EOC
MCID: OVR094
MIFTS: 39

Ovarian Epithelial Cancer (EOC) malady

Rare diseases, Cancer diseases categories

Summaries for Ovarian Epithelial Cancer

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34MalaCards
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MalaCards: Ovarian Epithelial Cancer, also known as epithelial ovarian cancer, is related to ovarian cancer and adenocarcinoma. An important gene associated with Ovarian Epithelial Cancer is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Hormone ligand-binding receptors and GPCRs, Other. The compounds goserelin and cetrorelix have been mentioned in the context of this disorder. Affiliated tissues include ovary, t cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Ovarian Epithelial Cancer

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian epithelial cancer 44
epithelial ovarian cancer 44 63
ovarian epithelial carcinoma 44
malignant neoplasm of ovary 63
ovarian cancer, epithelial 44
eoc 44


Related Diseases for Ovarian Epithelial Cancer

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Ovarian Epithelial Cancer:



Diseases related to ovarian epithelial cancer

Symptoms for Ovarian Epithelial Cancer

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Drugs & Therapeutics for Ovarian Epithelial Cancer

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Ovarian Epithelial Cancer

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Genetic Tests for Ovarian Epithelial Cancer

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Anatomical Context for Ovarian Epithelial Cancer

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34MalaCards
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MalaCards organs/tissues related to Ovarian Epithelial Cancer:

34
Ovary, T cells, Endothelial, Appendix

Animal Models for Ovarian Epithelial Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Epithelial Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2AKT2, PTGS1, GNRHR, LHCGR
2MP:00053898.2AKT2, PTGS1, GNRHR, LHCGR
3MP:00028738.1GRPR, BARD1, NR2F1, AKT2, GNRHR
4MP:00053848.0LHCGR, PTGS1, AKT2, NR2F1, BARD1
5MP:00053787.6LHCGR, GNRHR, PTGS1, AKT2, BARD1
6MP:00053767.4LHCGR, GNRHR, PTGS1, AKT2, GRPR

Publications for Ovarian Epithelial Cancer

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53PubMed
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Articles related to Ovarian Epithelial Cancer:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells. (23254909)
2013
2
Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy. (24133590)
2013
3
Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance. (23652306)
2013
4
Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers. (22985132)
2012
5
Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels. (23189165)
2012
6
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. (22895947)
2012
7
Over-expression of semaphorin4D, hypoxia-inducible factor-1I+ and vascular endothelial growth factor is related to poor prognosis in ovarian epithelial cancer. (23202951)
2012
8
Ovarian epithelial cancer stem cells. (21666993)
2011
9
High-throughput DNA hypermethylation profiling in different ovarian epithelial cancer subtypes using universal bead array. (20811671)
2010
10
Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer. (19945796)
2010
11
Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer. (19181441)
2009
12
Analysis of serum biomarkers of ovarian epithelial cancers based on 2-DE DIGE and MALDI TOF/TOF]. (19173805)
2008
13
Multitargeting ovarian epithelial cancer: adding the old to the new. (18349413)
2008
14
Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. (18676764)
2008
15
Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. (17712227)
2007
16
Two-tier grading system for ovarian epithelial cancer: has its time arrived? (17667555)
2007
17
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. (17943850)
2007
18
Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer. (16936295)
2006
19
Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication. (16961294)
2006
20
Debulking surgery for ovarian epithelial cancer performed by a gynaecological oncologist improved survival compared with less specialised surgeons. (16707225)
2006
21
Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides. (15944801)
2005
22
Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group). (15226774)
2004
23
Borderline ovarian epithelial cancer. (21213507)
2004
24
Oncogenic pathways implicated in ovarian epithelial cancer. (12959183)
2003
25
Expression of aFGF in ovarian epithelial cancer and its signal transduction pathway]. (12899800)
2003
26
Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells. (12626776)
2003
27
Restoration of an impaired TGF-beta1 autocrine growth-inhibitory circuit results in growth inhibition of ovarian epithelial cancer cells and complete inhibition of their tumorigenicity. (14585325)
2003
28
Papanicolaou smears are of little value in the post-treatment surveillance of patients with ovarian epithelial cancer. (17050956)
2001
29
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. (11280739)
2001
30
The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. (10828496)
2000
31
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. (9679957)
1998
32
p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer. (9307189)
1997
33
Fertility drugs and ovarian epithelial cancer: is there a link? (8986583)
1996
34
Comparison of four methods to generate immunoreactive fragments of a murine monoclonal antibody OC859 against human ovarian epithelial cancer antigen. (7647323)
1995
35
Reduction of tumor necrosis factor-alpha bioactivity by a human ovarian epithelial cancer cell line in vitro. (7503187)
1995
36
Is there a role for CT scanning to monitor therapy of optimally debulked patients with advanced ovarian epithelial cancer? (11578380)
1994
37
A new expert system for histopathological diagnosis of human ovarian epithelial cancer. (8218981)
1993
38
Symptoms and diagnostic difficulties in ovarian epithelial cancer. (7901083)
1993
39
Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. (1592292)
1992
40
Human ovarian epithelial cancer cells cultures in vitro express both interleukin 1 alpha and beta genes. (1559228)
1992
41
High-dose, short-duration cisplatin/doxorubicin combination chemotherapy for advanced ovarian epithelial cancer. (1655227)
1991
42
Development of two new monoclonal antibodies reactive to a surface antigen present on human ovarian epithelial cancer cells. (1855217)
1991
43
A phase II trial of intraperitoneal cisplatin and etoposide for primary treatment of ovarian epithelial cancer. (2295904)
1990
44
Carbon dioxide laser vaporization of diaphragmatic metastases for cytoreduction of ovarian epithelial cancer. (2216210)
1990
45
Survival after second-look laparotomy in advanced ovarian epithelial cancer. Study of 86 patients. (2702999)
1989
46
Navelbine in advanced ovarian epithelial cancer: a study of the French oncology centers. (2652318)
1989
47
Involvement of the appendix in ovarian epithelial cancer--an update. (2595505)
1989
48
Esorubicin in advanced ovarian epithelial cancer. A phase II study of the EORTC Gynecological Cancer Cooperative Group. (3181261)
1988
49
Ovarian epithelial cancer and chemical carcinogenesis. (7308865)
1981
50
Lymphangiography in patients with ovarian epithelial cancer: an evaluation of 289 consecutive cases. (561650)
1977

Variations for Ovarian Epithelial Cancer

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Ovarian Epithelial Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
3AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551

Expression for genes affiliated with Ovarian Epithelial Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Epithelial Cancer

Search GEO for disease gene expression data for Ovarian Epithelial Cancer.

Pathways for genes affiliated with Ovarian Epithelial Cancer

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 61Thomson Reuters
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Pathways related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GNRHR, LHCGR
29.3GNRHR, GRPR
3
Show member pathways
Peptide GPCRs39
9.0GRPR, GNRHR, LHCGR
4
Show member pathways
9.0GRPR, GNRHR, LHCGR
5
Show member pathways
8.7PTGS1, GNRHR, LHCGR
6
Show member pathways
8.5GRPR, AKT2, GNRHR, LHCGR

Compounds for genes affiliated with Ovarian Epithelial Cancer

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1goserelin46 30 1211.9GNRHR, LHCGR
2cetrorelix46 30 1211.9GNRHR, LHCGR
3leuprolide acetate469.9LHCGR, GNRHR
4buserelin46 30 1211.9LHCGR, GNRHR
5meloxicam46 1210.7CPOX, PTGS1
6rofecoxib46 52 30 1212.6CPOX, PTGS1
7naproxen46 25 1211.6CPOX, PTGS1
8(+-)-pgf2-alpha469.6CPOX, PTGS1
9pgd2469.6CPOX, PTGS1
10txb2469.6CPOX, PTGS1
11prostaglandin f2alpha469.6LHCGR, PTGS1
12diclofenac46 30 52 1212.6CPOX, PTGS1
13thromboxane46 2510.5CPOX, PTGS1
14ibuprofen46 30 52 25 1213.5CPOX, PTGS1
15salicylic acid46 3010.5CPOX, PTGS1
16celecoxib46 62 30 52 25 1214.5PTGS1, CPOX
17estradiol46 25 1211.4NR2F1, GNRHR, LHCGR
18thromboxane a246 2510.4CPOX, PTGS1
19inositol 1,4,5 trisphosphate469.4LHCGR, GNRHR, GRPR
20forskolin46 52 1211.3LHCGR, GNRHR, GRPR
21adenylate469.2GRPR, GNRHR, LHCGR
22progesterone46 30 62 25 1213.1NR2F1, GNRHR, LHCGR
23hydrogen46 2510.0GRPR, CPOX, GNRHR, LHCGR
24steroid469.0LHCGR, GNRHR, NR2F1
25actinomycin d469.0GNRHR, PTGS1, CPOX
26arginine469.0LHCGR, GNRHR, CPOX, GRPR
27arachidonic acid46 30 25 1212.0GNRHR, PTGS1, CPOX
28pge2468.8LHCGR, PTGS1, CPOX, GRPR
29cycloheximide468.8GNRHR, PTGS1, CPOX
30dexamethasone46 52 30 1211.8GRPR, CPOX, PTGS1
31oligonucleotide468.7NR2F1, AKT2, GNRHR
32glutamate468.7LHCGR, GNRHR, PTGS1, CPOX
33phosphatidylinositol468.6LHCGR, GNRHR, CPOX, AKT2, GRPR
34serine468.3LHCGR, GNRHR, PTGS1, AKT2
35alanine468.2LHCGR, GNRHR, PTGS1, CPOX, GRPR
36estrogen467.7BARD1, NR2F1, AKT2, PTGS1, GNRHR, LHCGR

GO Terms for genes affiliated with Ovarian Epithelial Cancer

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17Gene Ontology
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Biological processes related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:0421279.1GRPR, PTGS1
2G-protein coupled receptor signaling pathwayGO:0071868.7GRPR, GNRHR, LHCGR

Products for genes affiliated with Ovarian Epithelial Cancer

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Sources for Ovarian Epithelial Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet