EOC
MCID: OVR094
MIFTS: 33

Ovarian Epithelial Cancer (EOC) malady

Cancer diseases category

Summaries for Ovarian Epithelial Cancer

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32MalaCards
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MalaCards: Ovarian Epithelial Cancer, also known as epithelial ovarian cancer, is related to ovarian cancer and adenocarcinoma. An important gene associated with Ovarian Epithelial Cancer is KLF8 (Kruppel-like factor 8), and among its related pathways are Glycoprotein hormones and Development Endothelin-1/EDNRA signaling. The compounds [leu8]-phyllolitorin and d-nal,cys,tyr,d-trp,orn,val,cys,nal-nh2 have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are renal/urinary system and behavior/neurological.

Aliases & Classifications for Ovarian Epithelial Cancer

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian epithelial cancer 42
epithelial ovarian cancer 42 60
ovarian epithelial carcinoma 42
malignant neoplasm of ovary 60
ovarian cancer, epithelial 42
eoc 42


Related Diseases for Ovarian Epithelial Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Epithelial Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer31.5PTGS1, GRPR, AKT2, SNCG, GNRHR, XIAP
2adenocarcinoma30.6NMBR, XIAP, GNRHR, SNCG, AKT2, GRPR
3obesity30.3GRP, BRS3
4lung cancer30.3BRS3, XIAP, AKT2, GRPR, GRP, NMBR
5breast cancer30.3GNRHR, SNCG, AKT2, GRP, CPOX
6endometriosis30.1GNRHR, HP
7ovarian disease10.8
8peritonitis10.6
9lymph node cancer10.5
10thrombocytosis10.5
11clear cell adenocarcinoma10.4
12ovarian clear cell adenocarcinoma10.4
13ovarian cyst10.4
14ovarian wilms' cancer10.2
15fallopian tube cancer10.2
16ovarian benign neoplasm10.2
17retroperitoneal cancer10.2
18ovarian cancer, somatic10.2
19ovarian gonadoblastoma10.1
20non-gestational ovarian choriocarcinoma10.1
21ovary adenocarcinoma10.1
22gynandroblastoma10.1
23ovarian cancer, childhood10.1
24breast-ovarian cancer, familial, 210.1
25ovarian dysgenesis 310.1
26borderline ovarian epithelial tumor10.1
27malignant mixed epithelial mesenchymal tumor of the ovary10.1
28hereditary site-specific ovarian cancer syndrome10.1
29ovarian malignant tumor of sex cord-stromal origin10.1
30ovarian germ cell malignant tumor10.1
31theca steroid-producing cell malignant tumor, not further specified10.1
32ovarian malignant sertoli-leydig cell tumor10.1
33granulosa cell malignant tumor10.1
34malignant dysgerminomatous germ cell tumor10.1
35ovarian endometriosis10.1
36xeroderma pigmentosum10.1
37hyperandrogenism10.1
38hemochromatosis10.1
39sporadic breast cancer10.1
40malignant ovarian cyst10.1
41lactose intolerance10.1
42down syndrome10.1
43brain cancer10.1
44cell type cancer10.1
45constipation10.1
46endometrial carcinoma10.1
47leukocyte disease10.1
48ovary epithelial cancer10.1
49prostatitis10.1
50pseudohermaphroditism10.1

Graphical network of the top 20 diseases related to Ovarian Epithelial Cancer:



Diseases related to ovarian epithelial cancer

Clinical Features for Ovarian Epithelial Cancer

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Drugs & Therapeutics for Ovarian Epithelial Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Ovarian Epithelial Cancer

Drug clinical trials:

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Search NIH Clinical Center for Ovarian Epithelial Cancer

Search CenterWatch for Ovarian Epithelial Cancer

Genetic Tests for Ovarian Epithelial Cancer

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Anatomical Context for Ovarian Epithelial Cancer

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32MalaCards
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MalaCards organs/tissues related to Ovarian Epithelial Cancer:

32
Ovary

Animal Models for Ovarian Epithelial Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Epithelial Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0GNRHR, HP, CFI, PTGS1, PTGER1, LHCGR
2MP:00053869.6ILF3, GRPR, NR2F1, SNCG, XIAP, BRS3
3MP:00053849.5PTGER1, PTGS1, XIAP, HP, BARD1, NR2F1
4MP:00053769.5BRS3, PTGER1, PTGS1, CFI, NMBR, ILF3
5MP:00053789.4ILF3, PTGS1, XIAP, BARD1, AKT2, GNRHR

Publications for Ovarian Epithelial Cancer

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Genetic Variations for Ovarian Epithelial Cancer

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Expression for genes affiliated with Ovarian Epithelial Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Epithelial Cancer

Search GEO for disease gene expression data for Ovarian Epithelial Cancer.

Pathways for genes affiliated with Ovarian Epithelial Cancer

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Sources:
53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ovarian Epithelial Cancer

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Sources:
28IUPHAR, 44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1[leu8]-phyllolitorin2810.7GRPR, NMBR
2d-nal,cys,tyr,d-trp,orn,val,cys,nal-nh2 2810.7NMBR, GRPR
3[125i][tyr4]bombesin2810.7NMBR, GRPR
4gastrin releasing peptide (14-27) (human)2810.7GRPR, NMBR
58-aminooctanoic acid4410.7GRP, GRPR
6rhodei-litorin2810.7NMBR, GRPR
7estrogen4410.7SNCG, NR2F1, BARD1
8mk-50462810.7BRS3, GRPR, NMBR
9neuromedin b (1-30) (human)2810.7NMBR, GRPR
10bantag-12810.7BRS3, GRPR, NMBR
11d-nal-cys-tyr-d-trp-lys-val-cys-nal-nh22810.7BRS3, GRPR, NMBR
12pd 1683682810.7NMBR, GRPR
13[d-phe6,β-ala11,phe13,nle14]bombesin-(6-14)2810.7BRS3, GRPR, NMBR
14pge24410.7LHCGR, GRP, CPOX
15neuromedin b28 2411.6NMBR, GRPR
16phyllolitorin28 4411.6GRPR, GRP, NMBR
17ranatensin44 2811.6GRPR, GRP, NMBR
18dexamethasone44 49 28 1113.6GRP, GRPR, XIAP
192-pyrrolinodoxorubicin4410.6GRP, GRPR
20forskolin44 49 1112.6GRPR, GNRHR, LHCGR
21grp (human)5910.6NMBR, GRP, GRPR, BRS3
22cetrorelix44 28 1112.6LHCGR, GNRH2, GNRHR, GRP
23neuromedin b (porcine)5910.6NMBR, GRP, GRPR, BRS3
24bombesin59 2811.6NMBR, GRP, GRPR, BRS3
25grp (porcine)5910.6BRS3, GRPR, GRP, NMBR
26pd 17625259 2811.6NMBR, GRP, GRPR, BRS3
27(+-)-pgf2-alpha4410.6PTGS1, PTGER1, CPOX
28pgd24410.5PTGS1, PTGER1, CPOX
29inositol 1,4,5 trisphosphate4410.5NMBR, GRP, GRPR, GNRHR, LHCGR
30cycloheximide4410.5GNRHR
31estradiol44 11 2412.4LHCGR, XIAP, GNRHR, NR2F1, CFI
32thromboxane44 2411.4CPOX, PTGER1, PTGS1
33actinomycin d4410.4XIAP, GNRHR, GRP, HP, PTGS1, CPOX
34serine4410.4LHCGR, GNRHR, AKT2, HP, PTGS1
35arachidonic acid44 28 11 2413.4GNRHR, GRP, HP, PTGS1, PTGER1, CPOX
36adenylate4410.4LHCGR, GNRHR, GRPR, GRP, HP, PTGER1
37aspirin44 49 28 2413.4CPOX, PTGS1, HP, GRP
38phosphatidylinositol4410.3LHCGR, XIAP, GNRHR, AKT2, GRPR, GRP
39gnrh4410.3LHCGR, GNRH2, GNRHR, GRP
40prostaglandin f2alpha4410.3PTGS1, GRP, LHCGR
41alanine4410.3LHCGR, GNRHR, GRPR, GRP, HP, PTGS1
4211-deoxy-pge14410.3PTGER1, PTGS1
43agar4410.3XIAP, SNCG, GRP, PTGS1
44arginine4410.3LHCGR, BRS3, GNRHR, GRPR, GRP, CPOX
45vegf4410.2XIAP, GRPR, GRP, HP, PTGS1, PTGER1
46thromboxane a244 2411.1PTGS1, PTGER1, CPOX
47indomethacin44 59 28 1113.1CPOX, PTGER1, PTGS1, GRP
48tyrosine4410.1XIAP, GNRH2, GNRHR, SNCG, AKT2, GRPR
49-, methyl ester4410.0PTGER1, GRPR
50calcium44 49 11 2412.8LHCGR, BRS3, XIAP, GNRHR, SNCG, GRPR

GO Terms for genes affiliated with Ovarian Epithelial Cancer

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16Gene Ontology
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Biological processes related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:04212710.3PTGS1, GRPR, XIAP
2G-protein coupled receptor signaling pathwayGO:0071869.8PTGER1, NMBR, GRPR, GNRHR, LHCGR

Molecular functions related to Ovarian Epithelial Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bombesin receptor activityGO:00494610.2NMBR, GRPR, BRS3

Products for genes affiliated with Ovarian Epithelial Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Epithelial Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet