Otosclerosis malady

Wikipedia: Otosclerosis is an abnormal growth of bone near the middle ear. It can result in hearing loss.⁴⁴ more...

MalaCards: Otosclerosis is related to otosclerosis, familial and diastrophic dysplasia. An important gene associated with Otosclerosis is OTSC5 (otosclerosis 5), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Actin-Based Motility by Rho Family GTPases. The compounds teriparatide and titanium have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are liver/biliary system and craniofacial.

Aliases & Descriptions:

otosclerosis 6 7 16 8 32 43

Disease types for otosclerosis family:

otosclerosis 1	otosclerosis 2
otosclerosis 3	otosclerosis 4
otosclerosis 5	otosclerosis 7
otosclerosis 8

Diseases related to otosclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 241)

id	Related Disease	Score	Top Affiliating Genes
1	otosclerosis, familial	32.2	OTSC5, OTSC7, COL1A2
2	diastrophic dysplasia	28.7	BMP2, IL6, TGFB1, SLC26A2
3	osteogenesis imperfecta	28.5	BMP2, BMP3, CD36, PTH1R, COL1A1, COL1A2
4	ankylosis	26.9	BMP2, TNFRSF11B, PTH1R, NOG, NOTCH1, TGFB1
5	aldosteronism	25.6	BMP2, BMP4, CD36, IL6, COL1A1, COL1A2
6	osteoporosis	24.7	BMP2, BMP4, CD36, IL6, TNFRSF11B, PTH1R
7	col1a1/2-related osteogenesis imperfecta	13.7	COL1A1, COL1A2
8	osteogenesis imperfecta type 4	13.7	COL1A1, COL1A2
9	ehlers-danlos syndrome type viib	13.7	CD36, COL1A2
10	caffey disease	13.6	CD36, COL1A1
11	ehlers-danlos syndrome type viia	13.6	CD36, COL1A1, COL1A2
12	osteogenesis imperfecta, type ii	13.6	CD36, COL1A1, COL1A2
13	osteogenesis imperfecta type i	13.6	CD36, COL1A1, COL1A2
14	osteogenesis imperfecta type iii	13.6	CD36, COL1A1, COL1A2
15	hyperostosis	13.4	TNFRSF11B, COL1A1, TGFB1
16	dentinogenesis imperfecta	13.4	CD36, COL1A1, COL1A2
17	osteoporosis, postmenopausal	13.4	CD36, TNFRSF11B, COL1A1
18	epiphyseal dysplasia	13.4	CD36, PTH1R, SLC26A2
19	alport syndrome	13.4	COL1A1, COL1A2, TGFB1
20	multiple epiphyseal dysplasia	13.4	CD36, PTH1R, SLC26A2
21	oral submucous fibrosis	13.4	CD36, COL1A1, COL1A2, TGFB1
22	usual interstitial pneumonia	13.3	COL1A1, AGTR1, TGFB1
23	bone cancer	13.3	CD36, TNFRSF11B, COL1A1
24	progressive osseous heteroplasia	13.2	BMP2, BMP4, NOG
25	hip dysplasia	13.2	IL6, TGFB1, SLC26A2
26	osteopenia/osteoporosis	13.2	BMP2, CD36, TNFRSF11B, COL1A2
27	marfan syndrome	13.2	CD36, COL1A2, AGTR1, TGFB1
28	osteomalacia	13.2	BMP3, CD36, TNFRSF11B, PTH1R
29	chondrodysplasia	13.1	CD36, PTH1R, COL1A1, SLC26A2
30	aortic valve stenosis	13.1	BMP2, TNFRSF11B, AGT
31	fibrodysplasia ossificans progressiva	13.1	BMP2, BMP4, NOG
32	bullous keratopathy	13.1	BMP2, BMP4, TGFB1
33	synostosis	13.1	BMP2, BMP4, NOG
34	poems syndrome	13.1	CD36, IL6, TNFRSF11B
35	collagen disease	13.1	CD36, IL6, COL1A1
36	rickets	13.0	CD36, IL6, TNFRSF11B
37	pilomatrixoma	13.0	BMP2, BMP4
38	keloids	13.0	CD36, SP1, TGFB1
39	myelofibrosis	13.0	BMP2, TNFRSF11B, NOG, TGFB1
40	alcoholic liver cirrhosis	12.9	CD36, IL6, TNFRSF11B, TGFB1
41	cerebral aneurysms	12.9	IL6, COL1A2, AGTR1
42	renal osteodystrophy	12.9	CD36, IL6, TNFRSF11B, PTH1R
43	periostitis	12.9	BMP2, BMP4, CD36, TNFRSF11B, TGFB1
44	biliary atresia	12.8	CD36, IL6, TNFRSF11B, TGFB1
45	cholesteatoma	12.8	IL6, TNFRSF11B, TGFB1, A1BG
46	proliferative glomerulonephritis	12.8	CD36, IL6, AGTR1, TGFB1
47	ossification of posterior longitudinal ligament of spine	12.8	BMP2, BMP4, CD36, PTH1R, TGFB1
48	secondary syphilis	12.8	BMP2, BMP4, CD36, TNFRSF11B, PTH1R
49	hypercalcemia	12.7	CD36, IL6, TNFRSF11B, PTH1R
50	primary hyperparathyroidism	12.7	CD36, IL6, TNFRSF11B, PTH1R, COL1A1

Approved drugs:

Drug clinical trials:

Genetic tests related to otosclerosis:

id	Genetic test	Affiliating Genes
1	Otosclerosis clinical/research

MalaCards organs/tissues related to otosclerosis:

²²

MGI Mouse Phenotypes related to otosclerosis:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.2	AGT, IL6, CD36, BMP4
2	craniofacial phenotype	MP:0005382	8.9	SLC26A2, NOTCH1, NOG, SP1, PTH1R, BMP4
3	hearing/vestibular/ear phenotype	MP:0005377	8.6	STRC, COL1A1, NOTCH1, NOG, TNFRSF11B, BMP4
4	embryogenesis phenotype	MP:0005380	8.4	NOTCH1, NOG, SP1, PTH1R, TJP2, ARFRP1
5	limbs/digits/tail phenotype	MP:0005371	8.3	SLC26A2, COL1A2, COL1A1, NOG, SP1, PTH1R
6	muscle phenotype	MP:0005369	7.9	TGFB1, AGT, COL1A2, COL1A1, NOTCH1, NOG
7	digestive/alimentary phenotype	MP:0005381	7.7	TGFB1, COL1A1, NOTCH1, NOG, PTH1R, IL6
8	skeleton phenotype	MP:0005390	7.4	BMP2, SLC26A2, COL1A2, NOTCH1, NOG, SP1
9	vision/eye phenotype	MP:0005391	7.3	TGFB1, COL1A1, NOTCH1, NOG, SP1, IL6
10	renal/urinary system phenotype	MP:0005367	7.2	TGFB1, AGTR1, AGT, ACE, NOTCH1, NOG
11	cellular phenotype	MP:0005384	6.1	NOTCH1, COL1A1, COL1A2, ACE, TGFB1, SLC26A2
12	cardiovascular system phenotype	MP:0005385	5.9	COL1A1, COL1A2, ACE, AGT, AGTR1, TGFB1
13	growth/size phenotype	MP:0005378	5.2	NOTCH1, COL1A1, COL1A2, ACE, AGT, AGTR1
14	mortality/aging	MP:0010768	4.6	NOTCH1, COL1A1, COL1A2, ACE, AGT, AGTR1

Articles related to otosclerosis:

(show all 37)

id	Title	Authors	Year	Affiliating Genes
1	Restriction analysis of otosclerosis-associated CD46 splicing variants. (19597833)	Csomor P.... Karosi T.	2010	CD46
2	Lack of association between SNP rs3914132 of the RELN gene and otosclerosis in India. (20882487)	Priyadarshi S.... Ramchander P.V.	2010	RELN
3	Involvement of T-cell receptor-beta alterations in th e development of otosclerosis linked to OTSC2. (20182450)	Schrauwen I.... Van Camp G.	2010	OTSC2
4	Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations. (19847460)	Schrauwen I.... Van Camp G.	2010	RELN
5	No evidence for association between the renin-angiote nsin-aldosterone system and otosclerosis in a large Belgian-Dutch population. (19503013)	Schrauwen I.... Van Camp G.	2009	ACE, AGTR1, AGT
6	Detection of rare nonsynonymous variants in TGFB1 in otosclerosis patients. (19207109)	Thys M.... Van Camp G.	2009	TGFB1
7	A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. (19230858)	Schrauwen I.... Van Camp G.	2009	RELN
8	Otosclerosis or congenital stapes ankylosis? The diag nostic role of genetic analysis. (19471170)	Emery S.B.... Lesperance M.M.	2009	NOG
9	Genetics of otosclerosis. (19546831)	Thys M.... Van Camp G.	2009	TGFB1
10	Otosclerosis and TGF-beta 1 gene in black South Africans. (19113055)	Tshifularo M.... Joseph C.A.	2008	TGFB1
11	Disease-associated novel CD46 splicing variants and pathologic bone remodeling in otosclerosis. (18677279)	Karosi T.... Sziklai I.	2008	CD46
12	A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9. (18224337)	Bel Hadj Ali I.... Van Camp G.	2008	TJP2, TRPM3, KLF9
13	Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study. (18491423)	Imauchi Y.... Grayeli A.B.	2008	ACE, AGTR1, AGT
14	Medical treatment of otosclerosis: rationale for use of bisphosphonates. (19205157)	Brookler K.	2008	TNFRSF11B
15	Association of bone morphogenetic proteins with otosclerosis. (18021008)	Schrauwen I.... Van Camp G.	2008	TGFB1, BMP4, BMP2
16	Phenotype description of a Dutch otosclerosis family with suggestive linkage to OTSC7. (17568406)	Pauw R.J.... Cremers C.W.	2007	OTSC7
17	The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. (17588962)	Thys M.... Van Camp G.	2007	TGFB1
18	Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosis. (17489845)	Chen W.... Smith R.J.	2007	COL1A1
19	A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13-16.1. (17213839)	Thys M.... Van Camp G.	2007	OTSC7
20	Clinical and genetic analysis of two Tunisian otosclerosis families. (17568407)	Ali I.B.... Camp G.V.	2007	COL1A2
21	Chromosomal mapping and phenotypic characterization of hereditary otosclerosis linked to the OTSC4 locus. (16618911)	Brownstein Z.... Avraham K.B.	2006	OTSC4
22	Monogenic nonsyndromic otosclerosis: audiological and linkage analysis in a large Greek pedigree. (16168495)	Iliadou V.... Petersen M.B.	2006	COL1A1, COL1A2, NOG
23	Glucocorticoids inhibit diastrophic dysplasia sulfate transporter activity in otosclerosis by interleukin-6. (16954997)	Imauchi Y.... Grayeli A.B.	2006	IL6, SLC26A2
24	The phenotype of the first otosclerosis family linked to OTSC5. (16639267)	Pauw R.J.... Cremers C.W.	2006	OTSC5
25	Current research in otosclerosis. (16974150)	Stankovic K.M.... McKenna M.J.	2006	TNFRSF11B
26	Association of otosclerosis with Sp1 binding site polymorphism in COL1A1 gene: evidence for a shared genetic etiology with osteoporosis. (15241219)	McKenna M.J.... Kristiansen A.G.	2004	COL1A1, SP1
27	Association between osteoporosis and otosclerosis in women. (15453937)	Clayton A.E.... McKenna M.J.	2004	COL1A1
28	Proposed association between the COL1A1 and COL1A2 genes and otosclerosis is not supported by a case-control study in Spain. (15211650)	Rodriguez L.... Zapata C.	2004	COL1A1, COL1A2
29	A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22-24. (15173231)	Van Den Bogaert K.... Van Camp G.	2004	OTSC5
30	Increased activity of the diastrophic dysplasia sulfate transporter in otosclerosis and its inhibition by sodium fluoride. (14600463)	Grayeli A.B.... Ferrary E.	2003	SLC26A2
31	Linkage of otosclerosis to a third locus (OTSC3) on human chromosome 6p21.3-22.3. (12114476)	Chen W.... Smith R.J.	2002	OTSC3
32	Similar COL1A1 expression in fibroblasts from some patients with clinical otosclerosis and those with type I osteogenesis imperfecta. (11860074)	McKenna M.J.... Tropitzsch A.S.	2002	COL1A1
33	A second gene for otosclerosis, OTSC2, maps to chromosome 7q34-36. (11170898)	Van Den Bogaert K.... Van Camp G.	2001	OTSC2
34	Parathyroid hormone-parathyroid hormone-related peptide receptor expression and function in otosclerosis. (10600788)	Grayeli A.B.... Silve C.	1999	PTH1R
35	Association of COL1A1 and otosclerosis: evidence for a shared genetic etiology with mild osteogenesis imperfecta. (9752968)	McKenna M.J.... Haines J.L.	1998	COL1A1, CD36
36	Localization of a gene for otosclerosis to chromosome 15q25-q26. (9425236)	Tomek M.S.... Smith R.J.	1998	OTSC1
37	Antibodies to the minor cartilage collagen type IX in otosclerosis. (8172305)	BujA-a J.... Burmester G.	1994	CD36

Genes related to otosclerosis according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	OTSC5	otosclerosis 5	11.1	Aliases & Descriptions, Publications
2	OTSC7	otosclerosis 7	11.1	Aliases & Descriptions, Publications
3	OTSC4	otosclerosis 4	11.0	Publications, Aliases & Descriptions
4	OTSC1	otosclerosis 1	11.0	Publications, Aliases & Descriptions
5	OTSC8	otosclerosis 8	11.0	Aliases & Descriptions, Publications
6	OTSC3	otosclerosis 3	11.0	Publications, Aliases & Descriptions
7	OTSC2	otosclerosis 2	11.0	Aliases & Descriptions, Publications
8	OTSC9	otosclerosis 9	11.0	Aliases & Descriptions
9	OTSC6	otosclerosis 6	11.0	Aliases & Descriptions
10	OTSC10	otosclerosis 10	11.0	Aliases & Descriptions
11	COL1A2	collagen, type I, alpha 2	11.0	Publications
12	NOG	noggin	11.0	Publications
13	SLC26A2	solute carrier family 26 (sulfate transporter), member 2	11.0	Publications
14	COL1A1	collagen, type I, alpha 1	11.0	Publications
15	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
16	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
17	TGFB1	transforming growth factor, beta 1	11.0	Publications
18	STRC	stereocilin	11.0
19	A1BG	alpha-1-B glycoprotein	11.0
20	ARFRP1	ADP-ribosylation factor related protein 1	11.0
21	KLF9	Kruppel-like factor 9	11.0	Publications
22	ARMC10	armadillo repeat containing 10	11.0
23	PTH1R	parathyroid hormone 1 receptor	11.0	Publications
24	BMP3	bone morphogenetic protein 3	11.0
25	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
26	BMP4	bone morphogenetic protein 4	11.0	Publications
27	TJP2	tight junction protein 2	11.0	Publications
28	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
29	RELN	reelin	11.0	Publications
30	NOTCH1	notch 1	11.0
31	AGTR1	angiotensin II receptor, type 1	11.0	Publications
32	BMP2	bone morphogenetic protein 2	11.0	Publications
33	TRPM3	transient receptor potential cation channel, subfamily M, member 3	11.0	Publications
34	SP1	Sp1 transcription factor	11.0	Publications
35	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
36	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to otosclerosis according to GeneDecks:

(show top 50)    (show all 57)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	AGTR1
2	Actin-Based Motility by Rho Family GTPases36	10.1	BMP4, BMP3
3	Inhibition of Angiogenesis by TSP136	10.1	TGFB1, COL1A2, COL1A1, CD36
4	ECM-receptor interaction20	10.0	COL1A2, COL1A1, CD36, RELN
5	Glioma Invasiveness36	9.9	BMP4, BMP3, BMP2
6	Telomerase Components in Cell Signaling36	9.9	BMP2, BMP3, BMP4
7	Cell adhesion_Integrin inside-out signaling41	9.8	COL1A1, COL1A2, AGT, AGTR1
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.8	IL6, TNFRSF11B, PTH1R, COL1A1
9	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.8	COL1A1, PTH1R, TNFRSF11B, IL6
10	eIF2 Pathway36	9.7	BMP3, BMP4, IL6
11	Factors Promoting Cardiogenesis in Vertebrates36	9.7	BMP2, NOG, TGFB1
12	Amoebiasis20	9.7	TGFB1, COL1A2, COL1A1, IL6
13	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.6	PTH1R, COL1A1, COL1A2
14	PTEN Pathway36	9.6	COL1A2, COL1A1, BMP4, BMP3, BMP2
15	Human Embryonic Stem Cell Pluripotency36	9.6	TGFB1, NOG, BMP4, BMP3, BMP2
16	NFAT Signaling and Lymphocyte Interactions36	9.5	BMP2, BMP3, BMP4
17	SMAD Signaling Network36	9.5	TGFB1, BMP4, BMP3, BMP2
18	Paxillin Interactions36	9.4	BMP4, BMP3, BMP2
19	Renin-angiotensin system20	9.3	AGTR1, AGT, ACE
20	TGF-beta signaling pathway20	9.2	TGFB1, NOG, SP1, BMP4, BMP2
21	Apoptotic Pathways in Synovial Fibroblasts36	9.2	TGFB1, IL6, BMP4, BMP3, BMP2
22	p53 Mediated Apoptosis36	9.2	BMP2, BMP3, BMP4, IL6, TGFB1
23	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.2	TGFB1, AGTR1, AGT, ACE
24	Mitochondrial Apoptosis36	9.2	TGFB1, IL6, BMP4, BMP3, BMP2
25	NF-KappaB (p50-p65) Pathway36	9.2	TGFB1, IL6, BMP4, BMP3, BMP2
26	DHA Signaling36	9.1	BMP2, BMP3, BMP4, IL6, TGFB1
27	Glucocorticoid Receptor Signaling36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
28	NF-KappaB Family Pathway36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
29	mTOR Pathway36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
30	ERK5 Signaling36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
31	Cellular Apoptosis Pathway36	9.1	BMP2, BMP3, BMP4, IL6, TGFB1
32	PPAR Pathway36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
33	Nanog in Mammalian ESC Pluripotency36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
34	Nuclear Receptor Activation by Vitamin-A36	9.1	TGFB1, IL6, BMP4, BMP3, BMP2
35	Rac1 Pathway36	9.0	TGFB1, IL6, BMP4, BMP3, BMP2
36	p70S6K Signaling36	8.9	BMP2, BMP3, BMP4, IL6, TGFB1
37	IP3 Pathway36	8.9	TGFB1, IL6, BMP4, BMP3, BMP2
38	Phospholipase-C Pathway36	8.9	TGFB1, COL1A2, COL1A1, IL6, BMP4, BMP3
39	ILK Signaling36	8.9	TGFB1, COL1A2, COL1A1, IL6, BMP4, BMP3
40	MAPK Signaling36	8.9	TGFB1, COL1A2, COL1A1, IL6, BMP4, BMP3
41	Rho Family GTPases36	8.8	TGFB1, COL1A2, COL1A1, IL6, BMP4, BMP3
42	Activation of PKC through GPCR36	8.8	TGFB1, IL6, BMP4, BMP3, BMP2
43	Pancreatic Adenocarcinoma36	8.8	TGFB1, NOTCH1, IL6, BMP4, BMP3, BMP2
44	Epithelial Adherens Junctions36	8.8	TGFB1, NOTCH1, IL6, BMP4, BMP3, BMP2
45	ERK Signaling36	8.7	TGFB1, COL1A2, COL1A1, IL6, BMP4, BMP3
46	Estrogen Pathway36	8.5	TGFB1, SP1, IL6, BMP4, BMP3, BMP2
47	Intracellular Calcium Signaling36	8.5	TGFB1, TRPM3, IL6, BMP4, BMP3, BMP2
48	Molecular Mechanisms of Cancer36	8.4	TGFB1, COL1A2, COL1A1, NOTCH1, IL6, BMP4
49	JAK-STAT Pathway36	7.9	TGFB1, AGTR1, AGT, SP1, IL6, BMP4
50	Renin-Angiotensin Pathway36	7.7	BMP2, TGFB1, AGTR1, AGT, ACE, IL6

Compounds related to otosclerosis according to GeneDecks:

(show top 50)    (show all 88)

id	Compound	Score	Top Affiliating Genes
1	teriparatide32 9 9	12.2	PTH1R, TNFRSF11B, CD36
2	titanium32	9.7	TNFRSF11B, CD36, BMP4, BMP2
3	hydroxyproline32 18	10.7	TGFB1, COL1A1, TNFRSF11B, CD36
4	pamidronate32 9 9	11.6	CD36, IL6, TNFRSF11B
5	procollagen32	9.6	TGFB1, COL1A2, COL1A1, TNFRSF11B, CD36, BMP2
6	captopril32 42 9 9	12.5	ACE, AGT
7	hydroxyapatite32	9.5	TNFRSF11B, CD46, CD36, BMP3, BMP2
8	zoledronic acid32	9.5	TNFRSF11B, IL6, CD36, BMP2
9	aliskiren32 9 9	11.3	AGTR1, AGT, ACE
10	matrigel32	9.3	BMP2, CD36, PTH1R, NOTCH1
11	saralasin32 42	10.2	ACE, AGT, AGTR1
12	ribonucleic acid32	9.2	TGFB1, COL1A2, COL1A1, NOG, PTH1R, BMP4
13	eprosartan32 9 9	11.2	AGTR1, AGT, ACE
14	pd12331932	9.2	AGTR1, AGT, ACE, CD36
15	benazepril32 9 9	11.2	TGFB1, AGTR1, AGT, ACE
16	olmesartan32 9 9	11.1	AGTR1, AGT, ACE
17	irbesartan32 9 9	11.1	AGTR1, AGT, ACE, TNFRSF11B
18	perindopril32 34 9 9	12.1	TGFB1, AGTR1, AGT, ACE
19	candesartan32 9 9	11.1	TGFB1, AGTR1, AGT, ACE
20	1,25 dihydroxy vitamin d332	9.0	TGFB1, COL1A1, SP1, PTH1R, TNFRSF11B, BMP2
21	tgf beta132	9.0	AGTR1, SP1, TNFRSF11B, IL6, CD36
22	deoxyribonucleic acid32	9.0	AGTR1, AGT, BMP4, BMP2
23	ang ii32	9.0	TGFB1, AGTR1, AGT, ACE, CD36
24	losartan32 34 9 9	11.9	TGFB1, AGTR1, AGT, ACE, CD36
25	azathioprine32 34 9 9	11.8	AGTR1, NOG, SP1, TNFRSF11B, BMP4, BMP2
26	cysteine32	8.7	SLC26A2, AGTR1, AGT, COL1A1, NOG, SP1
27	lisinopril32 9 18 9	11.6	ACE, AGT, AGTR1
28	ly29400232	8.6	TGFB1, AGT, COL1A2, NOTCH1, SP1, TNFRSF11B
29	nifedipine32 9 9	10.4	TGFB1, AGTR1, AGT, ACE, BMP2
30	calcitriol32 42 9 18 9	12.3	TGFB1, SP1, PTH1R, TNFRSF11B, IL6, CD36
31	simvastatin32 34 42 9 18 9	13.3	AGTR1, AGT, COL1A2, COL1A1, SP1, IL6
32	cyclosporin a32 42	9.2	TGFB1, AGTR1, AGT, TNFRSF11B, IL6, CD46
33	forskolin32 42 9 9	11.1	AGTR1, AGT, SP1, PTH1R, TNFRSF11B, BMP4
34	thymidine32 18	8.9	TGFB1, AGT, COL1A2, COL1A1, SP1, PTH1R
35	actinomycin d32	7.9	TGFB1, AGTR1, AGT, SP1, IL6, BMP4
36	vitamin d32	7.8	TGFB1, AGTR1, COL1A2, COL1A1, SP1, PTH1R
37	genistein32 9 18 9	10.8	AGTR1, AGT, NOTCH1, SP1, TNFRSF11B, IL6
38	sb 20358032 42	8.8	TGFB1, AGTR1, AGT, SP1, TNFRSF11B, IL6
39	pge232	7.8	TGFB1, AGT, COL1A1, SP1, PTH1R, TNFRSF11B
40	phosphatidylinositol32	7.7	AGTR1, AGT, COL1A2, NOTCH1, SP1, TNFRSF11B
41	creatinine32	7.7	TGFB1, AGTR1, AGT, ACE, TNFRSF11B, IL6
42	cycloheximide32	7.6	TGFB1, AGTR1, NOG, SP1, TNFRSF11B, IL6
43	retinoic acid32 42 18	9.5	TGFB1, COL1A1, NOTCH1, NOG, SP1, PTH1R
44	estrogen32	7.1	NOTCH1, COL1A1, COL1A2, AGTR1, TGFB1, SP1
45	vegf32	7.1	NOTCH1, COL1A1, AGT, AGTR1, TGFB1, NOG
46	nitric oxide32 9 18 9	9.9	AGTR1, AGT, ACE, NOTCH1, PTH1R, TNFRSF11B
47	serine32	6.6	NOTCH1, COL1A1, COL1A2, AGT, AGTR1, TGFB1
48	tyrosine32	6.3	AGTR1, AGT, COL1A2, NOTCH1, NOG, SP1
49	dexamethasone32 42 34 9 9	10.2	BMP2, SLC26A2, TGFB1, AGTR1, AGT, COL1A1
50	calcium32 9 18 9	8.5	NOG, NOTCH1, COL1A1, COL1A2, ACE, AGT

Cellular components related to otosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen type I	GO:005584	9.9	COL1A1, COL1A2
2	membrane-bounded vesicle	GO:031988	9.4	BMP4, BMP3, BMP2
3	extracellular region	GO:005576	7.5	TGFB1, AGT, COL1A2, COL1A1, NOTCH1, NOG
4	extracellular space	GO:005615	6.6	RELN, TGFB1, AGT, ACE, COL1A2, COL1A1

Biological processes related to otosclerosis according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	face morphogenesis	GO:060325	10.3	TGFB1, COL1A1, NOG
2	positive regulation of NAD(P)H oxidase activity	GO:033864	10.1	AGTR1, AGT
3	embryonic skeletal joint morphogenesis	GO:060272	10.1	NOG, BMP4
4	chondrocyte differentiation	GO:002062	10.1	TGFB1, PTH1R, BMP4
5	blood vessel development	GO:001568	10.1	COL1A1, COL1A2, AGT
6	mesenchymal cell proliferation involved in ureteric bud development	GO:072138	10.1	BMP4, BMP2
7	BMP signaling pathway involved in heart induction	GO:003130	10.0	BMP4, BMP2
8	regulation of blood vessel size by renin-angiotensin	GO:002034	10.0	AGTR1, AGT
9	negative regulation of myoblast differentiation	GO:045662	10.0	TGFB1, NOTCH1, BMP4
10	renin-angiotensin regulation of aldosterone production	GO:002018	10.0	AGTR1, AGT
11	positive regulation of cellular protein metabolic process	GO:032270	10.0	TGFB1, AGTR1, AGT
12	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.0	AGTR1, AGT, CD36
13	positive regulation of branching involved in ureteric bud morphogenesis	GO:090190	10.0	TGFB1, AGT, NOG, BMP4
14	regulation of renal sodium excretion	GO:035813	9.9	AGTR1, AGT
15	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.9	AGTR1, AGT, CD36
16	telencephalon regionalization	GO:021978	9.9	BMP4, BMP2
17	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.9	TGFB1, BMP4, BMP2
18	embryonic skeletal system development	GO:048706	9.9	COL1A1, NOG, SP1
19	mononuclear cell proliferation	GO:032943	9.8	TGFB1, ACE
20	positive regulation of bone mineralization	GO:030501	9.8	BMP2, BMP4, TGFB1
21	osteoblast differentiation	GO:001649	9.8	BMP2, BMP4, NOG, COL1A1
22	cellular response to growth factor stimulus	GO:071363	9.8	BMP2, BMP4, COL1A1, TGFB1
23	phospholipase C-activating G-protein coupled receptor signaling pathway	GO:007200	9.7	AGTR1, AGT, PTH1R
24	regulation of odontogenesis of dentin-containing tooth	GO:042487	9.7	BMP4, BMP2
25	positive regulation of odontogenesis	GO:042482	9.7	TGFB1, BMP2
26	epithelial to mesenchymal transition	GO:001837	9.7	TGFB1, NOTCH1, NOG, BMP2
27	positive regulation of epithelial to mesenchymal transition	GO:010718	9.7	BMP2, NOTCH1, COL1A1, TGFB1
28	regulation of renal output by angiotensin	GO:002019	9.7	AGT, ACE
29	response to corticosteroid stimulus	GO:031960	9.6	COL1A1, NOTCH1
30	negative regulation of cell cycle	GO:045786	9.6	BMP2, BMP4, TGFB1
31	platelet activation	GO:030168	9.5	TGFB1, COL1A2, COL1A1, IL6, CD36
32	branching involved in ureteric bud morphogenesis	GO:001658	9.5	AGT, BMP4, BMP2
33	positive regulation of cell migration	GO:030335	9.5	BMP2, NOTCH1, COL1A1, TGFB1
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	AGT, IL6, CD36, RELN
35	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	9.4	AGTR1, ACE
36	regulation of vasoconstriction	GO:019229	9.3	AGTR1, AGT, ACE
37	skeletal system development	GO:001501	9.3	BMP2, BMP3, TNFRSF11B, PTH1R, NOG, COL1A1
38	kidney development	GO:001822	9.0	BMP4, ACE, AGT, AGTR1
39	negative regulation of cell proliferation	GO:008285	8.8	TGFB1, AGT, PTH1R, IL6, BMP4, BMP2
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	TGFB1, NOTCH1, NOG, SP1, IL6, BMP4
41	positive regulation of transcription, DNA-dependent	GO:045893	8.0	TGFB1, AGT, COL1A1, NOTCH1, SP1, IL6

Molecular functions related to otosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	BMP receptor binding	GO:070700	9.5	BMP2, BMP3, BMP4
2	acetyltransferase activator activity	GO:010698	9.4	AGT, AGTR1
3	bradykinin receptor binding	GO:031711	9.2	ACE, AGTR1
4	cytokine activity	GO:005125	8.7	TNFRSF11B, IL6, BMP4, BMP3, BMP2
5	growth factor activity	GO:008083	8.5	TGFB1, AGT, IL6, BMP4, BMP3, BMP2