OHSS
MCID: OVR029
MIFTS: 70

Ovarian Hyperstimulation Syndrome (OHSS) malady

Reproductive diseases category

Summaries for Ovarian Hyperstimulation Syndrome

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication,... more...

MalaCards: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to polycystic ovary syndrome and ovarian cyst. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Signaling by VEGF and Insulin Processing. The drugs ganirelix and ganirelix acetate and the compounds ganirelix and nafarelin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, ovary and pituitary, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Description from OMIM:46 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

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8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

ovarian hyperstimulation syndrome 8 9 20 22 46 10 44 48 60
secondary meig's syndrome 8
ohss 48


External Ids:

Disease Ontology8 DOID:5425
MeSH34 D016471
OMIM46 608115
MESH via Orphanet35 D016471
SNOMED-CT56 129635004
ICD10 via Orphanet26 N98.1
SNOMED-CT via Orphanet57 129635004
UMLS via Orphanet61 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Hyperstimulation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.0LHCGR, GNRH1, CGA, CYP19A1, FSHR, CGB5
2ovarian cyst30.8CYP19A1, CGB5, CGA, GNRH1
3peritonitis30.7ALB, AZU1
4pituitary adenoma30.7CGA, FSHB, GNRH1, FSHR, IL6R
5adenoma30.7FSHB, LHCGR, GNRH1, CGA, REN, IL6R
6hypothyroidism30.6GNRH1, CGA, FSHR
7ovarian disease30.6CGA, FSHR, GNRH1, AMH
8down syndrome30.6CGA, CGB5
9ovarian cancer30.5FSHR, KDR, CYP19A1, CDH5, CGB5, GNRH1
10stroke, ischemic30.4ALB, REN, AMH, F5
11infertility30.4CGA, BMP15, GNRH1, AMH, CYP19A1, FSHR
12breast cancer30.4VEGFA, CYP19A1, IL6R, GNRH1, KDR
13thyroiditis30.2CGA
14lupus erythematosus30.2F5
15hyperprolactinemia30.2GNRH1, CGB5, CGA
16hypogonadism30.2FSHB, LHCGR, GNRH1, CGA, CGB5, CYP19A1
17antiphospholipid syndrome30.2F5
18thrombophilia10.5
19pulmonary edema10.4
20cerebritis10.4
21duodenal ulcer10.3
22arts syndrome10.3
23duodenitis10.3
24adult syndrome10.3
25vaginitis10.3
26central retinal artery occlusion10.1
27anuria10.1
28cystic fibrosis10.1
29von willebrand's disease10.1
30adult respiratory distress syndrome10.1
31systemic lupus erythematosus10.1
32good syndrome10.1
33appendicitis10.1
34pregnancy adenoma10.1
35n syndrome10.1
36antithrombin iii deficiency10.1
37hepatitis a10.1
38amyloidosis10.1
39aphasia10.1
40cervicitis10.1
41compartment syndrome10.1
42hepatitis10.1
43influenza10.1
44intracranial thrombosis10.1
45lactic acidosis10.1
46migraine10.1
47pneumonia10.1
48respiratory failure10.1
49retinal artery occlusion10.1
50retinitis10.1

Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Clinical Features for Ovarian Hyperstimulation Syndrome

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46OMIM
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Clinical features from OMIM:

608115

Clinical synopsis from OMIM:

608115

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Ovarian Hyperstimulation Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome20 22 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

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32MalaCards
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MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

32
Endothelial, Ovary, Pituitary, Liver, Breast, Thyroid, Kidney, Myeloid, Lymph node, Bone

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Hyperstimulation Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2LHCGR, AMH, BMP15, IL6R, GPR89B, FSHR
2MP:000537010.0GNRH1, F5, VEGFA, CYP19A1, IL6R, KDR
3MP:000287310.0GNRH1, TBX4, VEGFA, CDH5, CYP19A1, REN
4MP:000538510.0KLKB1, TBX4, CDH5, CYP19A1, REN, FSHR
5MP:00053899.9LHCGR, AMH, GNRH1, BMP15, CGA, VEGFA
6MP:00036319.9F5, CGA, TBX4, VEGFA, CYP19A1, REN
7MP:00053879.9LHCGR, GNRH1, VEGFA, CDH5, CYP19A1, REN
8MP:00107719.9GNRH1, VEGFA, GPR89B, FSHR, KDR
9MP:00053789.9VEGFA, CGA, F5, GNRH1, LHCGR, CDH5
10MP:00053769.7ALB, KLKB1, LHCGR, AMH, GNRH1, F5

Publications for Ovarian Hyperstimulation Syndrome

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50PubMed
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Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Cabergoline as treatment of ovarian hyperstimulation syndrome: a review. (23110560)
2013
2
Management of ovarian hyperstimulation syndrome guidelines. Produced on behalf of the BFS Policy and Practice Committee. (23705631)
2013
3
Assessment of cells in the ascitic fluid of women with ovarian hyperstimulation syndrome: the clinical implications for subsequent ovarian malignancy. (24028152)
2013
4
Ovarian hyperstimulation syndrome. (23944686)
2013
5
Ovarian hyperstimulation syndrome is correlated with a reduction of soluble VEGF receptor protein level and a higher amount of VEGF-A. (22016416)
2012
6
New insights of osmoregulatory system changes in ovarian hyperstimulation syndrome. (20850728)
2011
7
Ovarian hyperstimulation syndrome in a spontaneous pregnancy with invasive mole: report of a case. (22355432)
2011
8
Prevention of ovarian hyperstimulation syndrome. (21530962)
2011
9
Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome. (20444920)
2010
10
New insights in mechanisms for development of ovarian hyperstimulation syndrome. (20977119)
2010
11
The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial. (20139430)
2010
12
Pharmacotherapy of ovarian hyperstimulation syndrome. (20854183)
2010
13
A unique human chorionic gonadotropin antagonist suppresses ovarian hyperstimulation syndrome in rats. (19443574)
2009
14
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. (19325005)
2009
15
Miscarriage and clinical correlates of leukocyte count in patients with ovarian hyperstimulation syndrome. (19835500)
2009
16
Possible familial gestational spontaneous ovarian hyperstimulation syndrome due to mutation of FSH receptors (FGSOHS). (19391457)
2009
17
Isolated bilateral pleural effusion as the sole manifestation of late onset ovarian hyperstimulation syndrome. (19881155)
2009
18
Ischaemic stroke with ovarian hyperstimulation syndrome. (18988418)
2008
19
The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. (17462639)
2008
20
An unusual cause of tachycardia, hypotension, and intraabdominal free fluid: ovarian hyperstimulation syndrome. (18606347)
2008
21
Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome. (18216038)
2008
22
Ovarian hyperstimulation syndrome. (17692773)
2007
23
Severe ovarian hyperstimulation syndrome in a twin pregnancy after intracytoplasmic sperm injection. (17688637)
2007
24
Embryo freezing for preventing ovarian hyperstimulation syndrome. (17636707)
2007
25
Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome. (17074323)
2007
26
Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. (16278261)
2006
27
Prevention and management of ovarian hyperstimulation syndrome. (17308149)
2006
28
Use of recombinant human activated protein C in treatment of severe sepsis in a pregnant patient with fully symptomatic ovarian hyperstimulation syndrome. (15917724)
2005
29
Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. (14711532)
2004
30
Severity of ovarian hyperstimulation syndrome: its relation to number of conceptuses. (15038508)
2004
31
Isolated unilateral pleural effusion as the only manifestation of the ovarian hyperstimulation syndrome. (14710293)
2003
32
The Predictive Role of Vascular Endothelial Growth Factor and Estradiol in Infertile Patients with Ovarian Hyperstimulation Syndrome]. (12910723)
2003
33
New concepts in the understanding of the ovarian hyperstimulation syndrome. (12858114)
2003
34
High interleukin 2 receptor levels in the pleural effusion of a patient with pulmonary manifestations of ovarian hyperstimulation syndrome. (12455193)
2002
35
Massive unilateral hydrothorax as the only clinical manifestation of ovarian hyperstimulation syndrome. (12814049)
2002
36
Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program. (11447736)
2001
37
Elevated interleukin-10 and sex steroid levels in peritoneal fluid of patients with ovarian hyperstimulation syndrome. (11788177)
2001
38
Occlusion of the ulnar artery in a patient with severe ovarian hyperstimulation syndrome. (11311778)
2001
39
Ovarian hyperstimulation syndrome complicating a spontaneous singleton pregnancy: a case report. (11285979)
2001
40
Use of a single bolus of GnRH agonist triptorelin to trigger ovulation after GnRH antagonist ganirelix treatment in women undergoing ovarian stimulation for assisted reproduction, with special reference to the prevention of ovarian hyperstimulation syndrome: preliminary report: short communication. (10966996)
2000
41
Does intravenous albumin prevent severe ovarian hyperstimulation syndrome? (9988419)
1999
42
A case of ovarian hyperstimulation syndrome in which antithrombin III deficiency occurred because of its loss into ascites. (10231046)
1999
43
Role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome. (9886504)
1998
44
High dose gonadotrophin-releasing hormone antagonist (ganirelix) may prevent ovarian hyperstimulation syndrome caused by ovarian stimulation for in-vitro fertilization. (9572414)
1998
45
Effects of angiotensin converting enzyme inhibitor cilazapril and angiotensin II antagonist saralasin in ovarian hyperstimulation syndrome in the rabbit. (9272418)
1997
46
High renin and prorenin in plasma and pleural exudate of a patient with the ovarian hyperstimulation syndrome. (9499695)
1997
47
Comparison of gonadotrophin-releasing hormone analogues and human chorionic gonadotrophin for the induction of ovulation and prevention of ovarian hyperstimulation syndrome: a case-control study. (8671474)
1996
48
Early timed follicular aspiration prevents severe ovarian hyperstimulation syndrome. (8777340)
1996
49
Ovarian hyperstimulation syndrome: pre-ovulatory serum concentrations of interleukin-6, interleukin-1 receptor antagonist and tumour necrosis factor-alpha cannot predict its occurrence. (8671470)
1996
50
Total ovarian volume before human chorionic gonadotrophin administration for ovulation induction may predict the hyperstimulation syndrome. (8822446)
1995

Genetic Variations for Ovarian Hyperstimulation Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Ovarian Hyperstimulation Syndrome:

62
id Symbol AA change Variation ID SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

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53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4KDR, VEGFA
2
Hide members
10.3FSHB, REN, CGA
3
Hide members
10.3F5, VEGFA, ALB
410.3KDR, REN, CDH5
510.3FSHR, CYP19A1, LHCGR
6
Hide members
10.3VEGFA, CDH5, KDR
7
Hide members
10.3VEGFA, CDH5, KDR
810.3KLKB1, VEGFA, KDR
910.2FSHB, FSHR, CYP19A1, CGA
10
Hide members
10.2FSHB, FSHR, CGA, LHCGR
11
Hide members
10.2FSHB, FSHR, CGA, LHCGR
12
Development Endothelin-1/EDNRA signaling
Hide members
10.2GNRH1, CGA, VEGFA, FSHB, KDR
13
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
14
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
15
Hide members
10.2GNRH1, CGA, CDH5, FSHB, KDR
1610.1LHCGR, BMP15, CGA, CYP19A1, FSHR, FSHB

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1ganirelix44 2811.7FSHB, GNRH1, CGA
2nafarelin44 59 28 1113.6GNRH1, CYP19A1, CGA
3pge24410.6FSHR, REN, VEGFA, LHCGR
4organon4410.6CGB5, CGA, FSHB
5estradiol benzoate4410.6CGB5, CGA, GNRH1, CYP19A1
6goserelin44 28 1112.6GNRH1, LHCGR, CYP19A1, CGA
7heparin44 28 11 2413.6GNRH1, AZU1, CGA, VEGFA
8cyproteroneacetate4410.6REN, GNRH1, F5, CYP19A1
9cetrorelix44 28 1112.6CGB5, CGA, GNRH1, LHCGR
10flutamide44 59 1112.6CYP19A1, CGA, GNRH1, LHCGR
11clomiphene citrate4410.6CYP19A1, FSHB, CGB5, CGA, GNRH1
1217-hydroxyprogesterone44 2411.6CGB5, REN, CGA, CYP19A1, GNRH1
13leuprolide44 59 28 1113.6CGA, CGB5, GNRH1
14celecoxib44 59 28 49 11 2415.6KDR, CYP19A1, REN, VEGFA, ALB
15naloxone44 49 28 1113.5CGB5, GNRH1, ALB, CGA
16diethylstilbestrol44 28 1112.5CGB5, CGA, GNRH1, CYP19A1
17androstenedione44 2411.5GNRH1, CGA, FSHR, CGB5, REN, CYP19A1
18gnrh4410.5CGA, GNRH1, FSHR, FSHB, LHCGR, CYP19A1
19leuprolide acetate4410.5FSHB, CYP19A1, CGB5, LHCGR, CGA, GNRH1
20buserelin44 28 1112.5LHCGR, GNRH1, CGA, CGB5, CYP19A1, FSHB
21dehydroepiandrosterone sulfate4410.5CGA, GNRH1, CYP19A1, CGB5
22mifepristone44 59 28 1113.5GNRH1, CGA, AMH, CGB5, VEGFA, CYP19A1
23hydrocortisone44 2 59 1113.5F5, REN, CYP19A1, KDR, CDH5
243beta-hydroxysteroid4410.5LHCGR, CGB5, CGA, CYP19A1
25indomethacin44 59 28 1113.5CGA, CGB5, KDR, REN, ALB, CYP19A1
26isoproterenol44 1111.4CGB5, CDH5, GNRH1, LHCGR
27metformin44 49 1112.4CGA, F5, GNRH1, CYP19A1
28kininogen4410.4KLKB1, ALB, F5, REN
29cyclophosphamide44 49 1112.4CGB5, CYP19A1, CGA, F5, KDR
30prostacyclin4410.4CGA, KDR, REN, VEGFA, F5
31lisinopril44 11 2412.4ALB, REN, VEGFA
32folate4410.4CGB5, KDR, CGA, F5, ALB
33creatinine4410.4REN, CGB5, F5, CGA, IL6R, ALB
34progestin4410.4GNRH1, F5, CGA, CYP19A1, KDR, CGB5
35ribonucleic acid4410.4FSHB, LHCGR, GNRH1, CGA, CGB5, CDH5
36tamoxifen44 49 28 1113.4AMH, GNRH1, F5, CGA, CGB5, KDR
37prostaglandin f2alpha4410.4LHCGR, GNRH1, CGB5, CGA
38fibrinogen4410.4CDH5, KLKB1, ALB, IL6R, CGB5, F5
39acth4410.3FSHB, REN, CGB5, GNRH1, LHCGR
40steroid4410.3IL6R, LHCGR, GNRH1, F5, CGB5, CYP19A1
41vegf4410.3CGA, AZU1, KDR, F5, REN, CDH5
42thalidomide44 49 59 1113.2KDR, IL6R, VEGFA, AMH
43testosterone44 59 11 2413.2GNRH1, FSHB, LHCGR, ALB, AMH, FSHR
44progesterone44 59 28 11 2414.2GNRH1, AMH, CGB5, CYP19A1, IL6R, F5
45dexamethasone44 49 28 1113.2GNRH1, VEGFA, KDR, CGB5, REN, IL6R
46arginine4410.2KDR, LHCGR, GNRH1, F5, CGA, CGB5
47estradiol44 11 2412.2REN, CGA, LHCGR, CGB5, CDH5, CYP19A1
48methotrexate44 49 1112.1IL6R, CGA, ALB, CYP19A1, CGB5
49gefitinib44 49 1112.1VEGFA, KDR, CYP19A1, ALB
50lactate449.8ALB, F5, GNRH1, CGA, CGB5, KDR

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

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16Gene Ontology
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Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3ALB, VEGFA, F5
2extracellular regionGO:0055769.6ALB, KLKB1, AZU1, AMH, GNRH1, F5
3extracellular spaceGO:0056159.6KLKB1, AMH, GNRH1, BMP15, F5, VEGFA

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1follicle-stimulating hormone signaling pathwayGO:04269910.6FSHB, FSHR
2female gamete generationGO:00729210.6BMP15, FSHR, FSHB
3cell maturationGO:04846910.5KDR, REN, VEGFA
4positive regulation of cell migrationGO:03033510.5CGA, VEGFA, FSHB, KDR
5positive regulation of positive chemotaxisGO:05092710.5VEGFA, KDR
6surfactant homeostasisGO:04312910.4VEGFA, KDR
7ovarian follicle developmentGO:00154110.4KDR, FSHB, VEGFA, BMP15, LHCGR
8positive regulation of cell proliferationGO:00828410.4CGA, VEGFA, IL6R, FSHB, KDR
9cell migration involved in sprouting angiogenesisGO:00204210.4KDR, VEGFA
10negative regulation of apoptotic processGO:04306610.3ALB, KDR, VEGFA, GNRH1, AZU1
11male gonad developmentGO:00858410.3FSHR, REN, LHCGR
12platelet degranulationGO:00257610.2F5, VEGFA, ALB
13positive regulation of focal adhesion assemblyGO:05189410.1KDR, VEGFA

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:01564310.3ALB, AZU1
2hormone activityGO:0051799.9FSHB, CGA, GNRH1, AMH

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

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Sources for Ovarian Hyperstimulation Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet