Ovarian Cyst malady

MedlinePlus: A cyst is a fluid-filled sac. in most cases a cyst on the ovary does no harm and goes away by itself. most women have them sometime during their lives. cysts are rarely cancerous in women under 50. cysts sometimes hurt - but not always. often, a woman finds out about a cyst when she has a pelvic exam. if you're in your childbearing years or past menopause, have no symptoms, and have a fluid-filled cyst, you may choose to monitor the cyst. you may need surgery if you have pain, are past menopause or if the cyst does not go away. birth control pills can help prevent new cysts. a health problem that may involve ovarian cysts is polycystic ovary syndrome (pcos). women with pcos can have high levels of male hormones, irregular or no periods and small ovarian cysts. dept. of health and human services office on women's health²³

MalaCards: Ovarian Cyst, also known as ovarian cysts, is related to malignant ovarian cyst and corpus luteum cyst. An important gene associated with Ovarian Cyst is IGFBP2 (insulin-like growth factor binding protein 2, 36kDa), and among its related pathways are Glioma Invasiveness and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. The compounds toremifene and 17-hydroxyprogesterone have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and endothelial, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Wikipedia: An ovarian cyst is any collection of fluid, surrounded by a very thin wall, within an ovary. Any ovarian...⁴⁴ more...

Aliases & Descriptions:

ovarian cyst 6 ovarian cysts 32 23 43

Diseases related to ovarian cyst by text searches and GeneDecks gene sharing:

(show top 50)    (show all 481)

id	Related Disease	Score	Top Affiliating Genes
1	malignant ovarian cyst	32.3	MMP1, MMP13, MMP8, IGFBP2, PRSS2
2	corpus luteum cyst	29.3	MUC16, CGB5, FOXL2
3	fragile x-associated primary ovarian insufficiency	28.4	CGA, FOXL2, GNRH1, CYP19A1, PRL
4	virilization	28.3	CGA, CGB5, IGFBP2, GNRH1, HSD3BP4, CYP19A1
5	breast cancer	26.8	ESR1, ESR2, CYP19A1, EGF, TFF1, PRL
6	ovarian cancer	20.4	VEGFA, PAEP, MUC16, CGA, CGB5, CEACAM3
7	bronchogenic cyst	13.7	MUC16, CEACAM3
8	leydig cell adenoma	13.7	CGA, GNRH1
9	ectopic pregnancy	13.6	PAEP, CGA, CGB5
10	micropenis	13.6	CGA, CGB5, GNRH1
11	ovarian mixed germ cell neoplasm	13.6	CGA, AFP
12	cutis marmorata telangiectatica congenita	13.6	CGA, AFP
13	polyembryoma	13.6	CGA, AFP
14	aorta atresia	13.5	CGA, IGFBP2, GNRH1, CYP19A1
15	gestational trophoblastic neoplasm	13.5	PAEP, CGA, CGB5
16	sycp3-related pregnancy loss, susceptibility to	13.5	CGA, CGB5, GNRH1
17	primary ciliary dyskinesia	13.5	CGA, CYP19A1
18	aromatase excess syndrome	13.5	CGB5, CYP19A1
19	malignant germ cell tumor	13.5	CGB5, AFP
20	malignant sertoli cell tumor	13.5	CGB5, AFP
21	mucinous cystadenocarcinoma	13.5	MUC16, CEACAM7, CEACAM3
22	nonseminomatous germ cell tumor	13.5	CGA, CGB5, AFP
23	metaphyseal anadysplasia	13.5	MMP13, MMP9
24	sacrococcygeal teratoma	13.5	MUC16, CGA, AFP
25	endodermal sinus tumor	13.5	MUC16, CGB5, AFP
26	male infertility	13.4	CGA, GNRH1, ESR2, CYP19A1
27	malignant pleural mesothelioma	13.4	MUC16, CEACAM7, CEACAM3
28	androgen insensitivity syndrome	13.4	CGA, IGFBP2, CYP19A1
29	anencephaly	13.4	CGA, CGB5, AFP
30	21-hydroxylase deficiency	13.4	GNRH1, HSD3BP4, CYP19A1
31	large cell carcinoma	13.4	CGB5, CEACAM7, CEACAM3
32	ovarian sex cord tumors	13.4	MUC16, CEACAM3, CYP19A1, AFP
33	keloids	13.3	MMP1, MMP13, MMP8
34	hypothalamic disease	13.3	CGA, GNRH1, PRL
35	neural tube defect	13.3	CGA, CGB5, AFP
36	sertoli cell tumor	13.3	CGB5, CYP19A1, AFP
37	adrenocortical carcinoma	13.3	IGFBP2, HSD3BP4, CYP19A1, ADM
38	oligohydramnios	13.2	CGA, ADM, AFP
39	sexual disorder	13.2	GNRH1, PRL
40	periodontitis	13.2	MMP1, MMP13, MMP8, MMP9
41	carney complex	13.2	CNC, GNAS, PRL
42	tongue cancer	13.2	MMP2, MMP8, MMP9
43	breast cyst	13.2	CGB5, CYP19A1, EGF
44	kallmann syndrome	13.2	CGA, CGB5, GNRH1, PLAU
45	adrenal gland hyperfunction	13.2	CNC, HSD3BP4, PRL
46	gonadotropin deficiency	13.2	CGA, GNRH1, CYP19A1, PRL
47	y chromosome infertility	13.2	CGA, CGB5, GNRH1, PRL
48	mccune albright syndrome	13.2	GNAS, PRL
49	catamenial pneumothorax	13.2	MUC16, GNRH1, ESR1
50	parotitis	13.2	MMP2, MMP9, SPINK1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ovarian cyst:

²²

MGI Mouse Phenotypes related to ovarian cyst:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	FOXL2, GNAS, GNRH1, NOBOX, AFP
2	immune system phenotype	MP:0005387	9.2	ADM, PRL, CYP19A1, GNRH1, GNAS, IGFBP2
3	liver/biliary system phenotype	MP:0005370	8.9	ADM, SLC25A13, PRL, CYP19A1, ESR2, VEGFA
4	integument phenotype	MP:0010771	8.5	PRL, EGF, CYP19A1, GNRH1, GNAS, GSTP1
5	reproductive system phenotype	MP:0005389	8.2	AFP, PRL, NOBOX, ESR2, GNRH1, FOXL2
6	renal/urinary system phenotype	MP:0005367	7.8	ADM, SLC25A13, ESR2, ESR1, GNRH1, GNAS
7	growth/size phenotype	MP:0005378	7.4	SLC25A13, EGF, PLAU, SPINK1, CYP19A1, ESR2
8	digestive/alimentary phenotype	MP:0005381	7.2	EGF, PLAU, SPINK1, ESR2, ESR1, GNRH1
9	skeleton phenotype	MP:0005390	7.0	PLAU, CYP19A1, ESR2, ESR1, GNRH1, GNAS
10	muscle phenotype	MP:0005369	6.9	ESR2, CYP19A1, PLAU, ADM, ESR1, GNAS
11	tumorigenesis	MP:0002006	6.7	ESR2, PLAU, TFF1, PRL, AFP, ESR1
12	cardiovascular system phenotype	MP:0005385	6.4	ESR1, ESR2, CYP19A1, PLAU, ADM, GNAS
13	homeostasis/metabolism phenotype	MP:0005376	5.4	ESR2, CYP19A1, SPINK1, PLAU, PRL, SLC25A13

Articles related to ovarian cyst:

(show all 37)

id	Title	Authors	Year	Affiliating Genes
1	Clinical, biological and genetic analysis of prepuber tal isolated ovarian cyst in 11 girls. (20593028)	Brauner R.... McElreavey K.	2010	NOBOX
2	GSTP1-1 in ovarian cyst fluid and disease outcome of patients with ovarian cancer. (19661073)	Kolwijck E.... Massuger L.F.	2009	GSTP1
3	Ovarian cysts in high-yielding dairy cows. (19559473)	Braw-Tal R.... Roth Z.	2009	IGF1
4	Precocious pseudopuberty due to autonomous ovarian cysts: a report of ten cases and long-term follow-up. (18477555)	de Sousa G.... Andler W.	2008	GNRH1
5	Giant ovarian cyst extraction by means of minilaparotomy: hourglass technique (19149403)	Guajado MartA-nez J.... Villeda C.	2008	SLC25A13
6	The impact of unabated stimulation by human chorionic gonadotropin on the steroid hormone environment of pregnant rats and the spontaneous expression of ovarian cysts in female progeny. (18481228)	Bogovich K.	2008	CGB5
7	Obligatory roles for follicle-stimulating hormone (FSH), estradiol and androgens in the induction of small polyfollicular ovarian cysts in hypophysectomized immature rats. (17873331)	Bogovich K.	2007	CGA
8	Association between milk production and treatment response of ovarian cysts in lactating dairy cows using the Ovsynch protocol. (16650468)	Crane M.B.... Archbald L.F.	2006	GNRH1
9	Measurement of glycodelin A in fluids of benign ovarian cysts, borderline tumours and malignant ovarian cancer. (16033074)	Bischof A.... Jeschke U.	2005	PAEP
10	A new heterozygous mutation of the FOXL2 gene is associated with a large ovarian cyst and ovarian dysfunction in an adolescent girl with blepharophimosis/ptosis/epicanthus inversus syndrome. (16131596)	Raile K.... Pfaffle R.	2005	FOXL2
11	Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts. (16213873)	Raspollini M.R.... Taddei G.L.	2005	MMP2, MMP9, MMP1
12	Neonatal ovarian cysts: management with reference to magnetic resonance imaging. (14719514)	Kuroiwa M.... Tsuchida Y.	2004	INTS10
13	Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts. (12743421)	Stenman M.... Sorsa T.	2003	MMP8, MMP13, MMP1
14	Neuroendocrine stress response in patients undergoing benign ovarian cyst surgery by laparoscopy, minilaparotomy, and laparotomy. (12732764)	Marana E.... Marana R.	2003	PRL
15	Expression of adrenomedullin in human ovaries, ovarian cysts and cancers. Correlation with estrogens receptor status. (12969589)	Giacalone P.L.... Maudelonde T.	2003	ESR1, ESR2, ADM
16	Clinical value of components of the plasminogen activation system in ovarian cyst fluid. (12017303)	Boss E.A.... Sweep C.G.	2002	PLAU
17	Laparoscopic extirpation of a giant ovarian cyst. (11967707)	Postma V.A.... Janssen I.M.	2002	AFP
18	Vascular endothelial growth factor in ovarian cyst fluid. (11180084)	Boss E.A.... Sweep C.G.	2001	VEGFA
19	Tumor markers and ovarian cysts (11917374)	Vinatier D.... Collinet P.	2001	MUC16
20	Role of ultrasound guided puncture in the management of ovarian cysts (11917376)	Mathevet P.... Dargent D.	2001	MUC16
21	Clinical study on endometrial ovarian cyst treated by integrated laparoscopy and Chinese herbal medicine (11789280)	Wu Y.... Jin Y.	2000	MUC16
22	Follow up of women with simple ovarian cysts detected by transvaginal sonography in the Tokyo metropolitan area. (10430190)	Sasaki H.... Tanaka T.	1999	MUC16
23	Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat. (10459564)	Bogovich K.... Poretsky L.	1999	CGA
24	Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy. (10213218)	Hazelton D.... Nicosia S.V.	1999	VEGFA
25	Modifications of receptor concentrations for adrenaline, steroid hormones, prostaglandin F2alpha and gonadotropins in hypophysis and ovary of dairy cows with ovarian cysts. (10208760)	Odore R.... Girardi C.	1999	ESR1
26	Differential diagnosis of peri- and postmenopausal ovarian cysts. (10227005)	Reimer T.... Friese K.	1999	EGF
27	Gonadotropin levels in ovarian cyst fluids: a predictor of malignancy? (10079392)	KrAomer S.... JAoger W.	1998	GNRH1
28	Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. (9866068)	Biljan M.M.... Tan S.L.	1998	GNRH1
29	Inhibin assays of ovarian cyst liquid obtained by needle aspiration may allow differential diagnosis between functional and organic cysts. (9228498)	Binelli C.... Alain D.	1997	MUC16
30	CA-125 and carcinoembryonic antigen assay vs. cytodiagnostic experience in the classification of benign ovarian cysts. (9305384)	Pinto M.M.... Garfinkel R.	1997	CEACAM3
31	Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. (8624265)	Kanety H.... Karasik A.	1996	IGFBP2
32	Expression of an estrogen-induced breast cancer-associated protein (pS2) in benign and malignant human ovarian cysts. (8078298)	Dante R.... Lasne Y.	1994	TFF1
33	Persistent elevation of serum oestradiol levels by functional ovarian cysts despite effective pituitary desensitization with GnRH agonists. (8187299)	Jenkins J.M.... Thomas E.	1994	GNRH1
34	Undetectable levels of serum FSH immunoactivity and b ioactivity in girls with sexual precocity due to ovarian cysts. (7919760)	Low L.C.... Leong L.Y.	1994	CYP19A1
35	Late-onset 3 beta-hydroxysteroid dehydrogenase defici ency with virilization induced by a large ovarian cyst. (8112725)	Heinrich U.... Otto H.F.	1993	HSD3BP4
36	Serous ovarian cyst fluids contain high levels of endometrial placental protein 14. (1626182)	Riittinen L.	1992	PAEP
37	Measurement of CA125, carcinoembryonic antigen, and alpha-fetoprotein in ovarian cyst fluid: diagnostic adjunct to cytology. (1696873)	Pinto M.M.... Lavy G.	1990	AFP, MUC16, CEACAM7

Genes related to ovarian cyst according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
2	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0
3	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
4	INTS10	integrator complex subunit 10	11.0	Publications
5	PAEP	progestagen-associated endometrial protein	11.0	Publications
6	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
7	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0
8	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
9	MUC16	mucin 16, cell surface associated	11.0	Publications
10	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
11	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
12	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
13	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
14	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
15	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
16	GNAS	GNAS complex locus	11.0
17	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
18	GPR34	G protein-coupled receptor 34	11.0
19	ADAD2	adenosine deaminase domain containing 2	11.0
20	NOBOX	NOBOX oogenesis homeobox	11.0	Publications
21	LGALS7	lectin, galactoside-binding, soluble, 7	11.0
22	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
23	FOXL2	forkhead box L2	11.0	Publications
24	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
25	TFF1	trefoil factor 1	11.0	Publications
26	ADM	adrenomedullin	11.0	Publications
27	SLC25A13	solute carrier family 25 (aspartate/glutamate carrier), member 13	11.0	Publications
28	AFP	alpha-fetoprotein	11.0	Publications
29	PLAU	plasminogen activator, urokinase	11.0	Publications
30	PRL	prolactin	11.0	Publications
31	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
32	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
33	GSTP1	glutathione S-transferase pi 1	11.0	Publications
34	VEGFA	vascular endothelial growth factor A	11.0	Publications
35	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
36	EGF	epidermal growth factor	11.0	Publications
37	ESR1	estrogen receptor 1	11.0	Publications

Pathways related to ovarian cyst according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Glioma Invasiveness36	9.9	PLAU, GNRH1
2	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	9.7	ESR1, ESR2, CYP19A1
3	GnRH signaling pathway20	9.6	CGA, MMP2, GNAS, GNRH1
4	Inhibition of Matrix Metalloproteinases36	9.5	MMP9, MMP8, MMP2, MMP13, MMP1
5	Activation of Matrix Metalloproteinases38	9.4	MMP1, MMP13, MMP2, MMP8, MMP9, PRSS2
6	Metalloproteases in connective tissue degradation10	9.4	MMP9, MMP8, MMP2, MMP13, MMP1
7	UPA-UPAR Pathway36	9.0	PLAU, MMP9, MMP8, MMP2, MMP13, MMP1
8	Cell adhesion_ECM remodeling41	8.7	PLAU, IGF1, MMP9, MMP2, MMP13, MMP1
9	Cell adhesion ECM remodeling10	8.7	PLAU, IGF1, MMP9, MMP2, MMP13, MMP1
10	Bladder cancer20	8.3	EGF, MMP9, MMP2, MMP1, VEGFA
11	Development Ligand-independent activation of ESR1 and ESR210	8.2	TFF1, EGF, ESR2, ESR1, GNAS, IGF1
12	Development_Ligand-independent activation of ESR1 and ESR241	8.2	TFF1, EGF, ESR2, ESR1, GNAS, IGF1
13	Pancreatic Adenocarcinoma36	7.9	EGF, GNRH1, IGF1, MMP9, MMP8, MMP2
14	Pathways in cancer20	7.4	EGF, GSTP1, MMP9, MMP2, MMP1, VEGFA

Compounds related to ovarian cyst according to GeneDecks:

(show top 50)    (show all 259)

id	Compound	Score	Top Affiliating Genes
1	toremifene32 9 9	11.8	PRL, CYP19A1, ESR2, TFF1
2	17-hydroxyprogesterone32 18	10.4	PRL, MUC16, CGA, CGB5, IGFBP2, GNRH1
3	trilostane32 9 9	11.3	CGB5, CGA, HSD3BP4, ESR1, ESR2
4	h2o232	9.3	MUC16, ESR2, TFF1, ADM, HSD3BP4, MMP8
5	estradiol benzoate32	9.2	PRL, CGA, CGB5, GNRH1, ESR1, ESR2
6	steroidal32	9.2	TFF1, HSD3BP4, CYP19A1, ESR2, ESR1, GNRH1
7	buserelin32 9 9	11.1	CGA, PAEP, IGF1, PRL, CYP19A1, GNRH1
8	progestins32	9.1	TFF1, CYP19A1, ESR2, ESR1, GNRH1, IGFBP2
9	dehydroepiandrosterone sulfate32	9.0	CGA, HSD3BP4, PRL, GNRH1, IGF1, CGB5
10	levonorgestrel32 9 9	11.0	PRL, PAEP, ESR1, ESR2, CYP19A1, MMP1
11	diethylstilbestrol32 9 9	11.0	ESR2, ESR1, GNRH1, CGB5, CGA, CYP19A1
12	letrozole32 42 9 9	11.8	ESR1, ESR2, CYP19A1, CGA, TFF1, IGF1
13	epinephrine32 9 18 9	11.8	PLAU, MMP9, MMP2, MMP1, CGB5, CGA
14	marimastat32 42 9 9	11.8	PLAU, VEGFA, MMP1, MMP9, MMP2, MMP13
15	gnrh32	8.7	IGF1, GNAS, CGB5, IGFBP2, PLAU, EGF
16	leuprolide acetate32	8.6	ESR1, ESR2, CYP19A1, PRL, GNRH1, IGF1
17	androstenedione32 18	9.6	IGFBP2, IGF1, GNRH1, HSD3BP4, ESR2, CYP19A1
18	cetrorelix32 9 9	10.6	IGF1, CGA, CGB5, GNRH1, PLAU, EGF
19	doxycycline32 9 9	10.5	PLAU, GSTP1, MMP9, MMP8, MMP2, MMP13
20	acth32	8.2	GNRH1, IGFBP2, HSD3BP4, CEACAM3, CGB5, IGF1
21	clomiphene citrate32	8.2	PAEP, CGA, CGB5, IGF1, GNRH1, ESR1
22	pge232	8.1	HSD3BP4, CYP19A1, PLAU, EGF, ADM, PAEP
23	estrone32 9 18 9	11.1	PRL, CYP19A1, HSD3BP4, ESR1, ESR2, IGF1
24	methotrexate32 34 42 9 9	11.9	MMP9, CGA, AFP, MMP1, CYP19A1, ESR1
25	lactate32	7.7	CGA, GNRH1, CEACAM3, MMP2, MMP8, MMP9
26	progestin32	7.6	VEGFA, PAEP, CGA, CGB5, IGFBP2, GNRH1
27	hydrocortisone32 9 9	9.5	MMP1, PLAU, EGF, PRL, ADM, IGF1
28	gefitinib32 34 9 9	10.5	CYP19A1, EGF, MMP2, VEGFA, ESR1, MMP9
29	estradiol32 9 18 9	10.5	PAEP, CGA, CGB5, MMP13, HSD3BP4, ESR1
30	dihydrotestosterone32 9 18 9	10.4	EGF, ESR1, CGA, GNRH1, ESR2, IGF1
31	ribonucleic acid32	7.3	MMP9, IGFBP2, IGF1, GNAS, GNRH1, HSD3BP4
32	creatinine32	7.2	MMP1, MMP9, AFP, SPINK1, PLAU, IGF1
33	thymidine32 18	8.1	PLAU, PAEP, AFP, ADM, GNAS, IGFBP2
34	octreotide32 42 9 9	10.1	MMP2, IGF1, GNAS, GNRH1, EGF, PRL
35	mifepristone32 42 9 9	10.1	EGF, PRL, AFP, CYP19A1, ESR2, VEGFA
36	5fluorouracil32	7.0	AFP, EGF, ESR1, GNRH1, CEACAM3, CEACAM7
37	doxorubicin32 34 9 9	9.8	MMP1, AFP, VEGFA, MUC16, CGA, EGF
38	testosterone32 9 18 9	9.5	PAEP, MUC16, CGA, CGB5, MMP1, MMP2
39	paraffin32	6.4	CGA, ADM, AFP, TFF1, PLAU, CGB5
40	tamoxifen32 34 9 9	9.1	VEGFA, PAEP, CGA, CGB5, CEACAM3, IGFBP2
41	dexamethasone32 42 34 9 9	10.0	VEGFA, PRL, MUC16, CGB5, MMP1, AFP
42	serine32	5.8	MMP1, MMP13, CGA, MMP2, MUC16, GSTP1
43	steroid32	5.7	TFF1, PRL, ADM, AFP, HSD3BP4, ESR1
44	genistein32 9 18 9	8.5	MMP2, MMP13, MMP1, CGB5, PAEP, VEGFA
45	cycloheximide32	5.5	CYP19A1, PLAU, EGF, ESR2, ESR1, IGF1
46	actinomycin d32	5.5	GNRH1, ESR1, ESR2, PLAU, EGF, TFF1
47	progesterone32 42 9 18 9	8.8	MMP1, EGF, TFF1, PRL, ADM, AFP
48	retinoic acid32 42 18	6.8	PAEP, LGALS7, CGB5, CEACAM7, AFP, ADM
49	vegf32	4.6	EGF, PLAU, ESR2, ESR1, IGF1, IGFBP2
50	estrogen32	3.6	MMP9, GSTP1, IGFBP2, IGF1, GNRH1, HSD3BP4

Cellular components related to ovarian cyst according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	8.8	VEGFA, MMP1, MMP13, MMP2, MMP8, MMP9
2	extracellular space	GO:005615	5.5	PLAU, EGF, TFF1, PRSS2, ADM, AFP
3	extracellular region	GO:005576	5.2	VEGFA, GNRH1, ESR2, SPINK1, PLAU, EGF

Biological processes related to ovarian cyst according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	female pregnancy	GO:007565	9.5	ADM, PRL, GNRH1, GNAS, IGFBP2
2	collagen catabolic process	GO:030574	9.3	MMP1, MMP13, MMP2, MMP8, MMP9, PRSS2
3	extracellular matrix disassembly	GO:022617	9.3	PRSS2, MMP9, MMP8, MMP2, MMP13, MMP1
4	extracellular matrix organization	GO:030198	9.3	PRSS2, MMP9, MMP8, MMP2, MMP13, MMP1
5	response to estradiol stimulus	GO:032355	9.1	TFF1, CYP19A1, ESR1, IGFBP2, MMP9
6	positive regulation of cerebellar granule cell precursor proliferation	GO:021940	9.0	IGF1, EGF
7	proteolysis	GO:006508	8.7	PRSS2, PLAU, MMP9, MMP8, MMP2, MMP13
8	signal transduction	GO:007165	7.0	ADM, EGF, PLAU, ESR2, ESR1, GNRH1

Molecular functions related to ovarian cyst according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	estrogen response element binding	GO:034056	9.8	ESR1, ESR2
2	estrogen receptor activity	GO:030284	9.5	ESR1, ESR2
3	metalloendopeptidase activity	GO:004222	9.2	MMP9, MMP8, MMP2, MMP13, MMP1
4	hormone activity	GO:005179	9.0	CGA, IGF1, GNRH1, PRL, ADM