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OHSS
MCID: OVR029

Ovarian Hyperstimulation Syndrome malady
2 drugs, 55 genes, 6 tissues, 902 related diseases, 24 phenotypes, 182 articles, clinical trials, genetic tests.

Summaries for Ovarian Hyperstimulation Syndrome

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44Wikipedia, 33OMIM, 22MalaCards
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Wikipedia: Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication. Most...44 more...

MalaCards: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to thrombosis and thrombophilia. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and NFAT Signaling and Lymphocyte Interactions. The drugs ganirelix acetate and ganirelix and the compounds cyclophosphamide and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and t cells, and related mouse phenotypes are hematopoietic system and respiratory system.

OMIM: 608115

Aliases & Descriptions for Ovarian Hyperstimulation Syndrome

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6Disease Ontology, 7diseasecard, 16GeneTests, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 24MeSH, 40SNOMED-CT
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Aliases & Descriptions:

ovarian hyperstimulation syndrome 6 7 16 8 33 32 43
secondary meig's syndrome 6
ohss 16

External Ids:

SNOMED-CT40 129635004

Related Diseases for Ovarian Hyperstimulation Syndrome

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13GeneCards, 14GeneDecks
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Diseases related to ovarian hyperstimulation syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 899)
idRelated DiseaseScoreTop Affiliating Genes
1thrombosis32.5MTHFR, F5, F2
2thrombophilia31.8SERPINC1, MTHFR, APOH, F5, F3, F2
3polycystic ovary syndrome30.2LHCGR, LEP, CGA, CGB5, FSHR, INS
4venous thrombosis29.4SERPINC1, MTHFR, APOH, F5, F3, F2
5hypogonadism26.3SERPINC1, BRD2, LHCGR, LEP, CGA, CGB5
6aldosteronism24.3REN, VEGFA, LHCGR, CGA, INS, INSR
7infertility21.9BRD2, VEGFA, BMP15, LHCGR, LEP, MTHFR
8insulin resistance21.3REN, VEGFA, KDR, BCHE, LEP, MTHFR
9blindness20.6REN, SERPINC1, VEGFA, KDR, LEP, MTHFR
10adenoma19.7REN, BRD2, VEGFA, KDR, LHCGR, LEP
11peritonitis19.0REN, SERPINC1, VEGFA, KDR, BCHE, LEP
12primary ciliary dyskinesia13.9BMP15, CGA, CYP19A1
13leydig cell adenoma13.8LHCGR, CGA, GNRH1
14gonadotropin deficiency13.8CGA, FSHR, GNRH1, CYP19A1
15precocious puberty, male13.8LHCGR, FSHR, CYP19A1
16ovarian dysgenesis13.8BMP15, LHCGR, FSHR
17micropenis13.8LHCGR, CGA, CGB5, GNRH1
18ovarian cyst13.7VEGFA, CGA, CGB5, GNRH1, CYP19A1
19placental infarction13.7SERPINC1, APOH, F5
20hypogonadism, hypergonadotropic13.7FSHR, CYP19A1, SHBG
21hydrocele13.7VEGFA, CGA, CGB5
2221-hydroxylase deficiency13.7REN, GNRH1, CYP11A1, CYP19A1
23sagittal sinus thrombosis13.7SERPINC1, F5, F3
24mccune albright syndrome13.7BRD2, AMH, GNRH1, CYP19A1
25short limb dwarf edema iris coloboma13.7ALB, CYP19A1, NPPA
26testotoxicosis13.7LHCGR, CYP19A1
27male pseudohermaphroditism due to defective lh13.7LHCGR, CGB5, AMH
28testicular disease13.7BRD2, GNRH1, SHBG
29growth hormone secreting pituitary adenoma13.6VEGFA, CGA, F2RL1, CREB1
30mondor disease13.6APOH, F5
31ectopic pregnancy13.6CGA, CGB5, SP1
32pseudohermaphroditism13.6BRD2, LHCGR, CGB5, FSHR, AMH, CYP19A1
33coronary thrombosis13.6SERPINC1, F5, F3
34premature ovarian failure13.6BMP15, FSHR, GNRH1, CYP11A1, SHBG
35adrenal adenoma13.6REN, CYP11A1, CYP19A1, CREB1
36intracranial thrombosis13.5SERPINC1, F5, F2
37factor xii deficiency13.5F5, F3, F2
38factor x deficiency13.5F5, F3, F2
39aorta atresia13.5CGA, GNRH1, CYP19A1
40dysfibrinogenemia13.5SERPINC1, F5, F2, ALB
41factor v deficiency13.5F5, F3, F2
42hypothyroidism13.5CGA, FSHR, IL1A, SHBG
43schnitzler syndrome13.5IL18, IL1A, IL1R1
44neonatal stroke13.5MTHFR, F5, ALB
45conn's syndrome13.5REN, INSR, CYP11A1, NPPA
46factor viii deficiency13.5F5, F3, F2
47prothrombin deficiency13.5SERPINC1, APOH, F5, F2
48stroke, ischemic13.5F5, F2
49y chromosome infertility13.5CGA, CGB5, CFTR, FSHB, FSHR, AMH
50factor xi deficiency13.5F5, F3, F2

Graphical network of the top 20 diseases related to ovarian hyperstimulation syndrome:



Graphical network of diseases related to ovarian hyperstimulation syndrome

Clinical Features for Ovarian Hyperstimulation Syndrome

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33OMIM
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Clinical features from OMIM: 608115

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for ovarian hyperstimulation syndrome

Drug clinical trials:

Search ClinicalTrials for ovarian hyperstimulation syndrome

Search NIH Clinical Center for ovarian hyperstimulation syndrome

Search CenterWatch for ovarian hyperstimulation syndrome

Inferred drug relations via UMLS/NDF-RT:

43 28 ganirelix, ganirelix acetate

Genetic Tests for Ovarian Hyperstimulation Syndrome

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16GeneTests
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Genetic tests related to ovarian hyperstimulation syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome
clinical/research 		FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

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22MalaCards
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MalaCards organs/tissues related to ovarian hyperstimulation syndrome:

22
Liver, Ovary, T cells, Endothelial, Fetal liver, Pituitary

Phenotypes for genes affiliated with Ovarian Hyperstimulation Syndrome

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25MGI
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MGI Mouse Phenotypes related to ovarian hyperstimulation syndrome:

25 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.6CDH5, FSHR
2respiratory system phenotypeMP:000538810.0CFTR, INSR
3endocrine/exocrine gland phenotypeMP:00053799.9BRD2, BMP15, LHCGR, FSHB, FSHR, IL2
4renal/urinary system phenotypeMP:00053678.8NPPA, EGFR, RHCG, GNRH1, F2RL1, INSR
5embryogenesis phenotypeMP:00053808.8EGFR, CREB1, SP1, TBX4, F2, CDH5
6integument phenotypeMP:00107718.5EGFR, SP1, CYP19A1, GNRH1, F2RL1, F2
7no phenotypic analysisMP:00030128.1EGFR, RHCG, TBX4, F2RL1, AMH, INS
8reproductive system phenotypeMP:00053897.8AMH, GNRH1, CYP11A1, RHCG, IL6, IL10
9liver/biliary system phenotypeMP:00053707.5IL2, IL6, CYP19A1, EGFR, IL1R1, INS
10digestive/alimentary phenotypeMP:00053817.4EGFR, EDN1, GNRH1, F2, IL18, INSR
11skeleton phenotypeMP:00053907.2GNRH1, TBX4, CYP19A1, SP1, EGFR, F2RL1
12immune system phenotypeMP:00053877.2EGFR, CYP19A1, LHCGR, CFTR, FSHR, CD79A
13adipose tissue phenotypeMP:00053756.9IL6, IL6R, CYP19A1, EGFR, ACE, IL1R1
14nervous system phenotypeMP:00036316.9F2, F2RL1, GNRH1, TBX4, CYP19A1, CREB1
15normal phenotypeMP:00028736.7F2, ALB, GNRH1, TBX4, CYP11A1, CYP19A1
16muscle phenotypeMP:00053696.3F3, CYP11A1, CYP19A1, CREB1, EDN1, EGFR
17tumorigenesisMP:00020066.2F3, F2RL1, GNRH1, EGFR, ACE, AMH
18vision/eye phenotypeMP:00053915.6IL18, IL1R1, IL6, F3, SP1, EGFR
19growth/size phenotypeMP:00053785.4IL6, F3, GNRH1, CYP11A1, CYP19A1, SP1
20behavior/neurological phenotypeMP:00053865.1IL2, IL6, IL6R, F5, F3, F2RL1
21mortality/agingMP:00107684.2APOH, F5, F3, F2, F2RL1, TBX4
22homeostasis/metabolism phenotypeMP:00053763.9REN, INS, INSR, IL18, IL1A, IL6R
23cellular phenotypeMP:00053843.9F2RL1, F2, F3, IL6, IL2, GNRH1
24cardiovascular system phenotypeMP:00053853.5IL1R1, IL2, IL6, F5, F3, F2

Publications for genes affiliated with Ovarian Hyperstimulation Syndrome

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35PubMed
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Articles related to ovarian hyperstimulation syndrome:

(show top 50)    (show all 182)
idTitleAuthorsYearAffiliating Genes
1Prevention of ovarian hyperstimulation syndrome in a rat model: efficacy comparison between cabergoline and meloxicam. (20423279)Saylan A.... Yilmazer M.2010VEGFA
2Ovarian hyperstimulation syndrome (OHSS) due to mutat ions in the follicle-stimulating hormone receptor. (20362966)Rodien P.... Vasseur C.2010FSHR
3Miscarriage and clinical correlates of leukocyte coun t in patients with ovarian hyperstimulation syndrome. (19835500)Qublan H.S.... Malkawi H.Y.2009CGB5
4Spontaneous ovarian hyperstimulation syndrome and pit uitary adenoma: incidental pregnancy triggers a catastrophic event. (19356755)Baba T.... Saito T.2009FSHR
5Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: a case series . (19608177)Rollene N.L.... Coddington C.C.2009GNRH1
6High doses of GnRH antagonists are efficient in the m anagement of severe ovarian hyperstimulation syndrome. (19688946)Bonilla-Musoles F.M.... Osborne N.2009GNRH1
7Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. (17721928)De Leener A.... Costagliola S.2008FSHR, CGA
8The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. (17462639)Engmann L.... Benadiva C.2008GNRH1, CGB5
9Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome. (17356124)Kosaka K.... Fujii S.2007VEGFA
10Management of severe early ovarian hyperstimulation syndrome by re-initiation of GnRH antagonist. (17908403)Lainas T.G.... Kolibianakis E.M.2007GNRH1
11Vascular endothelial cadherin regulates vascular permeability: Implications for ovarian hyperstimulation syndrome. (17032719)Villasante A.... Garcia-Velasco J.A.2007CDH5, CGB5
12No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome. (16391898)Ferk P.... Teran N.2006CYP11A1
13Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). (16788381)Moron F.J.... Ruiz A.2006BMP15
14Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. (16278261)De Leener A.... Costagliola S.2006FSHR, CGA
15Early and late ovarian hyperstimulation syndrome: early pregnancy outcome and profile. (15576388)Papanikolaou E.G.... Devroey P.2005CGA
16Absence of follicle-stimulating hormone receptor activating mutations in women with iatrogenic ovarian hyperstimulation syndrome. (15950638)D'Alva C.B.... Mendonca B.B.2005FSHR
17The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome. (14998945)Tozer A.J.... Grudzinskas J.G.2004VEGFA, CGA
18Low-molecular-weight dextran infusion is more effective for the treatment of hemoconcentration due to severe ovarian hyperstimulation syndrome than human albumin infusion. (15533378)Endo T.... Azumaguchi A.2004ALB
19Intensive care and treatment of severe ovarian hyperstimulation syndrome (15485803)Ma M.Y.... Fang B.2004ALB
20Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment. (15374699)Ayustawati .... Suzuki M.2004LEP
21Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism. (15579795)Daelemans C.... Delbaere A.2004FSHR
22Dual renin-angiotensin blockade therapy in patients at high risk of early ovarian hyperstimulation syndrome receiving IVF and elective embryo cryopreservation: a case series. (12773449)Ando H.... Mizutani S.2003CGB5
23A chorionic gonadotropin-sensitive mutation in the follicle- stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. (12930927)Vasseur C.... Misrahi M.2003FSHR
24Metabolic characteristics of women who developed ovarian hyperstimulation syndrome. (12151426)Delvigne A.... Rozenberg S.2002MTHFR
25The role of endothelial cells in the pathogenesis of ovarian hyperstimulation syndrome. (11994537)Albert C.... Pellicer A.2002IL6, CGB5
26The questionable use of albumin for the prevention of ovarian hyperstimulation syndrome in an IVF programme: a randomized placebo-controlled trial. (11527892)Ben-Chetrit A.... Margalioth E.J.2001ALB
27Soluble endothelial and platelet selectins in serum a nd ascitic fluid of women with ovarian hyperstimulation syndrome. (11270640)Daniel Y.... Lessing J.B.2001TBX4
28Preliminary study on the role of vascular endothelial growth factor in pathogenesis of ovarian hyperstimulation syndrome (11930688)Zhou C.... Zhuang G.2001VEGFA, CGA
29Combined approach as an effective method in the prevention of severe ovarian hyperstimulation syndrome. (11451550)Isik A.Z.... Vicdan K.2001ALB, CGA
30Intra-venous albumin for preventing severe ovarian hyperstimulation syndrome. (10796765)Aboulghar M.... Al-Inany H.2000ALB, GNRH1
31Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. (10783347)Chen C.D.... Yang Y.S.2000VEGFA
32Plasma immunoglobulins in patients with severe ovarian hyperstimulation syndrome. (9935124)Abramov Y.... Schenker J.G.1999CD79A
33Serum vascular endothelial growth factor levels before starting gonadotropin treatment in women who have developed moderate forms of ovarian hyperstimulation syndrome. (10599547)D'Ambrogio G.... Artini P.G.1999VEGFA
34Haematocrit, leukocyte and platelet counts and the severity of the ovarian hyperstimulation syndrome. (9806258)FA!bregues F.... Vanrell J.A.1998REN
35Ischemic stroke in a young woman with ovarian hyperstimulation syndrome. (9700249)Hwang W.J.... Hou N.T.1998ALB
36Activation of plasma kinin system correlates with severe coagulation disorders in patients with ovarian hyperstimulation syndrome. (9194635)Kodama H.... Tanaka T.1997KLKB1
37Ovarian origin of plasma and peritoneal fluid prorenin in early pregnancy and in patients with ovarian hyperstimulation syndrome. (9024237)Itskovitz-Eldor J.... Sealey J.E.1997REN
38Intravenous albumin does not prevent the development of severe ovarian hyperstimulation syndrome. (9240258)Chen C.D.... Yang Y.S.1997ALB
39Severe ovarian hyperstimulation syndrome: is it really preventable by prophylactic intravenous albumin? (9389814)Ndukwe G.... Aloum M.1997ALB
40Features of the Renin-angiotensin system in ascites a nd pleural effusion during severe ovarian hyperstimulation syndrome. (9147235)Delbaere A.... Englert Y.1997REN
41Prophylactic intravenous albumin for the prevention of severe ovarian hyperstimulation syndrome. (8671246)Orvieto R.... Ben-Rafael Z.1996ALB
42A unilateral hydrothorax as the only manifestation of ovarian hyperstimulation syndrome: a case report. (8941073)Bassil S.... Donnez J.1996ALB
43Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report. (8774285)Krasnow J.S.... Yeo K.T.1996VEGFA
44does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome? (8816633)Lewit N.... Itskovitz-Eldor J.1996ALB
45A severe case of ovarian hyperstimulation syndrome despite the prophylactic administration of intravenous albumin. (7545592)Orvieto R.... Ben-Rafael Z.1995ALB
46Does intravenous albumin prevent ovarian hyperstimulation syndrome? (8046036)Morris R.S.... Paulson R.J.1994ALB
47Intravenous albumin for the prevention of severe ovarian hyperstimulation syndrome in an in vitro fertilization program: a prospective, randomized, placebo-controlled study. (8005278)Shoham Z.... Insler V.1994ALB
48The pathogenesis of the ovarian hyperstimulation syndrome (OHS): a possible role for ovarian renin. (2004471)Ong A.C.... Slater J.D.1991REN
49Triggering ovulation with endogenous luteinizing hormone may prevent the ovarian hyperstimulation syndrome. (1918298)Emperaire J.C.... Ruffie A.1991CGA
50Liver abnormality in ovarian hyperstimulation syndrom e. (1982004)Ryley N.G.... Trowell J.M.1990SLC17A5

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

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36QIAGEN, 10EMD Millipore, 41Thomson Reuters, 37R&D Systems, 20KEGG
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Pathways related to ovarian hyperstimulation syndrome according to GeneDecks:

(show top 50)    (show all 102)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3610.4BMP15, IL2
2NFAT Signaling and Lymphocyte Interactions3610.2BMP15, IL1A, IL2
3Development Role of Activin A in cell differentiation and proliferation1010.1CREB1, SP1, CYP11A1, FSHR, FSHB, CGA
4Development_Role of Activin A in cell differentiation and proliferation4110.1SP1, CYP11A1, FSHR, FSHB, CGA, LHCGR
5Extrinsic Prothrombin Activation Pathway369.9SERPINC1, F3, F5, F2
6Bacterial infections in CF airways419.8CFTR, IL1R1
7Blood Coagulation Signaling Pathways379.7SERPINC1, F5, F3, F2, KLKB1, A2M
8Complement and coagulation cascades209.7F3, F2, SERPINC1, KNG1, F5, A2M
9IL-6 Pathway369.7IL8, IL6R, IL18, BMP15, IL10
10Immune response_Bacterial infections in normal airways419.5CFTR, IL1B, IL1R1
11Regulation of eIF4 and p70S6K369.3BMP15, IL18, IL1A, IL2, IL6
12IP3 Pathway369.0GNRH1, EGFR, IL2, CREB1, FLT1, CD79A
13Transcription_Role of VDR in regulation of genes involved in osteoporosis419.0CGA, IL1A, IL1B, IL6, CYP19A1
14Akt Signaling369.0IL6R, IL6, IL2, IL10, BMP15, IL18
15JNK Pathway368.9IL6, IL2, IL1R1, BMP15, IL6R, FLT1
16PGC1Alpha Pathway368.9IL8, CREB1, IL2, IL1R1, IL1B, IL1A
17African trypanosomiasis208.7F2RL1, IL6, IL1B, IL18, IL10
18Rheumatoid arthritis208.6IL1B, IL1A, VEGFA, IL6, IL8, FLT1
19Molecular Mechanisms of Cancer368.4IL6R, IL6, EGFR, IL2, IL1R1, INSR
20Immune response IL-1 signaling pathway108.3IL1B, IL1A, EDN1, F3, IL8, IL6
21Immune response_IL-1 signaling pathway418.3IL6, IL1R1, IL8, F3, EDN1, IL1A
22Rho Family GTPases368.3INSR, IL8, IL2, IL1B, IL1A, IL10
23eIF2 Pathway368.2INS, IL2, EGFR, GNRH1, IL6, INSR
24Cytokine Network368.2IL18, IL10, IL1A, IL1B, IL2, IL8
25Selected targets of GCR-alpha108.2FSHB, INSR, IL1B, INS, IL8, CGA
26Estrogen Pathway368.0IL2, FLT1, CREB1, EGFR, GNRH1, INSR
27MIF Mediated Glucocorticoid Regulation368.0IL6, IL10, IL8, IL1B, IL18, BMP15
28MIF Regulation of Innate Immune Cells368.0IL1A, BMP15, IL2, IL1B, IL6, IL18
29all-trans-Retinoic Acid Signaling in Brain368.0IL8, IL6, IL1B, IL2, IL18, IL10
30Malaria208.0IL8, IL1B, IL6, IL18, IL10
31PEDF Induced Signaling368.0IL8, IL2, IL1B, IL1A, BMP15, IL18
32Renin-Angiotensin Pathway367.9REN, FLT1, KDR, IL6, GNRH1, EGFR
33NF-KappaB (p50-p65) Pathway367.9EGFR, GNRH1, IL6, IL1R1, IL1B, IL1A
34NF-KappaB Family Pathway367.8IL6, KDR, IL1R1, IL2, GNRH1, IL1B
35STAT3 Pathway367.7IL8, IL6R, IL6, IL2, IL1R1, IL1B
36Chagas disease (American trypanosomiasis)207.7IL10, IL2, IL6, IL8, ACE, IL1B
37p70S6K Signaling367.7INSR, INS, F2, KDR, FLT1, IL6
38Glucocorticoid Receptor Signaling367.6IL6, IL1B, IL1R1, IL2, IL6R, IL1A
39SOCS Pathway367.4IL10, INSR, IL8, BMP15, IL18, IL1A
40MAPK Signaling367.4FLT1, INSR, IL1A, IL1R1, IL2, IL6
41Endothelin-1 Signaling Pathway367.2EGFR, EDN1, IL6, IL2, FLT1, INSR
42ERK Signaling367.1FLT1, INSR, IL10, IL1A, IL1B, IL2
43PAK Pathway367.1IL6, BMP15, KDR, IL8, FLT1, IL10
44Tec Kinases Signaling366.9BMP15, INSR, IL10, IL18, IL1B, IL2
45TGF-Beta Pathway366.8IL18, IL10, FLT1, KDR, BMP15, IL1A
46Antioxidant Action of Vitamin-C366.8IL18, IL1R1, IL1B, IL1A, IL6R, IL10
47MAPK Family Pathway366.6IL1R1, FLT1, EGFR, CREB1, GNRH1, IL8
48Cytokine-cytokine receptor interaction206.4IL2, IL8, IL6, KDR, IL1R1, VEGFA
49p38 Signaling366.3SP1, GNRH1, IL8, IL6R, IL6, IL2
50JAK-STAT Pathway366.2BMP15, SP1, KDR, FLT1, INSR, IL10

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

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32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to ovarian hyperstimulation syndrome according to GeneDecks:

(show top 50)    (show all 452)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.6APOH
2aprotinin32 9 9 12.0KLKB1, F2, F5, IL1A, SERPINC1
3polyethylene glycol32 9.9INSR, BCHE, SERPINC1, NPPA
4endotoxin32 9.5IL18, AZU1, IL1R1, SLC17A5, KLKB1, F2RL1
5mifepristone32 42 9 9 12.3CREB1, SP1, CYP19A1, GNRH1, AMH, IL8
6pge132 9.1SLC17A5, NPPA, CREB1, F5, APOH, IL1A
7estradiol32 9 18 9 12.1CREB1, REN, LHCGR, CGA, CGB5, CYP19A1
8progesterone32 42 9 18 9 13.1CGB5, CGA, LHCGR, BMP15, FSHB, FSHR
9heparin32 9 18 9 12.0KNG1, A2M, KLKB1, BCHE, GNRH1, ALB
10progestin32 8.9CYP19A1, CYP11A1, GNRH1, F5, INSR, CGB5
11kininogen32 8.9NPPA, ACE, KLKB1, ALB, F2, F3
12histamine32 18 9.9ALB, F2RL1, IL6R, IL2, IL18, CDH5
13ramipril32 9 9 10.7BCHE, CD79A, INS, ALB, ACE, NPPA
14sb 20358032 42 9.6EDN1, CREB1, F2RL1, IL6, IL1R1, INSR
15n acetylcysteine32 8.6IL1R1, IL18, CD79A, CFTR, KDR, SERPINC1
16gnrh32 8.6SHBG, CREB1, SP1, CYP11A1, INS, FSHR
17pge232 8.2KNG1, EGFR, EDN1, CREB1, CYP19A1, F2RL1
18tamoxifen32 34 9 9 11.2SLC17A5, EGFR, SHBG, SP1, CYP19A1, GNRH1
19rapamycin32 42 9.2NPPA, EGFR, SP1, IL2, IL1R1, VEGFA
20aspirin32 34 18 9.9KNG1, ACE, F2, F3, SERPINC1, BCHE
21metformin32 34 9 9 10.8SLC17A5, ACE, EGFR, SHBG, CYP19A1, CYP11A1
22glutamate32 7.7SP1, GNRH1, F2RL1, APOH, IL1R1, KDR
23ibmx32 7.6INSR, CGA, CGB5, CFTR, INS, IL1B
24vegf32 7.5KDR, INSR, FLT1, CDH5, AZU1, CGB5
25acetylcholine32 9 18 9 10.5GNRH1, SP1, F2RL1, IL1A, BCHE, LEP
26neopterin32 7.5SLC17A5, CD79A, IL8, IL6R, IL6, IL2
27simvastatin32 34 42 9 18 9 12.5SHBG, SP1, F2, F3, F5, IL8
28acth32 7.5GNRH1, REN, IL6, IL1R1, IL1B, IL1A
29creatinine32 7.4IL18, FLT1, CD79A, CGB5, CGA, MTHFR
30epinephrine32 9 18 9 10.3SLC17A5, CFTR, CGB5, CGA, LEP, REN
31testosterone32 9 18 9 10.2EGFR, SHBG, CREB1, SP1, CYP11A1, CGA
32lactate32 7.1IL18, INS, CD79A, CGB5, CGA, BCHE
33indomethacin32 9 9 9.0CD79A, CFTR, CGB5, CGA, LEP, KDR
34fibrinogen32 6.9SERPINC1, IL18, F2RL1, SLC17A5, A2M, KLKB1
35methotrexate32 34 42 9 9 10.9IL6R, LEP, IL6, IL1R1, IL1B, IL18
36arginine32 6.8KNG1, EDN1, SHBG, CD79A, AZU1, CGB5
37prostacyclin32 6.7KNG1, INSR, FLT1, CGA, LEP, KDR
38estrogen32 6.6FSHR, FSHB, CFTR, CGB5, CGA, MTHFR
39hydrocortisone32 9 9 8.6SHBG, FLT1, CDH5, KDR, REN, INS
40cholesterol32 9 18 9 9.5REN, APOH, IL6R, IL6, IL1R1, IL18
41actinomycin d32 6.5VEGFA, CGA, IL8, IL6, IL2, IL1R1
42thymidine32 18 7.4FLT1, MTHFR, AZU1, FSHR, INSR, IL10
43alanine32 6.3SLC17A5, SHBG, SP1, GNRH1, ALB, F2RL1
44genistein32 9 18 9 8.9CYP19A1, VEGFA, KDR, CGB5, CFTR, F2RL1
45cyclosporin a32 42 6.8NPPA, EDN1, GNRH1, F2RL1, F2, IL8
46norepinephrine32 9 18 9 8.8KNG1, SLC17A5, NPPA, ACE, EDN1, CFTR
47nitric oxide32 9 18 9 8.7IL1R1, IL1B, IL1A, IL18, IL10, FLT1
48cycloheximide32 5.0KNG1, IL1R1, IL1B, IL1A, IL18, IL10
49dexamethasone32 42 34 9 9 8.9CYP19A1, CYP11A1, GNRH1, F2RL1, IL8, IL6R
50serine32 4.8KNG1, EGFR, A2M, KLKB1, CREB1, SP1

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

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Sources:
12Gene Ontology
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Cellular components related to ovarian hyperstimulation syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.9KNG1, A2M, ALB, F5, VEGFA
2endosomeGO:0057689.0LHCGR, FSHR, FLT1, EGFR, ACE
3plasma membraneGO:0058866.3F5, F3, F2, F2RL1, RHCG, KLKB1
4extracellular regionGO:0055764.8KNG1, IL1R1, IL1B, IL1A, IL18, INS
5extracellular spaceGO:0056153.3KNG1, ACE, IL1B, IL1A, IL18, IL10

Biological processes related to ovarian hyperstimulation syndrome according to GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte chemotaxisGO:00269010.7F2RL1
2ovarian follicle developmentGO:00154110.4FSHB, LHCGR, KDR, BMP15
3positive regulation of positive chemotaxisGO:05092710.4F2RL1, F3, KDR, VEGFA
4cellular response to vascular endothelial growth factor stimulusGO:03592410.4FLT1, KDR, VEGFA
5platelet degranulationGO:00257610.3KNG1, A2M, ALB, F5, VEGFA
6female gamete generationGO:00729210.3BMP15, FSHB, FSHR
7induction of positive chemotaxisGO:05093010.3IL8, AZU1, VEGFA
8cellular response to fibroblast growth factor stimulusGO:04434410.2CYP19A1, CYP11A1, IL8
9negative regulation of blood coagulationGO:03019510.1KNG1, EDN1, APOH
10response to L-ascorbic acidGO:03359110.1IL1A, IL1B, CYP11A1
11blood coagulation, intrinsic pathwayGO:00759710.0KNG1, A2M, KLKB1, F2, APOH
12female pregnancyGO:00756510.0NPPA, GNRH1, FLT1, FSHB, LEP
13cellular response to tumor necrosis factorGO:07135610.0IL18, IL8, CYP11A1, EDN1
14positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.9IL1B, FLT1, VEGFA
15positive regulation of angiogenesisGO:0457669.7F3, IL1B, IL1A, FLT1, KDR, VEGFA
16positive regulation of chemokine productionGO:0327229.7IL6R, IL6, IL18
17positive regulation of MAP kinase activityGO:0434069.7EGFR, EDN1, FLT1, VEGFA
18positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.6F2RL1, F2, INS, FLT1, KDR
19defense response to Gram-negative bacteriumGO:0508299.6IL6R, IL6, AZU1
20monocyte chemotaxisGO:0025489.6IL6R, IL6, FLT1
21hepatic immune responseGO:0023849.6IL6, IL6R
22elevation of cytosolic calcium ion concentrationGO:0072049.5KNG1, EDN1, F2RL1, IL2, IL1B
23regulation of blood pressureGO:0082179.5NPPA, ACE, LEP, REN
24blood coagulationGO:0075969.5KNG1, A2M, KLKB1, ALB, F2RL1, F2
25positive regulation of smooth muscle cell proliferationGO:0486619.4EDN1, IL6R, IL6, FLT1
26regulation of sensory perception of painGO:0519309.4EDN1, IL1A, IL10
27positive regulation of mitosisGO:0458409.3EDN1, IL1B, IL1A, INSR, INS
28positive regulation of interleukin-6 productionGO:0327559.3IL1A, IL1B, IL6, IL6R
29response to drugGO:0424939.3BCHE, LHCGR, IL10, AMH, CYP11A1, CYP19A1
30platelet activationGO:0301689.2KNG1, A2M, ALB, F2, F5, IL6
31response to hypoxiaGO:0016669.2EDN1, IL1B, IL1A, IL18, FLT1, LEP
32G-protein coupled receptor signaling pathwayGO:0071869.2EDN1, F2RL1, IL8, INSR, INS, FSHR
33positive regulation of protein kinase B signaling cascadeGO:0518979.2EGFR, F3, INSR, INS
34acute-phase responseGO:0069539.1INS, IL6, IL6R, F2
35anti-apoptosisGO:0069169.0GNRH1, F3, IL2, IL1B, IL1A, IL10
36positive regulation of nitric oxide biosynthetic processGO:0454298.9EGFR, EDN1, IL1B, INSR, INS
37positive regulation of NF-kappaB transcription factor activityGO:0510928.9AMH, IL6R, IL6, IL1B, INS
38response to glucocorticoid stimulusGO:0513848.8IL6, IL1B, IL10, INSR, BCHE
39MAPK cascadeGO:0001658.8INS, IL18, IL1B, EGFR
40positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.7VEGFA, INS, IL6, IL6R
41positive regulation of MAPK cascadeGO:0434108.7IL6R, IL6, INSR, INS, FLT1, LEP
42cell-cell signalingGO:0072678.5EDN1, GNRH1, AMH, IL2, IL1B, IL18
43positive regulation of cell migrationGO:0303358.5VEGFA, EGFR, EDN1, F2RL1, F3, INSR
44positive regulation of transcription from RNA polymerase II promoterGO:0459448.4CREB1, SP1, F2RL1, IL6, IL2, IL1B
45negative regulation of apoptotic processGO:0430668.2EGFR, ALB, IL6, INS, LEP, KDR
46inflammatory responseGO:0069548.0KNG1, AZU1, IL10, IL18, IL1A, IL1B
47positive regulation of cell proliferationGO:0082847.0IL2, IL6, IL6R, F2, EDN1, EGFR

Molecular functions related to ovarian hyperstimulation syndrome according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.8SERPINC1, VEGFA, AZU1, APOH, KNG1
2receptor signaling protein tyrosine kinase activityGO:0047169.7EGFR, INSR, KDR
3insulin-like growth factor receptor bindingGO:0051599.6REN, INS, INSR
4receptor bindingGO:0051029.4KNG1, NPPA, F2RL1, F2, AMH, CDH5
5hormone activityGO:0051799.1LEP, NPPA, EDN1, GNRH1, AMH, INS
6protease bindingGO:0020209.0F3, IL1R1, INS, SERPINC1
7cytokine activityGO:0051257.8EDN1, IL6, IL2, IL1B, IL1A, IL18
8growth factor activityGO:0080837.6F2, AMH, IL6, IL2, IL1B, IL10
9protein bindingGO:0055155.2F2RL1, F2, F3, F5, APOH, ALB

Sources for Ovarian Hyperstimulation Syndrome

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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