MCID: OVR048
MIFTS: 41

Ovarian Cystadenoma malady

Summaries for Ovarian Cystadenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ovarian cystadenoma is a cystic benign tumor of the ovary. Two types are recognized: serous and mucinous. more...

MalaCards: Ovarian Cystadenoma, also known as simple cystoma of the ovary, is related to cystadenoma and ovarian cancer. An important gene associated with Ovarian Cystadenoma is FH (fumarate hydratase), and among its related pathways is Cell adhesion molecules (CAMs). The compounds cycloheximide and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and bone, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Ovarian Cystadenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

ovarian cystadenoma 8 10 44 60
simple cystoma of the ovary 8
simple cystoma of ovary 8
cystoma serosum simplex 8


External Ids:

Disease Ontology8 DOID:3269
SNOMED-CT56 198297004
NCIt39 C4060

Related Diseases for Ovarian Cystadenoma

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Cystadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenoma31.1BRCA1, AREG, CLU
2ovarian cancer30.2BRCA1, AREG, MUC16, CLDN3, CLDN4, CLU
3peritonitis30.0MUC16
4mucinous ovarian cystadenoma10.4
5tuberculous peritonitis10.0
6congenital adrenal hyperplasia10.0
7benign struma ovarii10.0
8zollinger-ellison syndrome10.0
9protein c deficiency10.0
10leiomyomatosis10.0
11struma ovarii10.0
12fumarate hydratase deficiency10.0
13endometriosis10.0MUC16
14kidney cancer10.0FH
15wilms tumor10.0AREG
16leiomyoma10.0FH
17leiomyosarcoma10.0FH, MUC16
18synovitis10.0SELE
19colon adenocarcinoma10.0AREG, TGFA
20hemangioma10.0CLU
21familial colorectal cancer10.0FH, BRCA1
22myxedema10.0LGR6
23peritoneal carcinoma10.0BRCA1
24deficiency anemia10.0BRCA1, AREG, MUC16
25leukemia10.0AREG, BRCA1
26myopathy10.0LMNA
27benign mesothelioma10.0AREG, MUC16, CLDN3
28papillary carcinoma10.0CLDN4, CLDN3, MUC16
29hypogonadism10.0LGR6
30infertility10.0CLU, LGR6
31familial adenomatous polyposis10.0CLU, BRCA1
32cervical cancer10.0CLU, MUC16, AREG
33breast cancer10.0TGFA, AREG, BRCA1
34colorectal cancer10.0BRCA1, AREG, MUC16, CLU
35pancreatic cancer10.0TGFA, CLDN4, AREG, BRCA1
36skin disease10.0AREG, SELE, TGFA
37obesity10.0SELE, LMNA
38gastric adenocarcinoma10.0TGFA, CLDN4, CLDN3, MUC16
39bladder carcinoma10.0BRCA1, AREG, CLU, TGFA
40endometrial carcinoma10.0BRCA1, MUC16, CLDN3, TGFA
41stomach cancer10.0TGFA, CLDN4, CLDN3, AREG
42adenoma10.0BRCA1, AREG, CLDN3, CLDN4, TGFA
43acanthosis nigricans10.0LMNA, TGFA
44squamous cell carcinoma10.0AREG, MUC16, CLDN3, CLDN4, CLU, TGFA
45adenocarcinoma10.0BRCA1, AREG, MUC16, CLDN3, CLDN4, CLU
46colon cancer10.0TGFA, SELE, LMNA, CLDN3, AREG
47lung cancer10.0AREG, MUC16, AHRR, LMNA, TGFA
48prostate cancer10.0BRCA1, FH, AREG, MUC16, CLDN3, CLDN4

Graphical network of the top 20 diseases related to Ovarian Cystadenoma:



Diseases related to ovarian cystadenoma

Clinical Features for Ovarian Cystadenoma

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Drugs & Therapeutics for Ovarian Cystadenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ovarian Cystadenoma

Drug clinical trials:

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Genetic Tests for Ovarian Cystadenoma

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Anatomical Context for Ovarian Cystadenoma

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32MalaCards
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MalaCards organs/tissues related to Ovarian Cystadenoma:

32
Ovary, Liver, Bone, Thyroid, Smooth muscle, Colon

Animal Models for Ovarian Cystadenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Cystadenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0LMNA, CLU, CLDN4, FH, BRCA1

Publications for Ovarian Cystadenoma

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50PubMed
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Articles related to Ovarian Cystadenoma:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Acute abdominal distension in early pregnancy from torted ovarian serous cystadenoma. (24359062)
2014
2
Coexistence of benign ovarian serous cystadenoma and tuberculosis in a young woman. (24005462)
2013
3
Successful Vaginal Delivery despite a Huge Ovarian Mucinous Cystadenoma Complicating Pregnancy: A Case Report. (24293789)
2013
4
Ovarian mucinous cystadenoma coexisting with benign Brenner tumor: MR imaging findings. (22476372)
2013
5
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. (21792894)
2012
6
Ovarian fibroma with serous cystadenoma-an unusual combination: a case report. (22844626)
2012
7
Metastatic renal cell carcinoma in an ovarian benign mixed mucinous cystadenoma and brenner tumour: a case report. (23227402)
2012
8
Abnormal A^A^A^I uptake in a benign serous ovarian cystadenoma mimicking bladder physiological uptake. (22310273)
2012
9
A woman with salt-wasting congenital adrenal hyperplasia presenting with a mucinous ovarian cystadenoma during pregnancy. (21921381)
2011
10
Ovarian mucinous cystadenoma in a gray brocket deer (Mazama gouazoupira). (21908297)
2011
11
A rare case of the coexistence of ovarian clear cell carcinoma, mucinous cystadenoma, and endometriosis in the same ovary. (22335035)
2011
12
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. (20736765)
2010
13
Does intraoperative spillage of benign ovarian mucinous cystadenoma increase its recurrence rate? (20022314)
2010
14
Ovarian mucinous cystadenoma of borderline malignancy in a premenarchal girl. (19896401)
2010
15
Mucinous cystadenoma arising 3 years after ovarian-sparing surgery for mature teratoma in a child. (20713202)
2010
16
Ovarian clear cell carcinoma arising in a mucinous cystadenoma. (19851211)
2009
17
The co-location of an ovarian clear cell carcinoma and mucinous cystadenoma. (19291542)
2009
18
Complex serous cystadenoma with ovarian stroma of the fallopian tube ampulla presenting surgically. (19697223)
2009
19
A huge ovarian mucinous cystadenoma in a 14-year-old premenarchal girl: review on ovarian mucinous tumor in premenarchal girls. (18312801)
2008
20
Ovarian mucinous cystadenoma with smooth muscle proliferation in a cynomolgus monkey (Macaca fascicularis). (18487498)
2008
21
Osseous metaplasia in ovarian tumours: a case with serous cystadenoma. (17513522)
2007
22
Clinical significance of N-acetyl-L-aspartate resonance in ovarian mucinous cystadenoma. (16445669)
2006
23
Massive ovarian edema associated with ovarian serous cystadenoma: a case report and review of the literature. (16515615)
2006
24
Rapidly growing bilateral ovarian cystadenoma in a 6-year-old girl: case report and literature review. (16472727)
2006
25
Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma. (16639410)
2006
26
Halving of body weight: a case of an ovarian mucinous cystadenoma. (16550979)
2006
27
Ovarian mucinous cystadenoma with extended calcification in an 11-year-old girl: case report and review of the literature. (17089585)
2006
28
Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. (15797026)
2005
29
Ureteral endometriosis and ovarian mucinous cystadenoma presenting with acute pyonephrosis. (15868895)
2005
30
Ovarian serous cystadenoma with mural nodules of genital rhabdomyoma. (15892006)
2005
31
Intra-abdominal ovarian-type mucinous cystadenoma associated with fallopian tube-like structure and aberrant epididymal tissue in a male patient. (16112012)
2005
32
Ovarian serous cystadenoma with associated genital rhabdomyoma. (16260279)
2005
33
Molecular genetic analysis of ovarian serous cystadenomas. (15077125)
2004
34
Sarcoma-like mural nodule in an ovarian mucinous cystadenoma: a case report. (16295477)
2004
35
Ovarian mucinous cystadenoma in a female with Turner syndrome. (15448783)
2004
36
Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. (15131356)
2004
37
Massive ovarian mucinous cystadenoma in a 14-year-old girl. (14675997)
2004
38
Periampullary carcinoma with bilateral ovarian cystadenoma in pregnancy. (9563228)
1998
39
Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. (9441775)
1997
40
Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. (8786207)
1996
41
Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. (7508878)
1994
42
Unique combination of an ovarian gonadoblastoma, dysgerminoma, and mucinous cystadenoma in a patient with Turner's syndrome: a cytogenetic and molecular analysis. (7928059)
1994
43
Clinicostatistical study of low potential malignancy ovarian cystadenoma (borderline cases). (1867577)
1991
44
Borderline ovarian cystadenoma. Spontaneous rupture and reaccumulation documented by ultrasound. (3286886)
1988
45
Ovarian cystadenoma with stromal cell hyperplasia and postmenopausal virilization: a case report. (3169360)
1988
46
Zollinger-Ellison syndrome due to a gastrin secreting ovarian mucinous cystadenoma. Case report. (4027214)
1985
47
Conservative management of the Zollinger-Ellison syndrome. Ectopic gastrin production by an ovarian cystadenoma. (7365959)
1980
48
A benign serous ovarian cystadenoma studied by chromosome and quantitative DNA analysis. (274883)
1977
49
Virilization in pregnancy associated with an ovarian cystadenoma. (4416869)
1974
50
Free and conjugated estrogens of an ovarian cystadenoma and granulosa cell tumor. (4284085)
1965

Genetic Variations for Ovarian Cystadenoma

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Expression for genes affiliated with Ovarian Cystadenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Cystadenoma

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Pathways for genes affiliated with Ovarian Cystadenoma

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29KEGG
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Pathways related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SELE, CLDN4, CLDN3

Compounds for genes affiliated with Ovarian Cystadenoma

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6BRCA1
2sialic acid4410.4SELE
3estrogen4410.3LGR6
4estradiol44 11 2412.2MUC16, CLU
58-chloro-camp449.9TGFA, AREG
6ochratoxin a44 5910.8CLDN3, CLDN4
7topotecan44 1110.8TGFA, MUC16, BRCA1
8pd153035449.6TGFA, AREG
9mitomycin c449.6TGFA, AREG, BRCA1
10folate449.6TGFA, SELE, CLU, BRCA1
11etoposide44 49 59 1112.5BRCA1, CLU, SELE, TGFA
12tamoxifen44 49 28 1112.5BRCA1, CLU, SELE, TGFA
13cyclophosphamide44 49 1111.5SELE, MUC16, BRCA1
144-hydroxytamoxifen449.5BRCA1, AREG, CLU, TGFA
15dihydrotestosterone44 28 11 2412.4TGFA, CLU, AREG
16proline449.4BRCA1, FH, CLU, TGFA
17paclitaxel44 49 1111.4BRCA1, MUC16, CLU, TGFA
18polysaccharide449.4TGFA, SELE, CLU, AREG
19paraffin449.3BRCA1, MUC16, CLU, TGFA
20actinomycin d449.3TGFA, SELE, CLU, AREG
21cisplatin44 49 59 1112.3BRCA1, AREG, MUC16, CLU
22doxorubicin44 49 1111.2BRCA1, MUC16, CLU, SELE, TGFA
23lactate449.2FH, MUC16, CLU, SELE, TGFA
24creatinine449.2FH, MUC16, LMNA, SELE, TGFA
25heparin44 28 11 2412.1BRCA1, AREG, CLU, SELE, TGFA
26cholesterol44 28 11 2411.9CLDN3, CLU, LMNA, LGR6, SELE
27thymidine44 249.8BRCA1, AREG, CLU, TGFA
28retinoic acid44 249.8TGFA, LMNA, CLU, AREG, BRCA1
29progesterone44 59 28 11 2412.7BRCA1, AREG, MUC16, CLDN4, CLU, TGFA
30steroid448.6BRCA1, AREG, MUC16, CLU, LGR6, TGFA
31testosterone44 59 11 2411.3TGFA, BRCA1, AREG, MUC16, CLU, LGR6
32vegf448.3BRCA1, AREG, MUC16, CLDN3, CLU, SELE
33tyrosine448.0BRCA1, FH, AREG, MUC16, CLDN4, CLU
34serine447.7BRCA1, AREG, MUC16, CLDN4, CLU, LMNA

GO Terms for genes affiliated with Ovarian Cystadenoma

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16Gene Ontology
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Cellular components related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.2TGFA, SELE, LMNA, CLU
2extracellular spaceGO:0056157.4TGFA, CKLF, MUC16, CLU, CMTM5, SELE

Biological processes related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:0163389.6CLDN4, CLDN3

Molecular functions related to Ovarian Cystadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.3LMNA, CLDN4, CLDN3
2transmembrane signaling receptor activityGO:0048888.5SELE, LGR6, CLDN4, CLDN3

Products for genes affiliated with Ovarian Cystadenoma

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Sources for Ovarian Cystadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet