MCID: OVR042
MIFTS: 79

Ovarian Cancer malady

Cancer diseases category

Summaries for Ovarian Cancer

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33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards: Ovarian Cancer, also known as ovarian carcinoma, is related to breast cancer and peritonitis. An important gene associated with Ovarian Cancer is RRAS2 (related RAS viral (r-ras) oncogene homolog 2), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cyclophosphamide and cisplatin and the compounds estrogen and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and testes, and related mouse phenotypes are cellular and tumorigenesis.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Novus Biologicals:45 Tumor markers can be found in the body when cancer is present. They are most often found in the blood or urine, but can also be found in tumors and other tissues. High level of the tumor marker CA125 in the blood strongly suggests ovarian cancer. CA125 is an antigen present on 80% of non-mucinous ovarian carcinomas.

Wikipedia:63 Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early... more...

Description from OMIM:46 167000

Aliases & Classifications for Ovarian Cancer

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 22GTR, 60UMLS, 9diseasecard, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian cancer 8 42 46 10 44 33
ovarian carcinoma 8 42 46 44
neoplasm of ovary 8 22
ovarian neoplasm 8 60
primary malignant neoplasm of ovary and other uterine adnexa 8
ovarian cancer, susceptibility to 9
malignant neoplasm of ovary 60
malignant tumour of ovary 8
epithelial ovarian cancer 60
malignant tumor of ovary 8
malignant ovarian tumor 8
primary ovarian cancer 8
tumor of the ovary 8
ovary neoplasm 8
ovary cancer 8


Related Diseases for Ovarian Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Ovarian Cancer family:

Ovarian Benign Neoplasm

Diseases related to Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9CDH1, MUC16, CTNNB1, BRCA2, BRCA1
2peritonitis31.2MUC16
3endometriosis30.9MUC16
4brca1 and brca2 hereditary breast and ovarian cancer30.8BRCA1, BRCA2
5cervical cancer30.7MUC16
6adenocarcinoma30.7CDH1, MUC16, CTNNB1, BRCA2, BRCA1
7fallopian tube cancer30.6BRCA2, BRCA1
8colon cancer30.6BRCA1, BRCA2, CTNNB1, CDH1
9lynch syndrome30.5BRCA1, BRCA2
10endometrial carcinoma30.2BRCA1, BRCA2, CTNNB1, MUC16, CDH1
11papillary carcinoma30.2BRCA2, MUC16, CDH1
12male breast cancer30.2BRCA2, BRCA1
13breast-ovarian cancer, familial, 230.2BRCA2
14ovarian cystadenoma30.0BRCA1, MUC16
15meigs syndrome30.0MUC16
16leiomyosarcoma29.8MUC16
17stomach cancer29.8CDH1
18hereditary breast ovarian cancer10.9
19endodermal sinus tumor10.9
20leydig cell tumor10.8
21vascular cancer10.8
22sertoli cell tumor10.8
23ovarian disease10.8
24sertoli-leydig cell tumor10.7
25cell type cancer10.7
26ovarian endometriosis10.6
27colorectal cancer10.6
28lung cancer10.6
29prostate cancer10.5
30prostatitis10.5
31primitive neuroectodermal tumor10.5
32ovarian cyst10.5
33sporadic breast cancer10.5
34cervicitis10.5
35lymph node cancer10.5
36thrombocytosis10.4
37adenomatoid tumor10.4
38ovarian small cell carcinoma10.4
39small cell carcinoma10.3
40ovarian brenner tumor10.3
41amenorrhea10.3
42dysgerminoma of ovary10.3
43glomus tumor10.3
44peripheral primitive neuroectodermal tumor10.3
45ovarian lymphoma10.3
46breast disease10.3
47pelvic inflammatory disease10.3
48ovarian cancer, somatic10.3
49clear cell adenocarcinoma10.2
50ovarian clear cell adenocarcinoma10.2

Graphical network of the top 20 diseases related to Ovarian Cancer:



Diseases related to ovarian cancer

Clinical Features for Ovarian Cancer

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46OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Ovarian Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Ovarian Cancer

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22GTR
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Genetic tests related to Ovarian Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Ovary22

Anatomical Context for Ovarian Cancer

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32MalaCards
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MalaCards organs/tissues related to Ovarian Cancer:

32
Breast, Ovary, Testes, Endothelial, Prostate, Lung, T cells, Colon, Lymph node, Bone, Thyroid, Testis, Monocytes, Bone marrow, Pituitary, Appendix, Brain, Liver, Heart, Cortex, Cervix, Smooth muscle, Nk cells, Spleen, Eye, Uterus, Myeloid

Animal Models for Ovarian Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.3BRCA1, BRCA2, CTNNB1, PHF13, BARD1, DPH1
2MP:000200612.1GPR68, BRCA1, BRCA2, CTNNB1, BARD1, DPH1
3MP:000538012.0BRCA2, CTNNB1, BARD1, DPH1, CDH1, TSHZ2

Publications for Ovarian Cancer

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50PubMed
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Articles related to Ovarian Cancer:

(show top 50)    (show all 5285)
idTitleAuthorsYear
1
The Anti-tumoral Efficacy of a Docetaxel-loaded Liposomal Drug Delivery System Modified with Transferrin for Ovarian Cancer. (24154938)
2013
2
microRNA-199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mammalian target of rapamycin. (24137412)
2013
3
Evaluation of rare variants in the new fanconi anemia gene ERCC4 (FANCQ) as familial breast/ovarian cancer susceptibility alleles. (24027083)
2013
4
Dermatomyositis as presenting feature of ovarian cancer, treated with neo-adjuvant chemotherapy and interval debulking surgery. (24371708)
2013
5
Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: involvement of p38 MAPK activation. (23338561)
2013
6
Decreased concentrations of retinol-binding protein 4 in sera of epithelial ovarian cancer patients: a potential biomarker identified by proteomics. (22020625)
2012
7
Does expression of the retrogene UTP14c in the ovary pre-dispose women to ovarian cancer? (22285623)
2012
8
Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer. (21933447)
2011
9
Ovarian cancer-associated polymorphisms in the BNC2 gene among women with endometriosis. (21642636)
2011
10
FGFR2 mutations are rare across histologic subtypes of ovarian cancer. (20106510)
2010
11
Up-regulation of stromal versican expression in advanced stage serous ovarian cancer. (20619446)
2010
12
Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer. (21041183)
2010
13
Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. (19769630)
2009
14
Pathogenesis of ovarian cancer: clues from selected overexpressed genes. (20001801)
2009
15
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1. (19368128)
2009
16
Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer? (18288924)
2008
17
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. (18765524)
2008
18
Effects of IL-18 gene transfection on the proliferation in vitro and tumorigenesis in vivo of mouse ovarian cancer cell line OVHM]. (18538088)
2008
19
Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor. (18283637)
2008
20
Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks. (17063264)
2007
21
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. (17308128)
2007
22
Expression and clinical significance of uPA and PAI-1 in epithelial ovarian cancer]. (17355798)
2007
23
CAG repeat length in exon 1 of the androgen receptor gene is related to age of diagnosis but not germ line BRCA1 mutation status in ovarian cancer. (16515589)
2006
24
Inhibitory effects of antisense MMP-9 oligodeoxynucleotides on invasiveness and adherence of ovarian cancer cells]. (17274370)
2006
25
Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients. (16788846)
2006
26
Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutations. (16492929)
2006
27
No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. (16239061)
2006
28
Use of Ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. (16757360)
2006
29
Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer. (16821592)
2006
30
Maintenance of ovarian function and risk of premature menopause related to cancer treatment. (15784817)
2005
31
Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer. (15047239)
2004
32
EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. (14639658)
2003
33
Glucocorticoid modulation of extracellular signal-regulated protein kinase 1/2 and p38 in human ovarian cancer HO-8910 cells. (12875695)
2003
34
Ovarian metastasis originating from bronchioloalveolar carcinoma: a rare presentation of lung cancer. (14523061)
2003
35
Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. (12447990)
2003
36
Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells. (11850827)
2002
37
Conservation of the class I beta-tubulin gene in human populations and lack of mutations in lung cancers and paclitaxel-resistant ovarian cancers. (12467216)
2002
38
Evidence for hormone-responsive cleavage of gonadotropin-releasing hormone by the plasma membrane of ovarian cancer cells. (11956594)
2002
39
Cell-free 27 kDa heat shock protein (hsp27) and hsp27-cytochrome c complexes in the cervix of women with ovarian or endometrial cancer. (12432550)
2002
40
p53 Mutations and microsatellite instability in ovarian cancer: Yin and yang. (11303196)
2001
41
Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells: role of ERCC1-XPF. (11008124)
2000
42
Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. (11206843)
2000
43
Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel. (9779711)
1998
44
Synthesis and breakdown of fibrillar collagens: concomitant phenomena in ovarian cancer. (9667653)
1998
45
Glutathione, glutathione S-transferase alpha and pi, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer. (9103391)
1997
46
Binding of ovarian cancer cells to immobilized hyaluronic acid. (9298699)
1997
47
17 beta Hydroxysteroid dehydrogenase 1 "pseudogene" is differentially transcribed: still a candidate for the breast-ovarian cancer susceptibility gene (BRCA1). (8024576)
1994
48
Frequent allelic losses and mutations of the p53 gene in human ovarian cancer. (1680546)
1991
49
Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitro. (1717146)
1991
50
Immunohistochemical identification of CA125 and the F(ab')2 fragments of the murine monoclonal antibody OC125 in ovarian cancer tissue. (2200498)
1990

Genetic Variations for Ovarian Cancer

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Expression for genes affiliated with Ovarian Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer

Search GEO for disease gene expression data for Ovarian Cancer.

Pathways for genes affiliated with Ovarian Cancer

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Ovarian Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1estrogen4412.0BRCA1, BRCA2, CTNNB1, BARD1, MUC16, CDH1
2paclitaxel44 49 1113.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
3paraffin4411.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
4cisplatin44 49 59 1114.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
5progesterone44 59 28 11 2415.7BRCA1, BRCA2, CTNNB1, MUC16, CDH1
6indole-3-carbinol4411.7CDH1, CTNNB1, BRCA2, BRCA1
7p0024411.7BRCA1, BRCA2, CTNNB1, CDH1
8testosterone44 59 11 2414.6BRCA1, BRCA2, CTNNB1, MUC16, CDH1
9agar4411.6BRCA1, CTNNB1, CDH1, RRAS2
10tamoxifen44 49 28 1114.5BRCA1, BRCA2, CTNNB1, CDH1
11sodium bisulfite4411.5CDH1, CTNNB1, BRCA1
12leptomycin b44 5912.4CDH1, CTNNB1, BRCA1
134-hydroxytamoxifen4411.4CTNNB1, BRCA2, BRCA1
14bleomycin44 1112.3BRCA1, BRCA2, CTNNB1
15adpribose4411.3CTNNB1, BRCA2, BRCA1
16nocodazole44 1112.2BRCA1, CTNNB1, CDH1
17chlorophyllin4411.2CDH1, CTNNB1
18cyclopamine44 5912.1CTNNB1, CDH1
19p0034411.1CDH1, BRCA2, BRCA1
20resveratrol44 59 11 2414.1CTNNB1, BRCA2, BRCA1
21doxorubicin44 49 1113.0CDH1, MUC16, CTNNB1, BRCA1
22adriamycin4411.0CTNNB1
23exisulind4410.8CTNNB1, CDH1

GO Terms for genes affiliated with Ovarian Cancer

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16Gene Ontology
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Cellular components related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-A complexGO:07053110.9BARD1, BRCA1
2BRCA1-BARD1 complexGO:03143610.8BARD1, BRCA1
3catenin complexGO:01634210.6CDH1, CTNNB1

Biological processes related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168111.1CDH1, CTNNB1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.9BRCA2, BRCA1
3regulation of protein localization to cell surfaceGO:200000810.8CDH1, CTNNB1
4protein K6-linked ubiquitinationGO:08502010.6BARD1, BRCA1

Products for genes affiliated with Ovarian Cancer

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  • Antibodies
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  • Lysates
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Sources for Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet