MCID: OVR034
MIFTS: 43

Ovarian Clear Cell Adenocarcinoma malady

Summaries for Ovarian Clear Cell Adenocarcinoma

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33MalaCards
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MalaCards: Ovarian Clear Cell Adenocarcinoma is related to clear cell adenocarcinoma and adenocarcinoma. An important gene associated with Ovarian Clear Cell Adenocarcinoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Remodeling of Adherens Junctions and Immune response IL-2 activation and signaling pathway. The compounds glutamate and crcs have been mentioned in the context of this disorder. Affiliated tissues include ovary and endothelial, and related mouse phenotypes are nervous system and integument.

Aliases & Classifications for Ovarian Clear Cell Adenocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

ovarian clear cell adenocarcinoma 8 61


External Ids:

Disease Ontology8 DOID:5304
NCIt40 C40078

Related Diseases for Ovarian Clear Cell Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ovarian Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell adenocarcinoma31.7SMAD4, SMAD2, SMAD3, PTHLH
2adenocarcinoma31.7STMN1, MET, AFP, ANXA4, AHR, INHBA
3ovarian endometriosis10.6
4hypoxia10.5
5hypercalcemia10.4
6renal clear cell carcinoma10.3
7ovarian mucinous adenocarcinoma10.3
8clear cell adenofibroma10.3
9endometrial clear cell adenocarcinoma10.3
10mucinous adenocarcinoma10.3
11adenofibroma10.3
12clear cell renal cell carcinoma10.3
13pancreatitis10.0SMAD4
14leiomyosarcoma10.0WT1
15myeloid leukemia10.0WT1
16hepatitis10.0AFP
17pituitary adenoma10.0ESR2
18goiter10.0INHBA
19infertility10.0ESR2
20nephrosis10.0ACTN4
21myeloma10.0PTHLH, MET
22thyroid cancer10.0PIK3CA, MET
23medulloblastoma10.0STMN1, PIK3CA
24prolactinoma10.0PTHLH, ESR2
25cryptorchidism10.0STS, WT1
26leydig cell tumor10.0PTHLH
27osteoarthritis10.0ESR2, PTHLH
28down syndrome10.0AFP, STS
29wilms tumor10.0WT1, ACTN4
30rhabdoid tumor10.0WT1
31diabetes mellitus10.0HNF1B, ESR2, GPX3
32sarcoma10.0STMN1, WT1, MET
33frasier syndrome10.0WT1
34papillary thyroid carcinoma10.0HNF1B, PIK3CA, MET
35pancreatic endocrine carcinoma10.0PTHLH, AFP
36thyroid cancer, anaplastic10.0PTHLH, MET, PIK3CA
37primary hyperoxaluria10.0SMAD2, WT1
38cervical cancer10.0PIK3CA, SMAD4, SMAD2
39hemihypertrophy10.0WT1
40malignant mesothelioma10.0MET, WT1
41cholestasis10.0SMAD2, HNF1B
42chondrosarcoma10.0PTHLH, MET
43hepatoblastoma10.0MET, AFP, AHR
44dysgerminoma10.0PTHLH, AFP, WT1
45endometriosis10.0HNF1B, STS, AHR, ESR2
46familial adenomatous polyposis10.0SMAD2, SMAD3, SMAD4
47polycystic ovary syndrome10.0ESR2
48kidney rhabdoid cancer10.0MET, PIK3CA, WT1
49astrocytoma10.0MET, PIK3CA, TUBB3
50nephrotic syndrome10.0WT1, ACTN4

Graphical network of the top 20 diseases related to Ovarian Clear Cell Adenocarcinoma:



Diseases related to ovarian clear cell adenocarcinoma

Clinical Features for Ovarian Clear Cell Adenocarcinoma

Drugs & Therapeutics for Ovarian Clear Cell Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Ovarian Clear Cell Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Ovarian Clear Cell Adenocarcinoma

Search NIH Clinical Center for Ovarian Clear Cell Adenocarcinoma

Search CenterWatch for Ovarian Clear Cell Adenocarcinoma

Genetic Tests for Ovarian Clear Cell Adenocarcinoma

Anatomical Context for Ovarian Clear Cell Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Ovarian Clear Cell Adenocarcinoma:

33
Ovary, Endothelial

Animal Models for Ovarian Clear Cell Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ovarian Clear Cell Adenocarcinoma:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.2TUBB3, GPX3, ESR2
2MP:001077110.0PIK3CA, AHR, SMAD3, SMAD2, SMAD4
3MP:00053919.9SMAD2, INHBA
4MP:00053899.8WT1, PIK3CA, NEU4, AFP, SMAD3, SMAD2
5MP:00053699.7HNF1B, WT1, STMN1, MET, AHR, INHBA
6MP:00030129.7PIK3CA, MET, AHR, ESR2, SMAD2, WT1
7MP:00020069.7PIK3CA, MET, AFP, AHR, ESR2, SMAD3
8MP:00053709.7HNF1B, WT1, MET, AHR, ESR2, SMAD3
9MP:00053889.6TUBB3, MET, AHR, PTHLH, ESR2, SMAD2
10MP:00053819.6MET, AHR, INHBA, PTHLH, ESR2, SMAD3
11MP:00053799.6HNF1B, WT1, PIK3CA, AFP, AHR, INHBA
12MP:00053809.6HNF1B, WT1, PIK3CA, MET, INHBA, SMAD3
13MP:00053769.4NEU4, STMN1, PIK3CA, HNF1B, AFP, INHBA
14MP:00028739.4WT1, STMN1, MET, MAP4, INHBA, ESR2
15MP:00053879.3HNF1B, WT1, PIK3CA, MET, AHR, ACTN4
16MP:00053849.3TUBB3, WT1, PIK3CA, MET, NEU4, ACTN4
17MP:00053979.3WT1, AHR, INHBA, GPX3, PTHLH, ESR2
18MP:00053859.2WT1, PIK3CA, STMN1, MET, AHR, GPX3
19MP:00053869.2PIK3CA, MET, NEU4, AFP, ANXA4, INHBA
20MP:00053679.2SMAD4, HNF1B, WT1, MET, ANXA4, AHR
21MP:00053788.9AHR, NEU4, MET, PIK3CA, WT1, HNF1B
22MP:00107688.7AFP, NEU4, MET, PIK3CA, WT1, TUBB3

Publications for Ovarian Clear Cell Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Ovarian Clear Cell Adenocarcinoma:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. (23726144)
2013
2
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis. (23762304)
2013
3
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. (24244679)
2013
4
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. (23469222)
2013
5
A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. (24306200)
2013
6
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1I+, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. (22498943)
2012
7
Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma. (23056149)
2012
8
Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. (22871047)
2012
9
Mixed angiosarcoma, clear cell adenocarcinoma and mature teratoma elements in an ovarian tumor: a case report and literature review. (22827762)
2012
10
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
11
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
12
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
13
Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group. (21293288)
2011
14
Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma. (21804390)
2011
15
CRABP1-reduced expression is associated with poorer prognosis in serous and clear cell ovarian adenocarcinoma. (20571827)
2011
16
Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (20134266)
2010
17
Expression of podoplanin in epithelial ovarian carcinomas and its potential as a marker for clear cell adenocarcinoma. (20736762)
2010
18
Prognostic and predictive values of E-cadherin for patients of ovarian clear cell adenocarcinoma. (21119364)
2010
19
Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma. (20486992)
2010
20
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
21
Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma. (19228748)
2009
22
Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics. (17592265)
2007
23
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report. (17624099)
2007
24
Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs. (16996567)
2007
25
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
26
Paclitaxel-platinum combination chemotherapy for advanced or recurrent ovarian clear cell adenocarcinoma: a multicenter trial. (16445610)
2006
27
Persistent and moderate hypercalcemia related to an ovarian clear cell adenocarcinoma: Pre- and postoperative parathyroid hormone related-peptide and 1,25-dihydroxyvitamin D3 levels. (16794368)
2006
28
Establishment and characterization of the RMG-V cell line from human ovarian clear cell adenocarcinoma. (17022146)
2005
29
WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma. (16134181)
2005
30
Irinotecan hydrochloride (CPT-11) and mitomycin C as the first line chemotherapy for ovarian clear cell adenocarcinoma. (15894369)
2005
31
Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses. (16203778)
2005
32
A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. (15350353)
2004
33
Antiproliferative effects of interferon-alphaCon1 on ovarian clear cell adenocarcinoma in vitro and in vivo. (15534119)
2004
34
Overexpression of HER-2/neu is not a risk factor in ovarian clear cell adenocarcinoma. (15350366)
2004
35
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
36
Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma: a special review for clear cell adenocarcinoma. (11790460)
2002
37
Absence of estrogen receptor-alpha expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. (11342781)
2001
38
Steroid sulfatase expression in ovarian clear cell adenocarcinoma: immunohistochemical study. (11520136)
2001
39
Hypercalcemia due to parathyroid hormone-related protein produced by primary ovarian clear cell adenocarcinoma: case report. (10637074)
2000
40
A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. (10563197)
1999
41
Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (10206285)
1999
42
Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas. (10091740)
1999
43
Survival probability in ovarian clear cell adenocarcinoma. (10385560)
1999
44
Remarkable suppressive effect of consecutive low-dose cisplatin therapy on advanced ovarian clear cell adenocarcinoma. (10425299)
1999
45
Appearance of primary endometrial and ovarian clear cell adenocarcinoma 17 months postpartum. A case report. (9622703)
1998
46
Establishment and characterization of two human ovarian clear cell adenocarcinoma lines from metastatic lesions with different properties. (7535723)
1995
47
Histologic correlates of progression-free interval and survival in ovarian clear cell adenocarcinoma. (8406197)
1993
48
Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. (1582751)
1992
49
Ovarian clear cell adenocarcinoma. (2920955)
1989
50
Establishment of HUOCA-II, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity. (2435943)
1987

Genetic Variations for Ovarian Clear Cell Adenocarcinoma

Expression for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Ovarian Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Sources:
52QIAGEN, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TUBB3, MET, ACTN4
2
Immune response IL-2 activation and signaling pathway
Hide members
10.1SMAD4, SMAD3, PIK3CA
310.1SMAD2, SMAD3, PIK3CA
4
Hide members
10.1SMAD2, SMAD3, PIK3CA
510.0SMAD4, SMAD2, SMAD3
6
Hide members
10.0SMAD4, SMAD2, SMAD3
710.0SMAD4, SMAD2, SMAD3
8
Hide members
10.0SMAD4, SMAD2, SMAD3
9
Development TGF-beta receptor signaling
Hide members
10.0SMAD4, SMAD2, SMAD3
1010.0SMAD4, SMAD2, SMAD3
11
Cytokine production by Th17 cells in CF (Mouse model)
10.0SMAD3, SMAD2, SMAD4
1210.0SMAD3, SMAD2, SMAD4
13
Hide members
10.0SMAD3, SMAD2, SMAD4
1410.0SMAD3, SMAD2, SMAD4
1510.0SMAD4, SMAD2, INHBA
1610.0SMAD4, SMAD3, INHBA
1710.0PIK3CA, MET, SMAD3, SMAD2
18
Hide members
9.9PIK3CA, SMAD3, SMAD2, SMAD4
19
Hide members
9.9PIK3CA, SMAD3, SMAD2, SMAD4
20
Hide members
9.9PIK3CA, SMAD3, SMAD2, SMAD4
219.9SMAD4, SMAD2, SMAD3, PIK3CA
229.9ESR2, SMAD3, SMAD2, SMAD4
239.9AFP, SMAD3, SMAD2, SMAD4
249.9SMAD4, SMAD2, SMAD3, INHBA
25
Hide members
9.9INHBA, SMAD3, SMAD2, SMAD4
269.9INHBA, SMAD3, SMAD2, SMAD4
279.8MET, ACTN4, SMAD3, SMAD2, SMAD4
28
Hide members
9.7AHR, INHBA, SMAD3, SMAD2, SMAD4
299.5SMAD4, SMAD2, ESR2, INHBA, STMN1, PIK3CA

Compounds for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4510.4MAP4, AHR
2crcs4510.4SMAD4, MET, PIK3CA
3progestin4510.3STS, AHR, PTHLH, ESR2
4bleomycin45 1111.3AFP, PTHLH, SMAD3, SMAD2
5arsenite45 2411.3PIK3CA, STS, AHR
6nocodazole45 1111.2SMAD2, PTHLH, MAP4, STMN1
7agar4510.2SMAD4, PTHLH, AFP, MET, PIK3CA
8leptomycin b45 6011.2AHR, PTHLH, SMAD3, SMAD2, SMAD4
9estrone45 29 11 2413.2STS, AFP, AHR, ESR2
10kaempferol4510.2ESR2, AHR
11ccl445 2911.2PTHLH, AFP, MET
12tgf beta14510.2AFP, PTHLH, SMAD3, SMAD2, SMAD4
13matrigel4510.2SMAD2, SMAD3, PTHLH, MET, PIK3CA
14paclitaxel45 50 1112.2TUBB3, PIK3CA, STMN1, AFP, MAP4
15dmso4510.2TUBB3, PIK3CA, AFP, AHR, ESR2
16dihydrotestosterone45 29 11 2413.1STS, PTHLH, ESR2, SMAD3, SMAD2, SMAD4
17tamoxifen45 50 29 1113.1PIK3CA, STS, AHR, PTHLH, ESR2
18cisplatin45 50 60 1113.1TUBB3, PIK3CA, STMN1, MET, AFP, PTHLH
19actinomycin d4510.1PIK3CA, MET, AFP, AHR, PTHLH, ESR2
20thyroxine45 2411.1PTHLH, GPX3, AHR, AFP
21etoposide45 50 60 1113.1WT1, PIK3CA, AFP, ESR2, SMAD3
22dexamethasone45 50 29 1113.1PIK3CA, AFP, AHR, GPX3, SMAD2
23paraffin4510.1WT1, MET, AFP, PTHLH, ESR2, SMAD4
24pd 98,0594510.1PIK3CA, STMN1, MET, SMAD3, SMAD2, SMAD4
25steroid4510.0WT1, PIK3CA, STS, AFP, AHR, PTHLH
26vitamin d4510.0WT1, MET, AFP, AHR, PTHLH, ESR2
27heparin45 29 11 2413.0PTHLH, GPX3, ANXA4, AFP, MET, PIK3CA
28doxorubicin45 50 1111.9WT1, PIK3CA, STMN1, MET, AFP, MAP4
29estradiol45 11 2411.9STS, AFP, AHR, GPX3, PTHLH, ESR2
30chloramphenicol45 2 1111.9WT1, AFP, ESR2, SMAD4
31cholesterol45 29 11 2412.9HNF1B, PIK3CA, STS, MET, AFP, GPX3
32lysine459.9WT1, ANXA4, PTHLH, SMAD3, SMAD2
33map445 2910.9MAP4, STMN1
34glucose459.8HNF1B, PIK3CA, MET, GPX3, PTHLH, SMAD3
35progesterone45 60 29 11 2413.8WT1, PIK3CA, STS, STMN1, MET, AFP
36thymidine45 2410.8WT1, PIK3CA, STMN1, MET, AFP, PTHLH
37cysteine459.8WT1, STS, MET, ANXA4, AHR, ESR2
38nitric oxide45 11 2411.7TUBB3, WT1, PIK3CA, MET, GPX3, PTHLH
39creatinine459.7WT1, STMN1, AFP, GPX3, PTHLH
40serine459.7STS, PIK3CA, WT1, TUBB3, STMN1, AFP
41lipid459.7PIK3CA, STS, MET, AFP, ANXA4, GPX3
42threonine459.7MET, STMN1, PIK3CA, WT1, AFP, ACTN4
43arginine459.6MET, PIK3CA, WT1, HNF1B, ANXA4, AHR
44vegf459.6WT1, PIK3CA, MET, AFP, AHR, PTHLH
45oligonucleotide459.6HNF1B, WT1, STS, STMN1, MET, AFP
46alanine459.6MET, AFP, MAP4, AHR, GPX3, PTHLH
47retinoic acid45 2410.6PIK3CA, WT1, TUBB3, HNF1B, STS, STMN1
48calcium45 50 11 2412.5TUBB3, PIK3CA, STS, STMN1, MET, AFP
49testosterone45 60 11 2412.5SMAD4, WT1, PIK3CA, STS, MET, AFP
50tyrosine459.3STMN1, STS, PIK3CA, WT1, TUBB3, MET

GO Terms for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein complexGO:07114110.0SMAD4, SMAD2, SMAD3
2activin responsive factor complexGO:0324449.9SMAD4, SMAD2
3transcription factor complexGO:0056679.7HNF1B, AHR, SMAD3, SMAD2, SMAD4
4cytoplasmGO:0057378.9WT1, AFP, ANXA4, MAP4, AHR, ACTN4

Biological processes related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1paraxial mesoderm morphogenesisGO:04834010.4SMAD2, SMAD3
2regulation of bindingGO:05109810.4SMAD4, SMAD2, SMAD3
3regulation of transforming growth factor beta2 productionGO:03290910.4SMAD4, SMAD3
4SMAD protein complex assemblyGO:00718310.4SMAD3, SMAD2, SMAD4
5endoderm developmentGO:00749210.4PTHLH, SMAD3, SMAD4
6regulation of transforming growth factor beta receptor signaling pathwayGO:01701510.4SMAD4, SMAD2, SMAD3
7positive regulation of epithelial to mesenchymal transitionGO:01071810.3SMAD4, SMAD2, SMAD3
8activin receptor signaling pathwayGO:03292410.3INHBA, SMAD3, SMAD2
9primary miRNA processingGO:03105310.3SMAD2, SMAD3
10developmental growthGO:04858910.3SMAD3, SMAD2, SMAD4
11ureteric bud developmentGO:00165710.3SMAD2, SMAD3, WT1
12positive regulation of cellular component movementGO:05127210.3ACTN4, STMN1
13nodal signaling pathwayGO:03809210.2SMAD3, SMAD2
14negative regulation of cell growthGO:03030810.1SMAD4, SMAD3, ESR2, INHBA, WT1
15pericardium developmentGO:06003910.1SMAD3, SMAD2
16palate developmentGO:06002110.0SMAD4, SMAD2, INHBA
17transcription initiation from RNA polymerase II promoterGO:00636710.0ESR2, SMAD3, SMAD2, SMAD4
18negative regulation of cell proliferationGO:00828510.0WT1, INHBA, PTHLH, SMAD2, SMAD4
19positive regulation of transcription, DNA-dependentGO:0458939.9SMAD4, SMAD2, SMAD3, INHBA, WT1, HNF1B
20embryonic foregut morphogenesisGO:0486179.9SMAD2, SMAD3
21negative regulation of transcription from RNA polymerase II promoterGO:0001229.8SMAD4, SMAD2, SMAD3, ESR2, AHR, WT1
22positive regulation of transcription from RNA polymerase II promoterGO:0459449.8HNF1B, MET, INHBA, SMAD3, SMAD2, SMAD4

Molecular functions related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityGO:03061810.4SMAD2, SMAD3
2R-SMAD bindingGO:07041210.3SMAD3, SMAD2, SMAD4
3I-SMAD bindingGO:07041110.3SMAD4, SMAD2
4core promoter proximal region sequence-specific DNA bindingGO:00098710.2SMAD4, SMAD3
5co-SMAD bindingGO:07041010.2SMAD3, SMAD2
6transforming growth factor beta receptor bindingGO:00516010.1SMAD3, SMAD2
7transcription regulatory region DNA bindingGO:04421210.0SMAD4, SMAD3, AHR, WT1, HNF1B
8transcription factor bindingGO:00813410.0AHR, GPX3, SMAD3, SMAD2
9sequence-specific DNA bindingGO:0435659.9HNF1B, WT1, AHR, SMAD3, SMAD4
10protein binding transcription factor activityGO:0009889.9SMAD4, SMAD3
11sequence-specific DNA binding transcription factor activityGO:0037009.7HNF1B, WT1, AHR, ESR2, SMAD3, SMAD2
12protein bindingGO:0055158.9NEU4, MET, PIK3CA, WT1, HNF1B, MAP4

Products for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Sources for Ovarian Clear Cell Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet