MCID: OVR006
MIFTS: 41

Ovarian Endometriosis malady

Reproductive diseases category
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Summaries for Ovarian Endometriosis

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34MalaCards
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MalaCards: Ovarian Endometriosis, also known as endometriosis of ovary, is related to endometriosis and ovarian cancer. An important gene associated with Ovarian Endometriosis is ARSH (arylsulfatase family, member H), and among its related pathways are Signaling by NODAL and Steroid hormone biosynthesis. The compounds androstanedione and hydroxysteroid have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and uterus, and related mouse phenotypes are normal and mortality/aging.

Aliases & Classifications for Ovarian Endometriosis

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9Disease Ontology, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

ovarian endometriosis 9 11
endometriosis of ovary 63


External Ids:

Disease Ontology9 DOID:11426

Related Diseases for Ovarian Endometriosis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Ovarian Endometriosis:



Diseases related to ovarian endometriosis

Symptoms for Ovarian Endometriosis

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Drugs & Therapeutics for Ovarian Endometriosis

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43NIH Clinical Center, 7ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Ovarian Endometriosis

Genetic Tests for Ovarian Endometriosis

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Anatomical Context for Ovarian Endometriosis

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34MalaCards
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MalaCards organs/tissues related to Ovarian Endometriosis:

34
Ovary, Endothelial, Uterus, Cervix, Liver, Smooth muscle, Cortex

Animal Models for Ovarian Endometriosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Endometriosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.8INHA, ESR2, DNMT3L, NODAL, TDGF1
2MP:00107687.3TDGF1, NODAL, GAS6, DNMT3L, ESR2, INHA
3MP:00053857.2TDGF1, NODAL, GAS6, DNMT3L, ESR2, INHA

Publications for Ovarian Endometriosis

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53PubMed
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Articles related to Ovarian Endometriosis:

(show top 50)    (show all 164)
idTitleAuthorsYear
1
Tubal origin of ovarian endometriosis. (24390223)
2014
2
MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis. (23945042)
2013
3
High-resolution array-comparative genomic hybridization profiling reveals 20q13.33 alterations associated with ovarian endometriosis. (23656391)
2013
4
The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. (22633261)
2012
5
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis. (21944080)
2012
6
Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis. (21130491)
2011
7
Involvement of estrogen receptor-related receptors in human ovarian endometriosis. (21561608)
2011
8
Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium. (20155281)
2010
9
A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis. (20221659)
2010
10
Differences in the blood serum levels of soluble HLA-G concentrations between the menstrual cycle phases and menopause in patients with ovarian endometriosis and uterine leiomyoma. (19300397)
2009
11
Risk factors for deep endometriosis: a comparison with pelvic and ovarian endometriosis. (18023442)
2008
12
Relationship between microvascular density and expression of vascular endothelial growth factor in patients with ovarian endometriosis. (18479230)
2008
13
Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual association. (18258232)
2008
14
Ovarian endometriosis associated with ovarian cancer and endometrial-endocervical polyps. (17578358)
2007
15
Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis. (17296189)
2007
16
Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. (17454161)
2007
17
Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis. (16815388)
2006
18
Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis. (16884363)
2006
19
Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis. (15782073)
2005
20
Observation of epithelial atypia associated with intranuclear inclusions in ovarian endometriosis. (15192971)
2004
21
Low-grade endometrial stromal sarcoma with glandular differentiation arising in ovarian endometriosis. (15369960)
2004
22
Increased vascular surface density in ovarian endometriosis. (12737676)
2003
23
Uterus didelphys with cervical agenesis associated with adenomyosis, a leiomyoma and ovarian endometriosis. A case report. (12497685)
2002
24
Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis disseminata, and endometrial adenocarcinoma: an unusual, pathogenetically related association. (11444203)
2001
25
Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis. (11172841)
2001
26
Recurrence of ovarian endometriosis and anatomical location of the primary lesion. (11163828)
2001
27
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis. (11516810)
2001
28
Predictive value of ovarian endometriosis? (10685555)
2000
29
Ovarian endometriosis associated with ovarian carcinoma: a clinicopathological and immunohistochemical study. (10785482)
2000
30
Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. (10611191)
2000
31
Characterization of messenger RNA expression of estrogen receptor-alpha and -beta in patients with ovarian endometriosis. (10856486)
2000
32
Expression of size-polymorphic androgen receptor (AR) gene in ovarian endometriosis according to the number of cytosine, adenine, and guanine (CAG) repeats in AR alleles. (10493597)
1999
33
A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels. (9935115)
1999
34
Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease. (10439002)
1999
35
Gn-RH agonists and ovarian endometriosis. (9720831)
1998
36
Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis. (9389825)
1997
37
Prevalence of ovarian endometriosis in epithelial ovarian cancer. (9486515)
1997
38
Scoring system for prediction of ovarian endometriosis based on transvaginal color and pulsed Doppler sonography. (8005309)
1994
39
Reliability of the visual diagnosis of ovarian endometriosis? (1624016)
1992
40
Reliability of the visual diagnosis of ovarian endometriosis. (1743347)
1991
41
Effect of ovarian endometriosis on ovulation in rabbits. (2912100)
1989
42
Anatomopathologic aspects of ovarian endometriosis. (3359644)
1988
43
Histologic study of ovarian endometriosis after hormonal therapy. (3125069)
1988
44
A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. (424103)
1979
45
Squamous cell carcinoma arising in ovarian endometriosis. (669446)
1978
46
Malignant transformation in ovarian endometriosis. (4823686)
1974
47
Carcinomatous change in ovarian endometriosis. (5042438)
1972
48
Malignant transformation of ovarian endometriosis. Nature, treatment and report of two cases. (5451141)
1970
49
OBSERVATIONS ON METAPLASTIC CHANGES IN THE GERMINAL EPITHELIUM OF THE OVARY AND ON THE AETIOLOGY OF OVARIAN ENDOMETRIOSIS. (14299344)
1965
50
Conservative surgery in ovarian endometriosis. (13007434)
1953

Variations for Ovarian Endometriosis

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Expression for genes affiliated with Ovarian Endometriosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Endometriosis

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Pathways for genes affiliated with Ovarian Endometriosis

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 58SinoBiological, 52PharmGKB, 54QIAGEN
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Compounds for genes affiliated with Ovarian Endometriosis

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Ovarian Endometriosis according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1androstanedione46 25 1211.9AKR1C2, HSD17B1
2hydroxysteroid469.8HSD17B1, AKR1C2
3isoflavone469.8ARSH, ESR2
4bisphenol a469.8ARSH, ESR2
5daidzein469.8ARSH, ESR2
6steroidal469.7ARSH, ESR2
7estriol30 25 1211.7ESR2, HSD17B1
8progestins469.7ARSH, ESR2
95alpha-androstane-3alpha,17beta-diol469.6ESR2, AKR1C2
10dhea469.5ARSH, ESR2
1117beta-hydroxysteroid469.5ARSH, ESR2, HSD17B1
12estrone46 30 25 1212.5ARSH, ESR2, HSD17B1
134-hydroxytamoxifen469.4ARSH, ESR2
14nad+469.4AKR1C2, INHA
15warfarin46 52 25 1212.4GAS6, ARSH
16gnrh469.3INHA, ESR2, ARSH
17nadh46 25 1211.3INHA, HSD17B1, AKR1C2
18progestin469.2ARSH, ESR2
19hydrogen46 2510.2ARSH, AKR1C2, INHA
203beta-hydroxysteroid469.2INHA, ESR2, AKR1C2
21androstenedione46 2510.1INHA, ESR2, AKR1C2
22dihydrotestosterone46 30 25 1212.0ARSH, AKR1C2, ESR2, HSD17B1
23estradiol46 25 1211.0ARSH, ESR2, HSD17B1, INHA
24estrogen468.8INHA, HSD17B1, ESR2, ARSH
25progesterone46 30 62 25 1212.5INHA, HSD17B1, ESR2, AKR1C2, ARSH
26testosterone46 62 25 1211.5INHA, HSD17B1, ESR2, AKR1C2, ARSH
27steroid468.5ARSH, AKR1C2, ESR2, HSD17B1, INHA

GO Terms for genes affiliated with Ovarian Endometriosis

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17Gene Ontology
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Biological processes related to Ovarian Endometriosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1placenta developmentGO:0018909.9NODAL, DNMT3L
2steroid metabolic processGO:0082029.7AKR1C2, HSD17B1
3negative regulation of androgen receptor signaling pathwayGO:0607669.7NODAL, ESR2
4ovarian follicle developmentGO:0015419.5INHA, ESR2
5positive regulation of fibroblast proliferationGO:0481469.3TDGF1, GAS6
6positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3NODAL, ESR2
7peptidyl-serine phosphorylationGO:0181059.3GAS6, TDGF1
8positive regulation of protein kinase B signalingGO:0518979.1GAS6, AKR1C2
9neuron migrationGO:0017649.0GAS6, ESR2
10positive regulation of ERK1 and ERK2 cascadeGO:0703748.9NODAL, GAS6

Molecular functions related to Ovarian Endometriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.0TDGF1, NODAL, INHA
2receptor agonist activityGO:0480188.9NODAL, GAS6
3receptor bindingGO:0051028.7TDGF1, GAS6, INHA

Products for genes affiliated with Ovarian Endometriosis

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Sources for Ovarian Endometriosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet