MCID: OVR048
MIFTS: 41

Ovarian Cystadenoma malady

Cancer diseases category

Summaries for Ovarian Cystadenoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Ovarian cystadenoma is a cystic benign tumor of the ovary. Two types are recognized: serous and mucinous. more...

MalaCards: Ovarian Cystadenoma, also known as simple cystoma of the ovary, is related to cystadenoma and ovarian cancer. An important gene associated with Ovarian Cystadenoma is SELE (selectin E), and among its related pathways are Development VEGF signaling and activation and ATF-2 transcription factor network. The compounds 8-chloro-camp and pd153035 have been mentioned in the context of this disorder. Affiliated tissues include ovary and bone, and related mouse phenotypes are immune system and integument.

Aliases & Classifications for Ovarian Cystadenoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian cystadenoma 9 11 46 63
simple cystoma of the ovary 9
simple cystoma of ovary 9
cystoma serosum simplex 9


External Ids:

Disease Ontology9 DOID:3269
SNOMED-CT59 198297004
NCIt41 C4060

Related Diseases for Ovarian Cystadenoma

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18GeneCards, 19GeneDecks
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Diseases related to Ovarian Cystadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenoma31.3CLU, BRCA1, AREG
2ovarian cancer30.1TGFA, CLDN3, CLDN4, CLU, BRCA1, MUC16
3mucinous ovarian cystadenoma10.4
4leukostasis10.1SELE
5congenital adrenal hyperplasia10.1
6tuberculous peritonitis10.1
7zollinger-ellison syndrome10.1
8leiomyomatosis10.1
9peritonitis10.1
10struma ovarii10.1
11myxedema10.1LGR6
12cystadenocarcinoma10.1MUC16, AREG
13malignant mesothelioma10.0AREG, MUC16
14anaplastic large cell lymphoma10.0CLU, MUC16
15cervical cancer10.0CLU, MUC16, AREG
16deficiency anemia10.0AREG, MUC16, BRCA1
17bladder carcinoma10.0AREG, CLU, TGFA
18skin disease10.0TGFA, SELE, AREG
19breast cancer10.0AREG, BRCA1, TGFA
20sickle cell disease10.0BRCA1, SELE
21papillary carcinoma10.0CLDN3, CLDN4, MUC16
22benign mesothelioma10.0AREG, MUC16, CLDN3
23psoriasis10.0TGFA, SELE, AREG
24acanthosis nigricans10.0TGFA, LMNA
25pancreatic cancer10.0AREG, BRCA1, CLDN4, TGFA
26colorectal cancer10.0CLU, BRCA1, MUC16, AREG
27werner syndrome10.0LMNA, BRCA1
28gastric adenocarcinoma10.0TGFA, CLDN3, CLDN4, MUC16
29coronary artery disease10.0LMNA, CLU, SELE
30stomach cancer10.0TGFA, CLDN3, CLDN4, AREG
31endometrial carcinoma10.0TGFA, CLDN3, BRCA1, MUC16
32colon cancer10.0TGFA, SELE, CLU, BRCA1, AREG
33hypertrophy of breast10.0LMNA, BRCA1, CLU
34lung cancer9.9TGFA, LMNA, MUC16, AREG
35adenoma9.9AREG, BRCA1, CLDN4, CLDN3, TGFA
36retinoblastoma9.9LMNA, BRCA1, CLU
37tongue squamous cell carcinoma9.9TGFA, CLDN3, CLDN4, CLU, MUC16, AREG
38adenocarcinoma9.9TGFA, CLDN3, CLDN4, CLU, BRCA1, MUC16
39prostate cancer9.9TGFA, CLDN3, CLDN4, CLU, BRCA1, MUC16

Graphical network of the top 20 diseases related to Ovarian Cystadenoma:



Diseases related to ovarian cystadenoma

Symptoms for Ovarian Cystadenoma

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Drugs & Therapeutics for Ovarian Cystadenoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ovarian Cystadenoma

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Anatomical Context for Ovarian Cystadenoma

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34MalaCards
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MalaCards organs/tissues related to Ovarian Cystadenoma:

34
Ovary, Bone

Animal Models for Ovarian Cystadenoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Cystadenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4AREG, LMNA, BRCA1, CLU, SELE, TGFA
2MP:00107718.4TGFA, SELE, BRCA1, LMNA, AREG
3MP:00053858.3AREG, LMNA, BRCA1, CLU, SELE, TGFA

Publications for Ovarian Cystadenoma

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53PubMed
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Articles related to Ovarian Cystadenoma:

(show all 28)
idTitleAuthorsYear
1
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. (21792894)
2012
2
Abnormal A^A^A^I uptake in a benign serous ovarian cystadenoma mimicking bladder physiological uptake. (22310273)
2012
3
A woman with salt-wasting congenital adrenal hyperplasia presenting with a mucinous ovarian cystadenoma during pregnancy. (21921381)
2011
4
Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumarate hydratase. (24396716)
2011
5
Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. (20819672)
2010
6
Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. (17179812)
2007
7
Rapidly growing bilateral ovarian cystadenoma in a 6-year-old girl: case report and literature review. (16472727)
2006
8
Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. (15131356)
2004
9
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. (12855632)
2003
10
Tuberculous peritonitis with sonographic features of an ovarian cystadenoma. (14510274)
2003
11
Massive ovarian cystadenoma detected solely on the blood-pool phase of a bone scan. (12045453)
2002
12
Periampullary carcinoma with bilateral ovarian cystadenoma in pregnancy. (9563228)
1998
13
Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. (9441775)
1997
14
Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. (7508878)
1994
15
Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. (1382586)
1992
16
Clinicostatistical study of low potential malignancy ovarian cystadenoma (borderline cases). (1867577)
1991
17
"Pseudoascites" secondary to an amylase-producing serous ovarian cystadenoma. A case study. (2479672)
1989
18
Borderline ovarian cystadenoma. Spontaneous rupture and reaccumulation documented by ultrasound. (3286886)
1988
19
Ovarian cystadenoma with stromal cell hyperplasia and postmenopausal virilization: a case report. (3169360)
1988
20
A plasminogen activator from benign ovarian cystadenoma: partial purification and characterization. (3961743)
1986
21
Cystic parametrial fibroids mimicking ovarian cystadenoma. (6726872)
1984
22
Conservative management of the Zollinger-Ellison syndrome. Ectopic gastrin production by an ovarian cystadenoma. (7365959)
1980
23
A benign serous ovarian cystadenoma studied by chromosome and quantitative DNA analysis. (274883)
1977
24
Virilization in pregnancy associated with an ovarian cystadenoma. (4416869)
1974
25
Acute abdominal symptoms due to torsion of an ovarian cystadenoma in a centenarian. (5053461)
1972
26
Chromosomal aberrations in an ovarian cystadenoma. (4185609)
1969
27
Free and conjugated estrogens of an ovarian cystadenoma and granulosa cell tumor. (4284085)
1965
28
PSEUDOMYXOMA PERITONAEI SECONDARY TO OVARIAN CYSTADENOMA. (20317773)
1930

Variations for Ovarian Cystadenoma

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Expression for genes affiliated with Ovarian Cystadenoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cystadenoma

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Pathways for genes affiliated with Ovarian Cystadenoma

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.9BRCA1, SELE
29.9BRCA1, SELE
39.0CLDN4, CLDN3, SELE

Compounds for genes affiliated with Ovarian Cystadenoma

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
18-chloro-camp4610.0TGFA, AREG
2pd153035469.9AREG, TGFA
3sialic acid469.9SELE, CLU, MUC16
4cyclophosphamide46 52 1211.9MUC16, BRCA1, SELE
5sn 3846 6210.8TGFA, AREG
6topotecan46 1210.8TGFA, BRCA1, MUC16
7methotrexate52 46 1211.7BRCA1, SELE, TGFA
85fluorouracil469.7TGFA, SELE, BRCA1
9mitomycin c469.7AREG, BRCA1, TGFA
10dihydrotestosterone46 30 25 1212.7TGFA, CLU, AREG
11ochratoxin a46 6210.6CLDN4, CLDN3
12matrigel469.6CLU, SELE, TGFA
13calcitriol46 62 25 1212.6AREG, CLU, TGFA
14cetuximab46 52 1211.6TGFA, AREG
15folate469.6BRCA1, CLU, SELE, TGFA
16n acetylcysteine469.6AREG, CLU, SELE
17etoposide46 52 62 1212.6TGFA, SELE, CLU, BRCA1
18tamoxifen46 52 30 1212.6TGFA, SELE, CLU, BRCA1
19lactate469.5TGFA, SELE, CLU, MUC16
20gnrh469.5TGFA, CLU, LGR6
21cisplatin46 52 62 1212.5AREG, MUC16, BRCA1, CLU
22paclitaxel46 52 1211.5MUC16, BRCA1, CLU, TGFA
23paraffin469.5TGFA, CLU, BRCA1, MUC16
244-hydroxytamoxifen469.5TGFA, CLU, BRCA1, AREG
25polysaccharide469.5TGFA, SELE, CLU, AREG
26epinephrine46 25 1211.5TGFA, SELE, AREG
27actinomycin d469.5AREG, CLU, SELE, TGFA
28enterotoxin469.4CLDN4, CLDN3
29creatinine469.4MUC16, LMNA, SELE, TGFA
30h2o2469.4TGFA, CLU, BRCA1, MUC16
31thymidine46 2510.4TGFA, CLU, BRCA1, AREG
32norepinephrine46 25 1211.3AREG, SELE, TGFA
33dexamethasone46 52 30 1212.3CLDN4, CLU, MUC16, AREG
34fibrinogen469.3SELE, CLU, MUC16
35oligonucleotide469.3AREG, BRCA1, CLU, TGFA
36doxorubicin46 52 1211.3TGFA, SELE, CLU, BRCA1, MUC16
37heparin46 30 25 1212.2TGFA, SELE, CLU, BRCA1, AREG
38cycloheximide469.2AREG, BRCA1, CLU, SELE, TGFA
39estradiol46 25 1211.1TGFA, CLU, BRCA1, MUC16, AREG
40retinoic acid46 2510.1TGFA, CLU, BRCA1, LMNA, AREG
41alanine469.0LMNA, BRCA1, SELE, TGFA
42progesterone46 30 62 25 1212.7TGFA, CLDN4, CLU, BRCA1, MUC16, AREG
43cholesterol46 30 25 1211.7LGR6, LMNA, CLU, CLDN3, SELE
44steroid468.6TGFA, CLU, BRCA1, MUC16, LGR6, AREG
45testosterone46 62 25 1211.3TGFA, SELE, CLU, BRCA1, MUC16, LGR6
46calcium46 52 25 1211.3CLDN3, CLDN4, CLU, BRCA1, LMNA, AREG
47estrogen468.2TGFA, CLDN4, CLU, BRCA1, MUC16, LGR6
48tyrosine468.2TGFA, CLDN4, CLU, BRCA1, MUC16, LGR6
49vegf468.0TGFA, SELE, CLDN3, CLU, BRCA1, MUC16
50serine467.6AREG, TGFA, SELE, CLDN4, CLU, BRCA1

GO Terms for genes affiliated with Ovarian Cystadenoma

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17Gene Ontology
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Cellular components related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.1LMNA, CLU, SELE, TGFA
2extracellular spaceGO:0056157.7CKLF, TGFA, SELE, CLU, MUC16, CMTM5

Biological processes related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:0163389.3CLDN4, CLDN3

Molecular functions related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.0LMNA, CLDN4, CLDN3
2transmembrane signaling receptor activityGO:0048888.2LGR6, CLDN4, CLDN3, SELE

Products for genes affiliated with Ovarian Cystadenoma

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Sources for Ovarian Cystadenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet