MCID: OVR051
MIFTS: 36

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 14
Endodermal Sinus Tumor of Ovary 12 69
Ovarian Yolk Sac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 47 C8107
SNOMED-CT 64 254876005
UMLS 69 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to glandular pattern ovarian yolk sac tumor and hepatoid pattern ovarian yolk sac tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 glandular pattern ovarian yolk sac tumor 12.2
2 hepatoid pattern ovarian yolk sac tumor 12.2
3 polyvesicular vitelline pattern ovarian yolk sac tumor 12.2
4 childhood ovarian endodermal sinus tumor 12.1
5 clear cell variant infiltrating bladder urothelial carcinoma 10.7 AFP SERPINA1
6 polymyositis 10.7 AFP SERPINA1
7 mature teratoma 10.7 AFP SALL4
8 mediastinal mesenchymal tumor 10.6 AFP GPC3
9 visual cortex disease 10.6 AFP GPC3
10 diabetes mellitus, insulin-dependent, 20 10.6 AFP GPC3
11 rete ovarii cystadenofibroma 10.6 AFP SERPINA1
12 endodermal sinus tumor 10.5
13 anterolateral myocardial infarction 10.5 AFP SALL4
14 tricuspid valve insufficiency 10.5 AFP SERPINA1
15 eccrine acrospiroma 10.5 AFP KRT7
16 ovarian mucinous cystadenocarcinoma 10.5 GPC3 SALL4
17 orbital granuloma 10.5 MSX2 SALL4
18 clear cell squamous cell skin carcinoma 10.5 AFP KRT7
19 testicular trophoblastic tumor 10.4 AFP KRT7
20 breast secretory carcinoma 10.4 AFP KRT7
21 testicular germ cell cancer 10.4 AFP KRT7
22 sex differentiation disease 10.4 AFP SALL4 SERPINA1
23 malignant peritoneal solitary fibrous tumor 10.4 AFP KRT7
24 colon signet ring adenocarcinoma 10.3 AFP SERPINA1
25 status asthmaticus 10.3 GPC3 SERPINA1
26 group b strep disease in newborns 10.2 KRT7 SERPINA1
27 kidney clear cell sarcoma 10.2 EZH2 KRT7
28 lymphedema 10.2 AFP GPC3 SERPINA1
29 mediastinum synovial sarcoma 10.1 AFP KRT7 SERPINA1
30 cerebellar vermis medulloblastoma 10.1 AFP GPC3 KRT7
31 ectodermal dysplasia with natal teeth, turnpenny type 10.1 AFP GPC3 KRT7
32 apocrine adenocarcinoma 10.1 AFP GPC3 KRT7
33 gallbladder cancer 10.1 AFP GPC3 KRT7
34 skin tag 10.1 AFP GPC3 KRT7
35 uterine corpus apoplectic leiomyoma 10.0 EZH2 KRT7
36 perivascular epithelioid cell tumor 10.0 KRT7 SALL4
37 sleep disorder 10.0 AFP GPC3 SALL4 SERPINA1
38 peritoneal serous adenocarcinoma 10.0 AFP KRT7
39 microcystic meningioma 10.0 KRT7 SERPINA1
40 thoracic outlet syndrome 9.8 AFP KRT7
41 focal epithelial hyperplasia 5.5 AFP EZH2 GPC3 GSTA1 HLX HOXB7
42 pulmonary coin lesion 5.5 AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
2 endocrine/exocrine gland MP:0005379 9.56 AFP EZH2 HLX HOXB7 KPNA1 MSX2
3 hematopoietic system MP:0005397 9.23 HOXB7 KPNA1 MSX2 NKX2-5 SIRT1 EZH2

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
4
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Captopril Approved Phase 3 62571-86-2 44093
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Fluconazole Approved Phase 3 86386-73-4 3365
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
11
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
12
Bleomycin Approved Phase 3 11056-06-7 5360373
13
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
14 Antibodies Phase 3,Phase 1
15 Antibodies, Monoclonal Phase 3,Phase 1
16 Anti-Infective Agents Phase 3,Phase 2
17 Antimetabolites Phase 3
18 Antiviral Agents Phase 3,Phase 2
19 Immunoglobulins Phase 3,Phase 1
20 Anti-Bacterial Agents Phase 3
21 Antifungal Agents Phase 3
22 Antiparasitic Agents Phase 3
23 Antiprotozoal Agents Phase 3
24 Echinocandins Phase 3
25 Liposomal amphotericin B Phase 3
26 Alkylating Agents Phase 3,Phase 2
27 Angiotensin-Converting Enzyme Inhibitors Phase 3
28 Antihypertensive Agents Phase 3
29 Antirheumatic Agents Phase 3
30 HIV Protease Inhibitors Phase 3
31 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
32
protease inhibitors Phase 3
33 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
34 Cytochrome P-450 CYP3A Inhibitors Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Hormone Antagonists Phase 3,Phase 1,Phase 2
37 Hormones Phase 3,Phase 1,Phase 2
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
39 Hydroxyitraconazole Phase 3
40 Steroid Synthesis Inhibitors Phase 3
41 Antimitotic Agents Phase 3,Phase 2,Phase 1
42 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
43 Antibiotics, Antitubercular Phase 3
44 Dermatologic Agents Phase 3
45 Etoposide phosphate Phase 3,Phase 2
46 Keratolytic Agents Phase 3
47 Podophyllotoxin Phase 3 518-28-5
48 Topoisomerase Inhibitors Phase 3,Phase 2
49
Ifosfamide Approved Phase 2 3778-73-2 3690
50
Lenograstim Approved Phase 2 135968-09-1

Interventional clinical trials:

(show all 24)

id Name Status NCT ID Phase Drugs
1 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
2 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
3 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
5 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
7 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3 cisplatin;etoposide
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
9 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
10 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
11 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
12 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
14 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
15 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
16 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
17 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
18 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
19 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
20 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
21 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
22 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
23 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
24 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

39
Ovary, Bone Marrow, Bone, Colon, Brain, Small Intestine

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show all 19)
id Title Authors Year
1
Treatment of ovarian endodermal sinus tumor to preserve fertility. ( 23351423 )
2013
2
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. ( 21058449 )
2010
3
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. ( 18672645 )
2008
4
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. ( 18656249 )
2008
5
Ovarian endodermal sinus tumor in a 76-year-old woman. ( 14641700 )
2003
6
Ovarian endodermal sinus tumor in a postmenopausal woman. ( 11531302 )
2001
7
Management of ovarian endodermal sinus tumor. ( 9208488 )
1996
8
Recurrent ovarian endodermal sinus tumor: demonstration by computed tomography, magnetic resonance imaging, and positron emission tomography. ( 8542908 )
1995
9
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 1541445 )
1992
10
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 2050306 )
1991
11
Intestinal variant of ovarian endodermal sinus tumor. ( 2470657 )
1989
12
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 3169625 )
1988
13
Delivery following removal and chemotherapy of ovarian endodermal sinus tumor. ( 3632459 )
1987
14
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 2430863 )
1986
15
Ovarian endodermal sinus tumor with intestinal differentiation. ( 2418946 )
1986
16
A case of ovarian endodermal sinus tumor associated with pregnancy. ( 6719453 )
1984
17
Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. ( 6208090 )
1984
18
Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. ( 6198243 )
1984
19
Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. ( 703993 )
1978

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.78 EZH2 MSX2 NKX2-5 SIRT1
2 viral process GO:0016032 9.67 KPNA1 KPNA2 KRT7 SIRT1
3 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.65 EZH2 MSX2 NKX2-5 SALL4 SIRT1
4 positive regulation of BMP signaling pathway GO:0030513 9.46 GPC3 MSX2
5 embryonic hindlimb morphogenesis GO:0035116 9.43 GPC3 MSX2
6 outflow tract septum morphogenesis GO:0003148 9.4 MSX2 NKX2-5
7 NLS-bearing protein import into nucleus GO:0006607 9.32 KPNA1 KPNA2
8 ovulation from ovarian follicle GO:0001542 9.16 AFP SIRT1
9 modulation by virus of host process GO:0019054 8.96 KPNA1 KPNA2
10 regulation of DNA recombination GO:0000018 8.62 KPNA1 KPNA2

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 AFP EZH2 GPC3 HLX HOXB7 KPNA1
2 nuclear localization sequence binding GO:0008139 9.26 KPNA1 KPNA2
3 transcription factor binding GO:0008134 9.26 MSX2 NKX2-5 SALL4 SIRT1
4 sequence-specific DNA binding GO:0043565 9.1 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4

Sources for Ovarian Endodermal Sinus Tumor

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30 HGMD
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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