MCID: OVR069
MIFTS: 43

Ovarian Germ Cell Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Ovarian Germ Cell Tumor

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MalaCards based summary: Ovarian Germ Cell Tumor is related to teratoma and germ cell tumors. An important gene associated with Ovarian Germ Cell Tumor is GATA6 (GATA binding protein 6), and among its related pathways are Notch-mediated HES/HEY network and Heart Development. The compounds nimbolide and 7,12-dimethylbenz(a)anthracene have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Ovarian Germ Cell Tumor

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
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Ovarian Germ Cell Tumor, Aliases & Descriptions:

Name: Ovarian Germ Cell Tumor 42 44 62


Classifications:

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Global: Rare diseases, Cancer diseases


Related Diseases for Ovarian Germ Cell Tumor

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Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.1SOX2, POU5F1, NANOG, PDPN, ERVK-6, GATA4
2germ cell tumors11.2
3pediatric ovarian germ cell tumor10.6
4growing teratoma syndrome10.5
5pseudo-meigs syndrome10.5
6atrioventricular septal defect10.4GATA4
7pineoblastoma10.4POU5F1
8tetralogy of fallot10.4GATA6
9endodermal sinus tumor10.3GATA4, GATA6
10germinoma10.3POU5F1, PDPN
11kidney cancer10.3PDPN, TP53
12cortical blindness10.3
13teratocarcinoma10.3
14gonadal dysgenesis10.3
15peritonitis10.3
16hemangioendothelioma10.3
17thromboembolism10.3
18testicular germ cell tumor10.3
19blindness10.3
20epithelioid hemangioendothelioma10.3
21benign mesothelioma10.2TP53, PDPN
22gallbladder cancer10.2PDPN, TP53
23dysgerminoma10.2BRCA2, POU5F1
24li-fraumeni syndrome10.2BRCA2, TP53
25meningioma10.2PDPN, PCNA
26lynch syndrome10.2BRCA2, TP53
27gestational trophoblastic tumor10.2ERVK-6, PCNA
28malignant pleural mesothelioma10.1BIRC5, PDPN
29adrenocortical carcinoma10.1TP53, GATA6, GATA4
30bladder transitional cell carcinoma10.1TP53, BIRC5
31breast fibroadenoma10.1ERVK-6, PCNA
32papilloma10.1PCNA, TP53
33ductal carcinoma in situ10.1PDPN, BRCA2, TP53
34ameloblastoma10.1PCNA, PDPN
35male breast cancer10.1BRCA2, PCNA
36actinic keratosis10.1TP53, PCNA
37cutaneous t cell lymphoma10.0ERVK-6, BIRC5
38breast cancer, invasive ductal10.0PCNA, TP53
39embryonal cancer10.0GATA4, PDPN, SOX2, POU5F1
40benign meningioma10.0PCNA, BIRC5
41cervical cancer9.9PDPN, BIRC5, TP53
42sarcoma9.9BRCA2, TP53, ERVK-6
43chronic lymphocytic leukemia9.9TP53, BRCA2, BIRC5
44seminoma9.9SOX2, POU5F1, NANOG, PDPN, ERVK-6
45laryngeal benign neoplasm9.8TP53, PCNA, BIRC5
46bladder carcinoma in situ9.8TP53, PCNA, BIRC5
47laryngeal squamous cell carcinoma9.8BIRC5, TP53, PCNA
48oral cancer9.8BIRC5, TP53, PCNA
49transitional cell carcinoma9.8TP53, PCNA, BIRC5
50endometrial carcinoma9.8TP53, PCNA, BRCA2

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to ovarian germ cell tumor

Symptoms for Ovarian Germ Cell Tumor

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Drugs & Therapeutics for Ovarian Germ Cell Tumor

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Drug clinical trials:

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Genetic Tests for Ovarian Germ Cell Tumor

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Anatomical Context for Ovarian Germ Cell Tumor

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MalaCards organs/tissues related to Ovarian Germ Cell Tumor:

32
Ovary

Animal Models for Ovarian Germ Cell Tumor or affiliated genes

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Publications for Ovarian Germ Cell Tumor

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Articles related to Ovarian Germ Cell Tumor:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. (24395845)
2014
2
Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. (24412326)
2014
3
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. (24681864)
2014
4
Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors. (25341580)
2014
5
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. (23575763)
2013
6
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. (24222875)
2013
7
Updates in the management of ovarian germ cell tumors. (23714505)
2013
8
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? (24475592)
2013
9
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. (23406948)
2013
10
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. (23148694)
2013
11
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
12
Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report. (22248255)
2012
13
Molecular genetic analysis of bilateral ovarian germ cell tumors. (23143763)
2012
14
Karyotype result prior to surgery in patients with suspected ovarian germ cell tumors. (21594985)
2011
15
Ovarian germ cell tumors in children: a 20-year retrospective study in a single institution. (21797119)
2011
16
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution. (21988930)
2011
17
Prognostic impact of laterality in malignant ovarian germ cell tumors. (21475076)
2011
18
Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. (21795985)
2011
19
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? (21822906)
2011
20
Bulletin board. Study suggests that following surgery, watchful waiting may be a safe option for girls with early-stage ovarian germ cell tumors. (21188885)
2010
21
Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy. (19878051)
2010
22
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. (19961281)
2010
23
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. (20168245)
2010
24
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. (19636015)
2009
25
Malignant ovarian germ cell tumors: a single-institution experience. (19307952)
2009
26
A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome. (19679044)
2009
27
Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. (19483629)
2009
28
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. (19042263)
2008
29
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. (18497549)
2008
30
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)
2007
31
Survivin expression in ovarian germ cell tumors]. (17441339)
2007
32
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. (17602084)
2007
33
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. (17048439)
2006
34
Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: correlation with the cell proliferation activity and clinicopathologic features. (17016588)
2006
35
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. (16578998)
2006
36
Growing teratoma syndrome after ovarian germ cell tumors. (16946208)
2006
37
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. (16623016)
2005
38
Trisomy 14pter --> q21: a case with associated ovarian germ cell tumor and review of the literature. (15211663)
2004
39
Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. (10533299)
1999
40
A case of pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9841228)
1998
41
Cytogenetics of a malignant ovarian germ-cell tumor. (9650555)
1998
42
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9299274)
1997
43
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). (8908168)
1996
44
Overexpression or mutation of the p53 tumor suppressor gene does not occur in malignant ovarian germ cell tumors. (8625105)
1995
45
Radiological case of the month. Malignant ovarian germ cell tumor. (8395763)
1993
46
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. (2253191)
1990
47
Glycopeptides from murine teratocarcinoma cells: structure of the determinants recognised by Griffonia simplicifolia agglutinin I and by sera from patients with ovarian germ cell tumors. (2458180)
1988
48
A canine ovarian germ cell tumor with extraembryonic differentiation. (3029938)
1987
49
Mixed ovarian germ cell tumor in 46,X, +mar Turner's syndrome: a case report. (6525086)
1984
50
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. (6203815)
1984

Variations for Ovarian Germ Cell Tumor

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Expression for genes affiliated with Ovarian Germ Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Ovarian Germ Cell Tumor

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Pathways for genes affiliated with Ovarian Germ Cell Tumor

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Pathways related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GATA6, GATA4
29.9GATA4, GATA6
39.7BRCA2, BIRC5
49.6TP53, BIRC5
59.5PCNA, TP53
69.5PCNA, TP53
79.5TP53, PCNA
89.4TP53, GATA6, GATA4
99.2TP53, BRCA2, BIRC5
109.2POU5F1, NANOG, SOX2
119.2POU5F1, SOX2, NANOG
129.2NANOG, SOX2, POU5F1
13
Show member pathways
9.1PCNA, BRCA2, TP53
14
Show member pathways
9.1PCNA, TP53, BRCA2
159.1TP53, BRCA2, PCNA
169.1PCNA, BRCA2, TP53
17
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1TP53, PCNA, BIRC5
18
Show member pathways
Signal transduction PTEN pathway60
9.1PCNA, TP53, BIRC5
198.9SOX2, POU5F1, NANOG, GATA6
20
Show member pathways
8.9TP53, BRCA2, BIRC5, GATA4
218.9SOX2, POU5F1, NANOG, GATA4
22
Show member pathways
8.9NANOG, GATA4, POU5F1, SOX2
238.8POU5F1, SOX2, TP53, NANOG
24
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.8SOX2, NANOG, TP53, POU5F1
258.6GATA4, GATA6, SOX2, POU5F1, NANOG

Compounds for genes affiliated with Ovarian Germ Cell Tumor

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Compounds related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1nimbolide449.9PCNA, BIRC5
27,12-dimethylbenz(a)anthracene449.9BRCA2, BIRC5
3norcantharidin449.8BIRC5, PCNA
4acridine449.8PCNA, BIRC5
53,3-diindolylmethane449.8BIRC5, TP53
6rofecoxib44 50 28 1112.7PCNA, BIRC5
7indole-3-carbinol449.7BIRC5, TP53, BRCA2
88-oxo-dg449.6TP53, PCNA
9daidzein449.6BRCA2, BIRC5
108-oxoguanine449.6BRCA2, PCNA
11vincristine44 50 1111.6BIRC5, TP53, BRCA2
12olomoucine44 1110.6PCNA, TP53
13adriamycin449.6BIRC5, TP53, BRCA2
14o6-methylguanine449.6PCNA, TP53, BRCA2
15methylmethanesulfonate449.5PCNA, BRCA2, TP53
16docetaxel44 50 61 1112.5BIRC5, TP53, BRCA2
17dutp449.5BIRC5, PCNA, TP53
18sulindac44 1110.5TP53, PCNA, BIRC5
19roscovitine449.5TP53, PCNA, BIRC5
20hydroxyurea44 50 1111.5BRCA2, PCNA, TP53
21gemcitabine44 50 1111.4PCNA, TP53, BIRC5
22mg 13244 6110.4TP53, BIRC5, PCNA
23curcumin449.3ERVK-6, TP53, BIRC5
245-aza-2deoxycytidine449.3PCNA, TP53, GATA6, GATA4
25arsenite44 2410.3BIRC5, PCNA, TP53
26butyrate449.2BIRC5, GATA6, PCNA, TP53
27vitamin a44 24 1111.2GATA4, GATA6, BIRC5
28adpribose449.2TP53, BRCA2, PCNA, BIRC5
29mitomycin c449.2TP53, PCNA, BIRC5, BRCA2
30resveratrol44 61 24 1112.2BIRC5, TP53, BRCA2, PCNA
31camptothecin44 61 1111.1PCNA, BIRC5, BRCA2, TP53
32etoposide44 50 61 1112.1BRCA2, PCNA, BIRC5, TP53
33guanine44 24 1111.1ERVK-6, TP53, BIRC5
34tamoxifen44 50 28 1112.1PCNA, TP53, BRCA2, BIRC5
35paclitaxel44 50 1111.1BIRC5, PCNA, TP53, BRCA2
36gold449.1BRCA2, PDPN, ERVK-6
37zinc44 2410.0ERVK-6, BRCA2, SOX2, GATA6, GATA4
38cisplatin44 50 61 1112.0BIRC5, TP53, BRCA2, PCNA
39thymidylate449.0ERVK-6, BIRC5, PCNA, TP53
40egcg449.0PCNA, ERVK-6, BIRC5, TP53
41steroid448.9GATA4, GATA6, ERVK-6, BRCA2, BIRC5
42progesterone44 28 61 24 1112.8TP53, GATA4, BIRC5, BRCA2, PCNA
43h2o2448.8TP53, PCNA, BIRC5, BRCA2, GATA4
44testosterone44 61 24 1111.7GATA4, ERVK-6, PCNA, BRCA2, BIRC5
45thymidine44 249.6BRCA2, PCNA, BIRC5, ERVK-6, TP53
46oligonucleotide448.3BIRC5, ERVK-6, PCNA, TP53, BRCA2, GATA4
47estrogen448.3TP53, BRCA2, PCNA, BIRC5, ERVK-6, GATA4
48vegf448.3BIRC5, PDPN, TP53, POU5F1, PCNA
49paraffin447.8ERVK-6, PDPN, PCNA, TP53, BRCA2, BIRC5
50retinoic acid44 248.4GATA6, TP53, SOX2, POU5F1, BRCA2, PCNA

GO Terms for genes affiliated with Ovarian Germ Cell Tumor

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Cellular components related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2SOX2, POU5F1, GATA6
2nucleoplasmGO:0056547.6PCNA, TP53, POU5F1, BRCA2, NANOG, GATA6
3nucleolusGO:0057307.6TP53, SOX2, BRCA2, ERVK-6, PCNA, NANOG
4cytoplasmGO:0057377.5SOX2, POU5F1, BRCA2, PCNA, BIRC5, ERVK-6
5nucleusGO:0056346.8GATA4, TP53, SOX2, GATA6, BIRC5, PCNA

Biological processes related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cardioblast differentiationGO:05189110.2GATA4, GATA6
2intestinal epithelial cell differentiationGO:06057510.2GATA6, GATA4
3response to growth factorGO:07084810.2SOX2, GATA6
4cardiac muscle hypertrophy in response to stressGO:01489810.2GATA6, GATA4
5positive regulation of cardiac muscle cell proliferationGO:06004510.1GATA4, GATA6
6positive regulation of cell cycle arrestGO:07115810.0GATA6, TP53
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP53, BRCA2
8response to X-rayGO:0101659.9BRCA2, TP53
9response to estrogenGO:0436279.9GATA4, GATA6
10cell agingGO:0075699.8TP53, BRCA2
11response to woundingGO:0096119.8POU5F1, SOX2
12response to gamma radiationGO:0103329.8BRCA2, TP53
13intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.8BRCA2, TP53
14tube morphogenesisGO:0352399.7PDPN, GATA6
15in utero embryonic developmentGO:0017019.6GATA4, GATA6, TP53
16endodermal cell fate specificationGO:0017149.6NANOG, POU5F1, SOX2
17somatic stem cell maintenanceGO:0350199.6NANOG, POU5F1, SOX2
18regulation of gene expressionGO:0104689.6SOX2, NANOG, POU5F1
19base-excision repairGO:0062849.6PCNA, TP53
20nucleotide-excision repairGO:0062899.5TP53, BRCA2, PCNA
21lung alveolus developmentGO:0482869.5SOX2, PDPN
22response to retinoic acidGO:0325269.5SOX2, NANOG
23positive regulation of mitotic cell cycleGO:0459319.4BRCA2, NANOG, BIRC5
24cytokinesisGO:0009109.4BIRC5, BRCA2
25positive regulation of transcription, DNA-templatedGO:0458939.3GATA4, BRCA2, SOX2, TP53
26negative regulation of transcription from RNA polymerase II promoterGO:0001229.1NANOG, SOX2, GATA6, TP53
27regulation of transcription, DNA-templatedGO:0063558.7POU5F1, GATA4, NANOG, SOX2, TP53
28positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TP53, SOX2, NANOG, GATA6, GATA4, POU5F1
29cell proliferationGO:0082838.4PCNA, NANOG, PDPN, TP53

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:03519810.0POU5F1, SOX2
2enhancer sequence-specific DNA bindingGO:0011589.6NANOG, GATA4
3chaperone bindingGO:0510879.6BIRC5, TP53
4RNA polymerase II core promoter sequence-specific DNA bindingGO:0009799.4GATA6, TP53
5receptor tyrosine kinase bindingGO:0309719.4TP53, PCNA
6transcription factor bindingGO:0081349.3GATA6, TP53, POU5F1, GATA4
7transcription regulatory region DNA bindingGO:0442129.0GATA4, TP53, SOX2, POU5F1, GATA6
8chromatin bindingGO:0036828.7GATA6, SOX2, TP53, NANOG, GATA4
9zinc ion bindingGO:0082708.6GATA4, ERVK-6, TP53, BIRC5, GATA6
10sequence-specific DNA binding transcription factor activityGO:0037008.4TP53, SOX2, POU5F1, NANOG, GATA6, GATA4
11DNA bindingGO:0036778.1NANOG, SOX2, ERVK-6, TP53, GATA4, POU5F1
12protein bindingGO:0055157.5GATA4, PCNA, GATA6, BIRC5, BRCA2, POU5F1

Products for genes affiliated with Ovarian Germ Cell Tumor

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Sources for Ovarian Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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