MCID: OTS001
MIFTS: 35

Otosclerosis malady

Categories: Ear diseases, Genetic diseases

Aliases & Classifications for Otosclerosis

Aliases & Descriptions for Otosclerosis:

Name: Otosclerosis 12 24 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12185
ICD9CM 35 387.8
SNOMED-CT 64 194382008 194691004
UMLS 69 C0029696

Summaries for Otosclerosis

Disease Ontology : 12 An otitis interna characterized by an abnormal bone growth in the middle ear.

MalaCards based summary : Otosclerosis is related to otosclerosis 1 and otosclerosis 10, and has symptoms including earache An important gene associated with Otosclerosis is COL1A1 (Collagen Type I Alpha 1 Chain). The drugs Acetylcysteine and Antidotes have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells.

Wikipedia : 71 Otosclerosis or otospongiosis is an abnormal growth of bone near the middle ear. It can result in... more...

Related Diseases for Otosclerosis

Graphical network of the top 20 diseases related to Otosclerosis:



Diseases related to Otosclerosis

Symptoms & Phenotypes for Otosclerosis

UMLS symptoms related to Otosclerosis:


earache

Drugs & Therapeutics for Otosclerosis

Drugs for Otosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2 Antidotes Phase 4
3 Anti-Infective Agents Phase 4
4 Antioxidants Phase 4
5 Antiviral Agents Phase 4
6 Expectorants Phase 4
7 N-monoacetylcystine Phase 4
8 Protective Agents Phase 4
9 Respiratory System Agents Phase 4
10
tiludronate Approved, Vet_approved Phase 3 89987-06-4 60937
11 Bone Density Conservation Agents Phase 3
12 Diphosphonates Phase 3

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis Completed NCT00525551 Phase 4
2 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417 Phase 2, Phase 3
3 Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot Study Recruiting NCT02456272 Phase 3
4 Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced Otosclerosis Terminated NCT01617057 Phase 3
5 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
6 Quantification of Prosthesis Penetration With Conebeam in Otosclerosis Completed NCT02901093
7 Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively Completed NCT02554422
8 Clinical Assessment of the External Sound Processor Worn by Patients Implanted With Codacs Completed NCT02156167
9 Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
10 Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS) Recruiting NCT02435446
11 Comprehensive Wide Bandwidth Test Battery of Auditory Function in Veterans Enrolling by invitation NCT02019888

Search NIH Clinical Center for Otosclerosis

Genetic Tests for Otosclerosis

Genetic tests related to Otosclerosis:

id Genetic test Affiliating Genes
1 Otosclerosis 29 24

Anatomical Context for Otosclerosis

MalaCards organs/tissues related to Otosclerosis:

39
Bone, Testes, T Cells, Cortex, Eye

Publications for Otosclerosis

Articles related to Otosclerosis:

(show top 50) (show all 575)
id Title Authors Year
1
Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis. ( 28090791 )
2017
2
Otosclerosis: An update on diagnosis and treatment. ( 28060022 )
2017
3
Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth? ( 27851656 )
2017
4
Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome. ( 28068300 )
2017
5
Erratum to: Diagnostic value of cone-beam CT in histologically confirmed otosclerosis. ( 27130206 )
2016
6
Otosclerosis Associated with a De Novo Mutation -832Ga88>a88A in the TGFB1 Gene Promoter Causing a Decreased Expression Level. ( 27404893 )
2016
7
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. ( 27383734 )
2016
8
Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. ( 26841857 )
2016
9
Mutations and altered expression of SERPINF1 in patients with familial otosclerosis. ( 27056980 )
2016
10
Stapedotomy vs Cochlear Implantation for Advanced Otosclerosis: Systematic Review and Meta-analysis. ( 27329418 )
2016
11
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. ( 27386930 )
2016
12
Update on the imaging diagnosis of otosclerosis. ( 27267384 )
2016
13
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report. ( 27106776 )
2016
14
Juvenile otosclerosis: a case presentation and review of the literature. ( 27084899 )
2016
15
Relation of otosclerosis and osteoporosis: A bone mineral density study. ( 26656733 )
2016
16
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients. ( 26804928 )
2016
17
Long-term Incidence and Degree of Sensorineural Hearing Loss in Otosclerosis. ( 27755362 )
2016
18
Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling. ( 27034709 )
2016
19
Evaluation of Functional Outcomes after Stapes Surgery in Patients with Clinical Otosclerosis in a Teaching Institution. ( 26722344 )
2016
20
The Effect of Piston Diameter in Stapedotomy for Otosclerosis: A Temporal Bone Model. ( 27642666 )
2016
21
Flexible Fiber Optic Carbon-Dioxide Laser Assisted Stapedotomy in Otosclerosis. ( 27725835 )
2016
22
Obliquity of the Stapes in Otosclerosis: A New Radiological Sign. ( 27096011 )
2016
23
Vestibular Disorders after Stapedial Surgery in Patients with Otosclerosis. ( 26904127 )
2016
24
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial. ( 26924941 )
2016
25
3D-Flair sequence at 3T in cochlear otosclerosis. ( 26747254 )
2016
26
Diode Laser Stapedotomy vs Conventional Stapedotomy in Otosclerosis: A Double-Blinded Randomized Clinical Trial. ( 26980905 )
2016
27
How Often Does Stapedectomy for Otosclerosis Result in Endolymphatic Hydrops? ( 27380537 )
2016
28
Diagnostic efficacy and therapeutic impact of computed tomography in the evaluation of clinically suspected otosclerosis. ( 27364152 )
2016
29
Oxidative stress in otosclerosis. ( 27387094 )
2016
30
A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis. ( 26649602 )
2016
31
Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis. ( 27676652 )
2016
32
Does stapes surgery improve tinnitus in patients with otosclerosis? ( 27553985 )
2016
33
Bone Mineral Density Measurements in Otosclerosis Using Dual-Energy X-Ray Absorptiometry. ( 26096174 )
2015
34
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery. ( 26567711 )
2015
35
A systematic review of the effect of piston diameter in stapes surgery for otosclerosis on hearing results. ( 26108164 )
2015
36
Identification of Target Proteins Involved in Cochlear Otosclerosis. ( 25569361 )
2015
37
Factors affecting postoperative outcome in otosclerosis patients: Predictive role of audiological and clinical features. ( 25857423 )
2015
38
Otosclerosis Without Stapes Fixation. ( 25839982 )
2015
39
Primary stapedotomy in children with otosclerosis: A prospective study of 41 consecutive cases. ( 26016603 )
2015
40
Book review: review of otosclerosis diagnosis, evaluation, pathology, surgical techniques, and outcomes. ( 25670834 )
2015
41
Anatomopathology of the superstructure of the stapes in patients with otosclerosis. ( 25992143 )
2015
42
Audiometric Results after Stapedotomy Operations in Patients with Otosclerosis and Preoperative Small Air-Bone Gaps. ( 26316134 )
2015
43
Binaural cochlear implantation for a case of labyrinthine otosclerosis. ( 26708249 )
2015
44
Otosclerosis: Shift in bone conduction after stapedotomy. ( 26601550 )
2015
45
Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study. ( 26309142 )
2015
46
Differences in Postoperative Hearing Outcomes and Vertigo in Patients with Otosclerosis Treated with Laser-Assisted Stapedotomy versus Stapedectomy. ( 26345411 )
2015
47
HISTORY OF THE SURGERY FOR OTOSCLEROSIS AND COCHLEAR IMPLANTS. ( 26234021 )
2015
48
A meta-analysis of surgical success rates in Congenital stapes fixation and juvenile otosclerosis. ( 25963343 )
2015
49
A systematic review of the effect of different crimping techniques in stapes surgery for otosclerosis. ( 26333166 )
2015
50
Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis? ( 26571406 )
2015

Variations for Otosclerosis

Expression for Otosclerosis

Search GEO for disease gene expression data for Otosclerosis.

Pathways for Otosclerosis

GO Terms for Otosclerosis

Sources for Otosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....