MCID: OTS001
MIFTS: 35

Otosclerosis

Categories: Ear diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Otosclerosis

MalaCards integrated aliases for Otosclerosis:

Name: Otosclerosis 12 24 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12185
ICD9CM 35 387.8
SNOMED-CT 64 194382008 194691004
UMLS 69 C0029696

Summaries for Otosclerosis

Disease Ontology : 12 An otitis interna characterized by an abnormal bone growth in the middle ear.

MalaCards based summary : Otosclerosis is related to otosclerosis 1 and otosclerosis 10, and has symptoms including earache An important gene associated with Otosclerosis is COL1A1 (Collagen Type I Alpha 1 Chain). The drugs Acetylcysteine and Antidotes have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells.

Wikipedia : 72 Otosclerosis or otospongiosis is an abnormal growth of bone near the middle ear. It can result in... more...

Related Diseases for Otosclerosis

Graphical network of the top 20 diseases related to Otosclerosis:



Diseases related to Otosclerosis

Symptoms & Phenotypes for Otosclerosis

UMLS symptoms related to Otosclerosis:


earache

Drugs & Therapeutics for Otosclerosis

Drugs for Otosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2 Antidotes Phase 4
3 Anti-Infective Agents Phase 4
4 Antioxidants Phase 4
5 Antiviral Agents Phase 4
6 Expectorants Phase 4
7 N-monoacetylcystine Phase 4
8 Protective Agents Phase 4
9 Respiratory System Agents Phase 4
10
tiludronate Approved, Vet_approved Phase 3 89987-06-4 60937
11 Bone Density Conservation Agents Phase 3
12 Diphosphonates Phase 3

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis Completed NCT00525551 Phase 4 Acetylcysteine;Placebo (NaCl)
2 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417 Phase 2, Phase 3
3 Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot Study Recruiting NCT02456272 Phase 3
4 Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced Otosclerosis Terminated NCT01617057 Phase 3 tiludronic acid;Placebo
5 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
6 Quantification of Prosthesis Penetration With Conebeam in Otosclerosis Completed NCT02901093
7 Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively Completed NCT02554422
8 Clinical Assessment of the External Sound Processor Worn by Patients Implanted With Codacs Completed NCT02156167
9 Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
10 Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS) Recruiting NCT02435446
11 Wide Frequency Band Test of Hearing in Veterans Enrolling by invitation NCT02019888

Search NIH Clinical Center for Otosclerosis

Genetic Tests for Otosclerosis

Genetic tests related to Otosclerosis:

id Genetic test Affiliating Genes
1 Otosclerosis 29 24

Anatomical Context for Otosclerosis

MalaCards organs/tissues related to Otosclerosis:

39
Bone, Testes, T Cells, Cortex, Eye

Publications for Otosclerosis

Articles related to Otosclerosis:

(show top 50) (show all 582)
id Title Authors Year
1
An Assessment of the Clinical Acceptability of Direct Acoustic Cochlear Implantation for Adults With Advanced Otosclerosis in the United Kingdom. ( 28538469 )
2017
2
Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth? ( 27851656 )
2017
3
Cochlear Implantation in Otosclerosis: Surgical and Auditory Outcomes With a Brief on Facial Nerve Stimulation. ( 28902803 )
2017
4
Diagnostic performance of high resolution computed tomography in otosclerosis. ( 28798924 )
2017
5
Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis. ( 28090791 )
2017
6
Otosclerosis: An update on diagnosis and treatment. ( 28060022 )
2017
7
Cochlear implantation in patients with otosclerosis of the otic capsule. ( 28549773 )
2017
8
Audiological outcome of stapes surgery for far advanced cochlear otosclerosis. ( 28874211 )
2017
9
Importance of a dedicated neuroradiologist in reporting high-resolution computed tomography for otosclerosis: a retrospective comparison study of 40 patients. ( 28318477 )
2017
10
Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome. ( 28068300 )
2017
11
Diagnosis of Superior Semicircular Canal Dehiscence in the Presence of Concomitant Otosclerosis. ( 28657952 )
2017
12
The surgical treatment results of otosclerosis at the Department of Otolaryngology Silesian Medical University in Zabrze in years 2000-2010. ( 28485298 )
2017
13
Relation of otosclerosis and osteoporosis: A bone mineral density study. ( 26656733 )
2016
14
Update on the imaging diagnosis of otosclerosis. ( 27267384 )
2016
15
Long-term Incidence and Degree of Sensorineural Hearing Loss in Otosclerosis. ( 27755362 )
2016
16
Evaluation of Functional Outcomes after Stapes Surgery in Patients with Clinical Otosclerosis in a Teaching Institution. ( 26722344 )
2016
17
Diode Laser Stapedotomy vs Conventional Stapedotomy in Otosclerosis: A Double-Blinded Randomized Clinical Trial. ( 26980905 )
2016
18
Otosclerosis Associated with a De Novo Mutation -832Ga88>a88A in the TGFB1 Gene Promoter Causing a Decreased Expression Level. ( 27404893 )
2016
19
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients. ( 26804928 )
2016
20
Obliquity of the Stapes in Otosclerosis: A New Radiological Sign. ( 27096011 )
2016
21
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. ( 27383734 )
2016
22
Endoscopic approach for cochlear implantation in advanced otosclerosis: A case report. ( 27106776 )
2016
23
Does stapes surgery improve tinnitus in patients with otosclerosis? ( 27553985 )
2016
24
Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis. ( 27676652 )
2016
25
Oxidative stress in otosclerosis. ( 27387094 )
2016
26
The Effect of Piston Diameter in Stapedotomy for Otosclerosis: A Temporal Bone Model. ( 27642666 )
2016
27
How Often Does Stapedectomy for Otosclerosis Result in Endolymphatic Hydrops? ( 27380537 )
2016
28
Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling. ( 27034709 )
2016
29
Flexible Fiber Optic Carbon-Dioxide Laser Assisted Stapedotomy in Otosclerosis. ( 27725835 )
2016
30
Analysis of hearing improvement in the patients operated on due to otosclerosis in the Otolaryngology Department of Jagiellonian University of Cracow, Poland. ( 27386930 )
2016
31
A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis. ( 26649602 )
2016
32
Juvenile otosclerosis: a case presentation and review of the literature. ( 27084899 )
2016
33
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial. ( 26924941 )
2016
34
3D-Flair sequence at 3T in cochlear otosclerosis. ( 26747254 )
2016
35
Diagnostic efficacy and therapeutic impact of computed tomography in the evaluation of clinically suspected otosclerosis. ( 27364152 )
2016
36
Vestibular Disorders after Stapedial Surgery in Patients with Otosclerosis. ( 26904127 )
2016
37
Mutations and altered expression of SERPINF1 in patients with familial otosclerosis. ( 27056980 )
2016
38
Stapedotomy vs Cochlear Implantation for Advanced Otosclerosis: Systematic Review and Meta-analysis. ( 27329418 )
2016
39
Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. ( 26841857 )
2016
40
Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis? ( 26571406 )
2015
41
Book review: review of otosclerosis diagnosis, evaluation, pathology, surgical techniques, and outcomes. ( 25670834 )
2015
42
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery. ( 26567711 )
2015
43
A systematic review of the effect of different crimping techniques in stapes surgery for otosclerosis. ( 26333166 )
2015
44
A systematic review of the effect of piston diameter in stapes surgery for otosclerosis on hearing results. ( 26108164 )
2015
45
Otosclerosis Without Stapes Fixation. ( 25839982 )
2015
46
Primary stapedotomy in children with otosclerosis: A prospective study of 41 consecutive cases. ( 26016603 )
2015
47
Factors affecting postoperative outcome in otosclerosis patients: Predictive role of audiological and clinical features. ( 25857423 )
2015
48
Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study. ( 26309142 )
2015
49
Genetic association and altered gene expression of osteoprotegerin in otosclerosis patients. ( 25998045 )
2015
50
Otosclerosis and Fitness to Fly. ( 26630051 )
2015

Variations for Otosclerosis

Expression for Otosclerosis

Search GEO for disease gene expression data for Otosclerosis.

Pathways for Otosclerosis

GO Terms for Otosclerosis

Sources for Otosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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