MCID: OVR069
MIFTS: 42

Ovarian Germ Cell Tumor malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Ovarian Germ Cell Tumor

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Ovarian Germ Cell Tumor is related to teratoma and germ cell tumors. An important gene associated with Ovarian Germ Cell Tumor is GATA6 (GATA binding protein 6), and among its related pathways are Notch-mediated HES/HEY network and Heart Development. The compounds nimbolide and 7,12-dimethylbenz(a)anthracene have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Ovarian Germ Cell Tumor

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

ovarian germ cell tumor 43 45 62


Related Diseases for Ovarian Germ Cell Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.4SOX2, POU5F1, NANOG, PDPN, ERVK-6, GATA6
2germ cell tumors11.1
3pediatric ovarian germ cell tumor10.5
4pseudo-meigs syndrome10.5
5meigs syndrome10.5
6growing teratoma syndrome10.4
7malignant germ cell tumor of ovary10.4
8cortical blindness10.2
9teratocarcinoma10.2
10peritonitis10.2
11hemangioendothelioma10.2
12thromboembolism10.2
13testicular germ cell tumor10.2
14blindness10.2
15epithelioid hemangioendothelioma10.2
16atrioventricular septal defect10.1GATA4
17pineoblastoma10.1POU5F1
18tetralogy of fallot10.1GATA6
19endodermal sinus tumor10.1GATA4, GATA6
20germinoma10.1POU5F1, PDPN
21kidney cancer10.1PDPN, TP53
22benign mesothelioma10.1PDPN, TP53
23gallbladder cancer10.1TP53, PDPN
24dysgerminoma10.0POU5F1, BRCA2
25li-fraumeni syndrome10.0TP53, BRCA2
26meningioma10.0PDPN, PCNA
27lynch syndrome10.0TP53, BRCA2
28gestational trophoblastic tumor10.0ERVK-6, PCNA
29malignant pleural mesothelioma10.0PDPN, BIRC5
30adrenocortical carcinoma10.0GATA4, GATA6, TP53
31bladder transitional cell carcinoma10.0BIRC5, TP53
32breast fibroadenoma10.0PCNA, ERVK-6
33papilloma10.0PCNA, TP53
34ductal carcinoma in situ10.0PDPN, BRCA2, TP53
35adenoameloblastoma10.0PCNA, PDPN
36actinic keratosis10.0TP53, PCNA
37male breast cancer10.0BRCA2, PCNA
38cutaneous t cell lymphoma10.0BIRC5, ERVK-6
39breast cancer, invasive ductal10.0PCNA, TP53
40embryonal cancer10.0SOX2, POU5F1, PDPN, GATA4
41benign meningioma10.0PCNA, BIRC5
42cervical cancer10.0BIRC5, PDPN, TP53
43sarcoma10.0ERVK-6, BRCA2, TP53
44b-cell chronic lymphocytic leukemia10.0TP53, BRCA2, BIRC5
45seminoma10.0SOX2, POU5F1, NANOG, PDPN, ERVK-6
46laryngeal benign neoplasm10.0BIRC5, PCNA, TP53
47bladder carcinoma in situ10.0TP53, PCNA, BIRC5
48laryngeal squamous cell carcinoma10.0BIRC5, PCNA, TP53
49oral cancer9.9BIRC5, PCNA, TP53
50transitional cell carcinoma9.9BIRC5, PCNA, TP53

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to ovarian germ cell tumor

Symptoms for Ovarian Germ Cell Tumor

About this section

Drugs & Therapeutics for Ovarian Germ Cell Tumor

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Ovarian Germ Cell Tumor

Search NIH Clinical Center for Ovarian Germ Cell Tumor

Genetic Tests for Ovarian Germ Cell Tumor

About this section

Anatomical Context for Ovarian Germ Cell Tumor

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Ovarian Germ Cell Tumor:

33
Ovary

Animal Models for Ovarian Germ Cell Tumor or affiliated genes

About this section
Sources:
37MGI
See all sources

Publications for Ovarian Germ Cell Tumor

About this section
Sources:
52PubMed
See all sources

Articles related to Ovarian Germ Cell Tumor:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. (24395845)
2014
2
Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. (24412326)
2014
3
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. (23575763)
2013
4
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. (24222875)
2013
5
Updates in the management of ovarian germ cell tumors. (23714505)
2013
6
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. (23406948)
2013
7
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. (23148694)
2013
8
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
9
Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report. (22248255)
2012
10
Molecular genetic analysis of bilateral ovarian germ cell tumors. (23143763)
2012
11
Karyotype result prior to surgery in patients with suspected ovarian germ cell tumors. (21594985)
2011
12
Ovarian germ cell tumors in children: a 20-year retrospective study in a single institution. (21797119)
2011
13
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution. (21988930)
2011
14
Prognostic impact of laterality in malignant ovarian germ cell tumors. (21475076)
2011
15
Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. (21795985)
2011
16
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? (21822906)
2011
17
Bulletin board. Study suggests that following surgery, watchful waiting may be a safe option for girls with early-stage ovarian germ cell tumors. (21188885)
2010
18
Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy. (19878051)
2010
19
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. (19961281)
2010
20
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. (20168245)
2010
21
Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases. (20638529)
2010
22
Malignant ovarian germ cell tumors: a single-institution experience. (19307952)
2009
23
A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome. (19679044)
2009
24
Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. (19483629)
2009
25
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. (19042263)
2008
26
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. (18497549)
2008
27
The influence of conservative surgical practices for malignant ovarian germ cell tumors. (18563734)
2008
28
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)
2007
29
Survivin expression in ovarian germ cell tumors]. (17441339)
2007
30
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. (17602084)
2007
31
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. (17048439)
2006
32
Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: correlation with the cell proliferation activity and clinicopathologic features. (17016588)
2006
33
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. (16578998)
2006
34
Growing teratoma syndrome after ovarian germ cell tumors. (16946208)
2006
35
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. (16623016)
2005
36
Trisomy 14pter --> q21: a case with associated ovarian germ cell tumor and review of the literature. (15211663)
2004
37
Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. (10533299)
1999
38
A case of pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9841228)
1998
39
Cytogenetics of a malignant ovarian germ-cell tumor. (9650555)
1998
40
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9299274)
1997
41
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). (8908168)
1996
42
Overexpression or mutation of the p53 tumor suppressor gene does not occur in malignant ovarian germ cell tumors. (8625105)
1995
43
Radiological case of the month. Malignant ovarian germ cell tumor. (8395763)
1993
44
Ovarian germ cell tumor evolving to myelodysplasia. (7692949)
1993
45
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. (2253191)
1990
46
Glycopeptides from murine teratocarcinoma cells: structure of the determinants recognised by Griffonia simplicifolia agglutinin I and by sera from patients with ovarian germ cell tumors. (2458180)
1988
47
A canine ovarian germ cell tumor with extraembryonic differentiation. (3029938)
1987
48
Mixed ovarian germ cell tumor in 46,X, +mar Turner's syndrome: a case report. (6525086)
1984
49
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. (6203815)
1984
50
Malignant mixed ovarian germ cell tumor. (6283329)
1982

Variations for Ovarian Germ Cell Tumor

About this section

Expression for genes affiliated with Ovarian Germ Cell Tumor

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Germ Cell Tumor.

Pathways for genes affiliated with Ovarian Germ Cell Tumor

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 55Reactome, 30KEGG, 5Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GATA6, GATA4
29.9GATA4, GATA6
39.7BRCA2, BIRC5
49.6BIRC5, TP53
59.5TP53, PCNA
69.5PCNA, TP53
79.5PCNA, TP53
89.4TP53, GATA6, GATA4
99.2BIRC5, BRCA2, TP53
109.2SOX2, POU5F1, NANOG
119.2NANOG, POU5F1, SOX2
129.2NANOG, POU5F1, SOX2
13
Show member pathways
9.1PCNA, BRCA2, TP53
14
Show member pathways
9.1PCNA, BRCA2, TP53
159.1TP53, BRCA2, PCNA
169.1PCNA, BRCA2, TP53
17
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1BIRC5, PCNA, TP53
18
Show member pathways
Signal transduction PTEN pathway60
9.1BIRC5, PCNA, TP53
198.9SOX2, POU5F1, NANOG, GATA6
20
Show member pathways
8.9GATA4, BIRC5, BRCA2, TP53
218.9SOX2, POU5F1, NANOG, GATA4
22
Show member pathways
8.9SOX2, POU5F1, NANOG, GATA4
238.8TP53, SOX2, POU5F1, NANOG
24
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.8NANOG, POU5F1, SOX2, TP53
258.6GATA4, GATA6, NANOG, POU5F1, SOX2

Compounds for genes affiliated with Ovarian Germ Cell Tumor

About this section
Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB
See all sources

Compounds related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1nimbolide459.9PCNA, BIRC5
27,12-dimethylbenz(a)anthracene459.9BIRC5, BRCA2
3norcantharidin459.8BIRC5, PCNA
4acridine459.8PCNA, BIRC5
53,3-diindolylmethane459.8BIRC5, TP53
6daidzein459.7BRCA2, BIRC5
78-oxoguanine459.7BRCA2, PCNA
8rofecoxib45 51 29 1112.7PCNA, BIRC5
9indole-3-carbinol459.7TP53, BRCA2, BIRC5
10vincristine45 51 1111.6BIRC5, BRCA2, TP53
118-oxo-dg459.6TP53, PCNA
12adriamycin459.6TP53, BRCA2, BIRC5
13o6-methylguanine459.6PCNA, BRCA2, TP53
14methylmethanesulfonate459.5PCNA, BRCA2, TP53
15docetaxel45 51 61 1112.5TP53, BRCA2, BIRC5
16dutp459.5TP53, PCNA, BIRC5
17sulindac45 1110.5TP53, PCNA, BIRC5
18roscovitine459.5TP53, PCNA, BIRC5
19hydroxyurea45 51 1111.5PCNA, BRCA2, TP53
20gemcitabine45 51 1111.4TP53, PCNA, BIRC5
21olomoucine45 1110.4TP53, PCNA
22mg 13245 6110.4BIRC5, PCNA, TP53
23curcumin459.3ERVK-6, BIRC5, TP53
245-aza-2deoxycytidine459.3GATA4, GATA6, PCNA, TP53
25arsenite45 2410.3TP53, PCNA, BIRC5
26butyrate459.2GATA6, BIRC5, PCNA, TP53
27vitamin a45 24 1111.2BIRC5, GATA6, GATA4
28adpribose459.2TP53, BRCA2, PCNA, BIRC5
29mitomycin c459.2BIRC5, PCNA, BRCA2, TP53
30resveratrol45 61 24 1112.2TP53, BRCA2, PCNA, BIRC5
31camptothecin45 61 1111.1BIRC5, PCNA, BRCA2, TP53
32etoposide45 51 61 1112.1BIRC5, PCNA, BRCA2, TP53
33guanine45 24 1111.1ERVK-6, BIRC5, TP53
34tamoxifen45 51 29 1112.1TP53, BRCA2, PCNA, BIRC5
35paclitaxel45 51 1111.1BIRC5, PCNA, BRCA2, TP53
36gold459.1BRCA2, PDPN, ERVK-6
37zinc45 2410.0SOX2, BRCA2, ERVK-6, GATA6, GATA4
38cisplatin45 51 61 1112.0BIRC5, PCNA, BRCA2, TP53
39thymidylate459.0TP53, PCNA, BIRC5, ERVK-6
40egcg459.0TP53, PCNA, BIRC5, ERVK-6
41steroid458.9BRCA2, BIRC5, ERVK-6, GATA6, GATA4
42progesterone45 29 61 24 1112.8TP53, BRCA2, PCNA, BIRC5, GATA4
43h2o2458.8TP53, BRCA2, PCNA, BIRC5, GATA4
44testosterone45 61 24 1111.7BRCA2, PCNA, BIRC5, ERVK-6, GATA4
45thymidine45 249.6TP53, BRCA2, PCNA, BIRC5, ERVK-6
46oligonucleotide458.3TP53, BRCA2, PCNA, BIRC5, ERVK-6, GATA4
47estrogen458.3TP53, BRCA2, PCNA, BIRC5, ERVK-6, GATA4
48vegf458.3TP53, POU5F1, PCNA, PDPN, BIRC5
49paraffin457.8TP53, BRCA2, PCNA, PDPN, BIRC5, ERVK-6
50retinoic acid45 248.4GATA4, TP53, SOX2, POU5F1, BRCA2, PCNA

GO Terms for genes affiliated with Ovarian Germ Cell Tumor

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2GATA6, POU5F1, SOX2
2nucleoplasmGO:0056547.6GATA4, TP53, POU5F1, BRCA2, NANOG, PCNA
3nucleolusGO:0057307.6TP53, SOX2, BRCA2, NANOG, PCNA, ERVK-6
4cytoplasmGO:0057377.5SOX2, POU5F1, BRCA2, PCNA, BIRC5, ERVK-6
5nucleusGO:0056346.8TP53, SOX2, POU5F1, BRCA2, NANOG, PCNA

Biological processes related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1intestinal epithelial cell differentiationGO:06057510.2GATA6, GATA4
2positive regulation of cardioblast differentiationGO:05189110.2GATA6, GATA4
3response to growth factorGO:07084810.2GATA6, SOX2
4cardiac muscle hypertrophy in response to stressGO:01489810.2GATA4, GATA6
5positive regulation of cardiac muscle cell proliferationGO:06004510.1GATA4, GATA6
6positive regulation of cell cycle arrestGO:07115810.0GATA6, TP53
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9BRCA2, TP53
8response to X-rayGO:0101659.9BRCA2, TP53
9response to estrogenGO:0436279.9GATA4, GATA6
10cell agingGO:0075699.8BRCA2, TP53
11response to woundingGO:0096119.8POU5F1, SOX2
12response to gamma radiationGO:0103329.8BRCA2, TP53
13intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.8TP53, BRCA2
14tube morphogenesisGO:0352399.7GATA6, PDPN
15in utero embryonic developmentGO:0017019.6TP53, GATA6, GATA4
16endodermal cell fate specificationGO:0017149.6NANOG, POU5F1, SOX2
17somatic stem cell maintenanceGO:0350199.6NANOG, POU5F1, SOX2
18regulation of gene expressionGO:0104689.6SOX2, POU5F1, NANOG
19base-excision repairGO:0062849.6TP53, PCNA
20nucleotide-excision repairGO:0062899.5PCNA, BRCA2, TP53
21lung alveolus developmentGO:0482869.5PDPN, SOX2
22response to retinoic acidGO:0325269.5NANOG, SOX2
23positive regulation of mitotic cell cycleGO:0459319.4BRCA2, NANOG, BIRC5
24cytokinesisGO:0009109.4BIRC5, BRCA2
25positive regulation of transcription, DNA-templatedGO:0458939.3TP53, SOX2, BRCA2, GATA4
26negative regulation of transcription from RNA polymerase II promoterGO:0001229.1TP53, SOX2, NANOG, GATA6
27regulation of transcription, DNA-templatedGO:0063558.7TP53, SOX2, POU5F1, NANOG, GATA4
28positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TP53, SOX2, POU5F1, NANOG, GATA6, GATA4
29cell proliferationGO:0082838.4TP53, NANOG, PCNA, PDPN

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:03519810.0POU5F1, SOX2
2enhancer sequence-specific DNA bindingGO:0011589.6GATA4, NANOG
3chaperone bindingGO:0510879.6BIRC5, TP53
4RNA polymerase II core promoter sequence-specific DNA bindingGO:0009799.4GATA6, TP53
5receptor tyrosine kinase bindingGO:0309719.4TP53, PCNA
6transcription factor bindingGO:0081349.3TP53, POU5F1, GATA6, GATA4
7transcription regulatory region DNA bindingGO:0442129.0GATA4, GATA6, POU5F1, SOX2, TP53
8chromatin bindingGO:0036828.7TP53, SOX2, NANOG, GATA6, GATA4
9zinc ion bindingGO:0082708.6TP53, BIRC5, ERVK-6, GATA6, GATA4
10sequence-specific DNA binding transcription factor activityGO:0037008.4TP53, SOX2, POU5F1, NANOG, GATA6, GATA4
11DNA bindingGO:0036778.1TP53, SOX2, POU5F1, NANOG, ERVK-6, GATA4
12protein bindingGO:0055157.5TP53, SOX2, POU5F1, BRCA2, PCNA, BIRC5

Products for genes affiliated with Ovarian Germ Cell Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ovarian Germ Cell Tumor

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet