OHSS
MCID: OVR029
MIFTS: 61

Ovarian Hyperstimulation Syndrome (OHSS) malady

Reproductive category

Summaries for Ovarian Hyperstimulation Syndrome

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication,... more...

MalaCards: Ovarian Hyperstimulation Syndrome, also known as secondary meig's syndrome, is related to polycystic ovary syndrome and adenoma. An important gene associated with Ovarian Hyperstimulation Syndrome is FSHR (follicle stimulating hormone receptor), and among its related pathways are Signaling by VEGF and Insulin Processing. The drugs ganirelix and ganirelix acetate and the compounds ganirelix and nafarelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and kidney, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Description from OMIM:47 608115

Aliases & Classifications for Ovarian Hyperstimulation Syndrome

Sources:
8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

ovarian hyperstimulation syndrome 8 9 20 22 47 10 45 49 61
secondary meig's syndrome 8
ohss 49


External Ids:

Disease Ontology8 DOID:5425
MeSH35 D016471
OMIM47 608115
MESH via Orphanet36 D016471
SNOMED-CT57 129635004
ICD10 via Orphanet26 N98.1
SNOMED-CT via Orphanet58 129635004
UMLS via Orphanet62 C0085083

Related Diseases for Ovarian Hyperstimulation Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Ovarian Hyperstimulation Syndrome:



Diseases related to ovarian hyperstimulation syndrome

Clinical Features for Ovarian Hyperstimulation Syndrome

Sources:
47OMIM
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Clinical features from OMIM:

608115

Clinical synopsis from OMIM:

608115

Drugs & Therapeutics for Ovarian Hyperstimulation Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Drug clinical trials:

Search ClinicalTrials for Ovarian Hyperstimulation Syndrome

Search NIH Clinical Center for Ovarian Hyperstimulation Syndrome

Search CenterWatch for Ovarian Hyperstimulation Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Ovarian Hyperstimulation Syndrome

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Ovarian Hyperstimulation Syndrome:

id Genetic test Affiliating Genes
1 Ovarian Hyperstimulation Syndrome20 22 FSHR

Anatomical Context for Ovarian Hyperstimulation Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Ovarian Hyperstimulation Syndrome:

33
Ovary, Liver, Kidney, Lymph node, Thyroid, Breast, Myeloid, B cells, Endothelial, Fetal liver, Fetal thyroid, Pituitary

Animal Models for Ovarian Hyperstimulation Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ovarian Hyperstimulation Syndrome

Sources:
51PubMed
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Articles related to Ovarian Hyperstimulation Syndrome:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Ovarian hyperstimulation syndrome in systemic amyloidosis. (24433119)
2014
2
The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. (23295464)
2013
3
Spontaneous ovarian hyperstimulation syndrome. (23941020)
2013
4
Successful pregnancy complicated by spontaneous, familial, recurrent ovarian hyperstimulation syndrome: report of two cases. (23952048)
2013
5
Reproductive outcome following thawed embryo transfer in management of ovarian hyperstimulation syndrome. (24163797)
2013
6
Severe early ovarian hyperstimulation syndrome following GnRH agonist trigger with the addition of 1500 IU hCG. (23633553)
2013
7
Pregnancy with 15 live fetuses and severe ovarian hyperstimulation syndrome after ovulation induction and intrauterine insemination. (23971265)
2013
8
Ovarian hyperstimulation syndrome- an optimal solution for an unresolved enigma. (24191960)
2013
9
Quadruplet pregnancy complicated by ovarian hyperstimulation syndrome with spontaneous ovulation. (23157058)
2012
10
Ovarian hyperstimulation syndrome complicated by severe community-acquired pneumonia due to methicillin-resistant Staphylococcus aureus positive for Panton-Valentine leukocidin. (22175531)
2012
11
Etiology of ovarian hyperstimulation syndrome. (22503413)
2012
12
Symptomatic isolated pleural effusion as an atypical presentation of ovarian hyperstimulation syndrome. (22567522)
2011
13
Ovarian hyperstimulation syndrome in a patient treated with tamoxifen for breast cancer. (21762898)
2011
14
Ascites ultrafiltration and concentration-reinfusion in severe ovarian hyperstimulation syndrome. (21475099)
2011
15
Spontaneous ovarian hyperstimulation syndrome caused by a follicle-stimulating hormone-secreting pituitary macroadenoma in an early pubertal girl. (20215777)
2010
16
Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. (19591989)
2010
17
Ovarian hyperstimulation syndrome: steps to maximize success and minimize effect for assisted reproductive outcome. (19356753)
2010
18
Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma: incidental pregnancy triggers a catastrophic event. (19356755)
2009
19
Ovarian hyperstimulation syndrome: a potentially fatal complication of early pregnancy. (18403169)
2008
20
Continuous vaginal and bilateral thoracic fluid drainage for management of severe ovarian hyperstimulation syndrome. (18958770)
2008
21
Effects of gonadotropin-releasing hormone antagonists on the expression of vascular endothelial growth factor and its receptors in a rat model of ovarian hyperstimulation syndrome. (19102964)
2008
22
Removal of ascites up to 7.5 liters on one occasion and 45 liters in total may be safe in patients with severe ovarian hyperstimulation syndrome. (19031224)
2008
23
Human albumin does not prevent ovarian hyperstimulation syndrome in assisted reproductive technology program: a prospective randomized placebo-controlled double blind study. (17313946)
2007
24
Internal jugular vein thrombosis and ovarian hyperstimulation syndrome. (17606756)
2007
25
Isolated severe hydrothorax with respiratory distress as a main manifestation of ovarian hyperstimulation syndrome preceded by respiratory tract infection caused by Haemophilus influenzae. (17915416)
2007
26
Ovarian hyperstimulation syndrome caused by pituitary gonadotroph adenoma secreting follicle-stimulating hormone. (17267890)
2007
27
Jugular vein thrombosis with severe local and systemic inflammation in a woman with ovarian hyperstimulation syndrome. (16732386)
2006
28
A case of ovarian hyperstimulation syndrome associated with the methylenetetrahydrofolate reductase mutation gene. (16009185)
2005
29
Can we eliminate severe ovarian hyperstimulation syndrome? Not completely. (16024544)
2005
30
Request for information on unreported cases of severe ovarian hyperstimulation syndrome (OHSS). (15958406)
2005
31
New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome? (14998941)
2004
32
Intensive care and treatment of severe ovarian hyperstimulation syndrome]. (15485803)
2004
33
Serum leptin concentrations in patients with severe ovarian hyperstimulation syndrome during in vitro fertilization-embryo transfer treatment. (15374699)
2004
34
Predicted value of renin activity in a woman who had severe ovarian hyperstimulation syndrome with internal jugular vein thrombosis. (15482774)
2004
35
Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study. (14585874)
2003
36
Prediction of ovarian hyperstimulation syndrome. Challenging the estradiol mythos. (12660254)
2003
37
Preventing ovarian hyperstimulation syndrome by inhibiting the effects of vascular endothelial growth factor. (12746987)
2003
38
Ovarian hyperstimulation syndrome due to a mutation in the follicle- stimulating hormone receptor. (12930928)
2003
39
Treatment for ovarian hyperstimulation syndrome using an oral dopamine prodrug, docarpamine. (14503971)
2003
40
Ovarian hyperstimulation syndrome is associated with reversible impairment of vascular reactivity. (12477504)
2002
41
Ovarian hyperstimulation syndrome: an endocrinopathy? (11396659)
2001
42
Perforated duodenal ulcer associated with ovarian hyperstimulation syndrome: Case Report. (11139559)
2001
43
Central retinal artery occlusion associated with severe ovarian hyperstimulation syndrome. (11681515)
2001
44
Prevention of severe ovarian hyperstimulation syndrome in IVF with or without ICSI and embryo transfer: a modified 'coasting' strategy based on ultrasound for identification of high-risk patients. (11139531)
2001
45
Soluble ICAM-1 and E-selectin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome. (11438319)
2001
46
A case of spontaneous ovarian hyperstimulation syndrome with a potential mutation in the hCG/LH receptor gene. (10927070)
2000
47
The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome. (9687159)
1998
48
Severe ovarian hyperstimulation syndrome: is it really preventable by prophylactic intravenous albumin? (9389814)
1997
49
Status of the coagulation and fibrinolytic systems in ovarian hyperstimulation syndrome. (8751741)
1996
50
Severe ovarian hyperstimulation syndrome: role of peripheral vasodilation. (1743325)
1991

Genetic Variations for Ovarian Hyperstimulation Syndrome

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Ovarian Hyperstimulation Syndrome:

63
id Symbol AA change Variation SNP ID
1FSHRp.Thr449IleVAR_017244rs28928870
2FSHRp.Asp567AsnVAR_017245rs28928871
3FSHRp.Ser128TyrVAR_039279
4FSHRp.Thr449AlaVAR_039282
5FSHRp.Ile545ThrVAR_039284

Expression for genes affiliated with Ovarian Hyperstimulation Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ovarian Hyperstimulation Syndrome

Search GEO for disease gene expression data for Ovarian Hyperstimulation Syndrome.

Pathways for genes affiliated with Ovarian Hyperstimulation Syndrome

Sources:
54Reactome, 4Cell Signaling Technology, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN
See all sources

Pathways related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4KDR, VEGFA
2
Hide members
10.3FSHB, REN, CGA
3
Hide members
10.3F5, VEGFA, ALB
410.3KDR, REN, CDH5
510.3FSHR, CYP19A1, LHCGR
6
Hide members
10.3VEGFA, CDH5, KDR
7
Hide members
10.3VEGFA, CDH5, KDR
810.3KLKB1, VEGFA, KDR
910.2FSHB, FSHR, CYP19A1, CGA
10
Hide members
10.2FSHB, FSHR, CGA, LHCGR
11
Hide members
10.2FSHB, FSHR, CGA, LHCGR
12
Development Endothelin-1/EDNRA signaling
Hide members
10.2GNRH1, CGA, VEGFA, FSHB, KDR
13
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
14
Hide members
10.2FSHB, FSHR, CGA, GNRH1, LHCGR
15
Hide members
10.2GNRH1, CGA, CDH5, FSHB, KDR
1610.1LHCGR, BMP15, CGA, CYP19A1, FSHR, FSHB

Compounds for genes affiliated with Ovarian Hyperstimulation Syndrome

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1ganirelix45 2911.7FSHB, GNRH1, CGA
2nafarelin45 60 29 1113.6GNRH1, CYP19A1, CGA
3pge24510.6FSHR, REN, VEGFA, LHCGR
4organon4510.6CGB5, CGA, FSHB
5estradiol benzoate4510.6CGB5, CGA, GNRH1, CYP19A1
6goserelin45 29 1112.6GNRH1, LHCGR, CYP19A1, CGA
7heparin45 29 11 2413.6GNRH1, AZU1, CGA, VEGFA
8cyproteroneacetate4510.6REN, GNRH1, F5, CYP19A1
9cetrorelix45 29 1112.6CGB5, CGA, GNRH1, LHCGR
10flutamide45 60 1112.6CYP19A1, CGA, GNRH1, LHCGR
11clomiphene citrate4510.6CYP19A1, FSHB, CGB5, CGA, GNRH1
1217-hydroxyprogesterone45 2411.6CGB5, REN, CGA, CYP19A1, GNRH1
13leuprolide45 60 29 1113.6CGA, CGB5, GNRH1
14celecoxib45 60 29 50 11 2415.6KDR, CYP19A1, REN, VEGFA, ALB
15naloxone45 50 29 1113.5CGB5, GNRH1, ALB, CGA
16diethylstilbestrol45 29 1112.5CGB5, CGA, GNRH1, CYP19A1
17androstenedione45 2411.5GNRH1, CGA, FSHR, CGB5, REN, CYP19A1
18gnrh4510.5CGA, GNRH1, FSHR, FSHB, LHCGR, CYP19A1
19leuprolide acetate4510.5FSHB, CYP19A1, CGB5, LHCGR, CGA, GNRH1
20buserelin45 29 1112.5LHCGR, GNRH1, CGA, CGB5, CYP19A1, FSHB
21dehydroepiandrosterone sulfate4510.5CGA, GNRH1, CYP19A1, CGB5
22mifepristone45 60 29 1113.5GNRH1, CGA, AMH, CGB5, VEGFA, CYP19A1
23hydrocortisone45 2 60 1113.5F5, REN, CYP19A1, KDR, CDH5
243beta-hydroxysteroid4510.5LHCGR, CGB5, CGA, CYP19A1
25indomethacin45 60 29 1113.5CGA, CGB5, KDR, REN, ALB, CYP19A1
26isoproterenol45 1111.4CGB5, CDH5, GNRH1, LHCGR
27metformin45 50 1112.4CGA, F5, GNRH1, CYP19A1
28kininogen4510.4KLKB1, ALB, F5, REN
29cyclophosphamide45 50 1112.4CGB5, CYP19A1, CGA, F5, KDR
30prostacyclin4510.4CGA, KDR, REN, VEGFA, F5
31lisinopril45 11 2412.4ALB, REN, VEGFA
32folate4510.4CGB5, KDR, CGA, F5, ALB
33creatinine4510.4REN, CGB5, F5, CGA, IL6R, ALB
34progestin4510.4GNRH1, F5, CGA, CYP19A1, KDR, CGB5
35ribonucleic acid4510.4FSHB, LHCGR, GNRH1, CGA, CGB5, CDH5
36tamoxifen45 50 29 1113.4AMH, GNRH1, F5, CGA, CGB5, KDR
37prostaglandin f2alpha4510.4LHCGR, GNRH1, CGB5, CGA
38fibrinogen4510.4CDH5, KLKB1, ALB, IL6R, CGB5, F5
39acth4510.3FSHB, REN, CGB5, GNRH1, LHCGR
40steroid4510.3IL6R, LHCGR, GNRH1, F5, CGB5, CYP19A1
41vegf4510.3CGA, AZU1, KDR, F5, REN, CDH5
42thalidomide45 50 60 1113.2KDR, IL6R, VEGFA, AMH
43testosterone45 60 11 2413.2GNRH1, FSHB, LHCGR, ALB, AMH, FSHR
44progesterone45 60 29 11 2414.2GNRH1, AMH, CGB5, CYP19A1, IL6R, F5
45dexamethasone45 50 29 1113.2GNRH1, VEGFA, KDR, CGB5, REN, IL6R
46arginine4510.2KDR, LHCGR, GNRH1, F5, CGA, CGB5
47estradiol45 11 2412.2REN, CGA, LHCGR, CGB5, CDH5, CYP19A1
48methotrexate45 50 1112.1IL6R, CGA, ALB, CYP19A1, CGB5
49gefitinib45 50 1112.1VEGFA, KDR, CYP19A1, ALB
50lactate459.8ALB, F5, GNRH1, CGA, CGB5, KDR

GO Terms for genes affiliated with Ovarian Hyperstimulation Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3ALB, VEGFA, F5
2extracellular regionGO:0055769.6ALB, KLKB1, AZU1, AMH, GNRH1, F5
3extracellular spaceGO:0056159.6KLKB1, AMH, GNRH1, BMP15, F5, VEGFA

Biological processes related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1follicle-stimulating hormone signaling pathwayGO:04269910.6FSHB, FSHR
2female gamete generationGO:00729210.6BMP15, FSHR, FSHB
3cell maturationGO:04846910.5KDR, REN, VEGFA
4positive regulation of cell migrationGO:03033510.5CGA, VEGFA, FSHB, KDR
5positive regulation of positive chemotaxisGO:05092710.5VEGFA, KDR
6surfactant homeostasisGO:04312910.4VEGFA, KDR
7ovarian follicle developmentGO:00154110.4KDR, FSHB, VEGFA, BMP15, LHCGR
8positive regulation of cell proliferationGO:00828410.4CGA, VEGFA, IL6R, FSHB, KDR
9cell migration involved in sprouting angiogenesisGO:00204210.4KDR, VEGFA
10negative regulation of apoptotic processGO:04306610.3ALB, KDR, VEGFA, GNRH1, AZU1
11male gonad developmentGO:00858410.3FSHR, REN, LHCGR
12platelet degranulationGO:00257610.2F5, VEGFA, ALB
13positive regulation of focal adhesion assemblyGO:05189410.1KDR, VEGFA

Molecular functions related to Ovarian Hyperstimulation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1toxic substance bindingGO:01564310.3ALB, AZU1
2hormone activityGO:0051799.9FSHB, CGA, GNRH1, AMH

Products for genes affiliated with Ovarian Hyperstimulation Syndrome

  • Antibodies
  • Proteins
  • Lysates
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Sources for Ovarian Hyperstimulation Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet