MCID: OVR094
MIFTS: 34

Ovarian Epithelial Cancer malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Ovarian Epithelial Cancer

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Ovarian Epithelial Cancer, Aliases & Descriptions:

Name: Ovarian Epithelial Cancer 41
Epithelial Ovarian Cancer 41 60
Ovarian Epithelial Carcinoma 41
 
Ovarian Cancer, Epithelial 41
Eoc 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Ovarian Epithelial Cancer

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MalaCards based summary: Ovarian Epithelial Cancer, also known as epithelial ovarian cancer, is related to lung cancer and breast cancer. An important gene associated with Ovarian Epithelial Cancer is PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and among its related pathways are Small cell lung cancer and Development A2A receptor signaling. The compounds meloxicam and naproxen have been mentioned in the context of this disorder. Affiliated tissues include ovary, t cells and endothelial, and related mouse phenotypes are cellular and behavior/neurological.

Related Diseases for Ovarian Epithelial Cancer

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Graphical network of the top 20 diseases related to Ovarian Epithelial Cancer:



Diseases related to ovarian epithelial cancer

Symptoms for Ovarian Epithelial Cancer

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Drugs & Therapeutics for Ovarian Epithelial Cancer

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Drug clinical trials:

Search ClinicalTrials for Ovarian Epithelial Cancer

Search NIH Clinical Center for Ovarian Epithelial Cancer

Genetic Tests for Ovarian Epithelial Cancer

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Anatomical Context for Ovarian Epithelial Cancer

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MalaCards organs/tissues related to Ovarian Epithelial Cancer:

31
Ovary, T cells, Endothelial, Appendix

Animal Models for Ovarian Epithelial Cancer or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Epithelial Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.3NR2F1, AKT2, PTGS1, LHCGR, PIK3CA
2MP:00053868.2PIK3CA, LHCGR, PTGS1, NR2F1, GRPR
3MP:00107718.2PIK3CA, GNRHR, PTGS1, AKT2
4MP:00053798.1AKT2, PTGS1, GNRHR, LHCGR, PIK3CA
5MP:00028738.1GRPR, NR2F1, AKT2, GNRHR
6MP:00053898.0PIK3CA, LHCGR, GNRHR, PTGS1, AKT2
7MP:00053787.6PIK3CA, LHCGR, GNRHR, PTGS1, AKT2
8MP:00053767.4PIK3CA, LHCGR, GNRHR, PTGS1, AKT2, GRPR

Publications for Ovarian Epithelial Cancer

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Articles related to Ovarian Epithelial Cancer:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Ovarian sarcoma carries a poorer prognosis than ovarian epithelial cancer throughout all FIGO stages: a single-center case-control matched study. (25503164)
2014
2
Inhibitory role of prohibitin in human ovarian epithelial cancer. (24966933)
2014
3
The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells. (23254909)
2013
4
Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy. (24133590)
2013
5
Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance. (23652306)
2013
6
Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers. (22985132)
2012
7
Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels. (23189165)
2012
8
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. (22895947)
2012
9
Over-expression of semaphorin4D, hypoxia-inducible factor-1I+ and vascular endothelial growth factor is related to poor prognosis in ovarian epithelial cancer. (23202951)
2012
10
Novel approaches to quantify estradiol-induced loss of ERI^1 protein in older mouse ovarian surface epithelium: new tools to assess the role of ER protein subtypes in predisposing to ovarian epithelial cancer? (21773845)
2011
11
Ovarian epithelial cancer stem cells. (21666993)
2011
12
High-throughput DNA hypermethylation profiling in different ovarian epithelial cancer subtypes using universal bead array. (20811671)
2010
13
Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer. (19945796)
2010
14
Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer. (19181441)
2009
15
Analysis of serum biomarkers of ovarian epithelial cancers based on 2-DE DIGE and MALDI TOF/TOF]. (19173805)
2008
16
Multitargeting ovarian epithelial cancer: adding the old to the new. (18349413)
2008
17
Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. (18676764)
2008
18
Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. (17712227)
2007
19
Two-tier grading system for ovarian epithelial cancer: has its time arrived? (17667555)
2007
20
Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer. (16936295)
2006
21
Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication. (16961294)
2006
22
Debulking surgery for ovarian epithelial cancer performed by a gynaecological oncologist improved survival compared with less specialised surgeons. (16707225)
2006
23
Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides. (15944801)
2005
24
Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group). (15226774)
2004
25
Oncogenic pathways implicated in ovarian epithelial cancer. (12959183)
2003
26
Expression of aFGF in ovarian epithelial cancer and its signal transduction pathway]. (12899800)
2003
27
Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells. (12626776)
2003
28
Papanicolaou smears are of little value in the post-treatment surveillance of patients with ovarian epithelial cancer. (17050956)
2001
29
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. (11280739)
2001
30
The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. (10828496)
2000
31
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. (9679957)
1998
32
p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer. (9307189)
1997
33
Fertility drugs and ovarian epithelial cancer: is there a link? (8986583)
1996
34
Comparison of four methods to generate immunoreactive fragments of a murine monoclonal antibody OC859 against human ovarian epithelial cancer antigen. (7647323)
1995
35
Reduction of tumor necrosis factor-alpha bioactivity by a human ovarian epithelial cancer cell line in vitro. (7503187)
1995
36
Is there a role for CT scanning to monitor therapy of optimally debulked patients with advanced ovarian epithelial cancer? (11578380)
1994
37
A new expert system for histopathological diagnosis of human ovarian epithelial cancer. (8218981)
1993
38
Symptoms and diagnostic difficulties in ovarian epithelial cancer. (7901083)
1993
39
Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. (1592292)
1992
40
Human ovarian epithelial cancer cells cultures in vitro express both interleukin 1 alpha and beta genes. (1559228)
1992
41
High-dose, short-duration cisplatin/doxorubicin combination chemotherapy for advanced ovarian epithelial cancer. (1655227)
1991
42
Development of two new monoclonal antibodies reactive to a surface antigen present on human ovarian epithelial cancer cells. (1855217)
1991
43
A phase II trial of intraperitoneal cisplatin and etoposide for primary treatment of ovarian epithelial cancer. (2295904)
1990
44
Carbon dioxide laser vaporization of diaphragmatic metastases for cytoreduction of ovarian epithelial cancer. (2216210)
1990
45
Survival after second-look laparotomy in advanced ovarian epithelial cancer. Study of 86 patients. (2702999)
1989
46
Navelbine in advanced ovarian epithelial cancer: a study of the French oncology centers. (2652318)
1989
47
Involvement of the appendix in ovarian epithelial cancer--an update. (2595505)
1989
48
Esorubicin in advanced ovarian epithelial cancer. A phase II study of the EORTC Gynecological Cancer Cooperative Group. (3181261)
1988
49
Ovarian epithelial cancer and chemical carcinogenesis. (7308865)
1981
50
Lymphangiography in patients with ovarian epithelial cancer: an evaluation of 289 consecutive cases. (561650)
1977

Variations for Ovarian Epithelial Cancer

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Clinvar genetic disease variations for Ovarian Epithelial Cancer:

6
id Gene Variation Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091

Expression for genes affiliated with Ovarian Epithelial Cancer

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Search GEO for disease gene expression data for Ovarian Epithelial Cancer.

Pathways for genes affiliated with Ovarian Epithelial Cancer

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Pathways related to Ovarian Epithelial Cancer according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AKT2, PIK3CA
2
Show member pathways
Development A2B receptor action via G protein alpha s58
9.6AKT2, PIK3CA
3
Show member pathways
9.6PIK3CA, AKT2
4
Show member pathways
Development Flt3 signaling58
9.6PIK3CA, AKT2
5
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.6AKT2, PIK3CA
69.6PIK3CA, AKT2
7
Show member pathways
IFN-gamma pathway36
9.6PIK3CA, AKT2
89.6AKT2, PIK3CA
9
Show member pathways
9.6PIK3CA, AKT2
10
Show member pathways
Development A1 receptor signaling58
G protein signaling G Protein alpha q signaling cascades58
9.6AKT2, PIK3CA
119.6AKT2, PIK3CA
12
Show member pathways
9.6AKT2, PIK3CA
13
Show member pathways
9.6AKT2, PIK3CA
14
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis58
9.6PIK3CA, AKT2
15
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.6PIK3CA, AKT2
169.6AKT2, PIK3CA
179.6AKT2, PIK3CA
189.6PIK3CA, AKT2
19
Show member pathways
Insulin Pathway36
9.6AKT2, PIK3CA
209.6AKT2, PIK3CA
219.6AKT2, PIK3CA
229.6PIK3CA, AKT2
239.6PIK3CA, AKT2
24
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.6AKT2, PIK3CA
25
Show member pathways
9.6AKT2, PIK3CA
269.3GNRHR, LHCGR
27
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.2AKT2, LHCGR, PIK3CA
28
Show member pathways
9.1AKT2, PTGS1, PIK3CA
299.0GNRHR, GRPR
30
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.8PIK3CA, GNRHR, AKT2
31
Show member pathways
8.8PTGS1, GNRHR, LHCGR
32
Show member pathways
8.7GRPR, GNRHR, PIK3CA
33
Show member pathways
7.8PIK3CA, LHCGR, GNRHR, AKT2, GRPR

Compounds for genes affiliated with Ovarian Epithelial Cancer

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Compounds related to Ovarian Epithelial Cancer according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1meloxicam43 1211.0CPOX, PTGS1
2naproxen43 24 1211.9PTGS1, CPOX
3rofecoxib43 49 28 1212.9PTGS1, CPOX
4(+-)-pgf2-alpha439.9CPOX, PTGS1
5pgd2439.9CPOX, PTGS1
6txb2439.9CPOX, PTGS1
7prostaglandin f2alpha439.8PTGS1, LHCGR
8diclofenac43 28 49 1212.8CPOX, PTGS1
9thromboxane43 2410.8CPOX, PTGS1
10ibuprofen43 28 49 24 1213.8CPOX, PTGS1
11salicylic acid43 2810.8CPOX, PTGS1
12celecoxib43 59 28 49 24 1214.7CPOX, PTGS1
13goserelin43 28 1211.7GNRHR, LHCGR
14cetrorelix43 28 1211.7LHCGR, GNRHR
15buserelin43 28 1211.7GNRHR, LHCGR
16leuprolide acetate439.7GNRHR, LHCGR
17gefitinib43 49 1211.6GRPR, PIK3CA
18thromboxane a243 2410.6CPOX, PTGS1
19leucine439.6PIK3CA, LHCGR, CPOX
20lactate439.5PIK3CA, PTGS1, CPOX
21ag 1478439.5PIK3CA, GNRHR
22ly294002439.4AKT2, PTGS1, PIK3CA
23h2o2439.2CPOX, PTGS1, PIK3CA
24estradiol43 24 1211.2LHCGR, GNRHR, NR2F1
25tamoxifen43 49 28 1212.1AKT2, GNRHR, PIK3CA
26inositol 1,4,5 trisphosphate439.1LHCGR, GNRHR, GRPR
27cholesterol43 28 24 1212.0CPOX, LHCGR, PIK3CA
28forskolin43 49 1211.0GRPR, GNRHR, LHCGR
29pge2439.0GRPR, CPOX, PTGS1, LHCGR
30dexamethasone43 49 28 1212.0PIK3CA, PTGS1, CPOX, GRPR
31cycloheximide438.9CPOX, PTGS1, GNRHR
32progesterone43 28 59 24 1212.9NR2F1, GNRHR, LHCGR, PIK3CA
33steroid438.9NR2F1, GNRHR, LHCGR, PIK3CA
34testosterone43 59 24 1211.8PIK3CA, LHCGR, GNRHR
35actinomycin d438.8PIK3CA, GNRHR, PTGS1, CPOX
36arachidonic acid43 28 24 1211.8CPOX, PTGS1, GNRHR, PIK3CA
37adenylate438.7PIK3CA, LHCGR, GNRHR, GRPR
38hydrogen43 249.7LHCGR, GNRHR, CPOX, GRPR
39glutamate438.4PIK3CA, LHCGR, GNRHR, PTGS1, CPOX
40arginine438.3PIK3CA, LHCGR, GNRHR, CPOX, GRPR
41serine438.3AKT2, PTGS1, GNRHR, LHCGR, PIK3CA
42calcium43 49 24 1211.3PIK3CA, LHCGR, GNRHR, CPOX, GRPR
43tyrosine438.2GRPR, AKT2, GNRHR, PIK3CA
44alanine438.2GRPR, CPOX, PTGS1, GNRHR, LHCGR
45estrogen437.9PIK3CA, LHCGR, GNRHR, PTGS1, AKT2, NR2F1
46phosphatidylinositol437.8GRPR, AKT2, CPOX, GNRHR, LHCGR, PIK3CA

GO Terms for genes affiliated with Ovarian Epithelial Cancer

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Cellular components related to Ovarian Epithelial Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.8GRPR, AKT2, GNRHR, LHCGR, PIK3CA

Biological processes related to Ovarian Epithelial Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00071868.7GRPR, GNRHR, LHCGR

Molecular functions related to Ovarian Epithelial Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:00163019.6AKT2, PIK3CA

Products for genes affiliated with Ovarian Epithelial Cancer

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Sources for Ovarian Epithelial Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet