MCID: OVR044
MIFTS: 48

Ovarian Carcinosarcoma malady

Rare diseases, Cancer diseases categories

Summaries for Ovarian Carcinosarcoma

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards: Ovarian Carcinosarcoma, also known as malignant mixed mullerian tumor of the ovary, is related to malignant mixed mullerian tumor and breast cancer. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Cytoskeleton remodeling Keratin filaments. The compounds azd 2171 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and small intestine, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Ovarian Carcinosarcoma

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9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian carcinosarcoma 9 44 63
malignant mixed mullerian tumor of the ovary 44
ovarian malignant mesodermal mixed tumor 9
ovarian malignant mixed mullerian tumor 9
malignant mixed mesodermal tumor 63
ovarian mmmt 9


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Disease Ontology9 DOID:6170
NCIt41 C9192

Related Diseases for Ovarian Carcinosarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mixed mullerian tumor31.0VIM, PGR
2breast cancer30.4TUBB3, MKI67, VEGFA, ERBB2, PGR, FLT4
3cystadenocarcinoma30.3MUC1
4angiosarcoma30.2VIM, FLT4, MUC1
5melanoma30.0VIM, MKI67, VEGFA, FLT4
6bilateral breast cancer10.5
7pancreatitis10.4
8malignant mixed epithelial mesenchymal tumor of the ovary10.3
9hidradenoma10.1MUC1
10hydrocele10.1FLT4
11lymphangiosarcoma10.1F8
12syringoma10.1MUC1
13serous cystadenocarcinoma10.1
14thromboembolism10.1
15kidney cancer10.1VEGFA
16breast fibroadenoma10.1PGR
17adenosarcoma10.1PGR
18central retinal vein occlusion10.1VEGFA
19adenomatoid tumor10.1VIM
20glomus tumor10.1VIM
21lymphangioma10.1F8, FLT4
22vascular cancer10.1FLT4, VEGFA
23sertoli-leydig cell tumor10.1MUC1, PGR
24primary hyperoxaluria10.1F8, VEGFA
25secretory meningioma10.1MUC1, VIM
26clear cell ependymoma10.1MUC1, VIM
27meningioma10.1MKI67, PGR
28hemangioblastoma10.1VEGFA, MUC1
29mesenchymal chondrosarcoma10.1MUC1, VIM
30epithelioid sarcoma10.0MUC1, VIM
31mucoepidermoid carcinoma10.0MUC1, MKI67
32dermatofibrosarcoma protuberans10.0VIM, MUC1
33perineurioma10.0VIM, MUC1
34rhabdoid tumor10.0VIM, MUC1
35adenosquamous carcinoma10.0MUC1, PGR
36benign meningioma10.0MKI67, PGR
37laryngeal benign neoplasm10.0FLT4, MKI67
38chordoma10.0VIM, MUC1
39malignant peripheral nerve sheath tumor10.0MUC1, VIM
40giant cell tumor10.0MUC1, VIM
41abrikosov's tumor10.0VIM, MUC1
42endometrial stromal sarcoma10.0VIM, PGR
43cutaneous paget's disease10.0ERBB2, MUC1
44hemangioma10.0FLT4, VEGFA, F8
45angiomyolipoma10.0VIM, PGR
46neurofibroma10.0VIM, MUC1
47fibromatosis10.0VIM, PGR
48oxyphilic adenoma10.0MUC1, VIM
49spindle cell sarcoma10.0VIM, FLT4, MUC1
50laryngeal squamous cell carcinoma10.0MKI67, VEGFA, FLT4

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Symptoms for Ovarian Carcinosarcoma

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Drugs & Therapeutics for Ovarian Carcinosarcoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Ovarian Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Ovarian Carcinosarcoma

Search NIH Clinical Center for Ovarian Carcinosarcoma

Search CenterWatch for Ovarian Carcinosarcoma

Genetic Tests for Ovarian Carcinosarcoma

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Anatomical Context for Ovarian Carcinosarcoma

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34MalaCards
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MalaCards organs/tissues related to Ovarian Carcinosarcoma:

34
Ovary, Small intestine

Animal Models for Ovarian Carcinosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0VEGFA, PGR, MUC1, ERBB2, TACSTD2
2MP:00107717.8VEGFA, PGR, FLT4, MUC1, ERBB2, TACSTD2
3MP:00053697.6VEGFA, PGR, FLT4, VIM, ERBB2
4MP:00053857.6ERBB2, VIM, FLT4, PGR, VEGFA
5MP:00028737.6VEGFA, PGR, FLT4, MUC1, ERBB2
6MP:00053807.5VEGFA, PGR, FLT4, VIM, ERBB2, TACSTD2
7MP:00053897.3VEGFA, PGR, FLT4, VIM, F8, ERBB2
8MP:00053847.3TUBB3, VEGFA, PGR, VIM, ERBB2, TACSTD2
9MP:00107686.8TUBB3, VEGFA, PGR, FLT4, VIM, F8
10MP:00053766.8TACSTD2, VEGFA, PGR, FLT4, VIM, MUC1

Publications for Ovarian Carcinosarcoma

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53PubMed
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Articles related to Ovarian Carcinosarcoma:

(show all 26)
idTitleAuthorsYear
1
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
2
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
3
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
4
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
5
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
6
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
7
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
8
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
9
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
10
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
11
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
12
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
13
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
14
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
15
Current management of ovarian carcinosarcoma. (17362309)
2007
16
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
17
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
18
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
19
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
20
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
21
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
22
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
23
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
24
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
25
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
26
MR images of ovarian carcinosarcoma. (10646984)
1999

Variations for Ovarian Carcinosarcoma

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Expression for genes affiliated with Ovarian Carcinosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Carcinosarcoma

Search GEO for disease gene expression data for Ovarian Carcinosarcoma.

Pathways for genes affiliated with Ovarian Carcinosarcoma

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51PathCards, 56Reactome, 61Thomson Reuters, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database
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Pathways related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FLT4, VEGFA
29.5VIM, TUBB3
3
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.8ERBB2, FLT4, VEGFA
48.5VEGFA, VIM, ERBB2
5
Show member pathways
8.0ERBB2, MUC1, VIM, FLT4, TUBB3
6
Show member pathways
7.9TUBB3, VEGFA, PGR, FLT4, ERBB2

Compounds for genes affiliated with Ovarian Carcinosarcoma

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1azd 2171469.8FLT4, VEGFA
2hematoxylin469.2MUC1, VIM, MKI67
3sunitinib46 52 1211.1VEGFA, FLT4, ERBB2
4anastrozole46 52 1211.1MKI67, PGR, ERBB2
5fulvestrant46 52 30 1212.0MKI67, PGR, ERBB2
6letrozole46 52 62 1212.0MKI67, PGR, ERBB2
7capecitabine46 52 1211.0ERBB2, PGR, VEGFA
8mifepristone46 30 62 1212.0MKI67, VEGFA, PGR, MUC1
9taxane469.0VEGFA, PGR, ERBB2
10dmso468.9TUBB3, PGR, VIM, MUC1
11matrigel468.9VEGFA, FLT4, VIM, MUC1
12leucovorin46 52 1210.8VEGFA, PGR, ERBB2
13vinorelbine46 52 1210.8TUBB3, MKI67, VEGFA, ERBB2
14irinotecan46 52 1210.8ERBB2, VEGFA, MKI67, TUBB3
15celecoxib46 62 30 52 25 1213.7ERBB2, VEGFA, MKI67
16docetaxel46 52 62 1211.7TUBB3, VEGFA, PGR, ERBB2
17trastuzumab46 52 1210.7VEGFA, PGR, MUC1, ERBB2
18biotin46 25 1210.6MKI67, VIM, MUC1, ERBB2
194-hydroxytamoxifen468.6PGR, VIM, ERBB2
20polyethylene glycol468.6MUC1, F8, ERBB2
21formaldehyde46 259.5MKI67, VIM, MUC1, ERBB2
22adriamycin468.5ERBB2, MUC1, VIM, PGR
23estradiol46 25 1210.5F8, MUC1, VIM, PGR, MKI67
24agar468.4PGR, VIM, MUC1, ERBB2
25gefitinib46 52 1210.4ERBB2, VIM, VEGFA
26gnrh468.3ERBB2, VIM, PGR, MKI67
27cisplatin46 52 62 1211.3TUBB3, MKI67, VEGFA, MUC1, ERBB2
28rapamycin468.3VEGFA, FLT4, VIM, ERBB2
29retinoic acid46 259.2TUBB3, MKI67, PGR, FLT4, VIM, MUC1
305fluorouracil468.2MKI67, VEGFA, PGR, MUC1, ERBB2
31cyclophosphamide46 52 1210.2ERBB2, F8, PGR, VEGFA, MKI67
32thymidylate468.2TUBB3, MKI67, VEGFA, VIM, ERBB2
33aspartate468.1TACSTD2, ERBB2, F8, VIM, PGR
34folate468.1MKI67, PGR, VIM, MUC1, ERBB2
35methotrexate52 46 1210.1MKI67, PGR, VIM, MUC1, ERBB2
36genistein46 30 62 3 25 1213.0ERBB2, VIM, PGR, VEGFA
37testosterone46 62 25 1210.9ERBB2, MUC1, VIM, PGR, MKI67
38doxorubicin46 52 129.9MKI67, VEGFA, PGR, VIM, ERBB2
39alanine467.9TACSTD2, ERBB2, F8, VIM, PGR
40cycloheximide467.8MKI67, VEGFA, PGR, VIM, ERBB2
41progesterone46 30 62 25 1211.7MKI67, PGR, VIM, MUC1, F8, ERBB2
42progestin467.7VEGFA, PGR, VIM, MUC1, F8, ERBB2
43serine467.6TUBB3, MKI67, VIM, MUC1, F8, ERBB2
44tamoxifen46 52 30 1210.6MKI67, VEGFA, PGR, VIM, MUC1, ERBB2
45tyrosine467.6TUBB3, MKI67, VEGFA, FLT4, MUC1, F8
46paclitaxel46 52 129.3TUBB3, MKI67, VEGFA, PGR, FLT4, VIM
47dexamethasone46 52 30 1210.3VEGFA, PGR, FLT4, VIM, MUC1, F8
48paraffin467.3MKI67, VEGFA, PGR, FLT4, VIM, MUC1
49vegf466.8MKI67, VEGFA, PGR, FLT4, VIM, MUC1
50estrogen466.5ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

GO Terms for genes affiliated with Ovarian Carcinosarcoma

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17Gene Ontology
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Cellular components related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5F8, VEGFA
2cytoplasmGO:0057376.7ERBB2, MUC1, VIM, FLT4, VEGFA, MKI67

Biological processes related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.8PGR, TACSTD2
2positive regulation of protein kinase C signalingGO:0900379.8VEGFA, FLT4
3cellular response to vascular endothelial growth factor stimulusGO:0359249.8FLT4, VEGFA
4vascular endothelial growth factor receptor signaling pathwayGO:0480109.7FLT4, VEGFA
5positive regulation of endothelial cell migrationGO:0105959.6VEGFA, FLT4
6positive regulation of cell adhesionGO:0457859.2VEGFA, ERBB2
7positive regulation of epithelial cell proliferationGO:0506799.1ERBB2, VEGFA
8positive regulation of MAP kinase activityGO:0434069.0ERBB2, VEGFA
9positive regulation of protein phosphorylationGO:0019349.0ERBB2, FLT4, VEGFA
10cell proliferationGO:0082838.6TACSTD2, ERBB2, MKI67

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.3ERBB2, FLT4
2growth factor bindingGO:0198389.0ERBB2, FLT4
3protein C-terminus bindingGO:0080228.5MKI67, VIM, ERBB2
4protein bindingGO:0055156.1ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

Products for genes affiliated with Ovarian Carcinosarcoma

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Sources for Ovarian Carcinosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet