MCID: OVR042
MIFTS: 79

Ovarian Cancer malady

Cancer diseases category

Summaries for Ovarian Cancer

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33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards: Ovarian Cancer, also known as ovarian carcinoma, is related to breast cancer and peritonitis. An important gene associated with Ovarian Cancer is RRAS2 (related RAS viral (r-ras) oncogene homolog 2), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs chlorambucil and cisplatin and the compounds estrogen and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and testes, and related mouse phenotypes are cellular and tumorigenesis.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

Novus Biologicals:45 Tumor markers can be found in the body when cancer is present. They are most often found in the blood or urine, but can also be found in tumors and other tissues. High level of the tumor marker CA125 in the blood strongly suggests ovarian cancer. CA125 is an antigen present on 80% of non-mucinous ovarian carcinomas.

Wikipedia:63 Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early... more...

Description from OMIM:46 167000

Aliases & Classifications for Ovarian Cancer

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 22GTR, 60UMLS, 9diseasecard, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian cancer 8 42 46 10 44 33
ovarian carcinoma 8 42 46 44
neoplasm of ovary 8 22
ovarian neoplasm 8 60
primary malignant neoplasm of ovary and other uterine adnexa 8
ovarian cancer, susceptibility to 9
malignant neoplasm of ovary 60
malignant tumour of ovary 8
epithelial ovarian cancer 60
malignant tumor of ovary 8
malignant ovarian tumor 8
primary ovarian cancer 8
tumor of the ovary 8
ovary neoplasm 8
ovary cancer 8


Related Diseases for Ovarian Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Ovarian Cancer family:

Ovarian Benign Neoplasm

Diseases related to Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9CDH1, MUC16, CTNNB1, BRCA2, BRCA1
2peritonitis31.2MUC16
3endometriosis30.9MUC16
4brca1 and brca2 hereditary breast and ovarian cancer30.8BRCA1, BRCA2
5cervical cancer30.7MUC16
6adenocarcinoma30.7CDH1, MUC16, CTNNB1, BRCA2, BRCA1
7fallopian tube cancer30.6BRCA2, BRCA1
8colon cancer30.6BRCA1, BRCA2, CTNNB1, CDH1
9lynch syndrome30.5BRCA1, BRCA2
10endometrial carcinoma30.2BRCA1, BRCA2, CTNNB1, MUC16, CDH1
11papillary carcinoma30.2BRCA2, MUC16, CDH1
12male breast cancer30.2BRCA2, BRCA1
13breast-ovarian cancer, familial, 230.2BRCA2
14ovarian cystadenoma30.0BRCA1, MUC16
15meigs syndrome30.0MUC16
16leiomyosarcoma29.8MUC16
17stomach cancer29.8CDH1
18hereditary breast ovarian cancer10.9
19endodermal sinus tumor10.9
20leydig cell tumor10.8
21vascular cancer10.8
22sertoli cell tumor10.8
23ovarian disease10.8
24sertoli-leydig cell tumor10.7
25cell type cancer10.7
26ovarian endometriosis10.6
27colorectal cancer10.6
28lung cancer10.6
29prostate cancer10.5
30prostatitis10.5
31primitive neuroectodermal tumor10.5
32ovarian cyst10.5
33sporadic breast cancer10.5
34cervicitis10.5
35lymph node cancer10.5
36thrombocytosis10.4
37adenomatoid tumor10.4
38ovarian small cell carcinoma10.4
39small cell carcinoma10.3
40ovarian brenner tumor10.3
41amenorrhea10.3
42dysgerminoma of ovary10.3
43glomus tumor10.3
44peripheral primitive neuroectodermal tumor10.3
45ovarian lymphoma10.3
46breast disease10.3
47pelvic inflammatory disease10.3
48ovarian cancer, somatic10.3
49clear cell adenocarcinoma10.2
50ovarian clear cell adenocarcinoma10.2

Graphical network of the top 20 diseases related to Ovarian Cancer:



Diseases related to ovarian cancer

Clinical Features for Ovarian Cancer

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46OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Ovarian Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Ovarian Cancer

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22GTR
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Genetic tests related to Ovarian Cancer:

id Genetic test Affiliating Genes
1 Neoplasm of Ovary22

Anatomical Context for Ovarian Cancer

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32MalaCards
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MalaCards organs/tissues related to Ovarian Cancer:

32
Breast, Ovary, Testes, Endothelial, Prostate, Lung, T cells, Colon, Lymph node, Bone, Thyroid, Monocytes, Testis, Bone marrow, Pituitary, Brain, Appendix, Heart, Liver, Nk cells, Cervix, Smooth muscle, Myeloid, Uterus, Spleen, Eye, Cortex

Animal Models for Ovarian Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.3EEF1A2, BRCA1, CTNNB1, GPR68, BRCA2, RRAS2
2MP:000200612.1BRCA1, BRCA2, CTNNB1, BARD1, DPH1, CDH1
3MP:000538012.0TSHZ2, BRCA1, BRCA2, CTNNB1, BARD1, CDH1

Publications for Ovarian Cancer

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50PubMed
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Articles related to Ovarian Cancer:

(show top 50)    (show all 5285)
idTitleAuthorsYear
1
Discrete molecular classes of ovarian cancer suggestive of unique mechanisms of transformation and metastases. (24132919)
2014
2
Cost-effectiveness of early-initiated treatment for advanced-stage epithelial ovarian cancer patients: a modeling study. (24362714)
2014
3
Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer. (23147994)
2013
4
Paraneoplastic cerebellar degeneration associated with ovarian cancer. (23420048)
2013
5
Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells. (22508482)
2013
6
Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study. (22958293)
2012
7
The endothelin A receptor and epidermal growth factor receptor signaling converge on I^-catenin to promote ovarian cancer metastasis. (22480520)
2012
8
Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer -a study of the OVCAD consortium. (22978347)
2012
9
Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. (21753153)
2011
10
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (20852632)
2010
11
Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors. (19376514)
2010
12
Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin. (19647363)
2010
13
Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity. (19415457)
2009
14
An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. (19567818)
2009
15
Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. (18187487)
2008
16
The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (17544200)
2008
17
Luteinizing hormone-induced up-regulation of ErbB-2 is insufficient stimulant of growth and invasion in ovarian cancer cells. (19010824)
2008
18
Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance. (18506185)
2008
19
Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells. (18337445)
2008
20
Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer. (17962725)
2007
21
Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines. (17269733)
2007
22
Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression. (17459055)
2007
23
Critical involvement of ILK in TGFbeta1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system. (17187779)
2007
24
Long-term survival after paclitaxel plus platinum-based combination chemotherapy for extraovarian peritoneal serous papillary carcinoma: is it different from that for ovarian serous papillary cancer? (16681715)
2006
25
Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner. (16545436)
2006
26
A distinct molecular profile associated with mucinous epithelial ovarian cancer. (16508639)
2006
27
Evaluation of the prognostic value of cellular inhibitor of apoptosis protein in epithelial ovarian cancer using automated quantitative protein analysis. (16775178)
2006
28
Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. (15557783)
2004
29
Id-I stimulates cell proliferation through activation of EGFR in ovarian cancer cells. (15599381)
2004
30
Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (14722926)
2004
31
Study of the effect of TF/FVIIa complex on the expression of u-PAR mRNA in human ovarian cancer]. (15182581)
2004
32
nhibitory effect of adenosine analogues on invasion of human ovarian cancer cell line HO-8910PM]. (15601553)
2004
33
Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. (15305371)
2004
34
Expression of angiogenesis factors in monolayer culture, multicellular spheroid and in vivo transplanted tumor by human ovarian cancer cell lines. (12860281)
2003
35
Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. (12431046)
2002
36
Interpretation of sequential measurements of cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer. (11506467)
2001
37
Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells. (11331280)
2001
38
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. (11103784)
2000
39
Luteinizing hormone-releasing hormone as an autocrine growth factor in ES-2 ovarian cancer cell line. (10762638)
2000
40
In vitro activity of human chorionic gonadotropin (hCG)--doxorubicin conjugates against ovarian cancer cells. (11062714)
2000
41
Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line. (10692490)
2000
42
Sensitivity to paclitaxel is not related to p53-dependent apoptosis in ovarian cancer cells. (10974635)
2000
43
Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro. (10366461)
1999
44
Thymidine phosphorylase activity and prodrug effects in a three-dimensional model of angiogenesis: implications for the treatment of ovarian cancer. (9811349)
1998
45
Mutations of p53 gene exons 5 to 8 in human ovarian cancer and its clinical significance]. (9387525)
1996
46
Expression of glutathione S-transferase-pi in human ovarian cancer as an indicator of resistance to chemotherapy. (8157188)
1994
47
Paclitaxel (Taxol) treatment for refractory ovarian cancer: phase II clinical trial. (7911273)
1994
48
Serum albumin and CA125 are powerful predictors of survival in epithelial ovarian cancer. (7999691)
1994
49
p53 expression, mutation, and allelic deletion in ovarian cancer. (7823248)
1994
50
The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer. (7507078)
1993

Genetic Variations for Ovarian Cancer

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Expression for genes affiliated with Ovarian Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer

Search GEO for disease gene expression data for Ovarian Cancer.

Pathways for genes affiliated with Ovarian Cancer

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37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Ovarian Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Ovarian Cancer according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1estrogen4412.0BRCA1, BRCA2, CTNNB1, BARD1, MUC16, CDH1
2paclitaxel44 49 1113.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
3paraffin4411.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
4cisplatin44 49 59 1114.9BRCA1, BRCA2, CTNNB1, MUC16, CDH1
5progesterone44 59 28 11 2415.7BRCA1, BRCA2, CTNNB1, MUC16, CDH1
6indole-3-carbinol4411.7CDH1, CTNNB1, BRCA2, BRCA1
7p0024411.7BRCA1, BRCA2, CTNNB1, CDH1
8testosterone44 59 11 2414.6BRCA1, BRCA2, CTNNB1, MUC16, CDH1
9agar4411.6BRCA1, CTNNB1, CDH1, RRAS2
10tamoxifen44 49 28 1114.5BRCA1, BRCA2, CTNNB1, CDH1
11sodium bisulfite4411.5CDH1, CTNNB1, BRCA1
12leptomycin b44 5912.4CDH1, CTNNB1, BRCA1
134-hydroxytamoxifen4411.4CTNNB1, BRCA2, BRCA1
14bleomycin44 1112.3BRCA1, BRCA2, CTNNB1
15adpribose4411.3CTNNB1, BRCA2, BRCA1
16nocodazole44 1112.2BRCA1, CTNNB1, CDH1
17chlorophyllin4411.2CDH1, CTNNB1
18cyclopamine44 5912.1CTNNB1, CDH1
19p0034411.1CDH1, BRCA2, BRCA1
20resveratrol44 59 11 2414.1CTNNB1, BRCA2, BRCA1
21doxorubicin44 49 1113.0CDH1, MUC16, CTNNB1, BRCA1
22adriamycin4411.0CTNNB1
23exisulind4410.8CTNNB1, CDH1

GO Terms for genes affiliated with Ovarian Cancer

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16Gene Ontology
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Cellular components related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-A complexGO:07053110.9BARD1, BRCA1
2BRCA1-BARD1 complexGO:03143610.8BARD1, BRCA1
3catenin complexGO:01634210.6CDH1, CTNNB1

Biological processes related to Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168111.1CDH1, CTNNB1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.9BRCA2, BRCA1
3regulation of protein localization to cell surfaceGO:200000810.8CDH1, CTNNB1
4protein K6-linked ubiquitinationGO:08502010.6BARD1, BRCA1

Products for genes affiliated with Ovarian Cancer

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  • Antibodies
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  • Lysates
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Sources for Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet