MCID: OTS001
MIFTS: 35

Otosclerosis malady

Categories: Genetic diseases, Ear diseases, Rare diseases

Aliases & Classifications for Otosclerosis

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Aliases & Descriptions for Otosclerosis:

Name: Otosclerosis 11 24 27 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12185
ICD9CM32 387.8

Summaries for Otosclerosis

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Wikipedia:71 Otosclerosis or otospongiosis is an abnormal growth of bone near the middle ear. It can result in... more...

MalaCards based summary: Otosclerosis is related to otosclerosis 1 and otosclerosis 10, and has symptoms including earache and earache. An important gene associated with Otosclerosis is COL1A1 (Collagen Type I Alpha 1 Chain). Affiliated tissues include bone, testes and t cells.

Disease Ontology:11 An otitis interna characterized by an abnormal bone growth in the middle ear.

Related Diseases for Otosclerosis

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Graphical network of the top 20 diseases related to Otosclerosis:



Diseases related to otosclerosis

Symptoms & Phenotypes for Otosclerosis

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UMLS symptoms related to Otosclerosis:


earache

Drugs & Therapeutics for Otosclerosis

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Drugs for Otosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcysteineapprovedPhase 4316616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
2N-monoacetylcystinePhase 4316
3Respiratory System AgentsPhase 44818
4Protective AgentsPhase 47190
5ExpectorantsPhase 4388
6Antiviral AgentsPhase 49732
7Anti-Infective AgentsPhase 421402
8AntidotesPhase 41038
9AntioxidantsPhase 42928
10Tiludronic acidPhase 32
11Bone Density Conservation AgentsPhase 33266
12DiphosphonatesPhase 3446

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Efficacy of Acetylcysteine in Patients Undergoing Surgery for OtosclerosisCompletedNCT00525551Phase 4
2Audiometric Parameters in Conductive Hearing Loss and Middle Ear DiseaseUnknown statusNCT00222417Phase 2, Phase 3
3Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot StudyRecruitingNCT02456272Phase 3
4Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced OtosclerosisTerminatedNCT01617057Phase 3
5Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS)RecruitingNCT02435446Phase 1
6Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
7Quantification of Prosthesis Penetration With Conebeam in OtosclerosisCompletedNCT02901093
8Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
9Clinical Assessment of the External Sound Processor Worn by Patients Implanted With CodacsCompletedNCT02156167
10Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
11Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Otosclerosis

Genetic Tests for Otosclerosis

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Genetic tests related to Otosclerosis:

id Genetic test Affiliating Genes
1 Otosclerosis27 24

Anatomical Context for Otosclerosis

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MalaCards organs/tissues related to Otosclerosis:

36
Bone, Testes, T cells, Cortex, Eye

Publications for Otosclerosis

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Articles related to Otosclerosis:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Otosclerosis: An update on diagnosis and treatment. (28060022)
2017
2
Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth? (27851656)
2017
3
Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis. (28090791)
2017
4
Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome. (28068300)
2017
5
3D-Flair sequence at 3T in cochlear otosclerosis. (26747254)
2016
6
Otosclerosis Associated with a De Novo Mutation -832Ga88>a88A in the TGFB1 Gene Promoter Causing a Decreased Expression Level. (27404893)
2016
7
A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis. (26649602)
2016
8
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial. (26924941)
2016
9
Mutations and altered expression of SERPINF1 in patients with familial otosclerosis. (27056980)
2016
10
Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling. (27034709)
2016
11
Evaluation of Functional Outcomes after Stapes Surgery in Patients with Clinical Otosclerosis in a Teaching Institution. (26722344)
2016
12
Juvenile otosclerosis: a case presentation and review of the literature. (27084899)
2016
13
Flexible Fiber Optic Carbon-Dioxide Laser Assisted Stapedotomy in Otosclerosis. (27725835)
2016
14
Diode Laser Stapedotomy vs Conventional Stapedotomy in Otosclerosis: A Double-Blinded Randomized Clinical Trial. (26980905)
2016
15
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. (27386930)
2016
16
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report. (27106776)
2016
17
Does stapes surgery improve tinnitus in patients with otosclerosis? (27553985)
2016
18
Stapedotomy vs Cochlear Implantation for Advanced Otosclerosis: Systematic Review and Meta-analysis. (27329418)
2016
19
Relation of otosclerosis and osteoporosis: A bone mineral density study. (26656733)
2016
20
Long-term Incidence and Degree of Sensorineural Hearing Loss in Otosclerosis. (27755362)
2016
21
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients. (26804928)
2016
22
Vestibular Disorders after Stapedial Surgery in Patients with Otosclerosis. (26904127)
2016
23
Oxidative stress in otosclerosis. (27387094)
2016
24
How Often Does Stapedectomy for Otosclerosis Result in Endolymphatic Hydrops? (27380537)
2016
25
Update on the imaging diagnosis of otosclerosis. (27267384)
2016
26
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. (27383734)
2016
27
Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis. (27676652)
2016
28
Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. (26841857)
2016
29
Obliquity of the Stapes in Otosclerosis: A New Radiological Sign. (27096011)
2016
30
Diagnostic efficacy and therapeutic impact of computed tomography in the evaluation of clinically suspected otosclerosis. (27364152)
2016
31
The Effect of Piston Diameter in Stapedotomy for Otosclerosis: A Temporal Bone Model. (27642666)
2016
32
A systematic review of the effect of different crimping techniques in stapes surgery for otosclerosis. (26333166)
2015
33
Otosclerosis and Fitness to Fly. (26630051)
2015
34
A meta-analysis of surgical success rates in Congenital stapes fixation and juvenile otosclerosis. (25963343)
2015
35
HISTORY OF THE SURGERY FOR OTOSCLEROSIS AND COCHLEAR IMPLANTS. (26234021)
2015
36
Otosclerosis: Shift in bone conduction after stapedotomy. (26601550)
2015
37
Primary stapedotomy in children with otosclerosis: A prospective study of 41 consecutive cases. (26016603)
2015
38
Binaural cochlear implantation for a case of labyrinthine otosclerosis. (26708249)
2015
39
The pathophysiology of otosclerosis: Review of current research. (26276418)
2015
40
Genetic association and altered gene expression of osteoprotegerin in otosclerosis patients. (25998045)
2015
41
Audiometric Results after Stapedotomy Operations in Patients with Otosclerosis and Preoperative Small Air-Bone Gaps. (26316134)
2015
42
Numerical study of Hough technique in surgery of otosclerosis, using the finite element method. (26899201)
2015
43
Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study. (26309142)
2015
44
Decisive criteria between stapedotomy and cochlear implantation in patients with far advanced otosclerosis. (25548892)
2015
45
Bone Mineral Density Measurements in Otosclerosis Using Dual-Energy X-Ray Absorptiometry. (26096174)
2015
46
Identification of Target Proteins Involved in Cochlear Otosclerosis. (25569361)
2015
47
A systematic review of the effect of piston diameter in stapes surgery for otosclerosis on hearing results. (26108164)
2015
48
Differences in Postoperative Hearing Outcomes and Vertigo in Patients with Otosclerosis Treated with Laser-Assisted Stapedotomy versus Stapedectomy. (26345411)
2015
49
Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis? (26571406)
2015
50
Factors affecting postoperative outcome in otosclerosis patients: Predictive role of audiological and clinical features. (25857423)
2015

Variations for Otosclerosis

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Expression for genes affiliated with Otosclerosis

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Search GEO for disease gene expression data for Otosclerosis.

Pathways for genes affiliated with Otosclerosis

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GO Terms for genes affiliated with Otosclerosis

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Sources for Otosclerosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet