MCID: OVR048
MIFTS: 29

Ovarian Cystadenoma malady

Categories: Cancer diseases

Aliases & Classifications for Ovarian Cystadenoma

Aliases & Descriptions for Ovarian Cystadenoma:

Name: Ovarian Cystadenoma 12 52 14 69
Simple Cystoma of the Ovary 12
Cystoma Serosum Simplex 12
Simple Cystoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3269
NCIt 47 C4060
SNOMED-CT 64 198297004
UMLS 69 C0346169

Summaries for Ovarian Cystadenoma

MalaCards based summary : Ovarian Cystadenoma, also known as simple cystoma of the ovary, is related to mucinous ovarian cystadenoma and cystadenoma. An important gene associated with Ovarian Cystadenoma is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are Validated targets of C-MYC transcriptional repression and ATF-2 transcription factor network. The drugs Paclitaxel and Albumin-Bound Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 Ovarian cystadenoma is a cystic benign tumor of the ovary. Two types are recognized: serous and... more...

Related Diseases for Ovarian Cystadenoma

Graphical network of the top 20 diseases related to Ovarian Cystadenoma:



Diseases related to Ovarian Cystadenoma

Symptoms & Phenotypes for Ovarian Cystadenoma

GenomeRNAi Phenotypes related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.21 ZNF217
2 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.21 ZNF217
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 10.21 LMNA ZNF217
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.21 ZNF217
5 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.21 LMNA SELE ZNF217
6 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.21 ZNF217
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 ZNF217
8 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.21 ZNF217
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.21 SELE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.21 SELE
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.21 ZNF217
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.21 SELE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 ZNF217
14 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.21 ZNF217
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.21 ZNF217
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 10.21 LMNA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.21 ZNF217
18 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 BRCA1 FH LMNA

MGI Mouse Phenotypes related to Ovarian Cystadenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 BRCA1 CLU LMNA SELE ZMPSTE24
2 homeostasis/metabolism MP:0005376 9.63 BRCA1 CLU FH LMNA SELE ZMPSTE24
3 muscle MP:0005369 9.26 BRCA1 CLU LMNA ZMPSTE24
4 renal/urinary system MP:0005367 9.02 BRCA1 CLU FH LMNA ZMPSTE24

Drugs & Therapeutics for Ovarian Cystadenoma

Drugs for Ovarian Cystadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved 33069-62-4 36314
2 Albumin-Bound Paclitaxel

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
2 Ovarian Clear Cell Adenocarcinoma Review Completed NCT02129036

Search NIH Clinical Center for Ovarian Cystadenoma

Genetic Tests for Ovarian Cystadenoma

Anatomical Context for Ovarian Cystadenoma

MalaCards organs/tissues related to Ovarian Cystadenoma:

39
Ovary, Bone

Publications for Ovarian Cystadenoma

Articles related to Ovarian Cystadenoma:

(show all 34)
id Title Authors Year
1
Ruptured benign serous ovarian cystadenoma mimicking ovarian malignancy with peritoneal carcinomatosis. ( 27421673 )
2016
2
Ovarian Cystadenoma in a Trafficked Patient. ( 27244785 )
2016
3
An unexpected death due to massive ascites and a giant mucinous ovarian cystadenoma. ( 27890095 )
2016
4
Presacral epidermoid cyst in an elderly female, mistaken for ovarian cystadenoma. ( 25404834 )
2014
5
Bilateral ovarian cystadenoma in a geriatric African elephant (Loxodonta africana). ( 25000708 )
2014
6
Perioperative management for the removal of a massive ovarian cystadenoma. ( 25612086 )
2013
7
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. ( 21792894 )
2012
8
Abnormal A^A^A^I uptake in a benign serous ovarian cystadenoma mimicking bladder physiological uptake. ( 22310273 )
2012
9
Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumarate hydratase. ( 24396716 )
2011
10
A woman with salt-wasting congenital adrenal hyperplasia presenting with a mucinous ovarian cystadenoma during pregnancy. ( 21921381 )
2011
11
Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. ( 20819672 )
2010
12
Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. ( 17179812 )
2007
13
Rapidly growing bilateral ovarian cystadenoma in a 6-year-old girl: case report and literature review. ( 16472727 )
2006
14
Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. ( 15131356 )
2004
15
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. ( 12855632 )
2003
16
Tuberculous peritonitis with sonographic features of an ovarian cystadenoma. ( 14510274 )
2003
17
Massive ovarian cystadenoma detected solely on the blood-pool phase of a bone scan. ( 12045453 )
2002
18
Periampullary carcinoma with bilateral ovarian cystadenoma in pregnancy. ( 9563228 )
1998
19
Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. ( 9441775 )
1997
20
Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. ( 7508878 )
1994
21
Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. ( 1382586 )
1992
22
Clinicostatistical study of low potential malignancy ovarian cystadenoma (borderline cases). ( 1867577 )
1991
23
"Pseudoascites" secondary to an amylase-producing serous ovarian cystadenoma. A case study. ( 2479672 )
1989
24
Ovarian cystadenoma with stromal cell hyperplasia and postmenopausal virilization: a case report. ( 3169360 )
1988
25
Borderline ovarian cystadenoma. Spontaneous rupture and reaccumulation documented by ultrasound. ( 3286886 )
1988
26
A plasminogen activator from benign ovarian cystadenoma: partial purification and characterization. ( 3961743 )
1986
27
Cystic parametrial fibroids mimicking ovarian cystadenoma. ( 6726872 )
1984
28
Conservative management of the Zollinger-Ellison syndrome. Ectopic gastrin production by an ovarian cystadenoma. ( 7365959 )
1980
29
A benign serous ovarian cystadenoma studied by chromosome and quantitative DNA analysis. ( 274883 )
1977
30
Virilization in pregnancy associated with an ovarian cystadenoma. ( 4416869 )
1974
31
Acute abdominal symptoms due to torsion of an ovarian cystadenoma in a centenarian. ( 5053461 )
1972
32
Chromosomal aberrations in an ovarian cystadenoma. ( 4185609 )
1969
33
Free and conjugated estrogens of an ovarian cystadenoma and granulosa cell tumor. ( 4284085 )
1965
34
PSEUDOMYXOMA PERITONAEI SECONDARY TO OVARIAN CYSTADENOMA. ( 20317773 )
1930

Variations for Ovarian Cystadenoma

Expression for Ovarian Cystadenoma

Search GEO for disease gene expression data for Ovarian Cystadenoma.

Pathways for Ovarian Cystadenoma

Pathways related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.74 BRCA1 CLU
2 10.36 BRCA1 SELE

GO Terms for Ovarian Cystadenoma

Biological processes related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.33 BRCA1 CLU LMNA
2 nuclear envelope organization GO:0006998 8.96 LMNA ZMPSTE24
3 negative regulation of release of cytochrome c from mitochondria GO:0090201 8.62 CLU LMNA

Sources for Ovarian Cystadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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