MCID: OVR069
MIFTS: 32

Ovarian Germ Cell Tumor malady

Cancer diseases category

Summaries for Ovarian Germ Cell Tumor

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MalaCards: Ovarian Germ Cell Tumor is related to ovarian cancer and pediatric ovarian germ cell tumor. An important gene associated with Ovarian Germ Cell Tumor is GATA6 (GATA binding protein 6), and among its related pathways are FOXM1 transcription factor network and Aurora A signaling. The compounds estrogen and etoposide have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and integument.

Aliases & Classifications for Ovarian Germ Cell Tumor

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ovarian germ cell tumor 42 44 60


Related Diseases for Ovarian Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Ovarian Germ Cell Malignant Tumor family:

ovarian germ cell tumor

Diseases related to Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer30.5TP53, BIRC5, PCNA, BRCA2
2pediatric ovarian germ cell tumor10.5
3teratocarcinoma10.2
4cortical blindness10.2
5ovarian disease10.2
6peritonitis10.2
7ovarian germ cell malignant tumor10.2
8pancreatitis10.0BRCA2
9cervical intraepithelial neoplasia10.0BIRC5
10breast-ovarian cancer, familial, 210.0BRCA2
11esophageal cancer10.0TP53
12leukoplakia10.0PCNA
13neuroblastoma10.0TP53
14myeloid leukemia10.0BIRC5
15brain cancer10.0TP53
16peritoneal carcinoma10.0BRCA2
17bilateral breast cancer10.0BRCA2
18atrioventricular septal defect10.0GATA4
19pineoblastoma10.0POU5F1
20tetralogy of fallot10.0GATA6, GATA4
21endodermal sinus tumor10.0GATA4, GATA6
22hepatoblastoma10.0BIRC5
23benign meningioma10.0BIRC5, PCNA
24osteosarcoma10.0BIRC5, TP53
25medulloblastoma10.0BRCA2, TP53
26malignant mesothelioma10.0PDPN
27psoriasis10.0POU5F1
28male breast cancer10.0PCNA, BRCA2
29sarcoma10.0BRCA2, TP53
30gonadoblastoma10.0POU5F1
31astrocytoma10.0TP53, PCNA
32papilloma10.0PCNA, TP53
33bladder transitional cell carcinoma10.0TP53, BIRC5
34familial adenomatous polyposis10.0TP53, BIRC5
35li-fraumeni syndrome10.0BRCA2, TP53
36oligodendroglioma10.0TP53, PCNA
37breast cancer, invasive ductal10.0PCNA, TP53
38ataxia telangiectasia10.0BRCA2, TP53
39adrenocortical carcinoma10.0TP53, GATA6, GATA4
40oral cancer10.0BIRC5, TP53, PCNA
41wilms tumor10.0PDPN, BRCA2
42pancreatic cancer10.0BIRC5, BRCA2, PCNA
43bladder carcinoma in situ10.0PCNA, BIRC5, TP53
44laryngeal squamous cell carcinoma10.0TP53, PCNA, BIRC5
45b-cell chronic lymphocytic leukemia10.0TP53, BIRC5, BRCA2
46transitional cell carcinoma10.0PCNA, BIRC5, TP53
47meningioma10.0PDPN, PCNA
48non-small cell lung carcinoma10.0TP53, PCNA, BIRC5
49cervical cancer10.0PCNA, BIRC5, TP53
50endometrial carcinoma10.0BRCA2, TP53, PCNA

Graphical network of the top 20 diseases related to Ovarian Germ Cell Tumor:



Diseases related to ovarian germ cell tumor

Clinical Features for Ovarian Germ Cell Tumor

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Drugs & Therapeutics for Ovarian Germ Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ovarian Germ Cell Tumor

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Anatomical Context for Ovarian Germ Cell Tumor

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Animal Models for Ovarian Germ Cell Tumor or affiliated genes

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36MGI
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Publications for Ovarian Germ Cell Tumor

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Genetic Variations for Ovarian Germ Cell Tumor

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Expression for genes affiliated with Ovarian Germ Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Germ Cell Tumor.

Pathways for genes affiliated with Ovarian Germ Cell Tumor

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8BIRC5, BRCA2
29.7BIRC5, TP53
3
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9.5PCNA, BRCA2
49.4TP53, GATA6, GATA4
59.4PCNA, TP53
6
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9.4TP53, GATA4, BRCA2
7
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9.1TP53, BIRC5, PCNA
8
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9.1PCNA, BIRC5, TP53
9
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.1TP53, PCNA, BRCA2
109.1BRCA2, PCNA, TP53
118.7NANOG, POU5F1, SOX2
128.7NANOG, POU5F1, SOX2
138.7SOX2, POU5F1, NANOG
148.4SOX2, GATA6, POU5F1, NANOG
15
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8.4SOX2, GATA4, POU5F1, NANOG
168.4NANOG, POU5F1, GATA4, SOX2
17
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8.3TP53, NANOG, POU5F1, SOX2
188.3SOX2, POU5F1, NANOG, TP53
198.1NANOG, POU5F1, GATA6, GATA4, SOX2

Compounds for genes affiliated with Ovarian Germ Cell Tumor

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5GATA4
2etoposide44 49 59 1113.5BRCA2
3adriamycin4410.5BIRC5
4vincristine44 49 1112.5BRCA2
57,12-dimethylbenz(a)anthracene4410.1BRCA2, BIRC5
63,3-diindolylmethane4410.0TP53, BIRC5
7daidzein4410.0BIRC5, BRCA2
8nimbolide449.9BIRC5, PCNA
9norcantharidin449.9BIRC5, PCNA
10acridine449.8PCNA, BIRC5
11rofecoxib44 49 28 1112.8BIRC5, PCNA
12indole-3-carbinol449.8BIRC5, TP53, BRCA2
13paclitaxel44 49 1111.7BRCA2, BIRC5, TP53
148-oxoguanine449.7PCNA, BRCA2
15olomoucine44 1110.7PCNA, TP53
16hoechst 33342449.7BIRC5, PCNA
17docetaxel44 49 59 1112.7BRCA2, BIRC5, TP53
188-oxo-dg449.7PCNA, TP53
19vitamin a44 11 2411.6GATA4, GATA6, BIRC5
20taxane449.6BIRC5, TP53
21sulindac sulfide449.6PCNA, TP53
22sulindac44 1110.5BIRC5, PCNA, TP53
23dutp449.5PCNA, BIRC5, TP53
24temozolomide44 1110.5PCNA, TP53
25roscovitine449.5TP53, BIRC5, PCNA
26o6-methylguanine449.5PCNA, TP53, BRCA2
27methylmethanesulfonate449.5TP53, BRCA2, PCNA
28gemcitabine44 49 1111.5PCNA, TP53, BIRC5
29thymidylate449.5TP53, BIRC5, PCNA
30hydroxyurea44 49 1111.5PCNA, TP53, BRCA2
31mg 13244 5910.4PCNA, BIRC5, TP53
32arsenite44 2410.4BIRC5, TP53, PCNA
335-aza-2deoxycytidine449.3TP53, GATA6, GATA4, PCNA
34lycopene44 2410.2BRCA2, PCNA
35adpribose449.2PCNA, BIRC5, TP53, BRCA2
36mitomycin c449.2TP53, BIRC5, PCNA, BRCA2
37resveratrol44 59 11 2412.2PCNA, BIRC5, TP53, BRCA2
38camptothecin44 59 1111.2BRCA2, PCNA, BIRC5, TP53
39methotrexate44 49 1111.1BIRC5, PCNA, BRCA2
40tamoxifen44 49 28 1112.1TP53, BRCA2, PCNA, BIRC5
415fluorouracil449.1PCNA, TP53, BIRC5
42cisplatin44 49 59 1112.1TP53, PCNA, BIRC5, BRCA2
43thymidine44 2410.1BIRC5, PCNA, BRCA2, TP53
44testosterone44 59 11 2412.0BIRC5, BRCA2, GATA4, PCNA
45progesterone44 59 28 11 2412.8PCNA, BRCA2, GATA4, BIRC5, TP53
46h2o2448.8BIRC5, TP53, PCNA, GATA4, BRCA2
47oligonucleotide448.8BIRC5, PCNA, GATA4, BRCA2, TP53
48paraffin448.6BRCA2, PCNA, BIRC5, PDPN, TP53
49vegf448.4POU5F1, PDPN, PCNA, BIRC5, TP53
50retinoic acid44 248.6TP53, BRCA2, SOX2, GATA4, GATA6, POU5F1

GO Terms for genes affiliated with Ovarian Germ Cell Tumor

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16Gene Ontology
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Cellular components related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.2POU5F1, GATA6, SOX2
2nucleoplasmGO:0056547.0TP53, BRCA2, GATA4, GATA6, POU5F1, PCNA
3nucleusGO:0056346.0BRCA2, SOX2, GATA4, GATA6, POU5F1, PCNA

Biological processes related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cardioblast differentiationGO:05189110.2GATA6, GATA4
2intestinal epithelial cell differentiationGO:06057510.2GATA6, GATA4
3cardiac muscle hypertrophy in response to stressGO:01489810.1GATA4, GATA6
4positive regulation of cardiac muscle cell proliferationGO:06004510.1GATA6, GATA4
5response to growth factor stimulusGO:07084810.0SOX2, GATA6
6positive regulation of cell cycle arrestGO:07115810.0TP53, GATA6
7tube morphogenesisGO:03523910.0PDPN, GATA6
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.0TP53, BRCA2
9response to X-rayGO:0101659.9BRCA2, TP53
10intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.8TP53, BRCA2
11cell agingGO:0075699.8TP53, BRCA2
12response to gamma radiationGO:0103329.7BRCA2, TP53
13base-excision repairGO:0062849.4TP53, PCNA
14nucleotide-excision repairGO:0062899.4BRCA2, PCNA, TP53
15in utero embryonic developmentGO:0017019.3TP53, GATA6, GATA4
16positive regulation of mitotic cell cycleGO:0459319.3BRCA2, NANOG, BIRC5
17lung alveolus developmentGO:0482869.2PDPN, SOX2
18positive regulation of transcription, DNA-dependentGO:0458939.2BRCA2, SOX2, GATA4, TP53
19endodermal cell fate specificationGO:0017149.0NANOG, POU5F1, SOX2
20somatic stem cell maintenanceGO:0350199.0NANOG, POU5F1, SOX2
21regulation of gene expressionGO:0104689.0NANOG, POU5F1, SOX2
22negative regulation of transcription from RNA polymerase II promoterGO:0001228.7TP53, NANOG, GATA6, SOX2
23cell proliferationGO:0082838.4TP53, NANOG, PCNA, PDPN
24regulation of transcription, DNA-dependentGO:0063558.1SOX2, GATA4, POU5F1, NANOG, TP53
25positive regulation of transcription from RNA polymerase II promoterGO:0459448.0SOX2, GATA4, GATA6, POU5F1, NANOG, TP53

Molecular functions related to Ovarian Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1miRNA bindingGO:0351989.5POU5F1, SOX2
2enhancer sequence-specific DNA bindingGO:0011589.2GATA4, NANOG
3receptor tyrosine kinase bindingGO:0309719.1TP53, PCNA
4transcription factor bindingGO:0081349.0GATA4, GATA6, POU5F1, TP53
5transcription regulatory region DNA bindingGO:0442128.6TP53, POU5F1, GATA6, GATA4, SOX2
6chromatin bindingGO:0036828.3SOX2, GATA4, GATA6, NANOG, TP53
7sequence-specific DNA binding transcription factor activityGO:0037007.8SOX2, GATA4, GATA6, POU5F1, NANOG, TP53
8protein bindingGO:0055157.1SOX2, GATA4, GATA6, POU5F1, PCNA, BIRC5

Products for genes affiliated with Ovarian Germ Cell Tumor

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Sources for Ovarian Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet