OHSS
MCID: OVR029
MIFTS: 70

Ovarian Hyperstimulation Syndrome (OHSS) malady

Reproductive diseases category

Summaries for Ovarian Hyperstimulation Syndrome

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication,... more...

MalaCards: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to polycystic ovary syndrome and ovarian cyst. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Signaling by VEGF and Insulin Processing. The drugs ganirelix and ganirelix acetate and the compounds ganirelix and nafarelin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, ovary and pituitary, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Description from OMIM:46 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

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8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

ovarian hyperstimulation syndrome 8 9 20 22 46 10 44 48 60
secondary meig's syndrome 8
ohss 48


External Ids:

Disease Ontology8 DOID:5425
MeSH34 D016471
OMIM46 608115
MESH via Orphanet35 D016471
SNOMED-CT56 129635004
ICD10 via Orphanet26 N98.1
SNOMED-CT via Orphanet57 129635004
UMLS via Orphanet61 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Ovarian Hyperstimulation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.0LHCGR, GNRH1, CGA, CYP19A1, FSHR, CGB5
2ovarian cyst30.8CYP19A1, CGB5, CGA, GNRH1
3peritonitis30.7ALB, AZU1
4pituitary adenoma30.7CGA, FSHB, GNRH1, FSHR, IL6R
5adenoma30.7FSHB, LHCGR, GNRH1, CGA, REN, IL6R
6hypothyroidism30.6GNRH1, CGA, FSHR
7ovarian disease30.6CGA, FSHR, GNRH1, AMH
8down syndrome30.6CGA, CGB5
9ovarian cancer30.5FSHR, KDR, CYP19A1, CDH5, CGB5, GNRH1
10stroke, ischemic30.4ALB, REN, AMH, F5
11infertility30.4CGA, BMP15, GNRH1, AMH, CYP19A1, FSHR
12breast cancer30.4VEGFA, CYP19A1, IL6R, GNRH1, KDR
13thyroiditis30.2CGA
14lupus erythematosus30.2F5
15hyperprolactinemia30.2GNRH1, CGB5, CGA
16hypogonadism30.2FSHB, LHCGR, GNRH1, CGA, CGB5, CYP19A1
17antiphospholipid syndrome30.2F5
18thrombophilia10.5
19pulmonary edema10.4
20cerebritis10.4
21duodenal ulcer10.3
22arts syndrome10.3
23duodenitis10.3
24adult syndrome10.3
25vaginitis10.3
26central retinal artery occlusion10.1
27anuria10.1
28cystic fibrosis10.1
29von willebrand's disease10.1
30adult respiratory distress syndrome10.1
31systemic lupus erythematosus10.1
32good syndrome10.1
33appendicitis10.1
34pregnancy adenoma10.1
35n syndrome10.1
36antithrombin iii deficiency10.1
37hepatitis a10.1
38amyloidosis10.1
39aphasia10.1
40cervicitis10.1
41compartment syndrome10.1
42hepatitis10.1
43influenza10.1
44intracranial thrombosis10.1
45lactic acidosis10.1
46migraine10.1
47pneumonia10.1
48respiratory failure10.1
49retinal artery occlusion10.1
50retinitis10.1

Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Clinical Features for Ovarian Hyperstimulation Syndrome

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46OMIM
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Clinical features from OMIM:

608115

Clinical synopsis from OMIM:

608115

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Ovarian Hyperstimulation Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome20 22 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

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32MalaCards
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MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

32
Endothelial, Ovary, Pituitary, Liver, Breast, Thyroid, Kidney, Myeloid, Lymph node, Bone

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ovarian Hyperstimulation Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2BMP15, IL6R, GPR89B, FSHR, AMH, LHCGR
2MP:000537010.0VEGFA, GNRH1, F5, CYP19A1, IL6R, KDR
3MP:000287310.0TBX4, VEGFA, CDH5, CYP19A1, REN, KDR
4MP:000538510.0KLKB1, FSHR, REN, TBX4, CDH5, CYP19A1
5MP:00053899.9LHCGR, GPR89B, FSHR, FSHB, REN, CYP19A1
6MP:00036319.9GNRH1, F5, KDR, CYP19A1, REN, CGA
7MP:00053879.9GNRH1, VEGFA, CDH5, CYP19A1, IL6R, REN
8MP:00107719.9FSHR, GNRH1, VEGFA, GPR89B, KDR
9MP:00053789.9CDH5, REN, IL6R, GPR89B, FSHR, KDR
10MP:00053769.7TBX4, AMH, KLKB1, LHCGR, GNRH1, FSHB

Publications for Ovarian Hyperstimulation Syndrome

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50PubMed
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Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. (23883350)
2013
2
A potential novel strategy, inhibition of vasopressin-induced VEGF secretion by relcovaptan, for decreasing the incidence of ovarian hyperstimulation syndrome in the hyperstimulated rat model. (24405730)
2013
3
Induction of final follicle maturation with a gonadotropin-releasing hormone agonist in women at risk of ovarian hyperstimulation syndrome undergoing gonadotropin stimulation and intrauterine insemination: proof-of-concept study. (23444737)
2012
4
Comparative incidence of ovarian hyperstimulation syndrome following ovarian stimulation with corifollitropin alfa or recombinant FSH. (22386594)
2012
5
Emergency ultrasound diagnosis of ovarian hyperstimulation syndrome: case report. (22525699)
2012
6
Spontaneous bacterial peritonitis complicating ovarian hyperstimulation syndrome-related ascites. (22189746)
2011
7
Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome. (21328256)
2011
8
Physiology and pathology of ovarian hyperstimulation syndrome. (21082502)
2010
9
How to avoid ovarian hyperstimulation syndrome: a new indication for dopamine agonists. (19406035)
2009
10
Ovarian hyperstimulation syndrome in newborns--a case presentation and literature review. (19039238)
2009
11
Ovarian hyperstimulation syndrome in a spontaneous pregnancy with a complete hydatidiform mole. (19368914)
2009
12
Life-threatening thromboembolic events and ovarian hyperstimulation syndrome. (19891240)
2009
13
Molecular mechanisms of ovarian hyperstimulation syndrome: paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability. (19168871)
2009
14
Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women. (18321487)
2009
15
Ovarian hyperstimulation syndrome and complications of ART. (19632900)
2009
16
Coasting vs. cryopreservation of all embryos for prevention of ovarian hyperstimulation syndrome in in vitro fertilization. (18163999)
2008
17
GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy? (18256922)
2008
18
Dual renin-angiotensin blockage and total embryo cryopreservation is not a risk-free strategy in patients at high risk for ovarian hyperstimulation syndrome. (18001715)
2008
19
Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome. (18385260)
2008
20
Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome. (18159088)
2008
21
Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome. (18171700)
2008
22
Odds of ovarian hyperstimulation syndrome (OHSS) - time for reassessment. (17786650)
2007
23
Ovarian hyperstimulation syndrome in gonadotropin-treated laboratory South African clawed frogs (Xenopus laevis). (17487957)
2007
24
Update on ovarian hyperstimulation syndrome: part 2--clinical signs and treatment. (18320864)
2007
25
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
26
Genetic predictors of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. (17082800)
2006
27
Ovarian hyperstimulation syndrome. (17055817)
2006
28
Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester. (15618246)
2005
29
Follicular aspiration during the selection phase prevents severe ovarian hyperstimulation in patients with polycystic ovary syndrome who are undergoing in vitro fertilization. (16154042)
2005
30
Laparoscopic unwinding and cyst aspiration of an ovarian torsion in spontaneous ovarian hyperstimulation syndrome associated with a singleton pregnancy. (15191459)
2004
31
Ovarian hyperstimulation syndrome. (15363699)
2004
32
Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS). (12638783)
2003
33
A chorionic gonadotropin-sensitive mutation in the follicle- stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. (12930927)
2003
34
Prevention of severe ovarian hyperstimulation syndrome (OHSS) in IVF patients by steroidal ovarian suppression--a prospective randomized study. (12960445)
2003
35
Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization. (12036082)
2002
36
A qualitative systematic review of coasting, a procedure to avoid ovarian hyperstimulation syndrome in IVF patients. (12078839)
2002
37
Vascular endothelial growth factor, polycystic ovary syndrome, and ovarian hyperstimulation syndrome. (12477506)
2002
38
Variations in serum vascular endothelial growth factor binding profiles and the development of ovarian hyperstimulation syndrome. (12137864)
2002
39
Function of vascular endothelial growth factor in ovarian hyperstimulation syndrome]. (11930687)
2001
40
An autopsy case of ovarian hyperstimulation syndrome with massive pulmonary edema and pleural effusion. (10886738)
2000
41
Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries. (9797093)
1998
42
Integral treatment of severe ovarian hyperstimulation syndrome by means of autotransfusion of ascitic fluid and intravenous infusion of albumin]. (9745198)
1998
43
Ovarian origin of plasma and peritoneal fluid prorenin in early pregnancy and in patients with ovarian hyperstimulation syndrome. (9024237)
1997
44
Severe ovarian hyperstimulation syndrome and combined intrauterine and tubal pregnancy after in-vitro fertilization and embryo transfer. (8671159)
1996
45
Use of GnRH analog for induction of the ovulatory surge of gonadotropins in patients at risk of the ovarian hyperstimulation syndrome. (7502696)
1995
46
Intravenous albumin does not prevent the development of severe ovarian hyperstimulation syndrome in an in-vitro fertilization programme. (7650125)
1995
47
Ovarian cyst aspiration: a therapeutic approach to ovarian hyperstimulation syndrome. (1426334)
1992
48
Steroidogenesis of cultured granulosa cells in women at risk for ovarian hyperstimulation syndrome. (1459265)
1992
49
Liver abnormality in ovarian hyperstimulation syndrome. (1982004)
1990
50
Early unwinding of torsion of an ovarian cyst as result of hyperstimulation syndrome. (6411500)
1983

Genetic Variations for Ovarian Hyperstimulation Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Ovarian Hyperstimulation Syndrome:

62
id Symbol AA change Variation ID SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

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53Reactome, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4KDR, VEGFA
2
Hide members
10.3FSHB, REN, CGA
3
Hide members
10.3F5, VEGFA, ALB
410.3KDR, REN, CDH5
510.3FSHR, CYP19A1, LHCGR
6
Hide members
10.3VEGFA, CDH5, KDR
7
Hide members
10.3VEGFA, CDH5, KDR
810.3KLKB1, VEGFA, KDR
910.2FSHB, FSHR, CYP19A1, CGA
10
Hide members
10.2FSHB, FSHR, CGA, LHCGR
11
Hide members
10.2FSHB, FSHR, CGA, LHCGR
12
Development Endothelin-1/EDNRA signaling
Hide members
10.2GNRH1, CGA, VEGFA, FSHB, KDR
13
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
14
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
15
Hide members
10.2GNRH1, CGA, CDH5, FSHB, KDR
1610.1LHCGR, BMP15, CGA, CYP19A1, FSHR, FSHB

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1ganirelix44 2811.7FSHB, GNRH1, CGA
2nafarelin44 59 28 1113.6GNRH1, CYP19A1, CGA
3pge24410.6FSHR, REN, VEGFA, LHCGR
4organon4410.6CGB5, CGA, FSHB
5estradiol benzoate4410.6CGB5, CGA, GNRH1, CYP19A1
6goserelin44 28 1112.6GNRH1, LHCGR, CYP19A1, CGA
7heparin44 28 11 2413.6GNRH1, AZU1, CGA, VEGFA
8cyproteroneacetate4410.6REN, GNRH1, F5, CYP19A1
9cetrorelix44 28 1112.6CGB5, CGA, GNRH1, LHCGR
10flutamide44 59 1112.6CYP19A1, CGA, GNRH1, LHCGR
11clomiphene citrate4410.6CYP19A1, FSHB, CGB5, CGA, GNRH1
1217-hydroxyprogesterone44 2411.6CGB5, REN, CGA, CYP19A1, GNRH1
13leuprolide44 59 28 1113.6CGA, CGB5, GNRH1
14celecoxib44 59 28 49 11 2415.6KDR, CYP19A1, REN, VEGFA, ALB
15naloxone44 49 28 1113.5CGB5, GNRH1, ALB, CGA
16diethylstilbestrol44 28 1112.5CGB5, CGA, GNRH1, CYP19A1
17androstenedione44 2411.5GNRH1, CGA, FSHR, CGB5, REN, CYP19A1
18gnrh4410.5CGA, GNRH1, FSHR, FSHB, LHCGR, CYP19A1
19leuprolide acetate4410.5FSHB, CYP19A1, CGB5, LHCGR, CGA, GNRH1
20buserelin44 28 1112.5LHCGR, GNRH1, CGA, CGB5, CYP19A1, FSHB
21dehydroepiandrosterone sulfate4410.5CGA, GNRH1, CYP19A1, CGB5
22mifepristone44 59 28 1113.5GNRH1, CGA, AMH, CGB5, VEGFA, CYP19A1
23hydrocortisone44 2 59 1113.5F5, REN, CYP19A1, KDR, CDH5
243beta-hydroxysteroid4410.5LHCGR, CGB5, CGA, CYP19A1
25indomethacin44 59 28 1113.5CGA, CGB5, KDR, REN, ALB, CYP19A1
26isoproterenol44 1111.4CGB5, CDH5, GNRH1, LHCGR
27metformin44 49 1112.4CGA, F5, GNRH1, CYP19A1
28kininogen4410.4KLKB1, ALB, F5, REN
29cyclophosphamide44 49 1112.4CGB5, CYP19A1, CGA, F5, KDR
30prostacyclin4410.4CGA, KDR, REN, VEGFA, F5
31lisinopril44 11 2412.4ALB, REN, VEGFA
32folate4410.4CGB5, KDR, CGA, F5, ALB
33creatinine4410.4REN, CGB5, F5, CGA, IL6R, ALB
34progestin4410.4GNRH1, F5, CGA, CYP19A1, KDR, CGB5
35ribonucleic acid4410.4FSHB, LHCGR, GNRH1, CGA, CGB5, CDH5
36tamoxifen44 49 28 1113.4AMH, GNRH1, F5, CGA, CGB5, KDR
37prostaglandin f2alpha4410.4LHCGR, GNRH1, CGB5, CGA
38fibrinogen4410.4CDH5, KLKB1, ALB, IL6R, CGB5, F5
39acth4410.3FSHB, REN, CGB5, GNRH1, LHCGR
40steroid4410.3IL6R, LHCGR, GNRH1, F5, CGB5, CYP19A1
41vegf4410.3CGA, AZU1, KDR, F5, REN, CDH5
42thalidomide44 49 59 1113.2KDR, IL6R, VEGFA, AMH
43testosterone44 59 11 2413.2GNRH1, FSHB, LHCGR, ALB, AMH, FSHR
44progesterone44 59 28 11 2414.2GNRH1, AMH, CGB5, CYP19A1, IL6R, F5
45dexamethasone44 49 28 1113.2GNRH1, VEGFA, KDR, CGB5, REN, IL6R
46arginine4410.2KDR, LHCGR, GNRH1, F5, CGA, CGB5
47estradiol44 11 2412.2REN, CGA, LHCGR, CGB5, CDH5, CYP19A1
48methotrexate44 49 1112.1IL6R, CGA, ALB, CYP19A1, CGB5
49gefitinib44 49 1112.1VEGFA, KDR, CYP19A1, ALB
50lactate449.8ALB, F5, GNRH1, CGA, CGB5, KDR

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

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16Gene Ontology
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Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3ALB, VEGFA, F5
2extracellular regionGO:0055769.6ALB, KLKB1, AZU1, AMH, GNRH1, F5
3extracellular spaceGO:0056159.6KLKB1, AMH, GNRH1, BMP15, F5, VEGFA

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1follicle-stimulating hormone signaling pathwayGO:04269910.6FSHB, FSHR
2female gamete generationGO:00729210.6BMP15, FSHR, FSHB
3cell maturationGO:04846910.5KDR, REN, VEGFA
4positive regulation of cell migrationGO:03033510.5CGA, VEGFA, FSHB, KDR
5positive regulation of positive chemotaxisGO:05092710.5VEGFA, KDR
6surfactant homeostasisGO:04312910.4VEGFA, KDR
7ovarian follicle developmentGO:00154110.4KDR, FSHB, VEGFA, BMP15, LHCGR
8positive regulation of cell proliferationGO:00828410.4CGA, VEGFA, IL6R, FSHB, KDR
9cell migration involved in sprouting angiogenesisGO:00204210.4KDR, VEGFA
10negative regulation of apoptotic processGO:04306610.3ALB, KDR, VEGFA, GNRH1, AZU1
11male gonad developmentGO:00858410.3FSHR, REN, LHCGR
12platelet degranulationGO:00257610.2F5, VEGFA, ALB
13positive regulation of focal adhesion assemblyGO:05189410.1KDR, VEGFA

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:01564310.3ALB, AZU1
2hormone activityGO:0051799.9FSHB, CGA, GNRH1, AMH

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

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Sources for Ovarian Hyperstimulation Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet