MCID: OVR069
MIFTS: 37

Ovarian Germ Cell Tumor malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Ovarian Germ Cell Tumor

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
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Ovarian Germ Cell Tumor, Aliases & Descriptions:

Name: Ovarian Germ Cell Tumor 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Ovarian Germ Cell Tumor

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MalaCards based summary: Ovarian Germ Cell Tumor is related to teratoma and pediatric ovarian germ cell tumor. An important gene associated with Ovarian Germ Cell Tumor is GATA6 (GATA binding protein 6), and among its related pathways are Notch-mediated HES/HEY network and Heart Development. The compounds nimbolide and 7,12-dimethylbenz(a)anthracene have been mentioned in the context of this disorder. Affiliated tissues include lymph node and ovary, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Related Diseases for Ovarian Germ Cell Tumor

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Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma30.2SOX2, POU5F1, NANOG, PDPN, ERVK-6, GATA6
2pediatric ovarian germ cell tumor10.6
3growing teratoma syndrome10.5
4pseudo-meigs syndrome10.5
5atrioventricular septal defect10.4GATA4
6pineoblastoma10.4POU5F1
7tetralogy of fallot10.4GATA6
8endodermal sinus tumor10.3GATA4, GATA6
9germinoma10.3POU5F1, PDPN
10renal cell carcinoma10.3PDPN, TP53
11testicular germ cell tumor10.3
12cortical blindness10.3
13teratocarcinoma10.3
14gonadal dysgenesis10.3
15peritonitis10.3
16hemangioendothelioma10.3
17blindness10.3
18epithelioid hemangioendothelioma10.3
19benign mesothelioma10.2PDPN, TP53
20gallbladder cancer10.2TP53, PDPN
21dysgerminoma10.2POU5F1, BRCA2
22li-fraumeni syndrome10.2TP53, BRCA2
23meningioma, familial10.2PDPN, PCNA
24lynch syndrome10.2TP53, BRCA2
25gestational trophoblastic tumor10.1ERVK-6, PCNA
26malignant pleural mesothelioma10.1PDPN, BIRC5
27adrenocortical carcinoma10.1GATA4, GATA6, TP53
28bladder transitional cell carcinoma10.1BIRC5, TP53
29breast fibroadenoma10.1PCNA, ERVK-6
30papilloma10.1PCNA, TP53
31ductal carcinoma in situ10.1PDPN, BRCA2, TP53
32ameloblastoma10.1PCNA, PDPN
33actinic keratosis10.1TP53, PCNA
34cutaneous t cell lymphoma10.0BIRC5, ERVK-6
35breast cancer10.0PCNA, TP53
36embryonal cancer10.0SOX2, POU5F1, PDPN, GATA4
37benign meningioma10.0PCNA, BIRC5
38cervical cancer, somatic9.9BIRC5, PDPN, TP53
39sarcoma9.9ERVK-6, BRCA2, TP53
40chronic lymphocytic leukemia9.9TP53, BRCA2, BIRC5
41seminoma9.9SOX2, POU5F1, NANOG, PDPN, ERVK-6
42laryngeal carcinoma9.8BIRC5, PCNA, TP53
43laryngeal squamous cell carcinoma9.8BIRC5, PCNA, TP53
44oral cancer9.8BIRC5, PCNA, TP53
45transitional cell carcinoma9.8BIRC5, PCNA, TP53
46endometrial cancer9.8TP53, BRCA2, PCNA
47pancreatic cancer9.8BRCA2, PCNA, BIRC5
48grade iii astrocytoma9.7PCNA, TP53
49ovarian cancer, somatic9.7GATA4, BIRC5, BRCA2, TP53
50bladder cancer, somatic9.7TP53, PCNA, BIRC5

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to ovarian germ cell tumor

Symptoms for Ovarian Germ Cell Tumor

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Drugs & Therapeutics for Ovarian Germ Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Ovarian Germ Cell Tumor

Search NIH Clinical Center for Ovarian Germ Cell Tumor

Genetic Tests for Ovarian Germ Cell Tumor

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Anatomical Context for Ovarian Germ Cell Tumor

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MalaCards organs/tissues related to Ovarian Germ Cell Tumor:

31
Lymph node, Ovary

Animal Models for Ovarian Germ Cell Tumor or affiliated genes

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Publications for Ovarian Germ Cell Tumor

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Articles related to Ovarian Germ Cell Tumor:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". (25511159)
2015
2
8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors. (25743840)
2015
3
Outcomes of Ovarian Germ Cell Tumors: Ten Years of Experience at the Brazilian National Cancer Institute. (25790041)
2015
4
Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. (24395845)
2014
5
Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. (24412326)
2014
6
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. (24681864)
2014
7
Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors. (25341580)
2014
8
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. (23575763)
2013
9
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. (24222875)
2013
10
Updates in the management of ovarian germ cell tumors. (23714505)
2013
11
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? (24475592)
2013
12
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. (23406948)
2013
13
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. (23148694)
2013
14
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
15
Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report. (22248255)
2012
16
Molecular genetic analysis of bilateral ovarian germ cell tumors. (23143763)
2012
17
Karyotype result prior to surgery in patients with suspected ovarian germ cell tumors. (21594985)
2011
18
Ovarian germ cell tumors in children: a 20-year retrospective study in a single institution. (21797119)
2011
19
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution. (21988930)
2011
20
Prognostic impact of laterality in malignant ovarian germ cell tumors. (21475076)
2011
21
Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. (21795985)
2011
22
Bulletin board. Study suggests that following surgery, watchful waiting may be a safe option for girls with early-stage ovarian germ cell tumors. (21188885)
2010
23
Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy. (19878051)
2010
24
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. (19961281)
2010
25
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. (20168245)
2010
26
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. (19636015)
2009
27
Malignant ovarian germ cell tumors: a single-institution experience. (19307952)
2009
28
A mini-review of familial ovarian germ cell tumors: an additional manifestation of the familial testicular germ cell tumor syndrome. (19679044)
2009
29
Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors. (19483629)
2009
30
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. (19042263)
2008
31
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. (18497549)
2008
32
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. (17413983)
2007
33
Survivin expression in ovarian germ cell tumors]. (17441339)
2007
34
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. (17048439)
2006
35
Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: correlation with the cell proliferation activity and clinicopathologic features. (17016588)
2006
36
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. (16578998)
2006
37
Growing teratoma syndrome after ovarian germ cell tumors. (16946208)
2006
38
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. (16623016)
2005
39
Trisomy 14pter --> q21: a case with associated ovarian germ cell tumor and review of the literature. (15211663)
2004
40
Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. (10533299)
1999
41
A case of pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9841228)
1998
42
Cytogenetics of a malignant ovarian germ-cell tumor. (9650555)
1998
43
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. (9299274)
1997
44
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). (8908168)
1996
45
Overexpression or mutation of the p53 tumor suppressor gene does not occur in malignant ovarian germ cell tumors. (8625105)
1995
46
Radiological case of the month. Malignant ovarian germ cell tumor. (8395763)
1993
47
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. (2253191)
1990
48
A canine ovarian germ cell tumor with extraembryonic differentiation. (3029938)
1987
49
Mixed ovarian germ cell tumor in 46,X, +mar Turner's syndrome: a case report. (6525086)
1984
50
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. (6203815)
1984

Variations for Ovarian Germ Cell Tumor

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Expression for genes affiliated with Ovarian Germ Cell Tumor

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Search GEO for disease gene expression data for Ovarian Germ Cell Tumor.

Pathways for genes affiliated with Ovarian Germ Cell Tumor

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Pathways related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GATA6, GATA4
29.9GATA4, GATA6
39.7BRCA2, BIRC5
49.6BIRC5, TP53
59.5TP53, PCNA
69.5PCNA, TP53
79.5PCNA, TP53
89.4TP53, GATA6, GATA4
99.2BIRC5, BRCA2, TP53
109.2SOX2, POU5F1, NANOG
119.2NANOG, POU5F1, SOX2
129.2NANOG, POU5F1, SOX2
13
Show member pathways
9.1PCNA, BRCA2, TP53
14
Show member pathways
9.1PCNA, BRCA2, TP53
159.1TP53, BRCA2, PCNA
169.1PCNA, BRCA2, TP53
17
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1BIRC5, PCNA, TP53
18
Show member pathways
Signal transduction PTEN pathway58
9.1BIRC5, PCNA, TP53
198.9SOX2, POU5F1, NANOG, GATA6
20
Show member pathways
8.9GATA4, BIRC5, BRCA2, TP53
218.9SOX2, POU5F1, NANOG, GATA4
22
Show member pathways
8.9SOX2, POU5F1, NANOG, GATA4
23
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.8NANOG, POU5F1, SOX2, TP53
248.6GATA4, GATA6, NANOG, POU5F1, SOX2

Compounds for genes affiliated with Ovarian Germ Cell Tumor

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Compounds related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1nimbolide439.9PCNA, BIRC5
27,12-dimethylbenz(a)anthracene439.9BIRC5, BRCA2
3norcantharidin439.8BIRC5, PCNA
4acridine439.8PCNA, BIRC5
53,3-diindolylmethane439.8BIRC5, TP53
6daidzein439.7BRCA2, BIRC5
78-oxoguanine439.7BRCA2, PCNA
8rofecoxib43 49 28 1212.7PCNA, BIRC5
9indole-3-carbinol439.7TP53, BRCA2, BIRC5
10vincristine43 49 1211.6BIRC5, BRCA2, TP53
118-oxo-dg439.6TP53, PCNA
12adriamycin439.6TP53, BRCA2, BIRC5
13o6-methylguanine439.6PCNA, BRCA2, TP53
14methylmethanesulfonate439.5PCNA, BRCA2, TP53
15docetaxel43 49 59 1212.5TP53, BRCA2, BIRC5
16dutp439.5TP53, PCNA, BIRC5
17sulindac43 1210.5TP53, PCNA, BIRC5
18roscovitine439.5TP53, PCNA, BIRC5
19hydroxyurea43 49 1211.5PCNA, BRCA2, TP53
20gemcitabine43 49 1211.4TP53, PCNA, BIRC5
21olomoucine43 1210.4TP53, PCNA
22mg 13243 5910.4BIRC5, PCNA, TP53
23curcumin439.3ERVK-6, BIRC5, TP53
245-aza-2deoxycytidine439.3GATA4, GATA6, PCNA, TP53
25arsenite43 2410.3TP53, PCNA, BIRC5
26butyrate439.2GATA6, BIRC5, PCNA, TP53
27vitamin a43 24 1211.2BIRC5, GATA6, GATA4
28adpribose439.2TP53, BRCA2, PCNA, BIRC5
29mitomycin c439.2BIRC5, PCNA, BRCA2, TP53
30resveratrol43 59 24 1212.2TP53, BRCA2, PCNA, BIRC5
31camptothecin43 59 1211.1BIRC5, PCNA, BRCA2, TP53
32etoposide43 49 59 1212.1BIRC5, PCNA, BRCA2, TP53
33guanine43 24 1211.1ERVK-6, BIRC5, TP53
34tamoxifen43 49 28 1212.1TP53, BRCA2, PCNA, BIRC5
35paclitaxel43 49 1211.1BIRC5, PCNA, BRCA2, TP53
36gold439.1BRCA2, PDPN, ERVK-6
37zinc43 2410.0SOX2, BRCA2, ERVK-6, GATA6, GATA4
38cisplatin43 49 59 1212.0BIRC5, PCNA, BRCA2, TP53
39thymidylate439.0TP53, PCNA, BIRC5, ERVK-6
40egcg439.0TP53, PCNA, BIRC5, ERVK-6
41steroid438.9BRCA2, BIRC5, ERVK-6, GATA6, GATA4
42progesterone43 28 59 24 1212.8TP53, BRCA2, PCNA, BIRC5, GATA4
43h2o2438.8TP53, BRCA2, PCNA, BIRC5, GATA4
44testosterone43 59 24 1211.7BRCA2, PCNA, BIRC5, ERVK-6, GATA4
45thymidine43 249.6TP53, BRCA2, PCNA, BIRC5, ERVK-6
46oligonucleotide438.3TP53, BRCA2, PCNA, BIRC5, ERVK-6, GATA4
47estrogen438.3TP53, BRCA2, PCNA, BIRC5, ERVK-6, GATA4
48vegf438.3TP53, POU5F1, PCNA, PDPN, BIRC5
49paraffin437.8TP53, BRCA2, PCNA, PDPN, BIRC5, ERVK-6
50retinoic acid43 248.4GATA4, TP53, SOX2, POU5F1, BRCA2, PCNA

GO Terms for genes affiliated with Ovarian Germ Cell Tumor

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Cellular components related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056679.2GATA6, POU5F1, SOX2
2nucleoplasmGO:00056547.6GATA4, TP53, POU5F1, BRCA2, NANOG, PCNA
3nucleolusGO:00057307.6TP53, SOX2, BRCA2, NANOG, PCNA, ERVK-6
4cytoplasmGO:00057377.5SOX2, POU5F1, BRCA2, PCNA, BIRC5, ERVK-6
5nucleusGO:00056346.8TP53, SOX2, POU5F1, BRCA2, NANOG, PCNA

Biological processes related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1intestinal epithelial cell differentiationGO:006057510.2GATA6, GATA4
2positive regulation of cardioblast differentiationGO:005189110.2GATA6, GATA4
3response to growth factorGO:007084810.2GATA6, SOX2
4cardiac muscle hypertrophy in response to stressGO:001489810.2GATA4, GATA6
5positive regulation of cardiac muscle cell proliferationGO:006004510.1GATA4, GATA6
6positive regulation of cell cycle arrestGO:007115810.0GATA6, TP53
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.9BRCA2, TP53
8response to X-rayGO:00101659.9BRCA2, TP53
9response to estrogenGO:00436279.9GATA4, GATA6
10cell agingGO:00075699.8BRCA2, TP53
11response to woundingGO:00096119.8POU5F1, SOX2
12response to gamma radiationGO:00103329.8BRCA2, TP53
13intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.8TP53, BRCA2
14tube morphogenesisGO:00352399.7GATA6, PDPN
15in utero embryonic developmentGO:00017019.6TP53, GATA6, GATA4
16endodermal cell fate specificationGO:00017149.6NANOG, POU5F1, SOX2
17somatic stem cell maintenanceGO:00350199.6NANOG, POU5F1, SOX2
18regulation of gene expressionGO:00104689.6SOX2, POU5F1, NANOG
19base-excision repairGO:00062849.6TP53, PCNA
20nucleotide-excision repairGO:00062899.5PCNA, BRCA2, TP53
21lung alveolus developmentGO:00482869.5PDPN, SOX2
22response to retinoic acidGO:00325269.5NANOG, SOX2
23positive regulation of mitotic cell cycleGO:00459319.4BRCA2, NANOG, BIRC5
24cytokinesisGO:00009109.4BIRC5, BRCA2
25positive regulation of transcription, DNA-templatedGO:00458939.3TP53, SOX2, BRCA2, GATA4
26negative regulation of transcription from RNA polymerase II promoterGO:00001229.1TP53, SOX2, NANOG, GATA6
27regulation of transcription, DNA-templatedGO:00063558.7TP53, SOX2, POU5F1, NANOG, GATA4
28positive regulation of transcription from RNA polymerase II promoterGO:00459448.5TP53, SOX2, POU5F1, NANOG, GATA6, GATA4
29cell proliferationGO:00082838.4TP53, NANOG, PCNA, PDPN

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:003519810.0POU5F1, SOX2
2enhancer sequence-specific DNA bindingGO:00011589.6GATA4, NANOG
3chaperone bindingGO:00510879.6BIRC5, TP53
4RNA polymerase II core promoter sequence-specific DNA bindingGO:00009799.4GATA6, TP53
5receptor tyrosine kinase bindingGO:00309719.4TP53, PCNA
6transcription factor bindingGO:00081349.3TP53, POU5F1, GATA6, GATA4
7transcription regulatory region DNA bindingGO:00442129.0GATA4, GATA6, POU5F1, SOX2, TP53
8chromatin bindingGO:00036828.7TP53, SOX2, NANOG, GATA6, GATA4
9zinc ion bindingGO:00082708.6TP53, BIRC5, ERVK-6, GATA6, GATA4
10sequence-specific DNA binding transcription factor activityGO:00037008.4TP53, SOX2, POU5F1, NANOG, GATA6, GATA4
11DNA bindingGO:00036778.1TP53, SOX2, POU5F1, NANOG, ERVK-6, GATA4
12protein bindingGO:00055157.5TP53, SOX2, POU5F1, BRCA2, PCNA, BIRC5

Products for genes affiliated with Ovarian Germ Cell Tumor

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Sources for Ovarian Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
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46OMIM via Orphanet
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