MCID: OVR078
MIFTS: 65

Ovarian Cancer, Somatic malady

Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases categories

Summaries for Ovarian Cancer, Somatic

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MedlinePlus:32 The ovaries are part of the female reproductive system. they produce a woman's eggs and female hormones. each ovary is about the size and shape of an almond. cancer of the ovary is not common, but it causes more deaths than other female reproductive cancers. the sooner ovarian cancer is found and treated, the better your chance for recovery. but ovarian cancer is hard to detect early. women with ovarian cancer may have no symptoms or just mild symptoms until the disease is in an advanced stage. then it is hard to treat. symptoms may include a heavy feeling in the pelvis pain in the lower abdomen bleeding from the vagina weight gain or loss abnormal periods unexplained back pain that gets worse gas, nausea, vomiting, or loss of appetite to diagnose ovarian cancer, doctors do one or more tests. they include a physical exam, a pelvic exam, lab tests, ultrasound, or a biopsy. treatment is usually surgery followed by chemotherapy. nih: national cancer institute

MalaCards based summary: Ovarian Cancer, Somatic, also known as ovarian cancer, is related to breast cancer and fallopian tube cancer, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and breast carcinoma. An important gene associated with Ovarian Cancer, Somatic is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Adherens junction and Nectin adhesion pathway. The drugs cyclophosphamide and doxorubicin hydrochloride liposome and the compounds sodium bisulfite and everolimus have been mentioned in the context of this disorder. Affiliated tissues include the ovary, ovary and testes, and related mouse phenotypes are no phenotypic analysis and skeleton.

Disease Ontology:9 A female reproductive organ cancer that is located in the ovary.

CDC:3 Cancer is a disease in which cells in the body grow out of control. Cancer is always named for the part of the body where it starts, even if it spreads to other body parts later.

OMIM:45 Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with... (167000) more...

Aliases & Classifications for Ovarian Cancer, Somatic

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Ovarian Cancer, Somatic, Aliases & Descriptions:

Name: Ovarian Cancer, Somatic 45 10
Ovarian Cancer 9 41 11 43 32 3
Ovarian Carcinoma 9 41 43 60
Adenocarcinoma, Ovarian, Somatic 45 10
Ovarian Neoplasm 9 60
Ovary Neoplasm 9 22
Ovarian Cancer Ovarian Cancer, Epithelial, Included 45
Primary Malignant Neoplasm of Ovary 60
 
Ovarian Cancer, Susceptibility to 10
Malignant Neoplasm of Ovary 60
Ovarian Carcinoma, Somatic 45
Malignant Tumour of Ovary 9
Epithelial Ovarian Cancer 60
Malignant Ovarian Tumor 9
Primary Ovarian Cancer 9
Tumor of the Ovary 9


Classifications:



Related Diseases for Ovarian Cancer, Somatic

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Diseases related to Ovarian Cancer, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 344)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.6ERBB2, BRCA1
2fallopian tube cancer31.2BRCA1
3malignant mixed mullerian tumor31.0ERBB2, KRAS, CTNNB1
4lynch syndrome30.9BRCA1, KRAS
5pancreatic cancer30.4CDH1, KRAS, AKT1
6li-fraumeni syndrome30.4BRCA1, ERBB2
7prostate cancer30.4AKT1, ERBB2, CDH1, CTNNB1
8colorectal cancer30.4CTNNB1, CDH1, KRAS, AKT1, PIK3CA
9cystadenoma30.3BRCA1, KRAS
10lung cancer30.2KRAS, ERBB2, PIK3CA
11endometrial cancer30.2ERBB2, KRAS, CDH1, CTNNB1
12cowden disease30.2BRCA1, PIK3CA
13colon adenocarcinoma30.1KRAS, CDH1, CTNNB1
14melanoma29.9PIK3CA, AKT1, KRAS, CDH1, CTNNB1
15adenocarcinoma29.9PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
16adenomatous polyposis coli29.9BRCA1, KRAS, CDH1, CTNNB1
17leukemia29.8KRAS, AKT1, PARK2, BRCA1, PIK3CA
18adenoma29.8CTNNB1, CDH1, KRAS, BRCA1
19retinoblastoma29.4PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
20endodermal sinus tumor10.9
21hereditary breast ovarian cancer10.9
22peritonitis10.9
23endotheliitis10.9
24hypoxia10.7
25endometriosis10.7
26mixed germ cell tumor10.7
27prostatitis10.6
28brca2 hereditary breast and ovarian cancer10.6
29neuroectodermal tumor10.6
30sertoli cell tumor10.6
31cervicitis10.5
32thrombocytosis10.5
33brca1 hereditary breast and ovarian cancer10.5
34gastric cancer risk after h. pylori infection10.5CDH1
35adenomatoid tumor10.5
36insulin-like growth factor i10.5
37mesothelioma10.5
38ovarian cyst10.4
39peritoneal carcinoma10.4
40cerebellar degeneration10.4
41paraneoplastic cerebellar degeneration10.4
42primary peritoneal carcinoma10.4
43goblet cell carcinoid10.4CDH1, CTNNB1
44ovarian brenner tumor10.4
45fibroma10.4
46amenorrhea10.4
47glomus tumor10.4
48peripheral primitive neuroectodermal tumor10.4
49malignant mixed epithelial mesenchymal tumor of the ovary10.4
50breast-ovarian cancer, familial, 210.3

Graphical network of the top 20 diseases related to Ovarian Cancer, Somatic:



Diseases related to ovarian cancer, somatic

Symptoms for Ovarian Cancer, Somatic

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Symptoms by clinical synopsis from OMIM:

167000

Clinical features from OMIM:

167000

HPO human phenotypes related to Ovarian Cancer, Somatic:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 breast carcinoma HP:0003002
4 ovarian papillary adenocarcinoma HP:0006774
5 dysgerminoma HP:0100621

Drugs & Therapeutics for Ovarian Cancer, Somatic

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Genetic Tests for Ovarian Cancer, Somatic

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Genetic tests related to Ovarian Cancer, Somatic:

id Genetic test Affiliating Genes
1 Neoplasm of Ovary22

Anatomical Context for Ovarian Cancer, Somatic

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MalaCards organs/tissues related to Ovarian Cancer, Somatic:

31
Ovary, Testes, Breast

FMA organs/tissues related to Ovarian Cancer, Somatic:

14
The ovary

Animal Models for Ovarian Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Cancer, Somatic:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7PIK3CA, PARK2, OPCML, CDH1, CTNNB1
2MP:00053908.5CTNNB1, ERBB2, AKT1, PARK2, BRCA1
3MP:00053818.4BRCA1, ERBB2, KRAS, CDH1, CTNNB1
4MP:00053718.3BRCA1, PALB2, ERBB2, KRAS, CTNNB1
5MP:00053888.2BRCA1, PARK2, AKT1, ERBB2, KRAS, CTNNB1
6MP:00028738.2BRCA1, AKT1, ERBB2, KRAS, CDH1, CTNNB1
7MP:00053758.0PIK3CA, RRAS2, BRCA1, AKT1
8MP:00053798.0PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
9MP:00053897.9PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
10MP:00053697.9PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
11MP:00053867.7PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
12MP:00053767.5PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
13MP:00053807.4PIK3CA, BRCA1, PALB2, AKT1, ERBB2, KRAS
14MP:00053877.3PIK3CA, RRAS2, BRCA1, AKT1, KRAS, CDH1
15MP:00036317.2PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
16MP:00107717.0PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
17MP:00053846.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
18MP:00107686.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
19MP:00020066.6CTNNB1, PIK3CA, RRAS2, BRCA1, PALB2, AKT1
20MP:00053856.2PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1
21MP:00053786.1PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1

Publications for Ovarian Cancer, Somatic

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Variations for Ovarian Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Ovarian Cancer, Somatic:

62
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421
7PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Ovarian Cancer, Somatic:

6 (show all 34)
id Gene Variation Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
3PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
4PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
5ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
6AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
7NC_012920.1: m.14743A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14743: 14743
8MT-CYBNC_012920.1: m.14753C> Tsingle nucleotide variantLikely pathogenicGRCh38Chr MT, 14753: 14753
9MT-CYBNC_012920.1: m.14784T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14784: 14784
10MT-CYBNC_012920.1: m.15058C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15058: 15058
11MT-CYBNC_012920.1: m.15098A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15098: 15098
12MT-CYBNC_012920.1: m.15314G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15314: 15314
13MT-CYBNC_012920.1: m.15328A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15328: 15328
14MT-CYBNC_012920.1: m.15334C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15334: 15334
15MT-CYBNC_012920.1: m.15363A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15363: 15363
16MT-CYBNC_012920.1: m.15453T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15453: 15453
17MT-CYBNC_012920.1: m.15459C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15459: 15459
18MT-CYBNC_012920.1: m.15511T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15511: 15511
19MT-CYBNC_012920.1: m.15884G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15884: 15884
20MT-TTNC_012920.1: m.15890C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15890: 15890
21MT-TTNC_012920.1: m.15928G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15928: 15928
22MT-TTNC_012920.1: m.15932T> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15932: 15932
23MT-TTNC_012920.1: m.15943T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15943: 15943
24MT-CYBNC_012920.1: m.15061A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15061: 15061
25MT-CYBNC_012920.1: m.15148G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15148: 15148
26MT-CYBNC_012920.1: m.15259C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15259: 15259
27MT-CYBNC_012920.1: m.15431G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15431: 15431
28MT-CYBNC_012920.1: m.15452C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15452: 15452
29MT-CYBNC_012920.1: m.15607A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15607: 15607
30MT-CYBNC_012920.1: m.15670T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15670: 15670
31CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
32PARK2PARK2, DELdeletionPathogenic
33OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
34RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Cosmic variations for Ovarian Cancer, Somatic:

7 (show all 28)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
153264EGFRovary,NS,carcinoma,adenocarcinoma3
253227EGFRovary,NS,carcinoma,adenocarcinoma3
353213EGFRovary,NS,carcinoma,adenocarcinoma3
428286EGFRovary,NS,carcinoma,adenocarcinoma3
553228EGFRovary,NS,carcinoma,adenocarcinoma3
653232EGFRovary,NS,carcinoma,adenocarcinoma3
722992EGFRovary,NS,carcinoma,adenocarcinoma3
853230EGFRovary,NS,carcinoma,adenocarcinoma3
928511EGFRovary,NS,carcinoma,adenocarcinoma3
106224EGFRovary,NS,carcinoma,adenocarcinoma3
1153224EGFRovary,NS,carcinoma,adenocarcinoma3
1253226EGFRovary,NS,carcinoma,adenocarcinoma3
1353265EGFRovary,NS,carcinoma,adenocarcinoma3
1412373EGFRovary,NS,carcinoma,adenocarcinoma3
1553266EGFRovary,NS,carcinoma,adenocarcinoma3
16775PIK3CAovary,NS,carcinoma,adenocarcinoma3
17760PIK3CAovary,NS,carcinoma,adenocarcinoma3
181668065INSRRovary,NS,carcinoma,adenocarcinoma3
19727028EP300ovary,NS,carcinoma,adenocarcinoma3
201674106CSMD3ovary,NS,carcinoma,adenocarcinoma3
2130798CTNNB1ovary,NS,carcinoma,adenocarcinoma3
221682212LIMK2ovary,NS,carcinoma,adenocarcinoma3
231677803ING1ovary,NS,carcinoma,adenocarcinoma3
241669397LRP2ovary,NS,carcinoma,adenocarcinoma3
2510662TP53ovary,NS,carcinoma,adenocarcinoma3
261681052RAB4Bovary,NS,carcinoma,adenocarcinoma3
271680748NOTCH3ovary,NS,carcinoma,adenocarcinoma3
281669654ORC2ovary,NS,carcinoma,adenocarcinoma3

Expression for genes affiliated with Ovarian Cancer, Somatic

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Search GEO for disease gene expression data for Ovarian Cancer, Somatic.

Pathways for genes affiliated with Ovarian Cancer, Somatic

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Pathways related to Ovarian Cancer, Somatic according to GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ERBB2, CDH1, CTNNB1
29.4CTNNB1, PIK3CA, CDH1
39.4CTNNB1, CDH1, KRAS
4
Show member pathways
VEGFR1 specific signals36
9.4PIK3CA, CTNNB1, AKT1
59.3PIK3CA, AKT1, CDH1
69.3CDH1, AKT1, PIK3CA
7
Show member pathways
9.3ERBB2, AKT1, PIK3CA
89.3AKT1, KRAS, CTNNB1
99.3BRCA1, AKT1, CTNNB1
109.2AKT1, KRAS, ERBB2
119.2CTNNB1, ERBB2, AKT1, CDH1
129.1KRAS, PIK3CA, AKT1
13
Show member pathways
9.1AKT1, KRAS, PIK3CA
14
Show member pathways
IFN-gamma pathway36
9.1AKT1, BRCA1, PIK3CA
15
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.1AKT1, PIK3CA, BRCA1
169.1PIK3CA, CDH1, CTNNB1, AKT1
179.1CTNNB1, CDH1, AKT1, PIK3CA
18
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.0PIK3CA, AKT1, ERBB2, CTNNB1
199.0CDH1, AKT1, ERBB2, PIK3CA
208.8CTNNB1, KRAS, AKT1, PIK3CA
21
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.8PIK3CA, KRAS, CTNNB1, AKT1
22
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.8KRAS, ERBB2, AKT1, PIK3CA
23
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
8.8ERBB2, KRAS, PIK3CA, AKT1
24
Show member pathways
8.8ERBB2, AKT1, PIK3CA, KRAS
25
Show member pathways
8.8KRAS, ERBB2, PIK3CA, AKT1
26
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.8PIK3CA, AKT1, ERBB2, KRAS
27
Show member pathways
8.8PIK3CA, AKT1, ERBB2, KRAS
28
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.8AKT1, PIK3CA, ERBB2, KRAS
29
Show member pathways
8.7CTNNB1, CDH1, AKT1, RRAS2
308.7CTNNB1, RRAS2, AKT1, CDH1
318.6KRAS, ERBB2, BRCA1, PIK3CA
32
Show member pathways
8.5KRAS, PIK3CA, AKT1, ERBB2, CTNNB1
33
Show member pathways
8.5CTNNB1, KRAS, RRAS2, AKT1
348.5AKT1, KRAS, CTNNB1, RRAS2
358.5CTNNB1, KRAS, BRCA1, AKT1, CDH1
36
Show member pathways
8.4CDH1, ERBB2, AKT1, RRAS2, CTNNB1
37
Show member pathways
8.4RRAS2, CTNNB1, CDH1, ERBB2, AKT1
38
Show member pathways
8.3KRAS, PIK3CA, AKT1, RRAS2
39
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.2PIK3CA, AKT1, ERBB2, CTNNB1, RRAS2
408.2CDH1, PIK3CA, AKT1, KRAS, ERBB2, CTNNB1
41
Show member pathways
Signal transduction PTEN pathway58
8.2CTNNB1, CDH1, KRAS, ERBB2, PIK3CA, AKT1
42
Show member pathways
8.1AKT1, CDH1, RRAS2, BRCA1, ERBB2
438.0PIK3CA, RRAS2, AKT1, KRAS, CTNNB1
448.0BRCA1, PIK3CA, AKT1, ERBB2, CTNNB1, KRAS
45
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
7.9CTNNB1, PIK3CA, CDH1, ERBB2, AKT1, RRAS2
46
Show member pathways
7.8RRAS2, AKT1, ERBB2, CDH1, BRCA1, CTNNB1
47
Show member pathways
7.7CTNNB1, PIK3CA, RRAS2, AKT1, KRAS, CDH1
487.7PIK3CA, RRAS2, CTNNB1, KRAS, ERBB2, AKT1
49
Show member pathways
Signaling Pathways in Glioblastoma36
7.7BRCA1, PIK3CA, AKT1, ERBB2, KRAS, CDH1
50
Show member pathways
7.5CDH1, PIK3CA, BRCA1, PARK2, AKT1, KRAS

Compounds for genes affiliated with Ovarian Cancer, Somatic

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Compounds related to Ovarian Cancer, Somatic according to GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite439.7BRCA1, CDH1, CTNNB1
2everolimus43 49 1211.6PIK3CA, AKT1, ERBB2
3celecoxib43 59 28 49 24 1214.5AKT1, ERBB2, CDH1, CTNNB1
4geldanamycin43 49 59 1212.5PARK2, ERBB2, CDH1, CTNNB1
5indole-3-carbinol439.4BRCA1, AKT1, CDH1, CTNNB1
6ag 1478439.3CTNNB1, ERBB2, AKT1, PIK3CA
7herbimycin a43 5910.3CTNNB1, CDH1, ERBB2, AKT1
8crcs439.3PIK3CA, KRAS, CDH1, CTNNB1
9nocodazole43 1210.3CTNNB1, CDH1, AKT1, BRCA1
104-hydroxytamoxifen439.3CTNNB1, ERBB2, AKT1, BRCA1
11egcg439.3CTNNB1, CDH1, ERBB2, PIK3CA
12cetuximab43 49 1211.2ERBB2, KRAS, CTNNB1
13erlotinib43 49 1211.2CDH1, KRAS, ERBB2, PIK3CA
14curcumin439.2CTNNB1, CDH1, ERBB2, AKT1
1517-(allylamino)-17-demethoxygeldanamycin439.2CDH1, ERBB2, AKT1
16resveratrol43 59 24 1212.1CTNNB1, ERBB2, BRCA1, PIK3CA
17docetaxel43 49 59 1212.1PIK3CA, BRCA1, ERBB2, CDH1
18adriamycin439.1BRCA1, AKT1, ERBB2, CDH1, CTNNB1
19mg 13243 5910.0BRCA1, PARK2, AKT1, CDH1, CTNNB1
20glycogen43 249.9CTNNB1, CDH1, AKT1, PARK2, PIK3CA
21imatinib43 49 1210.9PIK3CA, ERBB2, KRAS, CTNNB1
22p002438.9BRCA1, ERBB2, KRAS, CDH1, CTNNB1
23phosphotyrosine438.9PIK3CA, BRCA1, ERBB2, CDH1, CTNNB1
24guanine43 24 1210.9BRCA1, PARK2, AKT1, ERBB2, CTNNB1
25etoposide43 49 59 1211.8CDH1, ERBB2, AKT1, BRCA1, PIK3CA
26glutamine438.8BRCA1, PARK2, AKT1, CDH1, CTNNB1
27phosphoinositide438.7PIK3CA, PARK2, AKT1, KRAS, CTNNB1
28gefitinib43 49 1210.6PIK3CA, AKT1, ERBB2, KRAS, CDH1, CTNNB1
29tamoxifen43 49 28 1211.6PIK3CA, BRCA1, AKT1, ERBB2, CDH1, CTNNB1
30rapamycin438.6PIK3CA, AKT1, ERBB2, KRAS, CDH1, CTNNB1
31ly294002438.6PIK3CA, AKT1, ERBB2, KRAS, CDH1, CTNNB1
32wortmannin438.6PIK3CA, AKT1, ERBB2, KRAS, CDH1, CTNNB1
33doxorubicin43 49 1210.6PIK3CA, BRCA1, AKT1, ERBB2, CDH1, CTNNB1
34genistein43 28 59 2 24 1213.6PIK3CA, BRCA1, AKT1, ERBB2, CDH1, CTNNB1
35progesterone43 28 59 24 1212.6CTNNB1, CDH1, ERBB2, BRCA1, PIK3CA
36paraffin438.5BRCA1, AKT1, ERBB2, KRAS, CDH1, CTNNB1
37alanine438.5CTNNB1, CDH1, ERBB2, AKT1, PARK2, BRCA1
385fluorouracil438.5PIK3CA, BRCA1, ERBB2, KRAS, CDH1, CTNNB1
39testosterone43 59 24 1211.2PIK3CA, BRCA1, PARK2, AKT1, ERBB2, CDH1
40retinoic acid43 249.1PIK3CA, BRCA1, AKT1, KRAS, CDH1, CTNNB1
41cisplatin43 49 59 1211.1PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
42phosphatidylinositol438.1PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
43h2o2438.0PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
44gtp43 289.0PIK3CA, RRAS2, PARK2, AKT1, KRAS, CTNNB1
45agar437.8PIK3CA, RRAS2, BRCA1, AKT1, ERBB2, CDH1
46paclitaxel43 49 129.7CTNNB1, PIK3CA, BRCA1, PARK2, AKT1, ERBB2
47vegf437.7PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
48estrogen437.7PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
49serine436.9PIK3CA, RRAS2, BRCA1, PARK2, AKT1, ERBB2
50tyrosine436.9PIK3CA, RRAS2, BRCA1, PARK2, AKT1, ERBB2

GO Terms for genes affiliated with Ovarian Cancer, Somatic

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Cellular components related to Ovarian Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:001634210.0CTNNB1, CDH1
2lateral plasma membraneGO:00163289.9CTNNB1, CDH1
3cell-cell adherens junctionGO:00059139.8CTNNB1, CDH1
4aggresomeGO:00162359.8PARK2, CDH1
5basolateral plasma membraneGO:00163239.6CTNNB1, CDH1, ERBB2
6cytoplasmic side of plasma membraneGO:00098989.6CTNNB1, CDH1
7perinuclear region of cytoplasmGO:00484719.3PARK2, ERBB2, CDH1, CTNNB1
8plasma membraneGO:00058866.7CTNNB1, PIK3CA, RRAS2, BRCA1, AKT1, ERBB2

Biological processes related to Ovarian Cancer, Somatic according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:0200000810.2CDH1, CTNNB1
2regulation of angiogenesisGO:004576510.0CTNNB1, ERBB2
3negative regulation of release of cytochrome c from mitochondriaGO:00902019.9AKT1, PARK2
4striated muscle cell differentiationGO:00511469.8KRAS, AKT1
5positive regulation of nitric-oxide synthase activityGO:00510009.8AKT1, KRAS
6cellular response to indole-3-methanolGO:00716819.7CTNNB1, CDH1, BRCA1
7protein kinase B signalingGO:00434919.7AKT1, PIK3CA
8positive regulation of MAP kinase activityGO:00434069.6KRAS, ERBB2
9protein autoubiquitinationGO:00518659.5BRCA1, PARK2
10phosphatidylinositol-mediated signalingGO:00480159.5ERBB2, AKT1, PIK3CA
11positive regulation of protein phosphorylationGO:00019349.5KRAS, ERBB2, AKT1
12androgen receptor signaling pathwayGO:00305219.4CTNNB1, BRCA1
13negative regulation of neuron apoptotic processGO:00435249.4PIK3CA, PARK2, KRAS
14insulin receptor signaling pathwayGO:00082869.3KRAS, AKT1, PIK3CA
15apoptotic processGO:00069159.1BRCA1, AKT1, CDH1, CTNNB1
16fibroblast growth factor receptor signaling pathwayGO:00085439.1KRAS, ERBB2, AKT1, PIK3CA
17Fc-epsilon receptor signaling pathwayGO:00380959.1PIK3CA, AKT1, ERBB2, KRAS
18epidermal growth factor receptor signaling pathwayGO:00071739.1KRAS, ERBB2, AKT1, PIK3CA
19neurotrophin TRK receptor signaling pathwayGO:00480119.1KRAS, ERBB2, AKT1, PIK3CA
20protein ubiquitinationGO:00165679.1AKT1, PARK2, BRCA1
21innate immune responseGO:00450878.8PIK3CA, AKT1, ERBB2, KRAS, CTNNB1

Molecular functions related to Ovarian Cancer, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase bindingGO:00199009.8CTNNB1, PARK2
2protein phosphatase bindingGO:00199039.6ERBB2, CDH1, CTNNB1
3androgen receptor bindingGO:00506819.6BRCA1, CTNNB1
4kinase activityGO:00163019.3PIK3CA, AKT1
5enzyme bindingGO:00198999.3CTNNB1, AKT1, BRCA1
6protein bindingGO:00055155.9CTNNB1, PIK3CA, RRAS2, BRCA1, PARK2, PALB2

Products for genes affiliated with Ovarian Cancer, Somatic

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  • Antibodies
  • Proteins
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  • Kits and Assays

Sources for Ovarian Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet