MCID: OVR051
MIFTS: 34

Ovarian Endodermal Sinus Tumor malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

Aliases & Descriptions for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 14
Endodermal Sinus Tumor of Ovary 12 69
Ovarian Yolk Sac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 47 C8107
SNOMED-CT 64 254876005
UMLS 69 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to glandular pattern ovarian yolk sac tumor and hepatoid pattern ovarian yolk sac tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 glandular pattern ovarian yolk sac tumor 12.2
2 hepatoid pattern ovarian yolk sac tumor 12.1
3 polyvesicular vitelline pattern ovarian yolk sac tumor 12.1
4 childhood ovarian endodermal sinus tumor 12.1
5 endodermal sinus tumor 10.5
6 rete testis adenoma 10.3 AFP SERPINA1
7 pontine hemorrhage 10.3 AFP SERPINA1
8 adult teratoma 10.2 AFP GPC3
9 uterine corpus serous adenocarcinoma 10.2 AFP GPC3
10 pediatric liposarcoma 10.2 AFP GPC3
11 diabetes mellitus, noninsulin-dependent, 2 10.2 AFP GPC3
12 testicular gonadoblastoma 10.2 SLC13A2 SLC13A5
13 eccrine papillary adenoma 10.2 AFP KRT7
14 adult botryoid rhabdomyosarcoma 10.1 AFP SERPINA1
15 nonossifying fibromyxoid tumor 10.1 AFP KRT7
16 malignant teratocarcinosarcoma 10.1 AFP KPNA2
17 trophoblastic neoplasm 10.1 AFP KRT7
18 cellular ependymoma 10.0 AFP KRT7 SERPINA1
19 focal epithelial hyperplasia 10.0 AFP GPC3 SALL4 SERPINA1
20 medullomyoblastoma 10.0 AFP GPC3 KRT7
21 basophilic carcinoma 10.0 AFP GPC3 KRT7
22 odontotrichoungual-digital-palmar syndrome 10.0 AFP GPC3 KRT7
23 malignant ovarian mixed epithelial neoplasm 10.0 AFP GPC3 KRT7
24 gastroesophageal junction adenocarcinoma 10.0 AFP GPC3 KRT7
25 klatskin's tumor 10.0 AFP KRT7
26 proctitis 10.0 AFP GPC3 KRT7
27 klinefelter's syndrome 9.9 AFP GPC3 HLX SALL4 SERPINA1
28 malignant teratoma 9.9 AFP KRT7
29 middle ear adenocarcinoma 9.8 EZH2 KRT7
30 retroperitoneal hemangiopericytoma 8.1 AFP EZH2 GPC3 GSTA1 HLX HOXB7
31 hair follicle neoplasm 8.1 AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 SALL4 SIRT1 GPC3 HLX MSX2 NKX2-5
2 endocrine/exocrine gland MP:0005379 9.56 AFP EZH2 HLX HOXB7 KPNA1 MSX2
3 homeostasis/metabolism MP:0005376 9.32 AFP EZH2 GPC3 HLX KPNA1 KRT7

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 1,Phase 2 15663-27-1 84093 441203 2767
2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Captopril Approved Phase 3 62571-86-2 44093
6
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
7
Ribavirin Approved Phase 3 36791-04-5 37542
8
Fluconazole Approved Phase 3 86386-73-4 3365
9
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11
Palivizumab Approved, Investigational Phase 3 188039-54-5
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
13
Succinylcholine Approved Phase 3 306-40-1 5314
14
Bleomycin Approved Phase 3 11056-06-7 5360373
15 Alkylating Agents Phase 3,Phase 1,Phase 2
16 Anti-Infective Agents Phase 3,Phase 1,Phase 2
17 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
18 Antimetabolites Phase 3,Phase 1,Phase 2
19 Antimitotic Agents Phase 3,Phase 1,Phase 2
20 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
21 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
22 Antiviral Agents Phase 3,Phase 1,Phase 2
23 Hydroxyitraconazole Phase 3
24
protease inhibitors Phase 3
25 Steroid Synthesis Inhibitors Phase 3
26 HIV Protease Inhibitors Phase 3
27 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
28 Cytochrome P-450 CYP3A Inhibitors Phase 3
29 Cytochrome P-450 Enzyme Inhibitors Phase 3
30 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
31 Hormone Antagonists Phase 3,Phase 1,Phase 2
32 Hormones Phase 3,Phase 1,Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
34 Echinocandins Phase 3
35 Angiotensin-Converting Enzyme Inhibitors Phase 3
36 Anti-Bacterial Agents Phase 3
37 Etoposide phosphate Phase 3,Phase 2,Phase 1
38 Immunoglobulins Phase 3,Phase 1
39 Antibodies, Monoclonal Phase 3,Phase 1
40 Antifungal Agents Phase 3
41 Antihypertensive Agents Phase 3
42 Liposomal amphotericin B Phase 3
43 Antibodies Phase 3,Phase 1
44 Antirheumatic Agents Phase 3
45 Antiparasitic Agents Phase 3
46 Antiprotozoal Agents Phase 3
47 Podophyllotoxin Phase 3 518-28-5
48 Neuromuscular Agents Phase 3
49 Neuromuscular Blocking Agents Phase 3
50 Neuromuscular Depolarizing Agents Phase 3

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
2 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
3 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
4 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
5 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
6 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3
7 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3
8 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2
9 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2
11 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2
12 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
14 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
17 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2
18 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2
19 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2
20 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
21 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1
22 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
23 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1
24 Biological Therapy in Treating Patients With Metastatic Cancer Completed NCT00004604 Phase 1
25 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
26 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
27 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
28 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
29 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

39
Ovary

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show all 19)
id Title Authors Year
1
Treatment of ovarian endodermal sinus tumor to preserve fertility. ( 23351423 )
2013
2
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. ( 21058449 )
2010
3
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. ( 18656249 )
2008
4
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. ( 18672645 )
2008
5
Ovarian endodermal sinus tumor in a 76-year-old woman. ( 14641700 )
2003
6
Ovarian endodermal sinus tumor in a postmenopausal woman. ( 11531302 )
2001
7
Management of ovarian endodermal sinus tumor. ( 9208488 )
1996
8
Recurrent ovarian endodermal sinus tumor: demonstration by computed tomography, magnetic resonance imaging, and positron emission tomography. ( 8542908 )
1995
9
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 1541445 )
1992
10
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 2050306 )
1991
11
Intestinal variant of ovarian endodermal sinus tumor. ( 2470657 )
1989
12
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 3169625 )
1988
13
Delivery following removal and chemotherapy of ovarian endodermal sinus tumor. ( 3632459 )
1987
14
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 2430863 )
1986
15
Ovarian endodermal sinus tumor with intestinal differentiation. ( 2418946 )
1986
16
A case of ovarian endodermal sinus tumor associated with pregnancy. ( 6719453 )
1984
17
Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. ( 6198243 )
1984
18
Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. ( 6208090 )
1984
19
Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. ( 703993 )
1978

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.73 KPNA1 KPNA2 KRT7 SIRT1
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.65 EZH2 MSX2 NKX2-5 SALL4 SIRT1
3 embryonic hindlimb morphogenesis GO:0035116 9.4 GPC3 MSX2
4 outflow tract septum morphogenesis GO:0003148 9.37 MSX2 NKX2-5
5 NLS-bearing protein import into nucleus GO:0006607 9.32 KPNA1 KPNA2
6 ovulation from ovarian follicle GO:0001542 9.16 AFP SIRT1
7 modulation by virus of host process GO:0019054 8.96 KPNA1 KPNA2
8 regulation of DNA recombination GO:0000018 8.62 KPNA1 KPNA2

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 MSX2 NKX2-5 SALL4 SIRT1
2 nuclear localization sequence binding GO:0008139 9.16 KPNA1 KPNA2
3 sequence-specific DNA binding GO:0043565 9.1 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4

Sources for Ovarian Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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