MCID: OVR044
MIFTS: 41

Ovarian Carcinosarcoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Ovarian Carcinosarcoma

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Ovarian Carcinosarcoma, Aliases & Descriptions:

Name: Ovarian Carcinosarcoma 9 41 60
Malignant Mixed Mullerian Tumor of the Ovary 41
Ovarian Malignant Mesodermal Mixed Tumor 9
 
Ovarian Malignant Mixed Mullerian Tumor 9
Ovarian Mmmt 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology9 DOID:6170
NCIt38 C9192

Summaries for Ovarian Carcinosarcoma

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NIH Rare Diseases:41 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards based summary: Ovarian Carcinosarcoma, also known as malignant mixed mullerian tumor of the ovary, is related to malignant mixed mullerian tumor and cystadenocarcinoma. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Cytoskeleton remodeling Keratin filaments. The compounds azd 2171 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and small intestine, and related mouse phenotypes are tumorigenesis and integument.

Related Diseases for Ovarian Carcinosarcoma

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Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mixed mullerian tumor31.3VIM, PGR
2cystadenocarcinoma31.0MUC1
3breast cancer30.8PGR, ERBB2
4angiosarcoma30.3FLT4, VIM, MUC1
5melanoma29.7MKI67, VEGFA, FLT4, VIM
6hidradenoma10.5MUC1
7hydrocele10.5FLT4
8classic kaposi sarcoma10.5F8
9syringoma10.5MUC1
10lymphangiosarcoma10.5F8
11bilateral breast cancer10.5
12renal cell carcinoma10.4VEGFA
13breast fibroadenoma10.4PGR
14adenosarcoma10.4PGR
15central retinal vein occlusion10.4VEGFA
16adenomatoid tumor10.4VIM
17pancreatitis10.4
18glomus tumor10.4VIM
19lymphangioma10.3FLT4, F8
20vascular cancer10.3VEGFA, FLT4
21malignant mixed epithelial mesenchymal tumor of the ovary10.3
22sertoli-leydig cell tumor10.3PGR, MUC1
23kidney disease10.2VEGFA, F8
24secretory meningioma10.2MUC1, VIM
25clear cell ependymoma10.2MUC1, VIM
26meningioma, familial10.2MKI67, PGR
27hemangioblastoma10.2MUC1, VEGFA
28mesenchymal chondrosarcoma10.2VIM, MUC1
29epithelioid sarcoma10.2VIM, MUC1
30mucoepidermoid carcinoma10.2MKI67, MUC1
31dermatofibrosarcoma protuberans10.2VIM, MUC1
32adenosquamous carcinoma10.2PGR, MUC1
33rhabdoid tumor10.2VIM, MUC1
34benign meningioma10.2PGR, MKI67
35perineurioma10.2VIM, MUC1
36laryngeal carcinoma10.2MKI67, FLT4
37chordoma10.2VIM, MUC1
38malignant peripheral nerve sheath tumor10.2VIM, MUC1
39abrikosov's tumor10.2VIM, MUC1
40giant cell tumor10.2VIM, MUC1
41endometrial stromal sarcoma10.1VIM, PGR
42paget disease, extramammary10.1ERBB2, MUC1
43angiomyolipoma10.1VIM, PGR
44hemangioma10.1VEGFA, FLT4, F8
45neurofibroma10.1VIM, MUC1
46serous cystadenocarcinoma10.1
47pleomorphic liposarcoma10.1
48liposarcoma10.1
49rhabdomyosarcoma10.1
50fibromatosis10.1VIM, PGR

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Symptoms for Ovarian Carcinosarcoma

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Drugs & Therapeutics for Ovarian Carcinosarcoma

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Drug clinical trials:

Search ClinicalTrials for Ovarian Carcinosarcoma

Search NIH Clinical Center for Ovarian Carcinosarcoma

Genetic Tests for Ovarian Carcinosarcoma

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Anatomical Context for Ovarian Carcinosarcoma

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MalaCards organs/tissues related to Ovarian Carcinosarcoma:

31
Ovary, Small intestine

Animal Models for Ovarian Carcinosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0VEGFA, PGR, MUC1, ERBB2, TACSTD2
2MP:00107717.8VEGFA, PGR, FLT4, MUC1, ERBB2, TACSTD2
3MP:00053697.6VEGFA, PGR, FLT4, VIM, ERBB2
4MP:00053857.6ERBB2, VIM, FLT4, PGR, VEGFA
5MP:00028737.6VEGFA, PGR, FLT4, MUC1, ERBB2
6MP:00053807.5VEGFA, PGR, FLT4, VIM, ERBB2, TACSTD2
7MP:00053897.3VEGFA, PGR, FLT4, VIM, F8, ERBB2
8MP:00053847.3TUBB3, VEGFA, PGR, VIM, ERBB2, TACSTD2
9MP:00107686.8TUBB3, VEGFA, PGR, FLT4, VIM, F8
10MP:00053766.8TACSTD2, VEGFA, PGR, FLT4, VIM, MUC1

Publications for Ovarian Carcinosarcoma

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Articles related to Ovarian Carcinosarcoma:

(show all 31)
idTitleAuthorsYear
1
Presence of both Mesenchymal and Carcinomatous Features in an In-vitro Model of Ovarian Carcinosarcoma Derived from Patients' Ascitic Fluid. (25802693)
2015
2
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. (24587930)
2014
3
A rare case of ovarian carcinosarcoma with neuroendocrine differentiation. (24971408)
2014
4
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Uterine and Ovarian Carcinosarcoma. (25341582)
2014
5
Radical surgical cytoreduction in the treatment of ovarian carcinosarcoma. (24631447)
2014
6
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
7
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
8
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
9
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
10
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
11
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
12
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
13
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
14
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
15
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
16
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
17
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
18
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
19
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
20
Current management of ovarian carcinosarcoma. (17362309)
2007
21
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
22
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
23
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
24
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
25
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
26
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
27
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
28
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
29
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
30
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
31
MR images of ovarian carcinosarcoma. (10646984)
1999

Variations for Ovarian Carcinosarcoma

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Expression for genes affiliated with Ovarian Carcinosarcoma

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Search GEO for disease gene expression data for Ovarian Carcinosarcoma.

Pathways for genes affiliated with Ovarian Carcinosarcoma

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Pathways related to Ovarian Carcinosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FLT4, VEGFA
29.5VIM, TUBB3
3
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.8ERBB2, FLT4, VEGFA
48.5VEGFA, VIM, ERBB2
5
Show member pathways
8.0ERBB2, MUC1, VIM, FLT4, TUBB3
6
Show member pathways
7.9TUBB3, VEGFA, PGR, FLT4, ERBB2

Compounds for genes affiliated with Ovarian Carcinosarcoma

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Compounds related to Ovarian Carcinosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1azd 2171439.8FLT4, VEGFA
2hematoxylin439.2MKI67, VIM, MUC1
3sunitinib43 49 1211.1ERBB2, VEGFA, FLT4
4anastrozole43 49 1211.1ERBB2, PGR, MKI67
5fulvestrant43 49 28 1212.0PGR, MKI67, ERBB2
6letrozole43 49 59 1212.0ERBB2, MKI67, PGR
7capecitabine43 49 1211.0VEGFA, ERBB2, PGR
8mifepristone43 28 59 1212.0MKI67, MUC1, PGR, VEGFA
9taxane439.0ERBB2, PGR, VEGFA
10dmso438.9PGR, MUC1, VIM, TUBB3
11matrigel438.9VIM, MUC1, FLT4, VEGFA
12leucovorin43 49 1210.8ERBB2, PGR, VEGFA
13vinorelbine43 49 1210.8ERBB2, TUBB3, VEGFA, MKI67
14irinotecan43 49 1210.8ERBB2, TUBB3, VEGFA, MKI67
15celecoxib43 59 28 49 24 1213.7MKI67, VEGFA, ERBB2
16docetaxel43 49 59 1211.7ERBB2, PGR, VEGFA, TUBB3
17trastuzumab43 49 1210.7VEGFA, PGR, ERBB2, MUC1
18biotin43 24 1210.6VIM, MKI67, MUC1, ERBB2
194-hydroxytamoxifen438.6VIM, PGR, ERBB2
20polyethylene glycol438.6F8, MUC1, ERBB2
21formaldehyde43 249.5VIM, MKI67, ERBB2, MUC1
22adriamycin438.5MUC1, ERBB2, VIM, PGR
23estradiol43 24 1210.5MUC1, F8, MKI67, VIM, PGR
24agar438.4PGR, VIM, MUC1, ERBB2
25gefitinib43 49 1210.4VEGFA, ERBB2, VIM
26gnrh438.3ERBB2, MKI67, PGR, VIM
27cisplatin43 49 59 1211.3TUBB3, MUC1, ERBB2, VEGFA, MKI67
28rapamycin438.3FLT4, VIM, VEGFA, ERBB2
29retinoic acid43 249.2MUC1, VIM, TUBB3, MKI67, PGR, FLT4
305fluorouracil438.2ERBB2, MUC1, PGR, VEGFA, MKI67
31cyclophosphamide43 49 1210.2F8, PGR, ERBB2, MKI67, VEGFA
32thymidylate438.2TUBB3, MKI67, VIM, ERBB2, VEGFA
33aspartate438.1F8, PGR, TACSTD2, VIM, ERBB2
34folate438.1VIM, ERBB2, MUC1, PGR, MKI67
35methotrexate49 43 1210.1ERBB2, MKI67, PGR, VIM, MUC1
36genistein43 28 59 2 24 1213.0ERBB2, VIM, PGR, VEGFA
37testosterone43 59 24 1210.9ERBB2, MKI67, PGR, VIM, MUC1
38doxorubicin43 49 129.9MKI67, VEGFA, PGR, VIM, ERBB2
39alanine437.9PGR, VIM, ERBB2, F8, TACSTD2
40cycloheximide437.8MKI67, PGR, VEGFA, VIM, ERBB2
41progesterone43 28 59 24 1211.7MUC1, F8, VIM, ERBB2, PGR, MKI67
42progestin437.7VIM, VEGFA, PGR, MUC1, ERBB2, F8
43serine437.6ERBB2, F8, MUC1, VIM, MKI67, TUBB3
44tamoxifen43 49 28 1210.6PGR, ERBB2, MUC1, VIM, VEGFA, MKI67
45tyrosine437.6MKI67, ERBB2, TUBB3, F8, MUC1, FLT4
46paclitaxel43 49 129.3PGR, VIM, FLT4, TUBB3, MKI67, ERBB2
47dexamethasone43 49 28 1210.3FLT4, PGR, VIM, F8, MUC1, VEGFA
48paraffin437.3ERBB2, MUC1, VIM, FLT4, PGR, VEGFA
49vegf436.8FLT4, PGR, VEGFA, MKI67, VIM, MUC1
50estrogen436.5VIM, F8, ERBB2, PGR, VEGFA, MKI67

GO Terms for genes affiliated with Ovarian Carcinosarcoma

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Cellular components related to Ovarian Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5F8, VEGFA
2cytoplasmGO:00057376.7ERBB2, MUC1, VIM, FLT4, VEGFA, MKI67

Biological processes related to Ovarian Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:00506789.8PGR, TACSTD2
2positive regulation of protein kinase C signalingGO:00900379.8VEGFA, FLT4
3cellular response to vascular endothelial growth factor stimulusGO:00359249.8FLT4, VEGFA
4vascular endothelial growth factor receptor signaling pathwayGO:00480109.7FLT4, VEGFA
5positive regulation of endothelial cell migrationGO:00105959.6VEGFA, FLT4
6positive regulation of cell adhesionGO:00457859.2VEGFA, ERBB2
7positive regulation of epithelial cell proliferationGO:00506799.1ERBB2, VEGFA
8positive regulation of MAP kinase activityGO:00434069.0ERBB2, VEGFA
9positive regulation of protein phosphorylationGO:00019349.0ERBB2, FLT4, VEGFA
10cell proliferationGO:00082838.6TACSTD2, ERBB2, MKI67

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.3ERBB2, FLT4
2growth factor bindingGO:00198389.0ERBB2, FLT4
3protein C-terminus bindingGO:00080228.5MKI67, VIM, ERBB2
4protein bindingGO:00055156.1ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

Products for genes affiliated with Ovarian Carcinosarcoma

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Sources for Ovarian Carcinosarcoma

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
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39NDF-RT
42NINDS
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
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61UMLS via Orphanet