MCID: OVR049
MIFTS: 58

Ovarian Disease

Categories: Endocrine diseases, Rare diseases, Genetic diseases, Reproductive diseases

Aliases & Classifications for Ovarian Disease

MalaCards integrated aliases for Ovarian Disease:

Name: Ovarian Disease 12 14
Ovarian Dysfunction 12 51 14
Ovarian Diseases 51 41 69
Disorder of Endocrine Ovary 69
Ovarian Disorders 40

Classifications:



External Ids:

Disease Ontology 12 DOID:1100 DOID:1414
MeSH 41 D010049
NCIt 46 C26841
ICD9CM 34 256.3 256.39
ICD10 32 E28 E28.3 E28.9

Summaries for Ovarian Disease

MedlinePlus : 40 The ovaries are part of the female reproductive system. Women have two ovaries, one on each side of the uterus. Each ovary is about the size and shape of an almond. The ovaries produce and store a woman's eggs. During ovulation, an ovary releases an egg. If that egg is fertilized by a sperm, a pregnancy can occur. Ovaries also make the female hormones estrogen and progesterone. When a woman goes through menopause, her ovaries stop making those hormones and releasing eggs. Problems with the ovaries include Ovarian cancer Ovarian cysts and polycystic ovary syndrome Premature ovarian failure Ovarian torsion, a twisting of the ovary

MalaCards based summary : Ovarian Disease, also known as ovarian dysfunction, is related to polycystic ovary syndrome and hyperprolactinemia, and has symptoms including mittelschmerz and pelvic pain. An important gene associated with Ovarian Disease is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Fertilization. The drugs Metformin and Cyproterone Acetate have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and testes, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 Ovarian diseases can be classified as endocrine disorders or as a disorders of the reproductive... more...

Related Diseases for Ovarian Disease

Diseases in the Ovarian Disease family:

Ovarian Insufficiency, Familial Ovarian Insufficiency Due to Fsh Resistance

Diseases related to Ovarian Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 polycystic ovary syndrome 30.6 CYP19A1 FSHR GDF9 GNRH1 IGF1 IGFBP1
2 hyperprolactinemia 30.2 GNRH1 IGF1 PRL
3 hyperinsulinism 30.0 IGF1 IGFBP1 INS SHBG
4 insulin-like growth factor i 29.9 IGF1 IGFBP1 INS PRL SHBG
5 hypogonadotropism 29.9 GNRH1 PRL
6 luteoma 29.8 CGA CYP19A1
7 pituitary gland disease 29.6 GNRH1 IGF1 INS PRL
8 hyperandrogenism 29.5 CYP19A1 GNRH1 IGF1 IGFBP1 INS PRL
9 endometrial cancer 29.1 CYP19A1 GNRH1 IGF1 IGFBP1 INS SHBG
10 ovarian hyperstimulation syndrome 29.1 AMH CGA CYP19A1 FSHR GNRH1
11 infertility 29.0 CYP19A1 FSHR GNRH1 PRL ZP1 ZP3
12 anovulation 28.6 BMP15 CGA CYP19A1 FSHR GNRH1 IGF1
13 amenorrhea 28.2 BMP15 FSHR GNRH1 NOBOX POF1B PRL
14 premature ovarian failure 1 27.6 AMH BMP15 CYP19A1 FMR1 FOXL2 FSHR
15 mullerian aplasia and hyperandrogenism 11.1
16 leukoencephalopathy with vanishing white matter 10.9
17 secondary adrenal insufficiency 10.5 IGF1 INS
18 galactorrhea 10.5 IGF1 PRL
19 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.5 IGF1 INS
20 hypoactive sexual desire disorder 10.5 CYP19A1 SHBG
21 hyperproinsulinemia 10.5 IGFBP1 INS SHBG
22 endometriosis of uterus 10.5 GNRH1 PRL
23 pseudohypoparathyroidism, type ia 10.5 IGF1 PRL
24 sheehan syndrome 10.5 IGF1 INS PRL
25 pituitary apoplexy 10.5 GNRH1 INS PRL
26 empty sella syndrome 10.5 GNRH1 INS PRL
27 hyperpituitarism 10.5 IGF1 INS PRL
28 hypothalamic disease 10.5 GNRH1 PRL
29 precocious puberty, male-limited 10.5 CYP19A1 FSHR
30 pituitary infarct 10.5 GNRH1 IGF1 PRL
31 chiasmal syndrome 10.5 GNRH1 PRL
32 pituitary adenoma 1, multiple types 10.4 IGF1 PRL
33 thyroid gland disease 10.4 IGF1 INS PRL
34 chromophobe adenoma 10.4 GNRH1 INS PRL
35 androgenic alopecia 10.4 CYP19A1 PRL SHBG
36 premenstrual tension 10.4 GNRH1 PRL SHBG
37 cell type benign neoplasm 10.4 IGF1 INS PRL
38 mammographic density 10.4 CYP19A1 IGF1 PRL
39 pituitary-dependent cushing's disease 10.4 GNRH1 INS PRL
40 overnutrition 10.4 IGF1 INS SHBG
41 aromatase deficiency 10.4 CYP19A1 GNRH1 INS
42 androgen insensitivity, partial 10.4 CYP19A1 SHBG
43 turner syndrome 10.4 IGF1 IGFBP1 SHBG
44 estrogen excess 10.4 CYP19A1 FSHR SHBG
45 complete androgen insensitivity syndrome 10.4 CGA CYP19A1 SHBG
46 male reproductive organ cancer 10.4 GNRH1 IGF1 SHBG
47 central precocious puberty 10.4 GNRH1 IGF1
48 breast disease 10.4 IGF1 PRL SHBG
49 granulosa cell tumor of the ovary 10.4 FOXL2 INS PRL
50 leiomyoma, uterine 10.4 CYP19A1 GNRH1 IGF1

Graphical network of the top 20 diseases related to Ovarian Disease:



Diseases related to Ovarian Disease

Symptoms & Phenotypes for Ovarian Disease

UMLS symptoms related to Ovarian Disease:


mittelschmerz, pelvic pain

MGI Mouse Phenotypes related to Ovarian Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.83 AMH BMP15 CGA CYP19A1 FMR1 FOXL2
2 reproductive system MP:0005389 9.5 PRL ZP1 ZP3 AMH BMP15 CGA

Drugs & Therapeutics for Ovarian Disease

Drugs for Ovarian Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 684)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 657-24-9 4091 14219
2
Cyproterone Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 427-51-0
3
Drospirenone Approved Phase 4,Phase 3,Phase 1 67392-87-4 68873
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757
5
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-63-6 5991
6
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
7
Ganirelix Approved Phase 4,Phase 2,Early Phase 1 124904-93-4, 123246-29-7 25081094
8
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 57-83-0 5994
9
Leuprolide Approved, Investigational Phase 4,Phase 2,Early Phase 1 53714-56-0 657181 3911
10
Menotropins Approved Phase 4,Phase 2,Phase 1 9002-68-0, 61489-71-2 5360545
11
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
12
Pioglitazone Approved, Investigational Phase 4,Early Phase 1 111025-46-8 4829
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
14
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
15
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
16
Zinc Approved, Investigational Phase 4,Early Phase 1 7440-66-6 32051 23994
17
Hydrocortisone Approved, Vet_approved Phase 4,Early Phase 1 50-23-7 657311 5754
18
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 1 501-36-0 445154
19
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 135968-09-1
20
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 216974-75-3
21
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
22
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
23
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
24
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 71-58-9
25
Olaparib Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 763113-22-0 23725625
26
Buserelin Approved, Investigational Phase 4 57982-77-1
27
Nafarelin Approved Phase 4 76932-56-4 25077649 16129618
28
Aspirin Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 50-78-2 2244
29
Liraglutide Approved Phase 4 204656-20-2 44147092
30
Alogliptin Approved Phase 4 850649-61-5 11450633
31
Danazol Approved Phase 4 17230-88-5 28417
32
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 616-91-1 12035
33
Citalopram Approved Phase 4 59729-33-8 2771
34
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 51-43-4 5816
35 Racepinephrine Approved Phase 4,Phase 2,Phase 3,Early Phase 1 329-65-7
36
Tranexamic Acid Approved Phase 4 1197-18-8 5526
37
Norethindrone Approved Phase 4,Phase 2,Early Phase 1 68-22-4 6230
38
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
39
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
40
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
41
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
42
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
43
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
44
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2 141758-74-9 15991534
45
Desogestrel Approved Phase 4,Phase 3,Phase 2 54024-22-5 40973
46
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1,Phase 2 83-43-2 6741
47
Prednisolone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-24-8 5755
48
Iron Approved Phase 4,Phase 2 7439-89-6 23925
49
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
50
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 2226)

# Name Status NCT ID Phase Drugs
1 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
2 The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation Unknown status NCT01631253 Phase 4
3 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
4 Effects of ADSC Therapy in Women With POF Unknown status NCT01853501 Phase 4
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
6 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
7 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
8 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
9 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
10 The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
11 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
12 Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients Unknown status NCT00417144 Phase 4 Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
13 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
14 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
15 Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS Completed NCT01815138 Phase 4 hCG;hCG
16 Endometrial Receptivity After GnRH Agonist Triggering Completed NCT01500863 Phase 4 hCG;triptorelin;Triptorelin, estradiol valerate, micronized vaginal progesterone;triptorelin, hCG;triptorelin, hCG;triptorelin, recombinant LH
17 Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles Completed NCT00627406 Phase 4 Buserelin and Pregnyl;Pregnyl;Buserelin and Pregnyl;Pregnyl
18 The Use of GnRH Agonist Trigger in the Prevention of OHSS Completed NCT00349258 Phase 4 Leuprolide acetate
19 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4 Menopur
20 Short Versus Long Protocol for IVF and IVF+ICSI Completed NCT00756028 Phase 4 Patients receiving short protocol IVF/ICSI-treatment.;Long protocol
21 Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH Completed NCT00417157 Phase 4 recombinant FSH (Puregon, Organon, The Netherlands);GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands);hCG (Pregnyl, Organon, The Netherlands)
22 Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders Completed NCT00417066 Phase 4 Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands);Arvekap 0.1mg (Triptorelin, Ipsen, France)
23 Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS Completed NCT02670304 Phase 4 letrozole;Aspirin
24 The Role of Estrogen in Luteinizing Hormone Surge and Ovulation Completed NCT01999569 Phase 4 Letrozole
25 Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome Completed NCT03122041 Phase 4 Sitagliptin
26 Weight Maintenance With Dipeptidyl Peptidase 4 (DPP4) Inhibitor Sitagliptin in Combination With Metformin After Liragludite Induced Weight Loss Completed NCT02941445 Phase 4 sitagliptin and metformin;Metformin
27 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
28 Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome Completed NCT02483299 Phase 4 Metformin;Glucophage tablets and Victoza
29 Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS Completed NCT02352597 Phase 4 phytoestrogen;estradiol valerate;clomiphene citrate
30 PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome Completed NCT02187250 Phase 4 metformin;liraglutide;roflumilast
31 PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome Completed NCT02037672 Phase 4 metformin;metformin and roflumilast
32 Clinical Evaluation of Furocyst in Patients With Poly Cystic Ovary Syndrome Completed NCT02789488 Phase 4
33 Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin Completed NCT01911468 Phase 4 metformin;liraglutide;metformin and liraglutide
34 Polycystic Ovary Syndrome and Liraglutide Completed NCT01899430 Phase 4 liraglutide;metformin
35 The Effect of a Liraglutide on IVF in Obese PCOS Completed NCT03353948 Phase 4 MET;COMBI
36 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4 medical nutrition therapy + metformin
37 The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies. Completed NCT03384511 Phase 4 Apatinib
38 A Random Clinical Trial (RCT) of the Impact of Electrocoagulation on Ovarian Reserve Completed NCT00746278 Phase 4
39 The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst Completed NCT00713778 Phase 4
40 Low Dose Liraglutide and Metformin vs. High Dose Liraglutide Alone in Treatment of Obesity Completed NCT02909933 Phase 4 liraglutide;metformin and liraglutide
41 hMG or Recombinant FSH on OHSS Prevention in PCOS Patients Undergoing IVF Completed NCT01365936 Phase 4 HMG;rFSH
42 The Effects of Vitamin D on Transforming Growth Factor-beta1 in Polycystic Ovary Syndrome Completed NCT02460380 Phase 4 Vitamin D3
43 Epicardial Adipose Tissue Thickness in Polycystic Ovary Syndrome (PCOS) Completed NCT01258946 Phase 4
44 Comparison of Alogliptin Versus Alogliptin and Pioglitazone on Insulin Resistance of Metformin Treated Women With PCOS Completed NCT02683226 Phase 4 Vipdomet;Incresync
45 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
46 Protexa® Versus TiLoopBra® in Immediate Breast Reconstruction- A Pilot Study Completed NCT02562170 Phase 4
47 Trial With Metformin in Women With Polycystic Ovary Syndrome Completed NCT02280057 Phase 4 Metformin;Placebo
48 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
49 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed NCT02073929 Phase 4 Liraglutide;placebo
50 The Effect of Cipralex on Quality of Life, Adrenal Activity Glucose Metabolism, Physical and Mental Health in PCOS Completed NCT01961180 Phase 4 Cipralex;Placebo

Search NIH Clinical Center for Ovarian Disease

Cochrane evidence based reviews: ovarian diseases

Genetic Tests for Ovarian Disease

Anatomical Context for Ovarian Disease

MalaCards organs/tissues related to Ovarian Disease:

38
Ovary, Breast, Testes, Lung, T Cells, Bone, Liver

Publications for Ovarian Disease

Articles related to Ovarian Disease:

(show top 50) (show all 450)
# Title Authors Year
1
Tumor necrosis factor alpha versus LH and androstendione as a reliable predictor of spontaneous ovulation after laparoscopic ovarian drilling for women with clomiphene citrate resistance polycystic ovarian disease. ( 29408743 )
2018
2
Natural history of autoimmune primary ovarian insufficiency in patients with Addison's disease: from normal ovarian function to overt ovarian dysfunction. ( 28733292 )
2017
3
Polycystic Ovarian Disease (Stein-Leventhal Syndrome) ( 29083730 )
2017
4
Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial. ( 28479118 )
2017
5
The role of regulatory T cells in thymectomy-induced autoimmune ovarian disease. ( 28660639 )
2017
6
Thyroid function/antibodies in sudanese women with polycystic ovarian disease. ( 28344960 )
2017
7
Efficacy of Combined Cabergoline and Metformin Compared to Metformin Alone on Cycle Regularity in Patients with Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial. ( 28867888 )
2017
8
Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary. ( 26677854 )
2016
9
BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development. ( 27486268 )
2016
10
A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease. ( 27127318 )
2016
11
Involvement of Matrix Metalloproteinases and their Inhibitors in Bovine Cystic Ovarian Disease. ( 27993358 )
2016
12
Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease. ( 27834809 )
2016
13
Polycystic ovarian disease and associated factors. ( 27075885 )
2016
14
Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials. ( 26657509 )
2016
15
Adiponectin Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice. ( 27700136 )
2016
16
"Empiric" inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. ( 25687659 )
2015
17
Molecular aspects of bovine cystic ovarian disease pathogenesis. ( 25767139 )
2015
18
Authors' reply to: "Empiric" inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. ( 25687660 )
2015
19
Involvement of PAPP-A and IGFR1 in Cystic Ovarian Disease in Cattle. ( 26031184 )
2015
20
Oral contraceptive pills induced hemichorea in an adolescent female with polycystic ovarian disease. ( 25878392 )
2015
21
Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease. ( 26065705 )
2015
22
Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease. ( 25813700 )
2015
23
A novel serum microRNA panel to discriminate benign from malignant ovarian disease. ( 25451316 )
2015
24
Anti-mA1llerian hormone and insulin-like 3 levels in healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females: potential early biomarkers of ovarian dysfunction? ( 26579638 )
2015
25
Can treatment for polycystic ovarian disease induce ovarian tumour? A case report. ( 24596770 )
2014
26
GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats. ( 25263979 )
2014
27
Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease. ( 25001504 )
2014
28
Polycystic ovarian disease: still an enigma! ( 24685855 )
2014
29
Epidemiological description of cystic ovarian disease in argentine dairy herds: risk factors and effects on the reproductive performance of lactating cows. ( 25292292 )
2014
30
Ovarian dysfunction, obesity and pituitary tumors in female mice following neonatal exposure to low-dose diethylstilbestrol. ( 25450423 )
2014
31
Women with clomiphene citrate resistant polycystic ovarian disease: predictors of spontaneous ovulation after laparoscopic ovarian drilling. ( 24576485 )
2014
32
Altered expression of transforming growth factor-beta isoforms in bovine cystic ovarian disease. ( 25112788 )
2014
33
Adrenal ganglioneuroma in a patient with polycystic ovarian disease (PCOD): a rare association. ( 24145507 )
2013
34
Cutting edge: Ly49C/Ia8> neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. ( 23960238 )
2013
35
Study of FMR1 gene association with ovarian dysfunction in a sample from the Basque Country. ( 23537988 )
2013
36
Ovarian localization of 11I^-hydroxysteroid dehydrogenase (11I^HSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. ( 23972491 )
2013
37
Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease. ( 23693122 )
2013
38
Assisted reproduction in polycystic ovarian disease: A multicentric trial in India. ( 23869152 )
2013
39
Changes in the expression of Heat Shock Proteins in ovaries from bovines with cystic ovarian disease induced by ACTH. ( 23937990 )
2013
40
Doppler imaging in the diagnosis of ovarian disease. ( 23480621 )
2012
41
Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: a career retrospective. ( 22028409 )
2012
42
Effect of shatapushpa taila matra basti and pathadi kwatha on poly cystic ovarian disease. ( 23559797 )
2012
43
Tolerogenic DNA vaccine for prevention of autoimmune ovarian disease. ( 22221010 )
2012
44
Environmental toxicants induce ovarian disease across generations. ( 23275984 )
2012
45
A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. ( 22349439 )
2012
46
Steroid receptor mRNA expression in the ovarian follicles of cows with cystic ovarian disease. ( 21536311 )
2012
47
Extremely elevated CA-125 in benign ovarian disease due to stretch of the peritoneum. ( 23188839 )
2012
48
Environmentally induced epigenetic transgenerational inheritance of ovarian disease. ( 22570695 )
2012
49
Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle. ( 21940120 )
2011
50
A case of successful treatment of comorbid obesity and polycystic ovarian disease with add-on metformin in bipolar disorder. ( 22295263 )
2011

Variations for Ovarian Disease

Expression for Ovarian Disease

Search GEO for disease gene expression data for Ovarian Disease.

Pathways for Ovarian Disease

GO Terms for Ovarian Disease

Cellular components related to Ovarian Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AMH BMP15 GDF9 GNRH1 IGF1 IGFBP1
2 extracellular region GO:0005576 9.44 AMH BMP15 CGA GDF9 GNRH1 IGF1
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Ovarian Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.87 AMH CGA GNRH1 INS
2 cellular protein metabolic process GO:0044267 9.77 BMP15 IGF1 IGFBP1 INS PRL
3 BMP signaling pathway GO:0030509 9.72 AMH BMP15 GDF9
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.7 FSHR IGF1 INS
5 regulation of MAPK cascade GO:0043408 9.69 BMP15 FSHR GDF9
6 binding of sperm to zona pellucida GO:0007339 9.63 ZP1 ZP3 ZP4
7 positive regulation of glycolytic process GO:0045821 9.58 IGF1 INS
8 female gonad development GO:0008585 9.58 CYP19A1 FOXL2 FSHR
9 positive regulation of glycogen biosynthetic process GO:0045725 9.56 IGF1 INS
10 single fertilization GO:0007338 9.56 FOXL2 ZP1 ZP3 ZP4
11 positive regulation of acrosome reaction GO:2000344 9.54 ZP3 ZP4
12 female gamete generation GO:0007292 9.5 BMP15 FSHR GDF9
13 positive regulation of humoral immune response GO:0002922 9.49 ZP3 ZP4
14 negative regulation of binding of sperm to zona pellucida GO:2000360 9.48 ZP3 ZP4
15 oocyte growth GO:0001555 9.43 FOXL2 GDF9
16 uterus development GO:0060065 9.33 CYP19A1 FOXL2 FSHR
17 regulation of receptor activity GO:0010469 9.28 AMH BMP15 CGA GDF9 GNRH1 IGF1
18 gonad development GO:0008406 9.13 AMH CGA FSHR

Molecular functions related to Ovarian Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 AMH BMP15 GDF9 IGF1
2 insulin-like growth factor receptor binding GO:0005159 9.32 IGF1 INS
3 acrosin binding GO:0032190 9.16 ZP3 ZP4
4 transforming growth factor beta receptor binding GO:0005160 9.13 AMH BMP15 GDF9
5 hormone activity GO:0005179 9.1 AMH CGA GNRH1 IGF1 INS PRL

Sources for Ovarian Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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