MCID: OVR034
MIFTS: 35

Ovarian Clear Cell Adenocarcinoma malady

Cancer diseases category

Summaries for Ovarian Clear Cell Adenocarcinoma

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34MalaCards
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MalaCards: Ovarian Clear Cell Adenocarcinoma is related to adenocarcinoma and endometriosis. An important gene associated with Ovarian Clear Cell Adenocarcinoma is HOXA10 (homeobox A10), and among its related pathways is Selected targets of HNF1. The compounds diethylstilbestrol and isoflavone have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Ovarian Clear Cell Adenocarcinoma

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9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian clear cell adenocarcinoma 9 11 63


External Ids:

Disease Ontology9 DOID:5304
NCIt41 C40078

Related Diseases for Ovarian Clear Cell Adenocarcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Ovarian Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.5IGFBP1, PTHLH, ESR2, STMN1, STS, HNF1B
2endometriosis30.6HNF1B, STS, ESR2, IGFBP1, HOXA10
3clear cell adenocarcinoma11.2
4hypoxia10.5
5hypercalcemia10.4
6mucinous adenocarcinoma10.3
7renal cell carcinoma10.3
8clear cell adenocarcinoma of ovary10.3
9osteoporosis, postmenopausal10.0ESR2, PTHLH
10prolactinoma10.0ESR2, PTHLH
11primary hyperparathyroidism10.0PTHLH, IGFBP1
12pancreatic cancer10.0ESR2, PTHLH
13glucose intolerance10.0HNF1B, IGFBP1
14hematologic cancer10.0STMN1, PTHLH
15cryptorchidism10.0STS, HOXA10
16osteoporosis10.0ESR2, PTHLH
17polycystic ovary syndrome10.0ESR2, IGFBP1
18hyperinsulinism10.0IGFBP1, HNF1B
19leiomyoma10.0ESR2, STS
20chronic kidney failure10.0HNF1B, PTHLH, IGFBP1
21infertility10.0ESR2, IGFBP1, HOXA10
22hypertrophy of breast10.0IGFBP1, PTHLH, HNF1B
23acute lymphocytic leukemia10.0IGFBP1, PTHLH, STMN1
24short stature10.0STS, IGFBP1
25insulin resistance10.0IGFBP1, ESR2, HNF1B
26diabetes mellitus10.0HNF1B, ESR2, IGFBP1
27uterine fibroid9.9IGFBP1, ESR2, STS
28endometrial carcinoma9.9STS, ESR2, IGFBP1
29breast cancer9.9STS, ESR2
30tongue squamous cell carcinoma9.9STMN1, PTHLH, IGFBP1
31osteosarcoma9.9IGFBP1, PTHLH, ESR2, STMN1
32lung cancer9.9STMN1, ESR2, PTHLH, IGFBP1
33leukemia9.9STMN1, ESR2, IGFBP1, HOXA10
34ovarian cancer9.9ESR2, STMN1, STS, HNF1B
35prostate cancer9.8IGFBP1, PTHLH, ESR2, STMN1, STS, HNF1B

Graphical network of the top 20 diseases related to Ovarian Clear Cell Adenocarcinoma:



Diseases related to ovarian clear cell adenocarcinoma

Symptoms for Ovarian Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Ovarian Clear Cell Adenocarcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ovarian Clear Cell Adenocarcinoma

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Anatomical Context for Ovarian Clear Cell Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Ovarian Clear Cell Adenocarcinoma:

34
Ovary

Animal Models for Ovarian Clear Cell Adenocarcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Clear Cell Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2ESR2, PTHLH, HOXA10
2MP:00053798.4HNF1B, ESR2, PTHLH, HOXA10

Publications for Ovarian Clear Cell Adenocarcinoma

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53PubMed
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Articles related to Ovarian Clear Cell Adenocarcinoma:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. (23726144)
2013
2
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. (24244679)
2013
3
Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene. (23430509)
2013
4
Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma. (23805888)
2013
5
Stathmin Regulates Hypoxia-Inducible Factor-1I+ Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma. (23819061)
2013
6
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. (23469222)
2013
7
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. (22348389)
2012
8
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1I+, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. (22498943)
2012
9
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. (22120431)
2012
10
Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture. (22317866)
2012
11
Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. (22871047)
2012
12
Two cases of ovarian clear cell adenocarcinoma producing estradiol. (22360511)
2012
13
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
14
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
15
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
16
Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma. (22335020)
2011
17
Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group. (21293288)
2011
18
Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma. (21804390)
2011
19
PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (21735444)
2011
20
Analysis of mTOR inhibition-involved pathway in ovarian clear cell adenocarcinoma. (21614172)
2011
21
Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (20546339)
2010
22
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
23
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. (19121088)
2009
24
Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma. (19228748)
2009
25
A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: potential new therapy for ovarian clear cell adenocarcinoma. (18048092)
2008
26
Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. (19020706)
2008
27
Obstructive uropathy as a major presentation of ovarian clear cell adenocarcinoma. (18400599)
2008
28
Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics. (17592265)
2007
29
Specific expression of hepatocyte nuclear factor-1beta in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis. (17270029)
2007
30
Irinotecan hydrochloride (CPT-11) and cisplatin as first-line chemotherapy after initial surgery for ovarian clear cell adenocarcinoma. (18050828)
2007
31
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report. (17624099)
2007
32
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
33
Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis. (16442693)
2006
34
The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells. (16820918)
2006
35
Proteomic search for potential diagnostic markers and therapeutic targets for ovarian clear cell adenocarcinoma. (17022098)
2006
36
Establishment and characterization of the RMG-V cell line from human ovarian clear cell adenocarcinoma. (17022146)
2005
37
Antiproliferative effects of interferon-alphaCon1 on ovarian clear cell adenocarcinoma in vitro and in vivo. (15534119)
2004
38
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
39
Complete response to radiation therapy in a patient with chemotherapy-resistant ovarian clear cell adenocarcinoma. (12439556)
2002
40
Absence of estrogen receptor-alpha expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. (11342781)
2001
41
Hypercalcemia due to parathyroid hormone-related protein produced by primary ovarian clear cell adenocarcinoma: case report. (10637074)
2000
42
A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. (10563197)
1999
43
Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (10206285)
1999
44
Survival probability in ovarian clear cell adenocarcinoma. (10385560)
1999
45
Appearance of primary endometrial and ovarian clear cell adenocarcinoma 17 months postpartum. A case report. (9622703)
1998
46
Establishment and characterization of two human ovarian clear cell adenocarcinoma lines from metastatic lesions with different properties. (7535723)
1995
47
Histologic correlates of progression-free interval and survival in ovarian clear cell adenocarcinoma. (8406197)
1993
48
Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. (1582751)
1992
49
Ovarian clear cell adenocarcinoma. (2920955)
1989
50
Establishment of HUOCA-II, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity. (2435943)
1987

Variations for Ovarian Clear Cell Adenocarcinoma

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Expression for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Ovarian Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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51PathCards, 13EMD Millipore
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Pathways related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HNF1B, IGFBP1

Compounds for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1diethylstilbestrol46 30 1211.9ESR2, HOXA10
2isoflavone469.7ESR2, IGFBP1
3anastrozole46 52 1211.7ESR2, IGFBP1
4clomiphene citrate469.7IGFBP1, ESR2
5octreotide46 62 30 1212.7PTHLH, IGFBP1
6nocodazole46 1210.7STMN1, PTHLH
7rsai469.7IGFBP1, ESR2
8levonorgestrel46 62 30 1212.7ESR2, IGFBP1
9dbc-amp469.7IGFBP1, PTHLH
10androstenedione46 2510.6ESR2, IGFBP1
11letrozole46 52 62 1212.5ESR2, STS
12steroidal469.5STS, ESR2
13phenol46 2510.5STS, ESR2
14mifepristone46 30 62 1212.5ESR2, IGFBP1
153beta-hydroxysteroid469.5ESR2, STS
1617beta-hydroxysteroid469.5STS, ESR2
17prednisolone46 30 1211.4PTHLH, IGFBP1
18rosiglitazone30 46 52 25 1213.4PTHLH, IGFBP1
192-methoxyestradiol46 62 2511.4STS, ESR2
204-hydroxytamoxifen469.4STS, ESR2
21lead469.4STS, PTHLH
22dehydroepiandrosterone sulfate469.4STS, IGFBP1
23hydrocortisone46 3 62 1212.3PTHLH, IGFBP1
24ribonucleic acid469.3ESR2, PTHLH, IGFBP1
25vitamin d469.3IGFBP1, PTHLH, ESR2
26actinomycin d469.3IGFBP1, PTHLH, ESR2
27forskolin46 52 1211.3STMN1, PTHLH, IGFBP1
28thymidine46 2510.2IGFBP1, PTHLH, STMN1
29creatinine469.2STMN1, PTHLH, IGFBP1
30dexamethasone46 52 30 1212.0IGFBP1, PTHLH, ESR2
31cycloheximide469.0HOXA10, IGFBP1, PTHLH, ESR2
32progestins468.9IGFBP1, ESR2, STS
33dhea468.9STS, ESR2, IGFBP1
34estrone46 30 25 1211.9STS, ESR2, IGFBP1
35arginine468.9IGFBP1, PTHLH, ESR2, HNF1B
36cholesterol46 30 25 1211.8IGFBP1, STS, HNF1B
37oligonucleotide468.7HOXA10, STMN1, STS, HNF1B
38vegf468.6IGFBP1, PTHLH, ESR2
39tyrosine468.6STS, STMN1, PTHLH, HOXA10
40progestin468.5IGFBP1, PTHLH, ESR2, STS
41dihydrotestosterone46 30 25 1211.5IGFBP1, PTHLH, ESR2, STS
42tamoxifen46 52 30 1211.5STS, ESR2, PTHLH, IGFBP1
43oxygen46 259.5IGFBP1, PTHLH, STMN1, STS
44estradiol46 25 1210.2HOXA10, IGFBP1, PTHLH, ESR2, STS
45testosterone46 62 25 1211.2STS, ESR2, PTHLH, IGFBP1, HOXA10
46steroid468.2HOXA10, IGFBP1, PTHLH, ESR2, STS
47serine468.0STS, STMN1, ESR2, PTHLH, IGFBP1
48progesterone46 30 62 25 1211.7STS, STMN1, ESR2, PTHLH, IGFBP1, HOXA10
49estrogen467.7HOXA10, IGFBP1, PTHLH, ESR2, STMN1, STS
50retinoic acid46 258.6IGFBP1, PTHLH, ESR2, STMN1, STS, HNF1B

GO Terms for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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17Gene Ontology
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Biological processes related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.7PTHLH, HOXA10
2anterior/posterior pattern specificationGO:0099529.3HNF1B, HOXA10
3epidermis developmentGO:0085449.2STS, PTHLH
4female pregnancyGO:0075659.1STS, PTHLH

Products for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Sources for Ovarian Clear Cell Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet