MCID: OVR069
MIFTS: 24

Ovarian Germ Cell Tumor malady

Categories: Rare diseases

Aliases & Classifications for Ovarian Germ Cell Tumor

Aliases & Descriptions for Ovarian Germ Cell Tumor:

Name: Ovarian Germ Cell Tumor 50 52 69

Classifications:



Summaries for Ovarian Germ Cell Tumor

MalaCards based summary : Ovarian Germ Cell Tumor is related to pediatric ovarian germ cell tumor and teratoma. An important gene associated with Ovarian Germ Cell Tumor is ALPP (Alkaline Phosphatase, Placental). The drugs Doxorubicin and Vinblastine have been mentioned in the context of this disorder. Affiliated tissues include ovary and lymph node.

Related Diseases for Ovarian Germ Cell Tumor

Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
id Related Disease Score Top Affiliating Genes
1 pediatric ovarian germ cell tumor 12.3
2 teratoma 10.0
3 meige syndrome 10.0
4 growing teratoma syndrome 10.0
5 pseudo-meigs syndrome 10.0
6 mitral valve disease 9.8 ALPP ENO2
7 pituitary hypoplasia 9.8 ALPP ENO2
8 hereditary renal cell carcinoma 9.8 ALPP ENO2
9 pneumonia 9.8 ALPP ENO2
10 testicular germ cell tumor 9.7
11 cortical blindness 9.7
12 gonadal dysgenesis 9.7
13 teratocarcinoma 9.7
14 embryonal carcinoma 9.7
15 peritonitis 9.7
16 hemangioendothelioma 9.7
17 epithelioid hemangioendothelioma 9.7
18 diabetes persistent mullerian ducts 9.7 ALPP ENO2
19 painful legs and moving toes syndrome 9.6 ALPP ENO2 ERVK-6

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to Ovarian Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Germ Cell Tumor

Drugs & Therapeutics for Ovarian Germ Cell Tumor

Drugs for Ovarian Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 335)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Vinblastine Approved Phase 3,Phase 1 865-21-4 13342 241903
3
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
4
Etoposide Approved Phase 3,Phase 1,Phase 2 33419-42-0 36462
5
Cisplatin Approved Phase 3,Phase 1,Phase 2 15663-27-1 84093 441203 2767
6
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
8
Bleomycin Approved Phase 3,Phase 2 11056-06-7 5360373
9
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
10
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
11
Lenograstim Approved Phase 3,Phase 1,Phase 2 135968-09-1
12
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
13
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
Morphine Approved, Investigational Phase 3 57-27-2 5288826
15
Captopril Approved Phase 3 62571-86-2 44093
16
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
17
Ribavirin Approved Phase 3 36791-04-5 37542
18
Fluconazole Approved Phase 3 86386-73-4 3365
19
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
21
Ofloxacin Approved Phase 3 82419-36-1 4583
22
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
23 Sodium thiosulfate Approved Phase 3
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
25
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
26
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
27
Palivizumab Approved, Investigational Phase 3 188039-54-5
28
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
29
Succinylcholine Approved Phase 3 306-40-1 5314
30
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
31
Mycophenolic acid Approved Phase 3 24280-93-1 446541
32
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
33
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
34
Cyproheptadine Approved Phase 3 129-03-3 2913
35
Norgestimate Approved Phase 3 35189-28-7 6540478
36
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
37
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
38
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
40
Dehydroepiandrosterone Approved, Nutraceutical Phase 3 53-43-0 9860744
41
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
42 Alkylating Agents Phase 3,Phase 1,Phase 2
43 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
44 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
45 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
46 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
48 Etoposide phosphate Phase 3,Phase 1,Phase 2
49 Anti-Infective Agents Phase 3,Phase 1,Phase 2
50 Immunosuppressive Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 284)
id Name Status NCT ID Phase
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3
2 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
3 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
5 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3
6 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
7 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
9 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
10 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
12 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
13 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
14 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3
15 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704 Phase 3
16 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
17 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3
18 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3
19 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3
20 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3
21 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Active, not recruiting NCT01376349 Phase 3
22 TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors Enrolling by invitation NCT02429687 Phase 3
23 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3
24 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
25 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3
26 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
27 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2
28 Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Ovarian Cancer Unknown status NCT00003532 Phase 2
29 Squalamine Lactate Plus Carboplatin in Treating Patients With Recurrent or Refractory Stage III or Stage IV Ovarian Cancer Unknown status NCT00021385 Phase 2
30 Paclitaxel-Loaded Polymeric Micelle and Carboplatin as First-Line Therapy in Treating Patients With Advanced Ovarian Cancer Unknown status NCT00886717 Phase 1, Phase 2
31 Whole Body Hyperthermia Combined With Chemotherapy in Treating Patients With Metastatic Breast, Ovarian, Endometrial, or Cervical Cancer Unknown status NCT00003135 Phase 2
32 Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer Unknown status NCT00905658 Phase 2
33 Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation Unknown status NCT00036712 Phase 2
34 Sunitinib® in Patients With Recurrent Ovarian Clear Cell Carcinoma Unknown status NCT01824615 Phase 2
35 Clinical Trial of a Therapeutic Vaccine With NY-ESO-1 in Combination With the Adjuvant Monophosphoryl Lipid A (MPLA) Unknown status NCT01584115 Phase 1, Phase 2
36 Cyclophosphamide, Radiation Therapy, and Poly ICLC in Treating Patients With Unresectable, Recurrent, Primary, or Metastatic Liver Cancer Unknown status NCT00553683 Phase 1, Phase 2
37 Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin Completed NCT00002559 Phase 1, Phase 2
38 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2
39 Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin Completed NCT00006043 Phase 2
40 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2
41 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2
42 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2
43 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2
44 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2
45 Doxorubicin and Carboplatin in Treating Patients With Recurrent Ovarian Cancer Completed NCT00562185 Phase 1, Phase 2
46 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2
47 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2
48 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2
49 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2
50 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2

Search NIH Clinical Center for Ovarian Germ Cell Tumor

Genetic Tests for Ovarian Germ Cell Tumor

Anatomical Context for Ovarian Germ Cell Tumor

MalaCards organs/tissues related to Ovarian Germ Cell Tumor:

39
Ovary, Lymph Node

Publications for Ovarian Germ Cell Tumor

Articles related to Ovarian Germ Cell Tumor:

(show top 50) (show all 73)
id Title Authors Year
1
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. ( 27262834 )
2016
2
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". ( 25511159 )
2015
3
Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors. ( 25842162 )
2015
4
8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors. ( 25743840 )
2015
5
Outcomes of Ovarian Germ Cell Tumors: Ten Years of Experience at the Brazilian National Cancer Institute. ( 25790041 )
2015
6
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. ( 25518772 )
2014
7
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. ( 24681864 )
2014
8
Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors. ( 25341580 )
2014
9
Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. ( 24395845 )
2014
10
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. ( 24836278 )
2014
11
Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. ( 24412326 )
2014
12
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. ( 23575763 )
2013
13
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? ( 24475592 )
2013
14
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. ( 24007946 )
2013
15
Updates in the management of ovarian germ cell tumors. ( 23714505 )
2013
16
Malignant ovarian germ cell tumors: presentation, survival and second cancer in a population based Norwegian cohort (1953-2009). ( 24001518 )
2013
17
Long-term oncological and reproductive outcomes of fertility-sparing cytoreductive surgery in females aged 25 years and younger with malignant ovarian germ cell tumors. ( 24320102 )
2013
18
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. ( 24222875 )
2013
19
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. ( 24376332 )
2013
20
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. ( 23406948 )
2013
21
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. ( 23148694 )
2013
22
Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report. ( 22248255 )
2012
23
Treatment of malignant ovarian germ cell tumors and preservation of fertility. ( 23185794 )
2012
24
Minilaparotomy a good option in specific cases: a case report of bilateral ovarian germ cell tumor. ( 22567526 )
2012
25
Molecular genetic analysis of bilateral ovarian germ cell tumors. ( 23143763 )
2012
26
Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. ( 21256579 )
2011
27
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution. ( 21988930 )
2011
28
Ovarian germ cell tumors in children: a 20-year retrospective study in a single institution. ( 21797119 )
2011
29
Malignant mixed ovarian germ cell tumor with embryonal component. ( 20869284 )
2011
30
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? ( 21822906 )
2011
31
Prognostic impact of laterality in malignant ovarian germ cell tumors. ( 21475076 )
2011
32
Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. ( 21795985 )
2011
33
Management of malignant ovarian germ cell tumors. ( 22018453 )
2011
34
Karyotype result prior to surgery in patients with suspected ovarian germ cell tumors. ( 21594985 )
2011
35
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. ( 20168245 )
2010
36
Ovarian germ cell tumors in children. Management, survival and ovarian prognosis. A report of 75 cases. ( 20638529 )
2010
37
Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy. ( 19878051 )
2010
38
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. ( 19961281 )
2010
39
Bulletin board. Study suggests that following surgery, watchful waiting may be a safe option for girls with early-stage ovarian germ cell tumors. ( 21188885 )
2010
40
Malignant ovarian germ cell tumors: a single-institution experience. ( 19307952 )
2009
41
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. ( 19636015 )
2009
42
A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome. ( 19679044 )
2009
43
Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. ( 19483629 )
2009
44
The influence of conservative surgical practices for malignant ovarian germ cell tumors. ( 18563734 )
2008
45
FDG uptake in parahepatic brown fat mimics peritoneal carcinomatosis in a malignant ovarian germ cell tumor: resolution with temperature control. ( 18936621 )
2008
46
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. ( 18497549 )
2008
47
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. ( 19042263 )
2008
48
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. ( 17602084 )
2007
49
[Survivin expression in ovarian germ cell tumors]. ( 17441339 )
2007
50
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. ( 17413983 )
2007

Variations for Ovarian Germ Cell Tumor

Expression for Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Germ Cell Tumor.

Pathways for Ovarian Germ Cell Tumor

GO Terms for Ovarian Germ Cell Tumor

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 8.62 ALPP ENO2

Sources for Ovarian Germ Cell Tumor

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