MCID: OVR051
MIFTS: 38

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 14
Endodermal Sinus Tumor of Ovary 12 69
Ovarian Yolk Sac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 46 C8107
SNOMED-CT 64 254876005
UMLS 69 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to endodermal sinus tumor and glandular pattern ovarian yolk sac tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.9 AFP KRT7 SALL4 SERPINA1
2 glandular pattern ovarian yolk sac tumor 12.3
3 hepatoid pattern ovarian yolk sac tumor 12.3
4 polyvesicular vitelline pattern ovarian yolk sac tumor 12.3
5 childhood ovarian endodermal sinus tumor 12.3
6 intrahepatic bile duct adenoma 10.5 AFP KRT7
7 malignant teratoma 10.4 AFP SALL4
8 mucinous cystadenofibroma 10.4 AFP SERPINA1
9 polyembryoma 10.4 AFP SERPINA1
10 bile duct cystadenocarcinoma 10.4 AFP KRT7
11 intratubular embryonal carcinoma 10.4 AFP KRT7
12 renal pelvis carcinoma 10.4 AFP KRT7
13 choriocarcinoma of the testis 10.4 AFP KRT7
14 testicular malignant germ cell cancer 10.4 AFP GPC3
15 epithelioid trophoblastic tumor 10.4 KRT7 SALL4
16 ovarian embryonal carcinoma 10.4 AFP GPC3
17 adenomatoid tumor 10.4 AFP KRT7
18 hepatic adenomas, familial 10.4 AFP GPC3
19 pancreatoblastoma 10.4 AFP SERPINA1
20 sertoli-leydig cell tumor 10.3 AFP KRT7
21 malignant biphasic mesothelioma 10.3 AFP KRT7
22 extragonadal seminoma 10.3 AFP SALL4
23 pancreatic cystadenocarcinoma 10.3 AFP SERPINA1
24 placental site trophoblastic tumor 10.3 GPC3 SALL4
25 horner's syndrome 10.3 GPC3 KRT7
26 inverted papilloma 10.2 KRT7 MSX2
27 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 GPC3 SERPINA1
28 alpha-fetoprotein deficiency 10.2
29 cystadenofibroma 10.2 AFP KRT7 SERPINA1
30 acinar cell carcinoma 10.2 AFP KRT7 SERPINA1
31 granulosa cell tumor of the ovary 10.2 KRT7 SERPINA1
32 seminal vesicle tumor 10.2 AFP GPC3 KRT7
33 bile duct adenocarcinoma 10.2 AFP GPC3 KRT7
34 intrahepatic cholangiocarcinoma 10.1 AFP GPC3 KRT7
35 gastrointestinal system cancer 10.1 AFP GPC3 KRT7
36 hepatoblastoma 10.1 AFP GPC3 KRT7
37 cholangiocarcinoma 10.1 AFP GPC3 KRT7
38 malignant germ cell tumor 10.1 AFP KPNA2
39 pancreatic mucinous cystadenoma 10.1 EZH2 KRT7
40 ovarian germ cell cancer 10.1 AFP HLX KRT7 SALL4
41 carotid artery dissection 10.1 GPC3 SERPINA1
42 liver cirrhosis 10.0 AFP GPC3 SERPINA1
43 benign mesothelioma 10.0 GPC3 KRT7
44 secretory meningioma 10.0 KRT7 SERPINA1
45 germ cell and embryonal cancer 9.9 AFP KRT7
46 testicular yolk sac tumor 9.9 AFP GPC3 SALL4 SERPINA1
47 hepatocellular carcinoma 9.5 AFP GPC3 GSTA1 KRT7 SERPINA1
48 ovarian primitive germ cell tumor 6.6 AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
2 endocrine/exocrine gland MP:0005379 9.56 AFP EZH2 HLX HOXB7 KPNA1 MSX2
3 hematopoietic system MP:0005397 9.23 EZH2 GPC3 HLX HOXB7 KPNA1 MSX2

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
3
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Captopril Approved Phase 3 62571-86-2 44093
6
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
7
Ribavirin Approved Phase 3 36791-04-5 37542
8
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
9
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
10
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
11
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
14 Hydroxyitraconazole Phase 3
15 Alkylating Agents Phase 3,Phase 2
16
protease inhibitors Phase 3
17 Steroid Synthesis Inhibitors Phase 3
18 Topoisomerase Inhibitors Phase 3
19 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 3
21 HIV Protease Inhibitors Phase 3
22 Cytochrome P-450 Enzyme Inhibitors Phase 3
23 Hormone Antagonists Phase 3,Phase 1,Phase 2
24 Hormones Phase 3,Phase 1,Phase 2
25 Angiotensin-Converting Enzyme Inhibitors Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
27 Echinocandins Phase 3
28 Antibodies, Monoclonal Phase 3,Phase 1
29 Anti-Bacterial Agents Phase 3
30 Anti-Infective Agents Phase 3,Phase 2
31 Antifungal Agents Phase 3
32 Immunoglobulins Phase 3,Phase 1
33 Antihypertensive Agents Phase 3
34 Etoposide phosphate Phase 3
35 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
36 Antimetabolites Phase 3
37 Antimitotic Agents Phase 3,Phase 2,Phase 1
38 Antibiotics, Antitubercular Phase 3
39 Liposomal amphotericin B Phase 3
40 Antibodies Phase 3,Phase 1
41 Antiprotozoal Agents Phase 3
42 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
43 Antiparasitic Agents Phase 3
44 Antirheumatic Agents Phase 3
45 Antiviral Agents Phase 3,Phase 2
46 Podophyllotoxin Phase 3 518-28-5
47 Dermatologic Agents Phase 3
48 Keratolytic Agents Phase 3
49
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
50
Ifosfamide Approved Phase 2 3778-73-2 3690

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
20 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
21 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
22 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

38
Ovary, Bone Marrow, Bone, Breast, Brain, Colon, Small Intestine

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show all 19)
# Title Authors Year
1
Treatment of ovarian endodermal sinus tumor to preserve fertility. ( 23351423 )
2013
2
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. ( 21058449 )
2010
3
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. ( 18656249 )
2008
4
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. ( 18672645 )
2008
5
Ovarian endodermal sinus tumor in a 76-year-old woman. ( 14641700 )
2003
6
Ovarian endodermal sinus tumor in a postmenopausal woman. ( 11531302 )
2001
7
Management of ovarian endodermal sinus tumor. ( 9208488 )
1996
8
Recurrent ovarian endodermal sinus tumor: demonstration by computed tomography, magnetic resonance imaging, and positron emission tomography. ( 8542908 )
1995
9
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 1541445 )
1992
10
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 2050306 )
1991
11
Intestinal variant of ovarian endodermal sinus tumor. ( 2470657 )
1989
12
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 3169625 )
1988
13
Delivery following removal and chemotherapy of ovarian endodermal sinus tumor. ( 3632459 )
1987
14
Ovarian endodermal sinus tumor with intestinal differentiation. ( 2418946 )
1986
15
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 2430863 )
1986
16
A case of ovarian endodermal sinus tumor associated with pregnancy. ( 6719453 )
1984
17
Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. ( 6198243 )
1984
18
Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. ( 6208090 )
1984
19
Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. ( 703993 )
1978

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.78 EZH2 MSX2 NKX2-5 SIRT1
2 viral process GO:0016032 9.67 KPNA1 KPNA2 KRT7 SIRT1
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.65 EZH2 MSX2 NKX2-5 SALL4 SIRT1
4 positive regulation of BMP signaling pathway GO:0030513 9.46 GPC3 MSX2
5 embryonic hindlimb morphogenesis GO:0035116 9.43 GPC3 MSX2
6 outflow tract septum morphogenesis GO:0003148 9.4 MSX2 NKX2-5
7 NLS-bearing protein import into nucleus GO:0006607 9.32 KPNA1 KPNA2
8 ovulation from ovarian follicle GO:0001542 9.16 AFP SIRT1
9 modulation by virus of host process GO:0019054 8.96 KPNA1 KPNA2
10 regulation of DNA recombination GO:0000018 8.62 KPNA1 KPNA2

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.46 MSX2 NKX2-5 SALL4 SIRT1
2 nuclear localization sequence binding GO:0008139 9.32 KPNA1 KPNA2
3 transcription regulatory region DNA binding GO:0044212 9.26 EZH2 MSX2 NKX2-5 SALL4
4 sequence-specific DNA binding GO:0043565 9.1 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
5 protein binding GO:0005515 10.07 AFP EZH2 GPC3 HLX HOXB7 KPNA1

Sources for Ovarian Endodermal Sinus Tumor

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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70 UMLS via Orphanet
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