MCID: OVR029
MIFTS: 67

Ovarian Hyperstimulation Syndrome malady

Genetic diseases, Reproductive diseases, Rare diseases categories

Summaries for Ovarian Hyperstimulation Syndrome

About this section


Wikipedia:65 Ovarian hyperstimulation syndrome (OHSS) is a medical condition affecting the ovaries of some women who... more...

MalaCards based summary: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to polycystic ovary syndrome and adenoma, and has symptoms including autosomal dominant inheritance, abnormality of the genitourinary system and ascites. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Transcription CREM signaling in testis and Selected targets of GCR alpha. The drugs ganirelix and ganirelix acetate and the compounds altrenogest and pergonal have been mentioned in the context of this disorder. Affiliated tissues include endothelial, ovary and pituitary, and related mouse phenotypes are integument and tumorigenesis.

Description from OMIM:47 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

About this section
Sources:
47OMIM, 10Disease Ontology, 11diseasecard, 22GeneTests, 12DISEASES, 45Novoseek, 49Orphanet, 24GTR, 62UMLS, 35MeSH, 57SNOMED-CT, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Ovarian Hyperstimulation Syndrome, Aliases & Descriptions:

Name: Ovarian Hyperstimulation Syndrome 47 10 11 22 12 45 49 24 62
Secondary Meig's Syndrome 10
 
Ohss 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

OMIM47 608115
Disease Ontology10 DOID:5425
MeSH35 D016471
Orphanet49 64739
SNOMED-CT57 129635004
MESH via Orphanet36 D016471
ICD10 via Orphanet28 N98.1
UMLS via Orphanet63 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

About this section

Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Symptoms for Ovarian Hyperstimulation Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

608115

Clinical features from OMIM:

608115

HPO human phenotypes related to Ovarian Hyperstimulation Syndrome:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the genitourinary system HP:0000119
3 ascites HP:0001541
4 nausea HP:0002018
5 abdominal pain HP:0002027

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Ovarian Hyperstimulation Syndrome

About this section

Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome22 24 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

About this section

MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

33
Endothelial, Ovary, Pituitary, Liver, Thyroid, Breast, Bone, Lymph node, Kidney, Myeloid

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Ovarian Hyperstimulation Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6F5, FSHR, GNRH1, VEGFA
2MP:00020068.3VEGFA, GNRH1, FSHR, ALB
3MP:00053708.0F5, ALB, GNRH1, VEGFA
4MP:00053897.9VEGFA, GNRH1, FSHB, FSHR, REN, CGA
5MP:00053677.9VEGFA, GNRH1, REN, ALB
6MP:00036317.9VEGFA, GNRH1, FSHR, REN, F5, CGA
7MP:00053787.8VEGFA, GNRH1, FSHR, REN, F5, CGA
8MP:00053797.6VEGFA, GNRH1, FSHB, FSHR, ALB, CGA
9MP:00053766.6CGA, VEGFA, GNRH1, FSHB, FSHR, REN

Publications for Ovarian Hyperstimulation Syndrome

About this section

Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
Thrombosis following ovarian hyperstimulation syndrome. (25014487)
2014
2
Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman. (24971660)
2014
3
Ovarian Hyperstimulation Syndrome and Arterial Stroke. (25395409)
2014
4
GnRH agonist trigger and ovarian hyperstimulation syndrome: relook at 'freeze-all strategy'. (25042608)
2014
5
The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. (23295464)
2013
6
Cabergoline as treatment of ovarian hyperstimulation syndrome: a review. (23110560)
2013
7
Management of severe ovarian hyperstimulation syndrome with thawed plasma. (23869160)
2013
8
Spontaneous ovarian hyperstimulation syndrome. (23941020)
2013
9
Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. (23883350)
2013
10
Multiple transvaginal ascitic fluid aspirations improves the clinical and reproductive outcome in patients undergoing in vitro fertilisation treatment complicated by severe early ovarian hyperstimulation syndrome. (22519486)
2012
11
Spontaneous bacterial peritonitis complicating ovarian hyperstimulation syndrome-related ascites. (22189746)
2011
12
Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome. (21269615)
2011
13
Spontaneous ovarian hyperstimulation syndrome (OHSS): a rare but important differential diagnosis for abdominal distension in early pregnancy. (21534759)
2011
14
Heterotopic triplet pregnancy complicated with ovarian hyperstimulation syndrome following in vitro fertilization. (22649892)
2011
15
Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis. (21168129)
2011
16
A case of spontaneous ovarian hyperstimulation syndrome. (21353368)
2011
17
New insights of osmoregulatory system changes in ovarian hyperstimulation syndrome. (20850728)
2011
18
Ovarian hyperstimulation syndrome: pathophysiology and prevention. (20140640)
2010
19
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. (17721928)
2008
20
Ischaemic stroke with ovarian hyperstimulation syndrome. (18988418)
2008
21
Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome. (17356124)
2007
22
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
23
No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome. (16391898)
2006
24
Coasting for the prevention of ovarian hyperstimulation syndrome: much ado about nothing? (16500317)
2006
25
Spontaneous ovarian hyperstimulation syndrome in a normal singleton pregnancy. (17175480)
2006
26
Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). (16788381)
2006
27
Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester. (15618246)
2005
28
Prevention of ovarian hyperstimulation syndrome by early aspiration of small follicles in hyper-responsive patients with polycystic ovaries during assisted reproductive treatment cycles. (16369286)
2005
29
Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard? (15957998)
2005
30
Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. (14711532)
2004
31
Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome. (15212675)
2004
32
Severity of ovarian hyperstimulation syndrome: its relation to number of conceptuses. (15038508)
2004
33
Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. (15066453)
2004
34
Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study. (14585874)
2003
35
Clinical and laboratory evaluation of hospitalized patients with severe ovarian hyperstimulation syndrome. (12831592)
2003
36
Prediction of ovarian hyperstimulation syndrome. Challenging the estradiol mythos. (12660254)
2003
37
Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review. (12407029)
2002
38
Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception. (12477503)
2002
39
Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization. (12036082)
2002
40
Bilateral jugular venous thromboembolism and pulmonary emboli in a patient with severe ovarian hyperstimulation syndrome. (11721733)
2001
41
Ovarian hyperstimulation syndrome: an endocrinopathy? (11396659)
2001
42
Perforated duodenal ulcer associated with ovarian hyperstimulation syndrome: Case Report. (11139559)
2001
43
Does intravenous albumin prevent severe ovarian hyperstimulation syndrome? (9988419)
1999
44
Bilateral internal jugular venous thrombosis complicating severe ovarian hyperstimulation syndrome after prophylactic albumin administration. (9207607)
1997
45
does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome? (8816633)
1996
46
A severe case of ovarian hyperstimulation syndrome despite the prophylactic administration of intravenous albumin. (7545592)
1995
47
Use of GnRH analog for induction of the ovulatory surge of gonadotropins in patients at risk of the ovarian hyperstimulation syndrome. (7502696)
1995
48
Intravenous albumin and the prevention of severe ovarian hyperstimulation syndrome. (8567807)
1995
49
Does intravenous albumin prevent ovarian hyperstimulation syndrome? (8046036)
1994
50
Triggering ovulation with endogenous luteinizing hormone may prevent the ovarian hyperstimulation syndrome. (1918298)
1991

Variations for Ovarian Hyperstimulation Syndrome

About this section

UniProtKB/Swiss-Prot genetic disease variations for Ovarian Hyperstimulation Syndrome:

64
id Symbol AA change Variation ID SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Clinvar genetic disease variations for Ovarian Hyperstimulation Syndrome:

7
id Gene Variation Type Significance SNP ID Assembly Location
1FSHRNM_000145.3(FSHR): c.2039G> A (p.Ser680Asn)single nucleotide variantdrug responsers6166GRCh37Chr 2, 49189921: 49189921
2FSHRNM_000145.3(FSHR): c.1346C> T (p.Thr449Ile)single nucleotide variantPathogenicrs28928870GRCh37Chr 2, 49190614: 49190614
3FSHRNM_000145.3(FSHR): c.1699G> A (p.Asp567Asn)single nucleotide variantPathogenicrs28928871GRCh37Chr 2, 49190261: 49190261
4FSHRNM_000145.3(FSHR): c.1345A> G (p.Thr449Ala)single nucleotide variantPathogenicrs121909663GRCh37Chr 2, 49190615: 49190615
5FSHRNM_000145.3(FSHR): c.1634T> C (p.Ile545Thr)single nucleotide variantPathogenicrs121909664GRCh37Chr 2, 49190326: 49190326
6FSHRNM_000145.3(FSHR): c.383C> A (p.Ser128Tyr)single nucleotide variantPathogenicrs121909665GRCh37Chr 2, 49217768: 49217768

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

About this section

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

About this section

Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6FSHB, FSHR
29.6CGA, FSHB
39.2FSHB, FSHR, CGA
4
Show member pathways
9.2CGA, FSHR, FSHB
59.2CGA, FSHR, FSHB
69.2CGA, FSHR, FSHB
7
Show member pathways
9.2CGA, FSHB, GNRH1
8
Show member pathways
9.1FSHB, REN, CGA
9
Show member pathways
8.8CGA, FSHR, FSHB, GNRH1
108.8CGA, FSHR, FSHB, GNRH1
11
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5VEGFA, GNRH1, FSHB, CGA
12
Show member pathways
8.5VEGFA, ALB, F5
13
Show member pathways
8.5F5, ALB, VEGFA
14
Show member pathways
8.2VEGFA, GNRH1, FSHB, FSHR, CGA

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

About this section

Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1altrenogest4510.1CGA, GNRH1
2pergonal4510.1GNRH1, CGA
3deslorelin4510.1GNRH1, CGA
4metrodin4510.0CGA, GNRH1
5antarelix45 3011.0CGA, GNRH1
6d-trp6-lhrh459.9GNRH1, CGA
7metoclopramide45 51 1311.6REN, GNRH1, CGA
817-hydroxyprogesterone45 2610.6REN, GNRH1, CGA
9ganirelix45 3010.6CGA, FSHB, GNRH1
10leuprolide acetate459.6CGA, GNRH1, FSHB
11buserelin45 30 1311.6GNRH1, FSHB, CGA
12clomiphene citrate459.6FSHB, GNRH1, CGA
13nafarelin45 61 30 1312.6GNRH1, CGA
14ornipressin459.6ALB, REN
15cyproteroneacetate459.5F5, GNRH1, REN
16metformin45 51 1311.4CGA, F5, GNRH1
1751-cr-edta459.4ALB, REN
18deoxyribonucleic acid459.4FSHB, FSHR, F5
19indapamide45 1310.4REN, ALB
20androstenedione45 2610.3GNRH1, FSHR, CGA, REN
21organon459.3CGA, FSHB
22gnrh459.2FSHR, CGA, GNRH1, FSHB
23naloxone45 30 51 1312.2CGA, ALB, GNRH1
24terlipressin45 1310.2REN, ALB
25spironolactone45 61 30 51 1313.2REN, GNRH1, ALB
26ribonucleic acid459.2CGA, FSHR, FSHB, GNRH1
27mifepristone45 30 61 1312.1CGA, VEGFA, GNRH1
28epinephrine45 26 1311.1CGA, F5, REN, GNRH1
29lisinopril45 51 26 1312.0ALB, REN, VEGFA
30perindopril45 51 1311.0ALB, VEGFA, REN
31halothane45 51 30 1312.0REN, ALB, F5
32progestin459.0CGA, F5, VEGFA, GNRH1
33candesartan45 51 30 1312.0VEGFA, ALB, REN
34kininogen459.0ALB, REN, F5
35prostacyclin458.9REN, F5, CGA, VEGFA
36tamoxifen45 51 30 1311.9CGA, VEGFA, GNRH1, F5
37thyroxine45 269.8ALB, REN, CGA, GNRH1
38pge2458.8VEGFA, FSHR, REN, CGA
39celecoxib45 61 30 51 26 1313.8VEGFA, ALB, REN
40actinomycin d458.8CGA, FSHB, GNRH1, VEGFA
41progesterone45 30 61 26 1312.7FSHB, FSHR, F5, GNRH1, CGA
42lactate458.5CGA, F5, ALB, GNRH1
43aspartate458.3CGA, GNRH1, ALB, F5
44alanine458.3FSHR, ALB, F5, CGA, GNRH1
45creatinine458.3F5, CGA, ALB, REN, GNRH1
46steroid458.3GNRH1, FSHB, FSHR, REN, F5, CGA
47heparin45 30 26 1311.1CGA, ALB, GNRH1, VEGFA, F5
48estrogen458.1GNRH1, VEGFA, CGA, F5, FSHB, FSHR
49estradiol45 26 1310.0CGA, GNRH1, FSHB, FSHR, REN, ALB
50testosterone45 61 26 1310.9GNRH1, FSHB, FSHR, ALB, F5, CGA

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

About this section

Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310938.2VEGFA, ALB, F5
2extracellular spaceGO:00056157.6F5, ALB, REN, GNRH1, VEGFA
3extracellular regionGO:00055766.6CGA, F5, ALB, REN, FSHB, GNRH1

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1gonad developmentGO:000840610.0FSHR, CGA
2regulation of MAPK cascadeGO:00434089.9FSHR, REN
3Sertoli cell proliferationGO:00600119.9FSHR, FSHB
4regulation of osteoclast differentiationGO:00456709.9FSHB, FSHR
5female gamete generationGO:00072929.9FSHR, FSHB
6peptide hormone processingGO:00164869.8CGA, FSHB
7cell maturationGO:00484699.6REN, VEGFA
8male gonad developmentGO:00085849.6FSHR, REN
9kidney developmentGO:00018229.4REN, VEGFA
10female pregnancyGO:00075659.2FSHB, GNRH1
11positive regulation of cell migrationGO:00303359.2CGA, FSHB, VEGFA
12cellular protein metabolic processGO:00442679.1CGA, REN, FSHB
13positive regulation of cell proliferationGO:00082849.1CGA, FSHB, VEGFA
14platelet degranulationGO:00025768.8F5, ALB, VEGFA
15negative regulation of apoptotic processGO:00430668.7VEGFA, GNRH1, ALB
16platelet activationGO:00301688.7F5, ALB, VEGFA
17blood coagulationGO:00075968.6VEGFA, ALB, F5

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.1F5, ALB
2hormone activityGO:00051798.9CGA, FSHB, GNRH1

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Ovarian Hyperstimulation Syndrome

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet