EOC
MCID: OVR094
MIFTS: 46

Ovarian Epithelial Cancer (EOC) malady

Cancer category

Summaries for Ovarian Epithelial Cancer

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33MalaCards
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MalaCards: Ovarian Epithelial Cancer, also known as epithelial ovarian cancer, is related to adenocarcinoma and thrombocytosis. An important gene associated with Ovarian Epithelial Cancer is KLF8 (Kruppel-like factor 8), and among its related pathways are Glycoprotein hormones and Development Endothelin-1/EDNRA signaling. The compounds d-nal,cys,tyr,d-trp,orn,val,cys,nal-nh2 and [125i][tyr4]bombesin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are renal/urinary system and behavior/neurological.

Aliases & Classifications for Ovarian Epithelial Cancer

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

ovarian epithelial cancer 43
epithelial ovarian cancer 43 61
ovarian epithelial carcinoma 43
malignant neoplasm of ovary 61
ovarian cancer, epithelial 43
eoc 43


Related Diseases for Ovarian Epithelial Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ovarian Epithelial Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6NMBR, XIAP, GNRHR, SNCG, AKT2, GRPR
2thrombocytosis10.5
3clear cell adenocarcinoma10.4
4ovarian clear cell adenocarcinoma10.4
5colon cancer, advanced10.4
6peritoneal carcinoma10.4
7primary peritoneal carcinoma10.4
8ovarian wilms' cancer10.3
9wilms tumor10.3
10ovarian cancer, somatic10.3
11somatostatin analog10.3
12ovarian cancer, childhood10.2
13ovarian dysgenesis 310.2
14ovarian endometriosis10.1
15xeroderma pigmentosum10.1
16hyperandrogenism10.1
17hemochromatosis10.1
18sporadic breast cancer10.1
19malignant ovarian cyst10.1
20lactose intolerance10.1
21appendix cancer10.1
22brain cancer10.1
23vascular cancer10.1
24chromosome 6q deletion10.1
25hypoxia10.1
26thromboembolism10.1
27xeroderma pigmentosum, group b10.1
28xeroderma pigmentosum, group c10.1
29cancer progression/metastasis10.1
30breast cancer susceptibility10.1
31xeroderma pigmentosum, group a10.1
32venous thromboembolism10.1
33xeroderma pigmentosum, group g10.1
34germ cell cancer10.1
35borderline ovarian epithelial tumor10.1
36hepatitis10.0HP
37gastrinoma10.0GRP
38colon adenocarcinoma10.0GRP
39obesity10.0GRP, BRS3
40cervical cancer10.0XIAP
41peptic ulcer10.0PTGS1
42polycystic ovary syndrome10.0GNRHR
43glioblastoma multiforme10.0GRP, GRPR, XIAP
44hepatocellular carcinoma10.0GNRHR, XIAP, GRP
45endometriosis10.0GNRHR, HP
46lung small cell carcinoma10.0BRS3, GRPR, GRP, NMBR
47stomach cancer10.0GRPR, CPOX, PTGS1, GRP
48prostate cancer10.0GRP, PTGS1, XIAP, GNRHR, GRPR
49non-small cell lung carcinoma10.0NMBR, GRP, GRPR, BRS3, XIAP
50arthritis10.0PTGS1, HP

Graphical network of the top 20 diseases related to Ovarian Epithelial Cancer:



Diseases related to ovarian epithelial cancer

Clinical Features for Ovarian Epithelial Cancer

Drugs & Therapeutics for Ovarian Epithelial Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Ovarian Epithelial Cancer

Drug clinical trials:

Search ClinicalTrials for Ovarian Epithelial Cancer

Search NIH Clinical Center for Ovarian Epithelial Cancer

Search CenterWatch for Ovarian Epithelial Cancer

Genetic Tests for Ovarian Epithelial Cancer

Anatomical Context for Ovarian Epithelial Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Ovarian Epithelial Cancer:

33
Whole blood, Lymph node, Brain, Lung, Breast, Ovary, Testis, Monocytes, T cells, B cells, Endothelial, Appendix, Testis germ

Animal Models for Ovarian Epithelial Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ovarian Epithelial Cancer

Sources:
51PubMed
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Articles related to Ovarian Epithelial Cancer:

(show top 50)    (show all 902)
idTitleAuthorsYear
1
Is CA72-4 a useful biomarker in differential diagnosis between ovarian endometrioma and epithelial ovarian cancer? (24191126)
2013
2
Recurrent epithelial ovarian cancer and hormone therapy. (24303498)
2013
3
Perioperative and clinical outcomes in the management of epithelial ovarian cancer using a robotic or abdominal approach. (24080421)
2013
4
Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance. (23652306)
2013
5
The impact of pelvic retroperitoneal invasion and distant nodal metastases in epithelial ovarian cancer. (24183480)
2013
6
EZH2 participates in malignant biological behavior of epithelial ovarian cancer through regulating the expression of BRCA1. (24335192)
2013
7
Current Status and Evolution of Preclinical Drug Development Models of Epithelial Ovarian Cancer. (24377084)
2013
8
BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis. (22685580)
2012
9
The epidermal growth factor receptor as a therapeutic target in epithelial ovarian cancer. (22818908)
2012
10
ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cells. (22232246)
2012
11
Fibrillar type I collagen matrices enhance metastasis/invasion of ovarian epithelial cancer via I^1 integrin and PTEN signals. (23013730)
2012
12
Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. (21559368)
2011
13
Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. (21955482)
2011
14
Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFA,B pathway. (21623171)
2011
15
Association of vascular endothelial growth factor gene polymorphisms with susceptibility to epithelial ovarian cancer. (20973260)
2010
16
Significance of preoperative thrombocytosis in epithelial ovarian cancer. (20090223)
2010
17
Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer. (20670949)
2010
18
Characterisation of a multimeric protein complex associated with ERp57 within the nucleus in paclitaxel-sensitive and -resistant epithelial ovarian cancer cells: the involvement of specific conformational states of beta-actin. (20596672)
2010
19
Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. (20049513)
2010
20
E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. (20181230)
2010
21
Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells. (20196847)
2010
22
Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. (20158306)
2010
23
The clinicopathological characteristics of 'triple-negative' epithelial ovarian cancer. (20203223)
2010
24
Patients with a history of epithelial ovarian cancer presenting with a breast and/or axillary mass. (19101713)
2009
25
Correlation of human leukocyte antigen-G (HLA-G) expression and disease progression in epithelial ovarian cancer. (19692629)
2009
26
Correlation of preoperative serum vascular endothelial growth factor level with CA125 level in patients with epithelial ovarian cancer and its prognostic value]. (18366924)
2008
27
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. (18513786)
2008
28
Effect of chemokine CXCL12 and its receptor CXCR4 on proliferation, migration and invasion of epithelial ovarian cancer cells]. (17697603)
2007
29
Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125). (17617155)
2007
30
Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer. (16609037)
2006
31
Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. (16777976)
2006
32
Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. (17107625)
2006
33
Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma. (16126263)
2005
34
RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women. (15670896)
2005
35
Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia. (15774616)
2005
36
Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer. (15734951)
2005
37
Estrogen receptor-positive human epithelial ovarian carcinoma cells respond to the antitumor drug suramin with increased proliferation: possible insight into ER and epidermal growth factor signaling interactions in ovarian cancer. (15350362)
2004
38
Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer. (14645425)
2003
39
Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer. (11821951)
2002
40
Advances in the management of epithelial ovarian cancer. (11499181)
2001
41
The genetic epidemiology of early-onset epithelial ovarian cancer: a population-based study. (10577927)
1999
42
Cyclin D1 overexpression and p53 mutation status in epithelial ovarian cancer. (10205781)
1999
43
Characteristics and growth patterns of human peritoneal mesothelial cells: comparison between advanced epithelial ovarian cancer and non-ovarian cancer sources. (10643588)
1999
44
Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. (9796976)
1998
45
Detection of serum transforming growth factor-alpha in patients of primary epithelial ovarian cancers by enzyme immunoassay. (9299253)
1997
46
Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer. (9307529)
1997
47
Sequential granulocyte colony-stimulating factor increases cisplatin cytotoxicity in human epithelial ovarian cancer cell lines. (8774656)
1996
48
First experience with FGF-3 (INT-2) amplification in women with epithelial ovarian cancer. (8494710)
1993
49
The value of the human milk fat globule membrane antigen HMFG2 in epithelial ovarian cancer monitoring: comparison with CA125. (8494699)
1993
50
Esorubicin in advanced ovarian epithelial cancer. A phase II study of the EORTC Gynecological Cancer Cooperative Group. (3181261)
1988

Genetic Variations for Ovarian Epithelial Cancer

Expression for genes affiliated with Ovarian Epithelial Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Epithelial Cancer

Search GEO for disease gene expression data for Ovarian Epithelial Cancer.

Pathways for genes affiliated with Ovarian Epithelial Cancer

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Ovarian Epithelial Cancer

Sources:
29IUPHAR, 45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1d-nal,cys,tyr,d-trp,orn,val,cys,nal-nh2 2910.7GRPR, NMBR
2[125i][tyr4]bombesin2910.7NMBR, GRPR
3[leu8]-phyllolitorin2910.7NMBR, GRPR
4gastrin releasing peptide (14-27) (human)2910.7GRPR, NMBR
5rhodei-litorin2910.7NMBR, GRPR
6neuromedin b (1-30) (human)2910.7NMBR, GRPR
7estrogen4510.7SNCG, NR2F1, BARD1
8d-nal-cys-tyr-d-trp-lys-val-cys-nal-nh22910.7BRS3, NMBR, GRPR
9[d-phe6,β-ala11,phe13,nle14]bombesin-(6-14)2910.7BRS3, GRPR, NMBR
10bantag-12910.7NMBR, GRPR, BRS3
11pd 1683682910.7NMBR, GRPR
12mk-50462910.7NMBR, GRPR, BRS3
138-aminooctanoic acid4510.7GRPR, GRP
14pge24510.7LHCGR, CPOX, GRP
15neuromedin b29 2411.6GRPR, NMBR
16ranatensin45 2911.6GRPR, GRP, NMBR
17phyllolitorin29 4511.6GRPR, GRP, NMBR
18dexamethasone45 50 29 1113.6GRPR, GRP, XIAP
192-pyrrolinodoxorubicin4510.6GRPR, GRP
20forskolin45 50 1112.6GRPR, GNRHR, LHCGR
21neuromedin b (porcine)6010.6NMBR, BRS3, GRPR, GRP
22cetrorelix45 29 1112.6LHCGR, GRP, GNRHR, GNRH2
23bombesin60 2911.6NMBR, GRP, GRPR, BRS3
24pd 17625260 2911.6BRS3, NMBR, GRP, GRPR
25grp (porcine)6010.6BRS3, GRPR, GRP, NMBR
26grp (human)6010.6NMBR, GRP, GRPR, BRS3
27(+-)-pgf2-alpha4510.6PTGER1, CPOX, PTGS1
28pgd24510.5PTGS1, CPOX, PTGER1
29inositol 1,4,5 trisphosphate4510.5NMBR, GRP, GRPR, GNRHR, LHCGR
30cycloheximide4510.5GNRHR
31estradiol45 11 2412.4CFI, NR2F1, LHCGR, GNRHR, XIAP
32thromboxane45 2411.4CPOX, PTGER1, PTGS1
33actinomycin d4510.4PTGS1, HP, XIAP, CPOX, GRP, GNRHR
34serine4510.4LHCGR, AKT2, HP, GNRHR, PTGS1
35arachidonic acid45 29 11 2413.4HP, CPOX, PTGER1, GRP, GNRHR, PTGS1
36adenylate4510.4HP, GNRHR, PTGER1, GRP, GRPR, LHCGR
37aspirin45 50 29 2413.4CPOX, HP, PTGS1, GRP
38phosphatidylinositol4510.3CPOX, LHCGR, AKT2, GRPR, GRP, XIAP
39gnrh4510.3LHCGR, GRP, GNRH2, GNRHR
40prostaglandin f2alpha4510.3PTGS1, GRP, LHCGR
41alanine4510.3LHCGR, PTGS1, GRP, GRPR, CPOX, GNRHR
4211-deoxy-pge14510.3PTGER1, PTGS1
43agar4510.3XIAP, SNCG, GRP, PTGS1
44arginine4510.3GRP, CPOX, LHCGR, GRPR, GNRHR, BRS3
45vegf4510.2PTGS1, PTGER1, HP, GRP, GRPR, XIAP
46thromboxane a245 2411.1PTGS1, CPOX, PTGER1
47indomethacin45 60 29 1113.1CPOX, PTGS1, GRP, PTGER1
48tyrosine4510.1SNCG, AKT2, GNRHR, XIAP, GNRH2, GRP
49-, methyl ester4510.0GRPR, PTGER1
50calcium45 50 11 2412.8HP, LHCGR, BRS3, XIAP, GNRHR, SNCG

GO Terms for genes affiliated with Ovarian Epithelial Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:04212710.3PTGS1, GRPR, XIAP
2G-protein coupled receptor signaling pathwayGO:0071869.8PTGER1, NMBR, GRPR, GNRHR, LHCGR

Molecular functions related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bombesin receptor activityGO:00494610.2NMBR, GRPR, BRS3

Products for genes affiliated with Ovarian Epithelial Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Epithelial Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet