MCID: OVR046
MIFTS: 44

Ovarian Cyst malady

Summaries for Ovarian Cyst

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A cyst is a fluid-filled sac. in most cases a cyst on the ovary does no harm and goes away by itself. most women have them sometime during their lives. cysts are rarely cancerous in women under 50. cysts sometimes hurt - but not always. often, a woman finds out about a cyst when she has a pelvic exam. if you're in your childbearing years or past menopause, have no symptoms, and have a fluid-filled cyst, you may choose to monitor the cyst. you may need surgery if you have pain, are past menopause or if the cyst does not go away. birth control pills can help prevent new cysts. a health problem that may involve ovarian cysts is polycystic ovary syndrome (pcos). women with pcos can have high levels of male hormones, irregular or no periods and small ovarian cysts. dept. of health and human services office on women's health

MalaCards: Ovarian Cyst, also known as ovarian cysts, is related to ectopic pregnancy and mccune albright syndrome. An important gene associated with Ovarian Cyst is PRSS2 (protease, serine, 2 (trypsin 2)), and among its related pathways are Glycoprotein hormones and Estrogen biosynthesis. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Related mouse phenotype endocrine/exocrine gland.

Wikipedia:64 An ovarian cyst is any collection of fluid, surrounded by a very thin wall, within an ovary. Any ovarian... more...

Aliases & Classifications for Ovarian Cyst

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

ovarian cyst 8
ovarian cysts 45 34 61


External Ids:

Disease Ontology8 DOID:5119
SNOMED-CT57 198586000
ICD9CM27 620.2

Related Diseases for Ovarian Cyst

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Ovarian Cyst family:

malignant ovarian cyst

Diseases related to Ovarian Cyst via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1ectopic pregnancy30.6PAEP, CGB5, CGA
2mccune albright syndrome30.4GNAS, GNRH1
3ovarian hyperstimulation syndrome30.4CGB5, CYP19A1, CGA, GNRH1
4adenoma30.3IGFBP2, CNC, PAEP, SPINK1, ESR2, CEACAM3
5precocious puberty30.1CGA, GNRH1, CYP19A1, GNAS, CGB5
6thyroiditis29.9CGA
7uterine fibroid29.9GNRH1
8ovarian serous cystadenocarcinoma29.9MUC16
9thyroid cancer29.9GNAS
10corpus luteum cyst29.9CGB5, MUC16
11anovulation29.9CGA, GNRH1, CYP19A1
12adenocarcinoma29.9IGFBP2, CGB5, MUC16, MMP13, PAEP, SPINK1
13neonatal ovarian cyst10.6
14malignant ovarian cyst10.5
15meningocele10.4
16mccune–albright syndrome10.3
17ovarian endometriosis10.2
18congenital adrenal hyperplasia10.2
19polyhydramnios10.2
20ovarian epithelial cancer10.2
21hydronephrosis10.1
22n syndrome10.1
23bladder diverticulum10.1
24lipoid adrenal hyperplasia10.1
25hypogonadotropism10.0GNRH1
26amenorrhea10.0GNRH1
27male infertility10.0GNRH1
28growth hormone deficiency10.0IGFBP2
29sarcoma10.0CGB5
30leiomyosarcoma10.0MUC16
31turner syndrome10.0GNRH1
32meningitis10.0IGFBP2
33gallbladder cancer10.0CEACAM3
34bronchogenic cyst10.0MUC16
35androgen insensitivity syndrome10.0CGA
36hepatitis10.0IGFBP2
37pancreatitis10.0SPINK1, PRSS2
38peritonitis10.0MUC16, MMP8
39aromatase excess syndrome10.0CYP19A1
40chorioamnionitis10.0MMP8
41pancreatic cystadenoma10.0PAEP
42obesity10.0IGFBP2, GNAS
43varicocele10.0GNRH1, CGA
44cystadenocarcinoma10.0CEACAM3, MUC16
45tropical calcific pancreatitis10.0SPINK1
46hepatocellular carcinoma10.0SPINK1, CEACAM3
47premature ovarian failure10.0NOBOX, GNRH1
48germinoma10.0CGB5, CGA
49encephalomyelitis10.0ESR2
50leukemia10.0IGFBP2, PAEP, ESR2

Graphical network of the top 20 diseases related to Ovarian Cyst:



Diseases related to ovarian cyst

Clinical Features for Ovarian Cyst

Drugs & Therapeutics for Ovarian Cyst

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ovarian Cyst

Drug clinical trials:

Search ClinicalTrials for Ovarian Cyst

Search NIH Clinical Center for Ovarian Cyst

Search CenterWatch for Ovarian Cyst

Genetic Tests for Ovarian Cyst

Anatomical Context for Ovarian Cyst

Animal Models for Ovarian Cyst or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ovarian Cyst:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2ESR2, NOBOX

Publications for Ovarian Cyst

Sources:
51PubMed
See all sources

Articles related to Ovarian Cyst:

(show top 50)    (show all 1060)
idTitleAuthorsYear
1
A floating ball: a pathognomonic sign of ovarian cystic teratoma. (23764514)
2013
2
False-positive radioiodine uptake in a functional ovarian cyst in a patient treated with total thyroidectomy for papillary cancer. (24126393)
2013
3
Suspected hemorrhagic ovarian cyst causing fetal anemia measured by the peak systolic velocity in the middle cerebral artery. (23993135)
2013
4
Benign ovarian serous cystadenoma mimicking papillary thyroid carcinoma metastasis on I-131 SPECT/CT. (22474878)
2012
5
Ovarian cyst mimicking ascites on abdominal ultrasonography in a prepubertal female. (24047031)
2012
6
Radioiodine accumulation in a giant ovarian cystadenofibroma detected incidentally by 131-I whole body scans. (23119215)
2012
7
Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle. (21940120)
2011
8
Unilateral ovarian dermoid cyst accompanied by an ipsilateral paratubal cyst in a girl with Proteus Syndrome discovered by laparoscopic surgery. (19833537)
2010
9
Giant ovarian cyst in a woman with congenital adrenal hyperplasia disappeared after adjustment of glucocorticoid therapy. (20467184)
2010
10
Ovarian serous cystadenofibroma with signet ring-stromal cells: report of 2 cases. (20736763)
2010
11
Malignant transformation of ovarian mature cystic teratoma in a postmenopausal woman presented as acute abdomen. (19424710)
2010
12
Gingival metastasis from ovarian mucinous cystadenocarcinoma as an initial manifestation (a rare case report). (19246966)
2008
13
A case of endometriosis of the appendix with adhesion to right ovarian cyst presenting as intussusception of a mucocele of the appendix. (19098675)
2008
14
Precocious pseudopuberty due to autonomous ovarian cysts: a report of ten cases and long-term follow-up. (18477555)
2008
15
Association between milk production and treatment response of ovarian cysts in lactating dairy cows using the Ovsynch protocol. (16650468)
2006
16
Measurement of glycodelin A in fluids of benign ovarian cysts, borderline tumours and malignant ovarian cancer. (16033074)
2005
17
Neonatal ovarian cysts: management with reference to magnetic resonance imaging. (14719514)
2004
18
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. (12855632)
2003
19
Small bowel perforation with minor trauma: a rare complication of an ovarian cystic teratoma. (12435956)
2002
20
Analysis of 20 mature ovarian cystic teratoma cases in postmenopausal women. (11780192)
2001
21
"Daughter cyst" sign: a sonographic finding of ovarian cyst in neonates, infants, and young children. (10749241)
2000
22
Mechanism for the development of ovarian cysts in patients with congenital lipoid adrenal hyperplasia. (10700722)
2000
23
Juvenile fulminant adnexal tuberculosis caused by gastrointestinal tuberculosis immediately after ovarian cystectomy. (11810543)
2000
24
Soluble receptor for urokinase plasminogen activator in both full-length and a cleaved form is present in high concentration in cystic fluid from ovarian cancer. (9699658)
1998
25
Gonadotropin levels in ovarian cyst fluids: a predictor of malignancy? (10079392)
1998
26
Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. (7594774)
1995
27
Relationship between p53 and c-erbB-2 overexpression in tissue sections and cyst fluid cells of patients with ovarian cancer. (7939171)
1994
28
Pulmonary embolism after total hip replacement in a patient who had an ovarian cyst. A case report. (8408162)
1993
29
Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. (1382586)
1992
30
Induction of ovarian follicular cysts in the pregnant rat by human chorionic gonadotropin. (1652291)
1991
31
Spindle cell mural nodules in cystic ovarian mucinous tumors. A clinicopathologic and immunohistochemical study of five cases. (1656803)
1991
32
Sex steroid changes in porcine cystic ovarian disease. (2219200)
1990
33
Ovarian cyst formation: a complication of gonadotropin-releasing hormone agonist therapy. (2521325)
1989
34
Oxidation products of ovarian cyst mucins. Characterisation by density-gradient analysis. (3191512)
1988
35
Ovarian cystadenoma with stromal cell hyperplasia and postmenopausal virilization: a case report. (3169360)
1988
36
Isolation of a novel O-linked, sulfated polysaccharide of high molecular weight from an ovarian cyst glycoprotein having blood group "A" activity. (3593760)
1987
37
Ovarian squamous cell carcinoma derived from a dermoid cyst presenting as vaginal metastasis and the implication of its steroid receptor levels--two case reports. (3943751)
1986
38
Primary ovarian pregnancy in a cystic teratoma. (6472750)
1984
39
Early detection of Wilms' tumor in a child with hemihypertrophy and ovarian cysts. (6283465)
1982
40
Cholesterol crystal pseudoascites: an unusual presentation of ovarian cyst. (7072696)
1982
41
Antenatal sonographic appearance of a fetal ovarian cyst. (7166772)
1982
42
Zollinger-Ellison syndrome due to a gastrin-producing ovarian cystadenocarcinoma. (7296246)
1981
43
Treatment of cystic ovarian disease in dairy cattle. Effects of synthetic gonadotropin-releasing hormone and their relations to pretreatment to serum progesterone levels. (335143)
1977
44
Giant ovarian cyst and full term pregnancy. (321379)
1977
45
Right ovarian vein syndrome with contralateral ovarian cyst. (969052)
1976
46
Entry of nitrous oxide into a giant gas-filled ovarian cyst. A case report. (5856657)
1965
47
Sigmoid volvulus associated with torsion or an ovarian cyst. (14016557)
1963
48
Large ovarian cyst in a newborn infant; successful removal. (13457665)
1957
49
Ovarian cyst in a premature infant. (14798968)
1951
50
Ovarian cyst with twisted omental pedicle. (20995351)
1946

Genetic Variations for Ovarian Cyst

Expression for genes affiliated with Ovarian Cyst

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cyst

Search GEO for disease gene expression data for Ovarian Cyst.

Pathways for genes affiliated with Ovarian Cyst

Sources:
54Reactome, 50PharmGKB, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG
See all sources

Pathways related to Ovarian Cyst according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CGA, GNRH1
2
Hide members
10.2ESR2, CYP19A1
3
Hide members
10.1MMP8, MMP13, PRSS2
4
Cell adhesion ECM remodeling
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10.1MMP13, MMP8, MMP1
5
Hide members
10.1MMP1, MMP8, MMP13
610.1GNAS, CGA, CYP19A1
7
Hide members
10.0PRSS2, MMP13, MMP8, MMP1
8
Development Endothelin-1/EDNRA signaling
Hide members
10.0GNAS, GNRH1, CGA, ESR2
9
Hide members
9.9MMP1, MMP8, MMP13, CGA, GNRH1
10
Hide members
9.8GPR34, PRSS2, CGA, GNRH1, GNAS

Compounds for genes affiliated with Ovarian Cyst

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Ovarian Cyst according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7PAEP
2pge24510.7PAEP
3nafarelin45 60 29 1113.4GNRH1, CYP19A1, CGA
4cycloheximide4510.4IGFBP2, CGB5
5clodronate45 50 1112.4CGA, MMP1, MMP13, MMP8
6tibolone4510.3MMP1, GNRH1, CYP19A1, PAEP
7lutein4510.3CYP19A1, MMP1, CGA, CGB5
8levonorgestrel45 60 29 1113.3CYP19A1, MMP1, PAEP, ESR2
9steroidal4510.3IGFBP2, CYP19A1, ESR2, GNRH1
10bicalutamide45 60 1112.3ESR2, CYP19A1, IGFBP2, GNRH1
11goserelin45 29 1112.2CGA, GNRH1
12(4-aminophenyl)mercuric acetate4510.2MMP13, MMP8
13dexamethasone45 50 29 1113.2MMP13, MUC16, GNRH1, CGB5
14estradiol benzoate4510.2CGB5, CGA, GNRH1, ESR2, CYP19A1
15leuprolide acetate4510.2GNRH1, CGA, ESR2, CGB5, CYP19A1
16diethylstilbestrol45 29 1112.2CYP19A1, CGA, GNRH1, CGB5, ESR2
17buserelin45 29 1112.2CGB5, CYP19A1, PAEP, GNRH1, CGA
18progestins4510.2PAEP, CYP19A1, IGFBP2, ESR2, GNRH1
19trilostane45 1111.2CGA, CGB5, ESR2
20leuprolide45 60 29 1113.2GNRH1, CGB5, CGA
21sialic acid4510.2CEACAM3, PAEP, CGA, GNAS
22dehydroepiandrosterone sulfate4510.1GNRH1, CYP19A1, CGA, CGB5
233beta-hydroxysteroid4510.1CGA, CGB5, CYP19A1, ESR2
24estrone45 29 11 2413.1ESR2, CGB5, GNRH1, IGFBP2, CYP19A1
25clomiphene citrate4510.1ESR2, CYP19A1, GNRH1, CGB5, CGA, PAEP
2617beta-hydroxysteroid4510.1ESR2, CGA, CYP19A1, CGB5
2717-hydroxyprogesterone45 2411.1CYP19A1, GNRH1, MUC16, IGFBP2, CGB5, CGA
28dihydrotestosterone45 29 11 2413.1GNRH1, CGB5, ESR2, IGFBP2, CYP19A1, CGA
29mifepristone45 60 29 1113.0GNRH1, ESR2, PAEP, MMP1, CYP19A1, CGB5
30androstenedione45 2410.9PAEP, CYP19A1, IGFBP2, CGB5, CGA, GNRH1
31gnrh459.9GNAS, IGFBP2, CGB5, CGA, GNRH1, CYP19A1
32genistein45 29 60 2 11 2414.9ESR2, PAEP, MMP1, MMP8, MMP13, CYP19A1
33serine459.9GNAS, SPINK1, CGA, MUC16, MMP1, MMP13
34prostaglandin459.9CGB5, PAEP, MMP1, MMP13, CGA
35prostaglandin f2alpha459.8GNRH1, CGA, CGB5, MMP1
36fibrinogen459.8IGFBP2, CEACAM3, MMP8, MMP13, MUC16, CGB5
37paraffin459.8MUC16, MMP13, CGB5, MMP1, ESR2, CEACAM3
38progestin459.8MMP1, GNRH1, CGA, CGB5, IGFBP2, CYP19A1
39doxorubicin45 50 1111.8CGB5, MUC16, CYP19A1, MMP1, ESR2, CEACAM3
40lactate459.8CGB5, MMP1, GNRH1, CGA, MMP8, CEACAM3
41creatinine459.8CEACAM3, MMP1, CGB5, SPINK1, GNRH1, CGA
42tamoxifen45 50 29 1112.7IGFBP2, ESR2, PAEP, CYP19A1, CGB5, CGA
43ribonucleic acid459.7ESR2, MMP1, PAEP, MMP13, IGFBP2, CGB5
44testosterone45 60 11 2412.6ESR2, CYP19A1, GNRH1, CGA, CGB5, IGFBP2
45retinoic acid45 2410.6MMP13, MMP8, MMP1, PAEP, CYP19A1, IGFBP2
46estradiol45 11 2411.6GNRH1, IGFBP2, MUC16, CYP19A1, MMP13, CGB5
47vegf459.5MUC16, ESR2, PAEP, MMP1, MMP8, MMP13
48steroid459.5GNAS, CYP19A1, IGFBP2, GNRH1, PAEP, ESR2
49acth459.4CGB5, GNRH1, IGFBP2, CEACAM3, GNAS
50progesterone45 60 29 11 2413.2MUC16, GNAS, CEACAM3, ESR2, PAEP, MMP8

GO Terms for genes affiliated with Ovarian Cyst

Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7PRSS2, IGFBP2, MUC16, MMP13, MMP8, GNRH1
2extracellular regionGO:0055768.8ESR2, GNAS, GNRH1, CGA, PRSS2, IGFBP2

Biological processes related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057410.1MMP1, MMP8, MMP13, PRSS2
2extracellular matrix disassemblyGO:02261710.0PRSS2, MMP13, MMP8, MMP1
3extracellular matrix organizationGO:03019810.0MMP1, MMP8, MMP13, PRSS2
4female pregnancyGO:0075659.8IGFBP2, GNRH1, GNAS
5cellular protein metabolic processGO:0442679.7CGA, IGFBP2, MUC16, MMP13, MMP1

Molecular functions related to Ovarian Cyst according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.1MMP1, MMP8, MMP13

Products for genes affiliated with Ovarian Cyst

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Cyst

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet