MCID: OVR097
MIFTS: 24

Ovarian Fibrothecoma malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 54
 
Ovarian Thecoma 68

Characteristics:

Orphanet epidemiological data:

54
ovarian fibrothecoma:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet54 ORPHA314478
ICD10 via Orphanet31 D27

Summaries for Ovarian Fibrothecoma

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MalaCards based summary: Ovarian Fibrothecoma, also known as ovarian thecoma, is related to meige syndrome and hypoparathyroidism-intellectual disability-dysmorphism syndrome, and has symptoms including Array, Array and Array. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. Affiliated tissues include ovary.

Related Diseases for Ovarian Fibrothecoma

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Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1meige syndrome29.7ACTC1, DES
2hypoparathyroidism-intellectual disability-dysmorphism syndrome10.1ACTC1, CALB2
3intravascular fasciitis10.1ACTC1, DES
4skin lipoma10.1ACTC1, DES
5lymphangiosarcoma10.1ACTC1, DES
6chondroblastoma10.1ACTC1, DES
7pulmonary venoocclusive disease10.1ACTC1, DES
8mollaret meningitis10.1ACTC1, DES
9malignant glandular tumor of peripheral nerve sheath10.1ACTC1, DES
10pleuropulmonary blastoma type 210.1ACTC1, DES
11skin glomangioma10.1ACTC1, DES
12short-rib thoracic dysplasia 1210.0ACTC1, DES
13t-cell childhood acute lymphocytic leukemia10.0ACTC1, DES
14parovarian cyst10.0ACTC1, DES
15staphyloenterotoxemia10.0ACTC1, DES
16orbit rhabdomyosarcoma10.0ACTC1, DES
17gallbladder leiomyosarcoma10.0ACTC1, DES
18epidural neoplasm9.9ACTC1, DES
19mild phosphoribosylpyrophosphate synthetase superactivity9.9ACTC1, DES
20sublingual gland adenoid cystic carcinoma9.9CALB2, KIT
21ovarian cyst9.9CALB2, KIT
22lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy9.9ACTC1, CALB2
23malignant sertoli-leydig cell tumor9.9CALB2, KIT
24sphenoidal sinus cancer9.9CALB2, KIT
25anus leiomyosarcoma9.9ACTC1, DES
26localized pulmonary fibrosis9.9CALB2, KIT
27megarbane jalkh syndrome9.9ACTC1, DES
28vulvar liposarcoma9.9CALB2, KIT
29longitudinal vaginal septum9.9ACTC1, DES
30lynch syndrome9.9CALB2, KIT
31sialolithiasis9.8ACTC1, KIT
32breast rhabdomyosarcoma9.8DES, KIT
33breast squamous cell carcinoma9.8CALB2, KIT
34intestinal pseudo-obstruction9.8CALB2, KIT
35dysembryoplastic neuroepithelial tumor9.8DES, KIT
36polyomavirus allograft nephropathy9.8ACTC1, KIT
37focal chorioretinitis9.8DES, KIT
38mulibrey nanism9.8
39sarcoma9.8
40retroperitoneal sarcoma9.8
41amenorrhea9.8
42leiomyomatosis9.8
43infertility9.8
44emerinopathy9.8DES, KIT
45familial mitral valve prolapse9.7ACTC1, KIT
46neutrophil immunodeficiency syndrome9.7ACTC1, DES
47ectodermal dysplasia9.7ACTC1, DES
48vulvar sebaceous carcinoma9.7DES, KIT
49ulceroglandular tularemia9.5ACTC1, DES
50pura syndrome9.4ACTC1, DES, KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to ovarian fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

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Human phenotypes related to Ovarian Fibrothecoma:

 54 (show all 15)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the ovary54 Very frequent (99-80%)
2 hirsutism54 Occasional (29-5%)
3 ascites54 Frequent (79-30%)
4 abdominal pain54 Very frequent (99-80%)
5 pleural effusion54 Very frequent (99-80%)
6 peritonitis54 Frequent (79-30%)
7 abnormality of circulating hormone level54 Occasional (29-5%)
8 abdominal distention54 Very frequent (99-80%)
9 diffuse leiomyomatosis54 Occasional (29-5%)
10 gonadal calcification54 Occasional (29-5%)
11 ovarian fibroma54 Very frequent (99-80%)
12 increased testosterone54 Occasional (29-5%)
13 abnormality of the endometrium54 Occasional (29-5%)
14 fibrosarcoma54 Occasional (29-5%)
15 metrorrhagia54 Very frequent (99-80%)

Drugs & Therapeutics for Ovarian Fibrothecoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

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Anatomical Context for Ovarian Fibrothecoma

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MalaCards organs/tissues related to Ovarian Fibrothecoma:

36
Ovary

Publications for Ovarian Fibrothecoma

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Articles related to Ovarian Fibrothecoma:

(show all 20)
idTitleAuthorsYear
1
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. (27689825)
2016
2
Imaging Findings of Ovarian Fibrothecoma. (26564451)
2015
3
Unilateral ovarian fibrothecoma with menorrhagia. (24763236)
2014
4
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. (25635214)
2014
5
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. (25556284)
2014
6
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. (23431489)
2013
7
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. (22096681)
2011
8
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. (19675518)
2009
9
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. (18813938)
2009
10
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. (19329943)
2009
11
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. (16965622)
2006
12
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. (17415856)
2004
13
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. (14617484)
2003
14
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. (11426907)
2001
15
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. (10836709)
2000
16
Ovarian fibrothecoma with massive edema. (11019495)
2000
17
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. (10685524)
2000
18
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. (7656212)
1995
19
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. (7999713)
1994
20
Ovarian fibrothecoma: sonographic and histologic findings. (1662660)
1991

Variations for Ovarian Fibrothecoma

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Expression for genes affiliated with Ovarian Fibrothecoma

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Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for genes affiliated with Ovarian Fibrothecoma

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Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3ACTC1, DES
29.1ACTC1, KIT
39.0DES, KIT

GO Terms for genes affiliated with Ovarian Fibrothecoma

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Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.3ACTC1, DES

Sources for Ovarian Fibrothecoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet