MCID: OVR044
MIFTS: 49

Ovarian Carcinosarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Ovarian Carcinosarcoma

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NIH Rare Diseases:42 Ovarian carcinosarcoma is a cancer of the ovary that is composed of two types of cells, namely carcinoma cells and sarcoma cells.  ovarian carcinosarcoma is also known as a malignant mixed mullerian tumor of the ovary.  the average age of women at the time of diagnosis is 60 to 70 years.  symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating or other digestive issues.  the cause of ovarian carcinosarcoma is currently unknown.  treatment usually consists of surgery (sometimes called debulking) and chemotherapy. last updated: 9/4/2012

MalaCards based summary: Ovarian Carcinosarcoma, also known as ovarian malignant mixed mullerian tumor, is related to malignant mixed mullerian tumor and cystadenocarcinoma. An important gene associated with Ovarian Carcinosarcoma is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways are Signaling by VEGF and Cytoskeleton remodeling Keratin filaments. The compounds azd 2171 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include ovary and small intestine, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Ovarian Carcinosarcoma

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Ovarian Carcinosarcoma, Aliases & Descriptions:

Name: Ovarian Carcinosarcoma 8 42 62
Ovarian Malignant Mixed Mullerian Tumor 8 62
Malignant Mixed Mullerian Tumor of the Ovary 42
 
Ovarian Malignant Mesodermal Mixed Tumor 8
Malignant Mixed Mesodermal Tumor 62
Ovarian Mmmt 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:6170
NCIt39 C9192

Related Diseases for Ovarian Carcinosarcoma

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Diseases related to Ovarian Carcinosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mixed mullerian tumor31.1VIM, PGR
2cystadenocarcinoma31.0MUC1
3angiosarcoma30.3FLT4, VIM, MUC1
4melanoma29.7MKI67, VEGFA, FLT4, VIM
5breast cancer29.5TUBB3, MKI67, VEGFA, PGR, FLT4, MUC1
6hidradenoma10.5MUC1
7hydrocele10.5FLT4
8syringoma10.5MUC1
9lymphangiosarcoma10.5F8
10bilateral breast cancer10.5
11kidney cancer10.4VEGFA
12breast fibroadenoma10.4PGR
13adenosarcoma10.4PGR
14central retinal vein occlusion10.4VEGFA
15adenomatoid tumor10.4VIM
16pancreatitis10.4
17paraganglioma10.4VIM
18lymphangioma10.3FLT4, F8
19vascular cancer10.3VEGFA, FLT4
20sertoli-leydig cell tumor10.3PGR, MUC1
21malignant mixed epithelial mesenchymal tumor of the ovary10.3
22primary hyperoxaluria10.3VEGFA, F8
23secretory meningioma10.3MUC1, VIM
24clear cell ependymoma10.2MUC1, VIM
25meningioma10.2MKI67, PGR
26hemangioblastoma10.2MUC1, VEGFA
27mesenchymal chondrosarcoma10.2VIM, MUC1
28epithelioid sarcoma10.2VIM, MUC1
29mucoepidermoid carcinoma10.2MKI67, MUC1
30dermatofibrosarcoma protuberans10.2VIM, MUC1
31adenosquamous carcinoma10.2PGR, MUC1
32rhabdoid tumor10.2VIM, MUC1
33benign meningioma10.2PGR, MKI67
34perineurioma10.2VIM, MUC1
35laryngeal benign neoplasm10.2MKI67, FLT4
36chordoma10.2VIM, MUC1
37malignant peripheral nerve sheath tumor10.2VIM, MUC1
38abrikosov's tumor10.2VIM, MUC1
39giant cell tumor10.2VIM, MUC1
40endometrial stromal sarcoma10.1VIM, PGR
41cutaneous paget's disease10.1ERBB2, MUC1
42angiomyolipoma10.1VIM, PGR
43hemangioma10.1VEGFA, FLT4, F8
44neurofibroma10.1VIM, MUC1
45fibromatosis10.1VIM, PGR
46pleomorphic liposarcoma10.1
47serous cystadenocarcinoma10.1
48liposarcoma10.1
49rhabdomyosarcoma10.1
50thromboembolism10.1

Graphical network of the top 20 diseases related to Ovarian Carcinosarcoma:



Diseases related to ovarian carcinosarcoma

Symptoms for Ovarian Carcinosarcoma

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Drugs & Therapeutics for Ovarian Carcinosarcoma

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Drug clinical trials:

Search ClinicalTrials for Ovarian Carcinosarcoma

Search NIH Clinical Center for Ovarian Carcinosarcoma

Genetic Tests for Ovarian Carcinosarcoma

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Anatomical Context for Ovarian Carcinosarcoma

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MalaCards organs/tissues related to Ovarian Carcinosarcoma:

32
Ovary, Small intestine

Animal Models for Ovarian Carcinosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Carcinosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0VEGFA, PGR, MUC1, ERBB2, TACSTD2
2MP:00107717.8VEGFA, PGR, FLT4, MUC1, ERBB2, TACSTD2
3MP:00053697.6VEGFA, PGR, FLT4, VIM, ERBB2
4MP:00053857.6ERBB2, VIM, FLT4, PGR, VEGFA
5MP:00028737.6VEGFA, PGR, FLT4, MUC1, ERBB2
6MP:00053807.5VEGFA, PGR, FLT4, VIM, ERBB2, TACSTD2
7MP:00053897.3VEGFA, PGR, FLT4, VIM, F8, ERBB2
8MP:00053847.3TUBB3, VEGFA, PGR, VIM, ERBB2, TACSTD2
9MP:00107686.8TUBB3, VEGFA, PGR, FLT4, VIM, F8
10MP:00053766.8TACSTD2, VEGFA, PGR, FLT4, VIM, MUC1

Publications for Ovarian Carcinosarcoma

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Articles related to Ovarian Carcinosarcoma:

(show all 30)
idTitleAuthorsYear
1
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. (24587930)
2014
2
A rare case of ovarian carcinosarcoma with neuroendocrine differentiation. (24971408)
2014
3
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Uterine and Ovarian Carcinosarcoma. (25341582)
2014
4
Radical surgical cytoreduction in the treatment of ovarian carcinosarcoma. (24631447)
2014
5
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (23450567)
2013
6
Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report. (23722511)
2013
7
Prognostic determinants in patients with uterine and ovarian carcinosarcoma. (23947079)
2013
8
Ovarian carcinosarcoma: effects of cytoreductive status and platinum-based chemotherapy on survival. (23781249)
2013
9
Large polyp of the small intestine: an unexpected metastasis of ovarian carcinosarcoma. (23926191)
2013
10
Complete response with pegylated liposomal doxorubicin as a second-line therapy in metastatic ovarian carcinosarcoma: Significance of assessment of the response by FDG-PET. (24371621)
2012
11
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. (22209775)
2012
12
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody. (22075385)
2011
13
Solitary splenic metastasis from ovarian carcinosarcoma: a case report. (21310035)
2011
14
Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. (21293284)
2011
15
A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide. (21417665)
2011
16
Whole-body FDG PET/CT in diagnosis of internal mammary nodal metastasis of ovarian carcinosarcoma. (21552025)
2011
17
Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. (19820383)
2009
18
Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. (18321361)
2008
19
Current management of ovarian carcinosarcoma. (17362309)
2007
20
A case of primary ovarian carcinosarcoma and vulvar carcinoma with widespread lymphadenopathy. (16846899)
2006
21
Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma. Report of two cases. (16645301)
2006
22
Clinical features and outcomes of uterine and ovarian carcinosarcoma. (16271748)
2006
23
Clinicopathological features of ovarian carcinosarcomas: a single institution experience. (15589592)
2005
24
Primary ovarian carcinosarcoma: a case report and review of the literature. (15493190)
2004
25
Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. (12893202)
2003
26
Unusual Trousseau's syndrome in ovarian carcinosarcoma: multiple systemic thromboembolic events. (12554280)
2002
27
Ovarian carcinosarcoma [correction of carcinoma]. (11418412)
2001
28
Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma. (12574850)
2001
29
Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. (11119124)
2000
30
MR images of ovarian carcinosarcoma. (10646984)
1999

Variations for Ovarian Carcinosarcoma

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Expression for genes affiliated with Ovarian Carcinosarcoma

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Expression patterns in normal tissues for genes affiliated with Ovarian Carcinosarcoma

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Pathways for genes affiliated with Ovarian Carcinosarcoma

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Pathways related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FLT4, VEGFA
29.5VIM, TUBB3
3
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.8ERBB2, FLT4, VEGFA
48.5VEGFA, VIM, ERBB2
5
Show member pathways
8.0ERBB2, MUC1, VIM, FLT4, TUBB3
6
Show member pathways
7.9TUBB3, VEGFA, PGR, FLT4, ERBB2

Compounds for genes affiliated with Ovarian Carcinosarcoma

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Compounds related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1azd 2171449.8FLT4, VEGFA
2hematoxylin449.2MKI67, VIM, MUC1
3sunitinib44 50 1111.1ERBB2, VEGFA, FLT4
4anastrozole44 50 1111.1ERBB2, PGR, MKI67
5fulvestrant44 50 28 1112.0PGR, MKI67, ERBB2
6letrozole44 50 61 1112.0ERBB2, MKI67, PGR
7capecitabine44 50 1111.0VEGFA, ERBB2, PGR
8mifepristone44 28 61 1112.0MKI67, MUC1, PGR, VEGFA
9taxane449.0ERBB2, PGR, VEGFA
10dmso448.9PGR, MUC1, VIM, TUBB3
11matrigel448.9VIM, MUC1, FLT4, VEGFA
12leucovorin44 50 1110.8ERBB2, PGR, VEGFA
13vinorelbine44 50 1110.8ERBB2, TUBB3, VEGFA, MKI67
14irinotecan44 50 1110.8ERBB2, TUBB3, VEGFA, MKI67
15celecoxib44 61 28 50 24 1113.7MKI67, VEGFA, ERBB2
16docetaxel44 50 61 1111.7ERBB2, PGR, VEGFA, TUBB3
17trastuzumab44 50 1110.7VEGFA, PGR, ERBB2, MUC1
18biotin44 24 1110.6VIM, MKI67, MUC1, ERBB2
194-hydroxytamoxifen448.6VIM, PGR, ERBB2
20polyethylene glycol448.6F8, MUC1, ERBB2
21formaldehyde44 249.5VIM, MKI67, ERBB2, MUC1
22adriamycin448.5MUC1, ERBB2, VIM, PGR
23estradiol44 24 1110.5MUC1, F8, MKI67, VIM, PGR
24agar448.4PGR, VIM, MUC1, ERBB2
25gefitinib44 50 1110.4VEGFA, ERBB2, VIM
26gnrh448.3ERBB2, MKI67, PGR, VIM
27cisplatin44 50 61 1111.3TUBB3, MUC1, ERBB2, VEGFA, MKI67
28rapamycin448.3FLT4, VIM, VEGFA, ERBB2
29retinoic acid44 249.2MUC1, VIM, TUBB3, MKI67, PGR, FLT4
305fluorouracil448.2ERBB2, MUC1, PGR, VEGFA, MKI67
31cyclophosphamide44 50 1110.2F8, PGR, ERBB2, MKI67, VEGFA
32thymidylate448.2TUBB3, MKI67, VIM, ERBB2, VEGFA
33aspartate448.1F8, PGR, TACSTD2, VIM, ERBB2
34folate448.1VIM, ERBB2, MUC1, PGR, MKI67
35methotrexate50 44 1110.1ERBB2, MKI67, PGR, VIM, MUC1
36genistein44 28 61 2 24 1113.0ERBB2, VIM, PGR, VEGFA
37testosterone44 61 24 1110.9ERBB2, MKI67, PGR, VIM, MUC1
38doxorubicin44 50 119.9MKI67, VEGFA, PGR, VIM, ERBB2
39alanine447.9PGR, VIM, ERBB2, F8, TACSTD2
40cycloheximide447.8MKI67, PGR, VEGFA, VIM, ERBB2
41progesterone44 28 61 24 1111.7MUC1, F8, VIM, ERBB2, PGR, MKI67
42progestin447.7VIM, VEGFA, PGR, MUC1, ERBB2, F8
43serine447.6ERBB2, F8, MUC1, VIM, MKI67, TUBB3
44tamoxifen44 50 28 1110.6PGR, ERBB2, MUC1, VIM, VEGFA, MKI67
45tyrosine447.6MKI67, ERBB2, TUBB3, F8, MUC1, FLT4
46paclitaxel44 50 119.3PGR, VIM, FLT4, TUBB3, MKI67, ERBB2
47dexamethasone44 50 28 1110.3FLT4, PGR, VIM, F8, MUC1, VEGFA
48paraffin447.3ERBB2, MUC1, VIM, FLT4, PGR, VEGFA
49vegf446.8FLT4, PGR, VEGFA, MKI67, VIM, MUC1
50estrogen446.5VIM, F8, ERBB2, PGR, VEGFA, MKI67

GO Terms for genes affiliated with Ovarian Carcinosarcoma

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Cellular components related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5F8, VEGFA
2cytoplasmGO:0057376.7ERBB2, MUC1, VIM, FLT4, VEGFA, MKI67

Biological processes related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.8PGR, TACSTD2
2positive regulation of protein kinase C signalingGO:0900379.8VEGFA, FLT4
3cellular response to vascular endothelial growth factor stimulusGO:0359249.8FLT4, VEGFA
4vascular endothelial growth factor receptor signaling pathwayGO:0480109.7FLT4, VEGFA
5positive regulation of endothelial cell migrationGO:0105959.6VEGFA, FLT4
6positive regulation of cell adhesionGO:0457859.2VEGFA, ERBB2
7positive regulation of epithelial cell proliferationGO:0506799.1ERBB2, VEGFA
8positive regulation of MAP kinase activityGO:0434069.0ERBB2, VEGFA
9positive regulation of protein phosphorylationGO:0019349.0ERBB2, FLT4, VEGFA
10cell proliferationGO:0082838.6TACSTD2, ERBB2, MKI67

Molecular functions related to Ovarian Carcinosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.3ERBB2, FLT4
2growth factor bindingGO:0198389.0ERBB2, FLT4
3protein C-terminus bindingGO:0080228.5MKI67, VIM, ERBB2
4protein bindingGO:0055156.1ERBB2, TUBB3, MKI67, VEGFA, PGR, FLT4

Products for genes affiliated with Ovarian Carcinosarcoma

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