MCID: OVR097
MIFTS: 25

Ovarian Fibrothecoma malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

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Sources:
52Orphanet, 66UMLS, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 52
 
Ovarian Thecoma 66

Characteristics:

Orphanet epidemiological data:

52
ovarian fibrothecoma:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet52 ORPHA314478
ICD10 via Orphanet29 D27

Summaries for Ovarian Fibrothecoma

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MalaCards based summary: Ovarian Fibrothecoma, also known as ovarian thecoma, is related to meige syndrome and hypoparathyroidism-intellectual disability-dysmorphism syndrome, and has symptoms including Array, Array and Array. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. Affiliated tissues include ovary.

Related Diseases for Ovarian Fibrothecoma

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Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1meige syndrome29.9ACTC1, DES
2hypoparathyroidism-intellectual disability-dysmorphism syndrome10.2ACTC1, CALB2
3intravascular fasciitis10.1ACTC1, DES
4skin lipoma10.1ACTC1, DES
5lymphangiosarcoma10.1ACTC1, DES
6chondroblastoma10.1ACTC1, DES
7pulmonary venoocclusive disease10.1ACTC1, DES
8mollaret meningitis10.1ACTC1, DES
9malignant glandular tumor of peripheral nerve sheath10.1ACTC1, DES
10pleuropulmonary blastoma type 210.1ACTC1, DES
11skin glomangioma10.1ACTC1, DES
12short-rib thoracic dysplasia 1210.1ACTC1, DES
13t-cell childhood acute lymphocytic leukemia10.1ACTC1, DES
14parovarian cyst10.1ACTC1, DES
15staphyloenterotoxemia10.0ACTC1, DES
16orbit rhabdomyosarcoma10.0ACTC1, DES
17gallbladder leiomyosarcoma10.0ACTC1, DES
18epidural neoplasm10.0ACTC1, DES
19mild phosphoribosylpyrophosphate synthetase superactivity9.9ACTC1, DES
20sublingual gland adenoid cystic carcinoma9.9CALB2, KIT
21ovarian cyst9.9CALB2, KIT
22mulibrey nanism9.9
23sarcoma9.9
24retroperitoneal sarcoma9.9
25amenorrhea9.9
26leiomyomatosis9.9
27infertility9.9
28lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy9.9ACTC1, CALB2
29malignant sertoli-leydig cell tumor9.9CALB2, KIT
30sphenoidal sinus cancer9.9CALB2, KIT
31anus leiomyosarcoma9.9ACTC1, DES
32localized pulmonary fibrosis9.9CALB2, KIT
33megarbane jalkh syndrome9.9ACTC1, DES
34vulvar liposarcoma9.9CALB2, KIT
35longitudinal vaginal septum9.9ACTC1, DES
36lynch syndrome9.9CALB2, KIT
37sialolithiasis9.9ACTC1, KIT
38breast rhabdomyosarcoma9.8DES, KIT
39breast squamous cell carcinoma9.8CALB2, KIT
40intestinal pseudo-obstruction9.8CALB2, KIT
41dysembryoplastic neuroepithelial tumor9.8DES, KIT
42polyomavirus allograft nephropathy9.8ACTC1, KIT
43focal chorioretinitis9.8DES, KIT
44emerinopathy9.8DES, KIT
45familial mitral valve prolapse9.7ACTC1, KIT
46neutrophil immunodeficiency syndrome9.7ACTC1, DES
47ectodermal dysplasia9.7ACTC1, DES
48vulvar sebaceous carcinoma9.7DES, KIT
49ulceroglandular tularemia9.4ACTC1, DES
50pura syndrome9.4ACTC1, DES, KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to ovarian fibrothecoma

Symptoms for Ovarian Fibrothecoma

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Symptoms:

 52 (show all 15)
  • abnormality of the ovary
  • hirsutism
  • ascites
  • abdominal pain
  • pleural effusion
  • peritonitis
  • abnormality of circulating hormone level
  • abdominal distention
  • diffuse leiomyomatosis
  • gonadal calcification
  • ovarian fibroma
  • increased testosterone
  • abnormality of the endometrium
  • fibrosarcoma
  • metrorrhagia

Drugs & Therapeutics for Ovarian Fibrothecoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

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Anatomical Context for Ovarian Fibrothecoma

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MalaCards organs/tissues related to Ovarian Fibrothecoma:

34
Ovary

Animal Models for Ovarian Fibrothecoma or affiliated genes

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Publications for Ovarian Fibrothecoma

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Articles related to Ovarian Fibrothecoma:

(show all 19)
idTitleAuthorsYear
1
Imaging Findings of Ovarian Fibrothecoma. (26564451)
2015
2
Unilateral ovarian fibrothecoma with menorrhagia. (24763236)
2014
3
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. (25635214)
2014
4
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. (25556284)
2014
5
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. (23431489)
2013
6
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. (22096681)
2011
7
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. (19675518)
2009
8
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. (18813938)
2009
9
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. (19329943)
2009
10
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. (16965622)
2006
11
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. (17415856)
2004
12
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. (14617484)
2003
13
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. (11426907)
2001
14
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. (10836709)
2000
15
Ovarian fibrothecoma with massive edema. (11019495)
2000
16
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. (10685524)
2000
17
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. (7656212)
1995
18
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. (7999713)
1994
19
Ovarian fibrothecoma: sonographic and histologic findings. (1662660)
1991

Variations for Ovarian Fibrothecoma

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Expression for genes affiliated with Ovarian Fibrothecoma

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Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for genes affiliated with Ovarian Fibrothecoma

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Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3ACTC1, DES
29.1ACTC1, KIT
39.0DES, KIT

GO Terms for genes affiliated with Ovarian Fibrothecoma

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Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.3ACTC1, DES

Sources for Ovarian Fibrothecoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet