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MCID: OVR078

Ovarian Cancer, Somatic malady
4 genes, 1 tissue, 68 related diseases, clinical trials.

Summaries for Ovarian Cancer, Somatic

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33OMIM, 22MalaCards
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MalaCards: Ovarian Cancer, Somatic, also known as malignant neoplasm of ovary, is related to ovarian cancer and breast cancer, somatic. An important gene associated with Ovarian Cancer, Somatic is OPCML (opioid binding protein/cell adhesion molecule-like), and among its related pathways are Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics and Cell adhesion PLAU signaling. The compounds 4-hydroxytamoxifen and ptdins(3)p have been mentioned in the context of this disorder. Affiliated tissues include ovary.

OMIM: 604370

Aliases & Descriptions for Ovarian Cancer, Somatic

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33OMIM, 43UMLS
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ovarian cancer, somatic 33
malignant neoplasm of ovary 43

Related Diseases for Ovarian Cancer, Somatic

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13GeneCards, 14GeneDecks
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Diseases related to ovarian cancer, somatic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer28.4PIK3CA, AKT1, ERBB2, OPCML
2breast cancer, somatic12.8AKT1, PIK3CA
3colorectal cancer, somatic12.8AKT1, PIK3CA
4leopard syndrome12.8PIK3CA, AKT1
5cowden disease12.8PIK3CA, AKT1
6focal cortical dysplasia12.7PIK3CA, AKT1
7gastric cancer, somatic12.6PIK3CA, ERBB2
8ampulla of vater carcinoma12.6PIK3CA, ERBB2
9bilateral breast cancer12.6PIK3CA, ERBB2
10ovarian clear cell adenocarcinoma12.5ERBB2, PIK3CA
11balanitis12.5PIK3CA, AKT1
12abrikosov's tumor12.5AKT1, PIK3CA
13clear cell adenocarcinoma12.5PIK3CA, ERBB2
14estrogen-receptor positive breast cancer12.5PIK3CA, ERBB2
15salivary gland cancer12.4ERBB2, AKT1
16germ cell cancer12.4AKT1, ERBB2
17ovarian mucinous neoplasm12.4PIK3CA, ERBB2
18cervical adenocarcinoma12.2AKT1, ERBB2
19bladder carcinoma12.0OPCML, ERBB2, PIK3CA
20rhabdoid tumors12.0ERBB2, AKT1, PIK3CA
21ductal carcinoma in situ12.0PIK3CA, AKT1, ERBB2
22breast cancer12.0PIK3CA, AKT1, ERBB2
23malignant pleural mesothelioma12.0ERBB2, AKT1, PIK3CA
24adenoid cystic carcinoma12.0ERBB2, AKT1, PIK3CA
25gastrointestinal stromal tumor12.0PIK3CA, AKT1, ERBB2
26endometrial adenocarcinoma12.0ERBB2, AKT1, PIK3CA
27adenoiditis12.0PIK3CA, AKT1, ERBB2
28noma11.9ERBB2, AKT1, PIK3CA
29gastric adenocarcinoma11.9ERBB2, AKT1, PIK3CA
30pancreatic ductal carcinoma11.9PIK3CA, AKT1, ERBB2
31papillary thyroid carcinoma11.9ERBB2, AKT1, PIK3CA
32liver cancer11.9OPCML, ERBB2, AKT1
33pancreatic carcinoma11.9ERBB2, AKT1, PIK3CA
34medulloblastoma11.9PIK3CA, AKT1, ERBB2
35malignant glioma11.9ERBB2, AKT1, PIK3CA
36bartter disease11.9PIK3CA, AKT1, ERBB2
37non-small cell lung carcinoma11.9ERBB2, AKT1, PIK3CA
38thyroid cancer11.9ERBB2, AKT1, PIK3CA
39endometrial carcinoma11.9PIK3CA, AKT1, ERBB2
40laryngitis11.9ERBB2, AKT1, PIK3CA
41esophageal cancer11.9ERBB2, AKT1, PIK3CA
42endometriosis11.8PIK3CA, AKT1, ERBB2
43endometrial cancer11.8ERBB2, AKT1, PIK3CA
44herpes simplex11.8ERBB2, AKT1, PIK3CA
45oral squamous cell carcinoma11.8ERBB2, AKT1, PIK3CA
46nasopharyngitis11.8ERBB2, AKT1, PIK3CA
47thyroid carcinoma11.7ERBB2, AKT1, PIK3CA
48retinoblastoma11.6PIK3CA, AKT1, ERBB2
49cholangiocarcinoma11.6ERBB2, AKT1, PIK3CA
50lung carcinoma11.5PIK3CA, AKT1, ERBB2

Graphical network of the top 20 diseases related to ovarian cancer, somatic:



Graphical network of diseases related to ovarian cancer, somatic

Clinical Features for Ovarian Cancer, Somatic

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33OMIM
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Clinical features from OMIM: 604370

Drugs & Therapeutics for Ovarian Cancer, Somatic

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
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Approved drugs:

Search CenterWatch for ovarian cancer, somatic

Drug clinical trials:

Search ClinicalTrials for ovarian cancer, somatic

Search NIH Clinical Center for ovarian cancer, somatic

Search CenterWatch for ovarian cancer, somatic

Genetic Tests for Ovarian Cancer, Somatic

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Anatomical Context for Ovarian Cancer, Somatic

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22MalaCards
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MalaCards organs/tissues related to ovarian cancer, somatic:

22
Ovary

Phenotypes for genes affiliated with Ovarian Cancer, Somatic

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Publications for genes affiliated with Ovarian Cancer, Somatic

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Expression for genes affiliated with Ovarian Cancer, Somatic

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Ovarian Cancer, Somatic

Pathways for genes affiliated with Ovarian Cancer, Somatic

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34PharmGKB, 10EMD Millipore, 41Thomson Reuters, 20KEGG
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Pathways related to ovarian cancer, somatic according to GeneDecks:

(show top 50)    (show all 141)
idPathwayScoreTop Affiliating Genes
1Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics3410.2AKT1
2Cell adhesion PLAU signaling1010.0PIK3CA
3G-protein signaling Cross-talk between Ras-family GTPases109.7AKT1, PIK3CA
4G-protein signaling_Cross-talk between Ras-family GTPases419.7PIK3CA, AKT1
5Apoptosis and survival_NGF signaling pathway419.7AKT1, PIK3CA
6Apoptosis and survival NGF signaling pathway109.7PIK3CA, AKT1
7Sorafenib Pharmacodynamics349.7PIK3CA, AKT1
8Immune response IL-23 signaling pathway109.7AKT1, PIK3CA
9Immune response_IL-10 signaling pathway419.7AKT1, PIK3CA
10Immune response IL-10 signaling pathway109.7PIK3CA, AKT1
11Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1109.7AKT1, PIK3CA
12Immune response_IL-23 signaling pathway419.7PIK3CA, AKT1
13Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1419.7AKT1, PIK3CA
14Development_CNTF receptor signaling419.7PIK3CA, AKT1
15Development CNTF receptor signaling109.6AKT1, PIK3CA
16Development PDGF signaling via STATs and NF-kB109.6AKT1, PIK3CA
17Development_PDGF signaling via STATs and NF-kB419.6PIK3CA, AKT1
18Development Growth hormone signaling via PI3K/AKT and MAPK cascades109.6PIK3CA, AKT1
19Development_Growth hormone signaling via PI3K/AKT and MAPK cascades419.6AKT1, PIK3CA
20Transcription_Receptor-mediated HIF regulation419.6PIK3CA, AKT1
21Development_VEGF-family signaling419.5PIK3CA, AKT1
22Development VEGF-family signaling109.5AKT1, PIK3CA
23Carbohydrate digestion and absorption209.5AKT1, PIK3CA
24Cell adhesion_PLAU signaling419.4AKT1, PIK3CA
25Development EGFR signaling via small GTPases109.4PIK3CA, ERBB2
26Development_EGFR signaling via small GTPases419.4ERBB2, PIK3CA
27Development Dopamine D2 receptor transactivation of EGFR109.4PIK3CA, AKT1
28Development_Neurotrophin family signaling419.3AKT1, PIK3CA
29Development Angiopoietin - Tie2 signaling109.2AKT1, PIK3CA
30Development_Angiopoietin - Tie2 signaling419.0AKT1, PIK3CA
31Development_EGFR signaling via PIP3419.0ERBB2, PIK3CA, AKT1
32Development EGFR signaling via PIP3109.0PIK3CA, AKT1, ERBB2
33Apoptosis and survival Role of CDK5 in neuronal death and survival109.0ERBB2, AKT1, PIK3CA
34Apoptosis and survival_Role of CDK5 in neuronal death and survival419.0PIK3CA, AKT1, ERBB2
35Development ERBB-family signaling109.0PIK3CA, ERBB2, AKT1
36Endometrial cancer208.9PIK3CA, AKT1, ERBB2
37Development_ERBB-family signaling418.9AKT1, ERBB2, PIK3CA
38Non-small cell lung cancer208.9AKT1, PIK3CA, ERBB2
39Development Ligand-independent activation of ESR1 and ESR2108.9PIK3CA, AKT1, ERBB2
40Development_Ligand-independent activation of ESR1 and ESR2418.9ERBB2, AKT1, PIK3CA
41Development EGFR signaling pathway108.9ERBB2, PIK3CA, AKT1
42EGFR Inhibitor Pathway, Pharmacodynamics348.9ERBB2, PIK3CA, AKT1
43Pancreatic cancer208.9PIK3CA, ERBB2, AKT1
44Translation_Non-genomic (rapid) action of Androgen Receptor418.9PIK3CA, AKT1, ERBB2
45Translation Non-genomic (rapid) action of Androgen Receptor108.9PIK3CA, AKT1, ERBB2
46Development_EGFR signaling pathway418.9ERBB2, AKT1, PIK3CA
47ErbB signaling pathway208.9AKT1, ERBB2, PIK3CA
48Prostate cancer208.9ERBB2, AKT1, PIK3CA
49Focal adhesion208.9ERBB2, AKT1, PIK3CA
50Pathways in cancer208.9PIK3CA, AKT1, ERBB2

Compounds for genes affiliated with Ovarian Cancer, Somatic

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32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to ovarian cancer, somatic according to GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
14-hydroxytamoxifen32 9.8ERBB2
2ptdins(3)p32 9.7AKT1, PIK3CA
3l-nmma32 9.6AKT1, PIK3CA
4metformin32 34 9 9 12.5PIK3CA, AKT1
5erlotinib32 34 9 9 12.4ERBB2, PIK3CA
6trastuzumab32 34 9 9 12.3ERBB2, PIK3CA
717-(allylamino)-17-demethoxygeldanamycin32 9.3ERBB2, AKT1
8celecoxib32 42 34 9 18 9 14.1ERBB2, AKT1
9tetracycline32 9 9 11.0AKT1, ERBB2
10gefitinib32 34 9 9 11.9ERBB2, PIK3CA, AKT1
11ag 147832 8.9ERBB2, AKT1, PIK3CA
12agar32 8.9PIK3CA, AKT1, ERBB2
13etoposide32 42 9 9 11.9PIK3CA, AKT1, ERBB2
14tamoxifen32 34 9 9 11.8ERBB2, AKT1, PIK3CA
15paclitaxel32 34 9 9 11.8PIK3CA, ERBB2, AKT1
16rapamycin32 42 9.8AKT1, ERBB2, PIK3CA
17doxorubicin32 34 9 9 11.8PIK3CA, ERBB2, AKT1
18ly29400232 8.8AKT1, PIK3CA, ERBB2
19wortmannin32 42 9.8ERBB2, AKT1, PIK3CA
20genistein32 9 18 9 11.8PIK3CA, AKT1, ERBB2
21cisplatin32 34 9 9 11.7ERBB2, AKT1, PIK3CA
22gemcitabine32 34 9 9 11.7AKT1, ERBB2
23testosterone32 9 18 9 11.6ERBB2, AKT1, PIK3CA
24vegf32 8.5PIK3CA, AKT1, ERBB2
25dexamethasone32 42 34 9 9 12.4PIK3CA, ERBB2, AKT1

GO Terms for genes affiliated with Ovarian Cancer, Somatic

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12Gene Ontology
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Cellular components related to ovarian cancer, somatic according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lamellipodiumGO:0300279.3PIK3CA, AKT1

Biological processes related to ovarian cancer, somatic according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein kinase B signaling cascadeGO:0434919.4AKT1, PIK3CA
2positive regulation of peptidyl-serine phosphorylationGO:0331389.4AKT1, PIK3CA
3glucose metabolic processGO:0060069.3AKT1, PIK3CA
4T cell costimulationGO:0312959.2AKT1, PIK3CA
5positive regulation of cell growthGO:0303079.0AKT1, ERBB2
6positive regulation of protein phosphorylationGO:0019348.7ERBB2, AKT1
7phosphatidylinositol-mediated signalingGO:0480158.7ERBB2, AKT1, PIK3CA
8epidermal growth factor receptor signaling pathwayGO:0071738.7ERBB2, AKT1, PIK3CA

Molecular functions related to ovarian cancer, somatic according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.3PIK3CA, AKT1

Sources for Ovarian Cancer, Somatic

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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