MCID: OVR010
MIFTS: 39

Ovarian Brenner Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Ovarian Brenner Tumor

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  brenner tumors of the ovary usually do not cause symptoms.  approximately 2% of all ovarian tumors are brenner tumors.  there are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.  the current preferred term for benign brenner tumors of the ovary is transitional cell tumors.  these tumors usually occur in women ages 40 to 60 years.  treatment usually consists of surgery to remove the tumor.  if a brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis. last updated: 1/11/2012

MalaCards: Ovarian Brenner Tumor, also known as brenner tumor, is related to transitional cell carcinoma and adenocarcinoma. An important gene associated with Ovarian Brenner Tumor is UPK3A (uroplakin 3A). The compounds mannose and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include ovary and cervix, and related mouse phenotype renal/urinary system.

Wikipedia:65 Brenner tumors are uncommon tumours that are part of the surface epithelial-stromal tumor group of... more...

Aliases & Classifications for Ovarian Brenner Tumor

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian brenner tumor 8 43 10
brenner tumor 8 45 62
brenner tumor of ovary 8 43
brenner tumor nos 8
brenner tumors 8


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Disease Ontology8 DOID:2636
MeSH35 D001948

Related Diseases for Ovarian Brenner Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Ovarian Brenner Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.6UPK2, UPK1B
2adenocarcinoma30.3UPK3A, KRT7, KRT20
3malignant ovarian brenner tumor10.5
4struma ovarii10.5
5testicular brenner tumor10.3
6cystic teratoma10.3
7brenner tumor of the vagina10.3
8teratoma10.3
9meigs syndrome10.3
10breast cancer10.2
11peritonitis10.2
12endometrial stromal sarcoma10.2
13leiomyomatosis10.2
14sarcoma10.2
15uterine fibroid10.2
16cystadenoma10.1
17hypercalcemia10.1
18gonadoblastoma10.1
19breast lymphoma10.1
20systemic lupus erythematosus10.1
21breast adenocarcinoma10.1
22endometrial adenocarcinoma10.1
23gonadal dysgenesis10.1
24lupus erythematosus10.1
25nephrogenic adenoma10.1UPK3A, KRT7
26cystitis10.0UPK2, UPK1A
27bladder carcinoma10.0KRT20, UPK3A
28bladder adenocarcinoma10.0KRT20, KRT7
29mammary paget's disease10.0KRT7, KRT20
30signet ring cell adenocarcinoma10.0KRT20, KRT7
31mucinous cystadenocarcinoma10.0KRT20, KRT7
32cutaneous paget's disease10.0KRT20, KRT7
33pancreatic ductal carcinoma10.0KRT20, KRT7
34pseudomyxoma peritonei10.0KRT20, KRT7
35bronchiolo-alveolar adenocarcinoma10.0KRT7, KRT20
36cervical adenocarcinoma10.0KRT20, KRT7
37tubular adenocarcinoma10.0KRT20, KRT7
38abrikosov's tumor10.0KRT7, KRT20
39adenosquamous carcinoma10.0KRT7, KRT20
40large cell carcinoma10.0KRT20, KRT7
41adenoid cystic carcinoma10.0KRT7, KRT20
42neuroendocrine carcinoma10.0KRT7, KRT20
43oxyphilic adenoma10.0KRT7, KRT20
44barrett's esophagus10.0KRT20, KRT7
45malignant mesothelioma10.0KRT7, KRT20
46benign mesothelioma10.0KRT20, KRT7
47papillary carcinoma10.0KRT20, KRT7
48cholangiocarcinoma10.0KRT7, KRT20
49basal cell carcinoma10.0KRT20, KRT7
50gastric adenocarcinoma10.0KRT20, KRT7

Graphical network of the top 20 diseases related to Ovarian Brenner Tumor:



Diseases related to ovarian brenner tumor

Symptoms for Ovarian Brenner Tumor

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Drugs & Therapeutics for Ovarian Brenner Tumor

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Ovarian Brenner Tumor

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Anatomical Context for Ovarian Brenner Tumor

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33MalaCards
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MalaCards organs/tissues related to Ovarian Brenner Tumor:

33
Ovary, Cervix

Animal Models for Ovarian Brenner Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ovarian Brenner Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0KRT7, UPK2, UPK3A

Publications for Ovarian Brenner Tumor

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52PubMed
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Articles related to Ovarian Brenner Tumor:

(show all 12)
idTitleAuthorsYear
1
FDG PET/CT of a benign ovarian Brenner tumor. (22920385)
2012
2
A borderline ovarian Brenner tumor mimicks uterine fibroids. (21482385)
2011
3
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. (17581415)
2007
4
Left ovarian Brenner tumor. (16302335)
2005
5
Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. (11230712)
2001
6
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. (11520371)
2001
7
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (10514386)
1999
8
Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with Gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. (9067723)
1997
9
Squamous cell carcinoma of the cervix metastatic to an ovarian Brenner tumor. (7617659)
1995
10
A case of ovarian Brenner tumor with stromal estrogenic activity. (8092962)
1994
11
The histologic features and histogenesis of malignant ovarian Brenner tumor. (3100186)
1986
12
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973

Variations for Ovarian Brenner Tumor

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Expression for genes affiliated with Ovarian Brenner Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Brenner Tumor

Search GEO for disease gene expression data for Ovarian Brenner Tumor.

Pathways for genes affiliated with Ovarian Brenner Tumor

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Compounds for genes affiliated with Ovarian Brenner Tumor

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45Novoseek, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 11DrugBank
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Compounds related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannose459.5KRT7, UPK1A
2mucicarmine459.2KRT20, KRT7
3b 723459.2KRT20, KRT7
4streptavidin459.1KRT7, KRT20
5hematoxylin459.0KRT20, KRT7
6formaldehyde45 249.8KRT20, KRT7
7troglitazone45 29 61 1111.7KRT20, UPK2, UPK1B

GO Terms for genes affiliated with Ovarian Brenner Tumor

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16Gene Ontology
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Cellular components related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1KRT7, KRT20
2apical plasma membraneGO:0163248.4UPK1B, UPK2, UPK3A, UPK1A
3extracellular vesicular exosomeGO:0700628.2UPK1A, UPK3A, UPK2, UPK1B

Biological processes related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:0308558.5UPK2, UPK3A, UPK1A, UPK1B

Molecular functions related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.3KRT7, UPK1B

Products for genes affiliated with Ovarian Brenner Tumor

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Sources for Ovarian Brenner Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet