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MCID: OTM001
MIFTS: 38

Otomycosis malady

Categories: Skin diseases, Ear diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Otomycosis

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Aliases & Descriptions for Otomycosis:

Name: Otomycosis 12 14 69
Singapore Ear 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050147
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Summaries for Otomycosis

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Disease Ontology : 12 An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

MalaCards based summary : Otomycosis, also known as singapore ear, is related to chronic fungal otitis externa and bleeding disorder, platelet-type, 15, and has symptoms including earache An important gene associated with Otomycosis is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 71 Otomycosis is a fungal ear infection, a superficial mycotic infection of the outer ear canal. It is more... more...

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Related Diseases for Otomycosis

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Diseases related to Otomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 chronic fungal otitis externa 10.8
2 bleeding disorder, platelet-type, 15 10.1 CALM1 CALM2 CALM3
3 microphthalmia with limb anomalies 10.1 CALM1 CALM2 CALM3
4 subclavian steal syndrome 10.1 CALM1 CALM2 CALM3
5 leukemia, acute lymphoblastic 2 10.1 CALM1 CALM2 CALM3
6 short stature with microcephaly and distinctive facies 10.1 CALM1 CALM2 CALM3
7 neuropathy, hereditary sensory and autonomic, type ii 10.1 CALM1 CALM2 CALM3
8 dumping syndrome 10.1 CALM1 CALM2 CALM3
9 arthropathy 10.1 CALM1 CALM2 CALM3
10 chronic dacryoadenitis 10.1 CALM1 CALM2 CALM3
11 retinitis pigmentosa 20 10.1 CALM1 CALM2 CALM3
12 regular astigmatism 10.1 CALM1 CALM2 CALM3
13 familial sick sinus syndrome 10.1 CALM1 CALM2 CALM3
14 lipodystrophy, familial partial, 2 10.1 CALM1 CALM2 CALM3
15 ciliary dyskinesia, primary, 11 10.1 CALM1 CALM2 CALM3
16 deafness, autosomal dominant 2a 10.1 CALM1 CALM2 CALM3
17 encephalomalacia 10.1 CALM1 CALM3
18 congenital hypothyroidism 10.1 CALM1 CALM2 CALM3
19 distal arthrogryposis 10.1 CALM1 CALM2 CALM3
20 partial of retinal vein occlusion 10.1 CALM1 CALM2 CALM3
21 neurofibroma 10.1 CALM1 CALM2 CALM3
22 autosomal dominant nocturnal frontal lobe epilepsy 2 10.0 CALM1 CALM2 CALM3
23 mastoiditis 10.0 CALM1 CALM2 CALM3
24 hypolipoproteinemia 10.0 BRD4 RHNO1
25 atrial fibrillation, familial, 3 10.0 CALM1 CALM2 CALM3
26 hyperthyroxinemia 10.0 CALM1 CALM2 CALM3
27 acute laryngitis 9.9 FLNA RHNO1
28 coccidioidomycosis 9.8
29 middle ear disease 9.8
30 otitis externa 9.8
31 aspiration pneumonia 8.7 BRD4 CALM1 CALM2 CALM3 CBS CD99

Graphical network of the top 20 diseases related to Otomycosis:



Diseases related to Otomycosis
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Symptoms & Phenotypes for Otomycosis

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UMLS symptoms related to Otomycosis:


earache
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Drugs & Therapeutics for Otomycosis

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Drugs for Otomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3 Peripheral Nervous System Agents Phase 3
4 Pharmaceutical Solutions Phase 3
5 Autonomic Agents Phase 3
6 Hormone Antagonists Phase 3,Phase 2
7 Hormones Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
9 Dexamethasone acetate Phase 3 1177-87-3
10 glucocorticoids Phase 3
11
protease inhibitors Phase 3
12 Gastrointestinal Agents Phase 3
13 HIV Protease Inhibitors Phase 3
14 Dexamethasone 21-phosphate Phase 3
15 Antiemetics Phase 3
16 Anti-Inflammatory Agents Phase 3
17 BB 1101 Phase 3
18 Antineoplastic Agents, Hormonal Phase 3
19
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
20 Steroid Synthesis Inhibitors Phase 2
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
22 Cytochrome P-450 CYP3A Inhibitors Phase 2
23 Cytochrome P-450 Enzyme Inhibitors Phase 2
24 Anti-Infective Agents Phase 2
25 Antifungal Agents Phase 2
26
Ethanol Approved 64-17-5 702
27
Ephedrine Approved 299-42-3 9294
28
Pseudoephedrine Approved 90-82-4 7028
29 Nasal Decongestants
30 Tetrahydrozoline
31 Ophthalmic Solutions
32 Vasoconstrictor Agents
33 Respiratory System Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3
2 FST-201 In The Treatment of Acute Fungal Otitis Externa Terminated NCT00945646 Phase 3
3 Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis Recruiting NCT03130738 Phase 2
4 Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients Completed NCT01547221

Search NIH Clinical Center for Otomycosis

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Genetic Tests for Otomycosis

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Anatomical Context for Otomycosis

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MalaCards organs/tissues related to Otomycosis:

39
Skin
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Publications for Otomycosis

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Articles related to Otomycosis:

(show top 50) (show all 132)
id Title Authors Year
1
Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium. ( 28042402 )
2017
2
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( 26600419 )
2016
3
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. ( 27477534 )
2016
4
Large discrepancies in otomycosis treatment in private ear, nose, and throat clinics in Denmark. ( 27127015 )
2016
5
Type of Antifungals: Does it Matter in Empirical Treatment of Otomycosis? ( 25621236 )
2015
6
Scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: Management of this rare entity. ( 26298623 )
2015
7
Epidemiology, causative agents, and risk factors affecting human otomycosis infections. ( 26422852 )
2015
8
Otomycosis in Adolescent Patients Referred to the Therapeutic Centers in Babol City, Iran. ( 26060563 )
2015
9
Etiologic Agents of Otomycosis in the North-Western Area of Iran. ( 26495108 )
2015
10
Otomycosis in Iran: A Review. ( 25633436 )
2015
11
Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. ( 24949016 )
2014
12
Otomycosis in Jos: Predisposing factors and Management. ( 26690089 )
2014
13
Treatment of refractory Aspergillus otomycosis with voriconazole: case series and review. ( 24909800 )
2014
14
Otomycosis; clinical features, predisposing factors and treatment implications. ( 24948980 )
2014
15
Efficacy of topical clotrimazole in treatment of otomycosis. ( 25098061 )
2013
16
Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents. ( 23595615 )
2013
17
Effectiveness of 7.5 percent povidone iodine in comparison to 1 percent clotrimazole with lignocaine in the treatment of otomycosis. ( 23984100 )
2013
18
Prevalence of otomycosis in Khouzestan Province, south-west Iran. ( 23164073 )
2013
19
Molecular identification and antifungal susceptibilities of black Aspergillus isolates from otomycosis cases in Hungary. ( 22359155 )
2012
20
Otomycosis in Shanghai: aetiology, clinical features and therapy. ( 21999222 )
2012
21
Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. ( 21895787 )
2012
22
Otomycosis with Perforated Tympanic Membrane: Self medication with Topical Antifungal Solution versus Medicated Ear Wick. ( 23267306 )
2012
23
Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review. ( 22430336 )
2012
24
A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). ( 22529649 )
2011
25
Otomycosis due to filamentous fungi. ( 21499908 )
2011
26
Antibiotic resistance and otomycosis in the draining ear: culture results by diagnosis. ( 21041003 )
2011
27
Otomycosis in central iran: a clinical and mycological study. ( 22737432 )
2011
28
Chronic otomycosis due to malassezia spp. ( 20606976 )
2010
29
Otomycosis: Diagnosis and treatment. ( 20347664 )
2010
30
Prevalence of otomycosis in Ibadan: a review of laboratory reports. ( 22420052 )
2010
31
Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus. ( 20409075 )
2010
32
Otomycosis due to Aspergillus spp. in a dog: case report and literature review. ( 20492628 )
2010
33
Otomycosis: a retrospective study. ( 19649486 )
2009
34
Otomycosis in western Nigeria. ( 18076598 )
2008
35
Ototopical antifungals and otomycosis: a review. ( 18279975 )
2008
36
Aspergillus otomycosis in an immunocompromised patient. ( 19006061 )
2008
37
In vitro susceptibilities of Aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole. ( 17944704 )
2007
38
Outer limits. An overview of otomycosis. ( 20014678 )
2007
39
Scedosporium apiospermum otomycosis. ( 17606042 )
2007
40
Suction clearance and 2% topical miconazole versus the same combination with acidic drops in the treatment of otomycosis. ( 17883017 )
2007
41
Otomycosis: clinical features and treatment implications. ( 17071313 )
2006
42
Otomycosis: subdermal growth in calcified mass. ( 16799802 )
2006
43
Otomycosis: clinical and mycological study of 97 cases. ( 17315791 )
2006
44
Topical antibiotic induced otomycosis. ( 15885342 )
2005
45
In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis. ( 15310330 )
2004
46
Chronic bilateral otomycosis caused by Aspergillus niger. ( 14998406 )
2004
47
A case of otomycosis caused by Aspergillus sclerotiorum. ( 15729874 )
2004
48
Concomitant otomycosis and dermatomycoses: a clinical and microbiological study. ( 12520352 )
2003
49
Otomycosis in Turkey: predisposing factors, aetiology and therapy. ( 12590854 )
2003
50
Prevalence of otomycosis in outpatient department of otolaryngology in Tribhuvan University Teaching Hospital, Kathmandu, Nepal. ( 12731637 )
2003
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Variations for Otomycosis

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Expression for Otomycosis

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Search GEO for disease gene expression data for Otomycosis.
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Pathways for Otomycosis

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Pathways related to Otomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Super pathways Score Top Affiliating Genes
1
Integrin Pathway 60
Show member pathways
 13.28 CALM1 CALM2 CALM3 CD99 CXCL14
2
Response to elevated platelet cytosolic Ca2+ 62
Show member pathways
 13.19 CALM1 CALM2 CALM3 CD99 FLNA
3
Signaling by Rho GTPases 62
Show member pathways
 12.91 CALM1 CALM2 CALM3 FLNA
4
Actin Nucleation by ARP-WASP Complex 60
Show member pathways
 12.88 CALM1 CALM2 CALM3 FLNA
5
CCR5 Pathway in Macrophages 60
Show member pathways
 12.76 CALM1 CALM2 CALM3 CXCL14
6
Aquaporin-mediated transport 62
Show member pathways
 12.34 CALM1 CALM2 CALM3
7
CLEC7A (Dectin-1) signaling 62
Show member pathways
 12.33 CALM1 CALM2 CALM3
8
Presynaptic function of Kainate receptors 62
Show member pathways
 12.32 CALM1 CALM2 CALM3
9
Insulin secretion 37
Show member pathways
 12.31 CALM1 CALM2 CALM3
10
RhoGDI Pathway 60
Show member pathways
 12.3 CALM1 CALM2 CALM3
11
ICos-ICosL Pathway in T-Helper Cell 60
Show member pathways
 12.29 CALM1 CALM2 CALM3
12
B cell receptor signaling pathway (KEGG) 1
Show member pathways
 12.28 CALM1 CALM2 CALM3
13
Semaphorin interactions 62
Show member pathways
 12.27 CALM1 CALM2 CALM3 FLNA
14
Dopamine-DARPP32 Feedback onto cAMP Pathway 60
12.26 CALM1 CALM2 CALM3
15
Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways 61
Show member pathways
 12.26 CALM1 CALM2 CALM3
16
Immune response CCR3 signaling in eosinophils 21
Show member pathways
 12.25 CALM1 CALM2 CALM3
17
Oocyte meiosis 37
Show member pathways
 12.24 CALM1 CALM2 CALM3
18
B Cell Receptor Signaling Pathway (sino) 63
Show member pathways
 12.23 CALM1 CALM2 CALM3
19
Metabolism of fat-soluble vitamins 62
Show member pathways
 12.23 CALM1 CALM2 CALM3
20
Development Ligand-independent activation of ESR1 and ESR2 21
Show member pathways
 12.22 CALM1 CALM2 CALM3
21
cAMP signaling pathway 37
Show member pathways
 12.19 CALM1 CALM2 CALM3
22
Platelet homeostasis 62
Show member pathways
 12.16 CALM1 CALM2 CALM3
23
Toll Comparative Pathway 60
Show member pathways
 12.16 CALM1 CALM2 CALM3
24
Calcium signaling pathway 37
Show member pathways
 12.15 CALM1 CALM2 CALM3
25
Post NMDA receptor activation events 62
Show member pathways
 12.13 CALM1 CALM2 CALM3
26
Tuberculosis 37
12.13 CALM1 CALM2 CALM3
27
CD28 co-stimulation 62
Show member pathways
 12.11 CALM1 CALM2 CALM3
28
Long-term potentiation 37
Show member pathways
 12.1 CALM1 CALM2 CALM3
29
Salivary secretion 37
Show member pathways
 12.08 CALM1 CALM2 CALM3
30
ADP signalling through P2Y purinoceptor 1 62
Show member pathways
 12.06 CALM1 CALM2 CALM3
31
Phototransduction 37
Show member pathways
 12.05 CALM1 CALM2 CALM3
32
Immune response Function of MEF2 in T lymphocytes 21
Show member pathways
 12.03 CALM1 CALM2 CALM3
33
Fluid shear stress and atherosclerosis 37
11.99 CALM1 CALM2 CALM3
34
Apelin signaling pathway 37
11.99 CALM1 CALM2 CALM3
35
Translation Translation regulation by Alpha-1 adrenergic receptors 21
Show member pathways
 11.92 CALM1 CALM2 CALM3
36
Amphetamine addiction 37
Show member pathways
 11.91 CALM1 CALM2 CALM3
37
Inositol phosphate metabolism (REACTOME) 62
Show member pathways
 11.89 CALM1 CALM2 CALM3
38
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 62
Show member pathways
 11.85 CALM1 CALM2 CALM3
39
Glucagon signaling pathway 37
11.84 CALM1 CALM2 CALM3
40
ErbB1 downstream signaling 1
11.83 CALM1 CALM2 CALM3
41
Development EPO-induced Jak-STAT pathway 21
Show member pathways
 11.8 CALM1 CALM2 CALM3
42
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.77 CALM1 CALM2 CALM3
43
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 21
Show member pathways
 11.76 CALM1 CALM2 CALM3
44
Immune response IFN gamma signaling pathway 21
Show member pathways
 11.71 CALM1 CALM2 CALM3
45
Uptake and actions of bacterial toxins 62
Show member pathways
 11.7 CALM1 CALM2 CALM3
46
eNOS activation and regulation 62
Show member pathways
 11.69 CALM1 CALM2 CALM3
47
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.67 CALM1 CALM2 CALM3
48
Pertussis 37
11.66 CALM1 CALM2 CALM3
49
Phase 0 - rapid depolarisation 62
Show member pathways
 11.65 CALM1 CALM2 CALM3
50
Signal transduction_Erk Interactions- Inhibition of Erk 21
11.64 CALM1 CALM2 CALM3
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GO Terms for Otomycosis

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Cellular components related to Otomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.54 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.5 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.43 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.33 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.13 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Otomycosis according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.87 CALM1 CALM2 CALM3 FLNA
2 ion transmembrane transport GO:0034220 9.82 CALM1 CALM2 CALM3
3 Fc-epsilon receptor signaling pathway GO:0038095 9.81 CALM1 CALM2 CALM3
4 muscle contraction GO:0006936 9.81 CALM1 CALM2 CALM3
5 response to calcium ion GO:0051592 9.8 CALM1 CALM2 CALM3
6 inositol phosphate metabolic process GO:0043647 9.8 CALM1 CALM2 CALM3
7 substantia nigra development GO:0021762 9.79 CALM1 CALM2 CALM3
8 protein methylation GO:0006479 9.79 CALM1 CALM2 CALM3
9 positive regulation of protein serine/threonine kinase activity GO:0071902 9.78 CALM1 CALM2 CALM3
10 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.77 CALM1 CALM2 CALM3
11 regulation of heart rate GO:0002027 9.77 CALM1 CALM2 CALM3
12 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.76 CALM1 CALM2 CALM3
13 regulation of rhodopsin mediated signaling pathway GO:0022400 9.75 CALM1 CALM2 CALM3
14 regulation of nitric-oxide synthase activity GO:0050999 9.73 CALM1 CALM2 CALM3
15 positive regulation of protein autophosphorylation GO:0031954 9.72 CALM1 CALM2 CALM3
16 regulation of cytokinesis GO:0032465 9.71 CALM1 CALM2 CALM3
17 regulation of cardiac muscle contraction GO:0055117 9.7 CALM1 CALM2 CALM3
18 positive regulation of protein dephosphorylation GO:0035307 9.69 CALM1 CALM2 CALM3
19 glycogen catabolic process GO:0005980 9.67 CALM1 CALM2 CALM3
20 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
21 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.63 CALM1 CALM2 CALM3
22 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
23 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
24 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
25 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
26 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
27 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
28 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
29 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Otomycosis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.73 CALM1 CALM2 CALM3 FLNA
2 protein domain specific binding GO:0019904 9.69 CALM1 CALM2 CALM3
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.65 CALM1 CALM2 CALM3
4 ligand-gated ion channel activity GO:0015276 9.63 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
6 phospholipase binding GO:0043274 9.54 CALM1 CALM2 CALM3
7 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
8 thioesterase binding GO:0031996 9.43 CALM1 CALM2 CALM3
9 inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 9.33 CALM1 CALM2 CALM3
10 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
11 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3
12 protein binding GO:0005515 10.19 BRD4 CALM1 CALM2 CALM3 CBS CD99
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Sources for Otomycosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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