Ovarian Cystadenoma malady

MalaCards: Ovarian Cystadenoma, also known as simple cystoma of the ovary (disorder), is related to mucinous ovarian cystadenoma and ovarian cancer. An important gene associated with Ovarian Cystadenoma is MUC16 (mucin 16, cell surface associated), and among its related pathways is Cell adhesion molecules (CAMs). The compounds 8-chloro-camp and ochratoxin a have been mentioned in the context of this disorder. Affiliated tissues include ovary.

Aliases & Descriptions:

ovarian cystadenoma 6 8 32 43 simple cystoma of the ovary (disorder) 6 simple cystoma of ovary 6

cystoma serosum simplex 6 cystadenoma 43

Diseases related to ovarian cystadenoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 97)

id	Related Disease	Score	Top Affiliating Genes
1	mucinous ovarian cystadenoma	32.1	MUC16, FH
2	ovarian cancer	30.6	MUC16, BRCA1
3	pancreatitis	27.9	CLDN3, TGFA, FH, AREG, MUC16, BRCA1
4	cystadenoma	27.9	AREG, FH, TGFA, CLDN3, MUC16, LGR6
5	peritonitis	25.6	TGFA, MUC16, CLDN3, CLDN4, BRCA1, SELE
6	adenoma	25.3	TGFA, MUC16, BRCA1, CLDN3, CLU, AREG
7	endometriosis	24.9	BRCA1, TGFA, AHRR, MUC16, CLDN3, CLDN4
8	ovarian carcinoma	24.4	LGR6, CLDN4, BRCA1, AREG, TGFA, MUC16
9	adenocarcinoma	24.2	AHRR, MUC16, TGFA, AREG, CLDN4, CLU
10	carcinoma	23.6	MUC16, SELE, BRCA1, LMNA, CMTM5, CLDN4
11	hepatitis	21.9	CLDN4, LMNA, SELE, CKLF, MUC16, AREG
12	papillary serous carcinoma of the peritoneum	13.3	MUC16, BRCA1
13	fallopian tube carcinoma	13.2	BRCA1, MUC16
14	nonpapillary renal cell carcinoma	13.2	CLU, TGFA
15	malignant peritoneal mesothelioma	13.1	MUC16, CLDN3
16	restrictive dermopathy	13.0	TGFA, LMNA
17	uterine carcinosarcoma	13.0	CLDN4, CLDN3, MUC16
18	myxedema	12.9	LGR6, MUC16
19	nonencapsulated sclerosing carcinoma	12.9	CLDN4, CLDN3, MUC16
20	benign mesothelioma	12.9	AREG, MUC16, CLDN3
21	inclusion body myositis	12.8	MUC16, CKLF, SELE
22	mucoepidermoid carcinoma	12.7	AREG, TGFA, CLDN3
23	wilms tumor	12.7	AREG, MUC16, BRCA1, TGFA
24	urinary bladder cancer	12.7	TGFA, AREG, BRCA1, CLU
25	carcinoid tumors	12.6	CLDN4, CLDN3, TGFA
26	gastric adenocarcinoma	12.6	MUC16, CLDN3, CLDN4, TGFA
27	lung occult squamous cell carcinoma	12.6	TGFA, AREG, CLDN3, CLDN4
28	kidney cancer	12.6	FH, SELE, CLU
29	breast cancer	12.6	TGFA, AREG, BRCA1
30	hemangioma	12.5	TGFA, CLU, SELE
31	prostate colloid adenocarcinoma	12.5	TGFA, AREG, CLDN3, CLDN4
32	leiomyosarcoma	12.5	FH, MUC16, BRCA1, TGFA
33	pancreatic carcinoma	12.4	TGFA, CLU, CLDN4, SELE
34	leiomyoma	12.4	FH, MUC16, BRCA1, TGFA
35	inflammatory bowel disease	12.3	CLDN4, SELE, BRCA1, TGFA, AREG
36	basal cell carcinoma	12.3	TGFA, AREG, SELE, LMNA
37	endometrial carcinoma	12.3	MUC16, TGFA, CLDN3, BRCA1, CLU
38	lung adenocarcinoma	12.2	CLDN4, MUC16, AREG, TGFA, CLU, SELE
39	polyposis	12.1	SELE, TGFA, CLU, LMNA, BRCA1
40	myopathy	12.1	MUC16, CKLF, LMNA, SELE, CLU
41	laryngeal cancer	12.1	TGFA, BRCA1, AHRR
42	endometrial cancer	12.1	BRCA1, CLDN4, TGFA, CLDN3, MUC16, AREG
43	squamous cell carcinoma	12.0	CLDN3, CLDN4, MUC16, CLU, AREG, TGFA
44	bartter disease	12.0	BRCA1, CLDN3, TGFA, AREG
45	colon adenocarcinoma	12.0	BRCA1, AREG, TGFA, MUC16, LMNA, CLU
46	bladder carcinoma	12.0	TGFA, FH, CLU, CLDN4, SELE, AREG
47	anemia	11.9	BRCA1, SELE, AREG, CLU, MUC16, LMNA
48	epithelial ovarian cancer	11.9	TGFA, MUC16, CLDN3, CLU, CMTM5, BRCA1
49	boomerang dysplasia	11.8	CLDN4, LMNA, BRCA1, CLU, CLDN3, TGFA
50	pulmonary disease	11.7	SELE, BRCA1, MUC16, AREG, AHRR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ovarian cystadenoma:

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Articles related to ovarian cystadenoma:

id	Title	Authors	Year	Affiliating Genes
1	Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. (20819672)	Cai M.Y.... Weng J.P.	2010	LMNA
2	Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. (15131356)	Menkiszak J.... LubiA8ski J.	2004	BRCA1
3	Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. (12855632)	Rangel L.B.... Morin P.J.	2003	CLDN4, CLDN3
4	Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. (9441775)	Luo M.P.... Dubeau L.	1997	BRCA1, LGR6
5	Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. (7508878)	Ye C.... Takagi H.	1994	MUC16
6	Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. (1382586)	Yuen C.T.... Feizi T.	1992	SELE

Genes related to ovarian cystadenoma according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	MUC16	mucin 16, cell surface associated	11.0	Publications
2	CLDN4	claudin 4	11.0	Publications
3	AREG	amphiregulin	11.0
4	CLU	clusterin	11.0
5	SELE	selectin E	11.0	Publications
6	BRCA1	breast cancer 1, early onset	11.0	Publications
7	TGFA	transforming growth factor, alpha	11.0
8	CMTM5	CKLF-like MARVEL transmembrane domain containing 5	11.0
9	CKLF	chemokine-like factor	11.0
10	CLDN3	claudin 3	11.0	Publications
11	FH	fumarate hydratase	11.0
12	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0	Publications
13	AHRR	aryl-hydrocarbon receptor repressor	11.0
14	LMNA	lamin A/C	11.0	Publications

Pathways related to ovarian cystadenoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	9.8	CLDN4, CLDN3

Compounds related to ovarian cystadenoma according to GeneDecks:

(show all 31)

id	Compound	Score	Top Affiliating Genes
1	8-chloro-camp32	10.2	AREG, TGFA
2	ochratoxin a32	10.0	CLDN4, CLDN3
3	topotecan32 9 9	11.9	TGFA, MUC16, BRCA1
4	heparin32 9 18 9	12.9	BRCA1, AREG, TGFA
5	pd15303532	9.8	TGFA, AREG
6	mitomycin c32	9.7	TGFA, AREG, BRCA1
7	sialic acid32	9.7	SELE, CLU, MUC16
8	4-hydroxytamoxifen32	9.6	TGFA, AREG, CLU, BRCA1
9	folate32	9.6	SELE, BRCA1, CLU, TGFA
10	polysaccharide32	9.5	SELE, CLU, AREG, TGFA
11	paclitaxel32 34 9 9	12.5	TGFA, MUC16, CLU, BRCA1
12	etoposide32 42 9 9	12.5	TGFA, CLU, BRCA1, SELE
13	tamoxifen32 34 9 9	12.5	TGFA, CLU, BRCA1, SELE
14	actinomycin d32	9.4	SELE, CLU, AREG, TGFA
15	paraffin32	9.4	TGFA, MUC16, CLU, BRCA1
16	estradiol32 9 18 9	12.4	TGFA, AREG, MUC16, CLU, BRCA1
17	cisplatin32 34 9 9	12.4	BRCA1, CLU, MUC16, AREG
18	doxorubicin32 34 9 9	12.4	TGFA, MUC16, CLU, BRCA1, SELE
19	dihydrotestosterone32 9 18 9	12.3	CLU, AREG, TGFA
20	cycloheximide32	9.3	TGFA, AREG, CLU, BRCA1, SELE
21	progesterone32 42 9 18 9	13.1	TGFA, AREG, MUC16, CLU, CLDN4, BRCA1
22	lactate32	9.1	SELE, CLU, MUC16, FH, TGFA
23	proline32	9.1	TGFA, FH, CLU, BRCA1
24	creatinine32	8.9	TGFA, FH, MUC16, LMNA, SELE
25	steroid32	8.8	TGFA, AREG, MUC16, LGR6, CLU, BRCA1
26	vegf32	8.6	TGFA, AREG, MUC16, CLDN3, CLU, BRCA1
27	estrogen32	8.5	TGFA, AREG, MUC16, LGR6, CLU, CLDN4
28	cholesterol32 9 18 9	11.5	SELE, LMNA, CLU, CLDN3, LGR6
29	testosterone32 9 18 9	11.5	SELE, TGFA, AREG, MUC16, LGR6, CLU
30	tyrosine32	8.0	TGFA, FH, AREG, MUC16, LGR6, CLU
31	serine32	7.7	TGFA, AREG, MUC16, LGR6, CLU, CLDN4

Cellular components related to ovarian cystadenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	perinuclear region of cytoplasm	GO:048471	9.0	SELE, LMNA, CLU, TGFA
2	extracellular space	GO:005615	8.2	SELE, TGFA, MUC16, CKLF, CLU, CMTM5

Biological processes related to ovarian cystadenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium-independent cell-cell adhesion	GO:016338	9.8	CLDN4, CLDN3

Molecular functions related to ovarian cystadenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:004888	9.5	SELE, CLDN4, CLDN3