MCID: OVR044
MIFTS: 38

Ovarian Carcinosarcoma malady

Summaries for Ovarian Carcinosarcoma

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards: Ovarian Carcinosarcoma, also known as malignant mixed mullerian tumor of the ovary, is related to malignant mixed mullerian tumor and bilateral breast cancer. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Rho Family GTPases. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and integument.

Aliases & Classifications for Ovarian Carcinosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

ovarian carcinosarcoma 8 43 61
malignant mixed mullerian tumor of the ovary 43
ovarian malignant mesodermal mixed tumor 8
ovarian malignant mixed mullerian tumor 8
malignant mixed mesodermal tumor 61
ovarian mmmt 8


External Ids:

Disease Ontology8 DOID:6170
NCIt40 C9192

Related Diseases for Ovarian Carcinosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mixed mullerian tumor30.9PGR, VIM
2bilateral breast cancer30.6PGR
3uterine carcinosarcoma30.6ERBB2
4adenosarcoma30.4PGR
5angiosarcoma30.1VIM, FLT4, MUC1
6vaginal carcinosarcoma10.4
7teratoma10.3
8malignant mixed epithelial mesenchymal tumor of the ovary10.2
9serous cystadenocarcinoma10.1
10ovarian serous cystadenocarcinoma10.1
11ovarian angiosarcoma10.1
12cervical cancer10.0FLT4
13cystadenocarcinoma10.0MUC1
14hemangioendothelioma10.0FLT4
15hepatitis10.0F8
16hidradenoma10.0MUC1
17syringoma10.0MUC1
18hepatitis c10.0F8
19kaposi's sarcoma10.0F8
20lymphangiosarcoma10.0F8
21oligodendroglioma10.0MKI67
22hepatitis b10.0F8
23hydrocele10.0FLT4
24gynecomastia10.0PGR
25kidney cancer10.0VEGFA
26lymphangioleiomyomatosis10.0PGR
27von hippel-lindau disease10.0VEGFA
28thromboembolism10.0F8
29adenomatoid tumor10.0VIM
30wilms tumor10.0VIM
31glomus tumor10.0VIM
32central retinal vein occlusion10.0VEGFA
33rhabdomyosarcoma10.0VIM
34liposarcoma10.0VIM
35laryngeal carcinoma10.0FLT4, MKI67
36blindness10.0VEGFA
37leukemia10.0FLT4, F8
38tuberous sclerosis10.0VIM
39stomach cancer10.0ERBB2
40hemangioblastoma10.0MUC1, VEGFA
41biliary tract cancer10.0ERBB2
42sertoli-leydig cell tumor10.0MUC1, PGR
43medulloblastoma10.0ERBB2
44benign meningioma10.0PGR, MKI67
45leiomyomatosis10.0PGR
46chordoma10.0MUC1, VIM
47secretory meningioma10.0VIM, MUC1
48vascular cancer10.0FLT4, VEGFA
49rheumatoid arthritis10.0VEGFA
50meningioma10.0PGR, MKI67

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Clinical Features for Ovarian Carcinosarcoma

Drugs & Therapeutics for Ovarian Carcinosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Ovarian Carcinosarcoma

Drug clinical trials:

Search ClinicalTrials for Ovarian Carcinosarcoma

Search NIH Clinical Center for Ovarian Carcinosarcoma

Search CenterWatch for Ovarian Carcinosarcoma

Genetic Tests for Ovarian Carcinosarcoma

Anatomical Context for Ovarian Carcinosarcoma

Animal Models for Ovarian Carcinosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4TACSTD2, F8, PGR
2MP:00107719.4VEGFA, TACSTD2
3MP:00053898.3ERBB2, VEGFA, FLT4, F8
4MP:00020067.6VEGFA, MUC1, PGR, TACSTD2, ERBB2
5MP:00053807.4PGR, TACSTD2, ERBB2, FLT4, VIM, VEGFA
6MP:00107686.6ERBB2, VIM, TUBB3, F8, FLT4, VEGFA

Publications for Ovarian Carcinosarcoma

Sources:
51PubMed
See all sources

Articles related to Ovarian Carcinosarcoma:

(show all 31)
idTitleAuthorsYear
1
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
2
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
3
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
4
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
5
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
6
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
7
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
8
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
9
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
10
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
11
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
12
Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report. (21639901)
2011
13
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
14
Prediction of Chemotherapy Response With Platinum and Taxane in the Advanced Stage of Ovarian and Uterine Carcinosarcoma: A Clinical Implication of In vitro Drug Resistance Assay. (19875949)
2010
15
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
16
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
17
Current management of ovarian carcinosarcoma. (17362309)
2007
18
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
19
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
20
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
21
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
22
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
23
Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. (12694655)
2003
24
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
25
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
26
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
27
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
28
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
29
MR images of ovarian carcinosarcoma. (10646984)
1999
30
Utility of immunohistochemistry in distinguishing ovarian sertoli-stromal cell tumors from carcinosarcomas. (1612579)
1992
31
Bilateral ovarian endometriosis associated with carcinosarcoma of the right ovary and endometrioid carcinoma of the left ovary. (707438)
1978

Genetic Variations for Ovarian Carcinosarcoma

Expression for genes affiliated with Ovarian Carcinosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Carcinosarcoma

Search GEO for disease gene expression data for Ovarian Carcinosarcoma.

Pathways for genes affiliated with Ovarian Carcinosarcoma

Sources:
54Reactome, 52QIAGEN
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Pathways related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3VEGFA, FLT4
2
Hide members
8.3ERBB2, MUC1, FLT4, TUBB3, VIM

Compounds for genes affiliated with Ovarian Carcinosarcoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
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Compounds related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5F8
2dexamethasone45 50 29 1112.7VEGFA, F8
3eosin459.6MUC1, VIM
4dmso459.6PGR, MUC1, TUBB3
5azd 2171459.6VEGFA, FLT4
6anastrozole45 1110.3ERBB2, PGR, MKI67
7hematoxylin459.3VIM, MKI67, MUC1
8fulvestrant45 50 29 1112.3ERBB2, PGR, MKI67
9letrozole45 50 60 1112.2MKI67, PGR, ERBB2
104-hydroxytamoxifen459.1ERBB2, PGR, VIM
11sunitinib45 50 1111.1FLT4, VEGFA, ERBB2
12zd6474459.0FLT4, VEGFA
13capecitabine45 50 1111.0VEGFA, PGR, ERBB2
14polyethylene glycol459.0ERBB2, MUC1, F8
15taxane458.9VEGFA, PGR, ERBB2
16adriamycin458.9ERBB2, PGR, MUC1, VIM
17leucovorin45 50 1110.9ERBB2, PGR, VEGFA
18biotin45 11 2410.8VIM, MKI67, MUC1, ERBB2
19cyclophosphamide45 50 1110.8F8, MKI67, PGR, ERBB2
20formaldehyde45 249.8ERBB2, MUC1, MKI67, VIM
21agar458.8VIM, MUC1, PGR, ERBB2
22mifepristone45 60 29 1111.7PGR, MUC1, MKI67, VEGFA
23celecoxib45 60 29 50 11 2413.7VEGFA, MKI67, ERBB2
24matrigel458.7VIM, FLT4, VEGFA, MUC1
25gnrh458.6VIM, MKI67, PGR, ERBB2
26docetaxel45 50 60 1111.6TUBB3, VEGFA, PGR, ERBB2
27vinorelbine45 119.6ERBB2, MKI67, VEGFA, TUBB3
28gefitinib45 50 1110.6VIM, VEGFA, ERBB2
29trastuzumab45 50 1110.6VEGFA, MUC1, PGR, ERBB2
30irinotecan45 50 1110.6TUBB3, VEGFA, MKI67, ERBB2
31estradiol45 11 2410.6VIM, F8, MKI67, MUC1, PGR
32geldanamycin45 50 60 1111.6ERBB2, PGR, VEGFA
33aspartate458.5VIM, F8, PGR, TACSTD2, ERBB2
34folate458.4VIM, MKI67, MUC1, PGR, ERBB2
35methotrexate45 50 1110.4VIM, MKI67, MUC1, PGR, ERBB2
36paclitaxel45 50 1110.4TUBB3, FLT4, VEGFA, PGR, ERBB2
37rapamycin458.3ERBB2, VEGFA, FLT4, VIM
38retinoic acid45 249.3VIM, TUBB3, FLT4, MKI67, MUC1, PGR
39testosterone45 60 11 2411.2ERBB2, PGR, MUC1, MKI67, VIM
40alanine458.2VIM, F8, PGR, TACSTD2, ERBB2
41cisplatin45 50 60 1111.2TUBB3, VEGFA, MKI67, MUC1, ERBB2
425fluorouracil458.1ERBB2, PGR, MUC1, MKI67, VEGFA
43thymidylate458.1VIM, TUBB3, VEGFA, MKI67, ERBB2
44progesterone45 60 29 11 2412.0VIM, F8, MKI67, MUC1, PGR, ERBB2
45doxorubicin45 50 119.9VIM, VEGFA, MKI67, PGR, ERBB2
46progestin457.7ERBB2, PGR, MUC1, VEGFA, F8, VIM
47tamoxifen45 50 29 1110.6VIM, VEGFA, MKI67, MUC1, PGR, ERBB2
48tyrosine457.4TUBB3, F8, FLT4, VEGFA, MKI67, MUC1
49paraffin457.3VIM, FLT4, VEGFA, MKI67, MUC1, PGR
50vegf456.8VIM, F8, FLT4, VEGFA, MKI67, MUC1

GO Terms for genes affiliated with Ovarian Carcinosarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.7PGR, TACSTD2
2positive regulation of protein kinase C signaling cascadeGO:0900379.4FLT4, VEGFA
3positive regulation of endothelial cell migrationGO:0105959.3VEGFA, FLT4
4cellular response to vascular endothelial growth factor stimulusGO:0359249.2VEGFA, FLT4
5vascular endothelial growth factor receptor signaling pathwayGO:0480109.0VEGFA, FLT4
6positive regulation of protein phosphorylationGO:0019348.8ERBB2, VEGFA, FLT4

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.4ERBB2, FLT4
2transmembrane receptor protein tyrosine kinase activityGO:0047149.2FLT4, ERBB2
3protein C-terminus bindingGO:0080228.8ERBB2, MKI67, VIM
4protein bindingGO:0055156.4F8, FLT4, VEGFA, MKI67, MUC1, PGR

Products for genes affiliated with Ovarian Carcinosarcoma

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Sources for Ovarian Carcinosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet