MCID: OVR049
MIFTS: 54

Ovarian Disease

Categories: Endocrine diseases, Reproductive diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Ovarian Disease

MalaCards integrated aliases for Ovarian Disease:

Name: Ovarian Disease 12 14
Ovarian Dysfunction 12 52 14
Ovarian Diseases 52 42 69
Disorder of Endocrine Ovary 69
Ovarian Disorders 41

Classifications:



External Ids:

Disease Ontology 12 DOID:1100 DOID:1414
MeSH 42 D010049
NCIt 47 C26841
ICD9CM 35 256.3 256.39
ICD10 33 E28 E28.3 E28.9

Summaries for Ovarian Disease

MedlinePlus : 41 the ovaries are part of the female reproductive system. women have two ovaries, one on each side of the uterus. each ovary is about the size and shape of an almond. the ovaries produce and store a woman's eggs. during ovulation, an ovary releases an egg. if that egg is fertilized by a sperm, a pregnancy can occur. ovaries also make the female hormones estrogen and progesterone. when a woman goes through menopause, her ovaries stop making those hormones and releasing eggs. problems with the ovaries include ovarian cancer ovarian cysts and polycystic ovary syndrome premature ovarian failure ovarian torsion, a twisting of the ovary

MalaCards based summary : Ovarian Disease, also known as ovarian dysfunction, is related to endometriosis and ovarian hyperstimulation syndrome, and has symptoms including pelvic pain and mittelschmerz. An important gene associated with Ovarian Disease is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Prolactin Signaling Pathway and Peptide hormone metabolism. The drugs Metformin and Ganirelix have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and lung, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Ovarian diseases can be classified as endocrine disorders or as a disorders of the reproductive... more...

Related Diseases for Ovarian Disease

Diseases in the Ovarian Disease family:

Ovarian Insufficiency, Familial Fmr1-Related Primary Ovarian Insufficiency
Ovarian Insufficiency Due to Fsh Resistance

Diseases related to Ovarian Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 endometriosis 30.0 PRL SHBG
2 ovarian hyperstimulation syndrome 28.7 AMH CGA CYP19A1 FSHR GNRH1 REN
3 selenium poisoning 10.8 IGF1 INS
4 mullerian aplasia and hyperandrogenism 10.8
5 polyneuropathy 10.8 CYP19A1 SHBG
6 african histoplasmosis 10.8 GNRH1 PRL
7 maturity-onset diabetes of the young, type 10 10.8 IGFBP1 INS SHBG
8 prostate leiomyoma 10.8 GNRH1 PRL
9 osteopathia striata with cranial sclerosis 10.8 CYP19A1 SHBG
10 leukoencephalopathy with vanishing white matter 10.7
11 adenomatoid tumor 10.7 GNRH1 PRL
12 ulcerative blepharitis 10.7 IGF1 INS PRL
13 protein s deficiency 10.7 IGF1 INS PRL
14 vertebral artery occlusion 10.7 GNRH1 INS PRL
15 repetitive stress injuries 10.7 INS REN
16 lactic acidosis 10.7 GNRH1 INS PRL
17 precocious puberty, male 10.7 CYP19A1 FSHR
18 intermittent squint 10.7 GNRH1 PRL
19 internal hemorrhoid 10.7 GNRH1 PRL SHBG
20 fibrolamellar carcinoma 10.7 IGF1 INS PRL
21 diencephalic neoplasm 10.7 GNRH1 INS PRL
22 lymphoepithelioma-like carcinoma 10.7 GNRH1 PRL
23 glioblastoma proneural subtype 10.7 CYP19A1 PRL SHBG
24 acute myocarditis 10.7 GNRH1 INS PRL
25 aromatase excess syndrome 10.7 CYP19A1 GNRH1 INS
26 inherited metabolic disorder 10.7 IGF1 INS SHBG
27 bile duct signet ring cell carcinoma 10.7 IGF1 IGFBP1 SHBG
28 complement component 8 deficiency 10.6 GNRH1 IGF1
29 medullomyoblastoma 10.6 GNRH1 IGF1 SHBG
30 paroxysmal nonkinesigenic dyskinesia 2 10.6 IGFBP1 INS
31 condrodisplasia punctata rizomélica 10.6 CGA CYP19A1 SHBG
32 polycystic ovary syndrome 10.6
33 alpha-methylacyl-coa racemase deficiency 10.6 GNRH1 IGF1 PRL
34 plague 10.6 IGF1 PRL SHBG
35 acute thyroiditis 10.6 CYP19A1 FSHR SHBG
36 androgen insensitivity, partial, with or without breast cancer 10.6 CGA CYP19A1 SHBG
37 cardiovascular organ benign neoplasm 10.6 IGF1 PRL REN
38 ocular hypotension 10.6 CGA CYP19A1
39 hypertensive encephalopathy 10.6 INS PRL REN
40 diabetic encephalopathy 10.6 IGF1 INS REN
41 periampullary adenoma 10.6 IGF1 INS REN
42 vestibular gland benign neoplasm 10.6 IGF1 PRL REN
43 renal-hepatic-pancreatic dysplasia 10.6 CGA GNRH1 IGF1
44 premature ovarian failure 1 10.6
45 hypertrichosis 10.6 IGF1 INS REN
46 short bowel syndrome 10.6 IGF1 IGFBP1 INS SHBG
47 exostosis 10.5 IGF1 IGFBP1 INS SHBG
48 uterine ligament clear cell adenocarcinoma 10.5 GNRH1 IGF1 INS PRL
49 adamantinous craniopharyngioma 10.5 GNRH1 IGF1 INS PRL
50 pepck 1 deficiency 10.5 CGA GNRH1

Graphical network of the top 20 diseases related to Ovarian Disease:



Diseases related to Ovarian Disease

Symptoms & Phenotypes for Ovarian Disease

UMLS symptoms related to Ovarian Disease:


pelvic pain, mittelschmerz

MGI Mouse Phenotypes related to Ovarian Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10 AMH BMP15 CGA CYP19A1 FMR1 FOXL2
2 homeostasis/metabolism MP:0005376 9.73 GDF9 GNRH1 IGF1 INS PRL REN
3 reproductive system MP:0005389 9.5 GDF9 GNRH1 IGF1 INS PRL REN

Drugs & Therapeutics for Ovarian Disease

Drugs for Ovarian Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 710)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
2
Ganirelix Approved Phase 4,Phase 3,Phase 2,Early Phase 1 123246-29-7, 124904-93-4 25081094
3
Cyproterone Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 427-51-0
4
Drospirenone Approved Phase 4,Phase 3,Phase 1 67392-87-4 68873
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757
6
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-63-6 5991
7
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
8
Ezetimibe Approved Phase 4 163222-33-1 150311
9
Cetrorelix Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 120287-85-6 16129715 25074887
10
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
11
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2 53714-56-0 3911 657181
12
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
13
Buserelin Approved Phase 4,Phase 3 57982-77-1
14
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
15
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
16
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
17
Pioglitazone Approved, Investigational Phase 4,Early Phase 1 111025-46-8 4829
18
Zinc Approved Phase 4,Early Phase 1 7440-66-6 32051 23994
19
Levonorgestrel Approved, Investigational Phase 4,Phase 2 797-63-7, 17489-40-6 13109
20
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
21
Tamoxifen Approved Phase 4,Phase 3,Phase 2,Phase 1 10540-29-1 2733526
22
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 216974-75-3
23
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
24
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
25
Lenograstim Approved Phase 4,Phase 3,Phase 1,Phase 2 135968-09-1
26
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
27
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 71-58-9
28
Olaparib Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 763113-22-0 23725625
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
30
Menotropins Approved Phase 4,Phase 1,Phase 2 61489-71-2, 9002-68-0 5360545
31
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
32
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 616-91-1 12035
33
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
34
Tranexamic Acid Approved Phase 4 1197-18-8 5526
35
Liraglutide Approved Phase 4 204656-20-2 44147092
36
Norethindrone Approved Phase 4,Phase 2,Phase 3,Early Phase 1 68-22-4 6230
37
Danazol Approved Phase 4 17230-88-5 28417
38
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
39
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
40
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
41
Citalopram Approved Phase 4 59729-33-8 2771
42
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
43 Racepinephrine Approved Phase 4,Phase 2,Phase 3
44
Moxonidine Approved Phase 4 75438-57-2 4810
45
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
46
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
47
Alogliptin Approved Phase 4 850649-61-5 11450633
48
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
49
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2 141758-74-9 15991534
50
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 1 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 2420)

id Name Status NCT ID Phase Drugs
1 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
2 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
3 The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation Unknown status NCT01631253 Phase 4
4 Effects of ADSC Therapy in Women With POF Unknown status NCT01853501 Phase 4
5 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
6 Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients Unknown status NCT00417144 Phase 4 Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
7 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
8 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
9 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
10 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
11 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
12 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
13 The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
14 Ovarian Tissue Freezing For Fertility Preservation Unknown status NCT00902720 Phase 4
15 A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis Unknown status NCT00433823 Phase 4 Atorvastatin, Ezetimibe
16 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
17 The Use of GnRH Agonist Trigger in the Prevention of OHSS Completed NCT00349258 Phase 4 Leuprolide acetate
18 Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS Completed NCT01815138 Phase 4 hCG;hCG
19 Endometrial Receptivity After GnRH Agonist Triggering Completed NCT01500863 Phase 4 hCG;triptorelin;Triptorelin, estradiol valerate, micronized vaginal progesterone;triptorelin, hCG;triptorelin, hCG;triptorelin, recombinant LH
20 Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles Completed NCT00627406 Phase 4 Buserelin and Pregnyl;Pregnyl;Buserelin and Pregnyl;Pregnyl
21 Tumor Gene Expression in Women With Ovarian Cancer Completed NCT00817479 Phase 4 Dexamethasone;Placebo
22 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4 Menopur
23 Short Versus Long Protocol for IVF and IVF+ICSI Completed NCT00756028 Phase 4 Patients receiving short protocol IVF/ICSI-treatment.;Long protocol
24 Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders Completed NCT00417066 Phase 4 Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands);Arvekap 0.1mg (Triptorelin, Ipsen, France)
25 Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH Completed NCT00417157 Phase 4 recombinant FSH (Puregon, Organon, The Netherlands);GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands);hCG (Pregnyl, Organon, The Netherlands)
26 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
27 The Role of Estrogen in Luteinizing Hormone Surge and Ovulation Completed NCT01999569 Phase 4 Letrozole
28 The Effects of Vitamin D on Transforming Growth Factor-beta1 in Polycystic Ovary Syndrome Completed NCT02460380 Phase 4 Vitamin D3
29 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
30 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo
31 Clinical Evaluation of Furocyst in Patients With Poly Cystic Ovary Syndrome Completed NCT02789488 Phase 4
32 The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst Completed NCT00713778 Phase 4
33 A Random Clinical Trial (RCT) of the Impact of Electrocoagulation on Ovarian Reserve Completed NCT00746278 Phase 4
34 Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS Completed NCT02670304 Phase 4 letrozole;Aspirin
35 Growth Response in Girls With Turner Syndrome Completed NCT01734486 Phase 4 somatropin;somatropin
36 Safety of Somatropin and Induction of Puberty With 17-beta-oestradiol in Girls With Turner Syndrome Completed NCT01518062 Phase 4 somatropin;somatropin;somatropin;oestrogen
37 Tranexamic Acid in Surgery of Advanced Ovarian Cancer Completed NCT00740116 Phase 4 Tranexamic acid;0.9% NaCl solution
38 A Study to Evaluate Efficacy and Tolerance of Caelyx in Patients With Epithelial Ovarian Cancer. (Study P04072)(COMPLETED) Completed NCT00727961 Phase 4 Pegylated Liposomal Doxorubicin hydrochloride
39 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed NCT02073929 Phase 4 Liraglutide;placebo
40 Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure Completed NCT00732693 Phase 4 Ethinylestradiol / Norethisterone;Estradiol / Progesterone
41 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
42 Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS Completed NCT02352597 Phase 4 phytoestrogen;estradiol valerate;clomiphene citrate
43 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
44 hMG or Recombinant FSH on OHSS Prevention in PCOS Patients Undergoing IVF Completed NCT01365936 Phase 4 HMG;rFSH
45 Metformin and Oral Contraceptives in PCOS Completed NCT00451568 Phase 4 Metformin;Desorelle
46 Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Completed NCT01675843 Phase 4
47 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed NCT00805935 Phase 4 Menotropin;Progesterone vaginal insert;Follitropin beta;Progesterone in oil;leuprolide acetate
48 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4 Metformin plus clomiphene citrate
49 Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome Completed NCT00492882 Phase 4 usual administration of exogenous recombinant FSH
50 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate

Search NIH Clinical Center for Ovarian Disease

Cochrane evidence based reviews: ovarian diseases

Genetic Tests for Ovarian Disease

Anatomical Context for Ovarian Disease

MalaCards organs/tissues related to Ovarian Disease:

39
Ovary, Testes, Lung, Bone, T Cells, Liver, Breast

Publications for Ovarian Disease

Articles related to Ovarian Disease:

(show top 50) (show all 420)
id Title Authors Year
1
The role of regulatory T cells in thymectomy-induced autoimmune ovarian disease. ( 28660639 )
2017
2
Efficacy of Combined Cabergoline and Metformin Compared to Metformin Alone on Cycle Regularity in Patients with Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial. ( 28867888 )
2017
3
Thyroid function/antibodies in sudanese women with polycystic ovarian disease. ( 28344960 )
2017
4
A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease. ( 27127318 )
2016
5
Polycystic ovarian disease and associated factors. ( 27075885 )
2016
6
Involvement of Matrix Metalloproteinases and their Inhibitors in Bovine Cystic Ovarian Disease. ( 27993358 )
2016
7
Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary. ( 26677854 )
2016
8
Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials. ( 26657509 )
2016
9
Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease. ( 27834809 )
2016
10
BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development. ( 27486268 )
2016
11
Molecular aspects of bovine cystic ovarian disease pathogenesis. ( 25767139 )
2015
12
Authors' reply to: "Empiric" inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. ( 25687660 )
2015
13
Oral contraceptive pills induced hemichorea in an adolescent female with polycystic ovarian disease. ( 25878392 )
2015
14
Altered Expression of Pro-inflammatory Cytokines in Ovarian Follicles of Cows with Cystic Ovarian Disease. ( 26065705 )
2015
15
A novel serum microRNA panel to discriminate benign from malignant ovarian disease. ( 25451316 )
2015
16
"Empiric" inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. ( 25687659 )
2015
17
Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease. ( 25813700 )
2015
18
Involvement of PAPP-A and IGFR1 in Cystic Ovarian Disease in Cattle. ( 26031184 )
2015
19
Women with clomiphene citrate resistant polycystic ovarian disease: predictors of spontaneous ovulation after laparoscopic ovarian drilling. ( 24576485 )
2014
20
Polycystic ovarian disease: still an enigma! ( 24685855 )
2014
21
Epidemiological description of cystic ovarian disease in argentine dairy herds: risk factors and effects on the reproductive performance of lactating cows. ( 25292292 )
2014
22
GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats. ( 25263979 )
2014
23
Altered expression of transforming growth factor-beta isoforms in bovine cystic ovarian disease. ( 25112788 )
2014
24
Can treatment for polycystic ovarian disease induce ovarian tumour? A case report. ( 24596770 )
2014
25
Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease. ( 25001504 )
2014
26
Interaction between IGF1 and IGFBPs in bovine cystic ovarian disease. ( 23693122 )
2013
27
Ovarian localization of 11I^-hydroxysteroid dehydrogenase (11I^HSD): effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. ( 23972491 )
2013
28
Cutting edge: Ly49C/Ia8> neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. ( 23960238 )
2013
29
Adrenal ganglioneuroma in a patient with polycystic ovarian disease (PCOD): a rare association. ( 24145507 )
2013
30
Assisted reproduction in polycystic ovarian disease: A multicentric trial in India. ( 23869152 )
2013
31
Changes in the expression of Heat Shock Proteins in ovaries from bovines with cystic ovarian disease induced by ACTH. ( 23937990 )
2013
32
Effect of shatapushpa taila matra basti and pathadi kwatha on poly cystic ovarian disease. ( 23559797 )
2012
33
Environmentally induced epigenetic transgenerational inheritance of ovarian disease. ( 22570695 )
2012
34
Steroid receptor mRNA expression in the ovarian follicles of cows with cystic ovarian disease. ( 21536311 )
2012
35
Extremely elevated CA-125 in benign ovarian disease due to stretch of the peritoneum. ( 23188839 )
2012
36
Tolerogenic DNA vaccine for prevention of autoimmune ovarian disease. ( 22221010 )
2012
37
Environmental toxicants induce ovarian disease across generations. ( 23275984 )
2012
38
Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: a career retrospective. ( 22028409 )
2012
39
Doppler imaging in the diagnosis of ovarian disease. ( 23480621 )
2012
40
Management of ovarian disease in pregnancy. ( 22115171 )
2011
41
Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle. ( 21940120 )
2011
42
A case of successful treatment of comorbid obesity and polycystic ovarian disease with add-on metformin in bipolar disorder. ( 22295263 )
2011
43
Risk factors associated with cystic ovarian disease in Norwegian dairy cattle. ( 21059258 )
2010
44
Surgical management of ovarian disease in infants, children, and adolescents: a 15-year review. ( 20059326 )
2010
45
Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. ( 20800980 )
2010
46
A prospective randomized trial comparing the clinical and endocrinological outcome with rosiglitazone versus laparoscopic ovarian drilling in patients with polycystic ovarian disease resistant to ovulation induction with clomiphene citrate. ( 19956961 )
2010
47
Heat shock protein patterns in the bovine ovary and relation with cystic ovarian disease. ( 19744807 )
2010
48
Insulin-like growth factor-II and insulin-like growth factor-binding proteins in bovine cystic ovarian disease. ( 19959179 )
2010
49
Leptin concentrations in the peritoneal fluid of women with ovarian endometriosis are different according to the presence of a 'deep' or 'superficial' ovarian disease. ( 19544117 )
2009
50
Prospective identification and characterization of ovarian cancer stem cells: Implications for the treatment of chemotherapy resistant/recurrent ovarian disease. ( 19158501 )
2009

Variations for Ovarian Disease

Expression for Ovarian Disease

Search GEO for disease gene expression data for Ovarian Disease.

Pathways for Ovarian Disease

GO Terms for Ovarian Disease

Cellular components related to Ovarian Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 AMH BMP15 GDF9 GNRH1 IGF1 IGFBP1
2 extracellular region GO:0005576 9.47 AMH BMP15 CGA GDF9 GNRH1 IGF1
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Ovarian Disease according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.87 AMH CGA GNRH1 INS
2 cellular protein metabolic process GO:0044267 9.77 BMP15 IGF1 IGFBP1 INS PRL
3 BMP signaling pathway GO:0030509 9.71 AMH BMP15 GDF9
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 FSHR IGF1 INS
5 binding of sperm to zona pellucida GO:0007339 9.63 ZP1 ZP3 ZP4
6 female gonad development GO:0008585 9.58 CYP19A1 FOXL2 FSHR
7 positive regulation of glycolytic process GO:0045821 9.56 IGF1 INS
8 single fertilization GO:0007338 9.56 FOXL2 ZP1 ZP3 ZP4
9 positive regulation of glycogen biosynthetic process GO:0045725 9.55 IGF1 INS
10 positive regulation of acrosome reaction GO:2000344 9.52 ZP3 ZP4
11 female gamete generation GO:0007292 9.5 BMP15 FSHR GDF9
12 positive regulation of humoral immune response GO:0002922 9.49 ZP3 ZP4
13 negative regulation of binding of sperm to zona pellucida GO:2000360 9.48 ZP3 ZP4
14 oocyte growth GO:0001555 9.43 FOXL2 GDF9
15 uterus development GO:0060065 9.33 CYP19A1 FOXL2 FSHR
16 gonad development GO:0008406 9.13 AMH CGA FSHR
17 regulation of MAPK cascade GO:0043408 8.92 BMP15 FSHR GDF9 REN

Molecular functions related to Ovarian Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 AMH BMP15 GDF9 IGF1
2 transforming growth factor beta receptor binding GO:0005160 9.33 AMH BMP15 GDF9
3 acrosin binding GO:0032190 9.26 ZP3 ZP4
4 insulin-like growth factor receptor binding GO:0005159 9.13 IGF1 INS REN
5 hormone activity GO:0005179 9.1 AMH CGA GNRH1 IGF1 INS PRL

Sources for Ovarian Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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