MCID: OVR097
MIFTS: 28

Ovarian Fibrothecoma

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

MalaCards integrated aliases for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 56
Ovarian Thecoma 69

Characteristics:

Orphanet epidemiological data:

56
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to lymphangiosarcoma and human t-cell leukemia virus type 1, and has symptoms including hirsutism, ascites and abdominal pain. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Striated Muscle Contraction. Affiliated tissues include ovary.

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 lymphangiosarcoma 10.3 ACTC1 CALB2
2 human t-cell leukemia virus type 1 10.2 ACTC1 CALB2
3 telo2-related intellectual disability-neurodevelopmental disorder 10.2 ACTC1 DES
4 aortic aneurysm 10.2 ACTC1 DES
5 esophagus leiomyosarcoma 10.2 ACTC1 DES
6 spleen angiosarcoma 10.2 ACTC1 DES
7 myoma 10.2 ACTC1 DES
8 skin lipoma 10.2 ACTC1 DES
9 laryngeal neuroendocrine tumor 10.2 ACTC1 DES
10 uniparental disomy of chromosome 11 10.2 ACTC1 DES
11 myxoid leiomyosarcoma 10.2 ACTC1 DES
12 berk-tabatznik syndrome 10.2 ACTC1 DES
13 follicular infundibulum tumor 10.2 ACTC1 DES
14 childhood pleomorphic rhabdomyosarcoma 10.2 CALB2 DES
15 spindle cell liposarcoma 10.2 ACTC1 DES
16 neurofibroma of the esophagus 10.2 ACTC1 DES
17 juvenile xanthogranuloma 10.2 ACTC1 DES
18 short-rib thoracic dysplasia 12 10.2 ACTC1 DES
19 coronary restenosis 10.1 ACTC1 DES
20 secondary pulmonary hemosiderosis 10.1 ACTC1 DES
21 splenic manifestation of prolymphocytic leukemia 10.1 ACTC1 DES
22 nephrogenic adenoma of urinary bladder 10.1 ACTC1 DES
23 glomangioma 10.1 ACTC1 DES
24 multiple mitochondrial dysfunctions syndrome 2 10.1 ACTC1 DES
25 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.1 ACTC1 DES
26 chondroblastoma 10.1 CALB2 DES
27 ischemia 10.1 ACTC1 DES
28 angelman syndrome due to imprinting defect in 15q11-q13 10.1 ACTC1 DES
29 esophagus leiomyoma 10.1 ACTC1 DES
30 meige syndrome 10.0
31 hyperpituitarism 10.0 ACTC1 DES
32 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 10.0 ACTC1 DES
33 linitis plastica 10.0 ACTC1 DES
34 cerebrum cancer 10.0 ACTC1 DES
35 sublingual gland adenoid cystic carcinoma 10.0 CALB2 KIT
36 malignant sertoli-leydig cell tumor 10.0 CALB2 KIT
37 dextrocardia with situs inversus 10.0 ACTC1 DES
38 bejel 10.0 CALB2 KIT
39 sphenoid sinus squamous cell carcinoma 10.0 CALB2 KIT
40 cutaneous liposarcoma 9.9 CALB2 KIT
41 placental insufficiency 9.9 CALB2 KIT
42 oesophagostomiasis 9.9 ACTC1 DES
43 urethral villous adenoma 9.9 CALB2 KIT
44 malignant adenofibroma 9.9 ACTC1 DES
45 plasmodium ovale malaria 9.9 ACTC1 KIT
46 nasal cavity squamous cell carcinoma 9.9 CALB2 KIT
47 polyosteolysis/hyperostosis syndrome 9.9 ACTC1 KIT
48 testis rhabdomyosarcoma 9.9 DES KIT
49 mannose-binding lectin protein deficiency 9.9 DES KIT
50 lynch syndrome 9.9 CALB2 KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

56 32 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hirsutism 56 32 occasional (7.5%) Occasional (29-5%) HP:0001007
2 ascites 56 32 frequent (33%) Frequent (79-30%) HP:0001541
3 abdominal pain 56 32 hallmark (90%) Very frequent (99-80%) HP:0002027
4 pleural effusion 56 32 hallmark (90%) Very frequent (99-80%) HP:0002202
5 peritonitis 56 32 frequent (33%) Frequent (79-30%) HP:0002586
6 abdominal distention 56 32 hallmark (90%) Very frequent (99-80%) HP:0003270
7 diffuse leiomyomatosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0006756
8 gonadal calcification 56 32 occasional (7.5%) Occasional (29-5%) HP:0008703
9 ovarian fibroma 56 32 hallmark (90%) Very frequent (99-80%) HP:0010618
10 abnormality of the endometrium 56 32 occasional (7.5%) Occasional (29-5%) HP:0030126
11 fibrosarcoma 56 32 occasional (7.5%) Occasional (29-5%) HP:0100244
12 metrorrhagia 56 32 hallmark (90%) Very frequent (99-80%) HP:0100608
13 abnormality of the ovary 56 Very frequent (99-80%)
14 abnormality of circulating hormone level 56 Occasional (29-5%)
15 increased testosterone 56 Occasional (29-5%)
16 increased serum testosterone level 32 occasional (7.5%) HP:0030088

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

39
Ovary

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show all 21)
id Title Authors Year
1
Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma. ( 28693292 )
2017
2
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. ( 27689825 )
2016
3
Imaging Findings of Ovarian Fibrothecoma. ( 26564451 )
2015
4
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. ( 25556284 )
2014
5
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. ( 25635214 )
2014
6
Unilateral ovarian fibrothecoma with menorrhagia. ( 24763236 )
2014
7
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. ( 23431489 )
2013
8
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. ( 22096681 )
2011
9
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. ( 18813938 )
2009
10
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. ( 19329943 )
2009
11
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. ( 19675518 )
2009
12
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. ( 16965622 )
2006
13
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. ( 17415856 )
2004
14
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. ( 14617484 )
2003
15
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. ( 11426907 )
2001
16
Ovarian fibrothecoma with massive edema. ( 11019495 )
2000
17
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. ( 10685524 )
2000
18
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. ( 10836709 )
2000
19
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. ( 7656212 )
1995
20
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. ( 7999713 )
1994
21
Ovarian fibrothecoma: sonographic and histologic findings. ( 1662660 )
1991

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.14 DES KIT
2 10.81 ACTC1 DES
3 10.35 ACTC1 KIT

GO Terms for Ovarian Fibrothecoma

Cellular components related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES KIT

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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