MCID: OVR069
MIFTS: 40

Ovarian Germ Cell Tumor malady

Cancer category

Summaries for Ovarian Germ Cell Tumor

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33MalaCards
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MalaCards: Ovarian Germ Cell Tumor is related to teratoma and peritoneal carcinoma. An important gene associated with Ovarian Germ Cell Tumor is GATA6 (GATA binding protein 6), and among its related pathways are FOXM1 transcription factor network and Aurora A signaling. The compounds estrogen and etoposide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Ovarian Germ Cell Tumor

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

ovarian germ cell tumor 43 45 61


Related Diseases for Ovarian Germ Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the ovarian germ cell malignant tumor family:

ovarian germ cell tumor

Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.5NANOG, POU5F1, GATA6, GATA4, PDPN, SOX2
2peritoneal carcinoma30.3BRCA2
3germ cell tumors11.0
4ovarian germ cell malignant tumor10.9
5malignant germ cell tumor10.9
6mixed germ cell tumor10.5
7testicular germ cell tumor10.5
8pseudo-meigs syndrome10.5
9meigs syndrome10.5
10germ cell cancer10.4
11growing teratoma syndrome10.4
12teratocarcinoma10.2
13cortical blindness10.2
14turner syndrome10.2
15hemangioendothelioma10.2
16thromboembolism10.2
17blindness10.2
18epithelioid hemangioendothelioma10.2
19pancreatitis10.0BRCA2
20cervical intraepithelial neoplasia10.0BIRC5
21breast-ovarian cancer, familial, 210.0BRCA2
22esophageal cancer10.0TP53
23leukoplakia10.0PCNA
24neuroblastoma10.0TP53
25myeloid leukemia10.0BIRC5
26brain cancer10.0TP53
27bilateral breast cancer10.0BRCA2
28atrioventricular septal defect10.0GATA4
29pineoblastoma10.0POU5F1
30tetralogy of fallot10.0GATA6, GATA4
31endodermal sinus tumor10.0GATA6, GATA4
32hepatoblastoma10.0BIRC5
33benign meningioma10.0PCNA, BIRC5
34osteosarcoma10.0TP53, BIRC5
35medulloblastoma10.0BRCA2, TP53
36malignant mesothelioma10.0PDPN
37psoriasis10.0POU5F1
38sarcoma10.0BRCA2, TP53
39male breast cancer10.0PCNA, BRCA2
40gonadoblastoma10.0POU5F1
41astrocytoma10.0TP53, PCNA
42papilloma10.0TP53, PCNA
43skin cancer10.0TP53, PCNA
44bladder transitional cell carcinoma10.0TP53, BIRC5
45familial adenomatous polyposis10.0BIRC5, TP53
46li-fraumeni syndrome10.0TP53, BRCA2
47oligodendroglioma10.0TP53, PCNA
48ataxia telangiectasia10.0TP53, BRCA2
49breast cancer, invasive ductal10.0TP53, PCNA
50adrenocortical carcinoma10.0GATA4, GATA6, TP53

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to ovarian germ cell tumor

Clinical Features for Ovarian Germ Cell Tumor

Drugs & Therapeutics for Ovarian Germ Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ovarian Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Ovarian Germ Cell Tumor

Search NIH Clinical Center for Ovarian Germ Cell Tumor

Search CenterWatch for Ovarian Germ Cell Tumor

Genetic Tests for Ovarian Germ Cell Tumor

Anatomical Context for Ovarian Germ Cell Tumor

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33MalaCards
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MalaCards organs/tissues related to Ovarian Germ Cell Tumor:

33
Small intestine, Liver, Lung, Breast, Ovary, T cells, Pancreatic islet

Animal Models for Ovarian Germ Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Ovarian Germ Cell Tumor

Sources:
51PubMed
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Articles related to Ovarian Germ Cell Tumor:

(show top 50)    (show all 90)
idTitleAuthorsYear
1
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. (24222875)
2013
2
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. (23406948)
2013
3
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. (23148694)
2013
4
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
5
Ovarian mixed germ cell tumor with yolk sac and teratomatous components in a dog. (23604259)
2013
6
Malignant ovarian germ cell tumors: presentation, survival and second cancer in a population based Norwegian cohort (1953-2009). (24001518)
2013
7
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. (24376332)
2013
8
Long-term oncological and reproductive outcomes of fertility-sparing cytoreductive surgery in females aged 25 years and younger with malignant ovarian germ cell tumors. (24320102)
2013
9
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. (22734844)
2012
10
Treatment of malignant ovarian germ cell tumors and preservation of fertility. (23185794)
2012
11
Karyotype result prior to surgery in patients with suspected ovarian germ cell tumors. (21594985)
2011
12
Prognostic impact of laterality in malignant ovarian germ cell tumors. (21475076)
2011
13
Unusual liver locations of growing teratoma syndrome in ovarian malignant germ cell tumors. (24371596)
2011
14
Malignant mixed ovarian germ cell tumor with embryonal component. (20869284)
2011
15
Bulletin board. Study suggests that following surgery, watchful waiting may be a safe option for girls with early-stage ovarian germ cell tumors. (21188885)
2010
16
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. (20168245)
2010
17
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. (19636015)
2009
18
Malignant ovarian germ cell tumors: a single-institution experience. (19307952)
2009
19
Ovarian stromal and germ cell tumors. (19332247)
2009
20
SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. (19295406)
2009
21
Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. (19483629)
2009
22
Bowel loop in an ovarian tumor: grossly visible, completely developed intestinal loop in mature cystic teratoma of malignant mixed germ cell tumor. (19563411)
2009
23
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. (19042263)
2008
24
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. (18497549)
2008
25
The influence of conservative surgical practices for malignant ovarian germ cell tumors. (18563734)
2008
26
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)
2007
27
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. (17048439)
2006
28
Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: correlation with the cell proliferation activity and clinicopathologic features. (17016588)
2006
29
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. (16578998)
2006
30
Growing teratoma syndrome after ovarian germ cell tumors. (16946208)
2006
31
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. (11781529)
2002
32
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. (10849320)
2000
33
Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. (10533299)
1999
34
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review. (9702861)
1998
35
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9299274)
1997
36
Secondary ANLL with t(11;19)(q23;p13) following etoposide and cisplatin for ovarian germ cell tumor. (9491667)
1997
37
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). (8908168)
1996
38
Overexpression or mutation of the p53 tumor suppressor gene does not occur in malignant ovarian germ cell tumors. (8625105)
1995
39
Radiological case of the month. Malignant ovarian germ cell tumor. (8395763)
1993
40
Ovarian germ cell tumor evolving to myelodysplasia. (7692949)
1993
41
Serum AFP, hCG and CEA in the management of patients with testicular, ovarian and extragonadal germ cell tumors. (1378875)
1992
42
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. (1849112)
1991
43
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. (2253191)
1990
44
Etoposide combination chemotherapy in refractory ovarian malignant germ cell tumor. (2227584)
1990
45
Glycopeptides from murine teratocarcinoma cells: structure of the determinants recognised by Griffonia simplicifolia agglutinin I and by sera from patients with ovarian germ cell tumors. (2458180)
1988
46
A canine ovarian germ cell tumor with extraembryonic differentiation. (3029938)
1987
47
A rare malignant ovarian mixed germ cell tumor containing pancreatic tissue with islet cells. (6092290)
1984
48
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. (6203815)
1984
49
Malignant mixed ovarian germ cell tumor. (6283329)
1982
50
Ovarian extraembryonal teratoma. II. Endodermal sinus tumor mixed with other germ cell tumors. (189611)
1977

Genetic Variations for Ovarian Germ Cell Tumor

Expression for genes affiliated with Ovarian Germ Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Germ Cell Tumor.

Pathways for genes affiliated with Ovarian Germ Cell Tumor

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8BIRC5, BRCA2
29.7BIRC5, TP53
3
Hide members
9.5PCNA, BRCA2
49.4TP53, GATA6, GATA4
59.4PCNA, TP53
6
Hide members
9.4TP53, GATA4, BRCA2
7
Hide members
9.1TP53, BIRC5, PCNA
8
Hide members
9.1PCNA, BIRC5, TP53
9
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.1TP53, PCNA, BRCA2
109.1BRCA2, PCNA, TP53
118.7NANOG, POU5F1, SOX2
128.7NANOG, POU5F1, SOX2
138.7SOX2, POU5F1, NANOG
148.4SOX2, GATA6, POU5F1, NANOG
15
Hide members
8.4SOX2, GATA4, POU5F1, NANOG
168.4NANOG, POU5F1, GATA4, SOX2
17
Hide members
8.3TP53, NANOG, POU5F1, SOX2
188.3SOX2, POU5F1, NANOG, TP53
198.1NANOG, POU5F1, GATA6, GATA4, SOX2

Compounds for genes affiliated with Ovarian Germ Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5GATA4
2etoposide45 50 60 1113.5BRCA2
3adriamycin4510.5BIRC5
4vincristine45 50 1112.5BRCA2
57,12-dimethylbenz(a)anthracene4510.1BIRC5, BRCA2
6daidzein4510.0BRCA2, BIRC5
73,3-diindolylmethane4510.0BIRC5, TP53
8nimbolide459.9BIRC5, PCNA
9norcantharidin459.9BIRC5, PCNA
10acridine459.8PCNA, BIRC5
11rofecoxib45 50 29 1112.8PCNA, BIRC5
12indole-3-carbinol459.8BRCA2, BIRC5, TP53
13paclitaxel45 50 1111.7BRCA2, BIRC5, TP53
148-oxoguanine459.7BRCA2, PCNA
15hoechst 33342459.7BIRC5, PCNA
16olomoucine45 1110.7PCNA, TP53
17docetaxel45 50 60 1112.7TP53, BIRC5, BRCA2
188-oxo-dg459.7PCNA, TP53
19sulindac sulfide459.6PCNA, TP53
20vitamin a45 11 2411.6GATA4, GATA6, BIRC5
21temozolomide45 1110.6PCNA, TP53
22sulindac45 1110.5PCNA, BIRC5, TP53
23dutp459.5PCNA, BIRC5, TP53
24roscovitine459.5TP53, BIRC5, PCNA
25o6-methylguanine459.5TP53, PCNA, BRCA2
26methylmethanesulfonate459.5BRCA2, PCNA, TP53
27gemcitabine45 50 1111.5TP53, BIRC5, PCNA
28thymidylate459.5TP53, BIRC5, PCNA
29hydroxyurea45 50 1111.5BRCA2, PCNA, TP53
30mg 13245 6010.4TP53, BIRC5, PCNA
31taxane459.4TP53, BIRC5
32arsenite45 2410.4TP53, BIRC5, PCNA
33lycopene45 2410.4PCNA, BRCA2
345-aza-2deoxycytidine459.3GATA4, GATA6, PCNA, TP53
35adpribose459.2BRCA2, PCNA, BIRC5, TP53
36mitomycin c459.2TP53, BIRC5, PCNA, BRCA2
37resveratrol45 60 11 2412.2BRCA2, PCNA, BIRC5, TP53
38camptothecin45 60 1111.2BRCA2, PCNA, BIRC5, TP53
39methotrexate45 50 1111.1BRCA2, PCNA, BIRC5
40tamoxifen45 50 29 1112.1TP53, BIRC5, PCNA, BRCA2
415fluorouracil459.1TP53, BIRC5, PCNA
42cisplatin45 50 60 1112.1TP53, BIRC5, PCNA, BRCA2
43thymidine45 2410.1BRCA2, PCNA, BIRC5, TP53
44testosterone45 60 11 2412.0BRCA2, GATA4, PCNA, BIRC5
45progesterone45 60 29 11 2412.8TP53, BIRC5, PCNA, GATA4, BRCA2
46h2o2458.8BRCA2, GATA4, PCNA, BIRC5, TP53
47oligonucleotide458.8BRCA2, GATA4, PCNA, BIRC5, TP53
48paraffin458.6TP53, BIRC5, PCNA, PDPN, BRCA2
49vegf458.4PDPN, POU5F1, PCNA, BIRC5, TP53
50retinoic acid45 248.6TP53, BRCA2, SOX2, GATA4, GATA6, POU5F1

GO Terms for genes affiliated with Ovarian Germ Cell Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2POU5F1, GATA6, SOX2
2nucleoplasmGO:0056547.0TP53, BRCA2, GATA4, GATA6, POU5F1, PCNA
3nucleusGO:0056346.0TP53, BRCA2, SOX2, BIRC5, NANOG, PCNA

Biological processes related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cardioblast differentiationGO:05189110.2GATA6, GATA4
2intestinal epithelial cell differentiationGO:06057510.2GATA6, GATA4
3cardiac muscle hypertrophy in response to stressGO:01489810.1GATA4, GATA6
4positive regulation of cardiac muscle cell proliferationGO:06004510.1GATA6, GATA4
5response to growth factor stimulusGO:07084810.0SOX2, GATA6
6positive regulation of cell cycle arrestGO:07115810.0TP53, GATA6
7tube morphogenesisGO:03523910.0PDPN, GATA6
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.0TP53, BRCA2
9response to X-rayGO:0101659.9BRCA2, TP53
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.8TP53, BRCA2
11cell agingGO:0075699.8TP53, BRCA2
12response to gamma radiationGO:0103329.7BRCA2, TP53
13base-excision repairGO:0062849.4TP53, PCNA
14nucleotide-excision repairGO:0062899.4BRCA2, PCNA, TP53
15in utero embryonic developmentGO:0017019.3TP53, GATA6, GATA4
16positive regulation of mitotic cell cycleGO:0459319.3BRCA2, NANOG, BIRC5
17lung alveolus developmentGO:0482869.2PDPN, SOX2
18positive regulation of transcription, DNA-dependentGO:0458939.2BRCA2, SOX2, GATA4, TP53
19endodermal cell fate specificationGO:0017149.0NANOG, POU5F1, SOX2
20somatic stem cell maintenanceGO:0350199.0NANOG, POU5F1, SOX2
21regulation of gene expressionGO:0104689.0NANOG, POU5F1, SOX2
22negative regulation of transcription from RNA polymerase II promoterGO:0001228.7TP53, NANOG, GATA6, SOX2
23cell proliferationGO:0082838.4TP53, NANOG, PCNA, PDPN
24regulation of transcription, DNA-dependentGO:0063558.1SOX2, GATA4, POU5F1, NANOG, TP53
25positive regulation of transcription from RNA polymerase II promoterGO:0459448.0SOX2, GATA4, GATA6, POU5F1, NANOG, TP53

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.5POU5F1, SOX2
2enhancer sequence-specific DNA bindingGO:0011589.2GATA4, NANOG
3receptor tyrosine kinase bindingGO:0309719.1TP53, PCNA
4transcription factor bindingGO:0081349.0GATA4, GATA6, POU5F1, TP53
5transcription regulatory region DNA bindingGO:0442128.6TP53, POU5F1, GATA6, GATA4, SOX2
6chromatin bindingGO:0036828.3SOX2, GATA4, GATA6, NANOG, TP53
7sequence-specific DNA binding transcription factor activityGO:0037007.8SOX2, GATA4, GATA6, POU5F1, NANOG, TP53
8protein bindingGO:0055157.1SOX2, GATA4, GATA6, POU5F1, PCNA, BIRC5

Products for genes affiliated with Ovarian Germ Cell Tumor

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Sources for Ovarian Germ Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet