MCID: OVR034
MIFTS: 35

Ovarian Clear Cell Adenocarcinoma malady

Cancer diseases category
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Summaries for Ovarian Clear Cell Adenocarcinoma

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MalaCards based summary: Ovarian Clear Cell Adenocarcinoma is related to adenocarcinoma and endometriosis. An important gene associated with Ovarian Clear Cell Adenocarcinoma is HOXA10 (homeobox A10), and among its related pathways is Selected targets of HNF1. The compounds diethylstilbestrol and isoflavone have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Ovarian Clear Cell Adenocarcinoma

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Ovarian Clear Cell Adenocarcinoma, Aliases & Descriptions:

Name: Ovarian Clear Cell Adenocarcinoma 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5304
NCIt39 C40078

Related Diseases for Ovarian Clear Cell Adenocarcinoma

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Graphical network of the top 20 diseases related to Ovarian Clear Cell Adenocarcinoma:



Diseases related to ovarian clear cell adenocarcinoma

Symptoms for Ovarian Clear Cell Adenocarcinoma

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Drugs & Therapeutics for Ovarian Clear Cell Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Ovarian Clear Cell Adenocarcinoma

Search NIH Clinical Center for Ovarian Clear Cell Adenocarcinoma

Genetic Tests for Ovarian Clear Cell Adenocarcinoma

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Anatomical Context for Ovarian Clear Cell Adenocarcinoma

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MalaCards organs/tissues related to Ovarian Clear Cell Adenocarcinoma:

32
Ovary

Animal Models for Ovarian Clear Cell Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Clear Cell Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2ESR2, PTHLH, HOXA10
2MP:00053798.4HNF1B, ESR2, PTHLH, HOXA10

Publications for Ovarian Clear Cell Adenocarcinoma

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Articles related to Ovarian Clear Cell Adenocarcinoma:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. (24669262)
2014
2
Maximum standardized uptake value of fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in ovarian clear cell adenocarcinoma. (24987918)
2014
3
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. (24504419)
2014
4
Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice. (25398420)
2014
5
Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma. (24815386)
2014
6
Mass Spectrometric Analysis of the Phosphorylation Levels of the SWI/SNF Chromatin Remodeling/Tumor Suppressor Proteins ARID1A and Brg1 in Ovarian Clear Cell Adenocarcinoma Cell Lines. (25083560)
2014
7
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. (23726144)
2013
8
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. (24244679)
2013
9
Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene. (23430509)
2013
10
Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma. (23805888)
2013
11
Stathmin Regulates Hypoxia-Inducible Factor-1I+ Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma. (23819061)
2013
12
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. (23469222)
2013
13
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. (22348389)
2012
14
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1I+, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. (22498943)
2012
15
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. (22120431)
2012
16
Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture. (22317866)
2012
17
Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. (22871047)
2012
18
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. (21457161)
2011
19
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. (21348943)
2011
20
Re-expression of estrogen receptor I^ inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. (21874257)
2011
21
Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma. (22335020)
2011
22
Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group. (21293288)
2011
23
Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma. (21804390)
2011
24
PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (21735444)
2011
25
Analysis of mTOR inhibition-involved pathway in ovarian clear cell adenocarcinoma. (21614172)
2011
26
Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. (20546339)
2010
27
HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival. (20009888)
2009
28
A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: potential new therapy for ovarian clear cell adenocarcinoma. (18048092)
2008
29
Obstructive uropathy as a major presentation of ovarian clear cell adenocarcinoma. (18400599)
2008
30
Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics. (17592265)
2007
31
Specific expression of hepatocyte nuclear factor-1beta in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis. (17270029)
2007
32
Irinotecan hydrochloride (CPT-11) and cisplatin as first-line chemotherapy after initial surgery for ovarian clear cell adenocarcinoma. (18050828)
2007
33
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report. (17624099)
2007
34
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma. (16391844)
2006
35
Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis. (16442693)
2006
36
The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells. (16820918)
2006
37
Proteomic search for potential diagnostic markers and therapeutic targets for ovarian clear cell adenocarcinoma. (17022098)
2006
38
Establishment and characterization of the RMG-V cell line from human ovarian clear cell adenocarcinoma. (17022146)
2005
39
Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells. (12114452)
2002
40
Complete response to radiation therapy in a patient with chemotherapy-resistant ovarian clear cell adenocarcinoma. (12439556)
2002
41
Absence of estrogen receptor-alpha expression in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. (11342781)
2001
42
Hypercalcemia due to parathyroid hormone-related protein produced by primary ovarian clear cell adenocarcinoma: case report. (10637074)
2000
43
A pilot study of CPT-11 and cisplatin for ovarian clear cell adenocarcinoma. (10563197)
1999
44
Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (10206285)
1999
45
Appearance of primary endometrial and ovarian clear cell adenocarcinoma 17 months postpartum. A case report. (9622703)
1998
46
Establishment and characterization of two human ovarian clear cell adenocarcinoma lines from metastatic lesions with different properties. (7535723)
1995
47
Histologic correlates of progression-free interval and survival in ovarian clear cell adenocarcinoma. (8406197)
1993
48
Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. (1582751)
1992
49
Ovarian clear cell adenocarcinoma. (2920955)
1989
50
Establishment of HUOCA-II, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity. (2435943)
1987

Variations for Ovarian Clear Cell Adenocarcinoma

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Expression for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Ovarian Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Ovarian Clear Cell Adenocarcinoma.

Pathways for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Pathways related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4HNF1B, IGFBP1

Compounds for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Compounds related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1diethylstilbestrol44 28 1111.9ESR2, HOXA10
2isoflavone449.7ESR2, IGFBP1
3anastrozole44 50 1111.7ESR2, IGFBP1
4clomiphene citrate449.7IGFBP1, ESR2
5octreotide44 61 28 1112.7PTHLH, IGFBP1
6nocodazole44 1110.7STMN1, PTHLH
7rsai449.7IGFBP1, ESR2
8levonorgestrel44 61 28 1112.7ESR2, IGFBP1
9dbc-amp449.7IGFBP1, PTHLH
10androstenedione44 2410.6ESR2, IGFBP1
11letrozole44 50 61 1112.5ESR2, STS
12steroidal449.5STS, ESR2
13phenol44 2410.5STS, ESR2
14mifepristone44 28 61 1112.5ESR2, IGFBP1
153beta-hydroxysteroid449.5ESR2, STS
1617beta-hydroxysteroid449.5STS, ESR2
17prednisolone44 28 1111.4PTHLH, IGFBP1
18rosiglitazone28 44 50 24 1113.4PTHLH, IGFBP1
192-methoxyestradiol44 61 2411.4STS, ESR2
204-hydroxytamoxifen449.4STS, ESR2
21lead449.4STS, PTHLH
22dehydroepiandrosterone sulfate449.4STS, IGFBP1
23hydrocortisone44 2 61 1112.3PTHLH, IGFBP1
24ribonucleic acid449.3ESR2, PTHLH, IGFBP1
25vitamin d449.3IGFBP1, PTHLH, ESR2
26actinomycin d449.3IGFBP1, PTHLH, ESR2
27forskolin44 50 1111.3STMN1, PTHLH, IGFBP1
28thymidine44 2410.2IGFBP1, PTHLH, STMN1
29creatinine449.2STMN1, PTHLH, IGFBP1
30dexamethasone44 50 28 1112.0IGFBP1, PTHLH, ESR2
31cycloheximide449.0HOXA10, IGFBP1, PTHLH, ESR2
32progestins448.9IGFBP1, ESR2, STS
33dhea448.9STS, ESR2, IGFBP1
34estrone44 28 24 1111.9STS, ESR2, IGFBP1
35arginine448.9IGFBP1, PTHLH, ESR2, HNF1B
36cholesterol44 28 24 1111.8IGFBP1, STS, HNF1B
37oligonucleotide448.7HOXA10, STMN1, STS, HNF1B
38vegf448.6IGFBP1, PTHLH, ESR2
39tyrosine448.6STS, STMN1, PTHLH, HOXA10
40progestin448.5IGFBP1, PTHLH, ESR2, STS
41dihydrotestosterone44 28 24 1111.5IGFBP1, PTHLH, ESR2, STS
42tamoxifen44 50 28 1111.5STS, ESR2, PTHLH, IGFBP1
43oxygen44 249.5IGFBP1, PTHLH, STMN1, STS
44estradiol44 24 1110.2HOXA10, IGFBP1, PTHLH, ESR2, STS
45testosterone44 61 24 1111.2STS, ESR2, PTHLH, IGFBP1, HOXA10
46steroid448.2HOXA10, IGFBP1, PTHLH, ESR2, STS
47serine448.0STS, STMN1, ESR2, PTHLH, IGFBP1
48progesterone44 28 61 24 1111.7STS, STMN1, ESR2, PTHLH, IGFBP1, HOXA10
49estrogen447.7HOXA10, IGFBP1, PTHLH, ESR2, STMN1, STS
50retinoic acid44 248.6IGFBP1, PTHLH, ESR2, STMN1, STS, HNF1B

GO Terms for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Biological processes related to Ovarian Clear Cell Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.7PTHLH, HOXA10
2anterior/posterior pattern specificationGO:0099529.3HNF1B, HOXA10
3epidermis developmentGO:0085449.2STS, PTHLH
4female pregnancyGO:0075659.1STS, PTHLH

Products for genes affiliated with Ovarian Clear Cell Adenocarcinoma

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Sources for Ovarian Clear Cell Adenocarcinoma

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3CDC
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14FMA
22GTR
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24HMDB
25ICD10
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28IUPHAR
29KEGG
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36MGI
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62UMLS
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