MCID: OVR042
MIFTS: 79

Ovarian Cancer malady

Cancer diseases category

Summaries for Ovarian Cancer

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Sources:
33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards: Ovarian Cancer, also known as ovarian carcinoma, is related to breast cancer and peritonitis. An important gene associated with Ovarian Cancer is RRAS2 (related RAS viral (r-ras) oncogene homolog 2), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cyclophosphamide and cisplatin and the compounds estrogen and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and testes, and related mouse phenotypes are cellular and tumorigenesis.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Novus Biologicals:45 Tumor markers can be found in the body when cancer is present. They are most often found in the blood or urine, but can also be found in tumors and other tissues. High level of the tumor marker CA125 in the blood strongly suggests ovarian cancer. CA125 is an antigen present on 80% of non-mucinous ovarian carcinomas.

Wikipedia:63 Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early... more...

Description from OMIM:46 167000

Aliases & Classifications for Ovarian Cancer

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 22GTR, 60UMLS, 9diseasecard, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian cancer 8 42 46 10 44 33
ovarian carcinoma 8 42 46 44
neoplasm of ovary 8 22
ovarian neoplasm 8 60
primary malignant neoplasm of ovary and other uterine adnexa 8
ovarian cancer, susceptibility to 9
malignant neoplasm of ovary 60
malignant tumour of ovary 8
epithelial ovarian cancer 60
malignant tumor of ovary 8
malignant ovarian tumor 8
primary ovarian cancer 8
tumor of the ovary 8
ovary neoplasm 8
ovary cancer 8


Related Diseases for Ovarian Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Ovarian Cancer family:

Ovarian Benign Neoplasm

Diseases related to Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9CDH1, MUC16, CTNNB1, BRCA2, BRCA1
2peritonitis31.2MUC16
3endometriosis30.9MUC16
4brca1 and brca2 hereditary breast and ovarian cancer30.8BRCA1, BRCA2
5cervical cancer30.7MUC16
6adenocarcinoma30.7CDH1, MUC16, CTNNB1, BRCA2, BRCA1
7fallopian tube cancer30.6BRCA2, BRCA1
8colon cancer30.6BRCA1, BRCA2, CTNNB1, CDH1
9lynch syndrome30.5BRCA1, BRCA2
10endometrial carcinoma30.2BRCA1, BRCA2, CTNNB1, MUC16, CDH1
11papillary carcinoma30.2BRCA2, MUC16, CDH1
12male breast cancer30.2BRCA2, BRCA1
13breast-ovarian cancer, familial, 230.2BRCA2
14ovarian cystadenoma30.0BRCA1, MUC16
15meigs syndrome30.0MUC16
16leiomyosarcoma29.8MUC16
17stomach cancer29.8CDH1
18hereditary breast ovarian cancer10.9
19endodermal sinus tumor10.9
20leydig cell tumor10.8
21vascular cancer10.8
22sertoli cell tumor10.8
23ovarian disease10.8
24sertoli-leydig cell tumor10.7
25cell type cancer10.7
26ovarian endometriosis10.6
27colorectal cancer10.6
28lung cancer10.6
29prostate cancer10.5
30prostatitis10.5
31primitive neuroectodermal tumor10.5
32ovarian cyst10.5
33sporadic breast cancer10.5
34cervicitis10.5
35lymph node cancer10.5
36thrombocytosis10.4
37adenomatoid tumor10.4
38ovarian small cell carcinoma10.4
39small cell carcinoma10.3
40ovarian brenner tumor10.3
41amenorrhea10.3
42dysgerminoma of ovary10.3
43glomus tumor10.3
44peripheral primitive neuroectodermal tumor10.3
45ovarian lymphoma10.3
46breast disease10.3
47pelvic inflammatory disease10.3
48ovarian cancer, somatic10.3
49clear cell adenocarcinoma10.2
50ovarian clear cell adenocarcinoma10.2

Graphical network of the top 20 diseases related to Ovarian Cancer:



Diseases related to ovarian cancer

Clinical Features for Ovarian Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Ovarian Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Ovarian Cancer

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22GTR
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Genetic tests related to Ovarian Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Ovary22

Anatomical Context for Ovarian Cancer

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32MalaCards
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MalaCards organs/tissues related to Ovarian Cancer:

32
Breast, Ovary, Testes, Endothelial, Prostate, Lung, T cells, Colon, Lymph node, Bone, Thyroid, Testis, Monocytes, Bone marrow, Pituitary, Appendix, Brain, Liver, Heart, Cortex, Cervix, Smooth muscle, Nk cells, Spleen, Eye, Uterus, Myeloid

Animal Models for Ovarian Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.3BRCA1, BRCA2, CTNNB1, PHF13, BARD1, DPH1
2MP:000200612.1GPR68, BRCA1, BRCA2, CTNNB1, BARD1, DPH1
3MP:000538012.0BRCA2, CTNNB1, BARD1, DPH1, CDH1, TSHZ2

Publications for Ovarian Cancer

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50PubMed
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Articles related to Ovarian Cancer:

(show top 50)    (show all 5285)
idTitleAuthorsYear
1
Beyond bevacizumab: investigating new angiogenesis inhibitors in ovarian cancer. (24111925)
2014
2
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
3
Patient selection and targeted treatment in the management of platinum-resistant ovarian cancer. (24109193)
2013
4
Incidence and predictors of ovarian function recovery (OFR) in breast cancer (BC) patients with chemotherapy-induced amenorrhea (CIA) who switched from tamoxifen to exemestane. (23108951)
2013
5
Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose? (24202339)
2013
6
Hereditary breast and ovarian cancer: lessening the burden. (24298633)
2013
7
Recurrent epithelial ovarian cancer and hormone therapy. (24303498)
2013
8
Safety and efficacy of aprepitant, ramosetron, and dexamethasone for chemotherapy-induced nausea and vomiting in patients with ovarian cancer treated with paclitaxel/carboplatin. (24337621)
2013
9
Identifying microRNA/mRNA dysregulations in ovarian cancer. (22452920)
2012
10
Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction. (23239986)
2012
11
Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells. (21909139)
2012
12
Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. (21955482)
2011
13
Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. (22175896)
2011
14
Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome. (21787767)
2011
15
CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population]. (22384697)
2011
16
Two multidrug-resistance (ABCB1) gene polymorphisms as prognostic parameters in women with ovarian cancer. (20944127)
2010
17
Transient receptor potential channel C3 contributes to the progression of human ovarian cancer. (19151765)
2009
18
Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. (19276375)
2009
19
Immunopathogenesis of ovarian cancer. (19910891)
2009
20
Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer. (18953434)
2008
21
Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer. (19047092)
2008
22
Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion. (18260155)
2008
23
Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. (19016756)
2008
24
Association between genetic polymorphisms and ovarian cancer risk. (19031960)
2008
25
Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients. (17200349)
2007
26
Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer. (16819291)
2006
27
Interferon-gamma in combination with carboplatin and paclitaxel as a safe and effective first-line treatment option for advanced ovarian cancer: results of a phase I/II study. (16884360)
2006
28
Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial. (16061407)
2005
29
Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy. (16166317)
2005
30
EphA2 as a target for ovarian cancer therapy. (16300469)
2005
31
Elevated serum insulin-like growth factor binding protein-2 as a prognostic marker in patients with ovarian cancer. (15014034)
2004
32
Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. (15313912)
2004
33
Gene expression patterns that characterize advanced stage serous ovarian cancers. (14706684)
2004
34
Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells. (15372629)
2004
35
Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors in ovarian cancer and its correlation to human chorionic gonadotropin-doxorubicin sensitivity. (15284756)
2004
36
Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States). (12946038)
2003
37
Steroids and adrenomedullin growth patterns in human ovarian cancer cells: estrogenic-regulation assay. (14675694)
2003
38
Treatment of ovarian cancer cell line Skov3 with HSV-tk/GCV under the control of human telomerase reverse transcriptase gene promoter]. (12974091)
2003
39
Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. (12365003)
2002
40
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers. (11314036)
2001
41
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. (11429402)
2001
42
High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer. (10646867)
2000
43
Reduction of BRCA1 expression in sporadic ovarian cancer. (10684699)
2000
44
An unaffected individual from a breast/ovarian cancer family with germline mutations in both BRCA1 and BRCA2. (10733239)
2000
45
Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro. (10411105)
1999
46
In vivo studies of adenovirus-based p53 gene therapy for ovarian cancer. (9648587)
1998
47
Serum lipid-associated sialic acid (LSA) in diagnosing and monitoring ovarian cancer]. (7656393)
1995
48
Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue. (8188079)
1994
49
Primary peritoneal carcinoma after prophylactic oophorectomy in women with a family history of ovarian cancer. A report of the Gilda Radner Familial Ovarian Cancer Registry. (8467455)
1993
50
Carbon dioxide laser vaporization of diaphragmatic metastases for cytoreduction of ovarian epithelial cancer. (2216210)
1990

Genetic Variations for Ovarian Cancer

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Expression for genes affiliated with Ovarian Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer

Search GEO for disease gene expression data for Ovarian Cancer.

Pathways for genes affiliated with Ovarian Cancer

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Ovarian Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1estrogen4412.0BRCA1, BRCA2, CTNNB1, BARD1, MUC16, CDH1
2paclitaxel44 49 1113.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
3paraffin4411.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
4cisplatin44 49 59 1114.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
5progesterone44 59 28 11 2415.7BRCA1, BRCA2, CTNNB1, MUC16, CDH1
6indole-3-carbinol4411.7CDH1, CTNNB1, BRCA2, BRCA1
7p0024411.7BRCA1, BRCA2, CTNNB1, CDH1
8testosterone44 59 11 2414.6BRCA1, BRCA2, CTNNB1, MUC16, CDH1
9agar4411.6BRCA1, CTNNB1, CDH1, RRAS2
10tamoxifen44 49 28 1114.5BRCA1, BRCA2, CTNNB1, CDH1
11sodium bisulfite4411.5CDH1, CTNNB1, BRCA1
12leptomycin b44 5912.4CDH1, CTNNB1, BRCA1
134-hydroxytamoxifen4411.4CTNNB1, BRCA2, BRCA1
14bleomycin44 1112.3BRCA1, BRCA2, CTNNB1
15adpribose4411.3CTNNB1, BRCA2, BRCA1
16nocodazole44 1112.2BRCA1, CTNNB1, CDH1
17chlorophyllin4411.2CDH1, CTNNB1
18cyclopamine44 5912.1CTNNB1, CDH1
19p0034411.1CDH1, BRCA2, BRCA1
20resveratrol44 59 11 2414.1CTNNB1, BRCA2, BRCA1
21doxorubicin44 49 1113.0CDH1, MUC16, CTNNB1, BRCA1
22adriamycin4411.0CTNNB1
23exisulind4410.8CTNNB1, CDH1

GO Terms for genes affiliated with Ovarian Cancer

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16Gene Ontology
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Cellular components related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-A complexGO:07053110.9BARD1, BRCA1
2BRCA1-BARD1 complexGO:03143610.8BARD1, BRCA1
3catenin complexGO:01634210.6CDH1, CTNNB1

Biological processes related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168111.1CDH1, CTNNB1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.9BRCA2, BRCA1
3regulation of protein localization to cell surfaceGO:200000810.8CDH1, CTNNB1
4protein K6-linked ubiquitinationGO:08502010.6BARD1, BRCA1

Products for genes affiliated with Ovarian Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet