MCID: OVR010
MIFTS: 39

Ovarian Brenner Tumor malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Ovarian Brenner Tumor

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 A brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  brenner tumors of the ovary usually do not cause symptoms.  approximately 2% of all ovarian tumors are brenner tumors.  there are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.  the current preferred term for benign brenner tumors of the ovary is transitional cell tumors.  these tumors usually occur in women ages 40 to 60 years.  treatment usually consists of surgery to remove the tumor.  if a brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis. last updated: 1/11/2012

MalaCards based summary: Ovarian Brenner Tumor, also known as brenner tumor of ovary, is related to transitional cell carcinoma and adenocarcinoma. An important gene associated with Ovarian Brenner Tumor is UPK3A (uroplakin 3A). The compounds mannose and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include ovary and cervix, and related mouse phenotype renal/urinary system.

Wikipedia:65 Brenner tumors are uncommon tumours that are part of the surface epithelial-stromal tumor group of... more...

Aliases & Classifications for Ovarian Brenner Tumor

About this section

Ovarian Brenner Tumor, Aliases & Descriptions:

Name: Ovarian Brenner Tumor 8 42 10 62
Brenner Tumor of Ovary 8 42 62
Brenner Tumor 8 44 62
 
Brenner Tumors 8 62
Brenner Tumor Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:2636
MeSH34 D001948

Related Diseases for Ovarian Brenner Tumor

About this section

Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Ovarian Brenner Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.8UPK2, UPK1B
2adenocarcinoma30.1UPK3A, KRT7, KRT20
3malignant ovarian brenner tumor10.6
4struma ovarii10.5
5testicular brenner tumor10.3
6cystic teratoma10.3
7brenner tumor of the vagina10.3
8teratoma10.3
9breast cancer10.3
10peritonitis10.3
11endometrial stromal sarcoma10.3
12leiomyomatosis10.3
13sarcoma10.3
14uterine fibroid10.3
15nephrogenic adenoma10.2UPK3A, KRT7
16cystitis10.2UPK2, UPK1A
17systemic lupus erythematosus10.1
18cystadenoma10.1
19breast lymphoma10.1
20hypercalcemia10.1
21brooke-spiegler syndrome10.1
22gonadoblastoma10.1
23breast adenocarcinoma10.1
24endometrial adenocarcinoma10.1
25gonadal dysgenesis10.1
26lupus erythematosus10.1
27papillary adenocarcinoma10.1
28bladder carcinoma10.1KRT20, UPK3A
29bladder adenocarcinoma10.1KRT20, KRT7
30mammary paget's disease10.1KRT7, KRT20
31signet ring cell adenocarcinoma10.1KRT20, KRT7
32mucinous cystadenocarcinoma10.0KRT20, KRT7
33cutaneous paget's disease10.0KRT20, KRT7
34pancreatic ductal carcinoma10.0KRT20, KRT7
35pseudomyxoma peritonei10.0KRT20, KRT7
36bronchiolo-alveolar adenocarcinoma10.0KRT7, KRT20
37cervical adenocarcinoma10.0KRT20, KRT7
38tubular adenocarcinoma10.0KRT20, KRT7
39abrikosov's tumor10.0KRT7, KRT20
40adenosquamous carcinoma10.0KRT7, KRT20
41large cell carcinoma10.0KRT20, KRT7
42salivary gland adenoid cystic carcinoma10.0KRT7, KRT20
43neuroendocrine carcinoma10.0KRT7, KRT20
44oxyphilic adenoma10.0KRT7, KRT20
45barrett's esophagus10.0KRT20, KRT7
46malignant mesothelioma10.0KRT20, KRT7
47papillary carcinoma10.0KRT20, KRT7
48cholangiocarcinoma10.0KRT7, KRT20
49basal cell carcinoma10.0KRT20, KRT7
50gastric adenocarcinoma9.9KRT20, KRT7

Graphical network of the top 20 diseases related to Ovarian Brenner Tumor:



Diseases related to ovarian brenner tumor

Symptoms for Ovarian Brenner Tumor

About this section

Drugs & Therapeutics for Ovarian Brenner Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Ovarian Brenner Tumor

Search NIH Clinical Center for Ovarian Brenner Tumor

Genetic Tests for Ovarian Brenner Tumor

About this section

Anatomical Context for Ovarian Brenner Tumor

About this section

MalaCards organs/tissues related to Ovarian Brenner Tumor:

32
Ovary, Cervix

Animal Models for Ovarian Brenner Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Ovarian Brenner Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0KRT7, UPK2, UPK3A

Publications for Ovarian Brenner Tumor

About this section

Articles related to Ovarian Brenner Tumor:

(show all 13)
idTitleAuthorsYear
1
FDG PET/CT of a benign ovarian Brenner tumor. (22920385)
2012
2
A borderline ovarian Brenner tumor mimicks uterine fibroids. (21482385)
2011
3
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. (17581415)
2007
4
Left ovarian Brenner tumor. (16302335)
2005
5
Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. (11230712)
2001
6
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. (11520371)
2001
7
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (10514386)
1999
8
Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with Gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. (9067723)
1997
9
Squamous cell carcinoma of the cervix metastatic to an ovarian Brenner tumor. (7617659)
1995
10
A case of ovarian Brenner tumor with stromal estrogenic activity. (8092962)
1994
11
The histologic features and histogenesis of malignant ovarian Brenner tumor. (3100186)
1986
12
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
13
The ovarian Brenner tumor; its gross and microscopic pathology. (14789894)
1950

Variations for Ovarian Brenner Tumor

About this section

Expression for genes affiliated with Ovarian Brenner Tumor

About this section
Expression patterns in normal tissues for genes affiliated with Ovarian Brenner Tumor

Search GEO for disease gene expression data for Ovarian Brenner Tumor.

Pathways for genes affiliated with Ovarian Brenner Tumor

About this section

Compounds for genes affiliated with Ovarian Brenner Tumor

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR, 61Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannose449.5KRT7, UPK1A
2mucicarmine449.2KRT20, KRT7
3b 723449.2KRT20, KRT7
4streptavidin449.1KRT7, KRT20
5hematoxylin449.0KRT20, KRT7
6formaldehyde44 249.8KRT20, KRT7
7troglitazone44 28 61 1111.7KRT20, UPK2, UPK1B

GO Terms for genes affiliated with Ovarian Brenner Tumor

About this section

Cellular components related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1KRT20, KRT7
2apical plasma membraneGO:0163248.4UPK2, UPK3A, UPK1A, UPK1B
3extracellular vesicular exosomeGO:0700628.2UPK1B, UPK1A, UPK3A, UPK2

Biological processes related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:0308558.5UPK2, UPK3A, UPK1A, UPK1B

Molecular functions related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.3KRT7, UPK1B

Products for genes affiliated with Ovarian Brenner Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Ovarian Brenner Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet