Ovarian Carcinoma malady

Wikipedia: Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early...⁴⁴ more...

MalaCards: Ovarian Carcinoma, also known as epithelial ovarian cancer, is related to carcinoma and prostatitis. An important gene associated with Ovarian Carcinoma is ENOX2 (ecto-NOX disulfide-thiol exchanger 2), and among its related pathways are Molecular Mechanisms of Cancer and Pancreatic Adenocarcinoma. The compounds calcium and progesterone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Descriptions:

ovarian carcinoma 6 7 8 33 32 epithelial ovarian cancer 43

Diseases related to ovarian carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 836)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	137.9	PIKFYVE, PIP, PIK3CA, PIK3CG, PI3, LRRC32
2	prostatitis	105.3	PIP, PIK3CA, PIK3CG, NDN, PDCD4, PDCD5
3	adenocarcinoma	101.5	PIP, PIK3CA, PIK3CG, NDN, PDCD5, RECK
4	leukemia	94.9	PIK3CA, PIK3CG, PDCD4, PDCD5, RECK, REL
5	breast carcinoma	89.5	PIKFYVE, PIP, PIK3CA, PIK3CG, PI3, RECK
6	melanoma	89.2	PIK3CA, PIK3CG, PI3, NDN, RECK, REL
7	colon cancer	84.5	PIK3CA, PIK3CG, PDCD4, RECK, RELA, PCNA
8	cervicitis	80.7	PIK3CA, PIK3CG, PDCD4, RECK, RELA, REV1
9	thyroiditis	80.6	PIK3CA, PIK3CG, NDN, PDCD5, RECK, RELA
10	esophagitis	78.3	PIK3CA, PIK3CG, PDCD4, PDCD5, RECK, RELA
11	hypoxia	71.9	PIK3CA, PIK3CG, NDN, PDCD4, RECK, RELA
12	adenoma	71.7	PIK3CA, PDCD4, RECK, KIT, KISS1, KISS1R
13	colon carcinoma	70.6	PIK3CA, PIK3CG, PDCD4, REV3L, KIT, VTN
14	endometrial carcinoma	65.9	PIK3CA, PIK3CG, RELA, KIT, KISS1, KISS1R
15	epithelial ovarian cancer	61.8	PIK3CA, PIK3CG, RELA, KISS1, KISS1R, BUB1B
16	peritonitis	59.9	RELA, KIT, VTN, PCNA, RBP4, SELL
17	cholesterol	55.1	PIK3CA, PIK3CG, NDN, RECK, REL, RELA
18	pancreatitis	54.9	PIK3CA, PIK3CG, PI3, RECK, RELA, KIT
19	colorectal cancer	53.6	PIK3CA, PIK3CG, PDCD4, RECK, KIT, PCNA
20	endometriosis	52.3	PIK3CA, RELA, VTN, PCNA, SERPINE1, VIM
21	colon adenocarcinoma	51.8	VTN, BUB1B, BSG, BRCA1, VEGFA, VDR
22	hepatocellular carcinoma	51.6	PIK3CA, PIK3CG, PDCD4, RECK, RELA, REV3L
23	gastric cancer	50.6	PIK3CA, PIK3CG, PDCD4, RECK, RELA, REV3L
24	malignant mesothelioma	48.5	PIK3CG, KIT, PCNA, RB1, VIM, VEGFA
25	neuronitis	47.7	PIK3CA, PIK3CG, NDN, RECK, REL, RELA
26	anemia	45.9	RELA, REV1, KIT, PCNA, RB1, SELL
27	tuberculosis	45.8	PIK3CG, RELA, REV1, RB1, SELL, VIM
28	lung carcinoma	45.6	PIK3CA, PIK3CG, RECK, PCNA, BUB1B, RB1
29	obesity	43.8	PIK3CA, PIK3CG, RECK, RELA, KISS1, PCNA
30	gingivitis	43.5	PIK3CG, PCNA, SELL, SETD2, SERPINE1, SERPINA3
31	sarcoma	42.9	PIK3CA, PIK3CG, RECK, RELA, REV3L, KIT
32	germ cell tumor	42.9	KIT, PCNA, BUB1B, RB1, BRAF, BRCA2
33	polyposis	42.8	PIK3CG, RELA, PCNA, BUB1B, RB1, SERPINE1
34	wilms tumor	41.8	PCNA, BUB1B, SETD2, VIM, BRCA1, BRCA2
35	neuroblastoma	40.1	PIK3CA, PIK3CG, NDN, RECK, RELA, KIT
36	herpes simplex	39.6	PIK3CA, PIK3CG, RECK, REV3L, PCNA, SERPINE1
37	breast-ovarian cancer	38.9	PIK3CA, KIT, VTCN1, PCNA, PCM1, RB1
38	endometrial cancer	38.6	PIK3CA, PIK3CG, PDCD4, PCNA, RB1, RBL2
39	cervical cancer	38.4	PIK3CA, PIK3CG, RELA, VTN, PCNA, RB1
40	benign tumors	38.3	PIK3CG, PCNA, VIM, BSG, RARB, RASSF1
41	arthritis	37.5	PIK3CG, PDCD5, RECK, REL, RELA, KIT
42	myeloid leukemia	37.5	PIK3CA, PIK3CG, PDCD5, RECK, RELA, KIT
43	ovarian cancer	37.4	BRCA1, MUC16, CEACAM3, FSCN1, FSHR, FOLR1
44	cystadenoma	37.1	KIT, PCNA, VIM, BRAF, BRCA1, VHL
45	adenomatous polyposis coli	36.9	PIK3CG, BUB1B, MYC, BMP6, RAN, BIRC5
46	breast cancer	36.4	RECK, BRCA1, BRCA2, VEGFA, VDR, RAD51
47	ependymoma	36.2	VTN, RB1, RBP4, VIM, BRCA2, VEGFA
48	gonococcal synovitis	36.1	PIK3CA, PIK3CG, PI3, RECK, REL, RELA
49	down syndrome	36.0	KISS1, KISS1R, SERPINE1, SERPINA3, VEGFA, BMP6
50	breast cancer susceptibility	35.9	RECK, BRCA1, BRCA2, VEGFA, VDR, RAD51

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ovarian carcinoma:

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MGI Mouse Phenotypes related to ovarian carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	40.9	PIKFYVE, PIK3CA, PIK3CG, NDN, REL, RELA
2	mortality/aging	MP:0010768	37.8	PIKFYVE, PIK3CA, NDN, PDCD4, RECK, REL
3	nervous system phenotype	MP:0003631	31.4	NDN, RECK, REL, RELA, REV3L, KIT
4	digestive/alimentary phenotype	MP:0005381	27.0	REL, KIT, KISS1, KISS1R, RB1, RBP2
5	integument phenotype	MP:0010771	26.7	PIK3CG, NDN, RECK, REL, RELA, KIT
6	embryogenesis phenotype	MP:0005380	26.0	PIKFYVE, PIK3CA, RECK, REL, REV3L, KIT
7	normal phenotype	MP:0002873	25.8	NDN, RELA, REV1, KISS1R, VTCN1, VTN
8	behavior/neurological phenotype	MP:0005386	25.6	PIK3CA, NDN, KIT, KISS1R, RB1, VIM
9	skeleton phenotype	MP:0005390	25.5	PIK3CG, RECK, REL, RELA, KIT, BUB1B
10	muscle phenotype	MP:0005369	24.6	PIK3CA, PIK3CG, NDN, RELA, KIT, BUB1B
11	reproductive system phenotype	MP:0005389	23.6	PIK3CA, PDCD4, KISS1, KISS1R, BUB1B, RBL2
12	renal/urinary system phenotype	MP:0005367	22.4	PDCD4, KIT, KISS1, KISS1R, BRAF, BRCA1
13	limbs/digits/tail phenotype	MP:0005371	19.3	RECK, RELA, KIT, RB1, RBL2, NBR1
14	endocrine/exocrine gland phenotype	MP:0005379	17.6	PDCD4, KISS1, KISS1R, RBL2, SELL, BRCA1
15	craniofacial phenotype	MP:0005382	17.6	REV3L, KIT, BMI1, BMP4, RARG, PAX8
16	hearing/vestibular/ear phenotype	MP:0005377	16.2	KIT, RB1, RBP1, VDR, MYC, BMP4
17	liver/biliary system phenotype	MP:0005370	14.8	RECK, REL, KIT, RBP1, VHL, VEGFA
18	pigmentation phenotype	MP:0001186	14.6	KIT, RB1, RBP1, BRAF, BRCA1, MYC
19	respiratory system phenotype	MP:0005388	13.2	NDN, REL, SELL, BRCA1, LPAR2, LIF
20	no phenotypic analysis	MP:0003012	INF	NDN, PCNA, RB1, RBL2, VEGFA, MYC
21	adipose tissue phenotype	MP:0005375	INF	PIK3CA, BUB1B, RB1, SERPINE1, BRAF, BRCA1
22	hematopoietic system phenotype	MP:0005397	INF	REV1, REV3L, KIT, KISS1R, VTCN1, PCNA
23	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, PIK3CG, RECK, REL, RELA, REV3L
24	vision/eye phenotype	MP:0005391	INF	PIK3CA, RELA, KIT, BUB1B, RB1, RBL2
25	immune system phenotype	MP:0005387	INF	PDCD4, REL, REV1, REV3L, KIT, KISS1R
26	tumorigenesis	MP:0002006	INF	PIK3CA, PDCD4, REV3L, KIT, BUB1B, RB1
27	growth/size phenotype	MP:0005378	INF	PIK3CA, PIK3CG, RECK, REL, RELA, REV1
28	cellular phenotype	MP:0005384	INF	PIKFYVE, PIK3CA, PIK3CG, NDN, REL, RELA
29	other phenotype	MP:0005395	INF	RECK, RBP2, RARG, RARA, RARB, CLU

Articles related to ovarian carcinoma:

(show top 50)    (show all 1324)

id	Title	Authors	Year	Affiliating Genes
1	Clinical significance of astrocyte elevated gene-1 ex pression in human epithelial ovarian carcinoma. (21293286)	Meng F.... Lou G.	2011	MTDH
2	Functional roles of Src and Fgr in ovarian carcinoma. (21300758)	Kim H.S.... Sood A.K.	2011	SRC, FGR
3	Osteopontin expression in ovarian carcinoma effusions is related to improved clinical outcome. (21315424)	Davidson B.... Shih I.e.M.	2011	SPP1
4	Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin. (18930836)	Colomiere M.... Ahmed N.	2009	EGF, CDH2, ITGA6
5	E-cadherin promoter methylation and demethylation in epithelial ovarian carcinoma cells (19957556)	Qu P.P.... Li N.	2009	CDH1
6	Expression of hyaluronan synthases (HAS1-3) and hyalu ronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between H YAL1 and hyaluronan content. (19435493)	Nykopp T.K.... Anttila M.	2009	HYAL2, HYAL1, HAS1
7	Association of EGFR expression with angiogenesis and chemoresistance in ovarian carcinoma (19538870)	Chen A.P.... Sun X.L.	2009	EGFR, MVP
8	Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (19672860)	Wu G.Q.... Kung H.F.	2009	CCND1, CDK20
9	Expression of leukaemia inhibitory factor in epithelial ovarian carcinoma: correlation with clinical characteristics. (18540977)	Ye F.... Xie X.	2008	LIF
10	NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. (18593915)	Engels K.... Stauber R.H.	2008	BIRC5, NOS2
11	Distribution of p53 expression in tissue from 774 Danish ovarian tumour patients and its prognostic significance in ovarian carcinomas. (18452430)	Hogdall E.V.... Kjaer S.K.	2008	TP53
12	Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus. (17437010)	Tomlinson V.A.... Abbott C.M.	2007	EEF1A2
13	Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma. (17419711)	Ralph S.... Jayson G.C.	2007	VEGFA, HPSE, HSPE1
14	DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma. (17947481)	Kulkarni A.A.... Stoeber K.	2007	MCM2, GMNN
15	Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. (17374643)	Nazarenko I.... Sers C.	2007	PPP2R1A, PPP2R4, PLA2G16
16	MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma. (16213010)	Guminski A.D.... Defazio A.	2006	ABCC2
17	Interactions of ovarian carcinoma cells and human peritoneal mesothelial cells involved in matrix metalloproteinases expressions of ovarian carcinoma cells (16640888)	Zhang J.J.... Wang B.	2006	MMP2, MMP9, FN1
18	Peritoneal tuberculosis with elevated serum CA 125 level mimicking advanced ovarian carcinoma in an adolescent. (16562790)	CorapAsioA9lu F.... Arisoy E.S.	2006	CGB
19	Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells. (17185520)	Kajiyama H.... Kikkawa F.	2006	MMP2
20	Epigenetic regulation of maspin expression in human ovarian carcinoma cells. (16457875)	Rose S.L.... Domann F.E.	2006	TP53, SERPINB5
21	Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma. (16633060)	Kobel M.... Hauptmann S.	2006	MSN, EZR
22	Expressions of VEGF/VEGFRs and activation of STATs in ovarian carcinoma (15771796)	Chen B.Y.... LA1 W.G.	2005	FLT1, KDR, VEGFA
23	Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma. (14871965)	Apte S.M.... Fidler I.J.	2004	PDGFRB
24	Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy. (15102688)	Nakayama K.... Takebayashi Y.	2004	TP53, ATP7B
25	Response of combination platinum and gemcitabine chem otherapy for recurrent epithelial ovarian carcinoma. (15581960)	Villella J.... Lele S.	2004	EPO
26	Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. (14633716)	Nishiyama N.... Kopecek J.	2003	CDK4, HSPB1, APAF1
27	beta tubulin mutations are rare in human ovarian carcinoma. (12680167)	Lamendola D.E.... Seiden M.V.	2003	TUBB
28	The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. (12839961)	Hellstrom I.... Hellstrom K.E.	2003	WFDC2
29	CA125 and UQCRFS1 FISH studies of ovarian carcinoma. (12821338)	Kaneko S.J.... Young S.R.	2003	UQCRFS1, MUC16
30	Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients. (12893187)	Moilanen J.... Carpen O.	2003	EZR
31	Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers. (12856722)	Casey R.C.... Skubitz A.P.	2003	MMP2
32	Distribution of HER-2 overexpression in ovarian carcinoma tissue and its prognostic value in patients with ovarian carcinoma: from the Danish MALOVA Ovarian Cancer Study. (12833457)	HA... gdall C.K.	2003	ERBB2
33	Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. (12235007)	Gillan L.... Chang D.D.	2002	POSTN
34	Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. (12177805)	Luo L.Y.... Diamandis E.P.	2002	RPL8, TGIF1, RPL3
35	ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro. (12193113)	Salani D.... Bagnato A.	2002	EDNRA, EDN1
36	Comparative genomic hybridization of microdissected familial ovarian carcinoma: two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma. (11598149)	Zweemer R.P.... van Diest P.J.	2001	RAD51, BRCA1, BRCA2
37	In vitro sensitivity of fresh ovarian carcinoma specimens to CPT-11 (irinotecan). (10021292)	O'meara A.T.... Sevin B.U.	1999	TOP1
38	Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines. (10389759)	Asschert J.G.... de Vries E.G.	1999	CEBPB
39	Cytotoxic effect of interferon-alpha2a in combination with all-trans retinoic acid or cisplatin in human ovarian carcinoma cell line s. (9625433)	Jozan S.... Bugat R.	1998	IFNA2
40	The role of cytokeratin 7 in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract (11244983)	Yang W.... Shen M.	1998	KRT7
41	Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells. (9301457)	Corona G.... Boiocchi M.	1997	FOLR1
42	Clinical correlations of multidrug resistance gene expression in ovarian carcinoma (9387523)	Chen X.... Huang W.	1996	ABCB1
43	The value of CA125 and LDH assays in assisting diagnosis of epithelial ovarian carcinoma (9389070)	Qie M.... He B.	1996	MUC16
44	Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer. (8983343)	Alakhov VYu .... Kabanov A.V.	1996	ABCB1, ABCB11
45	CD3-CD28 costimulation as a means to avoiding T cell preactivation in bispecific monoclonal antibody-based treatment of ovarian carcinoma. (8968099)	Mazzoni A.... Canevari S.	1996	FOLR1
46	Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells. (7767986)	Krupitza G.... Dittrich C.	1995	MYC
47	Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19. (8204360)	Mantovani L.T.... Colnaghi M.I.	1994	FOLR1
48	Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone. (8490200)	Saunders D.E.... Deppe G.	1993	MYC
49	Very frequent loss of heterozygosity throughout chromosome 17 in sporadic ovarian carcinoma. (8098014)	Foulkes W.D.... Trowsdale J.	1993	BRCA1
50	Investigations on cell-mediated immunity in patients with breast and ovarian carcinomas receiving a combination of chemotherapy and immunotherapy with thymopentin. (2232966)	Mallmann P.... Krebs D.	1990	TMPO

Genes related to ovarian carcinoma according to GeneCards:

(show top 50)    (show all 773)

id	Symbol	Description	Score	GeneCards Section Context
1	ENOX2	ecto-NOX disulfide-thiol exchanger 2	11.1	Publications, Summaries, Orthologs, Expressions (show all 5 sections) Aliases & Descriptions
2	DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	11.0	Summaries, Publications
3	AKT2	v-akt murine thymoma viral oncogene homolog 2	11.0	Summaries, Publications
4	TNNI2	troponin I type 2 (skeletal, fast)	11.0	Publications, Summaries
5	POLD2	polymerase (DNA directed), delta 2, accessory subunit	11.0	Summaries, Publications
6	HOXB7	homeobox B7	11.0	Publications, Summaries
7	MUC16	mucin 16, cell surface associated	11.0	Aliases & Descriptions, Expressions, Publications
8	OCIAD1	OCIA domain containing 1	11.0	Publications, Aliases & Descriptions
9	NBR1	neighbor of BRCA1 gene 1	11.0	Aliases & Descriptions
10	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
11	EDNRA	endothelin receptor type A	11.0	Publications
12	KRT7	keratin 7	11.0	Publications
13	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
14	EDN1	endothelin 1	11.0	Publications
15	WFDC2	WAP four-disulfide core domain 2	11.0	Publications
16	FOLR1	folate receptor 1 (adult)	11.0	Publications
17	MSLN	mesothelin	11.0	Functions, Publications
18	KLK8	kallikrein-related peptidase 8	11.0	Publications, Expressions
19	IP6K2	inositol hexakisphosphate kinase 2	11.0	Publications
20	MSBP1	minisatellite binding protein 1	11.0	Publications
21	KLK7	kallikrein-related peptidase 7	11.0	Expressions, Publications, Proteins
22	SPA17	sperm autoantigenic protein 17	11.0	Publications
23	SCGB2A1	secretoglobin, family 2A, member 1	11.0	Publications
24	SNCG	synuclein, gamma (breast cancer-specific protein 1)	11.0	Publications
25	DHDH	dihydrodiol dehydrogenase (dimeric)	11.0	Publications
26	SLC31A1	solute carrier family 31 (copper transporters), member 1	11.0	Publications
27	TACSTD2	tumor-associated calcium signal transducer 2	11.0	Publications
28	KLK10	kallikrein-related peptidase 10	11.0	Publications
29	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
30	KLK4	kallikrein-related peptidase 4	11.0	Publications
31	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0	Publications
32	KLK6	kallikrein-related peptidase 6	11.0	Publications
33	IL24	interleukin 24	11.0	Publications
34	MVP	major vault protein	11.0	Publications
35	PIP	prolactin-induced protein	11.0	Publications
36	RPSA	ribosomal protein SA	11.0	Publications
37	CLDN4	claudin 4	11.0	Publications
38	CSTA	cystatin A (stefin A)	11.0	Publications
39	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
40	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	11.0	Publications
41	ETV4	ets variant 4	11.0	Publications
42	KRT4	keratin 4	11.0	Publications
43	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0	Publications
44	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0	Publications
45	CLDN3	claudin 3	11.0	Publications
46	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
47	ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2	11.0	Publications
48	BRCA1	breast cancer 1, early onset	11.0	Publications
49	FST	follistatin	11.0	Publications
50	PAEP	progestagen-associated endometrial protein	11.0	Publications

Pathways related to ovarian carcinoma according to GeneDecks:

(show top 50)    (show all 312)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	22.7	PIP, PIK3CG, RB1, BRCA1, VEGFC, MYC
2	Pancreatic Adenocarcinoma36	18.7	KIT, RB1, BRAF, BRCA2, VEGFC, BMP4
3	p53 Mediated Apoptosis36	15.7	KIT, VEGFC, BMP4, BMP6, BMP7, BID
4	DHA Signaling36	15.3	KIT, VEGFC, BMP4, BMP6, BMP7, BID
5	eNOS Signaling36	15.2	KIT, BMP6, BMP7, MST1R, FLT4, AREG
6	Telomerase Components in Cell Signaling36	14.8	KIT, RB1, VEGFC, MYC, BMP4, BMP6
7	Transendothelial Migration of Leukocytes36	14.7	CLDN4, CLDN7, CLDN3, PAK1, BCAR1, LAMA5
8	Prostate cancer20	14.6	PIK3CA, PIK3CG, RELA, RB1, BRAF, RAF1
9	Nuclear Receptor Activation by Vitamin-A36	14.4	KIT, VEGFC, BMP4, BMP6, BMP7, RARG
10	Melanoma20	14.1	PIK3CA, PIK3CG, RB1, BRAF, RAF1, CDK6
11	Chronic myeloid leukemia20	14.0	PIK3CA, PIK3CG, RELA, RB1, BRAF, MYC
12	Cell adhesion ECM remodeling10	13.6	VTN, SERPINE1, MSN, CD44, ITGA1, ITGA5
13	Development VEGF-family signaling10	13.6	PIK3CA, VTN, VEGFC, RAF1, KDR, L1CAM
14	Development_VEGF signaling via VEGFR2 - generic cascades41	13.5	PIK3CA, RELA, VEGFA, RAF1, PAK1, JUN
15	Development_HGF signaling pathway41	13.3	PIK3CA, RAF1, JUN, CDH1, FOS, MET
16	Development Thrombopoietin-regulated cell processes10	13.2	PIK3CA, BRAF, MYC, RAF1, BIRC5, JUN
17	Immune response IL-2 activation and signaling pathway10	13.0	PIK3CA, REL, MYC, RAF1, JUN, FOS
18	Cell adhesion_PLAU signaling41	13.0	PIK3CA, VTN, SERPINE1, RAF1, BCAR1, ITGB1
19	Development Neurotrophin family signaling10	12.8	PIK3CA, BRAF, RAF1, BAX, XIAP, JUN
20	Development_ERBB-family signaling41	12.8	PIK3CA, REL, RAF1, FOS, AREG, MAPK3
21	TNF Superfamily Pathway36	12.8	JUN, FOS, MAPK8, MAP2K6, MAP2K3, MAP2K4
22	Acute myeloid leukemia20	12.7	PIK3CA, PIK3CG, KIT, BRAF, MYC, RARA
23	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	12.6	RELA, MYC, RAF1, BCL2, BAX, JUN
24	Development Growth hormone signaling via PI3K/AKT and MAPK cascades10	12.5	PIK3CA, RAF1, MTOR, CEBPB, JUN, JAK2
25	Development_Flt3 signaling41	12.4	PIK3CA, PAK1, JUN, MAPK8, MAP2K6, MAP2K3
26	Translation _Regulation of EIF4F activity41	12.4	PIK3CA, PAK1, MTOR, IRS1, MAP2K6, MAP2K3
27	Apoptosis and survival_TNFR1 signaling pathway41	12.1	REL, RELA, BID, BCL2, BAX, XIAP
28	Natural killer cell mediated cytotoxicity20	12.1	PIK3CA, PIK3CG, BRAF, RAET1E, RAF1, BID
29	MIF Regulation of Innate Immune Cells36	12.1	PIP, BMP4, BMP6, BMP7, LIF, BCL2
30	TNF-Induced Apoptosis Implicating Sphingolipids36	12.0	RAF1, BAX, MAPK8, MAP2K6, MAP2K3, MAP2K4
31	Immune response Oncostatin M signaling via MAPK in human cells10	11.8	RAF1, CEBPB, JUN, MMP1, MMP13, FOS
32	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	11.7	RELA, BAX, JUN, IL2, IL8, APAF1
33	TGF-beta signaling pathway20	11.7	RBL2, MYC, BMP4, BMP6, BMP7, ZFYVE9
34	Apoptosis and survival_Caspase cascade41	11.6	BID, PARP1, BAX, XIAP, IRS1, APAF1
35	T cell receptor signaling pathway20	11.6	PIK3CA, PIK3CG, RELA, RAF1, PAK1, JUN
36	Fc epsilon RI signaling pathway20	11.5	PIK3CA, PIK3CG, IL4, MAP2K6, MAP2K3, MAP2K4
37	Hematopoietic cell lineage20	11.3	KIT, CD24, CD36, CD44, CD9, ITGA1
38	Immune response_IL-1 signaling pathway41	11.0	RELA, SERPINE1, UBC, JUN, FOS, FOSB
39	Immune response_MIF-mediated glucocorticoid regulation41	10.0	REL, RELA, JUN, MMP1, FOS, IL2
40	IL-2 Pathway36	INF	MYC, RAF1, JUN, FOS, IL2, IL2RB
41	Rap1 Pathway36	INF	BRAF, VEGFC, BMP4, BMP6, BMP7, RAF1
42	HMGB1 Pathway36	INF	JUN, FOS, IL1A, IL1B, MAPK8, MAP2K6
43	EGF Pathway36	INF	BRAF, MYC, RAF1, PAK1, MUC1, JUN
44	HGF Pathway36	INF	RB1, RAF1, PAK1, JUN, CDK6, CDKN1B
45	MAPK signaling pathway20	INF	RELA, BRAF, MYC, RAF1, PAK1, JUN
46	p38 Signaling36	INF	PIP, KIT, VEGFC, BMP4, BMP6, BMP7
47	PAK Pathway36	INF	PIP, KIT, VEGFC, BMP4, BMP6, BMP7
48	p70S6K Signaling36	INF	KIT, VEGFC, BMP4, BMP6, BMP7, RAF1
49	Paxillin Interactions36	INF	KIT, VEGFC, BMP4, PAK1, KDR, BCAR1
50	eIF2 Pathway36	INF	KIT, BRAF, VEGFC, BMP4, BMP6, BMP7

Compounds related to ovarian carcinoma according to GeneDecks:

(show top 50)    (show all 455)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	39.1	PIKFYVE, PI3, RECK, REL, RELA, KIT
2	progesterone32 42 9 18 9	34.1	PIP, PIK3CA, KIT, KISS1, PCNA, RB1
3	dexamethasone32 42 34 9 9	33.4	PIK3CA, PI3, REL, VTN, PCNA, RB1
4	paclitaxel32 34 9 9	32.0	PIK3CA, PIK3CG, KIT, PCNA, BUB1B, RB1
5	atp32	26.9	PIKFYVE, PIK3CA, RECK, KIT, VTN, RB1
6	cysteine32	25.6	PI3, RECK, REL, VTN, PCNA, RBP4
7	cyclosporin a32 42	20.3	PIK3CA, PIK3CG, PI3, RECK, REL, BSG
8	forskolin32 42 9 9	22.3	VIM, BRAF, BMP4, BMP6, RARS, RARB
9	glucose32	18.5	PIKFYVE, KIT, KISS1, SETD2, BRAF, VHL
10	heparin32 9 18 9	21.5	PIK3CA, PIK3CG, RECK, VTN, SERPINE1, SERPINA3
11	flavopiridol32 9 9	18.3	PIK3CG, KIT, RB1, VEGFA, BID, BIRC5
12	thapsigargin32 42	16.9	PIK3CG, PCNA, SERPINE1, LPAR3, RAF1, BCL2
13	gf 109203x32 42	16.4	PIK3CG, VEGFA, RAF1, JUN, JAK2, CDKN1A
14	acetylcholine32 9 18 9	18.2	SERPINA3, VIM, BMP6, RAF1, LIF, PAK1
15	methotrexate32 34 42 9 9	18.9	KIT, PCNA, RB1, SERPINE1, SERPINA3, VIM
16	sucrose32 9 18 9	17.6	RECK, RBP4, BSG, RAD51, RARA, BCHE
17	erlotinib32 34 9 9	17.6	PIK3CA, KIT, VEGFA, BIRC5, KDR, MTOR
18	glycerol32 9 18 9	17.5	PCNA, BRCA1, PAEP, UGCG, CDK2, CD36
19	crcs32	14.1	PIK3CA, RB1, BRAF, RASSF1, BIRC5, MUC1
20	latex32	14.0	VTN, RBP4, LIF, LGALS3, CHEK2, LAMP1
21	histidine32	13.9	VHL, RAD51, RARA, LGALS1, CDKN2A, CD44
22	phosphatidylserine32 9 9	15.9	RECK, VIM, BID, PARP1, BCL2, LGALS1
23	ionomycin32	13.8	SETD2, SERPINA3, CDK6, CD274, CDK4, CD40
24	heparan sulfate32 18	14.8	VTN, SERPINE1, VIM, BSG, BMP4, BMP6
25	b 72332	13.8	PIP, PCNA, VIM, CHKA, MUC1, MUC16
26	guanine32 9 18 9	16.7	SETD2, BRCA1, VDR, RAD51, RAF1, BIRC5
27	p00332	13.5	KIT, RB1, SERPINE1, BRCA1, BRCA2, RASSF1
28	mannose 6-phosphate32 18	14.5	RECK, SELL, BMP6, LIF, LAMP1, FUCA1
29	tetracycline32 9 9	15.3	RB1, SAT1, CDK2, CDKN2A, CDKN1C, MMP1
30	fmlp32	13.2	PIK3CG, SELL, SERPINA3, VIM, LIF, CLEC3B
31	aprotinin32 9 9	15.1	MMP13, MMP2, MMP9, FN1, IL1A, MAP2K1
32	mitoxantrone32 9 9	14.9	BIRC5, BCL2, MVP, MTOR, IL3, FASLG
33	radicicol32 42 9 9	15.7	PIK3CG, VEGFA, RAF1, JUN, AR, GSN
34	4-hydroxynonenal32 18	13.4	MYC, PARP1, CHKA, BAX, JUN, CDK2
35	neomycin32	12.4	VIM, CEACAM5, CDKN2A, GRP, IL13, IL1A
36	pdtc32	12.4	PIK3CA, PIK3CG, SETD2, SERPINB5, RAF1, BIRC5
37	sulindac sulfide32	12.4	PCNA, BMP6, BCL2, BCL2L1, BAX, JUN
38	manumycin32	11.8	RAF1, INSR, ANXA5, MAPK8, MAPK14, MAP2K1
39	metformin32 34 9 9	14.7	PIK3CA, PIK3CG, SERPINE1, MTHFR, CGA, IRS1
40	hydrocortisone32 9 9	13.6	VIM, BMP6, LIF, KDR, MUC1, CD36
41	ifosfamide32 9 9	13.4	B2M, CGA, CGB, MGMT, GSTM1, GSTP1
42	salicylic acid32	11.3	PIK3CG, VDR, MYC, BCL2L1, CEBPB, CD40
43	uric acid32 18	11.8	RBP4, SERPINE1, LGALS1, CHKA, MTHFR, CD9
44	diphenyleneiodonium32	10.6	SETD2, VEGFA, JUN, CDKN3, INSR, IL1B
45	polyinosinic-polycytidylic acid32	9.9	CD83, CD40, IRF1, IL10, IL15, IL18
46	tarc32	9.8	CDH1, IL10, IL13, IL18, IL1A, IL4
47	pentoxifylline32 9 9	11.6	SELL, BMP6, CD9, MMP1, MMP2, IL10
48	gm-csf32	9.5	VEGFA, BMP6, LIF, BCL2L1, IL10, IL11
49	dextran sulfate32	9.4	VTN, SELL, JAK2, CD36, CD44, CD9
50	prednisolone32 9 9	10.6	SELL, MYC, BMP6, MVP, CDKN3, CD40

Cellular components related to ovarian carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	PIK3CG, RECK, KIT, KISS1R, VTCN1, SELL
2	nucleus	GO:005634	35.7	NDN, PDCD4, PDCD5, RELA, KIT, PCNA
3	cytoplasm	GO:005737	31.3	PIK3CG, PDCD4, PDCD5, RELA, KIT, PCNA
4	cytosol	GO:005829	26.3	PIKFYVE, PIK3CA, PIK3CG, NDN, PDCD4, REL
5	nucleoplasm	GO:005654	19.9	REL, RELA, REV1, PCNA, RB1, RBL2
6	extracellular region	GO:005576	19.5	PIP, KISS1, VTN, SEMA3B, SERPINE1, SERPINA3
7	cell surface	GO:009986	15.3	KISS1R, VEGFA, LPAR2, RARA, LGALS1, MSN
8	extracellular space	GO:005615	15.1	KIT, VTN, RBP4, SERPINB5, SERPINE1, VEGFA
9	perinuclear region of cytoplasm	GO:048471	14.9	PIKFYVE, BUB1B, RAD51, CLU, PARK2, BAG1
10	membrane raft	GO:045121	12.7	PIKFYVE, BSG, JAK2, CD24, CD36, ITGA1
11	external side of plasma membrane	GO:009897	12.4	KIT, SELL, KDR, LAMP1, B2M, CD36
12	platelet alpha granule lumen	GO:031093	10.6	SERPINE1, VEGFA, VEGFC, CLU, FN1, FIGF
13	integral to plasma membrane	GO:005887	INF	LRRC32, SELL, LPAR2, LPAR3, CLDN4, CLDN3

Biological processes related to ovarian carcinoma according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	20.9	KIT, VEGFC, VDR, RARA, RARB, RAF1
2	apoptotic process	GO:006915	18.6	PDCD4, PDCD5, BUB1B, VIM, BRCA1, BRMS1
3	positive regulation of cell proliferation	GO:008284	17.9	KIT, NACC1, VEGFA, VEGFC, MYC, RARA
4	cell proliferation	GO:008283	16.2	PCNA, BUB1B, RAF1, BCAR1, BCL2L1, BAK1
5	negative regulation of cell proliferation	GO:008285	16.0	NDN, KISS1R, VHL, VDR, BMP4, RARG
6	response to drug	GO:042493	15.6	VEGFC, MYC, PARK7, BCHE, BCL2, UQCRFS1
7	positive regulation of transcription, DNA-dependent	GO:045893	15.6	REL, RELA, RB1, BRCA1, BRCA2, VHL
8	angiogenesis	GO:001525	15.4	PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
9	blood coagulation	GO:007596	15.1	PIK3CA, PIK3CG, SELL, SERPINE1, BSG, VEGFA
10	virus-host interaction	GO:019048	15.0	RELA, RB1, VIM, BNIP3, RAN, KDR
11	negative regulation of apoptotic process	GO:043066	14.8	PIK3CG, RELA, SERPINE1, BRAF, VEGFA, MYC
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.6	RELA, RB1, SERPINE1, BRCA1, VEGFA, VDR
13	negative regulation of transcription from RNA polymerase II promoter	GO:000122	14.3	VHL, VDR, MYC, BMI1, BMP4, RARG
14	response to hypoxia	GO:001666	14.2	VEGFA, BNIP3, RAF1, CLDN3, PAK1, BCL2
15	nerve growth factor receptor signaling pathway	GO:048011	13.9	PIK3CA, NDN, RELA, BRAF, RAF1, BCAR1
16	heart development	GO:007507	13.9	PCNA, RBP4, RAF1, CASP7, CASP3, CASP8
17	negative regulation of transcription, DNA-dependent	GO:045892	13.7	PDCD4, RELA, RB1, NACC1, BRCA1, BRMS1
18	anti-apoptosis	GO:006916	13.7	PIK3CA, RELA, BRAF, VHL, BNIP3, BIRC5
19	protein autophosphorylation	GO:046777	13.6	KIT, PAK1, KDR, CHEK2, MTOR, AURKA
20	response to estradiol stimulus	GO:032355	13.4	BRCA2, VDR, BMP4, RARA, BID, AURKA
21	cell-cell signaling	GO:007267	13.4	SEMA3B, CGA, CGB, CD86, CD80, AR
22	induction of apoptosis	GO:006917	13.3	PDCD5, NACC1, BNIP3, BAX, CEBPB, CDKN1B
23	positive regulation of apoptotic process	GO:043065	13.3	BMP4, RARG, RARB, BID, CLU, BAK1
24	response to organic cyclic compound	GO:014070	13.2	BMP4, BAK1, MSH2, JUN, CDKN1A, CD83
25	epidermal growth factor receptor signaling pathway	GO:007173	13.2	PIK3CA, RAF1, BCAR1, UBC, MTOR, CDKN1B
26	induction of apoptosis by intracellular signals	GO:008629	13.2	BNIP3, MYC, BID, CLU, BCL2, BCL2L1
27	response to lipopolysaccharide	GO:032496	13.2	CEBPB, JUN, JAK2, MMP9, IL13, IL1A
28	positive regulation of gene expression	GO:010628	13.0	LRRC32, KIT, BRAF, VEGFA, VDR, CDK1
29	phosphatidylinositol-mediated signaling	GO:048015	12.9	PIK3CA, PCNA, BUB1B, MTOR, AURKA, CDKN1B
30	cell cycle arrest	GO:007050	12.8	RB1, MYC, RASSF1, MSH2, CDK6, CDKN1A
31	positive regulation of angiogenesis	GO:045766	12.8	SERPINE1, VEGFA, KDR, MTDH, MMP9, FLT1
32	positive regulation of protein phosphorylation	GO:001934	12.8	VEGFA, BMP4, MTOR, AXIN1, CD40, FLT4
33	cellular response to mechanical stimulus	GO:071260	12.6	BNIP3, BAK1, CD40, ITGB1, IRF1, IL13
34	aging	GO:007568	12.6	VDR, BAK1, JUN, GSN, IL15, IL1B
35	regulation of cell proliferation	GO:042127	12.5	KIT, SERPINE1, BRCA1, BID, BIRC7, SCGB3A1
36	positive regulation of protein kinase B signaling cascade	GO:051897	12.4	PIK3CG, MTDH, MTOR, MST1R, INSR, ILK
37	response to ethanol	GO:045471	12.3	RBP4, BCL2, BAK1, CDK1, MMP9, INSR
38	platelet activation	GO:030168	12.1	PIK3CA, PIK3CG, SERPINE1, VEGFA, VEGFC, RAF1
39	positive regulation of cell division	GO:051781	12.0	VEGFA, VEGFC, FIGF, FGF2, IL1A, IL1B
40	activation of MAPK activity	GO:000187	12.0	KIT, LPAR2, LPAR3, UBC, CDK1, ITGA1
41	peptidyl-tyrosine phosphorylation	GO:018108	11.9	KIT, KDR, JAK2, FLT1, FLT4, INSR
42	positive regulation of MAP kinase activity	GO:043406	11.7	PIK3CG, VEGFA, MST1R, CD24, CD40, FLT1
43	positive regulation of peptidyl-serine phosphorylation	GO:033138	11.6	PIK3CA, BRAF, VEGFA, RAF1, LIF, PAK1
44	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.6	VTN, VEGFA, LIF, MTOR, JAK2, CD36
45	positive regulation of MAPK cascade	GO:043410	11.4	KIT, LPAR2, LPAR3, LIF, KDR, CD36
46	inflammatory response	GO:006954	11.2	PIK3CG, RELA, KIT, SERPINA3, BMP6, PARK7
47	positive regulation of smooth muscle cell proliferation	GO:048661	10.7	BMP4, JUN, CDH13, MNAT1, FLT1, IL13
48	platelet degranulation	GO:002576	10.2	SERPINE1, VEGFA, VEGFC, CLU, CD36, CD9
49	cell adhesion	GO:007155	INF	VTN, SELL, BCAR1, LGALS3BP, CHL1, MUC16
50	positive regulation of cell migration	GO:030335	INF	VEGFA, KDR, BCAR1, CGA, JAK2, CDH13

Molecular functions related to ovarian carcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	21.9	PIKFYVE, PIK3CA, PIK3CG, KIT, BUB1B, BRAF
2	sequence-specific DNA binding transcription factor activity	GO:003700	16.6	REL, RELA, RB1, VDR, MYC, MYCL1
3	protein homodimerization activity	GO:042803	16.0	KIT, VEGFA, BNIP3, BMP4, BIRC5, PARK7
4	sequence-specific DNA binding	GO:043565	15.6	VDR, MYC, RARG, RARA, RARB, BCL2
5	identical protein binding	GO:042802	15.2	RELA, PCNA, PCM1, VIM, BNIP3, RAD51
6	enzyme binding	GO:019899	14.4	BRCA1, VHL, RARA, BIRC5, BIRC7, BCHE
7	protein heterodimerization activity	GO:046982	14.3	BRAF, VEGFA, BNIP3, MYC, BMP6, RARA
8	transcription factor binding	GO:008134	14.3	RELA, RB1, VHL, MYC, RARA, PARP1
9	protein kinase binding	GO:019901	14.0	RELA, VIM, PAK1, PARK2, BCAR1, BCL2L1
10	receptor binding	GO:005102	13.0	SERPINE1, RARA, LIF, MSN, JAK2, ITGB4
11	growth factor activity	GO:008083	12.6	VEGFA, VEGFC, BMP4, BMP6, BMP7, LIF
12	protein tyrosine kinase activity	GO:004713	11.9	KIT, KDR, JAK2, INSR, FGFR1, FGR
13	cytokine activity	GO:005125	10.9	VEGFA, BMP4, BMP6, BMP7, LIF, SCGB3A1
14	protein binding	GO:005515	INF	PIKFYVE, PIK3CA, PIK3CG, PDCD4, REL, RELA