MCID: OVR017
MIFTS: 36

Ovarian Cystic Teratoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Cystic Teratoma

MalaCards integrated aliases for Ovarian Cystic Teratoma:

Name: Ovarian Cystic Teratoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5118
NCIt 47 C7283
UMLS 69 C1335155

Summaries for Ovarian Cystic Teratoma

MalaCards based summary : Ovarian Cystic Teratoma is related to vitamin k deficiency hemorrhagic disease and familial renal oncocytoma. An important gene associated with Ovarian Cystic Teratoma is NECTIN2 (Nectin Cell Adhesion Molecule 2), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and colon, and related phenotype is neoplasm.

Related Diseases for Ovarian Cystic Teratoma

Diseases related to Ovarian Cystic Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 vitamin k deficiency hemorrhagic disease 10.8 FCGR3A FCGR3B
2 familial renal oncocytoma 10.8 CD226 KRT20 NECTIN2
3 transient cerebral ischemia 10.7 CALCA PVR
4 breast pericanalicular fibroadenoma 10.7 KRT20 NKX2-1
5 tibia absent polydactyly arachnoid cyst 10.7 NKX2-1 TG
6 panhypophysitis 10.7 NKX2-1 TG
7 cystic teratoma 10.6
8 teratoma 10.6
9 childhood mediastinal neurogenic tumor 10.6 CALCA TG
10 kidney disease 10.6 NECTIN2 NKX2-1 TG
11 spindle cell hemangioma 10.6 FCGR3A FCGR3B PVR
12 corneal ectasia 10.6 CALCA TG
13 parachordoma 10.6 NKX2-1 TG
14 cervical endometrial stromal sarcoma 10.5 CALCA TG
15 rett syndrome, congenital variant 10.5 FCGR3A FCGR3B
16 brachyolmia 10.5 CALCA KRT20 NKX2-1
17 mature teratoma 10.5 NKX2-1 TG
18 water-clear cell adenoma 10.5 CALCA PRL
19 congenital granular cell tumor 10.5 CALCA TG
20 sphenoid sinus squamous cell carcinoma 10.5 KRT20 NKX2-1
21 gorlin bushkell jensen syndrome 10.5 GAST KRT20
22 parietal lobe neoplasm 10.5 CALCA TG
23 spinal cord melanoma 10.5 ADAM17 MLANA
24 acral lentiginous melanoma 10.5 B2M FCGR3A IFNA2
25 neuroendocrine tumor of the colon 10.4 CALCA GAST
26 demyelinating polyneuropathy 10.4 NKX2-1 TG
27 meningovascular neurosyphilis 10.4 CALCA NKX2-1 TG
28 bladder diffuse clear cell adenocarcinoma 10.4 CALCA NKX2-1 TG
29 pandas 10.4 CALCA GAST
30 otosclerosis 10.3 CALCA NKX2-1 TG
31 lung lymphoma 10.3 B2M CALCA TG
32 melanoma 10.3
33 bone giant cell tumor 10.3 KRT20 KRT7
34 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.3 NKX2-1 TG
35 frontotemporal dementia and/or amyotrophic lateral sclerosis 4 10.3 CALCA NKX2-1 TG
36 rectum adenoma 10.3 KRT20 KRT7
37 sensory system cancer 10.3 KRT20 KRT7
38 steroid-induced glaucoma - borderline 10.3 KRT20 KRT7
39 ludwig's angina 10.3 KRT20 KRT7
40 lung occult small cell carcinoma 10.3 KRT20 KRT7
41 fibroepithelial polyp of urethra 10.3 KRT20 KRT7
42 clear cell squamous cell skin carcinoma 10.2 KRT20 KRT7
43 vulva squamous cell carcinoma 10.2 KRT20 KRT7
44 testicular trophoblastic tumor 10.2 KRT20 KRT7
45 intrahepatic cholangiocarcinoma 10.1 KRT20 KRT7
46 hordeolum 10.1 KRT20 KRT7
47 trachea adenoid cystic carcinoma 10.1 B2M KRT7
48 degenerative myopia 10.1 KRT20 KRT7
49 fibrolamellar carcinoma 10.1 CALCA NKX2-1 PRL TG
50 myotonia congenita 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Ovarian Cystic Teratoma:



Diseases related to Ovarian Cystic Teratoma

Symptoms & Phenotypes for Ovarian Cystic Teratoma

MGI Mouse Phenotypes related to Ovarian Cystic Teratoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 B2M CD226 GAST IRF4 NKX2-1 PRL

Drugs & Therapeutics for Ovarian Cystic Teratoma

Drugs for Ovarian Cystic Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
4
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6 Antibodies Phase 3,Phase 2,Phase 1
7 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
8 Anti-Infective Agents Phase 3,Phase 2
9 Antimetabolites Phase 3
10 Antiviral Agents Phase 3,Phase 2
11 Immunoglobulins Phase 3,Phase 2,Phase 1
12 Anti-Bacterial Agents Phase 3
13 Antifungal Agents Phase 3
14 Antiparasitic Agents Phase 3
15 Antiprotozoal Agents Phase 3
16 Echinocandins Phase 3
17 Liposomal amphotericin B Phase 3
18
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
19
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
20
Ifosfamide Approved Phase 2,Phase 1 3778-73-2 3690
21
Mechlorethamine Approved Phase 2,Phase 1 51-75-2 4033
22
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
23
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
24
Etoposide Approved Phase 2 33419-42-0 36462
25
Lenograstim Approved Phase 2,Phase 1 135968-09-1
26
Oprelvekin Approved, Investigational Phase 2 145941-26-0
27
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
28
Palbociclib Approved Phase 2 571190-30-2 11431660 5005498 5330286
29
nivolumab Approved Phase 2 946414-94-4
30
Mesna Approved Phase 2 3375-50-6 598
31 Thiotepa Approved Phase 2 52-24-4 5453
32 Angiogenesis Inhibitors Phase 2,Phase 1
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34 Albumin-Bound Paclitaxel Phase 2,Phase 1
35 Alkylating Agents Phase 2,Phase 1
36 Antimitotic Agents Phase 2,Phase 1
37 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
38 Isophosphamide mustard Phase 2,Phase 1
39 Etoposide phosphate Phase 2
40 Topoisomerase Inhibitors Phase 2
41 Adjuvants, Immunologic Phase 2,Phase 1
42 Anti-Asthmatic Agents Phase 1, Phase 2
43 Anti-Inflammatory Agents Phase 1, Phase 2
44
Beclomethasone Phase 1, Phase 2 4419-39-0 20469
45 glucocorticoids Phase 1, Phase 2
46 Hormone Antagonists Phase 1, Phase 2
47 Hormones Phase 1, Phase 2
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
49 Immunosuppressive Agents Phase 1, Phase 2
50 Respiratory System Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
2 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
6 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
7 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
8 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
9 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
10 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
11 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
14 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
15 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
16 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
17 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
18 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
19 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
20 Ovarian Mesial Incision: a New Safe and Fertility-sparing Technique Completed NCT01590030
21 Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis Completed NCT03020108
22 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
23 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465

Search NIH Clinical Center for Ovarian Cystic Teratoma

Genetic Tests for Ovarian Cystic Teratoma

Anatomical Context for Ovarian Cystic Teratoma

MalaCards organs/tissues related to Ovarian Cystic Teratoma:

39
Bone Marrow, Bone, Colon, Small Intestine, B Cells, Pituitary, Thymus

Publications for Ovarian Cystic Teratoma

Articles related to Ovarian Cystic Teratoma:

(show top 50) (show all 63)
id Title Authors Year
1
Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes. ( 28643027 )
2017
2
Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. ( 26980033 )
2016
3
Primitive neuroectodermal tumor in an ovarian cystic teratoma: natural killer and neuroblastoma cell analysis. ( 24575020 )
2014
4
Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. ( 25439346 )
2014
5
Ectopic prolactin-producing pituitary adenoma in a benign ovarian cystic teratoma. ( 24584638 )
2014
6
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
7
Synchronous Primary Endometrial Carcinoma and Metastatic Malignant Melanoma in an Ovarian Cystic Teratoma. ( 24715550 )
2014
8
A floating ball: a pathognomonic sign of ovarian cystic teratoma. ( 23764514 )
2013
9
Mature ovarian cystic teratoma (dermoid cyst). ( 22902841 )
2012
10
Intestinal obstruction due to bilateral ovarian cystic teratoma in a pregnant woman: report of a case. ( 21987947 )
2011
11
Conservative surgery in the management of a benign ovarian cystic teratoma presenting as a rectal mass: a case report. ( 21943447 )
2011
12
An unusual growth of ovarian cystic teratoma with multiple floating balls during pregnancy: a case report. ( 20544870 )
2010
13
Ovarian cystic teratoma torsion in pregnancy. ( 20810465 )
2010
14
Spontaneous rupture of benign ovarian cystic teratoma in a premenarcheal girl. ( 19576813 )
2009
15
A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma. ( 19521124 )
2009
16
Primary malignant melanoma arising in an ovarian cystic teratoma. ( 19317266 )
2009
17
Ovarian cystic teratoma with a pathognomonic appearance of multiple floating balls: a case report and investigation of common characteristics of the cases in the literature. ( 18304549 )
2008
18
Irregular dental structures in a benign ovarian cystic teratoma (dermoid cyst): case report. ( 18581775 )
2008
19
Giant mature ovarian cystic teratoma including more than 300 teeth. ( 18280952 )
2008
20
Ruptured ovarian cystic teratoma in pregnancy with diffuse peritoneal reaction mimicking advanced ovarian malignancy: a case report. ( 18549490 )
2008
21
Ruptured ovarian cystic teratoma secondary to blunt abdominal trauma: a very unusual case. ( 17308491 )
2007
22
Floating ball appearance in ovarian cystic teratoma. ( 16972218 )
2006
23
Pathogenesis of balls in mature ovarian cystic teratoma. Report of 3 cases and review of literature. ( 16990711 )
2006
24
Are they spherules of ovarian cystic teratoma or daughter cysts of echinococcosis? ( 17146747 )
2006
25
Unusual fast-growing ovarian cystic teratoma during pregnancy presenting with intracystic fat "floating balls" appearance. ( 17067585 )
2006
26
Ovarian cystic teratoma with primary epithelial cell melanoma. ( 15755005 )
2005
27
Monolateral mature ovarian cystic teratoma. ( 15746800 )
2005
28
Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. ( 16343199 )
2005
29
Mature ovarian cystic teratoma with a highly differentiated homunculus: a case report. ( 14745894 )
2004
30
MR and ultrasound imaging of floating globules in mature ovarian cystic teratoma. ( 15205564 )
2004
31
Small bowel perforation with minor trauma: a rare complication of an ovarian cystic teratoma. ( 12435956 )
2002
32
Adenocarcinoma arising from respiratory ciliated epithelium in mature ovarian cystic teratoma. ( 12439559 )
2002
33
Ovarian cystic teratoma: determined phenotypic response of keratocytes and uncommon intracystic floating balls appearance on sonography and computed tomography. ( 12054308 )
2002
34
Unusual "floating balls" appearance of an ovarian cystic teratoma: sonographic and CT findings. ( 11180183 )
2001
35
Analysis of 20 mature ovarian cystic teratoma cases in postmenopausal women. ( 11780192 )
2001
36
Amelanotic malignant melanoma arising in an ovarian cystic teratoma: a case report. ( 11575655 )
2001
37
Primary malignant melanoma in ovarian cystic teratoma. ( 11531299 )
2001
38
Radiology case of the month. Abdominal mass. Bilateral ovarian cystic teratoma. ( 10851824 )
2000
39
Thymus tissue in ovarian cystic teratoma: possible clues to its histogenesis. ( 11186178 )
2000
40
Conservative management of ovarian cystic teratoma during pregnancy and labor. ( 10739498 )
2000
41
Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma. ( 9808441 )
1998
42
Primary malignant melanoma arising in an ovarian cystic teratoma. ( 9743462 )
1998
43
Residents' corner. Answer to case of the month #41. Mature ovarian cystic teratoma. ( 8857976 )
1996
44
Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. ( 8886884 )
1996
45
p53 mutation in carcinomas arising in ovarian cystic teratomas. ( 8548037 )
1995
46
Small-cell epidermoid carcinoma with melanocyte colonization arising in a mature ovarian cystic teratoma. ( 7605174 )
1995
47
Combined microcystic adnexal carcinoma and squamous cell carcinoma arising in the ovarian cystic teratoma--a brief case report. ( 7702793 )
1994
48
Radiology rounds. Ovarian cystic teratoma (ovarian dermoid). ( 7950466 )
1994
49
Malignant melanoma arising in ovarian cystic teratoma. ( 1959792 )
1991
50
SEM contribution to the morphological study of dental structures in ovarian cystic teratoma. ( 2269940 )
1990

Variations for Ovarian Cystic Teratoma

Expression for Ovarian Cystic Teratoma

Search GEO for disease gene expression data for Ovarian Cystic Teratoma.

Pathways for Ovarian Cystic Teratoma

GO Terms for Ovarian Cystic Teratoma

Cellular components related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 ADAM17 B2M CD226 NECTIN2 PVR
2 external side of plasma membrane GO:0009897 9.26 B2M CD226 CD276 FCGR3A
3 cell-cell adherens junction GO:0005913 8.8 CD226 NECTIN2 PVR

Biological processes related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 CD226 NECTIN2 PVR
2 T-helper 17 cell lineage commitment GO:0072540 9.48 IRF4 SLAMF6
3 susceptibility to natural killer cell mediated cytotoxicity GO:0042271 9.43 NECTIN2 PVR
4 cell recognition GO:0008037 9.43 CD226 NECTIN2 PVR
5 susceptibility to T cell mediated cytotoxicity GO:0060370 9.4 NECTIN2 PVR
6 positive regulation of immunoglobulin mediated immune response GO:0002891 9.37 CD226 NECTIN2
7 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 9.33 CD226 NECTIN2 PVR
8 positive regulation of mast cell activation GO:0033005 9.32 CD226 NECTIN2
9 positive regulation of natural killer cell mediated cytotoxicity GO:0045954 9.26 CD226 NECTIN2 PVR SLAMF6
10 regulation of immune response GO:0050776 9.17 B2M CD226 CD276 FCGR3A NECTIN2 PVR

Molecular functions related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.16 FCGR3A FCGR3B
2 cell adhesion molecule binding GO:0050839 9.13 CD226 NECTIN2 PVR
3 hormone activity GO:0005179 8.92 CALCA GAST PRL TG
4 protein binding GO:0005515 10.16 ADAM17 B2M CALCA CD226 CD276 GAST

Sources for Ovarian Cystic Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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