OHSS
MCID: OVR029
MIFTS: 66

Ovarian Hyperstimulation Syndrome (OHSS) malady

Genetic diseases, Reproductive diseases, Rare diseases categories

Summaries for Ovarian Hyperstimulation Syndrome

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication,... more...

MalaCards: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to polycystic ovary syndrome and hypothyroidism. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Transcription CREM signaling in testis and Selected targets of GCR alpha. The drugs ganirelix and ganirelix acetate and the compounds altrenogest and pergonal have been mentioned in the context of this disorder. Affiliated tissues include endothelial, ovary and pituitary, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:48 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

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9Disease Ontology, 10diseasecard, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

ovarian hyperstimulation syndrome 9 10 21 23 48 11 46 50 63
secondary meig's syndrome 9
ohss 50


External Ids:

Disease Ontology9 DOID:5425
OMIM48 608115
MeSH36 D016471
MESH via Orphanet37 D016471
SNOMED-CT59 129635004
ICD10 via Orphanet27 N98.1
SNOMED-CT via Orphanet60 129635004
UMLS via Orphanet64 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Symptoms for Ovarian Hyperstimulation Syndrome

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48OMIM
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Symptoms by clinical synopsis from OMIM:

608115

Clinical features from OMIM:

608115

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Ovarian Hyperstimulation Syndrome

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21GeneTests, 23GTR
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Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome21 23 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

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34MalaCards
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MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

34
Endothelial, Ovary, Pituitary, Liver, Breast, Thyroid, Kidney, Myeloid, Lymph node, Bone

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ovarian Hyperstimulation Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6F5, FSHR, GNRH1, VEGFA
2MP:00020068.3VEGFA, GNRH1, FSHR, ALB
3MP:00053708.0F5, ALB, GNRH1, VEGFA
4MP:00053897.9VEGFA, GNRH1, FSHB, FSHR, REN, CGA
5MP:00053677.9VEGFA, GNRH1, REN, ALB
6MP:00036317.9VEGFA, GNRH1, FSHR, REN, F5, CGA
7MP:00053787.8VEGFA, GNRH1, FSHR, REN, F5, CGA
8MP:00053797.6VEGFA, GNRH1, FSHB, FSHR, ALB, CGA
9MP:00053766.6CGA, VEGFA, GNRH1, FSHB, FSHR, REN

Publications for Ovarian Hyperstimulation Syndrome

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53PubMed
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Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. (23295464)
2013
2
Cabergoline as treatment of ovarian hyperstimulation syndrome: a review. (23110560)
2013
3
Management of severe ovarian hyperstimulation syndrome with thawed plasma. (23869160)
2013
4
Spontaneous ovarian hyperstimulation syndrome. (23941020)
2013
5
Comparison of bevacizumab and cabergoline in the treatment of ovarian hyperstimulation syndrome in a rat model. (23862585)
2013
6
Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. (23883350)
2013
7
Successful pregnancy complicated by spontaneous, familial, recurrent ovarian hyperstimulation syndrome: report of two cases. (23952048)
2013
8
Multiple transvaginal ascitic fluid aspirations improves the clinical and reproductive outcome in patients undergoing in vitro fertilisation treatment complicated by severe early ovarian hyperstimulation syndrome. (22519486)
2012
9
Spontaneous bacterial peritonitis complicating ovarian hyperstimulation syndrome-related ascites. (22189746)
2011
10
Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome. (21269615)
2011
11
Spontaneous ovarian hyperstimulation syndrome (OHSS): a rare but important differential diagnosis for abdominal distension in early pregnancy. (21534759)
2011
12
Heterotopic triplet pregnancy complicated with ovarian hyperstimulation syndrome following in vitro fertilization. (22649892)
2011
13
Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis. (21168129)
2011
14
A case of spontaneous ovarian hyperstimulation syndrome. (21353368)
2011
15
New insights of osmoregulatory system changes in ovarian hyperstimulation syndrome. (20850728)
2011
16
Ovarian hyperstimulation syndrome: pathophysiology and prevention. (20140640)
2010
17
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. (17721928)
2008
18
Ischaemic stroke with ovarian hyperstimulation syndrome. (18988418)
2008
19
Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome. (17356124)
2007
20
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
21
No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome. (16391898)
2006
22
Coasting for the prevention of ovarian hyperstimulation syndrome: much ado about nothing? (16500317)
2006
23
Spontaneous ovarian hyperstimulation syndrome in a normal singleton pregnancy. (17175480)
2006
24
Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). (16788381)
2006
25
Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester. (15618246)
2005
26
Prevention of ovarian hyperstimulation syndrome by early aspiration of small follicles in hyper-responsive patients with polycystic ovaries during assisted reproductive treatment cycles. (16369286)
2005
27
Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard? (15957998)
2005
28
Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. (14711532)
2004
29
Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome. (15212675)
2004
30
Severity of ovarian hyperstimulation syndrome: its relation to number of conceptuses. (15038508)
2004
31
Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. (15066453)
2004
32
Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study. (14585874)
2003
33
Clinical and laboratory evaluation of hospitalized patients with severe ovarian hyperstimulation syndrome. (12831592)
2003
34
Prediction of ovarian hyperstimulation syndrome. Challenging the estradiol mythos. (12660254)
2003
35
Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review. (12407029)
2002
36
Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception. (12477503)
2002
37
Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization. (12036082)
2002
38
Bilateral jugular venous thromboembolism and pulmonary emboli in a patient with severe ovarian hyperstimulation syndrome. (11721733)
2001
39
Ovarian hyperstimulation syndrome: an endocrinopathy? (11396659)
2001
40
Perforated duodenal ulcer associated with ovarian hyperstimulation syndrome: Case Report. (11139559)
2001
41
Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program. (11447736)
2001
42
Does intravenous albumin prevent severe ovarian hyperstimulation syndrome? (9988419)
1999
43
Plasma immunoglobulins in patients with severe ovarian hyperstimulation syndrome. (9935124)
1999
44
The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome. (9687159)
1998
45
Bilateral internal jugular venous thrombosis complicating severe ovarian hyperstimulation syndrome after prophylactic albumin administration. (9207607)
1997
46
does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome? (8816633)
1996
47
Use of GnRH analog for induction of the ovulatory surge of gonadotropins in patients at risk of the ovarian hyperstimulation syndrome. (7502696)
1995
48
Intravenous albumin and the prevention of severe ovarian hyperstimulation syndrome. (8567807)
1995
49
Does intravenous albumin prevent ovarian hyperstimulation syndrome? (8046036)
1994
50
Triggering ovulation with endogenous luteinizing hormone may prevent the ovarian hyperstimulation syndrome. (1918298)
1991

Variations for Ovarian Hyperstimulation Syndrome

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Ovarian Hyperstimulation Syndrome:

65
id Symbol AA change Variation ID SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Clinvar genetic disease variations for Ovarian Hyperstimulation Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1FSHRNM_000145.3(FSHR): c.1346C> T (p.Thr449Ile)single nucleotide variantPathogenicrs28928870GRCh37Chr 2, 49190614: 49190614
2FSHRNM_000145.3(FSHR): c.1699G> A (p.Asp567Asn)single nucleotide variantPathogenicrs28928871GRCh37Chr 2, 49190261: 49190261
3FSHRNM_000145.3(FSHR): c.1345A> G (p.Thr449Ala)single nucleotide variantPathogenicrs121909663GRCh37Chr 2, 49190615: 49190615
4FSHRNM_000145.3(FSHR): c.1634T> C (p.Ile545Thr)single nucleotide variantPathogenicrs121909664GRCh37Chr 2, 49190326: 49190326
5FSHRNM_000145.3(FSHR): c.383C> A (p.Ser128Tyr)single nucleotide variantPathogenicrs121909665GRCh37Chr 2, 49217768: 49217768

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

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51PathCards, 61Thomson Reuters, 13EMD Millipore, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FSHB, FSHR
29.6CGA, FSHB
39.2FSHB, FSHR, CGA
4
Show member pathways
9.2CGA, FSHR, FSHB
59.2CGA, FSHR, FSHB
69.2CGA, FSHR, FSHB
7
Show member pathways
9.2CGA, FSHB, GNRH1
8
Show member pathways
9.1FSHB, REN, CGA
9
Show member pathways
8.8CGA, FSHR, FSHB, GNRH1
108.8CGA, FSHR, FSHB, GNRH1
11
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.5VEGFA, GNRH1, FSHB, CGA
12
Show member pathways
8.5VEGFA, ALB, F5
13
Show member pathways
8.5F5, ALB, VEGFA
14
Show member pathways
8.2VEGFA, GNRH1, FSHB, FSHR, CGA

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1altrenogest4610.1CGA, GNRH1
2pergonal4610.1GNRH1, CGA
3deslorelin4610.1GNRH1, CGA
4metrodin4610.0CGA, GNRH1
5antarelix46 3011.0CGA, GNRH1
6d-trp6-lhrh469.9GNRH1, CGA
7metoclopramide46 52 1211.6REN, GNRH1, CGA
817-hydroxyprogesterone46 2510.6REN, GNRH1, CGA
9ganirelix46 3010.6CGA, FSHB, GNRH1
10leuprolide acetate469.6CGA, GNRH1, FSHB
11buserelin46 30 1211.6GNRH1, FSHB, CGA
12clomiphene citrate469.6FSHB, GNRH1, CGA
13nafarelin46 62 30 1212.6GNRH1, CGA
14ornipressin469.6ALB, REN
15cyproteroneacetate469.5F5, GNRH1, REN
16metformin46 52 1211.4CGA, F5, GNRH1
1751-cr-edta469.4ALB, REN
18deoxyribonucleic acid469.4FSHB, FSHR, F5
19indapamide46 1210.4REN, ALB
20androstenedione46 2510.3GNRH1, FSHR, CGA, REN
21organon469.3CGA, FSHB
22gnrh469.2FSHR, CGA, GNRH1, FSHB
23naloxone46 30 52 1212.2CGA, ALB, GNRH1
24terlipressin46 1210.2REN, ALB
25spironolactone46 62 30 52 1213.2REN, GNRH1, ALB
26ribonucleic acid469.2CGA, FSHR, FSHB, GNRH1
27mifepristone46 30 62 1212.1CGA, VEGFA, GNRH1
28epinephrine46 25 1211.1CGA, F5, REN, GNRH1
29lisinopril46 52 25 1212.0ALB, REN, VEGFA
30perindopril46 52 1211.0ALB, VEGFA, REN
31halothane46 52 30 1212.0REN, ALB, F5
32progestin469.0CGA, F5, VEGFA, GNRH1
33candesartan46 52 30 1212.0VEGFA, ALB, REN
34kininogen469.0ALB, REN, F5
35prostacyclin468.9REN, F5, CGA, VEGFA
36tamoxifen46 52 30 1211.9CGA, VEGFA, GNRH1, F5
37thyroxine46 259.8ALB, REN, CGA, GNRH1
38pge2468.8VEGFA, FSHR, REN, CGA
39celecoxib46 62 30 52 25 1213.8VEGFA, ALB, REN
40actinomycin d468.8CGA, FSHB, GNRH1, VEGFA
41progesterone46 30 62 25 1212.7FSHB, FSHR, F5, GNRH1, CGA
42lactate468.5CGA, F5, ALB, GNRH1
43aspartate468.3CGA, GNRH1, ALB, F5
44alanine468.3FSHR, ALB, F5, CGA, GNRH1
45creatinine468.3F5, CGA, ALB, REN, GNRH1
46steroid468.3GNRH1, FSHB, FSHR, REN, F5, CGA
47heparin46 30 25 1211.1CGA, ALB, GNRH1, VEGFA, F5
48estrogen468.1GNRH1, VEGFA, CGA, F5, FSHB, FSHR
49estradiol46 25 1210.0CGA, GNRH1, FSHB, FSHR, REN, ALB
50testosterone46 62 25 1210.9GNRH1, FSHB, FSHR, ALB, F5, CGA

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

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17Gene Ontology
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Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.2VEGFA, ALB, F5
2extracellular spaceGO:0056157.6F5, ALB, REN, GNRH1, VEGFA
3extracellular regionGO:0055766.6CGA, F5, ALB, REN, FSHB, GNRH1

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1gonad developmentGO:00840610.0FSHR, CGA
2regulation of MAPK cascadeGO:0434089.9FSHR, REN
3Sertoli cell proliferationGO:0600119.9FSHR, FSHB
4regulation of osteoclast differentiationGO:0456709.9FSHB, FSHR
5female gamete generationGO:0072929.9FSHR, FSHB
6peptide hormone processingGO:0164869.8CGA, FSHB
7cell maturationGO:0484699.6REN, VEGFA
8male gonad developmentGO:0085849.6FSHR, REN
9kidney developmentGO:0018229.4REN, VEGFA
10female pregnancyGO:0075659.2FSHB, GNRH1
11positive regulation of cell migrationGO:0303359.2CGA, FSHB, VEGFA
12cellular protein metabolic processGO:0442679.1CGA, REN, FSHB
13positive regulation of cell proliferationGO:0082849.1CGA, FSHB, VEGFA
14platelet degranulationGO:0025768.8F5, ALB, VEGFA
15negative regulation of apoptotic processGO:0430668.7VEGFA, GNRH1, ALB
16platelet activationGO:0301688.7F5, ALB, VEGFA
17blood coagulationGO:0075968.6VEGFA, ALB, F5

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.1F5, ALB
2hormone activityGO:0051798.9CGA, FSHB, GNRH1

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

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Sources for Ovarian Hyperstimulation Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet