MCID: OVR010
MIFTS: 32

Ovarian Brenner Tumor malady

Cancer category

Summaries for Ovarian Brenner Tumor

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  brenner tumors of the ovary usually do not cause symptoms.  approximately 2% of all ovarian tumors are brenner tumors.  there are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.  the current preferred term for benign brenner tumors of the ovary is transitional cell tumors.  these tumors usually occur in women ages 40 to 60 years.  treatment usually consists of surgery to remove the tumor.  if a brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis. last updated: 1/11/2012

MalaCards: Ovarian Brenner Tumor, also known as brenner tumor, is related to transitional cell carcinoma and cystadenoma. An important gene associated with Ovarian Brenner Tumor is UPK3A (uroplakin 3A). The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and cervix.

Wikipedia:64 Brenner tumors are uncommon tumours that are part of the surface epithelial-stromal tumor group of... more...

Aliases & Classifications for Ovarian Brenner Tumor

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

ovarian brenner tumor 8 43 10
brenner tumor 8 45 61
brenner tumor of ovary 8 43
brenner tumor nos 8
brenner tumors 8


External Ids:

Disease Ontology8 DOID:2636
MeSH35 D001948

Related Diseases for Ovarian Brenner Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Ovarian Brenner Tumor family:

malignant ovarian brenner tumor

Diseases related to Ovarian Brenner Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.5UPK1B, UPK2
2cystadenoma30.1KRT7
3bladder carcinoma30.1UPK2, UPK3A, UPK1A, KRT20
4malignant ovarian brenner tumor10.6
5struma ovarii10.5
6ovary transitional cell carcinoma10.4
7testicular brenner tumor10.3
8brenner tumor of the vagina10.3
9teratoma10.3
10meigs syndrome10.3
11adenocarcinoma10.2
12ovarian squamous cell carcinoma10.2
13endometrial stromal sarcoma10.2
14squamous cell carcinoma10.2
15uterine fibroid10.2
16mucinous ovarian cystadenoma10.1
17gonadoblastoma10.1
18systemic lupus erythematosus10.1
19benign struma ovarii10.1
20hypercalcemia10.1
21breast lymphoma10.1
22bilateral breast cancer10.1
23bladder transitional cell carcinoma10.1
24breast adenocarcinoma10.1
25inverted papilloma10.0KRT20
26cystitis10.0UPK1A, UPK2
27mixed cell type cancer10.0KRT7
28renal oncocytoma10.0KRT7
29nephrogenic adenoma10.0UPK3A, KRT7
30bladder carcinoma in situ10.0UPK3A, KRT20, UPK2
31bladder adenocarcinoma10.0KRT7, KRT20
32mammary paget's disease10.0KRT20, KRT7
33signet ring cell adenocarcinoma10.0KRT7, KRT20
34mucinous cystadenocarcinoma10.0KRT20, KRT7
35cutaneous paget's disease10.0KRT20, KRT7
36pancreatic ductal carcinoma10.0KRT20, KRT7
37pseudomyxoma peritonei10.0KRT20, KRT7
38bronchiolo-alveolar adenocarcinoma10.0KRT20, KRT7
39tubular adenocarcinoma10.0KRT7, KRT20
40chordoma10.0KRT7
41malignant mesothelioma10.0KRT20, KRT7
42abrikosov's tumor10.0KRT7, KRT20
43adenosquamous carcinoma10.0KRT20, KRT7
44large cell carcinoma10.0KRT7, KRT20
45endometrial carcinoma10.0KRT7, KRT20
46adenoid cystic carcinoma10.0KRT20, KRT7
47oxyphilic adenoma10.0KRT7, KRT20
48neuroendocrine carcinoma10.0KRT7, KRT20
49barrett's esophagus10.0KRT20, KRT7
50benign mesothelioma10.0KRT20, KRT7

Graphical network of the top 20 diseases related to Ovarian Brenner Tumor:



Diseases related to ovarian brenner tumor

Clinical Features for Ovarian Brenner Tumor

Drugs & Therapeutics for Ovarian Brenner Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ovarian Brenner Tumor

Anatomical Context for Ovarian Brenner Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Ovarian Brenner Tumor:

33
Ovary, Cervix

Animal Models for Ovarian Brenner Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Ovarian Brenner Tumor

Sources:
51PubMed
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Articles related to Ovarian Brenner Tumor:

(show all 15)
idTitleAuthorsYear
1
Ovarian mucinous cystadenoma coexisting with benign Brenner tumor: MR imaging findings. (22476372)
2013
2
FDG PET/CT of a benign ovarian Brenner tumor. (22920385)
2012
3
Ovarian cystic tumor composed of Brenner tumor and struma ovarii. (22558485)
2012
4
A borderline ovarian Brenner tumor mimicks uterine fibroids. (21482385)
2011
5
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. (17581415)
2007
6
Left ovarian Brenner tumor. (16302335)
2005
7
Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. (11230712)
2001
8
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. (11520371)
2001
9
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (10514386)
1999
10
Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with Gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. (9067723)
1997
11
Squamous cell carcinoma of the cervix metastatic to an ovarian Brenner tumor. (7617659)
1995
12
A case of ovarian Brenner tumor with stromal estrogenic activity. (8092962)
1994
13
The histologic features and histogenesis of malignant ovarian Brenner tumor. (3100186)
1986
14
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
15
The ovarian Brenner tumor; its gross and microscopic pathology. (14789894)
1950

Genetic Variations for Ovarian Brenner Tumor

Expression for genes affiliated with Ovarian Brenner Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Brenner Tumor

Search GEO for disease gene expression data for Ovarian Brenner Tumor.

Pathways for genes affiliated with Ovarian Brenner Tumor

Compounds for genes affiliated with Ovarian Brenner Tumor

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank
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Compounds related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine459.1KRT20, KRT7
2hematoxylin459.1KRT20, KRT7
3b 723459.0KRT7, KRT20
4streptavidin458.8KRT20, KRT7
5troglitazone45 29 60 1111.6KRT20, UPK2, UPK1B

GO Terms for genes affiliated with Ovarian Brenner Tumor

Sources:
16Gene Ontology
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Cellular components related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1KRT20, KRT7
2apical plasma membraneGO:0163248.2UPK3A, UPK2, UPK1A, UPK1B

Biological processes related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:0308558.5UPK3A, UPK2, UPK1A, UPK1B

Products for genes affiliated with Ovarian Brenner Tumor

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Sources for Ovarian Brenner Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet