis Media: Adjuvant Therapy to Improve Outcome Completed NCT00000363 Phase 3
48 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01404611 Phase 3
49 Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media Completed NCT00360100 Phase 3
50 Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays Completed NCT00279916 Phase 3

Search NIH Clinical Center for Otitis Media

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: otitis media

Genetic Tests for Otitis Media

Genetic tests related to Otitis Media:

id Genetic test Affiliating Genes
1 Otitis Media 29

Anatomical Context for Otitis Media

MalaCards organs/tissues related to Otitis Media:

39
Tonsil, Bone, Brain, Neutrophil, Testes, T Cells, Colon

Publications for Otitis Media

Articles related to Otitis Media:

(show top 50) (show all 1552)
id Title Authors Year
1
Acute Otitis Media in Children. ( 28084706 )
2017
2
Meteorological factors, air pollutants, and emergency department visits for otitis media: a time series study. ( 28466414 )
2017
3
Antibiotics in Pregnancy Increase Children's Risk of Otitis Media and Ventilation Tubes. ( 28088397 )
2017
4
Comparison of first year of life acute otitis media admissions before and after the 13-valent pneumococcal conjugate vaccine. ( 28483246 )
2017
5
Indicators for continuous quality improvement for otitis media in primary health care for Aboriginal and Torres Strait Islander children. ( 28088980 )
2017
6
Polymorphisms of Mannose-binding Lectin and Toll-like Receptors 2, 3, 4, 7 and 8 and the Risk of Respiratory Infections and Acute Otitis Media in Children. ( 28403045 )
2017
7
Microbiology of otitis media in Indigenous Australian children: review. ( 28088924 )
2017
8
Recurrent acute otitis media detracts from health-related quality of life. ( 28073387 )
2017
9
The Predictive Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio for the Effusion Viscosity in Otitis Media With Chronic Effusion. ( 28468206 )
2017
10
Otitis Media with Effusion: Our National Practice. ( 28535139 )
2017
11
Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis. ( 28468135 )
2017
12
Authors' reply: changes in gustatory function in patients with chronic otitis media before and after tympanoplasty. ( 28477052 )
2017
13
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
14
The human otitis media with effusion: a numerical-based study. ( 28460599 )
2017
15
Iatrogenic trichloroacetic acid injury causing necrotizing otitis media and deafness. ( 28483224 )
2017
16
Clinical practice guidelines for the diagnosis and management of otitis media with effusion (OME) in children in Japan, 2015. ( 28473270 )
2017
17
Determinants of chronic otitis media with effusion in preschool children: a case-control study. ( 28056905 )
2017
18
Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. ( 28487811 )
2017
19
Intranasal Steroid Use for Otitis Media with Effusion: Ongoing Opportunities for Quality Improvement. ( 28535109 )
2017
20
Healthcare-seeking behaviour of primary caregivers for acute otitis media in children aged 6A months to <30A months in Panama: results of a cross-sectional survey. ( 28056896 )
2017
21
Can Serum Neutrophil-to-Lymphocyte Ratio Be a Predictive Biomarker to Help Differentiate Active Chronic Otitis Media From Inactive Chronic Otitis Media? ( 28468213 )
2017
22
Otitis media in children: A proposal for a new nosological classification. ( 28011068 )
2017
23
Tympanostomy Tube Placement vs Medical Management for Recurrent Acute Otitis Media in TRICARE-Insured Children. ( 28535362 )
2017
24
No evidence for impaired humoral immunity to pneumococcal proteins in Australian Aboriginal children with otitis media. ( 28012512 )
2017
25
Infectious complications of pediatric cochlear implants are highly influenced by otitis media. ( 28483256 )
2017
26
Higher Serum 25(OH)D Concentration is Associated with Lower Risk of Chronic Otitis Media with Effusion: A Case-Control Study. ( 28477429 )
2017
27
Otiprio: An FDA-Approved Ciprofloxacin Suspension Gel for Pediatric Otitis Media With Effusion. ( 28479839 )
2017
28
Values Range of Tympanometric Gradient in Otitis Media With Effusion. ( 28468223 )
2017
29
Response to Effectiveness of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media-A Double-Blind Randomized Clinical Trial in Finland. ( 28064237 )
2017
30
Duration of antibiotics for acute otitis media in under 2 year olds. ( 28470812 )
2017
31
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
32
Volumetric Changes in the Bony External Auditory Canal in Unilateral Chronic Otitis Media. ( 27144233 )
2016
33
Suppurative labyrinthitis associated with otitis media: 26 years' experience. ( 26718959 )
2016
34
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
35
General practice antibiotic prescribing for management of otitis media in children. ( 27622222 )
2016
36
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
37
Differentiating Acute Otitis Media and Acute Mastoiditis in Hospitalized Children. ( 27613655 )
2016
38
Evidence and evidence gaps in the treatment of Eustachian tube dysfunction and otitis media. ( 28025605 )
2016
39
Acute Otitis Media - The Long and the Short of It. ( 28002710 )
2016
40
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
41
Sensorineural hearing loss after otitis media with effusion and subacute mastoiditis after viral infections of the upper respiratory tract: A comparative study of conservative and surgical treatment. ( 27657322 )
2016
42
Treatment of otitis media by transtympanic delivery of antibiotics. ( 27629487 )
2016
43
Serotypes not Included in 13-Valent Pneumococcal Vaccine as Causes of Acute Otitis Media with Spontaneous Tympanic Membrane Perforation in a Geographic Area with High Vaccination Coverage. ( 27997514 )
2016
44
Nystagmus in patients with unilateral acute otitis media complicated by serous labyrinthitis. ( 26797398 )
2016
45
Cochlear implantation in deaf patients with eosinophilic otitis media using subtotal petrosectomy and mastoid obliteration. ( 27168402 )
2016
46
Antibiotic Treatment for First Episode of Acute Otitis Media Is Not Associated with Future Recurrences. ( 27632355 )
2016
47
Iatrogenic facial nerve injuries during chronic otitis media surgery: a multicenter retrospective study. ( 27661064 )
2016
48
Evaluation of the Interleukin-1 Receptor Antagonist and Immunoregulatory Interleukin-10 in the Middle Ear in Chronic Otitis Media With Effusion in Children With and Without Atopy. ( 27090281 )
2016
49
Ten Year Study of Acute Otitis Media in Rochester, NY. ( 27182898 )
2016
50
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016

Variations for Otitis Media

Expression for Otitis Media

LifeMap Discovery
Genes differentially expressed in tissues of Otitis Media patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PNLIPRP3 pancreatic lipase-related protein 3 Blood - 6.47 0.003
2 FAM20A family with sequence similarity 20, member A Blood + 3.09 0.015
Search GEO for disease gene expression data for Otitis Media.

Pathways for Otitis Media

Pathways related to Otitis Media according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 CCL11 CD40LG CD79A CXCL8 IGHE IL10
2
Show member pathways
13.47 CCL11 CD40LG CXCL8 IL10 IL1B IL6
3
Show member pathways
13.41 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
4
Show member pathways
13.32 CCL11 CD40LG CXCL8 IL10 IL1B IL6
5
Show member pathways
13.06 CXCL8 IL1B IL6 MUC5AC MUC5B TLR2
6
Show member pathways
12.98 CXCL8 IL10 IL1B IL6 MBL2 TLR2
7
Show member pathways
12.9 CCL11 CD40LG CXCL8 IL10 IL1B IL6
8
Show member pathways
12.86 CXCL8 IL1B IL6 TLR2 TLR4 TNF
9
Show member pathways
12.77 CD40LG IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.67 IL10 IL1B IL6 TLR2 TLR4 TNF
11
Show member pathways
12.66 CD40LG CD79A IGHE IL10 TNF
12
Show member pathways
12.64 CD40LG IL1B TLR2 TLR4 TNF
13 12.61 CD40LG CD79A IL10 IL1B TLR2 TNF
14
Show member pathways
12.49 CD40LG IL10 IL1B IL6 TNF
15
Show member pathways
12.34 ALB IL1B IL6 TNF
16
Show member pathways
12.34 CXCL8 IL6 TLR2 TLR4 TNF
17
Show member pathways
12.34 CXCL8 IL1B IL6 TLR4 TNF
18
Show member pathways
12.32 CD40LG IL10 IL1B TLR2 TLR4 TNF
19 12.3 IL10 IL1B IL6 TLR2 TLR4 TNF
20 12.25 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.24 CXCL8 IL10 IL1B IL6 TNF
22 12.22 IL6 TLR2 TLR4 TNF
23
Show member pathways
12.22 CCL11 CXCL8 IL1B IL6 TLR2 TLR4
24
Show member pathways
12.19 CCL11 CXCL8 IL1B IL6 MUC5AC MUC5B
25 12.1 CXCL8 IL1B IL6 TLR4 TNF
26 12.06 CD79A IL10 IL6 TNF
27
Show member pathways
12.03 IL10 IL1B IL6 TLR2 TLR4 TNF
28
Show member pathways
11.99 IL1B IL6 TLR2 TLR4
29 11.98 CXCL8 IL1B IL6 TNF
30 11.97 CD40LG CXCL8 IL1B TLR4 TNF
31 11.93 CXCL8 IL1B IL6 TLR2 TLR4 TNF
32 11.9 CXCL8 IL1B IL6 TLR4
33 11.84 IL10 IL1B IL6 TNF
34 11.79 IL10 IL1B TNF
35 11.79 CXCL8 IL10 IL1B IL6 TLR4 TNF
36
Show member pathways
11.77 CD40LG CXCL8 TNF
37 11.76 CCL11 CXCL8 IGHE IL10 IL1B IL6
38 11.75 CCL11 CD40LG IGHE IL10
39
Show member pathways
11.74 CD40LG CXCL8 IL1B IL6 TNF
40 11.73 CD40LG IL10 IL6 TLR2 TLR4 TNF
41 11.64 CCL11 CXCL8 IL1B IL6 MUC5B TNF
42 11.62 IL1B TLR2 TLR4 TNF
43 11.62 CXCL8 IL10 IL1B IL6 TNF
44 11.54 CXCL8 IL1B IL6 TLR2 TLR4 TNF
45 11.53 IL1B IL6 TNF
46 11.48 CXCL8 IL10 IL1B IL6 TLR2 TLR4
47 11.46 IL10 IL1B IL6 TNF
48 11.42 IL10 IL1B IL6 TLR4 TNF
49 11.37 IL1B IL6 TNF
50 11.36 IL10 IL1B IL6 TNF

GO Terms for Otitis Media

Cellular components related to Otitis Media according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 A2ML1 ALB CCL11 CD40LG CXCL8 IGHE
2 external side of plasma membrane GO:0009897 9.63 CD40LG CD79A IGHE IL6 TLR4 TNF
3 extracellular space GO:0005615 9.44 A2ML1 ALB CCL11 CD40LG CXCL8 IL10
4 mucus layer GO:0070701 9.26 MUC5AC MUC5B

Biological processes related to Otitis Media according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL11 IL6 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.96 IL10 IL1B IL6 TLR2 TLR4
3 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL10 IL6 TLR4 TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.89 IL10 IL1B IL6 TNF
5 cellular response to interleukin-1 GO:0071347 9.88 CCL11 CXCL8 IL6
6 response to glucocorticoid GO:0051384 9.87 IL10 IL6 TNF
7 response to insulin GO:0032868 9.87 IL10 IL6 TLR2
8 B cell differentiation GO:0030183 9.87 CD40LG CD79A IL10
9 positive regulation of JNK cascade GO:0046330 9.86 IL1B TLR4 TNF
10 neutrophil chemotaxis GO:0030593 9.85 CCL11 CXCL8 IL1B
11 positive regulation of T cell proliferation GO:0042102 9.85 CD40LG IL1B IL6
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 CD40LG IL1B IL6 TLR2 TLR4 TNF
13 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 MBL2 RNASE3 TLR2 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IL1B IL6 TLR4 TNF
16 defense response to bacterium GO:0042742 9.8 IGHE IL10 MBL2 MUC5B RNASE3 TLR4
17 B cell proliferation GO:0042100 9.79 CD40LG CD79A IL10
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TLR4 TNF
19 positive regulation of phagocytosis GO:0050766 9.77 IL1B MBL2 TNF
20 negative regulation of interleukin-6 production GO:0032715 9.76 IL10 TLR4 TNF
21 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR2 TLR4 TNF
22 positive regulation of interleukin-12 production GO:0032735 9.75 CD40LG TLR2 TLR4
23 positive regulation of interleukin-10 production GO:0032733 9.74 CD40LG TLR2 TLR4
24 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 MBL2 TNF
25 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10 TLR2
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR2 TLR4 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
29 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
30 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
32 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL10 TLR4
34 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
36 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
37 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
38 regulation of immunoglobulin secretion GO:0051023 9.63 CD40LG TNF
39 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
40 positive regulation of chemokine production GO:0032722 9.62 IL6 TLR2 TLR4 TNF
41 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
43 inflammatory response GO:0006954 9.61 CCL11 CD40LG CXCL8 IL10 IL1B IL6
44 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6 TLR2 TLR4 TNF
45 immune response GO:0006955 9.32 CCL11 CD40LG CXCL8 IGHE IL10 IL1B
46 negative regulation of cell proliferation GO:0008285 10.07 CXCL8 IL10 IL1B IL6 TLR2
47 positive regulation of gene expression GO:0010628 10.04 IL1B IL6 TLR2 TLR4 TNF

Molecular functions related to Otitis Media according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 CD40LG CXCL8 IL10 IL1B IL6
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Otitis Media

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