OHSS
MCID: OVR029
MIFTS: 67

Ovarian Hyperstimulation Syndrome (OHSS) malady

Genetic diseases, Reproductive diseases, Rare diseases categories
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Summaries for Ovarian Hyperstimulation Syndrome

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Wikipedia:65 Ovarian hyperstimulation syndrome (OHSS) is a medical condition affecting the ovaries of some women... more...

MalaCards based summary: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to hypothyroidism and polycystic ovary syndrome, and has symptoms including An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Transcription CREM signaling in testis and Selected targets of GCR alpha. The drugs ganirelix and ganirelix acetate and the compounds altrenogest and pergonal have been mentioned in the context of this disorder. Affiliated tissues include endothelial, ovary and pituitary, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:46 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

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Sources:
8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Ovarian Hyperstimulation Syndrome, Aliases & Descriptions:

Name: Ovarian Hyperstimulation Syndrome 8 9 20 22 46 10 44 48 62
Secondary Meig's Syndrome 8
 
Ohss 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:5425
OMIM46 608115
MeSH34 D016471
SNOMED-CT57 129635004
MESH via Orphanet35 D016471
ICD10 via Orphanet26 N98.1
UMLS via Orphanet63 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

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Diseases related to Ovarian Hyperstimulation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism31.2CGA, FSHR
2polycystic ovary syndrome31.1GNRH1, CGA, FSHR
3ovarian cyst31.1GNRH1, CGA
4hyperprolactinemia30.7GNRH1, CGA
5pituitary adenoma30.7FSHB, GNRH1, CGA, FSHR
6ovarian disease30.6GNRH1, FSHR, CGA
7adenoma30.5CGA, REN, FSHR, FSHB, GNRH1
8infertility30.4GNRH1, FSHB, FSHR, CGA
9pregnancy loss30.4CGA, F5, GNRH1
10hypogonadism30.2GNRH1, FSHB, FSHR, CGA
11endotheliitis11.0
12peritonitis10.5
13thrombophilia10.5
14ectopic pregnancy10.5
15thromboembolism10.5
16pulmonary edema10.4
17cerebritis10.4
18blindness10.4
19retinal vascular occlusion10.4F5
20dysfibrinogenemia10.4F5
21endophthalmitis10.4VEGFA
22diabetic macular edema10.4VEGFA
23duodenal ulcer10.3
24duodenitis10.3
25breast cancer10.3
26thyroiditis10.3
27vaginitis10.3
28venous thrombosis10.3
29amenorrhea10.3FSHR, GNRH1
30gonadal disease10.3GNRH1, FSHR
31hypothalamic disease10.3CGA, GNRH1
32penis agenesis10.3GNRH1, CGA
33varicocele10.3GNRH1, CGA
34aorta atresia10.3CGA, GNRH1
35gynecomastia10.3GNRH1, CGA
36premature ovarian failure10.3FSHR, GNRH1
37kallmann syndrome10.3GNRH1, CGA
38hypopituitarism10.3CGA, GNRH1
39cryptorchidism10.2GNRH1, CGA
40leydig cell tumor10.2GNRH1, CGA
41klinefelter's syndrome10.2GNRH1, CGA
42congenital adrenal hyperplasia10.2REN, GNRH1
43adult respiratory distress syndrome10.2
44cystic fibrosis10.2
45hepatitis10.2
46systemic lupus erythematosus10.2
47anuria10.2
48central retinal artery occlusion10.2
49von willebrand's disease10.2
50appendicitis10.2

Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Symptoms for Ovarian Hyperstimulation Syndrome

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Symptoms by clinical synopsis from OMIM:

608115

Clinical features from OMIM:

608115

HPO human phenotypes related to Ovarian Hyperstimulation Syndrome:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the genitourinary system HP:0000119
3 ascites HP:0001541
4 nausea HP:0002018
5 abdominal pain HP:0002027

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

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Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Ovarian Hyperstimulation Syndrome

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Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome20 22 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

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MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

32
Endothelial, Ovary, Pituitary, Liver, Thyroid, Breast, Bone, Lymph node, Kidney, Myeloid

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Ovarian Hyperstimulation Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6F5, FSHR, GNRH1, VEGFA
2MP:00020068.3VEGFA, GNRH1, FSHR, ALB
3MP:00053708.0F5, ALB, GNRH1, VEGFA
4MP:00053897.9VEGFA, GNRH1, FSHB, FSHR, REN, CGA
5MP:00053677.9VEGFA, GNRH1, REN, ALB
6MP:00036317.9VEGFA, GNRH1, FSHR, REN, F5, CGA
7MP:00053787.8VEGFA, GNRH1, FSHR, REN, F5, CGA
8MP:00053797.6VEGFA, GNRH1, FSHB, FSHR, ALB, CGA
9MP:00053766.6CGA, VEGFA, GNRH1, FSHB, FSHR, REN

Publications for Ovarian Hyperstimulation Syndrome

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Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Thrombosis following ovarian hyperstimulation syndrome. (25014487)
2014
2
Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman. (24971660)
2014
3
Ovarian Hyperstimulation Syndrome and Arterial Stroke. (25395409)
2014
4
GnRH agonist trigger and ovarian hyperstimulation syndrome: relook at 'freeze-all strategy'. (25042608)
2014
5
The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. (23295464)
2013
6
Cabergoline as treatment of ovarian hyperstimulation syndrome: a review. (23110560)
2013
7
Management of severe ovarian hyperstimulation syndrome with thawed plasma. (23869160)
2013
8
Spontaneous ovarian hyperstimulation syndrome. (23941020)
2013
9
Comparison of bevacizumab and cabergoline in the treatment of ovarian hyperstimulation syndrome in a rat model. (23862585)
2013
10
Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. (23883350)
2013
11
Multiple transvaginal ascitic fluid aspirations improves the clinical and reproductive outcome in patients undergoing in vitro fertilisation treatment complicated by severe early ovarian hyperstimulation syndrome. (22519486)
2012
12
Spontaneous bacterial peritonitis complicating ovarian hyperstimulation syndrome-related ascites. (22189746)
2011
13
Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome. (21269615)
2011
14
Spontaneous ovarian hyperstimulation syndrome (OHSS): a rare but important differential diagnosis for abdominal distension in early pregnancy. (21534759)
2011
15
Heterotopic triplet pregnancy complicated with ovarian hyperstimulation syndrome following in vitro fertilization. (22649892)
2011
16
Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis. (21168129)
2011
17
A case of spontaneous ovarian hyperstimulation syndrome. (21353368)
2011
18
New insights of osmoregulatory system changes in ovarian hyperstimulation syndrome. (20850728)
2011
19
Ovarian hyperstimulation syndrome: pathophysiology and prevention. (20140640)
2010
20
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. (17721928)
2008
21
Ischaemic stroke with ovarian hyperstimulation syndrome. (18988418)
2008
22
Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome. (17356124)
2007
23
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
24
No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome. (16391898)
2006
25
Coasting for the prevention of ovarian hyperstimulation syndrome: much ado about nothing? (16500317)
2006
26
Spontaneous ovarian hyperstimulation syndrome in a normal singleton pregnancy. (17175480)
2006
27
Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). (16788381)
2006
28
Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester. (15618246)
2005
29
Prevention of ovarian hyperstimulation syndrome by early aspiration of small follicles in hyper-responsive patients with polycystic ovaries during assisted reproductive treatment cycles. (16369286)
2005
30
Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard? (15957998)
2005
31
Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. (14711532)
2004
32
Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome. (15212675)
2004
33
Severity of ovarian hyperstimulation syndrome: its relation to number of conceptuses. (15038508)
2004
34
Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. (15066453)
2004
35
Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study. (14585874)
2003
36
Clinical and laboratory evaluation of hospitalized patients with severe ovarian hyperstimulation syndrome. (12831592)
2003
37
Prediction of ovarian hyperstimulation syndrome. Challenging the estradiol mythos. (12660254)
2003
38
Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review. (12407029)
2002
39
Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception. (12477503)
2002
40
Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization. (12036082)
2002
41
Bilateral jugular venous thromboembolism and pulmonary emboli in a patient with severe ovarian hyperstimulation syndrome. (11721733)
2001
42
Ovarian hyperstimulation syndrome: an endocrinopathy? (11396659)
2001
43
Perforated duodenal ulcer associated with ovarian hyperstimulation syndrome: Case Report. (11139559)
2001
44
Does intravenous albumin prevent severe ovarian hyperstimulation syndrome? (9988419)
1999
45
does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome? (8816633)
1996
46
A severe case of ovarian hyperstimulation syndrome despite the prophylactic administration of intravenous albumin. (7545592)
1995
47
Use of GnRH analog for induction of the ovulatory surge of gonadotropins in patients at risk of the ovarian hyperstimulation syndrome. (7502696)
1995
48
Intravenous albumin and the prevention of severe ovarian hyperstimulation syndrome. (8567807)
1995
49
Does intravenous albumin prevent ovarian hyperstimulation syndrome? (8046036)
1994
50
Triggering ovulation with endogenous luteinizing hormone may prevent the ovarian hyperstimulation syndrome. (1918298)
1991

Variations for Ovarian Hyperstimulation Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Ovarian Hyperstimulation Syndrome:

64
id Symbol AA change Variation ID SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Clinvar genetic disease variations for Ovarian Hyperstimulation Syndrome:

6
id Gene Name Type Significance SNP ID Assembly Location
1FSHRNM_000145.3(FSHR): c.2039G> A (p.Ser680Asn)single nucleotide variantdrug responsers6166GRCh37Chr 2, 49189921: 49189921
2FSHRNM_000145.3(FSHR): c.1346C> T (p.Thr449Ile)single nucleotide variantPathogenicrs28928870GRCh37Chr 2, 49190614: 49190614
3FSHRNM_000145.3(FSHR): c.1699G> A (p.Asp567Asn)single nucleotide variantPathogenicrs28928871GRCh37Chr 2, 49190261: 49190261
4FSHRNM_000145.3(FSHR): c.1345A> G (p.Thr449Ala)single nucleotide variantPathogenicrs121909663GRCh37Chr 2, 49190615: 49190615
5FSHRNM_000145.3(FSHR): c.1634T> C (p.Ile545Thr)single nucleotide variantPathogenicrs121909664GRCh37Chr 2, 49190326: 49190326
6FSHRNM_000145.3(FSHR): c.383C> A (p.Ser128Tyr)single nucleotide variantPathogenicrs121909665GRCh37Chr 2, 49217768: 49217768

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

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Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

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Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FSHB, FSHR
29.6CGA, FSHB
3
Show member pathways
9.2FSHB, CGA, FSHR
49.2FSHB, FSHR, CGA
59.2FSHB, FSHR, CGA
69.2CGA, FSHR, FSHB
7
Show member pathways
9.2FSHB, CGA, GNRH1
8
Show member pathways
9.1CGA, FSHB, REN
9
Show member pathways
8.8FSHB, FSHR, CGA, GNRH1
108.8GNRH1, CGA, FSHR, FSHB
11
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5VEGFA, GNRH1, FSHB, CGA
12
Show member pathways
8.5F5, ALB, VEGFA
13
Show member pathways
8.5ALB, F5, VEGFA
14
Show member pathways
8.2FSHR, VEGFA, CGA, FSHB, GNRH1

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

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Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1altrenogest4410.1CGA, GNRH1
2pergonal4410.1GNRH1, CGA
3deslorelin4410.1GNRH1, CGA
4metrodin4410.0CGA, GNRH1
5antarelix44 2811.0CGA, GNRH1
6d-trp6-lhrh449.9GNRH1, CGA
7metoclopramide44 50 1111.6REN, GNRH1, CGA
817-hydroxyprogesterone44 2410.6REN, GNRH1, CGA
9ganirelix44 2810.6CGA, FSHB, GNRH1
10leuprolide acetate449.6CGA, GNRH1, FSHB
11buserelin44 28 1111.6GNRH1, FSHB, CGA
12clomiphene citrate449.6FSHB, GNRH1, CGA
13nafarelin44 61 28 1112.6GNRH1, CGA
14ornipressin449.6ALB, REN
15cyproteroneacetate449.5F5, GNRH1, REN
16metformin44 50 1111.4CGA, F5, GNRH1
1751-cr-edta449.4ALB, REN
18deoxyribonucleic acid449.4FSHB, FSHR, F5
19indapamide44 1110.4REN, ALB
20androstenedione44 2410.3GNRH1, FSHR, CGA, REN
21organon449.3CGA, FSHB
22gnrh449.2FSHR, CGA, GNRH1, FSHB
23naloxone44 28 50 1112.2CGA, ALB, GNRH1
24terlipressin44 1110.2REN, ALB
25spironolactone44 61 28 50 1113.2REN, GNRH1, ALB
26ribonucleic acid449.2CGA, FSHR, FSHB, GNRH1
27mifepristone44 28 61 1112.1CGA, VEGFA, GNRH1
28epinephrine44 24 1111.1CGA, F5, REN, GNRH1
29lisinopril44 50 24 1112.0ALB, REN, VEGFA
30perindopril44 50 1111.0ALB, VEGFA, REN
31halothane44 50 28 1112.0REN, ALB, F5
32progestin449.0CGA, F5, VEGFA, GNRH1
33candesartan44 50 28 1112.0VEGFA, ALB, REN
34kininogen449.0ALB, REN, F5
35prostacyclin448.9REN, F5, CGA, VEGFA
36tamoxifen44 50 28 1111.9CGA, VEGFA, GNRH1, F5
37thyroxine44 249.8ALB, REN, CGA, GNRH1
38pge2448.8VEGFA, FSHR, REN, CGA
39celecoxib44 61 28 50 24 1113.8VEGFA, ALB, REN
40actinomycin d448.8CGA, FSHB, GNRH1, VEGFA
41progesterone44 28 61 24 1112.7FSHB, FSHR, F5, GNRH1, CGA
42lactate448.5CGA, F5, ALB, GNRH1
43aspartate448.3CGA, GNRH1, ALB, F5
44alanine448.3FSHR, ALB, F5, CGA, GNRH1
45creatinine448.3F5, CGA, ALB, REN, GNRH1
46steroid448.3GNRH1, FSHB, FSHR, REN, F5, CGA
47heparin44 28 24 1111.1CGA, ALB, GNRH1, VEGFA, F5
48estrogen448.1GNRH1, VEGFA, CGA, F5, FSHB, FSHR
49estradiol44 24 1110.0CGA, GNRH1, FSHB, FSHR, REN, ALB
50testosterone44 61 24 1110.9GNRH1, FSHB, FSHR, ALB, F5, CGA

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

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Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.2ALB, F5, VEGFA
2extracellular spaceGO:0056157.6REN, GNRH1, VEGFA, ALB, F5
3extracellular regionGO:0055766.6CGA, F5, ALB, REN, FSHB, GNRH1

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1gonad developmentGO:00840610.0FSHR, CGA
2regulation of MAPK cascadeGO:0434089.9FSHR, REN
3Sertoli cell proliferationGO:0600119.9FSHR, FSHB
4regulation of osteoclast differentiationGO:0456709.9FSHB, FSHR
5female gamete generationGO:0072929.9FSHR, FSHB
6peptide hormone processingGO:0164869.8CGA, FSHB
7cell maturationGO:0484699.6REN, VEGFA
8male gonad developmentGO:0085849.6FSHR, REN
9kidney developmentGO:0018229.4REN, VEGFA
10female pregnancyGO:0075659.2FSHB, GNRH1
11positive regulation of cell migrationGO:0303359.2CGA, FSHB, VEGFA
12cellular protein metabolic processGO:0442679.1CGA, REN, FSHB
13positive regulation of cell proliferationGO:0082849.1CGA, FSHB, VEGFA
14platelet degranulationGO:0025768.8F5, ALB, VEGFA
15negative regulation of apoptotic processGO:0430668.7VEGFA, GNRH1, ALB
16platelet activationGO:0301688.7F5, ALB, VEGFA
17blood coagulationGO:0075968.6VEGFA, ALB, F5

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.1F5, ALB
2hormone activityGO:0051798.9CGA, FSHB, GNRH1

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

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Sources for Ovarian Hyperstimulation Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet