MCID: OVR044
MIFTS: 48

Ovarian Carcinosarcoma malady

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Summaries for Ovarian Carcinosarcoma

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards: Ovarian Carcinosarcoma, also known as malignant mixed mullerian tumor of the ovary, is related to malignant mixed mullerian tumor and breast cancer. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Cytoskeleton remodeling Keratin filaments. The compounds azd 2171 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and small intestine, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Ovarian Carcinosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian carcinosarcoma 8 43 62
malignant mixed mullerian tumor of the ovary 43
ovarian malignant mesodermal mixed tumor 8
ovarian malignant mixed mullerian tumor 8
malignant mixed mesodermal tumor 62
ovarian mmmt 8


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Disease Ontology8 DOID:6170
NCIt40 C9192

Related Diseases for Ovarian Carcinosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mixed mullerian tumor31.0VIM, PGR
2breast cancer30.4TUBB3, MKI67, VEGFA, ERBB2, PGR, FLT4
3cystadenocarcinoma30.3MUC1
4angiosarcoma30.2VIM, FLT4, MUC1
5melanoma30.0VIM, MKI67, VEGFA, FLT4
6bilateral breast cancer10.5
7pancreatitis10.4
8malignant mixed epithelial mesenchymal tumor of the ovary10.3
9hidradenoma10.1MUC1
10hydrocele10.1FLT4
11lymphangiosarcoma10.1F8
12syringoma10.1MUC1
13serous cystadenocarcinoma10.1
14thromboembolism10.1
15kidney cancer10.1VEGFA
16breast fibroadenoma10.1PGR
17adenosarcoma10.1PGR
18central retinal vein occlusion10.1VEGFA
19adenomatoid tumor10.1VIM
20glomus tumor10.1VIM
21lymphangioma10.1F8, FLT4
22vascular cancer10.1FLT4, VEGFA
23sertoli-leydig cell tumor10.1MUC1, PGR
24primary hyperoxaluria10.1F8, VEGFA
25secretory meningioma10.1MUC1, VIM
26clear cell ependymoma10.1MUC1, VIM
27meningioma10.1MKI67, PGR
28hemangioblastoma10.1VEGFA, MUC1
29mesenchymal chondrosarcoma10.1MUC1, VIM
30epithelioid sarcoma10.0MUC1, VIM
31mucoepidermoid carcinoma10.0MUC1, MKI67
32dermatofibrosarcoma protuberans10.0VIM, MUC1
33perineurioma10.0VIM, MUC1
34rhabdoid tumor10.0VIM, MUC1
35adenosquamous carcinoma10.0MUC1, PGR
36benign meningioma10.0MKI67, PGR
37laryngeal benign neoplasm10.0FLT4, MKI67
38chordoma10.0VIM, MUC1
39malignant peripheral nerve sheath tumor10.0MUC1, VIM
40giant cell tumor10.0MUC1, VIM
41abrikosov's tumor10.0VIM, MUC1
42endometrial stromal sarcoma10.0VIM, PGR
43cutaneous paget's disease10.0ERBB2, MUC1
44hemangioma10.0FLT4, VEGFA, F8
45angiomyolipoma10.0VIM, PGR
46neurofibroma10.0VIM, MUC1
47fibromatosis10.0VIM, PGR
48oxyphilic adenoma10.0MUC1, VIM
49spindle cell sarcoma10.0VIM, FLT4, MUC1
50laryngeal squamous cell carcinoma10.0MKI67, VEGFA, FLT4

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Symptoms for Ovarian Carcinosarcoma

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Drugs & Therapeutics for Ovarian Carcinosarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Ovarian Carcinosarcoma

Search NIH Clinical Center for Ovarian Carcinosarcoma

Genetic Tests for Ovarian Carcinosarcoma

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Anatomical Context for Ovarian Carcinosarcoma

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33MalaCards
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MalaCards organs/tissues related to Ovarian Carcinosarcoma:

33
Ovary, Small intestine

Animal Models for Ovarian Carcinosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0VEGFA, PGR, MUC1, ERBB2, TACSTD2
2MP:00107717.8VEGFA, PGR, FLT4, MUC1, ERBB2, TACSTD2
3MP:00053697.6VEGFA, PGR, FLT4, VIM, ERBB2
4MP:00053857.6ERBB2, VIM, FLT4, PGR, VEGFA
5MP:00028737.6VEGFA, PGR, FLT4, MUC1, ERBB2
6MP:00053807.5VEGFA, PGR, FLT4, VIM, ERBB2, TACSTD2
7MP:00053897.3VEGFA, PGR, FLT4, VIM, F8, ERBB2
8MP:00053847.3TUBB3, VEGFA, PGR, VIM, ERBB2, TACSTD2
9MP:00107686.8TUBB3, VEGFA, PGR, FLT4, VIM, F8
10MP:00053766.8TACSTD2, VEGFA, PGR, FLT4, VIM, MUC1

Publications for Ovarian Carcinosarcoma

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52PubMed
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Articles related to Ovarian Carcinosarcoma:

(show all 26)
idTitleAuthorsYear
1
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
2
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
3
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
4
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
5
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
6
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
7
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
8
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
9
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
10
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
11
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
12
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
13
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
14
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
15
Current management of ovarian carcinosarcoma. (17362309)
2007
16
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
17
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
18
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
19
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
20
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
21
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
22
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
23
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
24
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
25
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
26
MR images of ovarian carcinosarcoma. (10646984)
1999

Variations for Ovarian Carcinosarcoma

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Expression for genes affiliated with Ovarian Carcinosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Carcinosarcoma

Search GEO for disease gene expression data for Ovarian Carcinosarcoma.

Pathways for genes affiliated with Ovarian Carcinosarcoma

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50PathCards, 55Reactome, 60Thomson Reuters, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database
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Pathways related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FLT4, VEGFA
29.5VIM, TUBB3
3
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.8ERBB2, FLT4, VEGFA
48.5VEGFA, VIM, ERBB2
5
Show member pathways
8.0ERBB2, MUC1, VIM, FLT4, TUBB3
6
Show member pathways
7.9TUBB3, VEGFA, PGR, FLT4, ERBB2

Compounds for genes affiliated with Ovarian Carcinosarcoma

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1azd 2171459.8FLT4, VEGFA
2hematoxylin459.2MUC1, VIM, MKI67
3sunitinib45 51 1111.1VEGFA, FLT4, ERBB2
4anastrozole45 51 1111.1MKI67, PGR, ERBB2
5fulvestrant45 51 29 1112.0MKI67, PGR, ERBB2
6letrozole45 51 61 1112.0MKI67, PGR, ERBB2
7capecitabine45 51 1111.0ERBB2, PGR, VEGFA
8mifepristone45 29 61 1112.0MKI67, VEGFA, PGR, MUC1
9taxane459.0VEGFA, PGR, ERBB2
10dmso458.9TUBB3, PGR, VIM, MUC1
11matrigel458.9VEGFA, FLT4, VIM, MUC1
12leucovorin45 51 1110.8VEGFA, PGR, ERBB2
13vinorelbine45 51 1110.8TUBB3, MKI67, VEGFA, ERBB2
14irinotecan45 51 1110.8ERBB2, VEGFA, MKI67, TUBB3
15celecoxib45 61 29 51 24 1113.7ERBB2, VEGFA, MKI67
16docetaxel45 51 61 1111.7TUBB3, VEGFA, PGR, ERBB2
17trastuzumab45 51 1110.7VEGFA, PGR, MUC1, ERBB2
18biotin45 24 1110.6MKI67, VIM, MUC1, ERBB2
194-hydroxytamoxifen458.6PGR, VIM, ERBB2
20polyethylene glycol458.6MUC1, F8, ERBB2
21formaldehyde45 249.5MKI67, VIM, MUC1, ERBB2
22adriamycin458.5ERBB2, MUC1, VIM, PGR
23estradiol45 24 1110.5F8, MUC1, VIM, PGR, MKI67
24agar458.4PGR, VIM, MUC1, ERBB2
25gefitinib45 51 1110.4ERBB2, VIM, VEGFA
26gnrh458.3ERBB2, VIM, PGR, MKI67
27cisplatin45 51 61 1111.3TUBB3, MKI67, VEGFA, MUC1, ERBB2
28rapamycin458.3VEGFA, FLT4, VIM, ERBB2
29retinoic acid45 249.2TUBB3, MKI67, PGR, FLT4, VIM, MUC1
305fluorouracil458.2MKI67, VEGFA, PGR, MUC1, ERBB2
31cyclophosphamide45 51 1110.2ERBB2, F8, PGR, VEGFA, MKI67
32thymidylate458.2TUBB3, MKI67, VEGFA, VIM, ERBB2
33aspartate458.1TACSTD2, ERBB2, F8, VIM, PGR
34folate458.1MKI67, PGR, VIM, MUC1, ERBB2
35methotrexate51 45 1110.1MKI67, PGR, VIM, MUC1, ERBB2
36genistein45 29 61 3 24 1113.0ERBB2, VIM, PGR, VEGFA
37testosterone45 61 24 1110.9ERBB2, MUC1, VIM, PGR, MKI67
38doxorubicin45 51 119.9MKI67, VEGFA, PGR, VIM, ERBB2
39alanine457.9TACSTD2, ERBB2, F8, VIM, PGR
40cycloheximide457.8MKI67, VEGFA, PGR, VIM, ERBB2
41progesterone45 29 61 24 1111.7MKI67, PGR, VIM, MUC1, F8, ERBB2
42progestin457.7VEGFA, PGR, VIM, MUC1, F8, ERBB2
43serine457.6TUBB3, MKI67, VIM, MUC1, F8, ERBB2
44tamoxifen45 51 29 1110.6MKI67, VEGFA, PGR, VIM, MUC1, ERBB2
45tyrosine457.6TUBB3, MKI67, VEGFA, FLT4, MUC1, F8
46paclitaxel45 51 119.3TUBB3, MKI67, VEGFA, PGR, FLT4, VIM
47dexamethasone45 51 29 1110.3VEGFA, PGR, FLT4, VIM, MUC1, F8
48paraffin457.3MKI67, VEGFA, PGR, FLT4, VIM, MUC1
49vegf456.8MKI67, VEGFA, PGR, FLT4, VIM, MUC1
50estrogen456.5ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

GO Terms for genes affiliated with Ovarian Carcinosarcoma

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16Gene Ontology
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Cellular components related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5F8, VEGFA
2cytoplasmGO:0057376.7ERBB2, MUC1, VIM, FLT4, VEGFA, MKI67

Biological processes related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.8PGR, TACSTD2
2positive regulation of protein kinase C signalingGO:0900379.8VEGFA, FLT4
3cellular response to vascular endothelial growth factor stimulusGO:0359249.8FLT4, VEGFA
4vascular endothelial growth factor receptor signaling pathwayGO:0480109.7FLT4, VEGFA
5positive regulation of endothelial cell migrationGO:0105959.6VEGFA, FLT4
6positive regulation of cell adhesionGO:0457859.2VEGFA, ERBB2
7positive regulation of epithelial cell proliferationGO:0506799.1ERBB2, VEGFA
8positive regulation of MAP kinase activityGO:0434069.0ERBB2, VEGFA
9positive regulation of protein phosphorylationGO:0019349.0ERBB2, FLT4, VEGFA
10cell proliferationGO:0082838.6TACSTD2, ERBB2, MKI67

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.3ERBB2, FLT4
2growth factor bindingGO:0198389.0ERBB2, FLT4
3protein C-terminus bindingGO:0080228.5MKI67, VIM, ERBB2
4protein bindingGO:0055156.1ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

Products for genes affiliated with Ovarian Carcinosarcoma

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Sources for Ovarian Carcinosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet