Otomycosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Otomycosis

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Disease Ontology:⁹ A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. it is characterized by inflammation, pruritus, scaling and severe discomfort. the most common fungi are aspergillus niger and candida albicans.

MalaCards based summary: Otomycosis, also known as singapore ear, is related to coccidioidomycosis and chronic fungal otitis externa. An important gene associated with Otomycosis is CALM3 (calmodulin 3 (phosphorylase kinase, delta)), and among its related pathways are Immune response IFN gamma signaling pathway and Glycogen Metabolism.

Wikipedia:⁶⁴ Otomycosis (also known as Singapore Ear) is a fungal ear infection, a superficial mycotic infection of... more...

Aliases & Classifications for Otomycosis

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS
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Otomycosis, Aliases & Descriptions:

Name: Otomycosis ⁹ ¹¹ ⁶¹

Singapore Ear ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases

External Ids:

Disease Ontology⁹ DOID:0050147

Related Diseases for Otomycosis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Otomycosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	coccidioidomycosis	10.1
2	chronic fungal otitis externa	10.1
3	middle ear disease	10.1
4	otitis externa	10.1
5	pseudoachondroplasia	9.7	CALM2, CALM3, CALM1
6	malignant hyperthermia	9.6	CALM1, CALM3, CALM2
7	pertussis	9.6	CALM2, CALM3, CALM1
8	vascular disease	9.6	CALM1, CALM3, CALM2
9	toxic encephalopathy	9.6	CALM1, CALM3, CALM2
10	cholera	9.5	CALM2, CALM3, CALM1

Graphical network of diseases related to Otomycosis:

Symptoms for Otomycosis

Drugs & Therapeutics for Otomycosis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Otomycosis

Search NIH Clinical Center for Otomycosis

Genetic Tests for Otomycosis

Anatomical Context for Otomycosis

Animal Models for Otomycosis or affiliated genes

Publications for Otomycosis

Sources:
⁵¹PubMed
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Articles related to Otomycosis:

(show top 50) (show all 117)

id	Title	Authors	Year
1	Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. (24949016)	Prasad S.C.... Prasad K.C.	2014
2	Otomycosis; clinical features, predisposing factors and treatment implications. (24948980)	Anwar K.... Gohar M.S.	2014
3	Treatment of refractory Aspergillus otomycosis with voriconazole: case series and review. (24909800)	Ho H.C.... Tsai C.C.	2014
4	Efficacy of topical clotrimazole in treatment of otomycosis. (25098061)	Khan F.... Ullah G.	2013
5	Otomycosis in Shanghai: aetiology, clinical features and therapy. (21999222)	Jia X.... Cao W.	2012
6	Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. (21895787)	Szigeti G.... Varga J.	2012
7	Otomycosis due to filamentous fungi. (21499908)	GarcA-a-Agudo L.... RodrA-guez-Iglesias M.	2011
8	Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. (21041003)	Saunders J.E.... Berryhill W.E.	2011
9	Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus. (20409075)	Ghibaudo G.... Peano A.	2010
10	Otomycosis due to Aspergillus spp. in a dog: case report and literature review. (20492628)	Coyner K.	2010
11	Chronic otomycosis due to malassezia spp. (20606976)	Latha R.... Muruganandam N.	2010
12	Otomycosis: a retrospective study. (19649486)	Pontes Z.B.... Guerra F.S.	2009
13	Aspergillus otomycosis in an immunocompromised patient. (19006061)	Rutt A.L.... Sataloff R.T.	2008
14	Ototopical antifungals and otomycosis: a review. (18279975)	Munguia R.... Daniel S.J.	2008
15	Scedosporium apiospermum otomycosis. (17606042)	Baumgartner B.J.... Backous D.D.	2007
16	Suction clearance and 2% topical miconazole versus the same combination with acidic drops in the treatment of otomycosis. (17883017)	Kiakojuri K.... Sepidgar S.A.	2007
17	Chronic bilateral otomycosis caused by Aspergillus niger. (14998406)	Mishra G.S.... Pal M.	2004
18	In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis. (15310330)	Karaarslan A.... Ozcan K.M.	2004
19	Concomitant otomycosis and dermatomycoses: a clinical and microbiological study. (12520352)	Ozcan M.... Karaarslan F.	2003
20	Otomycosis. (12092275)	Pulec J.L.... Deguine C.	2002
21	Treatment outcome of otomycosis in Ilorin, Nigeria. (12081339)	Ologe F.E.... Nwabuisi C.	2002
22	Otomycosis with pus. (12149832)	Deguine C.... Pulec J.L.	2002
23	Randomized prospective comparative study: short-term treatment with ciclopiroxolamine (cream and solution) versus boric acid in the treatment of otomycosis. (12572722)	del Palacio A.... Garau M.	2002
24	In vitro evaluation of sulfadrugs against fungi causing otomycosis. (15061593)	Jain S.K.... Jain P.C.	2002
25	The fungal profile of otomycosis patients in Ilorin, Nigeria. (11806011)	Nwabuisi C.... Ologe F.E.	2001
26	Otomycosis: the detection of fungi in ears by immunofluorescence microscopy. (9222637)	Gurr P.A.... Gurr S.J.	1997
27	Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment. (9008878)	Chander J.... Handa A.	1996
28	Calcium oxalate crystal deposition in necrotizing otomycosis caused by Aspergillus niger. (8415598)	Landry M.M.... Parkins C.W.	1993
29	Antimycotic effect of fixed oils treated with herbal seeds on the growth of fungi causing otomycosis. (22556643)	Jain S.... Malaiya S.	1993
30	A microbiological study of otomycosis in Visakhapatnam. (3429879)	Anwarullah M.... Jayakar P.A.	1987
31	Broad spectrum antifungal agents in otomycosis. (3746101)	Bassiouny A.... Hindawy D.S.	1986
32	Otomycosis: an experimental evaluation of six antimycotic agents. (6461705)	Maher A.... Hendawy D.S.	1982
33	"How I do it"--otology and neurotology. A specific issue and its solution. Merthiolate in treatment of otomycosis. (7242211)	Schneider M.L.	1981
34	Topical 5-fluorocytosine therapy in otomycosis. (4595093)	SchAPnebeck J.... Zakrisson J.E.	1974
35	Studies on experimental otomycosis in dogs. (4783390)	Sinha B.K.... Kumar R.	1973
36	Otomycosis due to Aspergillus niger. (5473595)	Bezjak V.... Arya O.P.	1970
37	Otomycosis: an entity. (4224861)	McGonigle J.J.... Jillson O.F.	1967
38	Otomycosis: a clinical entity--clinical and experimental study. (6050987)	Sood V.P.... Mohapatra L.N.	1967
39	Tropical otomycosis. (6050986)	Geaney G.P.	1967
40	Otomycosis: an entity, not a myth. (6071123)		1967
41	THE MYTH OF OTOMYCOSIS. (14233233)	KINGERY F.A.	1965
42	Otomycosis. (13241530)	FABRICANT N.D.	1955
43	Etiology of otomycosis; bacterial flora of the ear. (15433689)	HALEY L.D.	1950
44	Relation of various fungi to otomycosis. (20265711)	WOLF F.T.	1947
45	Otomycosis; some remarks concerning its diagnosis and treatment. (20996337)	GILL W.D.	1946
46	Pathogenicity of the aspergilli of otomycosis. (20999058)	SHARP W.B.... JOHN M.B.	1946
47	Etiology of otomycosis. (20999806)	SHARP W.B.... ROBISON J.M.	1946
48	Otomycosis. (21025558)	POHLMAN D.A.	1946
49	Management of otomycosis. (21004521)	GILL E.K.	1945
50	Case of Otomycosis. (19985146)	McKenzie D.	1926

Genes related to Otomycosis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Otomycosis:

- Elite gene

id	Symbol	Description	Score	Implication
1	CALM3	calmodulin 3 (phosphorylase kinase, delta)	23.28	GeneCards inferred via : Disorders (show sections)
2	CALM2	calmodulin 2 (phosphorylase kinase, delta)	16.61	GeneCards inferred via : Disorders (show sections)
3	CALM1	calmodulin 1 (phosphorylase kinase, delta)	9.94	GeneCards inferred via : Disorders (show sections)

Products for genes related to Otomycosis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	3	-	2	1
2	Novus Biologicals	3	3	3	-

Variations for Otomycosis

Expression for genes affiliated with Otomycosis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Otomycosis

Search GEO for disease gene expression data for Otomycosis.

Pathways for genes affiliated with Otomycosis

Sources:
⁴⁹PathCards, ⁵⁹Thomson Reuters, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ⁵²QIAGEN, ³⁰KEGG, ¹³EMD Millipore
See all sources

Pathways related to Otomycosis according to GeneCards/GeneDecks:

(show top 50) (show all 102)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Immune response IFN gamma signaling pathway⁵⁹ Show member pathways IFN-gamma pathway³⁷	8.5	CALM1, CALM3, CALM2
2	Glycogen Metabolism³⁷	8.5	CALM1, CALM3, CALM2
3	MicroRNAs in cardiomyocyte hypertrophy³⁷	8.5	CALM1, CALM3, CALM2
4	Diseases associated with visual transduction⁵⁴ Show member pathways Retinoid metabolism and transport⁵⁴ Biosynthesis of A2E, implicated in retinal degradation⁵⁴ The retinoid cycle in cones (daylight vision)⁵⁴ Visual phototransduction⁵⁴ Retinoid cycle disease events⁵⁴	8.5	CALM1, CALM3, CALM2
5	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵⁴ Show member pathways FCERI mediated Ca+2 mobilization⁵⁴ FCERI mediated MAPK activation⁵⁴ B-Cell Receptor Complex⁵²	8.5	CALM1, CALM3, CALM2
6	Signal transduction Erk Interactions Inhibition of Erk⁵⁹	8.5	CALM1, CALM3, CALM2
7	Pertussis³⁰	8.5	CALM1, CALM3, CALM2
8	Striated Muscle Contraction³⁷ Show member pathways Smooth Muscle Contraction⁵⁴ Muscle contraction⁵⁴ Striated Muscle Contraction⁵⁴	8.5	CALM1, CALM3, CALM2
9	Endothelin³⁷	8.5	CALM1, CALM3, CALM2
10	ErbB1 downstream signaling³⁷	8.5	CALM1, CALM3, CALM2
11	Basal cell carcinoma³⁰ Show member pathways Hedgehog signaling pathway³⁰ Melanogenesis³⁰	8.5	CALM1, CALM3, CALM2
12	p38 MAPK Signaling Pathway³⁷ Show member pathways p38 MAPK signaling pathway³⁷	8.5	CALM1, CALM3, CALM2
13	Cellular roles of Anthrax toxin³⁷	8.5	CALM1, CALM3, CALM2
14	Transcription CREB pathway⁵⁹ Show member pathways Development Ligand independent activation of ESR1 and ESR2⁵⁹	8.5	CALM1, CALM3, CALM2
15	Visual Cycle in Retinal Rods⁵²	8.5	CALM2, CALM1, CALM3
16	Glucose metabolism⁵⁴ Show member pathways Glycogen synthesis⁵⁴ Gluconeogenesis⁵⁴ malate-aspartate shuttle³⁷ glycogen biosynthesis II (from UDP-D-Glucose)³⁷ Glycogen breakdown (glycogenolysis)⁵⁴	8.5	CALM2, CALM3, CALM1
17	Translation Translation regulation by Alpha 1 adrenergic receptors⁵⁹ Show member pathways Development Activation of ERK by Alpha 1 adrenergic receptors⁵⁹	8.5	CALM1, CALM2, CALM3
18	Oocyte meiosis³⁰ Show member pathways Progesterone-mediated oocyte maturation³⁰	8.5	CALM2, CALM3, CALM1
19	Amphetamine addiction³⁰ Show member pathways Cocaine addiction³⁰	8.5	CALM2, CALM3, CALM1
20	Response to elevated platelet cytosolic Ca2+⁵⁴ Show member pathways Platelet degranulation⁵⁴ Disinhibition of SNARE formation⁵⁴	8.5	CALM3, CALM2, CALM1
21	Toll Comparative Pathway⁵² Show member pathways Immune response MIF in innate immunity response⁵⁹ iNOS Signaling⁵² TLR-TRIF Pathway⁵² IL-1 Pathway⁵²	8.5	CALM2, CALM3, CALM1
22	G Protein Signaling Pathways³⁷ Show member pathways Signal transduction cAMP signaling⁵⁹	8.5	CALM3, CALM2, CALM1
23	Immune response Function of MEF2 in T lymphocytes⁵⁹ Show member pathways Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis⁵⁹	8.5	CALM2, CALM1, CALM3
24	Regulation of Water Balance by Renal Aquaporins⁵⁴ Show member pathways Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation⁵⁹ Passive Transport by Aquaporins⁵⁴ Glucagon signaling in metabolic regulation⁵⁴ Aquaporin-mediated transport⁵⁴ Transport of Glycerol from Adipocytes to the Liver by Aquaporins⁵⁴	8.5	CALM1, CALM2, CALM3
25	Androgen Signaling⁵² Show member pathways CCR5 Pathway in Macrophages⁵²	8.5	CALM1, CALM2, CALM3
26	Salivary secretion³⁰ Show member pathways Gastric acid secretion³⁰	8.5	CALM2, CALM1, CALM3
27	ICos-ICosL Pathway in T-Helper Cell⁵² Show member pathways CD28 Signaling in T-Helper Cell⁵² Calcium Mediated T-Cell Apoptosis⁵²	8.5	CALM2, CALM1, CALM3
28	Signaling events mediated by VEGFR1 and VEGFR2³⁷ Show member pathways VEGFR1 specific signals³⁷	8.5	CALM2, CALM3, CALM1
29	IL2 signaling events mediated by PI3K³⁷ Show member pathways IL2 signaling events mediated by STAT5³⁷	8.5	CALM1, CALM2, CALM3
30	Downstream signaling in naive CD8+ T cells³⁷ Show member pathways Ras signaling in the CD4+ TCR pathway³⁷	8.5	CALM1, CALM2, CALM3
31	Insulin-mediated glucose transport³⁷	8.5	CALM2, CALM3, CALM1
32	G13 Signaling Pathway³⁷	8.5	CALM1, CALM2, CALM3
33	Cytoskeleton remodeling RalA regulation pathway⁵⁹	8.5	CALM2, CALM3, CALM1
34	N-cadherin signaling events³⁷	8.5	CALM2, CALM3, CALM1
35	Nur77 Signaling in T-Cell⁵²	8.5	CALM2, CALM3, CALM1
36	nNOS Signaling at Neuronal Synapses⁵²	8.5	CALM2, CALM1, CALM3
37	Metabolism of nitric oxide⁵⁴ Show member pathways eNOS activation⁵⁴ NOSTRIN mediated eNOS trafficking⁵⁴ NOSIP mediated eNOS trafficking⁵⁴ eNOS activation and regulation⁵⁴ Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation⁵⁴ tetrahydrobiopterin de novo biosynthesis³⁷	8.5	CALM3, CALM2, CALM1
38	Endochondral Ossification³⁷	8.5	CALM3, CALM2, CALM1
39	The phototransduction cascade⁵⁴ Show member pathways Visual signal transduction- Rods³⁷ Visual signal transduction- Cones³⁷ Activation of the phototransduction cascade⁵⁴ Inactivation, recovery and regulation of the phototransduction cascade⁵⁴ Phototransduction³⁰	8.5	CALM1, CALM2, CALM3
40	Development EPO induced Jak STAT pathway⁵⁹ Show member pathways EPO Receptor Signaling³⁷ EPO signaling pathway³⁷	8.5	CALM2, CALM1, CALM3
41	Calcineurin-regulated NFAT-dependent transcription in lymphocytes³⁷ Show member pathways Calcium signaling in the CD4+ TCR pathway³⁷	8.5	CALM3, CALM2, CALM1
42	Regulation of cytoplasmic and nuclear SMAD2/3 signaling³⁷	8.5	CALM3, CALM2, CALM1
43	Lissencephaly gene (LIS1) in neuronal migration and development³⁷	8.5	CALM3, CALM1, CALM2
44	Inositol phosphate metabolism⁵⁴ Show member pathways Synthesis of IP3 and IP4 in the cytosol⁵⁴ Synthesis of IPs in the ER lumen⁵⁴ Synthesis of IPs in the nucleus⁵⁴ D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis³⁷ inositol pyrophosphates biosynthesis³⁷ D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis³⁷ Synthesis of pyrophosphates in the cytosol⁵⁴ Synthesis of IP2, IP, and Ins in the cytosol⁵⁴	8.5	CALM3, CALM1, CALM2
45	Post NMDA receptor activation events⁵⁴ Show member pathways Activation of CaMK IV⁵⁴ RSK activation⁵⁴ CaMK IV-mediated phosphorylation of CREB⁵⁴ CREB phosphorylation through the activation of CaMKK⁵⁴ Activation of NMDA receptor upon glutamate binding and postsynaptic events⁵⁴ Unblocking of NMDA receptor, glutamate binding and activation⁵⁴ Ras activation uopn Ca2+ infux through NMDA receptor⁵⁴ CREB phosphorylation through the activation of Ras⁵⁴ Long-term potentiation³⁰ CREB phosphorylation through the activation of CaMKII⁵⁴	8.5	CALM3, CALM1, CALM2
46	Cytoskeleton remodeling RalB regulation pathway⁵⁹	8.5	CALM3, CALM1, CALM2
47	Role of Calcineurin-dependent NFAT signaling in lymphocytes³⁷	8.5	CALM3, CALM1, CALM2
48	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling⁵⁹ Show member pathways DARPP-32 events⁵⁴	8.5	CALM3, CALM1, CALM2
49	Synaptic transmission ion currents¹³	8.5	CALM3, CALM1, CALM2
50	Inositol phosphate metabolism⁵⁴ Show member pathways Synthesis of PI⁵⁴ Inositol phosphate metabolism³⁰ D-myo-inositol-5-phosphate metabolism³⁷ superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism³⁷ D-myo-inositol (1,4,5)-trisphosphate degradation³⁷ superpathway of inositol phosphate compounds³⁷ 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)³⁷ D-myo-inositol (1,4,5)-trisphosphate biosynthesis³⁷ myo-inositol biosynthesis³⁷ 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)³⁷ D-myo-inositol (1,3,4)-trisphosphate biosynthesis³⁷ Phosphatidylinositol signaling system³⁰	8.5	CALM3, CALM1, CALM2

Compounds for genes affiliated with Otomycosis

GO Terms for genes affiliated with Otomycosis

Products for genes affiliated with Otomycosis

Antibodies
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Proteins
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Sources for Otomycosis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: OTM001 MIFTS: 22	Otomycosis malady Ear diseases category
3 genes, 10 related diseases, clinical trials Download this MalaCard Expand all tables

Otomycosis malady