MCID: OVR010
MIFTS: 35

Ovarian Brenner Tumor malady

Cancer diseases category

Summaries for Ovarian Brenner Tumor

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 A brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  brenner tumors of the ovary usually do not cause symptoms.  approximately 2% of all ovarian tumors are brenner tumors.  there are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.  the current preferred term for benign brenner tumors of the ovary is transitional cell tumors.  these tumors usually occur in women ages 40 to 60 years.  treatment usually consists of surgery to remove the tumor.  if a brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis. last updated: 1/11/2012

MalaCards: Ovarian Brenner Tumor, also known as brenner tumor, is related to transitional cell carcinoma and cystadenoma. An important gene associated with Ovarian Brenner Tumor is UPK3A (uroplakin 3A). The compounds mucicarmine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and cervix.

Wikipedia:63 Brenner tumors are uncommon tumours that are part of the surface epithelial-stromal tumor group of... more...

Aliases & Classifications for Ovarian Brenner Tumor

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian brenner tumor 8 42 10
brenner tumor 8 44 60
brenner tumor of ovary 8 42
brenner tumor nos 8
brenner tumors 8


External Ids:

Disease Ontology8 DOID:2636
MeSH34 D001948

Related Diseases for Ovarian Brenner Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Ovarian Brenner Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.5UPK2, UPK1B
2cystadenoma30.0KRT7
3bladder carcinoma30.0UPK3A, UPK2, UPK1A, KRT20
4malignant ovarian brenner tumor10.5
5struma ovarii10.5
6ovary transitional cell carcinoma10.3
7testicular brenner tumor10.3
8cystic teratoma10.3
9mature teratoma10.3
10brenner tumor of the vagina10.3
11ovarian squamous cell carcinoma10.2
12endometrial stromal sarcoma10.2
13endometrial stromal tumor10.2
14leiomyomatosis10.2
15sarcoma10.2
16squamous cell carcinoma10.2
17uterine fibroid10.2
18adenocarcinoma10.2
19breast cancer10.2
20peritonitis10.2
21mucinous ovarian cystadenoma10.0
22gonadoblastoma10.0
23systemic lupus erythematosus10.0
24benign struma ovarii10.0
25hypercalcemia10.0
26breast lymphoma10.0
27bilateral breast cancer10.0
28bladder transitional cell carcinoma10.0
29breast adenocarcinoma10.0
30endometrial adenocarcinoma10.0
31gonadal dysgenesis10.0
32lupus erythematosus10.0
33malignant teratoma10.0
34mature teratoma of the ovary10.0
35ovarian cystadenoma10.0
36inverted papilloma10.0KRT20
37cystitis10.0UPK1A, UPK2
38mixed cell type cancer10.0KRT7
39renal oncocytoma10.0KRT7
40nephrogenic adenoma10.0KRT7, UPK3A
41bladder carcinoma in situ10.0UPK3A, UPK2, KRT20
42bladder adenocarcinoma10.0KRT7, KRT20
43mammary paget's disease10.0KRT20, KRT7
44signet ring cell adenocarcinoma10.0KRT7, KRT20
45mucinous cystadenocarcinoma10.0KRT7, KRT20
46cutaneous paget's disease10.0KRT7, KRT20
47pancreatic ductal carcinoma10.0KRT20, KRT7
48pseudomyxoma peritonei10.0KRT20, KRT7
49bronchiolo-alveolar adenocarcinoma10.0KRT7, KRT20
50tubular adenocarcinoma10.0KRT7, KRT20

Graphical network of the top 20 diseases related to Ovarian Brenner Tumor:



Diseases related to ovarian brenner tumor

Clinical Features for Ovarian Brenner Tumor

About this section

Drugs & Therapeutics for Ovarian Brenner Tumor

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ovarian Brenner Tumor

Drug clinical trials:

Search ClinicalTrials for Ovarian Brenner Tumor

Search NIH Clinical Center for Ovarian Brenner Tumor

Search CenterWatch for Ovarian Brenner Tumor

Genetic Tests for Ovarian Brenner Tumor

About this section

Anatomical Context for Ovarian Brenner Tumor

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Ovarian Brenner Tumor:

32
Ovary, Cervix

Animal Models for Ovarian Brenner Tumor or affiliated genes

About this section

Publications for Ovarian Brenner Tumor

About this section
Sources:
50PubMed
See all sources

Articles related to Ovarian Brenner Tumor:

(show all 15)
idTitleAuthorsYear
1
Ovarian mucinous cystadenoma coexisting with benign Brenner tumor: MR imaging findings. (22476372)
2013
2
FDG PET/CT of a benign ovarian Brenner tumor. (22920385)
2012
3
Ovarian cystic tumor composed of Brenner tumor and struma ovarii. (22558485)
2012
4
A borderline ovarian Brenner tumor mimicks uterine fibroids. (21482385)
2011
5
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. (17581415)
2007
6
Left ovarian Brenner tumor. (16302335)
2005
7
Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. (11230712)
2001
8
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. (11520371)
2001
9
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (10514386)
1999
10
Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with Gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. (9067723)
1997
11
Squamous cell carcinoma of the cervix metastatic to an ovarian Brenner tumor. (7617659)
1995
12
A case of ovarian Brenner tumor with stromal estrogenic activity. (8092962)
1994
13
The histologic features and histogenesis of malignant ovarian Brenner tumor. (3100186)
1986
14
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
15
The ovarian Brenner tumor; its gross and microscopic pathology. (14789894)
1950

Genetic Variations for Ovarian Brenner Tumor

About this section

Expression for genes affiliated with Ovarian Brenner Tumor

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Brenner Tumor

Search GEO for disease gene expression data for Ovarian Brenner Tumor.

Pathways for genes affiliated with Ovarian Brenner Tumor

About this section

Compounds for genes affiliated with Ovarian Brenner Tumor

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine449.1KRT20, KRT7
2hematoxylin449.1KRT20, KRT7
3b 723449.0KRT7, KRT20
4streptavidin448.8KRT20, KRT7
5troglitazone44 28 59 1111.6KRT20, UPK2, UPK1B

GO Terms for genes affiliated with Ovarian Brenner Tumor

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.1KRT20, KRT7
2apical plasma membraneGO:0163248.2UPK3A, UPK2, UPK1A, UPK1B

Biological processes related to Ovarian Brenner Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:0308558.5UPK3A, UPK2, UPK1A, UPK1B

Products for genes affiliated with Ovarian Brenner Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Brenner Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet