MCID: OVR027
MIFTS: 25

Ovarian Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Squamous Cell Carcinoma

MalaCards integrated aliases for Ovarian Squamous Cell Carcinoma:

Name: Ovarian Squamous Cell Carcinoma 12 14 69
Ovarian Squamous Cell Neoplasm 12
Ovarian Squamous Cell Tumor 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5531 DOID:5532
UMLS 69 C1518739

Summaries for Ovarian Squamous Cell Carcinoma

MalaCards based summary : Ovarian Squamous Cell Carcinoma, also known as ovarian squamous cell neoplasm, is related to squamous cell carcinoma and cervicitis. An important gene associated with Ovarian Squamous Cell Carcinoma is CRP (C-Reactive Protein). The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and cervix.

Related Diseases for Ovarian Squamous Cell Carcinoma

Diseases related to Ovarian Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3
2 cervicitis 9.9
3 dermoid cyst 9.9
4 cystic teratoma 9.9
5 teratoma 9.9
6 vaginitis 9.7
7 papilloma 9.7
8 cervical intraepithelial neoplasia 9.7
9 gallbladder squamous cell carcinoma 9.5 CRP LINC01191

Graphical network of the top 20 diseases related to Ovarian Squamous Cell Carcinoma:



Diseases related to Ovarian Squamous Cell Carcinoma

Symptoms & Phenotypes for Ovarian Squamous Cell Carcinoma

Drugs & Therapeutics for Ovarian Squamous Cell Carcinoma

Drugs for Ovarian Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Liver Extracts Phase 3,Phase 2,Phase 1
4 Adjuvants, Anesthesia Phase 3
5 Analgesics Phase 3,Phase 1
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Central Nervous System Depressants Phase 3
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3,Phase 1
13 Cola Nutraceutical Phase 3,Phase 2,Phase 1
14
Indinavir Approved Phase 2 150378-17-9 5362440
15
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
16
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
17
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
18
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
19
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
20
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
21
Ifosfamide Approved Phase 2 3778-73-2 3690
22
Lenograstim Approved Phase 2,Phase 1 135968-09-1
23
Mechlorethamine Approved Phase 2 51-75-2 4033
24 Thiotepa Approved Phase 2 52-24-4 5453
25
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
26
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
27
nivolumab Approved Phase 2,Phase 1 946414-94-4
28
Pembrolizumab Approved Phase 2,Phase 1 1374853-91-4
29
Everolimus Approved Phase 2 159351-69-6 6442177
30
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
31
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
32
Docetaxel Approved May 1996, Investigational Phase 1, Phase 2 114977-28-5 148124 9877265
33 Anti-HIV Agents Phase 2,Phase 1
34 Anti-Infective Agents Phase 2,Phase 1
35 Anti-Retroviral Agents Phase 2,Phase 1
36 Antiviral Agents Phase 2,Phase 1
37 Cytochrome P-450 CYP3A Inhibitors Phase 2
38 Cytochrome P-450 Enzyme Inhibitors Phase 2
39 HIV Protease Inhibitors Phase 2
40
protease inhibitors Phase 2
41 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
42 Albumin-Bound Paclitaxel Phase 2,Phase 1
43 Antimitotic Agents Phase 2,Phase 1
44
Erlotinib Hydrochloride Phase 1, Phase 2 183319-69-9 176871
45 Protein Kinase Inhibitors Phase 1, Phase 2
46 Antimetabolites Phase 2,Phase 1
47 Antimetabolites, Antineoplastic Phase 2,Phase 1
48 Immunosuppressive Agents Phase 2,Phase 1
49 Adjuvants, Immunologic Phase 2,Phase 1
50 Alkylating Agents Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 57)

id Name Status NCT ID Phase Drugs
1 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
4 A Study in Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers, and Squamous Cell Carcinoma of the Head and Neck Completed NCT01059643 Phase 2 LY2523355;pegfilgrastim
5 Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Squamous Cell Carcinoma of the Head and Neck Completed NCT00063895 Phase 1, Phase 2 erlotinib hydrochloride
6 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
7 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
8 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
9 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
10 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
11 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
12 A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204) Recruiting NCT02327078 Phase 1, Phase 2 Nivolumab (Phase 1);Epacadostat (Phase 1);Chemotherapy (Phase 1);Nivolumab (Phase 2);Epacadostat (Phase 2)
13 A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors Recruiting NCT02335918 Phase 1, Phase 2 Combination of varlilumab and nivolumab
14 Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors Recruiting NCT02644369 Phase 2
15 Study of LOXO-101 (Larotrectinib) in Subjects With NTRK Fusion Positive Solid Tumors (NAVIGATE) Recruiting NCT02576431 Phase 2 LOXO-101
16 Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusions or Non-fusion NTRK Cancers Recruiting NCT03215511 Phase 1, Phase 2 LOXO-195
17 A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors Active, not recruiting NCT02452424 Phase 1, Phase 2 PLX3397
18 Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations Active, not recruiting NCT02646319 Phase 2 Nanoparticle Albumin-Bound Rapamycin
19 Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors Active, not recruiting NCT02001623 Phase 1, Phase 2 Tisotumab Vedotin (HuMax-TF-ADC)
20 Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma Not yet recruiting NCT03174275 Phase 2 Durvalumab;Carboplatin;Nab-paclitaxel;Cisplatin
21 A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With Advanced Cancer Terminated NCT02042885 Phase 1, Phase 2 OPB-111001
22 A Phase I Trial of the Combination of AZD2014 and Weekly Paclitaxel. Unknown status NCT02193633 Phase 1 AZD2014 3 on/4 off & weekly paclitaxel;AZD2014 2 on/5 off & weekly paclitaxel
23 Laparoscopic Sentinel Lymph Node Localization in Operable Cervix Cancer Completed NCT00205010 Phase 1
24 Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors Completed NCT00006036 Phase 1 cisplatin;lurtotecan liposome
25 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
26 Dimesna in Treating Patients With Solid Tumors Who Are Undergoing Treatment With Cisplatin and Paclitaxel Completed NCT00003569 Phase 1 cisplatin;dimesna;paclitaxel
27 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
28 Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors Completed NCT00089362 Phase 1 alvespimycin hydrochloride
29 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
30 Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function Completed NCT00002901 Phase 1 docetaxel
31 Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors Completed NCT00066651 Phase 1
32 Immunotoxin Therapy in Treating Patients With Advanced Cancer Completed NCT00006981 Phase 1
33 Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors Completed NCT00014456 Phase 1 docetaxel;gemcitabine hydrochloride
34 Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer Completed NCT00004065 Phase 1 tanespimycin
35 Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed NCT00045006 Phase 1 vorinostat
36 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
37 Spectroscopy With Surface Coils and Decoupling Completed NCT00581815 Phase 1
38 Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor) Recruiting NCT01772004 Phase 1 Avelumab
39 A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors Recruiting NCT02573259 Phase 1 PF-06801591;PF-06801591
40 Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors Recruiting NCT02658214 Phase 1 paclitaxel + carboplatin;carboplatin + etoposide;gemcitabine + carboplatin;nab-paclitaxel (paclitaxel-albumin) + carboplatin;oxaliplatin + 5-fluorouracil (5FU) + leucovorin (calcium folinate/folinic acid);nab-paclitaxel (paclitaxel-albumin) + gemcitabine;cisplatin + 5-fluorouracil (5FU)
41 A Study Evaluating MM-310 in Patients With Solid Tumors Recruiting NCT03076372 Phase 1 MM-310
42 ACTolog in Patients With Solid Cancers Recruiting NCT02876510 Phase 1 Fludarabine;Cyclophosphamide
43 Safety Study of MGD009 in B7-H3-expressing Tumors Recruiting NCT02628535 Phase 1
44 A CR-UK Phase I Trial of LY3143921 Recruiting NCT03096054 Phase 1 LY3143921 hydrate
45 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
46 Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors and HIV Infection Terminated NCT01249443 Phase 1 vorinostat;carboplatin;paclitaxel
47 Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction Withdrawn NCT02567396 Phase 1 Talazoparib
48 Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy Unknown status NCT01265472
49 Performance of PET 18 F-FDG Coupled to CT With Contrast Injection Iodized in the Diagnosis of Early Recurrences of Head and Neck Carcinoma Treated With Concurrent Chemoradiation. Comparison With 18F-FDG PET Coupled With CT Not Injected With Filling CT Sta Completed NCT02510872
50 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442

Search NIH Clinical Center for Ovarian Squamous Cell Carcinoma

Genetic Tests for Ovarian Squamous Cell Carcinoma

Anatomical Context for Ovarian Squamous Cell Carcinoma

MalaCards organs/tissues related to Ovarian Squamous Cell Carcinoma:

39
Liver, Lung, Cervix, Breast, Kidney, Prostate, Endothelial

Publications for Ovarian Squamous Cell Carcinoma

Articles related to Ovarian Squamous Cell Carcinoma:

(show all 15)
id Title Authors Year
1
Pure Primary Ovarian Squamous Cell Carcinoma Perforating the Rectum. ( 28316851 )
2017
2
Case of pure ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin but responsive to monotherapy with weekly irinotecan. ( 25511544 )
2015
3
Pure primary ovarian squamous cell carcinoma: A case report and review of the literature. ( 25435984 )
2015
4
Clinical experience in ovarian squamous cell carcinoma arising from mature cystic teratoma: A rare entity. ( 25105100 )
2014
5
De novo Ovarian Squamous Cell Carcinoma. A Case Report and Review of Literature. ( 24426735 )
2013
6
Ovarian squamous cell carcinoma arising from mature cystic teratoma. ( 21684828 )
2011
7
Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report. ( 21467082 )
2011
8
Bilateral ovarian squamous cell carcinoma with an antecedent dermoid cyst in the left ovary. ( 21518128 )
2011
9
Metastatic ovarian squamous cell carcinoma. ( 18465040 )
2008
10
HPV induced ovarian squamous cell carcinoma: case report and review of the literature. ( 17333225 )
2007
11
A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective. ( 15790463 )
2005
12
A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration. ( 11104632 )
2000
13
Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. ( 8651358 )
1996
14
Pure primary ovarian squamous cell carcinoma. ( 3276582 )
1988
15
Ovarian squamous cell carcinoma derived from a dermoid cyst presenting as vaginal metastasis and the implication of its steroid receptor levels--two case reports. ( 3943751 )
1986

Variations for Ovarian Squamous Cell Carcinoma

Expression for Ovarian Squamous Cell Carcinoma

Search GEO for disease gene expression data for Ovarian Squamous Cell Carcinoma.

Pathways for Ovarian Squamous Cell Carcinoma

GO Terms for Ovarian Squamous Cell Carcinoma

Sources for Ovarian Squamous Cell Carcinoma

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60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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