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MCID: OTM001
MIFTS: 39

Otomycosis

Categories: Ear diseases
Genes Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Otomycosis

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MalaCards integrated aliases for Otomycosis:

Name: Otomycosis 12 14 69
Singapore Ear 12

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050147
UMLS 69 C0029895
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Summaries for Otomycosis

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Disease Ontology : 12 An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

MalaCards based summary : Otomycosis, also known as singapore ear, is related to otitis externa and chronic fungal otitis externa, and has symptoms including earache An important gene associated with Otomycosis is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Signaling by Rho GTPases. The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder.

Wikipedia : 72 Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is more... more...

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Related Diseases for Otomycosis

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Diseases related to Otomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 otitis externa 30.0 CALM1 CALM2 CALM3
2 chronic fungal otitis externa 11.0
3 acute dacryocystitis 10.1 CALM1 CALM2 CALM3
4 long qt syndrome 15 10.1 CALM1 CALM2 CALM3
5 external ear disease 10.1 CALM1 CALM2 CALM3
6 deafness, autosomal recessive 44 10.1 CALM1 CALM2 CALM3
7 spontaneous ocular nystagmus 10.1 CALM1 CALM2 CALM3
8 sporotrichosis 10.1 CALM1 CALM2 CALM3
9 dystonia 24 10.1 CALM1 CALM2 CALM3
10 triosephosphate isomerase deficiency 10.1 CALM1 CALM2 CALM3
11 leber congenital amaurosis 2 10.1 CALM1 CALM2 CALM3
12 primary systemic mycosis 10.1 CALM1 CALM2 CALM3
13 gestational choriocarcinoma 10.0 CALM1 CALM3
14 cardiomyopathy, dilated, 1a 10.0 CALM1 CALM2 CALM3
15 clear cell acanthoma 10.0 CALM1 CALM2 CALM3
16 cardiomyopathy, dilated, 1p 10.0 CALM1 CALM2 CALM3
17 deafness, autosomal dominant 2a 10.0 CALM1 CALM2 CALM3
18 primary cutaneous amyloidosis 10.0 CALM1 CALM2 CALM3
19 catecholaminergic polymorphic ventricular tachycardia 10.0 CALM1 CALM2 CALM3
20 long qt syndrome 1 9.9 CALM1 CALM2 CALM3
21 blood group, i system 9.9
22 coccidioidomycosis 9.9
23 auditory system disease 9.9
24 middle ear disease 9.9
25 long qt syndrome 9.9 CALM1 CALM2 CALM3
26 exophthalmos 9.8 FLNA RHNO1

Graphical network of the top 20 diseases related to Otomycosis:



Diseases related to Otomycosis
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Symptoms & Phenotypes for Otomycosis

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UMLS symptoms related to Otomycosis:


earache
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Drugs & Therapeutics for Otomycosis

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Drugs for Otomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3 Pharmaceutical Solutions Phase 3
4 Autonomic Agents Phase 3
5 Peripheral Nervous System Agents Phase 3
6 Hormone Antagonists Phase 3,Phase 2
7 Hormones Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
9 Antiemetics Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Antineoplastic Agents, Hormonal Phase 3
12 BB 1101 Phase 3
13 Dexamethasone acetate Phase 3 1177-87-3
14 Gastrointestinal Agents Phase 3
15 glucocorticoids Phase 3
16 HIV Protease Inhibitors Phase 3
17
protease inhibitors Phase 3
18
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
19 Antifungal Agents Phase 2
20 Anti-Infective Agents Phase 2
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
22 Cytochrome P-450 CYP3A Inhibitors Phase 2
23 Cytochrome P-450 Enzyme Inhibitors Phase 2
24 Steroid Synthesis Inhibitors Phase 2
25
Ephedrine Approved 299-42-3 9294
26
Ethanol Approved 64-17-5 702
27
Pseudoephedrine Approved 90-82-4 7028
28 Nasal Decongestants
29 Ophthalmic Solutions
30 Respiratory System Agents
31 Tetrahydrozoline
32 Vasoconstrictor Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
2 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3 FST-201 (dexamethasone 0.1%) Otic Suspension;Vehicle
3 Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis Recruiting NCT03130738 Phase 2 7-Day Miconazole Oil;14-Day Miconazole Oil;14-Day Placebo - Oil Vehicle
4 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients Completed NCT01547221 clotrimazole;3% Boric acid

Search NIH Clinical Center for Otomycosis

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Genetic Tests for Otomycosis

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Anatomical Context for Otomycosis

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Publications for Otomycosis

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Articles related to Otomycosis:

(show top 50) (show all 138)
# Title Authors Year
1
Assessment of Response to Treatment in Patients with Otomycosis. ( 29387663 )
2018
2
A case of bilateral otomycosis associated with Aspergillus flavus and A.A terreus in Taiwan. ( 28501466 )
2017
3
Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium. ( 28042402 )
2017
4
Otomycosis in immunocompetent patients: Clinical and mycological features. Our experience with 40 cases. ( 28834405 )
2017
5
Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment. ( 28549873 )
2017
6
Otomycosis in a Rural Community Attending a Tertiary Care Hospital: Assessment of Risk Factors and Identification of Fungal and Bacterial Agents. ( 28764159 )
2017
7
Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. ( 27127015 )
2016
8
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. ( 27477534 )
2016
9
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( 26600419 )
2016
10
Otomycosis in Adolescent Patients Referred to the Therapeutic Centers in Babol City, Iran. ( 26060563 )
2015
11
Etiologic Agents of Otomycosis in the North-Western Area of Iran. ( 26495108 )
2015
12
Epidemiology, causative agents, and risk factors affecting human otomycosis infections. ( 26422852 )
2015
13
Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis? ( 25621236 )
2015
14
Otomycosis in Iran: A Review. ( 25633436 )
2015
15
Lamisil, a potent alternative antifungal drug for otomycosis. ( 28680976 )
2015
16
Scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: Management of this rare entity. ( 26298623 )
2015
17
Otomycosis in Jos: Predisposing factors and Management. ( 26690089 )
2014
18
Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. ( 24949016 )
2014
19
Treatment of refractory Aspergillus otomycosis with voriconazole: case series and review. ( 24909800 )
2014
20
Otomycosis; clinical features, predisposing factors and treatment implications. ( 24948980 )
2014
21
Prevalence of otomycosis in Khouzestan Province, south-west Iran. ( 23164073 )
2013
22
Efficacy of topical clotrimazole in treatment of otomycosis. ( 25098061 )
2013
23
Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents. ( 23595615 )
2013
24
Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ( 23984100 )
2013
25
Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. ( 21895787 )
2012
26
Otomycosis with Perforated Tympanic Membrane: Self medication with Topical Antifungal Solution versus Medicated Ear Wick. ( 23267306 )
2012
27
Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review. ( 22430336 )
2012
28
Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary. ( 22359155 )
2012
29
Otomycosis in Shanghai: aetiology, clinical features and therapy. ( 21999222 )
2012
30
Otomycosis in central iran: a clinical and mycological study. ( 22737432 )
2011
31
Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. ( 21041003 )
2011
32
A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). ( 22529649 )
2011
33
Otomycosis due to filamentous fungi. ( 21499908 )
2011
34
Prevalence of otomycosis in Ibadan: a review of laboratory reports. ( 22420052 )
2010
35
Otomycosis: Diagnosis and treatment. ( 20347664 )
2010
36
Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus. ( 20409075 )
2010
37
Chronic otomycosis due to malassezia spp. ( 20606976 )
2010
38
Otomycosis due to Aspergillus spp. in a dog: case report and literature review. ( 20492628 )
2010
39
Otomycosis: a retrospective study. ( 19649486 )
2009
40
Aspergillus otomycosis in an immunocompromised patient. ( 19006061 )
2008
41
Ototopical antifungals and otomycosis: a review. ( 18279975 )
2008
42
Otomycosis in western Nigeria. ( 18076598 )
2008
43
Suction clearance and 2% topical miconazole versus the same combination with acidic drops in the treatment of otomycosis. ( 17883017 )
2007
44
Scedosporium apiospermum otomycosis. ( 17606042 )
2007
45
Outer limits. An overview of otomycosis. ( 20014678 )
2007
46
In vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole. ( 17944704 )
2007
47
Otomycosis: clinical and mycological study of 97 cases. ( 17315791 )
2006
48
Otomycosis: subdermal growth in calcified mass. ( 16799802 )
2006
49
Otomycosis: clinical features and treatment implications. ( 17071313 )
2006
50
Topical antibiotic induced otomycosis. ( 15885342 )
2005
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Variations for Otomycosis

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Expression for Otomycosis

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Search GEO for disease gene expression data for Otomycosis.
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Pathways for Otomycosis

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Pathways related to Otomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 62
Show member pathways
 13.19 CALM1 CALM2 CALM3 CD99 FLNA
2
Signaling by Rho GTPases 62
Show member pathways
 12.91 CALM1 CALM2 CALM3 FLNA
3
Actin Nucleation by ARP-WASP Complex 60
Show member pathways
 12.88 CALM1 CALM2 CALM3 FLNA
4
CCR5 Pathway in Macrophages 60
Show member pathways
 12.77 CALM1 CALM2 CALM3 CXCL14
5
Aquaporin-mediated transport 62
Show member pathways
 12.34 CALM1 CALM2 CALM3
6
CLEC7A (Dectin-1) signaling 62
Show member pathways
 12.33 CALM1 CALM2 CALM3
7
Presynaptic function of Kainate receptors 62
Show member pathways
 12.32 CALM1 CALM2 CALM3
8
RhoGDI Pathway 60
Show member pathways
 12.3 CALM1 CALM2 CALM3
9
ICos-ICosL Pathway in T-Helper Cell 60
Show member pathways
 12.29 CALM1 CALM2 CALM3
10
B cell receptor signaling pathway (KEGG) 1
Show member pathways
 12.29 CALM1 CALM2 CALM3
11
Semaphorin interactions 62
Show member pathways
 12.28 CALM1 CALM2 CALM3 FLNA
12
Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways 61
Show member pathways
 12.27 CALM1 CALM2 CALM3
13
Dopamine-DARPP32 Feedback onto cAMP Pathway 60
12.26 CALM1 CALM2 CALM3
14
Oocyte meiosis 36
Show member pathways
 12.25 CALM1 CALM2 CALM3
15
Immune response CCR3 signaling in eosinophils 21
Show member pathways
 12.25 CALM1 CALM2 CALM3
16
Metabolism of fat-soluble vitamins 62
Show member pathways
 12.23 CALM1 CALM2 CALM3
17
Development Ligand-independent activation of ESR1 and ESR2 21
Show member pathways
 12.22 CALM1 CALM2 CALM3
18
B Cell Receptor Signaling Pathway (sino) 63
Show member pathways
 12.22 CALM1 CALM2 CALM3
19
cAMP signaling pathway 36
Show member pathways
 12.2 CALM1 CALM2 CALM3
20
Toll Comparative Pathway 60
Show member pathways
 12.17 CALM1 CALM2 CALM3
21
Platelet homeostasis 62
Show member pathways
 12.16 CALM1 CALM2 CALM3
22
Calcium signaling pathway 36
Show member pathways
 12.16 CALM1 CALM2 CALM3
23
Post NMDA receptor activation events 62
Show member pathways
 12.14 CALM1 CALM2 CALM3
24
Tuberculosis 36
12.13 CALM1 CALM2 CALM3
25
CD28 co-stimulation 62
Show member pathways
 12.11 CALM1 CALM2 CALM3
26
Long-term potentiation 36
Show member pathways
 12.09 CALM1 CALM2 CALM3
27
Salivary secretion 36
Show member pathways
 12.08 CALM1 CALM2 CALM3
28
ADP signalling through P2Y purinoceptor 1 62
Show member pathways
 12.07 CALM1 CALM2 CALM3
29
Cellular senescence (KEGG) 36
12.06 CALM1 CALM2 CALM3
30
Phototransduction 36
Show member pathways
 12.05 CALM1 CALM2 CALM3
31
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 21
Show member pathways
 12.04 CALM1 CALM2 CALM3 CD99 CXCL14
32
Immune response Function of MEF2 in T lymphocytes 21
Show member pathways
 12.03 CALM1 CALM2 CALM3
33
Fluid shear stress and atherosclerosis 36
12 CALM1 CALM2 CALM3
34
Apelin signaling pathway 36
11.99 CALM1 CALM2 CALM3
35
Translation Translation regulation by Alpha-1 adrenergic receptors 21
Show member pathways
 11.93 CALM1 CALM2 CALM3
36
Amphetamine addiction 36
Show member pathways
 11.91 CALM1 CALM2 CALM3
37
Inositol phosphate metabolism (REACTOME) 62
Show member pathways
 11.89 CALM1 CALM2 CALM3
38
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 62
Show member pathways
 11.86 CALM1 CALM2 CALM3
39
Glucagon signaling pathway 36
11.84 CALM1 CALM2 CALM3
40
ErbB1 downstream signaling 1
11.83 CALM1 CALM2 CALM3
41
Development EPO-induced Jak-STAT pathway 21
Show member pathways
 11.81 CALM1 CALM2 CALM3
42
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.78 CALM1 CALM2 CALM3
43
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 21
Show member pathways
 11.77 CALM1 CALM2 CALM3
44
Immune response IFN gamma signaling pathway 21
Show member pathways
 11.71 CALM1 CALM2 CALM3
45
Uptake and actions of bacterial toxins 62
Show member pathways
 11.7 CALM1 CALM2 CALM3
46
Metabolism of nitric oxide 62
Show member pathways
 11.69 CALM1 CALM2 CALM3
47
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.67 CALM1 CALM2 CALM3
48
Pertussis 36
11.67 CALM1 CALM2 CALM3
49
Phase 0 - rapid depolarisation 62
Show member pathways
 11.66 CALM1 CALM2 CALM3
50
Signal transduction_Erk Interactions- Inhibition of Erk 21
11.64 CALM1 CALM2 CALM3
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GO Terms for Otomycosis

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Cellular components related to Otomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.73 CALM1 CALM2 CALM3 FLNA
2 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
3 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
6 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
7 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
8 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Otomycosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
2 positive regulation of cAMP biosynthetic process GO:0030819 9.76 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.75 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.74 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 regulation of cytokinesis GO:0032465 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein autophosphorylation GO:0031954 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein dephosphorylation GO:0035307 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 CALM1 CALM2 CALM3
12 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
13 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
14 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
15 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
16 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
17 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
18 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.33 CALM1 CALM2 CALM3
19 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
20 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.65 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.62 CALM1 CALM2 CALM3 FLNA
3 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
4 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
5 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
6 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
7 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
8 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
9 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3
10 protein binding GO:0005515 10.16 CALM1 CALM2 CALM3 CBS CD99 CXCL14
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Sources for Otomycosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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