MCID: OVR097
MIFTS: 26

Ovarian Fibrothecoma malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

Aliases & Descriptions for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 56
Ovarian Thecoma 69

Characteristics:

Orphanet epidemiological data:

56
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA314478
ICD10 via Orphanet 34 D27

Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to lymphangiosarcoma and hunter macpherson syndrome, and has symptoms including hirsutism, ascites and abdominal pain. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Dilated cardiomyopathy and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary.

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 lymphangiosarcoma 10.1 ACTC1 CALB2
2 hunter macpherson syndrome 10.1 ACTC1 CALB2
3 13q12.3 microdeletion syndrome 10.1 ACTC1 DES
4 oral erosive lichen 10.1 ACTC1 DES
5 vagina leiomyosarcoma 10.1 ACTC1 DES
6 osteomyelitis 10.1 ACTC1 DES
7 myoma 10.1 ACTC1 DES
8 congenital myasthenic syndrome 10.1 ACTC1 DES
9 spleen angiosarcoma 10.1 ACTC1 DES
10 malignant dermis tumor 10.1 ACTC1 DES
11 urethral cancer 10.1 ACTC1 DES
12 biemond syndrome 10.1 ACTC1 DES
13 intestinal obstruction 10.1 ACTC1 DES
14 petrous apex meningioma 10.1 CALB2 DES
15 male urethral cancer 10.1 ACTC1 DES
16 episodic ataxia 10.1 ACTC1 DES
17 mediastinum liposarcoma 10.1 ACTC1 DES
18 coronary stenosis 10.1 ACTC1 DES
19 dyslexia 10.1 ACTC1 DES
20 house allergic alveolitis 10.1 ACTC1 DES
21 glomangioma 10.1 ACTC1 DES
22 omodysplasia 2 10.1 ACTC1 DES
23 tinea favosa 10.1 ACTC1 DES
24 t-cell childhood lymphoblastic lymphoma 10.1 ACTC1 DES
25 lung benign neoplasm 10.1 ACTC1 DES
26 orthostatic proteinuria 10.1 ACTC1 DES
27 spindle cell rhabdomyosarcoma 10.0 ACTC1 DES
28 scirrhous adenocarcinoma 10.0 ACTC1 DES
29 meige syndrome 10.0
30 hyperpituitarism 10.0 ACTC1 DES
31 ostertagiasis 10.0 ACTC1 DES
32 caroli disease 10.0 ACTC1 DES
33 juvenile xanthogranuloma 10.0 ACTC1 DES
34 parotid gland adenoid cystic carcinoma 10.0 CALB2 KIT
35 diabetes persistent mullerian ducts 10.0 ACTC1 DES
36 paranasal sinus cancer 10.0 CALB2 KIT
37 sphenoid sinus squamous cell carcinoma 10.0 CALB2 KIT
38 hormone producing pituitary cancer 10.0 CALB2 KIT
39 neutrophil immunodeficiency syndrome 10.0 ACTC1 DES
40 bejel 10.0 CALB2 KIT
41 preretinal fibrosis 10.0 ACTC1 DES
42 cranial nerve disease 10.0 CALB2 KIT
43 plasmodium ovale malaria 10.0 ACTC1 KIT
44 testis sarcoma 10.0 DES KIT
45 marfanoid hypermobility syndrome 10.0 DES KIT
46 popliteal pterygium syndrome, bartsocas-papas type 10.0 ACTC1 KIT
47 liver angiosarcoma 10.0 DES KIT
48 pneumonia 10.0 CALB2 KIT
49 glycerol kinase deficiency, adult form 10.0 ACTC1 KIT
50 rectal neoplasm 10.0 DES KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

56 32 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hirsutism 56 32 Occasional (29-5%) HP:0001007
2 ascites 56 32 Frequent (79-30%) HP:0001541
3 abdominal pain 56 32 Very frequent (99-80%) HP:0002027
4 pleural effusion 56 32 Very frequent (99-80%) HP:0002202
5 peritonitis 56 32 Frequent (79-30%) HP:0002586
6 abdominal distention 56 32 Very frequent (99-80%) HP:0003270
7 diffuse leiomyomatosis 56 32 Occasional (29-5%) HP:0006756
8 gonadal calcification 56 32 Occasional (29-5%) HP:0008703
9 ovarian fibroma 56 32 Very frequent (99-80%) HP:0010618
10 abnormality of the endometrium 56 32 Occasional (29-5%) HP:0030126
11 fibrosarcoma 56 32 Occasional (29-5%) HP:0100244
12 metrorrhagia 56 32 Very frequent (99-80%) HP:0100608
13 abnormality of the ovary 56 Very frequent (99-80%)
14 abnormality of circulating hormone level 56 Occasional (29-5%)
15 increased testosterone 56 Occasional (29-5%)
16 increased serum testosterone level 32 HP:0030088

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

39
Ovary

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show all 20)
id Title Authors Year
1
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. ( 27689825 )
2016
2
Imaging Findings of Ovarian Fibrothecoma. ( 26564451 )
2015
3
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. ( 25556284 )
2014
4
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. ( 25635214 )
2014
5
Unilateral ovarian fibrothecoma with menorrhagia. ( 24763236 )
2014
6
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. ( 23431489 )
2013
7
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. ( 22096681 )
2011
8
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. ( 18813938 )
2009
9
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. ( 19329943 )
2009
10
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. ( 19675518 )
2009
11
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. ( 16965622 )
2006
12
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. ( 17415856 )
2004
13
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. ( 14617484 )
2003
14
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. ( 11426907 )
2001
15
Ovarian fibrothecoma with massive edema. ( 11019495 )
2000
16
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. ( 10685524 )
2000
17
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. ( 10836709 )
2000
18
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. ( 7656212 )
1995
19
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. ( 7999713 )
1994
20
Ovarian fibrothecoma: sonographic and histologic findings. ( 1662660 )
1991

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 ACTC1 DES
2 11.14 DES KIT
3 10.81 ACTC1 DES
4 10.35 ACTC1 KIT

GO Terms for Ovarian Fibrothecoma

Cellular components related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES KIT

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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