MCID: OVR056
MIFTS: 23

Ovarian Primitive Germ Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5351
NCIt 46 C39986
UMLS 69 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to intrahepatic bile duct adenoma and mucinous cystadenofibroma. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 intrahepatic bile duct adenoma 10.5 AFP KRT7
2 mucinous cystadenofibroma 10.5 AFP SERPINA1
3 polyembryoma 10.5 AFP SERPINA1
4 malignant teratoma 10.5 AFP SALL4
5 bile duct cystadenocarcinoma 10.5 AFP KRT7
6 intratubular embryonal carcinoma 10.5 AFP KRT7
7 epithelioid trophoblastic tumor 10.4 KRT7 SALL4
8 renal pelvis carcinoma 10.4 AFP KRT7
9 testicular malignant germ cell cancer 10.4 AFP GPC3
10 choriocarcinoma of the testis 10.4 AFP KRT7
11 ovarian embryonal carcinoma 10.4 AFP GPC3
12 adenomatoid tumor 10.4 AFP KRT7
13 hepatic adenomas, familial 10.4 AFP GPC3
14 pancreatoblastoma 10.4 AFP SERPINA1
15 sertoli-leydig cell tumor 10.4 AFP KRT7
16 malignant biphasic mesothelioma 10.4 AFP KRT7
17 placental site trophoblastic tumor 10.3 GPC3 SALL4
18 extragonadal seminoma 10.3 AFP SALL4
19 horner's syndrome 10.3 GPC3 KRT7
20 non-gestational ovarian choriocarcinoma 10.3 SRY TEK
21 pancreatic cystadenocarcinoma 10.3 AFP SERPINA1
22 choriocarcinoma of ovary 10.3 SRY TEK
23 acinar cell carcinoma 10.3 AFP KRT7 SERPINA1
24 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 GPC3 SERPINA1
25 seminal vesicle tumor 10.2 AFP GPC3 KRT7
26 bile duct adenocarcinoma 10.2 AFP GPC3 KRT7
27 intrahepatic cholangiocarcinoma 10.2 AFP GPC3 KRT7
28 gastrointestinal system cancer 10.2 AFP GPC3 KRT7
29 hepatoblastoma 10.2 AFP GPC3 KRT7
30 atypical choroid plexus papilloma 10.2 KRT7 SRY
31 adenosquamous pancreas carcinoma 10.2 KRT7 TEK
32 cholangiocarcinoma 10.2 AFP GPC3 KRT7
33 inverted papilloma 10.2 KRT7 MSX2
34 granulosa cell tumor of the ovary 10.2 KRT7 SERPINA1
35 ovarian germ cell cancer 10.2 AFP HLX KRT7 SALL4
36 malignant germ cell tumor 10.1 AFP KPNA2
37 endodermal sinus tumor 10.1 AFP KRT7 SALL4 SERPINA1
38 liver cirrhosis 10.1 AFP GPC3 SERPINA1
39 testicular yolk sac tumor 10.0 AFP GPC3 SALL4 SERPINA1
40 cystadenofibroma 10.0 AFP KRT7 SERPINA1 SRY
41 germ cells tumors 10.0
42 pancreatic mucinous cystadenoma 9.9 EZH2 KRT7
43 carotid artery dissection 9.8 GPC3 SERPINA1
44 ovarian endodermal sinus tumor 6.9 AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.36 SRY
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.36 NKX2-5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.36 SRY
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.36 NKX2-5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.36 NKX2-5 SRY AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 AFP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.36 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 AFP

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
2 embryo MP:0005380 9.8 SALL4 SIRT1 TEK EZH2 GPC3 MSX2
3 endocrine/exocrine gland MP:0005379 9.76 AFP EZH2 HLX HOXB7 KPNA1 MSX2
4 hematopoietic system MP:0005397 9.61 EZH2 GPC3 HLX HOXB7 KPNA1 MSX2
5 homeostasis/metabolism MP:0005376 9.32 AFP EZH2 GPC3 HLX KPNA1 KRT7

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

Publications for Ovarian Primitive Germ Cell Tumor

Articles related to Ovarian Primitive Germ Cell Tumor:

# Title Authors Year
1
SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. ( 19295406 )
2009

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.78 KPNA1 KPNA2 KRT7 SIRT1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 EZH2 MSX2 NKX2-5 SALL4 SIRT1
3 embryonic hindlimb morphogenesis GO:0035116 9.46 GPC3 MSX2
4 outflow tract septum morphogenesis GO:0003148 9.43 MSX2 NKX2-5
5 NLS-bearing protein import into nucleus GO:0006607 9.32 KPNA1 KPNA2
6 heart trabecula formation GO:0060347 9.26 NKX2-5 TEK
7 ovulation from ovarian follicle GO:0001542 9.16 AFP SIRT1
8 modulation by virus of host process GO:0019054 8.96 KPNA1 KPNA2
9 regulation of DNA recombination GO:0000018 8.62 KPNA1 KPNA2
10 regulation of transcription, DNA-templated GO:0006355 10.01 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.46 EZH2 MSX2 NKX2-5 SALL4
2 sequence-specific DNA binding GO:0043565 9.43 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3 nuclear localization sequence binding GO:0008139 9.32 KPNA1 KPNA2
4 transcription factor binding GO:0008134 9.02 MSX2 NKX2-5 SALL4 SIRT1 SRY
5 protein binding GO:0005515 10.1 AFP EZH2 GPC3 HLX HOXB7 KPNA1

Sources for Ovarian Primitive Germ Cell Tumor

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11 DGIdb
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18 FMA
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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