MCID: OVR044
MIFTS: 44

Ovarian Carcinosarcoma malady

Cancer diseases category

Summaries for Ovarian Carcinosarcoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards: Ovarian Carcinosarcoma, also known as malignant mixed mullerian tumor of the ovary, is related to bilateral breast cancer and uterine carcinosarcoma. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Rho Family GTPases. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include ovary and small intestine, and related mouse phenotypes are homeostasis/metabolism and integument.

Aliases & Classifications for Ovarian Carcinosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian carcinosarcoma 8 42 60
malignant mixed mullerian tumor of the ovary 42
ovarian malignant mesodermal mixed tumor 8
ovarian malignant mixed mullerian tumor 8
malignant mixed mesodermal tumor 60
ovarian mmmt 8


External Ids:

Disease Ontology8 DOID:6170
NCIt39 C9192

Related Diseases for Ovarian Carcinosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1bilateral breast cancer30.6PGR
2uterine carcinosarcoma30.6ERBB2
3breast cancer30.5TUBB3, FLT4, VEGFA, MKI67, MUC1, PGR
4adenosarcoma30.4PGR
5malignant mixed mullerian tumor30.3PGR, VIM
6cystadenocarcinoma30.1MUC1
7angiosarcoma30.0VIM, FLT4, MUC1
8melanoma30.0VIM, FLT4, VEGFA, MKI67
9vaginal carcinosarcoma10.4
10pancreatitis10.3
11primitive neuroectodermal tumor10.3
12cervical carcinosarcoma10.3
13cystic teratoma10.3
14fallopian tube carcinosarcoma10.3
15malignant teratoma10.3
16malignant mixed epithelial mesenchymal tumor of the ovary10.2
17serous cystadenocarcinoma10.1
18ovarian serous cystadenocarcinoma10.1
19ovarian angiosarcoma10.1
20ovarian cystadenocarcinoma10.1
21cervical cancer10.0FLT4
22hemangioendothelioma10.0FLT4
23hepatitis10.0F8
24hidradenoma10.0MUC1
25syringoma10.0MUC1
26hepatitis c10.0F8
27kaposi's sarcoma10.0F8
28lymphangiosarcoma10.0F8
29oligodendroglioma10.0MKI67
30hepatitis b10.0F8
31hydrocele10.0FLT4
32gynecomastia10.0PGR
33kidney cancer10.0VEGFA
34lymphangioleiomyomatosis10.0PGR
35von hippel-lindau disease10.0VEGFA
36thromboembolism10.0F8
37adenomatoid tumor10.0VIM
38wilms tumor10.0VIM
39glomus tumor10.0VIM
40central retinal vein occlusion10.0VEGFA
41rhabdomyosarcoma10.0VIM
42laryngeal benign neoplasm10.0FLT4, MKI67
43liposarcoma10.0VIM
44blindness10.0VEGFA
45leukemia10.0FLT4, F8
46tuberous sclerosis10.0VIM
47stomach cancer10.0ERBB2
48hemangioblastoma10.0MUC1, VEGFA
49biliary tract neoplasm10.0ERBB2
50sertoli-leydig cell tumor10.0MUC1, PGR

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Clinical Features for Ovarian Carcinosarcoma

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Drugs & Therapeutics for Ovarian Carcinosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Ovarian Carcinosarcoma

Drug clinical trials:

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Genetic Tests for Ovarian Carcinosarcoma

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Anatomical Context for Ovarian Carcinosarcoma

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32MalaCards
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MalaCards organs/tissues related to Ovarian Carcinosarcoma:

32
Ovary, Small intestine

Animal Models for Ovarian Carcinosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4TACSTD2, PGR, F8
2MP:00107719.4TACSTD2, VEGFA
3MP:00053898.3ERBB2, VEGFA, FLT4, F8
4MP:00020067.6VEGFA, MUC1, PGR, TACSTD2, ERBB2
5MP:00053807.4VIM, FLT4, VEGFA, PGR, TACSTD2, ERBB2
6MP:00107686.6VIM, TUBB3, F8, FLT4, VEGFA, PGR

Publications for Ovarian Carcinosarcoma

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50PubMed
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Articles related to Ovarian Carcinosarcoma:

(show all 31)
idTitleAuthorsYear
1
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
2
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
3
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
4
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
5
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
6
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
7
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
8
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
9
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
10
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
11
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
12
Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report. (21639901)
2011
13
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
14
Prediction of Chemotherapy Response With Platinum and Taxane in the Advanced Stage of Ovarian and Uterine Carcinosarcoma: A Clinical Implication of In vitro Drug Resistance Assay. (19875949)
2010
15
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
16
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
17
Current management of ovarian carcinosarcoma. (17362309)
2007
18
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
19
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
20
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
21
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
22
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
23
Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. (12694655)
2003
24
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
25
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
26
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
27
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
28
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
29
MR images of ovarian carcinosarcoma. (10646984)
1999
30
Utility of immunohistochemistry in distinguishing ovarian sertoli-stromal cell tumors from carcinosarcomas. (1612579)
1992
31
Bilateral ovarian endometriosis associated with carcinosarcoma of the right ovary and endometrioid carcinoma of the left ovary. (707438)
1978

Genetic Variations for Ovarian Carcinosarcoma

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Expression for genes affiliated with Ovarian Carcinosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Carcinosarcoma

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Pathways for genes affiliated with Ovarian Carcinosarcoma

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53Reactome, 51QIAGEN
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Pathways related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3VEGFA, FLT4
2
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8.3ERBB2, MUC1, FLT4, TUBB3, VIM

Compounds for genes affiliated with Ovarian Carcinosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5F8
2dexamethasone44 49 28 1112.7VEGFA, F8
3eosin449.6VIM, MUC1
4dmso449.6PGR, TUBB3, MUC1
5azd 2171449.6FLT4, VEGFA
6anastrozole44 1110.3MKI67, PGR, ERBB2
7hematoxylin449.3VIM, MUC1, MKI67
8fulvestrant44 49 28 1112.3PGR, MKI67, ERBB2
9letrozole44 49 59 1112.2MKI67, PGR, ERBB2
104-hydroxytamoxifen449.1PGR, VIM, ERBB2
11sunitinib44 49 1111.1VEGFA, FLT4, ERBB2
12zd6474449.0VEGFA, FLT4
13capecitabine44 49 1111.0ERBB2, VEGFA, PGR
14polyethylene glycol449.0MUC1, ERBB2, F8
15taxane448.9PGR, ERBB2, VEGFA
16adriamycin448.9MUC1, PGR, VIM, ERBB2
17leucovorin44 49 1110.9ERBB2, VEGFA, PGR
18biotin44 11 2410.8ERBB2, VIM, MKI67, MUC1
19cyclophosphamide44 49 1110.8ERBB2, MKI67, F8, PGR
20formaldehyde44 249.8MUC1, VIM, MKI67, ERBB2
21agar448.8ERBB2, PGR, VIM, MUC1
22mifepristone44 59 28 1111.7VEGFA, MKI67, MUC1, PGR
23celecoxib44 59 28 49 11 2413.7MKI67, VEGFA, ERBB2
24matrigel448.7VEGFA, MUC1, VIM, FLT4
25gnrh448.6ERBB2, PGR, VIM, MKI67
26docetaxel44 49 59 1111.6ERBB2, PGR, VEGFA, TUBB3
27vinorelbine44 119.6TUBB3, ERBB2, VEGFA, MKI67
28gefitinib44 49 1110.6ERBB2, VIM, VEGFA
29trastuzumab44 49 1110.6MUC1, PGR, VEGFA, ERBB2
30irinotecan44 49 1110.6ERBB2, MKI67, VEGFA, TUBB3
31estradiol44 11 2410.6PGR, VIM, F8, MKI67, MUC1
32geldanamycin44 49 59 1111.6VEGFA, PGR, ERBB2
33aspartate448.5VIM, PGR, ERBB2, TACSTD2, F8
34folate448.4PGR, VIM, MUC1, MKI67, ERBB2
35methotrexate44 49 1110.4VIM, PGR, ERBB2, MUC1, MKI67
36paclitaxel44 49 1110.4FLT4, VEGFA, TUBB3, PGR, ERBB2
37rapamycin448.3VEGFA, VIM, FLT4, ERBB2
38retinoic acid44 249.3MKI67, MUC1, VIM, TUBB3, FLT4, PGR
39testosterone44 59 11 2411.2ERBB2, PGR, MUC1, MKI67, VIM
40alanine448.2TACSTD2, PGR, VIM, F8, ERBB2
41cisplatin44 49 59 1111.2MKI67, ERBB2, MUC1, VEGFA, TUBB3
425fluorouracil448.1MUC1, PGR, ERBB2, MKI67, VEGFA
43thymidylate448.1ERBB2, VIM, TUBB3, MKI67, VEGFA
44progesterone44 59 28 11 2412.0ERBB2, PGR, MUC1, MKI67, F8, VIM
45doxorubicin44 49 119.9VIM, VEGFA, MKI67, PGR, ERBB2
46progestin447.7PGR, F8, VEGFA, MUC1, ERBB2, VIM
47tamoxifen44 49 28 1110.6ERBB2, VIM, VEGFA, MKI67, PGR, MUC1
48tyrosine447.4TUBB3, F8, FLT4, VEGFA, MKI67, MUC1
49paraffin447.3ERBB2, PGR, MUC1, MKI67, VEGFA, FLT4
50vegf446.8F8, ERBB2, PGR, MUC1, MKI67, VEGFA

GO Terms for genes affiliated with Ovarian Carcinosarcoma

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16Gene Ontology
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Biological processes related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.7PGR, TACSTD2
2positive regulation of protein kinase C signaling cascadeGO:0900379.4FLT4, VEGFA
3positive regulation of endothelial cell migrationGO:0105959.3VEGFA, FLT4
4cellular response to vascular endothelial growth factor stimulusGO:0359249.2VEGFA, FLT4
5vascular endothelial growth factor receptor signaling pathwayGO:0480109.0VEGFA, FLT4
6positive regulation of protein phosphorylationGO:0019348.8ERBB2, VEGFA, FLT4

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.4ERBB2, FLT4
2transmembrane receptor protein tyrosine kinase activityGO:0047149.2FLT4, ERBB2
3protein C-terminus bindingGO:0080228.8ERBB2, MKI67, VIM
4protein bindingGO:0055156.4F8, FLT4, VEGFA, MKI67, MUC1, PGR

Products for genes affiliated with Ovarian Carcinosarcoma

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Sources for Ovarian Carcinosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet