MCID: OVR042
MIFTS: 73

Ovarian Cancer malady

Summaries for Ovarian Cancer

Sources:
34MedlinePlus, 3CDC, 46Novus Biologicals, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards: Ovarian Cancer, also known as ovarian carcinoma, is related to peritoneal carcinoma and adenocarcinoma. An important gene associated with Ovarian Cancer is RRAS2 (related RAS viral (r-ras) oncogene homolog 2), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cyclophosphamide and cisplatin and the compounds estrogen and paclitaxel have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and tumorigenesis.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later. When cancer starts in the ovaries, it is called ovarian cancer. Women have two ovaries that are located in the pelvis, one on each side of the uterus. The ovaries make female hormones and produce eggs.

Novus Biologicals:46 Tumor markers can be found in the body when cancer is present. They are most often found in the blood or urine, but can also be found in tumors and other tissues. High level of the tumor marker CA125 in the blood strongly suggests ovarian cancer. CA125 is an antigen present on 80% of non-mucinous ovarian carcinomas.

Wikipedia:64 Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early... more...

Description from OMIM:47 167000

Aliases & Classifications for Ovarian Cancer

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

ovarian cancer 8 43 47 10 45 34
ovarian carcinoma 8 43 47 45
neoplasm of ovary 8 22
ovarian neoplasm 8 61
primary malignant neoplasm of ovary and other uterine adnexa 8
ovarian cancer, susceptibility to 9
malignant neoplasm of ovary 61
malignant tumour of ovary 8
epithelial ovarian cancer 61
malignant tumor of ovary 8
malignant ovarian tumor 8
primary ovarian cancer 8
tumor of the ovary 8
ovarian neoplasms 45
ovary neoplasm 8
ovary cancer 8


Related Diseases for Ovarian Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 295)
idRelated DiseaseScoreTop Affiliating Genes
1peritoneal carcinoma30.8BRCA2, BRCA1
2adenocarcinoma30.7CDH1, CTNNB1, BRCA2, BRCA1, MUC16
3brca1 and brca2 hereditary breast and ovarian cancer30.3BRCA1, BRCA2
4wilms tumor30.3BRCA2, CTNNB1
5papillary carcinoma30.2CDH1, BRCA2, MUC16
6male breast cancer30.2BRCA2, BRCA1
7breast-ovarian cancer, familial, 230.2BRCA2
8multiple endocrine neoplasia29.9BRCA2
9stomach cancer29.9CDH1
10meigs syndrome29.9MUC16
11ovarian epithelial cancer11.4
12hereditary breast ovarian cancer11.0
13vascular cancer10.8
14sertoli cell tumor10.8
15sertoli-leydig cell tumor10.8
16breast cancer susceptibility10.7
17mixed germ cell tumor10.7
18hypoxia10.7
19ovarian endometriosis10.6
20familial breast cancer10.6
21germ cell tumors10.6
22colorectal cancer10.6
23malignant germ cell tumor10.6
24oral cancer10.6
25ovarian cancer, somatic10.6
26breast cancer, early-onset10.5
27malignant mixed mullerian tumor10.5
28sporadic breast cancer10.5
29thrombocytosis10.5
30adenomatoid tumor10.4
31primary peritoneal carcinoma10.4
32n syndrome10.4
33cerebellar degeneration10.4
34paraneoplastic cerebellar degeneration10.4
35small cell carcinoma10.4
36ovarian brenner tumor10.3
37amenorrhea10.3
38growing teratoma syndrome10.3
39ovarian lymphoma10.3
40clear cell adenocarcinoma10.3
41ovarian clear cell adenocarcinoma10.3
42breast-ovarian cancer, familial, 110.3
43colon cancer, advanced10.3
44neuroendocrine carcinoma10.2
45smooth muscle tumor10.2
46ovary rhabdomyosarcoma10.2
47bilateral breast cancer10.2
48transitional cell carcinoma10.2
49adenocarcinoid tumor10.2
50young syndrome10.2

Graphical network of the top 20 diseases related to Ovarian Cancer:



Diseases related to ovarian cancer

Clinical Features for Ovarian Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

167000

Drugs & Therapeutics for Ovarian Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Ovarian Cancer

Sources:
22GTR
See all sources

Genetic tests related to Ovarian Cancer:

id Genetic test Affiliating Genes
1 Neoplasm Of Ovary22

Anatomical Context for Ovarian Cancer

Animal Models for Ovarian Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ovarian Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.3EEF1A2, BRCA1, CTNNB1, GPR68, BRCA2, RRAS2
2MP:000200612.1BRCA1, BRCA2, CTNNB1, BARD1, DPH1, CDH1
3MP:000538012.0TSHZ2, BRCA1, BRCA2, CTNNB1, BARD1, CDH1

Publications for Ovarian Cancer

Sources:
51PubMed
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Articles related to Ovarian Cancer:

(show top 50)    (show all 5285)
idTitleAuthorsYear
1
In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome. (24434149)
2014
2
Expression of the Homeobox Gene HOXA9 in Ovarian Cancer Induces Peritoneal Macrophages to Acquire an M2 Tumor-Promoting Phenotype. (24332016)
2014
3
miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27(kip1.) (24137356)
2013
4
Coming into focus: the nonovarian origins of ovarian cancer. (24131966)
2013
5
Methylation of OPCML promoter in ovarian cancer tissues predicts poor patient survival. (24327526)
2013
6
NuMA overexpression in epithelial ovarian cancer. (22719996)
2012
7
Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer. (21618518)
2012
8
Mitochondrial transcription factor A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer. (22098591)
2012
9
Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites. (22901285)
2012
10
A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer. (21945552)
2011
11
Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer. (21324516)
2011
12
The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. (21863213)
2011
13
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. (20388781)
2010
14
Front-line bevacizumab in serous epithelial ovarian cancer: biomarker analysis of the FINAVAST trial. (20393027)
2010
15
The interaction of coagulation factor XII and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer. (20233624)
2010
16
Breast cancer susceptibility variants alter risk in familial ovarian cancer. (20502973)
2010
17
Human kallikrein related peptidases 6 and 13 in combination withCA125 is a more sensitive test for ovarian cancer than CA125 alone. (20037204)
2009
18
Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer. (19383346)
2008
19
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth. (17974506)
2008
20
Prognostic significance of fascin expression in advanced poorly differentiated serous ovarian cancer. (18630479)
2008
21
Assessment of expression of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LH/hCGR) and hCG protein in ovarian cancer tissues]. (18411916)
2007
22
VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent. (17559911)
2007
23
The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families. (17319787)
2007
24
Loss of p53 and overexpression of EphA2 predict poor prognosis for ovarian cancer patients. (17426437)
2007
25
Heparan sulphate synthetic and editing enzymes in ovarian cancer. (17437011)
2007
26
Expression and significance of the protein and mRNA of metastasis suppressor gene ME491/CD63 and integrin alpha5 in ovarian cancer tissues. (17624082)
2007
27
C-reactive protein concentrations and subsequent ovarian cancer risk. (17400857)
2007
28
Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients. (15671559)
2005
29
Androgen mediation of thrombocytosis in epithelial ovarian cancer biology. (16299230)
2005
30
Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. (16044148)
2005
31
Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (15788735)
2005
32
Inhibitory effect of coxsackie adenovirus receptor on invasion and metastasis phenotype of ovarian cancer cell line SKOV3. (15934317)
2005
33
Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts. (15010881)
2004
34
Hereditary ovarian cancer in Poland. (12918074)
2003
35
Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression. (12963992)
2003
36
High preoperative plasma concentration of tissue plasminogen activator (tPA) is an independent marker for shorter overall survival in patients with ovarian cancer. (14529669)
2003
37
The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer. (12142725)
2002
38
The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. (11221880)
2001
39
Urine GABA levels in ovarian cancer patients: elevated GABA in malignancy. (11121859)
2001
40
Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down-regulated in epithelial ovarian cancers. (11101152)
2000
41
Activity of cisplatin and ICI 182,780 on estrogen receptor negative ovarian cancer cells: cell cycle and cell replication rate perturbation, chromatin texture alteration and apoptosis induction. (10585591)
2000
42
An identical novel mutation in BRCA1 and a common haplotype in familial ovarian cancer in non-Ashkenazi Jews. (9667663)
1998
43
Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor beta 1 in vitro. (11245077)
1998
44
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. (8640795)
1996
45
Pelvic inflammatory disease and risk of ovarian cancer. (8824371)
1996
46
Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer. (9816013)
1995
47
Screening for ovarian cancer: what are the optimal surrogate endpoints for clinical trials? (8747401)
1995
48
Interferon-gamma suppresses expression of the HER-2 oncogene in ovarian cancer cells]. (1355379)
1992
49
Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. II. Relationship between receptor expression and response to epidermal growth factor. (2003535)
1991
50
Hormonal factors and risk of ovarian germ cell cancer in young women. (3390378)
1988

Genetic Variations for Ovarian Cancer

Expression for genes affiliated with Ovarian Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Cancer

Search GEO for disease gene expression data for Ovarian Cancer.

Pathways for genes affiliated with Ovarian Cancer

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Ovarian Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1estrogen4512.0BRCA1, BRCA2, CTNNB1, BARD1, MUC16, CDH1
2paclitaxel45 50 1113.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
3paraffin4511.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
4cisplatin45 50 60 1114.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
5progesterone45 60 29 11 2415.7BRCA1, BRCA2, CTNNB1, MUC16, CDH1
6indole-3-carbinol4511.7CDH1, CTNNB1, BRCA2, BRCA1
7p0024511.7BRCA1, BRCA2, CTNNB1, CDH1
8testosterone45 60 11 2414.6BRCA1, BRCA2, CTNNB1, MUC16, CDH1
9agar4511.6BRCA1, CTNNB1, CDH1, RRAS2
10tamoxifen45 50 29 1114.5BRCA1, BRCA2, CTNNB1, CDH1
11sodium bisulfite4511.5CDH1, CTNNB1, BRCA1
12leptomycin b45 6012.4CDH1, CTNNB1, BRCA1
134-hydroxytamoxifen4511.4CTNNB1, BRCA2, BRCA1
14bleomycin45 1112.3BRCA1, BRCA2, CTNNB1
15adpribose4511.3CTNNB1, BRCA2, BRCA1
16nocodazole45 1112.2BRCA1, CTNNB1, CDH1
17chlorophyllin4511.2CDH1, CTNNB1
18cyclopamine45 6012.1CTNNB1, CDH1
19p0034511.1CDH1, BRCA2, BRCA1
20resveratrol45 60 11 2414.1CTNNB1, BRCA2, BRCA1
21doxorubicin45 50 1113.0CDH1, MUC16, CTNNB1, BRCA1
22adriamycin4511.0CTNNB1
23exisulind4510.8CTNNB1, CDH1

GO Terms for genes affiliated with Ovarian Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-A complexGO:07053110.9BARD1, BRCA1
2BRCA1-BARD1 complexGO:03143610.8BARD1, BRCA1
3catenin complexGO:01634210.6CDH1, CTNNB1

Biological processes related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168111.1CDH1, CTNNB1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.9BRCA2, BRCA1
3regulation of protein localization to cell surfaceGO:200000810.8CDH1, CTNNB1
4protein K6-linked ubiquitinationGO:08502010.6BARD1, BRCA1

Products for genes affiliated with Ovarian Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet