Otomycosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Otomycosis

Sources:
⁸Disease Ontology, ⁶³Wikipedia, ³²MalaCards
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Disease Ontology:⁸ A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. it is characterized by inflammation, pruritus, scaling and severe discomfort. the most common fungi are aspergillus niger and candida albicans.

MalaCards: Otomycosis, also known as singapore ear, is related to coccidioidomycosis and chronic fungal otitis externa. An important gene associated with Otomycosis is CALM3 (calmodulin 3 (phosphorylase kinase, delta)), and among its related pathways are Development EPO-induced Jak-STAT pathway and Thromboxane signalling through TP receptor.

Wikipedia:⁶³ Otomycosis (also known as Singapore Ear) is a fungal ear infection, a superficial mycotic infection of... more...

Aliases & Classifications for Otomycosis

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases

Aliases & Descriptions:

otomycosis ⁸ ¹⁰ ⁶⁰

singapore ear ⁸

External Ids:

Disease Ontology⁸ DOID:0050147

Related Diseases for Otomycosis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Otomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	coccidioidomycosis	10.0
2	chronic fungal otitis externa	10.0
3	middle ear disease	10.0
4	otitis externa	10.0
5	pseudoachondroplasia	10.0	CALM1, CALM2, CALM3
6	toxic encephalopathy	10.0	CALM3, CALM2, CALM1
7	malignant hyperthermia	10.0	CALM1, CALM2, CALM3
8	vascular disease	10.0	CALM3, CALM2, CALM1
9	cholera	10.0	CALM3, CALM2, CALM1
10	pertussis	10.0	CALM1, CALM2, CALM3

Graphical network of diseases related to Otomycosis:

Clinical Features for Otomycosis

Drugs & Therapeutics for Otomycosis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Otomycosis

Drug clinical trials:

Search ClinicalTrials for Otomycosis

Search NIH Clinical Center for Otomycosis

Search CenterWatch for Otomycosis

Genetic Tests for Otomycosis

Anatomical Context for Otomycosis

Animal Models for Otomycosis or affiliated genes

Publications for Otomycosis

Sources:
⁵⁰PubMed
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Articles related to Otomycosis:

(show top 50) (show all 117)

id	Title	Authors	Year
1	Prevalence of otomycosis in Khouzestan Province, south-west Iran. (23164073)	Saki N.... Saki S.	2013
2	Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. (23984100)	Philip A.... Albert R.R.	2013
3	Otomycosis in Shanghai: aetiology, clinical features and therapy. (21999222)	Jia X.... Cao W.	2012
4	Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. (21895787)	Szigeti G.... Varga J.	2012
5	Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review. (22430336)	Viswanatha B.... Vijayashree M.S.	2012
6	Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary. (22359155)	Szigeti G.... Varga J.	2012
7	Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. (21041003)	Saunders J.E.... Berryhill W.E.	2011
8	A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). (22529649)	Palmer K.K.... Manjusha R.	2011
9	Otomycosis in central iran: a clinical and mycological study. (22737432)	Barati B.... Omrani M.R.	2011
10	Otomycosis due to Aspergillus spp. in a dog: case report and literature review. (20492628)	Coyner K.	2010
11	Chronic otomycosis due to malassezia spp. (20606976)	Latha R.... Muruganandam N.	2010
12	Aspergillus otomycosis in an immunocompromised patient. (19006061)	Rutt A.L.... Sataloff R.T.	2008
13	Ototopical antifungals and otomycosis: a review. (18279975)	Munguia R.... Daniel S.J.	2008
14	Scedosporium apiospermum otomycosis. (17606042)	Baumgartner B.J.... Backous D.D.	2007
15	In vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole. (17944704)	Kaya A.D.... Kiraz N.	2007
16	Otomycosis: subdermal growth in calcified mass. (16799802)	Hoshino T.... Matsumoto M.	2006
17	Otomycosis: clinical and mycological study of 97 cases. (17315791)	Araiza J.... Bonifaz A.	2006
18	A case of otomycosis caused by Aspergillus sclerotiorum. (15729874)	Harima N.... Kasai T.	2004
19	Treatment outcome of otomycosis in Ilorin, Nigeria. (12081339)	Ologe F.E.... Nwabuisi C.	2002
20	The fungal profile of otomycosis patients in Ilorin, Nigeria. (11806011)	Nwabuisi C.... Ologe F.E.	2001
21	Otomycosis in Nigeria: treatment with mercurochrome. (11766105)	Mgbor N.... Gugnani H.C.	2001
22	Prevalence of otomycosis in malnourished children in Edo State, Nigeria. (9646512)	Enweani I.B.... Igumbor H.	1997-1998
23	Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment. (9008878)	Chander J.... Handa A.	1996
24	Fungitoxic effect of some organic volatile substances against fungi causing otomycosis. (7739663)	Jain S.K.... Agrawal S.C.	1994
25	Otomycosis in SALo Paulo. (1844531)	Zaror L.... Felipe R.G.	1991
26	Etiological agents of otomycosis in Nigeria. (2503721)	Gugnani H.C.... Njoku-Obi A.N.	1989
27	In vitro effectiveness of 13 agents in otomycosis and review of the literature. (3054372)	Stern J.C.... Lucente F.E.	1988
28	A microbiological study of otomycosis in Visakhapatnam. (3429879)	Anwarullah M.... Jayakar P.A.	1987
29	Clotrimazole powder in the treatment of otomycosis. (3694750)	Kwok P.... Hawke M.	1987
30	Fungal isolates in otomycosis. (6892339)	Chin C.S.... Jegathesan M.	1982
31	Otomycosis in Burma, and its treatment. (6447461)	Than K.M.... Min M.	1980
32	Otitis externa--4: Otomycosis. (1048789)	Rose W.R.	1976
33	Studies on experimental otomycosis in dogs. (4783390)	Sinha B.K.... Kumar R.	1973
34	Polypaecilum insolitum (=Scopulariopsis divaricata) isolated from cases of otomycosis. (5065134)	Yamashita K.... Yamashita T.	1972
35	Root-like hyphal structures in aspergillar otomycosis. (4681322)	Civila E.S.... Conti-DA-az I.A.	1972
36	Otomycosis due to Aspergillus niger. (5473595)	Bezjak V.... Arya O.P.	1970
37	Otomycosis: a clinical entity--clinical and experimental study. (6050987)	Sood V.P.... Mohapatra L.N.	1967
38	Otomycosis: an entity, not a myth. (6071123)		1967
39	Otomycosis. (13956921)	ISMAIL H.K.	1962
40	Otomycosis: a neglected disease. (13708423)	GREGSON A.E.... La touche C.J.	1961
41	Otomycosis. (13241530)	FABRICANT N.D.	1955
42	Trichosporon cutaneum isolated from a case of otomycosis. (13301724)	REIERSOL S.	1955
43	The action of trichomycin upon middle ear disease due to yeast and otomycosis. (13211483)	SAMBE B.... Ishikawa K.	1954
44	Etiology of otomycosis; clinical observations. (15433692)	HALEY L.D.	1950
45	Etiology of otomycosis; mycologic flora of the ear. (15433688)	HALEY L.D.	1950
46	Otomycosis. (18905159)	CAMARA J.A.	1948
47	Otomycosis; some remarks concerning its diagnosis and treatment. (20996337)	GILL W.D.	1946
48	Pathogenicity of the aspergilli of otomycosis. (20999058)	SHARP W.B.... JOHN M.B.	1946
49	Management of otomycosis. (21004521)	GILL E.K.	1945
50	Otomycosis in the Tropics. (20759337)	Highet H.C.	1900

Genes related to Otomycosis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Otomycosis:

id	Symbol	Description	Score	Implication
1	CALM3	calmodulin 3 (phosphorylase kinase, delta)	21.96	GeneCards inferred : Disorders (show sections)
2	CALM1	calmodulin 1 (phosphorylase kinase, delta)	17.96	GeneCards inferred : Disorders (show sections)
3	CALM2	calmodulin 2 (phosphorylase kinase, delta)	13.96	GeneCards inferred : Disorders (show sections)
4	OR4F29	olfactory receptor, family 4, subfamily F, member 29	9.96	GeneCards inferred : Disorders (show sections)
5	C2orf61	chromosome 2 open reading frame 61	5.96	GeneCards inferred : Disorders (show sections)

Products for genes related to Otomycosis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	3	3	4
2	LSBio	-	-	5

Genetic Variations for Otomycosis

Expression for genes affiliated with Otomycosis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Otomycosis

Search GEO for disease gene expression data for Otomycosis.

Pathways for genes affiliated with Otomycosis

Sources:
¹²EMD Millipore, ⁵³Reactome, ³⁷NCBI BioSystems Database, ²⁹KEGG, ⁵¹QIAGEN
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Pathways related to Otomycosis according to GeneCards/GeneDecks:

(show top 50) (show all 83)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Development EPO-induced Jak-STAT pathway Hide members Development EPO-induced Jak-STAT pathway¹²	8.9	CALM3, CALM1, CALM2
2	Thromboxane signalling through TP receptor⁵³ Hide members Development Angiotensin signaling via beta-Arrestin¹²	8.9	CALM1, CALM3, CALM2
3	Endochondral Ossification³⁷	8.9	CALM1, CALM3, CALM2
4	Glycogen breakdown (glycogenolysis)⁵³ Hide members Glycogen Metabolism³⁷	8.9	CALM3, CALM1, CALM2
5	Signal transduction Erk Interactions: Inhibition of Erk¹²	8.9	CALM1, CALM3, CALM2
6	Calcium signaling in the CD4+ TCR pathway³⁷ Hide members Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷	8.9	CALM3, CALM1, CALM2
7	Role of Calcineurin-dependent NFAT signaling in lymphocytes³⁷	8.9	CALM1, CALM3, CALM2
8	Pertussis²⁹	8.9	CALM1, CALM3, CALM2
9	nNOS Signaling at Neuronal Synapses⁵¹	8.9	CALM3, CALM1, CALM2
10	Basal cell carcinoma²⁹ Hide members Melanogenesis²⁹	8.9	CALM3, CALM1, CALM2
11	G13 Signaling Pathway³⁷	8.9	CALM3, CALM1, CALM2
12	ErbB1 downstream signaling³⁷	8.9	CALM2, CALM3, CALM1
13	Regulation of Water Balance by Renal Aquaporins⁵³ Hide members Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation¹²	8.9	CALM2, CALM3, CALM1
14	Immune response ICOS pathway in T-helper cell Hide members Immune response ICOS pathway in T-helper cell¹²	8.9	CALM2, CALM3, CALM1
15	Immune response Function of MEF2 in T lymphocytes¹² Hide members Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis¹²	8.9	CALM3, CALM2, CALM1
16	Immune response NFAT in immune response Hide members Immune response NFAT in immune response¹²	8.9	CALM3, CALM2, CALM1
17	Inositol phosphate metabolism²⁹ Hide members Phosphatidylinositol signaling system²⁹	8.9	CALM3, CALM2, CALM1
18	Signal transduction IP3 signaling Hide members Signal transduction IP3 signaling¹²	8.9	CALM3, CALM2, CALM1
19	Signal transduction cAMP signaling Hide members Signal transduction cAMP signaling¹² G Protein Signaling Pathways³⁷	8.9	CALM2, CALM1, CALM3
20	ICos-ICosL Pathway in T-Helper Cell⁵¹ Hide members CD28 Signaling in T-Helper Cell⁵¹ Calcium Mediated T-Cell Apoptosis⁵¹	8.9	CALM2, CALM3, CALM1
21	Development Ligand-independent activation of ESR1 and ESR2 Hide members Transcription CREB pathway¹²	8.9	CALM1, CALM2, CALM3
22	Oocyte meiosis²⁹	8.9	CALM1, CALM2, CALM3
23	Vascular smooth muscle contraction²⁹	8.9	CALM3, CALM2, CALM1
24	Gastric acid secretion²⁹ Hide members Salivary secretion²⁹	8.9	CALM3, CALM2, CALM1
25	MicroRNAs in cardiomyocyte hypertrophy³⁷	8.9	CALM3, CALM2, CALM1
26	Immune response T cell receptor signaling pathway¹²	8.9	CALM3, CALM2, CALM1
27	Amphetamine addiction²⁹ Hide members Long-term potentiation²⁹	8.9	CALM2, CALM3, CALM1
28	Androgen Signaling⁵¹ Hide members CCR5 Pathway in Macrophages⁵¹	8.9	CALM3, CALM2, CALM1
29	Toll Comparative Pathway⁵¹ Hide members iNOS Signaling⁵¹	8.9	CALM2, CALM3, CALM1
30	Immune response IFN gamma signaling pathway Hide members Immune response IFN gamma signaling pathway¹² IFN-gamma pathway³⁷	8.9	CALM1, CALM2, CALM3
31	N-cadherin signaling events³⁷	8.9	CALM1, CALM2, CALM3
32	Nur77 Signaling in T-Cell⁵¹	8.9	CALM3, CALM2, CALM1
33	Cytoskeleton remodeling RalA regulation pathway¹²	8.9	CALM2, CALM1, CALM3
34	Endothelin³⁷	8.9	CALM2, CALM3, CALM1
35	Lissencephaly gene (LIS1) in neuronal migration and development³⁷	8.9	CALM3, CALM2, CALM1
36	Insulin-mediated glucose transport³⁷	8.9	CALM3, CALM2, CALM1
37	Regulation of cytoplasmic and nuclear SMAD2/3 signaling³⁷	8.9	CALM3, CALM2, CALM1
38	Cellular roles of Anthrax toxin³⁷	8.9	CALM3, CALM2, CALM1
39	p38 MAPK signaling pathway³⁷	8.9	CALM3, CALM2, CALM1
40	Synaptic transmission: ion currents¹²	8.9	CALM1, CALM2, CALM3
41	IL2 signaling events mediated by PI3K³⁷	8.9	CALM1, CALM2, CALM3
42	Cytoskeleton remodeling RalB regulation pathway¹²	8.9	CALM2, CALM1, CALM3
43	Translation Translation regulation by Alpha-1 adrenergic receptors Hide members Translation Translation regulation by Alpha-1 adrenergic receptors¹² Development Activation of ERK by Alpha-1 adrenergic receptors¹²	8.9	CALM1, CALM2, CALM3
44	Immune response CD28 signaling¹²	8.9	CALM3, CALM2, CALM1
45	Visual Cycle in Retinal Rods⁵¹	8.9	CALM2, CALM1, CALM3
46	Signaling events mediated by VEGFR1 and VEGFR2³⁷ Hide members VEGFR1 specific signals³⁷	8.9	CALM3, CALM2, CALM1
47	Downstream signaling in naive CD8+ T cells³⁷	8.9	CALM1, CALM2, CALM3
48	Visual signal transduction- Rods³⁷ Hide members Phototransduction²⁹ The phototransduction cascade⁵³ Inactivation, recovery and regulation of the phototransduction cascade⁵³	8.9	CALM2, CALM1, CALM3
49	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling¹²	8.9	CALM1, CALM2, CALM3
50	Olfactory transduction²⁹	8.1	CALM2, OR4F29, CALM3, CALM1