MCID: OVR046
MIFTS: 50

Ovarian Cyst malady

Summaries for Ovarian Cyst

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A cyst is a fluid-filled sac. in most cases a cyst on the ovary does no harm and goes away by itself. most women have them sometime during their lives. cysts are rarely cancerous in women under 50. cysts sometimes hurt - but not always. often, a woman finds out about a cyst when she has a pelvic exam. if you're in your childbearing years or past menopause, have no symptoms, and have a fluid-filled cyst, you may choose to monitor the cyst. you may need surgery if you have pain, are past menopause or if the cyst does not go away. birth control pills can help prevent new cysts. a health problem that may involve ovarian cysts is polycystic ovary syndrome (pcos). women with pcos can have high levels of male hormones, irregular or no periods and small ovarian cysts. dept. of health and human services office on women's health

MalaCards: Ovarian Cyst, also known as ovarian cysts, is related to ovarian cancer and peritonitis. An important gene associated with Ovarian Cyst is PRSS2 (protease, serine, 2 (trypsin 2)), and among its related pathways are Glycoprotein hormones and Estrogen biosynthesis. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial, and related mouse phenotype endocrine/exocrine gland.

Wikipedia:63 An ovarian cyst is any collection of fluid, surrounded by a very thin wall, within an ovary. Any ovarian... more...

Aliases & Classifications for Ovarian Cyst

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

ovarian cyst 8
ovarian cysts 44 33 60


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Disease Ontology8 DOID:5119
SNOMED-CT56 198586000
ICD9CM27 620.2

Related Diseases for Ovarian Cyst

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17GeneCards, 18GeneDecks
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Diseases in the Ovarian Cyst family:

Malignant Ovarian Cyst

Diseases related to Ovarian Cyst via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer30.8ESR2, SPINK1, PAEP, MMP13, MUC16, IGFBP2
2peritonitis30.5MMP8, MUC16
3hypothyroidism30.5GNAS, GNRH1, CGA
4mccune albright syndrome30.4GNAS, GNRH1
5breast cyst30.4CGB5, CYP19A1
6ovarian disease30.4CGA, GNRH1
7leiomyoma30.3GNRH1, CYP19A1, PAEP, ESR2
8ovarian hyperstimulation syndrome30.3GNRH1, CGA, CGB5, CYP19A1
9breast cancer30.3GNRH1, IGFBP2, MUC16, CYP19A1, MMP13, MMP8
10endometriosis30.2GNRH1, CGA, MUC16, CYP19A1, MMP1, PAEP
11adenoma30.2GNAS, GNRH1, CGA, IGFBP2, CNC, PAEP
12pancreatitis30.1PRSS2, SPINK1
13obesity30.1GNAS, IGFBP2
14thyroiditis29.9CGA
15uterine fibroid29.9GNRH1
16ovarian serous cystadenocarcinoma29.9MUC16
17cystadenocarcinoma29.9CEACAM3, MUC16
18corpus luteum cyst29.9CGB5, MUC16
19diabetes mellitus29.9IGFBP2, SPINK1, ESR2
20anovulation29.9GNRH1, CGA, CYP19A1
21colon cancer29.9IGFBP2, MMP13, SPINK1, ESR2, CEACAM3
22pituitary adenoma29.9ESR2, CNC, CGA, GNRH1, GNAS
23adenocarcinoma29.9CGB5, IGFBP2, MUC16, MMP13, PAEP, SPINK1
24malignant ovarian cyst10.5
25meningocele10.3
26neonatal ovarian cyst10.3
27ovarian endometriosis10.2
28congenital adrenal hyperplasia10.2
29polyhydramnios10.2
30cervicitis10.2
31pulmonary embolism10.2
32vaginitis10.2
33hydronephrosis10.1
34mucocele of appendix10.1
35bladder diverticulum10.1
36endometritis10.1
37intestinal obstruction10.1
38hypogonadotropism10.0GNRH1
39amenorrhea10.0GNRH1
40male infertility10.0GNRH1
41growth hormone deficiency10.0IGFBP2
42sarcoma10.0CGB5
43leiomyosarcoma10.0MUC16
44turner syndrome10.0GNRH1
45meningitis10.0IGFBP2
46gallbladder cancer10.0CEACAM3
47bronchogenic cyst10.0MUC16
48androgen insensitivity syndrome10.0CGA
49hepatitis10.0IGFBP2
50aromatase excess syndrome10.0CYP19A1

Graphical network of the top 20 diseases related to Ovarian Cyst:



Diseases related to ovarian cyst

Clinical Features for Ovarian Cyst

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Drugs & Therapeutics for Ovarian Cyst

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Ovarian Cyst

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Search CenterWatch for Ovarian Cyst

Genetic Tests for Ovarian Cyst

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Anatomical Context for Ovarian Cyst

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32MalaCards
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MalaCards organs/tissues related to Ovarian Cyst:

32
Ovary, Uterus, Endothelial, Pituitary, Breast, Colon, Kidney, Cervix, Bone, Liver, Thyroid, Appendix, Brain, Smooth muscle, Small intestine, Heart

Animal Models for Ovarian Cyst or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Cyst:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2ESR2, NOBOX

Publications for Ovarian Cyst

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50PubMed
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Articles related to Ovarian Cyst:

(show top 50)    (show all 618)
idTitleAuthorsYear
1
Impact of intracystic ethanol instillation on ovarian cyst diameter and adjacent ovarian tissue. (24411950)
2013
2
Preoperative differentiation between tumor-related ovarian torsion and rupture of ovarian cyst preoperatively diagnosed as benign: a retrospective study. (22690912)
2013
3
Ovarian hydatid cyst in pediatric patient commencing as ovarian tumor: a rare site of echinococcosis. (23272291)
2012
4
A giant ovarian cyst in a neonate with classical 21-hydroxylase deficiency with very high testosterone levels demonstrating a high-dose hook effect. (22664361)
2012
5
A study of ovarian cyst in a tertiary hospital of Kathmandu valley. (21991700)
2011
6
"Laparoscopic excision of a large ovarian cyst herniating into the inguinal canal: a rare presentation". (21857466)
2011
7
Antenatally diagnosed neonatal ovarian cyst with torsion. (21393934)
2011
8
Incidental diagnosis of a mesenteric cyst mimicking an ovarian cyst during laparoscopy. (22030062)
2011
9
Anterior sacral meningocele wrongly diagnosed as ovarian cyst. (21051926)
2010
10
Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. (20800980)
2010
11
Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors. (19915865)
2010
12
Torsion of ovarian cyst during pregnancy: a case report. (20090873)
2009
13
Laparoendoscopic single-site surgery (LESS) for ovarian cyst enucleation: report of first 3 cases. (19589520)
2009
14
Stillbirth due to placental hypoperfusion after salpingo-oophorectomy for an ovarian cyst. (17666636)
2007
15
Laparoscopic excision of a giant ovarian cyst after ultrasound-guided drainage. (17011259)
2006
16
Laparoscopic management of giant ovarian cyst. (16882432)
2006
17
Degenerating cystic uterine fibroid mimics an ovarian cyst in a pregnant patient. (16632793)
2006
18
Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. (15831296)
2005
19
Hemorrhagic ovarian cyst without peritoneal bleeding in a patient with ovarian hyperstimulation syndrome: case report. (16232339)
2005
20
Ultrasonographic and clinical appearance of hemorrhagic ovarian cyst diagnosed by transvaginal scan. (12928726)
2003
21
Torsion of a nongravid uterus: an unexpected complication of an ovarian cyst. (11574144)
2001
22
Postmenopausal virilization, simple ovarian cyst, and hilus cell hyperplasia--is there an association? (11250768)
2001
23
Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat. (10459564)
1999
24
Infected ovarian cyst in a homozygous beta-thalassemic patient. (10443102)
1999
25
Needle aspiration and ovarian cyst. (9438772)
1998
26
Choroidal cells in ovarian cyst fluid: a case report. (8629416)
1996
27
Large congenital follicular ovarian cyst in a girl with Kabuki syndrome. (8914748)
1996
28
Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. (8624265)
1996
29
Two cases of colo-ovarian cyst fistula. (7636374)
1995
30
The largest ovarian cyst in Songklanagarind Hospital: a case report. (7876767)
1994
31
Congenital ovarian cyst: report of one case. (8296561)
1993
32
Reply: Primary ovarian lymphoma and colloid cyst of anterior third ventricle complicating pregnancy. (17589164)
1992
33
Giant diverticulum of the bladder simulating ovarian cyst. (1683304)
1991
34
Nonmenstrual toxic shock syndrome after aspiration of an ovarian cyst. A case report. (1840073)
1991
35
Induction of ovarian follicular cysts in the pregnant rat by human chorionic gonadotropin. (1652291)
1991
36
Magnetic resonance imaging of the ovarian cyst: its diagnostic value of endometrial cyst. (2151665)
1990
37
The 'simple' ovarian cyst: aspirate or operate? (2679871)
1989
38
Induced fluid movement within a giant ovarian cyst demonstrated by echo-planar imaging. (2605457)
1989
39
Ovarian cyst of the newborn. (3303910)
1987
40
Early unwinding of torsion of an ovarian cyst as result of hyperstimulation syndrome. (6411500)
1983
41
Reproductive hormones associated with the ovarian cyst response to GnRH. (16725437)
1979
42
Giant ovarian cyst in an infant: report of a case. (4538763)
1972
43
Ruptured ovarian cyst in the newborn. (5681672)
1968
44
Ovarian cyst following supracervical hysterectomy; report of a case. (13398651)
1957
45
Studies in immunochemistry. 17. The decomposition of serologically specific H substance isolated from pig gastric mucin and human ovarian cyst fluids by an enzyme preparation obtained from Closteridium welchii (type B.). (13403891)
1957
46
Giant ovarian cyst of the newborn; report of a case. (13272786)
1955
47
Ovarian cyst with twisted pedicle complicating pregnancy. (13192338)
1954
48
Ovarian cyst in the transverse mesocolon; report of a case. (12990996)
1952
49
Ruptured ovarian cyst as a cause of massive intraabdominal hemorrhage; report of five cases. (15399002)
1950
50
Unusually large ovarian cyst in an elderly woman. (20281953)
1947

Genetic Variations for Ovarian Cyst

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Expression for genes affiliated with Ovarian Cyst

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cyst

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Pathways for genes affiliated with Ovarian Cyst

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53Reactome, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Ovarian Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CGA, GNRH1
2
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10.2CYP19A1, ESR2
3
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10.1PRSS2, MMP8, MMP13
4
Cell adhesion ECM remodeling
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10.1MMP8, MMP13, MMP1
5
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10.1MMP13, MMP8, MMP1
610.1GNAS, CGA, CYP19A1
7
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10.0PRSS2, MMP13, MMP8, MMP1
8
Development Endothelin-1/EDNRA signaling
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10.0GNRH1, CGA, ESR2, GNAS
9
Hide members
9.9MMP1, MMP8, MMP13, CGA, GNRH1
10
Hide members
9.8GNAS, GNRH1, CGA, PRSS2, GPR34

Compounds for genes affiliated with Ovarian Cyst

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Ovarian Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7PAEP
2pge24410.7PAEP
3nafarelin44 59 28 1113.4GNRH1, CYP19A1, CGA
4cycloheximide4410.4IGFBP2, CGB5
5clodronate44 49 1112.4CGA, MMP1, MMP13, MMP8
6tibolone4410.3MMP1, GNRH1, CYP19A1, PAEP
7lutein4410.3CYP19A1, MMP1, CGA, CGB5
8levonorgestrel44 59 28 1113.3CYP19A1, MMP1, PAEP, ESR2
9steroidal4410.3IGFBP2, CYP19A1, ESR2, GNRH1
10bicalutamide44 59 1112.3ESR2, CYP19A1, IGFBP2, GNRH1
11goserelin44 28 1112.2CGA, GNRH1
12(4-aminophenyl)mercuric acetate4410.2MMP13, MMP8
13dexamethasone44 49 28 1113.2MMP13, MUC16, GNRH1, CGB5
14estradiol benzoate4410.2CGB5, CGA, GNRH1, ESR2, CYP19A1
15leuprolide acetate4410.2GNRH1, CGA, ESR2, CGB5, CYP19A1
16diethylstilbestrol44 28 1112.2CYP19A1, CGA, GNRH1, CGB5, ESR2
17buserelin44 28 1112.2CGB5, CYP19A1, PAEP, GNRH1, CGA
18progestins4410.2PAEP, CYP19A1, IGFBP2, ESR2, GNRH1
19trilostane44 1111.2CGA, CGB5, ESR2
20leuprolide44 59 28 1113.2GNRH1, CGB5, CGA
21sialic acid4410.2CEACAM3, PAEP, CGA, GNAS
22dehydroepiandrosterone sulfate4410.1GNRH1, CYP19A1, CGA, CGB5
233beta-hydroxysteroid4410.1CGA, CGB5, CYP19A1, ESR2
24estrone44 28 11 2413.1ESR2, CGB5, GNRH1, IGFBP2, CYP19A1
25clomiphene citrate4410.1ESR2, CYP19A1, GNRH1, CGB5, CGA, PAEP
2617beta-hydroxysteroid4410.1ESR2, CGA, CYP19A1, CGB5
2717-hydroxyprogesterone44 2411.1CYP19A1, GNRH1, MUC16, IGFBP2, CGB5, CGA
28dihydrotestosterone44 28 11 2413.1GNRH1, CGB5, ESR2, IGFBP2, CYP19A1, CGA
29mifepristone44 59 28 1113.0GNRH1, ESR2, PAEP, MMP1, CYP19A1, CGB5
30androstenedione44 2410.9PAEP, CYP19A1, IGFBP2, CGB5, CGA, GNRH1
31gnrh449.9GNAS, IGFBP2, CGB5, CGA, GNRH1, CYP19A1
32genistein44 28 59 2 11 2414.9ESR2, PAEP, MMP1, MMP8, MMP13, CYP19A1
33serine449.9GNAS, SPINK1, CGA, MUC16, MMP1, MMP13
34prostaglandin449.9CGB5, PAEP, MMP1, MMP13, CGA
35prostaglandin f2alpha449.8GNRH1, CGA, CGB5, MMP1
36fibrinogen449.8IGFBP2, CEACAM3, MMP8, MMP13, MUC16, CGB5
37paraffin449.8MUC16, MMP13, CGB5, MMP1, ESR2, CEACAM3
38progestin449.8MMP1, GNRH1, CGA, CGB5, IGFBP2, CYP19A1
39doxorubicin44 49 1111.8CGB5, MUC16, CYP19A1, MMP1, ESR2, CEACAM3
40lactate449.8CGB5, MMP1, GNRH1, CGA, MMP8, CEACAM3
41creatinine449.8CEACAM3, MMP1, CGB5, SPINK1, GNRH1, CGA
42tamoxifen44 49 28 1112.7IGFBP2, ESR2, PAEP, CYP19A1, CGB5, CGA
43ribonucleic acid449.7ESR2, MMP1, PAEP, MMP13, IGFBP2, CGB5
44testosterone44 59 11 2412.6ESR2, CYP19A1, GNRH1, CGA, CGB5, IGFBP2
45retinoic acid44 2410.6MMP13, MMP8, MMP1, PAEP, CYP19A1, IGFBP2
46estradiol44 11 2411.6GNRH1, IGFBP2, MUC16, CYP19A1, MMP13, CGB5
47vegf449.5MUC16, ESR2, PAEP, MMP1, MMP8, MMP13
48steroid449.5GNAS, CYP19A1, IGFBP2, GNRH1, PAEP, ESR2
49acth449.4CGB5, GNRH1, IGFBP2, CEACAM3, GNAS
50progesterone44 59 28 11 2413.2MUC16, GNAS, CEACAM3, ESR2, PAEP, MMP8

GO Terms for genes affiliated with Ovarian Cyst

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16Gene Ontology
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Cellular components related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7PRSS2, IGFBP2, MUC16, MMP13, MMP8, GNRH1
2extracellular regionGO:0055768.8ESR2, GNAS, GNRH1, CGA, PRSS2, IGFBP2

Biological processes related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057410.1MMP8, MMP1, MMP13, PRSS2
2extracellular matrix disassemblyGO:02261710.0PRSS2, MMP13, MMP8, MMP1
3extracellular matrix organizationGO:03019810.0MMP13, MMP8, MMP1, PRSS2
4female pregnancyGO:0075659.8IGFBP2, GNAS, GNRH1
5cellular protein metabolic processGO:0442679.7MMP13, MMP1, MUC16, IGFBP2, CGA

Molecular functions related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.1MMP1, MMP8, MMP13

Products for genes affiliated with Ovarian Cyst

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Sources for Ovarian Cyst

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet