MCID: OVR042
MIFTS: 81

Ovarian Cancer malady

Rare diseases, Cancer diseases categories

Summaries for Ovarian Cancer

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35MedlinePlus, 4CDC, 47Novus Biologicals, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards: Ovarian Cancer, also known as ovarian carcinoma, is related to breast cancer and adenocarcinoma. An important gene associated with Ovarian Cancer is RRAS2 (related RAS viral (r-ras) oncogene homolog 2), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The drugs cyclophosphamide and cisplatin and the compounds sodium bisulfite and chlorophyllin have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and testes, and related mouse phenotypes are tumorigenesis and embryogenesis.

CDC:4 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Novus Biologicals:47 Tumor markers can be found in the body when cancer is present. They are most often found in the blood or urine, but can also be found in tumors and other tissues. High level of the tumor marker CA125 in the blood strongly suggests ovarian cancer. CA125 is an antigen present on 80% of non-mucinous ovarian carcinomas.

Wikipedia:66 Ovarian cancer is when cancer forms from the ovary. It is due to the development of abnormal cells that... more...

Description from OMIM:48 167000

Aliases & Classifications for Ovarian Cancer

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9Disease Ontology, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 23GTR, 63UMLS, 10diseasecard, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian cancer 9 44 48 11 46 35
ovarian carcinoma 9 44 48 46
neoplasm of ovary 9 23
ovarian neoplasm 9 63
primary malignant neoplasm of ovary and other uterine adnexa 9
ovarian cancer, susceptibility to 10
malignant neoplasm of ovary 63
epithelial ovarian cancer 63
malignant tumour of ovary 9
malignant tumor of ovary 9
malignant ovarian tumor 9
primary ovarian cancer 9
tumor of the ovary 9
ovary neoplasm 9
ovary cancer 9


Related Diseases for Ovarian Cancer

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18GeneCards, 19GeneDecks
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Diseases in the Ovarian Cancer family:

Ovarian Benign Neoplasm

Diseases related to Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 346)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.4BRCA2, BRCA1, MUC16, CDH1, CTNNB1
2adenocarcinoma30.9BRCA2, BRCA1, MUC16, KLK8, CDH1, CTNNB1
3peritoneal carcinoma30.8BRCA1, BRCA2
4colorectal cancer30.7BRCA2, BRCA1, MUC16, CDH1, CTNNB1
5lynch syndrome30.7BRCA1, BRCA2
6fallopian tube cancer30.7BRCA2, BRCA1
7brca1 and brca2 hereditary breast and ovarian cancer30.6BRCA2, BRCA1
8colon cancer30.5BRCA2, BRCA1, CDH1, CTNNB1
9breast-ovarian cancer, familial, 230.4BRCA2
10endometrial carcinoma30.4CTNNB1, CDH1, MUC16
11pancreatic cancer30.4CTNNB1, CDH1, BRCA1, BRCA2
12bilateral breast cancer30.4BRCA1, BRCA2
13dysgerminoma30.3BRCA2, BRCA1
14prostate cancer30.3BRCA2, BRCA1, MUC16, CDH1, CTNNB1
15peutz-jeghers syndrome30.3BRCA2, CTNNB1
16papillary carcinoma30.3BRCA2, MUC16, CDH1
17male breast cancer30.3BRCA1, BRCA2
18ovarian cystadenoma30.3MUC16, BRCA1
19bloom syndrome30.2BRCA1, BRCA2
20li-fraumeni syndrome30.0BRCA1, BRCA2
21endodermal sinus tumor10.9
22leydig cell tumor10.8
23germ cell tumors10.8
24hereditary breast ovarian cancer10.8
25peritonitis10.8
26endotheliitis10.8
27sertoli-leydig cell tumor10.8
28mixed germ cell tumor10.7
29hypoxia10.6
30endometriosis10.6
31prostatitis10.6
32malignant germ cell tumor10.6
33sertoli cell tumor10.5
34primitive neuroectodermal tumor10.5
35malignant mixed mullerian tumor10.5
36cervicitis10.5
37adenomatoid tumor10.5
38thrombocytosis10.4
39breast cancer susceptibility10.4
40ovarian cyst10.4
41ovarian brenner tumor10.3
42fibroma10.3
43amenorrhea10.3
44glomus tumor10.3
45peripheral primitive neuroectodermal tumor10.3
46growing teratoma syndrome10.3
47cerebellar degeneration10.3
48paraneoplastic cerebellar degeneration10.3
49primary peritoneal carcinoma10.3
50pelvic inflammatory disease10.3

Graphical network of the top 20 diseases related to Ovarian Cancer:



Diseases related to ovarian cancer

Symptoms for Ovarian Cancer

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48OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Ovarian Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Ovarian Cancer

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23GTR
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Genetic tests related to Ovarian Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Ovary23

Anatomical Context for Ovarian Cancer

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34MalaCards
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MalaCards organs/tissues related to Ovarian Cancer:

34
Breast, Ovary, Testes, Endothelial, Lung, Lymph node, T cells, Liver, Prostate, Colon, Bone, Monocytes, Testis, Bone marrow, Pituitary, Thyroid, Appendix, Eye, Spleen, Nk cells, Uterus, Myeloid, Heart, Smooth muscle, Brain

Animal Models for Ovarian Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.5GPR68, RRAS2, BRCA2, BRCA1, DPH1, BARD1
2MP:000538010.5BRCA2, BRCA1, TSHZ2, DPH1, BARD1, CDH1
3MP:000538410.4GPR68, SEPT9, BRCA2, BRCA1, EEF1A2, DPH1
4MP:000539710.4GPR68, SEPT9, RRAS2, BRCA2, BRCA1, EEF1A2
5MP:001076810.4CTNNB1, SPIN1, SEPT9, BRCA2, BRCA1, NAPB
6MP:000538710.4GPR68, SEPT9, RRAS2, BRCA2, BRCA1, EEF1A2
7MP:000537810.3BRCA2, BRCA1, EEF1A2, DPH1, BARD1, CDH1
8MP:000363110.2BRCA2, BRCA1, NAPB, EEF1A2, DPH1, BARD1
9MP:000537910.1GPR68, BRCA2, BRCA1, PHF13, CDH1, CTNNB1

Publications for Ovarian Cancer

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Sources:
53PubMed
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Articles related to Ovarian Cancer:

(show top 50)    (show all 4900)
idTitleAuthorsYear
1
An Analysis of Polymorphisms Within the Wnt Signaling Pathway in Relation to Ovarian Cancer Risk in a Polish Population. (24078348)
2013
2
A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first. (24137335)
2013
3
Hope, quality of life, and benefit from treatment in women having chemotherapy for platinum-resistant/refractory recurrent ovarian cancer: the gynecologic cancer intergroup symptom benefit study. (24107972)
2013
4
PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. (23340297)
2013
5
Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis. (22733497)
2012
6
Nerve growth factor stimulates cellular proliferation of human epithelial ovarian cancer. (22411587)
2012
7
Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-I_B activation. (22228447)
2012
8
Sodium arsenite A+ hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. (22331493)
2012
9
Matrix metalloproteinase-9 expression correlates with prognosis and involved in ovarian cancer cell invasion. (22832979)
2012
10
Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. (22465665)
2012
11
Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2. (22396544)
2012
12
BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer. (21920589)
2011
13
An exploration of the communication preferences regarding genetic testing in individuals from families with identified breast/ovarian cancer mutations. (20878485)
2011
14
37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells. (21193558)
2011
15
The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer. (21451362)
2011
16
Jagged1 expression regulated by Notch3 and Wnt/I^-catenin signaling pathways in ovarian cancer. (20953350)
2010
17
Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. (20118984)
2010
18
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (20852632)
2010
19
The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells. (19147209)
2009
20
Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study. (19190154)
2009
21
A novel BRCA1 mutation in a Spanish patient with ovarian cancer. (18278587)
2009
22
Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction. (19622337)
2009
23
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. (19208843)
2009
24
Significance of expression of THY1 protein in epithelial ovarian cancer]. (19615261)
2009
25
Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. (18187487)
2008
26
A case of ovarian cancer associated with hypercalcemia. (18845526)
2008
27
Combined staining of TAG-72, MUC1, and CA125 improves labeling sensitivity in ovarian cancer: antigens for multi-targeted antibody-guided therapy. (17478446)
2007
28
Yang,C.Q., Chan,K.Y.K., Ngan,H.Y.S., Khoo,U.S., Chiu,P.M., Chan,Q.K.Y., Xue,W.C., and Cheung,A.N.Y. Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility. Carcinogenesis, July 2006; 27, 1502 1506. (17307804)
2007
29
TP53 mutations and codon 72 genotype--impact on survival among ovarian cancer patients. (17488735)
2007
30
Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. (16740297)
2006
31
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. (17088436)
2006
32
PIK3CA mutations in ovarian cancer. (16203798)
2005
33
Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells. (14676209)
2004
34
Activity of telomerase and extracellular regulated protein kinases in parental and drug resistant cells of leukemia and ovarian cancer. (15228655)
2004
35
Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation. (15243131)
2004
36
Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. (12920070)
2003
37
Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells. (12694652)
2003
38
Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer. (12969782)
2003
39
Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype. (12404104)
2002
40
Relationship between the expression of connexin 43 and bystander effect of suicide gene therapy in ovarian cancer]. (11769669)
2001
41
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. (11103784)
2000
42
Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells. (10702246)
2000
43
Mutation analysis of the Smad3 gene in human ovarian cancers. (10536178)
1999
44
Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model. (10473101)
1999
45
Expression analysis of protein kinase C isozymes and multidrug resistance associated genes in ovarian cancer cells. (9615708)
1998
46
Overexpression of the oncogene c-erbB-2 (HER2/neu) and response to chemotherapy in patients with ovarian cancer. (9475194)
1998
47
Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1. (9516977)
1998
48
Screening for ESR mutations in breast and ovarian cancer patients. (9195227)
1997
49
Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. (8988179)
1997
50
A phase I/II study of dose-intense paclitaxel with cisplatin and cyclophosphamide as initial therapy of poor-prognosis advanced-stage epithelial ovarian cancer. (8751547)
1996

Variations for Ovarian Cancer

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Ovarian Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
3AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551

Expression for genes affiliated with Ovarian Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer

Search GEO for disease gene expression data for Ovarian Cancer.

Pathways for genes affiliated with Ovarian Cancer

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters
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Pathways related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4BRCA2, BRCA1
2
Show member pathways
10.4BRCA1, BRCA2
310.4BARD1, BRCA1
410.4CTNNB1, CDH1
510.4CTNNB1, CDH1
6
Show member pathways
10.4BARD1, BRCA1, BRCA2
710.4BRCA2, BRCA1, BARD1
8
Show member pathways
10.4BARD1, BRCA1, BRCA2
9
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
10.4CTNNB1, CDH1, RRAS2
1010.4RRAS2, CDH1, CTNNB1
1110.4CTNNB1, CDH1, SEPT9
12
Show member pathways
Signaling Pathways in Glioblastoma39
10.4BRCA2, BRCA1, CDH1, CTNNB1
1310.4CTNNB1, CDH1, BARD1, BRCA1, BRCA2

Compounds for genes affiliated with Ovarian Cancer

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Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite4610.9CTNNB1, CDH1, BRCA1
2chlorophyllin4610.9CTNNB1, CDH1
3indole-3-carbinol4610.8CTNNB1, CDH1, BRCA1, BRCA2
4p0024610.8CTNNB1, CDH1, BRCA1, BRCA2
5adriamycin4610.8BRCA2, BRCA1, CDH1, CTNNB1
6leptomycin b46 6211.8CTNNB1, CDH1, BRCA1
7agar4610.8RRAS2, BRCA1, CDH1, CTNNB1
84-hydroxytamoxifen4610.8CTNNB1, BRCA1, BRCA2
9paclitaxel46 52 1212.8BRCA2, BRCA1, MUC16, CDH1, CTNNB1
10paraffin4610.8BRCA2, BRCA1, MUC16, CDH1, CTNNB1
11cyclopamine46 6211.8CDH1, CTNNB1
12bleomycin46 1211.8BRCA2, BRCA1, CTNNB1
13cisplatin46 52 62 1213.8BRCA2, BRCA1, MUC16, CDH1, CTNNB1
14tamoxifen46 52 30 1213.8BRCA2, BRCA1, CDH1, CTNNB1
15adpribose4610.8CTNNB1, BRCA1, BRCA2
16progesterone46 30 62 25 1214.8BRCA2, BRCA1, MUC16, CDH1, CTNNB1
17nocodazole46 1211.8CTNNB1, CDH1, BRCA1
18estrogen4610.8BRCA2, BRCA1, MUC16, BARD1, CDH1, CTNNB1
19p0034610.8CDH1, BRCA1, BRCA2
20testosterone46 62 25 1213.8CTNNB1, CDH1, MUC16, BRCA1, BRCA2
21exisulind4610.8CDH1, CTNNB1
22resveratrol46 62 25 1213.8CTNNB1, BRCA1, BRCA2
23doxorubicin46 52 1212.7BRCA1, MUC16, CDH1, CTNNB1
24steroid4610.7CTNNB1, KLK8, MUC16, BRCA1, BRCA2
25gold4610.7MUC16, BRCA1, BRCA2
26genistein46 30 62 3 25 1215.7CTNNB1, CDH1, BRCA1, BRCA2
27docetaxel46 52 62 1213.7BRCA2, BRCA1, CDH1
28etodolac46 1211.7CTNNB1, CDH1
29mg 13246 6211.7BRCA1, CDH1, CTNNB1
30glutamine4610.7CTNNB1, CDH1, BRCA1, BRCA2
31gamma-linolenic acid46 2511.7CTNNB1, CDH1
328-oxoguanine4610.7BRCA2, BRCA1
335-methylcytosine46 2511.6BRCA1, CDH1
34daidzein4610.6BRCA2, BRCA1
35folate4610.5BRCA2, BRCA1, CDH1
36retinoic acid46 2511.5BRCA2, BRCA1, DPH1, CDH1, CTNNB1
375-aza-2deoxycytidine4610.5BRCA1, CDH1, CTNNB1
38dfmo46 30 6212.4CTNNB1, CDH1
39serine4610.4RRAS2, BRCA1, MUC16, KLK8, CDH1, CTNNB1
40lycopene46 2511.3BRCA1, BRCA2
41o6-methylguanine4610.1CDH1, BRCA2

GO Terms for genes affiliated with Ovarian Cancer

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17Gene Ontology
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Cellular components related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-BARD1 complexGO:03143610.5BARD1, BRCA1
2BRCA1-A complexGO:07053110.4BRCA1, BARD1
3catenin complexGO:01634210.3CDH1, CTNNB1
4cytoplasmGO:00573710.3BRCA2, BRCA1, FILIP1L, DPH1, BARD1, KLK8
5nucleusGO:00563410.0SPIN1, BRCA2, BRCA1, TSHZ2, EEF1A2, FILIP1L

Biological processes related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168110.5CTNNB1, CDH1, BRCA1
2regulation of protein localization to cell surfaceGO:200000810.5CTNNB1, CDH1
3protein K6-linked ubiquitinationGO:08502010.4BARD1, BRCA1
4positive regulation of transcription, DNA-templatedGO:04589310.4CTNNB1, CDH1, BRCA1, BRCA2
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.3BRCA2, BRCA1
6synapse organizationGO:05080810.1CTNNB1, KLK8

Products for genes affiliated with Ovarian Cancer

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Sources for Ovarian Cancer

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet