MCID: OTS001
MIFTS: 35

Otosclerosis malady

Categories: Genetic diseases (common), Ear diseases

Aliases & Classifications for Otosclerosis

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Aliases & Descriptions for Otosclerosis:

Name: Otosclerosis 11 24 27 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12185
ICD9CM32 387.8

Summaries for Otosclerosis

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Wikipedia:71 Otosclerosis or otospongiosis is an abnormal growth of bone near the middle ear. It can result in... more...

MalaCards based summary: Otosclerosis is related to otosclerosis 1 and otosclerosis 10, and has symptoms including earache and earache. An important gene associated with Otosclerosis is COL1A1 (Collagen Type I Alpha 1 Chain). Affiliated tissues include bone, testes and t cells.

Disease Ontology:11 An otitis interna characterized by an abnormal bone growth in the middle ear.

Related Diseases for Otosclerosis

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Graphical network of the top 20 diseases related to Otosclerosis:



Diseases related to otosclerosis

Symptoms & Phenotypes for Otosclerosis

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UMLS symptoms related to Otosclerosis:


earache

Drugs & Therapeutics for Otosclerosis

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Drugs for Otosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Acetylcysteineapproved, investigationalPhase 4330616-91-112035
Synonyms:
(2R)-2-acetylamino-3-sulfanylpropanoic acid
(R)-2-acetylamino-3-mercaptopropanoic acid
(R)-mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
Fluprowit
 
L-Acetylcysteine
L-acetylcysteine
L-╬▒-acetamido-╬▓-mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetyl-L-(+)-cysteine
N-acetyl-L-cysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
2N-monoacetylcystinePhase 4330
3Respiratory System AgentsPhase 44997
4Protective AgentsPhase 47443
5ExpectorantsPhase 4404
6Antiviral AgentsPhase 49967
7Anti-Infective AgentsPhase 422062
8AntidotesPhase 41071
9AntioxidantsPhase 43050
10
tiludronateapproved, vet_approvedPhase 3289987-06-460937
Synonyms:
Acide tiludronique
Acide tiludronique [INN-French]
Acido tiludronico
Acido tiludronico [INN-Spanish]
Acidum tiludronicum
 
Acidum tiludronicum [INN-Latin]
Skelid
Tiludronate
Tiludronate disodium
Tiludronic Acid Disodium Salt
Tiludronic acid
11Bone Density Conservation AgentsPhase 33376
12DiphosphonatesPhase 3450

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Efficacy of Acetylcysteine in Patients Undergoing Surgery for OtosclerosisCompletedNCT00525551Phase 4
2Audiometric Parameters in Conductive Hearing Loss and Middle Ear DiseaseUnknown statusNCT00222417Phase 2, Phase 3
3Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot StudyRecruitingNCT02456272Phase 3
4Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced OtosclerosisTerminatedNCT01617057Phase 3
5Taste Disorders in Middle Ear Disease and After Middle Ear SurgeryUnknown statusNCT01584011
6Quantification of Prosthesis Penetration With Conebeam in OtosclerosisCompletedNCT02901093
7Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument IntraoperativelyCompletedNCT02554422
8Clinical Assessment of the External Sound Processor Worn by Patients Implanted With CodacsCompletedNCT02156167
9Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower DoseCompletedNCT01855425
10Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS)RecruitingNCT02435446
11Comprehensive Wide Bandwidth Test Battery of Auditory Function in VeteransEnrolling by invitationNCT02019888

Search NIH Clinical Center for Otosclerosis

Genetic Tests for Otosclerosis

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Genetic tests related to Otosclerosis:

id Genetic test Affiliating Genes
1 Otosclerosis27 24

Anatomical Context for Otosclerosis

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MalaCards organs/tissues related to Otosclerosis:

36
Bone, Testes, T cells, Cortex, Eye

Publications for Otosclerosis

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Articles related to Otosclerosis:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis. (28090791)
2017
2
Otosclerosis: An update on diagnosis and treatment. (28060022)
2017
3
Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth? (27851656)
2017
4
Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome. (28068300)
2017
5
Erratum to: Diagnostic value of cone-beam CT in histologically confirmed otosclerosis. (27130206)
2016
6
Otosclerosis Associated with a De Novo Mutation -832Ga88>a88A in the TGFB1 Gene Promoter Causing a Decreased Expression Level. (27404893)
2016
7
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. (27383734)
2016
8
Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. (26841857)
2016
9
Mutations and altered expression of SERPINF1 in patients with familial otosclerosis. (27056980)
2016
10
Stapedotomy vs Cochlear Implantation for Advanced Otosclerosis: Systematic Review and Meta-analysis. (27329418)
2016
11
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. (27386930)
2016
12
Update on the imaging diagnosis of otosclerosis. (27267384)
2016
13
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report. (27106776)
2016
14
Juvenile otosclerosis: a case presentation and review of the literature. (27084899)
2016
15
Relation of otosclerosis and osteoporosis: A bone mineral density study. (26656733)
2016
16
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients. (26804928)
2016
17
Long-term Incidence and Degree of Sensorineural Hearing Loss in Otosclerosis. (27755362)
2016
18
Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling. (27034709)
2016
19
Evaluation of Functional Outcomes after Stapes Surgery in Patients with Clinical Otosclerosis in a Teaching Institution. (26722344)
2016
20
The Effect of Piston Diameter in Stapedotomy for Otosclerosis: A Temporal Bone Model. (27642666)
2016
21
Flexible Fiber Optic Carbon-Dioxide Laser Assisted Stapedotomy in Otosclerosis. (27725835)
2016
22
Obliquity of the Stapes in Otosclerosis: A New Radiological Sign. (27096011)
2016
23
Vestibular Disorders after Stapedial Surgery in Patients with Otosclerosis. (26904127)
2016
24
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial. (26924941)
2016
25
3D-Flair sequence at 3T in cochlear otosclerosis. (26747254)
2016
26
Diode Laser Stapedotomy vs Conventional Stapedotomy in Otosclerosis: A Double-Blinded Randomized Clinical Trial. (26980905)
2016
27
How Often Does Stapedectomy for Otosclerosis Result in Endolymphatic Hydrops? (27380537)
2016
28
Diagnostic efficacy and therapeutic impact of computed tomography in the evaluation of clinically suspected otosclerosis. (27364152)
2016
29
Oxidative stress in otosclerosis. (27387094)
2016
30
A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis. (26649602)
2016
31
Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis. (27676652)
2016
32
Does stapes surgery improve tinnitus in patients with otosclerosis? (27553985)
2016
33
Bone Mineral Density Measurements in Otosclerosis Using Dual-Energy X-Ray Absorptiometry. (26096174)
2015
34
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery. (26567711)
2015
35
A systematic review of the effect of piston diameter in stapes surgery for otosclerosis on hearing results. (26108164)
2015
36
Identification of Target Proteins Involved in Cochlear Otosclerosis. (25569361)
2015
37
Factors affecting postoperative outcome in otosclerosis patients: Predictive role of audiological and clinical features. (25857423)
2015
38
Otosclerosis Without Stapes Fixation. (25839982)
2015
39
Primary stapedotomy in children with otosclerosis: A prospective study of 41 consecutive cases. (26016603)
2015
40
Book review: review of otosclerosis diagnosis, evaluation, pathology, surgical techniques, and outcomes. (25670834)
2015
41
Anatomopathology of the superstructure of the stapes in patients with otosclerosis. (25992143)
2015
42
Audiometric Results after Stapedotomy Operations in Patients with Otosclerosis and Preoperative Small Air-Bone Gaps. (26316134)
2015
43
Binaural cochlear implantation for a case of labyrinthine otosclerosis. (26708249)
2015
44
Otosclerosis: Shift in bone conduction after stapedotomy. (26601550)
2015
45
Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study. (26309142)
2015
46
Differences in Postoperative Hearing Outcomes and Vertigo in Patients with Otosclerosis Treated with Laser-Assisted Stapedotomy versus Stapedectomy. (26345411)
2015
47
HISTORY OF THE SURGERY FOR OTOSCLEROSIS AND COCHLEAR IMPLANTS. (26234021)
2015
48
A meta-analysis of surgical success rates in Congenital stapes fixation and juvenile otosclerosis. (25963343)
2015
49
A systematic review of the effect of different crimping techniques in stapes surgery for otosclerosis. (26333166)
2015
50
Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis? (26571406)
2015

Variations for Otosclerosis

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Expression for genes affiliated with Otosclerosis

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Search GEO for disease gene expression data for Otosclerosis.

Pathways for genes affiliated with Otosclerosis

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GO Terms for genes affiliated with Otosclerosis

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Sources for Otosclerosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet