MCID: OVR097
MIFTS: 31

Ovarian Fibrothecoma

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

MalaCards integrated aliases for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 55
Ovarian Thecoma 69

Characteristics:

Orphanet epidemiological data:

55
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to adenofibroma and lymphedema, hereditary, ii, and has symptoms including hirsutism, ascites and abdominal pain. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary.

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 adenofibroma 10.1 ACTC1 CALB2
2 lymphedema, hereditary, ii 10.1
3 horseshoe kidney 10.1 ACTC1 CALB2
4 fibroblastic rheumatism 10.1 ACTC1 DES
5 angiolipoma 10.1 ACTC1 DES
6 cutaneous leiomyosarcoma 10.1 ACTC1 DES
7 spindle cell lipoma 10.1 ACTC1 DES
8 parachordoma 10.1 ACTC1 DES
9 ossifying fibromyxoid tumor 10.1 ACTC1 DES
10 epithelioid leiomyosarcoma 10.1 ACTC1 DES
11 syringocystadenoma papilliferum 10.1 ACTC1 DES
12 benign metastasizing leiomyoma 10.1 ACTC1 DES
13 congenital fibrosarcoma 10.1 ACTC1 DES
14 pleomorphic liposarcoma 10.1 ACTC1 DES
15 ischemic fasciitis 10.1 ACTC1 DES
16 cutaneous fibrous histiocytoma 10.1 ACTC1 DES
17 reticulum cell sarcoma 10.1 ACTC1 DES
18 dedifferentiated liposarcoma 10.1 ACTC1 DES
19 spindle cell sarcoma 10.1 ACTC1 DES
20 pseudosarcomatous fibromatosis 10.0 ACTC1 DES
21 glomus tumor 10.0 ACTC1 DES
22 non-langerhans-cell histiocytosis 10.0 ACTC1 DES
23 infantile myofibromatosis 10.0 ACTC1 DES
24 hemangiopericytoma, malignant 10.0 ACTC1 DES
25 benign mesothelioma 10.0 CALB2 DES
26 malignant fibroxanthoma 10.0 ACTC1 DES
27 chondromyxoid fibroma 10.0 ACTC1 DES
28 botryoid rhabdomyosarcoma 10.0 ACTC1 DES
29 fasciitis 10.0 ACTC1 DES
30 glomangioma 10.0 ACTC1 DES
31 spindle cell carcinoma 10.0 ACTC1 DES
32 familial isolated dilated cardiomyopathy 9.9 ACTC1 DES
33 rhabdoid cancer 9.9 ACTC1 DES
34 ovarian melanoma 9.9 CALB2 KIT
35 desmoplastic small round cell tumor 9.9 ACTC1 DES
36 malignant leydig cell tumor 9.9 CALB2 KIT
37 rete testis adenocarcinoma 9.9 CALB2 KIT
38 neurogenic bowel 9.9 CALB2 KIT
39 spindle cell liposarcoma 9.9 CALB2 KIT
40 hydrops, lactic acidosis, and sideroblastic anemia 9.9
41 sarcoma 9.9
42 retroperitoneal sarcoma 9.9
43 amenorrhea 9.9
44 leiomyomatosis 9.9
45 infertility 9.9
46 mulibrey nanism 9.9
47 rete testis neoplasm 9.9 CALB2 KIT
48 fibrous histiocytoma 9.9 ACTC1 DES
49 functional colonic disease 9.9 CALB2 KIT
50 necrotizing sialometaplasia 9.9 ACTC1 KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

55 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hirsutism 55 31 occasional (7.5%) Occasional (29-5%) HP:0001007
2 ascites 55 31 frequent (33%) Frequent (79-30%) HP:0001541
3 abdominal pain 55 31 hallmark (90%) Very frequent (99-80%) HP:0002027
4 pleural effusion 55 31 hallmark (90%) Very frequent (99-80%) HP:0002202
5 peritonitis 55 31 frequent (33%) Frequent (79-30%) HP:0002586
6 abdominal distention 55 31 hallmark (90%) Very frequent (99-80%) HP:0003270
7 diffuse leiomyomatosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0006756
8 gonadal calcification 55 31 occasional (7.5%) Occasional (29-5%) HP:0008703
9 ovarian fibroma 55 31 hallmark (90%) Very frequent (99-80%) HP:0010618
10 increased serum testosterone level 55 31 occasional (7.5%) Occasional (29-5%) HP:0030088
11 abnormality of the endometrium 55 31 occasional (7.5%) Occasional (29-5%) HP:0030126
12 fibrosarcoma 55 31 occasional (7.5%) Occasional (29-5%) HP:0100244
13 metrorrhagia 55 31 hallmark (90%) Very frequent (99-80%) HP:0100608
14 abnormality of the ovary 55 Very frequent (99-80%)
15 abnormality of circulating hormone level 55 Occasional (29-5%)

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

38
Ovary

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show all 21)
# Title Authors Year
1
Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma. ( 28693292 )
2017
2
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. ( 27689825 )
2016
3
Imaging Findings of Ovarian Fibrothecoma. ( 26564451 )
2015
4
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. ( 25635214 )
2014
5
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. ( 25556284 )
2014
6
Unilateral ovarian fibrothecoma with menorrhagia. ( 24763236 )
2014
7
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. ( 23431489 )
2013
8
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. ( 22096681 )
2011
9
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. ( 18813938 )
2009
10
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. ( 19329943 )
2009
11
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. ( 19675518 )
2009
12
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. ( 16965622 )
2006
13
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. ( 17415856 )
2004
14
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. ( 14617484 )
2003
15
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. ( 11426907 )
2001
16
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. ( 10685524 )
2000
17
Ovarian fibrothecoma with massive edema. ( 11019495 )
2000
18
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. ( 10836709 )
2000
19
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. ( 7656212 )
1995
20
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. ( 7999713 )
1994
21
Ovarian fibrothecoma: sonographic and histologic findings. ( 1662660 )
1991

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 ACTC1 DES
2 11.14 DES KIT
3 10.81 ACTC1 DES
4 10.35 ACTC1 KIT

GO Terms for Ovarian Fibrothecoma

Cellular components related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES KIT

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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