MCID: OVR010
MIFTS: 32

Ovarian Brenner Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Ovarian Brenner Tumor

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NIH Rare Diseases:41 A brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary.  brenner tumors of the ovary usually do not cause symptoms.  approximately 2% of all ovarian tumors are brenner tumors.  there are three forms of this tumor: benign, proliferative (low chance of spreading beyond the original location of the tumor), and malignant.  the current preferred term for benign brenner tumors of the ovary is transitional cell tumors.  these tumors usually occur in women ages 40 to 60 years.  treatment usually consists of surgery to remove the tumor.  if a brenner tumor has not spread into surrounding tissues or to more distant parts of the body, there is a good-to-excellent prognosis. last updated: 1/11/2012

MalaCards based summary: Ovarian Brenner Tumor, also known as brenner tumor, is related to transitional cell carcinoma and adenocarcinoma. An important gene associated with Ovarian Brenner Tumor is UPK3A (uroplakin 3A). The compounds mannose and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include ovary and cervix, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Ovarian Brenner Tumor

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Ovarian Brenner Tumor, Aliases & Descriptions:

Name: Ovarian Brenner Tumor 9 41 11
Brenner Tumor 9 43 60
Brenner Tumor of Ovary 9 41
 
Brenner Tumor Nos 9
Brenner Tumors 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:2636
MeSH33 D001948

Related Diseases for Ovarian Brenner Tumor

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Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Ovarian Brenner Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.8UPK2, UPK1B
2adenocarcinoma30.1UPK3A, KRT20, KRT7
3malignant ovarian brenner tumor10.6
4struma ovarii10.5
5testicular brenner tumor10.4
6brenner tumor of the vagina10.4
7cystic teratoma10.3
8teratoma10.3
9breast cancer10.3
10endometrial stromal sarcoma10.3
11leiomyomatosis10.3
12sarcoma10.3
13nephrogenic adenoma10.2UPK3A, KRT7
14cystitis10.2UPK2, UPK1A
15systemic lupus erythematosus10.1
16brooke-spiegler syndrome10.1
17cystadenoma10.1
18hypercalcemia10.1
19gonadoblastoma10.1
20breast lymphoma10.1
21breast adenocarcinoma10.1
22endometrial adenocarcinoma10.1
23gonadal dysgenesis10.1
24lupus erythematosus10.1
25papillary adenocarcinoma10.1
26peritonitis10.1
27bladder cancer, somatic10.1UPK3A, KRT20
28bladder adenocarcinoma10.0KRT7, KRT20
29mammary paget's disease10.0KRT20, KRT7
30signet ring cell adenocarcinoma10.0KRT7, KRT20
31mucinous cystadenocarcinoma10.0KRT20, KRT7
32paget disease, extramammary10.0KRT20, KRT7
33pancreatic ductal carcinoma10.0KRT20, KRT7
34pseudomyxoma peritonei10.0KRT7, KRT20
35bronchiolo-alveolar adenocarcinoma10.0KRT20, KRT7
36cervical adenocarcinoma10.0KRT7, KRT20
37tubular adenocarcinoma10.0KRT20, KRT7
38abrikosov's tumor10.0KRT7, KRT20
39adenosquamous carcinoma10.0KRT7, KRT20
40large cell carcinoma10.0KRT7, KRT20
41salivary gland adenoid cystic carcinoma10.0KRT7, KRT20
42oxyphilic adenoma10.0KRT7, KRT20
43neuroendocrine tumor10.0KRT20, KRT7
44barrett esophagus/esophageal adenocarcinoma10.0KRT20, KRT7
45mesothelioma, somatic10.0KRT20, KRT7
46mesothelioma10.0KRT7, KRT20
47papillary carcinoma10.0KRT20, KRT7
48cholangiocarcinoma10.0KRT7, KRT20
49basal cell carcinoma9.9KRT7, KRT20
50gastric adenocarcinoma9.9KRT20, KRT7

Graphical network of the top 20 diseases related to Ovarian Brenner Tumor:



Diseases related to ovarian brenner tumor

Symptoms for Ovarian Brenner Tumor

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Drugs & Therapeutics for Ovarian Brenner Tumor

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Drug clinical trials:

Search ClinicalTrials for Ovarian Brenner Tumor

Search NIH Clinical Center for Ovarian Brenner Tumor

Genetic Tests for Ovarian Brenner Tumor

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Anatomical Context for Ovarian Brenner Tumor

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MalaCards organs/tissues related to Ovarian Brenner Tumor:

31
Ovary, Cervix

Animal Models for Ovarian Brenner Tumor or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Brenner Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0KRT7, UPK2, UPK3A

Publications for Ovarian Brenner Tumor

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Articles related to Ovarian Brenner Tumor:

(show all 14)
idTitleAuthorsYear
1
Different staining patterns of ovarian Brenner tumor and the associated mucinous tumor. (25596159)
2015
2
Malignant ovarian Brenner tumor. A case report evaluated with (18)F-FDG PET/CT. (25890890)
2015
3
FDG PET/CT of a benign ovarian Brenner tumor. (22920385)
2012
4
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. (17581415)
2007
5
Left ovarian Brenner tumor. (16302335)
2005
6
Transitional cell carcinoma of the endometrium associated with a benign ovarian Brenner tumor: a case report. (11230712)
2001
7
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use. (11520371)
2001
8
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. (10514386)
1999
9
Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with Gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. (9067723)
1997
10
Squamous cell carcinoma of the cervix metastatic to an ovarian Brenner tumor. (7617659)
1995
11
A case of ovarian Brenner tumor with stromal estrogenic activity. (8092962)
1994
12
The histologic features and histogenesis of malignant ovarian Brenner tumor. (3100186)
1986
13
The coexistence of an ovarian Brenner tumor and endometrial stromal sarcoma. (4542422)
1973
14
The ovarian Brenner tumor; its gross and microscopic pathology. (14789894)
1950

Variations for Ovarian Brenner Tumor

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Expression for genes affiliated with Ovarian Brenner Tumor

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Search GEO for disease gene expression data for Ovarian Brenner Tumor.

Pathways for genes affiliated with Ovarian Brenner Tumor

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Compounds for genes affiliated with Ovarian Brenner Tumor

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Sources:
43Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 12DrugBank
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Compounds related to Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1mannose439.5KRT7, UPK1A
2mucicarmine439.2KRT20, KRT7
3b 723439.2KRT20, KRT7
4streptavidin439.1KRT7, KRT20
5hematoxylin439.0KRT20, KRT7
6formaldehyde43 249.8KRT20, KRT7
7troglitazone43 28 59 1211.7KRT20, UPK2, UPK1B

GO Terms for genes affiliated with Ovarian Brenner Tumor

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Cellular components related to Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.1KRT20, KRT7
2apical plasma membraneGO:00163248.4UPK2, UPK3A, UPK1A, UPK1B
3extracellular vesicular exosomeGO:00700628.2UPK1B, UPK1A, UPK3A, UPK2

Biological processes related to Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:00308558.5UPK2, UPK3A, UPK1A, UPK1B

Molecular functions related to Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.3KRT7, UPK1B

Products for genes affiliated with Ovarian Brenner Tumor

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Sources for Ovarian Brenner Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet