EOC
MCID: OVR094
MIFTS: 45

Ovarian Epithelial Cancer (EOC) malady

Rare diseases, Cancer diseases categories
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Summaries for Ovarian Epithelial Cancer

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MalaCards based summary: Ovarian Epithelial Cancer, also known as ovarian epithelial carcinoma, is related to ovarian cancer, somatic and lung cancer. An important gene associated with Ovarian Epithelial Cancer is PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and among its related pathways are TFs Regulate miRNAs related to cardiac hypertrophy and Hormone ligand-binding receptors. The compounds sc 79 and fpa 124 have been mentioned in the context of this disorder. Affiliated tissues include ovary, t cells and endothelial, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Ovarian Epithelial Cancer

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Ovarian Epithelial Cancer, Aliases & Descriptions:

Name: Ovarian Epithelial Cancer 42
Ovarian Epithelial Carcinoma 42 62
Epithelial Ovarian Cancer 42 62
 
Malignant Neoplasm of Ovary 62
Ovarian Cancer, Epithelial 42
Eoc 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Ovarian Epithelial Cancer

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Diseases related to Ovarian Epithelial Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer, somatic30.6AKT1, PIK3CA
2lung cancer30.3AKT1, PIK3CA
3ovarian cancer30.3PIK3CA, GNRHR, PTGS1, AKT2, GRPR
4endometrial carcinoma30.1AKT1, PIK3CA, GNRHR
5adenocarcinoma29.3AKT2, GNRHR, PIK3CA, PTGS1, GRPR, AKT1
6breast cancer29.2MUC4, CPOX, GNRHR, AKT1, PIK3CA, AKT2
7peritonitis10.7
8thrombocytosis10.5
9clear cell adenocarcinoma10.4
10ovarian cyst10.4
11peritoneal carcinoma10.4
12primary peritoneal carcinoma10.4
13obesity10.3
14wilms tumor10.3
15somatostatin analog10.3
16precocious puberty10.3LHCGR, GNRHR
17cushing's syndrome10.2LHCGR, NR2F1
18colorectal cancer, somatic10.1PIK3CA, AKT1
19malignant ovarian cyst10.1
20hemochromatosis10.1
21down syndrome10.1
22hyperandrogenism10.1
23xeroderma pigmentosum10.1
24lactose intolerance10.1
25constipation10.1
26endometriosis10.1
27fallopian tube cancer10.1
28ovary epithelial cancer10.1
29prostatitis10.1
30pseudohermaphroditism10.1
31hypoxia10.1
32thromboembolism10.1
33breast cancer susceptibility10.1
34venous thromboembolism10.1
35blindness10.1
36endotheliitis10.1
37cisplatin toxicity10.1
38factor v leiden thrombophilia10.0PIK3CA, PTGS1, CPOX
39tuberous sclerosis10.0AKT1, PIK3CA
40squamous cell carcinoma of the head and neck10.0GRPR, PIK3CA, PTGS1
41thymoma10.0AKT1, AKT2
42colorectal cancer9.9PTGS1, GRPR, PIK3CA
43insulin resistance9.9PIK3CA, AKT2, AKT1
44pancreatic cancer9.9AKT1, MUC4, AKT2
45prostate cancer9.8GRPR, AKT1, PTGS1, GNRHR
46lung adenocarcinoma9.8PIK3CA, MUC4, AKT2
47colonic benign neoplasm9.8PIK3CA, PTGS1, AKT1, GRPR
48stomach cancer9.7MUC4, PIK3CA, AKT1
49adenoma9.6GNRHR, NR2F1, LHCGR, PTGS1, MUC4
50non-small cell lung carcinoma9.6MUC4, PIK3CA, AKT1, GRPR

Graphical network of the top 20 diseases related to Ovarian Epithelial Cancer:



Diseases related to ovarian epithelial cancer

Symptoms for Ovarian Epithelial Cancer

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Drugs & Therapeutics for Ovarian Epithelial Cancer

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Drug clinical trials:

Search ClinicalTrials for Ovarian Epithelial Cancer

Search NIH Clinical Center for Ovarian Epithelial Cancer

Genetic Tests for Ovarian Epithelial Cancer

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Anatomical Context for Ovarian Epithelial Cancer

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MalaCards organs/tissues related to Ovarian Epithelial Cancer:

32
Ovary, T cells, Endothelial, Appendix

Animal Models for Ovarian Epithelial Cancer or affiliated genes

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Publications for Ovarian Epithelial Cancer

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Articles related to Ovarian Epithelial Cancer:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Inhibitory role of prohibitin in human ovarian epithelial cancer. (24966933)
2014
2
The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells. (23254909)
2013
3
Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy. (24133590)
2013
4
Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance. (23652306)
2013
5
Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers. (22985132)
2012
6
Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels. (23189165)
2012
7
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. (22895947)
2012
8
Over-expression of semaphorin4D, hypoxia-inducible factor-1I+ and vascular endothelial growth factor is related to poor prognosis in ovarian epithelial cancer. (23202951)
2012
9
Novel approaches to quantify estradiol-induced loss of ERI^1 protein in older mouse ovarian surface epithelium: new tools to assess the role of ER protein subtypes in predisposing to ovarian epithelial cancer? (21773845)
2011
10
Ovarian epithelial cancer stem cells. (21666993)
2011
11
High-throughput DNA hypermethylation profiling in different ovarian epithelial cancer subtypes using universal bead array. (20811671)
2010
12
Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer. (19945796)
2010
13
Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer. (19181441)
2009
14
Multitargeting ovarian epithelial cancer: adding the old to the new. (18349413)
2008
15
Oxidation of ovarian epithelial cancer cells by hypochlorous acid enhances immunogenicity and stimulates T cells that recognize autologous primary tumor. (18676764)
2008
16
Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. (17712227)
2007
17
Two-tier grading system for ovarian epithelial cancer: has its time arrived? (17667555)
2007
18
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. (17943850)
2007
19
Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer. (16936295)
2006
20
Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication. (16961294)
2006
21
Debulking surgery for ovarian epithelial cancer performed by a gynaecological oncologist improved survival compared with less specialised surgeons. (16707225)
2006
22
Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides. (15944801)
2005
23
Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group). (15226774)
2004
24
Borderline ovarian epithelial cancer. (21213507)
2004
25
Oncogenic pathways implicated in ovarian epithelial cancer. (12959183)
2003
26
Expression of aFGF in ovarian epithelial cancer and its signal transduction pathway]. (12899800)
2003
27
Inhibitory effects of progesterone on plasma membrane fluidity and tumorigenic potential of ovarian epithelial cancer cells. (12626776)
2003
28
Papanicolaou smears are of little value in the post-treatment surveillance of patients with ovarian epithelial cancer. (17050956)
2001
29
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. (11280739)
2001
30
The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. (10828496)
2000
31
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. (9679957)
1998
32
p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer. (9307189)
1997
33
Fertility drugs and ovarian epithelial cancer: is there a link? (8986583)
1996
34
Comparison of four methods to generate immunoreactive fragments of a murine monoclonal antibody OC859 against human ovarian epithelial cancer antigen. (7647323)
1995
35
Reduction of tumor necrosis factor-alpha bioactivity by a human ovarian epithelial cancer cell line in vitro. (7503187)
1995
36
Is there a role for CT scanning to monitor therapy of optimally debulked patients with advanced ovarian epithelial cancer? (11578380)
1994
37
A new expert system for histopathological diagnosis of human ovarian epithelial cancer. (8218981)
1993
38
Symptoms and diagnostic difficulties in ovarian epithelial cancer. (7901083)
1993
39
Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. (1592292)
1992
40
Human ovarian epithelial cancer cells cultures in vitro express both interleukin 1 alpha and beta genes. (1559228)
1992
41
High-dose, short-duration cisplatin/doxorubicin combination chemotherapy for advanced ovarian epithelial cancer. (1655227)
1991
42
Development of two new monoclonal antibodies reactive to a surface antigen present on human ovarian epithelial cancer cells. (1855217)
1991
43
A phase II trial of intraperitoneal cisplatin and etoposide for primary treatment of ovarian epithelial cancer. (2295904)
1990
44
Carbon dioxide laser vaporization of diaphragmatic metastases for cytoreduction of ovarian epithelial cancer. (2216210)
1990
45
Survival after second-look laparotomy in advanced ovarian epithelial cancer. Study of 86 patients. (2702999)
1989
46
Navelbine in advanced ovarian epithelial cancer: a study of the French oncology centers. (2652318)
1989
47
Involvement of the appendix in ovarian epithelial cancer--an update. (2595505)
1989
48
Esorubicin in advanced ovarian epithelial cancer. A phase II study of the EORTC Gynecological Cancer Cooperative Group. (3181261)
1988
49
Ovarian epithelial cancer and chemical carcinogenesis. (7308865)
1981
50
Lymphangiography in patients with ovarian epithelial cancer: an evaluation of 289 consecutive cases. (561650)
1977

Variations for Ovarian Epithelial Cancer

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Clinvar genetic disease variations for Ovarian Epithelial Cancer:

6
id Gene Name Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
3AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551

Expression for genes affiliated with Ovarian Epithelial Cancer

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Expression patterns in normal tissues for genes affiliated with Ovarian Epithelial Cancer

Search GEO for disease gene expression data for Ovarian Epithelial Cancer.

Pathways for genes affiliated with Ovarian Epithelial Cancer

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Pathways related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8AKT1, AKT2
29.6LHCGR, GNRHR
39.5AKT2, PIK3CA, AKT1
49.5AKT2, PIK3CA, AKT1
5
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.5AKT2, AKT1, PIK3CA
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.5AKT2, AKT1, PIK3CA
7
Show member pathways
9.5AKT2, PIK3CA, AKT1
8
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.5AKT1, AKT2, PIK3CA
9
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.5AKT1, AKT2, PIK3CA
10
Show member pathways
9.5AKT2, PIK3CA, AKT1
119.5AKT2, AKT1, PIK3CA
12
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.5AKT2, PIK3CA, AKT1
13
Show member pathways
Signal transduction PTEN pathway60
9.5AKT2, PIK3CA, AKT1
14
Show member pathways
9.5AKT1, AKT2, PIK3CA
159.5AKT1, AKT2, PIK3CA
169.5AKT1, AKT2, PIK3CA
17
Show member pathways
9.5AKT1, AKT2, PIK3CA
189.5AKT2, PIK3CA, AKT1
199.5AKT1, AKT2, PIK3CA
20
Show member pathways
Insulin Pathway37
9.5AKT1, AKT2, PIK3CA
219.5AKT1, AKT2, PIK3CA
229.5AKT2, AKT1, PIK3CA
23
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.5AKT1, PIK3CA, AKT2
249.5AKT1, PIK3CA, AKT2
25
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.5PIK3CA, AKT1, AKT2
269.5PIK3CA, AKT1, AKT2
279.5PIK3CA, AKT2, AKT1
28
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.5PIK3CA, AKT2, AKT1
29
Show member pathways
9.5AKT1, PIK3CA, AKT2
30
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5PIK3CA, AKT2, AKT1
31
Show member pathways
9.5PIK3CA, AKT2, AKT1
32
Show member pathways
Development A2B receptor action via G protein alpha s60
9.5PIK3CA, AKT2, AKT1
33
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5PIK3CA, AKT2, AKT1
349.5PIK3CA, AKT1, AKT2
359.5AKT1, PIK3CA, AKT2
36
Show member pathways
IFN-gamma pathway37
9.5PIK3CA, AKT2, AKT1
37
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.5PIK3CA, AKT1, AKT2
389.5PIK3CA, AKT2, AKT1
39
Show member pathways
Development Flt3 signaling60
9.5PIK3CA, AKT2, AKT1
40
Show member pathways
9.5PIK3CA, AKT2, AKT1
41
Show member pathways
9.5PIK3CA, AKT2, AKT1
42
Show member pathways
9.5PIK3CA, AKT1, AKT2
439.5AKT1, PIK3CA, AKT2
449.5PIK3CA, AKT2, AKT1
45
Show member pathways
Peptide GPCRs37
9.2LHCGR, GNRHR, GRPR
46
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.2LHCGR, AKT1, PIK3CA, AKT2
47
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.1PIK3CA, BARD1, AKT1
48
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.0AKT1, AKT2, PIK3CA, GNRHR
49
Show member pathways
8.9AKT2, PTGS1, PIK3CA, AKT1
50
Show member pathways
8.2AKT2, GNRHR, PIK3CA, GRPR, AKT1, LHCGR

Compounds for genes affiliated with Ovarian Epithelial Cancer

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Compounds related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1sc 796110.2AKT2, AKT1
2fpa 1246110.2AKT2, AKT1
310-debc hydrochloride6110.2AKT1, AKT2
4api-26110.2AKT1, AKT2
5api-16110.2AKT2, AKT1
6everolimus44 50 1112.2AKT1, PIK3CA
7ptdins(3)p4410.1PIK3CA, AKT1
8goserelin44 28 1112.0GNRHR, LHCGR
9cetrorelix44 28 1112.0LHCGR, GNRHR
10buserelin44 28 1112.0LHCGR, GNRHR
11leuprolide acetate4410.0GNRHR, LHCGR
12meloxicam44 1110.9PTGS1, CPOX
13gefitinib44 50 1111.8GRPR, PIK3CA, AKT1
14rofecoxib44 50 28 1112.8CPOX, PTGS1
15ag 1478449.8AKT1, PIK3CA, GNRHR
16naproxen44 24 1111.8CPOX, PTGS1
17(+-)-pgf2-alpha449.6PTGS1, CPOX
18celecoxib44 61 28 50 24 1114.6PTGS1, CPOX, AKT1
19gnrh449.5AKT1, GNRHR, LHCGR
20inositol 1,4,5 trisphosphate449.5GNRHR, GRPR, LHCGR
21prostacyclin449.5PTGS1, CPOX, AKT1
22agar449.4PTGS1, PIK3CA, AKT1
23matrigel449.4AKT1, MUC4, PIK3CA
24tamoxifen44 50 28 1112.4AKT2, PIK3CA, GNRHR, AKT1
25testosterone44 61 24 1112.3AKT1, GNRHR, LHCGR, PIK3CA
26nmda44 2810.3AKT1, PTGS1, PIK3CA
27ly294002449.3PIK3CA, AKT2, AKT1, PTGS1
28h2o2449.2CPOX, AKT1, PTGS1, PIK3CA
29cholesterol44 28 24 1112.2CPOX, LHCGR, PIK3CA, MUC4
30hydrogen44 2410.2LHCGR, GNRHR, CPOX, GRPR
31etoposide44 50 61 1112.2PIK3CA, PTGS1, AKT1
32arachidonic acid44 28 24 1112.1PIK3CA, PTGS1, GNRHR, CPOX
33cycloheximide449.0GNRHR, AKT1, CPOX, PTGS1
34adenylate449.0PIK3CA, LHCGR, GRPR, AKT1, GNRHR
35progesterone44 28 61 24 1112.9LHCGR, PIK3CA, NR2F1, GNRHR, MUC4
36vegf448.9GRPR, AKT1, PIK3CA, PTGS1
37pge2448.9AKT1, CPOX, PTGS1, LHCGR, GRPR
38steroid448.9PIK3CA, GNRHR, NR2F1, MUC4, LHCGR
39threonine448.9PIK3CA, LHCGR, AKT2, AKT1
40actinomycin d448.8AKT1, PIK3CA, GNRHR, PTGS1, CPOX
41oligonucleotide448.8AKT2, GNRHR, NR2F1, MUC4
42arginine448.7CPOX, AKT1, LHCGR, PIK3CA, GRPR, GNRHR
43glutamate448.5PTGS1, PIK3CA, LHCGR, AKT1, CPOX, GNRHR
44serine448.4LHCGR, AKT2, AKT1, PTGS1, GNRHR, PIK3CA
45dexamethasone44 50 28 1111.4MUC4, GRPR, PIK3CA, CPOX, PTGS1, AKT1
46tyrosine448.4GRPR, PIK3CA, GNRHR, AKT2, AKT1, MUC4
47calcium44 50 24 1111.4LHCGR, GNRHR, CPOX, MUC4, GRPR, PIK3CA
48alanine448.3LHCGR, GRPR, GNRHR, PTGS1, AKT1, CPOX
49phosphatidylinositol447.8AKT1, AKT2, MUC4, CPOX, GNRHR, LHCGR
50estrogen446.8MUC4, BARD1, NR2F1, AKT1, AKT2, PTGS1

GO Terms for genes affiliated with Ovarian Epithelial Cancer

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Biological processes related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.0AKT1, AKT2
2positive regulation of glucose metabolic processGO:01090710.0AKT1, AKT2
3peripheral nervous system myelin maintenanceGO:03228710.0AKT2, AKT1
4mammary gland epithelial cell differentiationGO:0606449.9AKT1, AKT2
5positive regulation of glycogen biosynthetic processGO:0457259.9AKT2, AKT1
6glycogen biosynthetic processGO:0059789.8AKT1, AKT2
7protein kinase B signalingGO:0434919.8AKT1, PIK3CA
8positive regulation of glucose importGO:0463269.8AKT2, AKT1
9regulation of cell migrationGO:0303349.8AKT1, AKT2
10glucose metabolic processGO:0060069.7AKT1, AKT2, PIK3CA
11insulin receptor signaling pathwayGO:0082869.6AKT1, AKT2, PIK3CA
12positive regulation of peptidyl-serine phosphorylationGO:0331389.6AKT1, PIK3CA
13G-protein coupled receptor signaling pathwayGO:0071869.1GRPR, AKT1, GNRHR, LHCGR

Molecular functions related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine kinase activityGO:0046749.5AKT1, AKT2, PIK3CA
2kinase activityGO:0163019.2AKT1, AKT2, PIK3CA

Products for genes affiliated with Ovarian Epithelial Cancer

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  • Antibodies
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Sources for Ovarian Epithelial Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet