MCID: OVR078
MIFTS: 45

Ovarian Cancer, Somatic malady

Genetic diseases (common), Cancer diseases categories

Summaries for Ovarian Cancer, Somatic

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OMIM:46 Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with...167000 more...

MalaCards based summary: Ovarian Cancer, Somatic, also known as ovarian carcinoma, somatic, is related to ovarian cancer and hereditary diffuse gastric cancer, and has symptoms including autosomal dominant inheritance, abnormality of metabolism/homeostasis and breast carcinoma. An important gene associated with Ovarian Cancer, Somatic is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Adherens junction and Nectin adhesion pathway. The compounds sodium bisulfite and everolimus have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and limbs/digits/tail.

Aliases & Classifications for Ovarian Cancer, Somatic

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Ovarian Cancer, Somatic, Aliases & Descriptions:

Name: Ovarian Cancer, Somatic 46
 
Ovarian Carcinoma, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Related Diseases for Ovarian Cancer, Somatic

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Diseases related to Ovarian Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer29.9PIK3CA, BRCA1, ERBB2, KRAS, CDH1, CTNNB1
2hereditary diffuse gastric cancer10.5CDH1
3fallopian tube cancer10.4BRCA1
4goblet cell carcinoid10.4CDH1, CTNNB1
5hepatocellular carcinoma, somatic10.3CTNNB1, PIK3CA
6inflammatory breast carcinoma10.3ERBB2, CDH1
7stomach cancer10.3CDH1, ERBB2
8breast cancer, somatic10.3PIK3CA, KRAS
9tubular adenocarcinoma10.2ERBB2, CDH1, CTNNB1
10breast cancer10.2BRCA1, AKT1
11bronchiolo-alveolar adenocarcinoma10.2KRAS, CDH1
12male breast cancer10.2ERBB2, BRCA1
13salivary gland adenoid cystic carcinoma10.2CDH1, ERBB2
14adenocarcinoma of lung, somatic10.2PARK2, ERBB2
15thyroid cancer, anaplastic10.2PIK3CA, CDH1, CTNNB1
16autosomal dominant disease10.2BRCA1, AKT1
17colorectal cancer, somatic10.2PIK3CA, AKT1, CTNNB1
18bladder carcinoma in situ10.2ERBB2, CDH1
19malignant mixed mullerian tumor10.2ERBB2, KRAS, CTNNB1
20large cell carcinoma10.2KRAS, ERBB2
21cowden disease10.2BRCA1, PIK3CA
22synovial sarcoma10.2CTNNB1, CDH1
23li-fraumeni syndrome10.2BRCA1, ERBB2
24colon adenocarcinoma10.2KRAS, CDH1, CTNNB1
25cystadenoma10.2BRCA1, KRAS
26lynch syndrome10.2BRCA1, KRAS
27factor vii deficiency10.1ERBB2, KRAS
28breast cancer, invasive ductal10.1BRCA1, ERBB2, CDH1
29ductal carcinoma in situ10.1CDH1, ERBB2, BRCA1
30breast ductal carcinoma10.1CDH1, ERBB2, BRCA1
31fanconi's anemia10.1BRCA1, PARK2
32gastric cancer, somatic10.1KRAS, ERBB2, PIK3CA
33squamous cell carcinoma of the head and neck10.1CDH1, ERBB2, PIK3CA
34pancreatic cancer10.1CDH1, KRAS, AKT1
35prostate cancer10.1AKT1, ERBB2, CDH1, CTNNB1
36endometrial carcinoma10.1ERBB2, KRAS, CDH1, CTNNB1
37medulloblastoma10.0CTNNB1, ERBB2, AKT1, PIK3CA
38cholangiocarcinoma10.0CDH1, KRAS, ERBB2, PIK3CA
39familial adenomatous polyposis10.0BRCA1, KRAS, CDH1, CTNNB1
40lung cancer9.9KRAS, ERBB2, PIK3CA
41adenoma9.9CTNNB1, CDH1, KRAS, BRCA1
42gastric adenocarcinoma9.9PIK3CA, ERBB2, KRAS, CDH1, CTNNB1
43kidney cancer9.9CDH1, AKT1, PARK2, PIK3CA
44aplastic anemia9.9BRCA1, PALB2
45colorectal cancer9.9PIK3CA, ERBB2, KRAS, CDH1, CTNNB1
46colonic benign neoplasm9.9CTNNB1, CDH1, KRAS, AKT1, PIK3CA
47melanoma9.8PIK3CA, AKT1, KRAS, CDH1, CTNNB1
48astrocytoma9.8AKT1, PARK2, BRCA1, PIK3CA
49bladder carcinoma9.8PIK3CA, BRCA1, ERBB2, KRAS, CDH1
50burkitt's lymphoma9.7PIK3CA, PARK2, AKT1, KRAS

Graphical network of the top 20 diseases related to Ovarian Cancer, Somatic:



Diseases related to ovarian cancer, somatic

Symptoms for Ovarian Cancer, Somatic

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Symptoms by clinical synopsis from OMIM:

167000

Clinical features from OMIM:

167000

HPO human phenotypes related to Ovarian Cancer, Somatic:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of metabolism/homeostasis HP:0001939
3 breast carcinoma HP:0003002
4 ovarian papillary adenocarcinoma HP:0006774
5 dysgerminoma HP:0100621

Drugs & Therapeutics for Ovarian Cancer, Somatic

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Drug clinical trials:

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Search NIH Clinical Center for Ovarian Cancer, Somatic

Genetic Tests for Ovarian Cancer, Somatic

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Anatomical Context for Ovarian Cancer, Somatic

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Animal Models for Ovarian Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Cancer, Somatic:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.5PIK3CA, PARK2, OPCML, CDH1, CTNNB1
2MP:00053718.5BRCA1, PALB2, ERBB2, KRAS, CTNNB1
3MP:00053818.5BRCA1, ERBB2, KRAS, CDH1, CTNNB1
4MP:00053908.3CTNNB1, ERBB2, AKT1, PARK2, BRCA1
5MP:00028738.3BRCA1, AKT1, ERBB2, KRAS, CDH1, CTNNB1
6MP:00053888.1BRCA1, PARK2, AKT1, ERBB2, KRAS, CTNNB1
7MP:00053798.1PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
8MP:00053758.0PIK3CA, RRAS2, BRCA1, AKT1
9MP:00053898.0PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CDH1
10MP:00053697.8PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
11MP:00053867.6PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
12MP:00053807.6PIK3CA, BRCA1, PALB2, AKT1, ERBB2, KRAS
13MP:00053877.4PIK3CA, RRAS2, BRCA1, AKT1, KRAS, CDH1
14MP:00053767.4PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
15MP:00036317.2PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
16MP:00107717.0PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
17MP:00053846.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
18MP:00107686.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
19MP:00020066.8CTNNB1, PIK3CA, RRAS2, BRCA1, PALB2, AKT1
20MP:00053856.2PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1
21MP:00053786.1PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1

Publications for Ovarian Cancer, Somatic

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Variations for Ovarian Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Ovarian Cancer, Somatic:

63
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421
7PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Ovarian Cancer, Somatic:

7 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
3ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
4AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
5NC_012920.1: m.14743A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14743: 14743
6MT-CYBNC_012920.1: m.14753C> Tsingle nucleotide variantLikely pathogenicGRCh38Chr MT, 14753: 14753
7MT-CYBNC_012920.1: m.14784T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14784: 14784
8MT-CYBNC_012920.1: m.15058C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15058: 15058
9MT-CYBNC_012920.1: m.15098A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15098: 15098
10MT-CYBNC_012920.1: m.15314G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15314: 15314
11MT-CYBNC_012920.1: m.15328A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15328: 15328
12MT-CYBNC_012920.1: m.15334C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15334: 15334
13MT-CYBNC_012920.1: m.15363A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15363: 15363
14MT-CYBNC_012920.1: m.15453T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15453: 15453
15MT-CYBNC_012920.1: m.15459C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15459: 15459
16MT-CYBNC_012920.1: m.15511T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15511: 15511
17MT-CYBNC_012920.1: m.15884G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15884: 15884
18MT-TTNC_012920.1: m.15890C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15890: 15890
19MT-TTNC_012920.1: m.15928G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15928: 15928
20MT-TTNC_012920.1: m.15932T> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15932: 15932
21MT-TTNC_012920.1: m.15943T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15943: 15943
22MT-CYBNC_012920.1: m.15061A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15061: 15061
23MT-CYBNC_012920.1: m.15148G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15148: 15148
24MT-CYBNC_012920.1: m.15259C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15259: 15259
25MT-CYBNC_012920.1: m.15431G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15431: 15431
26MT-CYBNC_012920.1: m.15452C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15452: 15452
27MT-CYBNC_012920.1: m.15607A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15607: 15607
28MT-CYBNC_012920.1: m.15670T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15670: 15670
29CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
30PARK2PARK2, DELdeletionPathogenic
31OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
32RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Expression for genes affiliated with Ovarian Cancer, Somatic

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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer, Somatic

Search GEO for disease gene expression data for Ovarian Cancer, Somatic.

Pathways for genes affiliated with Ovarian Cancer, Somatic

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Pathways related to Ovarian Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ERBB2, CDH1, CTNNB1
29.5CTNNB1, PIK3CA, CDH1
39.4CTNNB1, CDH1, KRAS
4
Show member pathways
VEGFR1 specific signals37
9.4PIK3CA, CTNNB1, AKT1
59.4PIK3CA, AKT1, CDH1
69.4CDH1, AKT1, PIK3CA
79.4AKT1, KRAS, CTNNB1
8
Show member pathways
9.3ERBB2, AKT1, PIK3CA
99.3AKT1, KRAS, ERBB2
109.3BRCA1, AKT1, CTNNB1
119.2KRAS, PIK3CA, AKT1
12
Show member pathways
9.2AKT1, KRAS, PIK3CA
139.2CTNNB1, ERBB2, AKT1, CDH1
14
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.2AKT1, PIK3CA, BRCA1
15
Show member pathways
IFN-gamma pathway37
9.2AKT1, BRCA1, PIK3CA
169.1CTNNB1, CDH1, AKT1, PIK3CA
179.1PIK3CA, CDH1, CTNNB1, AKT1
18
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.1PIK3CA, AKT1, ERBB2, CTNNB1
199.0CDH1, AKT1, ERBB2, PIK3CA
209.0CTNNB1, KRAS, AKT1, PIK3CA
21
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
9.0PIK3CA, KRAS, CTNNB1, AKT1
22
Show member pathways
8.9ERBB2, AKT1, PIK3CA, KRAS
23
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.9ERBB2, KRAS, PIK3CA, AKT1
24
Show member pathways
8.9KRAS, ERBB2, PIK3CA, AKT1
25
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
8.9PIK3CA, AKT1, ERBB2, KRAS
26
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.9AKT1, PIK3CA, ERBB2, KRAS
27
Show member pathways
8.9PIK3CA, AKT1, ERBB2, KRAS
28
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.9KRAS, ERBB2, AKT1, PIK3CA
298.7KRAS, ERBB2, BRCA1, PIK3CA
308.7CTNNB1, RRAS2, AKT1, CDH1
31
Show member pathways
8.7CTNNB1, CDH1, AKT1, RRAS2
32
Show member pathways
8.6KRAS, PIK3CA, AKT1, ERBB2, CTNNB1
33
Show member pathways
8.5CTNNB1, KRAS, RRAS2, AKT1
348.5AKT1, KRAS, CTNNB1, RRAS2
358.5CTNNB1, KRAS, BRCA1, AKT1, CDH1
36
Show member pathways
8.4KRAS, PIK3CA, AKT1, RRAS2
37
Show member pathways
8.4CDH1, ERBB2, AKT1, RRAS2, CTNNB1
38
Show member pathways
8.4RRAS2, CTNNB1, CDH1, ERBB2, AKT1
398.3CDH1, PIK3CA, AKT1, KRAS, ERBB2, CTNNB1
40
Show member pathways
Signal transduction PTEN pathway59
8.3CTNNB1, CDH1, KRAS, ERBB2, PIK3CA, AKT1
41
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.2PIK3CA, AKT1, ERBB2, CTNNB1, RRAS2
428.1PIK3CA, RRAS2, AKT1, KRAS, CTNNB1
43
Show member pathways
8.1AKT1, CDH1, RRAS2, BRCA1, ERBB2
448.1BRCA1, PIK3CA, AKT1, ERBB2, CTNNB1, KRAS
45
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
7.9CTNNB1, PIK3CA, CDH1, ERBB2, AKT1, RRAS2
46
Show member pathways
7.8CTNNB1, PIK3CA, RRAS2, AKT1, KRAS, CDH1
47
Show member pathways
7.8RRAS2, AKT1, ERBB2, CDH1, BRCA1, CTNNB1
487.8PIK3CA, RRAS2, CTNNB1, KRAS, ERBB2, AKT1
49
Show member pathways
Signaling Pathways in Glioblastoma37
7.8BRCA1, PIK3CA, AKT1, ERBB2, KRAS, CDH1
50
Show member pathways
7.4CDH1, PIK3CA, BRCA1, PARK2, AKT1, KRAS

Compounds for genes affiliated with Ovarian Cancer, Somatic

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Compounds related to Ovarian Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1sodium bisulfite449.7CDH1, CTNNB1, BRCA1
2everolimus44 50 1211.6PIK3CA, ERBB2, AKT1
3celecoxib44 60 29 50 25 1214.5CDH1, CTNNB1, ERBB2, AKT1
4crcs449.4KRAS, CDH1, PIK3CA, CTNNB1
5ag 1478449.4AKT1, ERBB2, CTNNB1, PIK3CA
6indole-3-carbinol449.4CTNNB1, CDH1, AKT1, BRCA1
7egcg449.3ERBB2, CDH1, CTNNB1, PIK3CA
8erlotinib44 50 1211.3ERBB2, PIK3CA, KRAS, CDH1
9herbimycin a44 6010.3ERBB2, CDH1, AKT1, CTNNB1
10nocodazole44 1210.3CDH1, AKT1, CTNNB1, BRCA1
114-hydroxytamoxifen449.3CTNNB1, AKT1, BRCA1, ERBB2
12cetuximab44 50 1211.3KRAS, CTNNB1, ERBB2
13geldanamycin44 50 60 1212.2CTNNB1, CDH1, ERBB2, PARK2
14curcumin449.2ERBB2, CDH1, CTNNB1, AKT1
1517-(allylamino)-17-demethoxygeldanamycin449.2ERBB2, CDH1, AKT1
16resveratrol44 60 25 1212.2PIK3CA, ERBB2, BRCA1, CTNNB1
17docetaxel44 50 60 1212.1BRCA1, CDH1, ERBB2, PIK3CA
18adriamycin449.1BRCA1, ERBB2, AKT1, CDH1, CTNNB1
19imatinib44 50 1211.0KRAS, PIK3CA, ERBB2, CTNNB1
20p002449.0CTNNB1, CDH1, KRAS, ERBB2, BRCA1
21phosphotyrosine449.0CTNNB1, PIK3CA, BRCA1, ERBB2, CDH1
22etoposide44 50 60 1211.9PIK3CA, BRCA1, ERBB2, CDH1, AKT1
23glycogen44 259.8CDH1, AKT1, PIK3CA, CTNNB1, PARK2
24mg 13244 609.8CDH1, CTNNB1, AKT1, PARK2, BRCA1
25gefitinib44 50 1210.8PIK3CA, KRAS, AKT1, CTNNB1, ERBB2, CDH1
26rapamycin448.7AKT1, ERBB2, KRAS, CTNNB1, CDH1, PIK3CA
27ly294002448.7PIK3CA, ERBB2, AKT1, KRAS, CDH1, CTNNB1
28wortmannin448.7ERBB2, AKT1, KRAS, CTNNB1, CDH1, PIK3CA
29guanine44 25 1210.7ERBB2, PARK2, BRCA1, AKT1, CTNNB1
30tamoxifen44 50 29 1211.7BRCA1, CTNNB1, CDH1, ERBB2, AKT1, PIK3CA
31doxorubicin44 50 1210.6PIK3CA, CTNNB1, BRCA1, ERBB2, AKT1, CDH1
32genistein44 29 60 3 25 1213.6BRCA1, CDH1, CTNNB1, PIK3CA, ERBB2, AKT1
33progesterone44 29 60 25 1212.6BRCA1, ERBB2, CDH1, CTNNB1, PIK3CA
345fluorouracil448.6BRCA1, CTNNB1, CDH1, KRAS, ERBB2, PIK3CA
35phosphoinositide448.6PARK2, PIK3CA, KRAS, CTNNB1, AKT1
36paraffin448.6AKT1, ERBB2, BRCA1, CDH1, CTNNB1, KRAS
37glutamine448.6PARK2, AKT1, CTNNB1, BRCA1, CDH1
38alanine448.3CTNNB1, ERBB2, AKT1, PARK2, BRCA1, CDH1
39retinoic acid44 259.2BRCA1, KRAS, PIK3CA, CDH1, CTNNB1, AKT1
40cisplatin44 50 60 1211.2CTNNB1, BRCA1, KRAS, PIK3CA, AKT1, ERBB2
41phosphatidylinositol448.2KRAS, CTNNB1, PIK3CA, BRCA1, CDH1, AKT1
42testosterone44 60 25 1211.0BRCA1, PARK2, AKT1, ERBB2, PIK3CA, CTNNB1
43h2o2447.9CTNNB1, ERBB2, AKT1, PARK2, BRCA1, PIK3CA
44gtp44 298.9PARK2, PIK3CA, KRAS, CTNNB1, RRAS2, AKT1
45agar447.9CDH1, PIK3CA, RRAS2, BRCA1, CTNNB1, ERBB2
46paclitaxel44 50 129.6BRCA1, PARK2, AKT1, KRAS, CDH1, CTNNB1
47vegf447.6BRCA1, CDH1, CTNNB1, KRAS, ERBB2, AKT1
48estrogen447.6CDH1, KRAS, ERBB2, AKT1, PARK2, CTNNB1
49serine446.8CDH1, KRAS, ERBB2, AKT1, PARK2, RRAS2
50tyrosine446.8BRCA1, AKT1, CTNNB1, CDH1, KRAS, ERBB2

GO Terms for genes affiliated with Ovarian Cancer, Somatic

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Cellular components related to Ovarian Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:01634210.0CTNNB1, CDH1
2lateral plasma membraneGO:0163289.9CTNNB1, CDH1
3cell-cell adherens junctionGO:0059139.8CTNNB1, CDH1
4basolateral plasma membraneGO:0163239.6CTNNB1, CDH1, ERBB2
5cytoplasmic side of plasma membraneGO:0098989.6CTNNB1, CDH1
6aggresomeGO:0162359.6PARK2, CDH1
7perinuclear region of cytoplasmGO:0484719.0PARK2, ERBB2, CDH1, CTNNB1
8plasma membraneGO:0058866.8CTNNB1, PIK3CA, RRAS2, BRCA1, AKT1, ERBB2

Biological processes related to Ovarian Cancer, Somatic according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.2CDH1, CTNNB1
2regulation of angiogenesisGO:04576510.0CTNNB1, ERBB2
3striated muscle cell differentiationGO:0511469.9KRAS, AKT1
4positive regulation of nitric-oxide synthase activityGO:0510009.9AKT1, KRAS
5protein kinase B signalingGO:0434919.8AKT1, PIK3CA
6cellular response to indole-3-methanolGO:0716819.7CTNNB1, CDH1, BRCA1
7positive regulation of MAP kinase activityGO:0434069.7KRAS, ERBB2
8negative regulation of release of cytochrome c from mitochondriaGO:0902019.7AKT1, PARK2
9phosphatidylinositol-mediated signalingGO:0480159.6ERBB2, AKT1, PIK3CA
10positive regulation of protein phosphorylationGO:0019349.6KRAS, ERBB2, AKT1
11insulin receptor signaling pathwayGO:0082869.4KRAS, AKT1, PIK3CA
12androgen receptor signaling pathwayGO:0305219.4CTNNB1, BRCA1
13protein autoubiquitinationGO:0518659.3BRCA1, PARK2
14negative regulation of neuron apoptotic processGO:0435249.3PIK3CA, PARK2, KRAS
15fibroblast growth factor receptor signaling pathwayGO:0085439.2KRAS, ERBB2, AKT1, PIK3CA
16Fc-epsilon receptor signaling pathwayGO:0380959.2PIK3CA, AKT1, ERBB2, KRAS
17epidermal growth factor receptor signaling pathwayGO:0071739.2KRAS, ERBB2, AKT1, PIK3CA
18neurotrophin TRK receptor signaling pathwayGO:0480119.2KRAS, ERBB2, AKT1, PIK3CA
19apoptotic processGO:0069159.1BRCA1, AKT1, CDH1, CTNNB1
20innate immune responseGO:0450878.9PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
21protein ubiquitinationGO:0165678.9AKT1, PARK2, BRCA1

Molecular functions related to Ovarian Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.6ERBB2, CDH1, CTNNB1
2kinase bindingGO:0199009.6CTNNB1, PARK2
3androgen receptor bindingGO:0506819.6BRCA1, CTNNB1
4kinase activityGO:0163019.4PIK3CA, AKT1
5enzyme bindingGO:0198999.3CTNNB1, AKT1, BRCA1
6protein bindingGO:0055155.9CTNNB1, PIK3CA, RRAS2, BRCA1, PARK2, PALB2

Products for genes affiliated with Ovarian Cancer, Somatic

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Sources for Ovarian Cancer, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
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36MGI
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40NDF-RT
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44Novoseek
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52QIAGEN
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61UMLS
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