MCID: OVR063
MIFTS: 48

Overnutrition malady

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Summaries for Overnutrition

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65Wikipedia, 33MalaCards
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Wikipedia:65 Overnutrition or hyperalimentation is a form of malnutrition in which nutrients are oversupplied... more...

MalaCards: Overnutrition is related to obesity and insulin resistance. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are TCR signaling in naive CD4+ T cells and HIF-1-alpha transcription factor network. The compounds alpha msh and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Overnutrition

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8Disease Ontology, 62UMLS, 27ICD9CM, 58SNOMED-CT
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Aliases & Descriptions:

overnutrition 8 62


External Ids:

Disease Ontology8 DOID:654
SNOMED-CT58 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

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17GeneCards, 18GeneDecks
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Diseases related to Overnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9LEP, AKT1, AGRP, INS
2insulin resistance30.5INS, LEP, AKT1, CDKN3
3atherosclerosis30.2INS, LEP, AKT1, CDKN3
4breast cancer30.0CDKN3, INS, LEP, AKT1, CRAT
5gestational diabetes30.0LEP, INS
6glucose intolerance30.0LEP, INS
7thyroiditis10.4
8hepatitis10.1
9proteus syndrome10.1CDKN3
10acquired generalized lipodystrophy10.1LEP
11leopard syndrome10.1CDKN3
12rabson-mendenhall syndrome10.1INS
13eating disorder10.1LEP, AGRP
14anorexia nervosa10.0LEP, AGRP
15familial partial lipodystrophy10.0LEP, INS
16fetal macrosomia10.0LEP, INS
17bronchitis10.0AGRP, LEP
18congenital generalized lipodystrophy type 210.0INS, LEP
19metabolic syndrome x10.0INS, LEP
20acanthosis nigricans10.0LEP, INS
21anovulation10.0LEP, INS
22morbid obesity10.0INS, LEP
23amenorrhea10.0LEP, INS
24growth hormone deficiency10.0LEP, INS
25hypopituitarism10.0INS, LEP
26hyperandrogenism10.0LEP, INS
27lipodystrophy10.0INS, LEP
28acromegaly10.0LEP, INS
29fatty liver disease10.0LEP, INS
30hypogonadism10.0LEP, INS
31tuberous sclerosis10.0CDKN3, AKT1
32prader-willi syndrome10.0INS, AGRP, LEP
33hyperthyroidism10.0LEP, INS
34hypothyroidism10.0AGRP, LEP, INS
35insulinoma10.0CRAT, INS, CDKN3
36hypertriglyceridemia10.0INS, LEP
37diabetic retinopathy10.0AKT1, INS
38coronary artery disease10.0INS, LEP, CRAT
39primary hyperoxaluria10.0INS, LEP
40short stature10.0LEP, INS
41type 1 diabetes mellitus10.0LEP, CDKN3, INS
42t-cell leukemia10.0CRAT, AKT1, CDKN3
43endometrial carcinoma10.0CRAT, CDKN3, AKT1
44galactosemia10.0LEP, INS, CDKN3
45prostate cancer10.0AKT1, CDKN3, CRAT
46astrocytoma10.0AKT1, CRAT, CDKN3
47polycystic ovary syndrome10.0LEP, INS
48burns10.0
49hypervitaminosis a10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Symptoms for Overnutrition

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Drugs & Therapeutics for Overnutrition

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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33MalaCards
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MalaCards organs/tissues related to Overnutrition:

33
Thyroid, Heart, Pituitary, Skeletal muscle, Testes, Brain, Breast, Fetal lung, Adipocyte, Endothelial, Liver, Lung, Kidney, Bone, Spinal cord, Cerebellum

Animal Models for Overnutrition or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Overnutrition:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8AGRP, AKT1, LEP, INS
2MP:00107718.5FTO, AKT1, LEP, INS
3MP:00053758.4AGRP, FTO, AKT1, LEP, INS
4MP:00053698.3CRAT, AKT1, LEP, INS
5MP:00053868.3INS, LEP, AKT1, FTO, AGRP
6MP:00036318.2AGRP, BCL10, AKT1, LEP, INS
7MP:00053908.2INS, LEP, AKT1, FTO
8MP:00053878.2INS, LEP, AKT1, FTO, BCL10
9MP:00107687.9INS, LEP, AKT1, FTO, BCL10, AGRP
10MP:00053847.8INS, LEP, AKT1, BCL10, CRAT
11MP:00053787.5INS, LEP, AKT1, FTO, CRAT, AGRP
12MP:00053767.5INS, LEP, AKT1, FTO, CRAT, AGRP

Publications for Overnutrition

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Sources:
52PubMed
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Articles related to Overnutrition:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Regulation of fetal lung development in response to maternal overnutrition. (24033542)
2013
2
The paradox of overnutrition in aging and cognition. (23682739)
2013
3
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. (23383303)
2013
4
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. (23900419)
2013
5
Oxidative stress programming in a rat model of postnatal early overnutrition--role of insulin resistance. (22819562)
2013
6
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. (22895107)
2013
7
Role of TRIB3 in diabetic and overnutrition-induced atherosclerosis. (22275081)
2012
8
Muscle endothelial-dependent microvascular dysfunction in adulthood due to early postnatal overnutrition. (22484032)
2012
9
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. (20110268)
2010
10
Symposium 1: Overnutrition: consequences and solutions. Foresight Report: the obesity challenge ahead. (19954564)
2010
11
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. (19553674)
2009
12
Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI. (18407907)
2008
13
Under- and overnutrition dynamics in Chinese children and adults (1991-2004). (17637598)
2008
14
Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. (17158475)
2007
15
Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. (17991666)
2007
16
Patterns, distribution, and determinants of under- and overnutrition: a population-based study of women in India. (16960179)
2006
17
Lipotoxicity, overnutrition and energy metabolism in aging. (16630750)
2006
18
Hypoadiponectinemia: a common basis for diseases associated with overnutrition. (16901415)
2006
19
The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. (14998807)
2004
20
Gastric inhibitory polypeptide links overnutrition to obesity. (12584208)
2003
21
Energy metabolism of young rats after early postnatal overnutrition. (12207840)
2002
22
Overnutrition and nutritional deficiency contribute to metabolic syndrome and atherosclerosis in Asian Indians. (12093466)
2002
23
Overnutrition and undernutrition as modifiers of metabolic processes in disease states. (10919956)
2000
24
Overnutrition in spiny mice (Acomys cahirinus): beta-cell expansion leading to rupture and overt diabetes on fat-rich diet and protective energy-wasting elevation in thyroid hormone on sucrose-rich diet. (10751749)
2000
25
Predicting under- and overnutrition among women of reproductive age: a population-based study in central Java, Indonesia. (10948386)
2000
26
The effect of under- and overnutrition on essential fatty acid metabolism in childhood. (9725653)
1998
27
Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions. (2156213)
1990
28
Overnutrition: an epidemic problem in pet animal practice? (2658284)
1989
29
Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. (3080654)
1986
30
Dietary-induced alterations in thyroid hormone metabolism during overnutrition. (500814)
1979
31
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
32
Effect of overnutrition and undernutrition on cellularity of rat epididymal fat pad. (1027950)
1976
33
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. (4826273)
1974
34
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. 3. Food consumption and weight gains. (4826268)
1974
35
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VI. The parathyroid glands and the thyroid C-cells. (4826271)
1974
36
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VII. Cervical vertebrae and spinal cord. (4826272)
1974
37
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. II. Design of experiment. (4826266)
1974
38
Infantile overnutrition. (4718856)
1973
39
Infantile overnutrition in the first year of life: a field study in Dudley, Worcestershire. (4642789)
1972
40
Overnutrition in West German children. (4105689)
1971
41
Behavioural responses of rats to early overnutrition. (5531295)
1970
42
UNDER-NUTRITION AND OVERNUTRITION IN TWO NEW JERSEY COMMUNITIES. (14327705)
1965
43
Some consequences of overnutrition with minerals. (13712775)
1961
44
Some psychologic considerations concerned with the problem of overnutrition. (13738289)
1961
45
The effect of age on the somatic and visceral response to overnutrition in the rat. Proc. Soc. Endocr. 60th. (13439103)
1957
46
Overnutrition for the child: blessing or curse? (13452251)
1957
47
Atherosclerosis: overnutrition or malnutrition? (14398671)
1955
48
Obesity: overnutrition or disease of metabolism? (13080244)
1953
49
Overnutrition and undernutrition. I. Causes. (13098048)
1953
50
Overnutrition and obesity. (12990685)
1952

Variations for Overnutrition

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Expression for genes affiliated with Overnutrition

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 30KEGG, 51PharmGKB, 61Tocris Bioscience, 55Reactome, 54R&D Systems, 53QIAGEN
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Pathways related to Overnutrition according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCR signaling in naive CD8+ T cells38
9.6BCL10, AKT1
29.6AKT1, LEP
39.6AKT1, LEP
49.6LEP, AKT1
59.4LEP, INS
6
Show member pathways
9.4INS, AKT1
79.4INS, AKT1
89.4INS, AKT1
99.4INS, AKT1
10
Show member pathways
Insulin Pathway38
9.4AKT1, INS
11
Show member pathways
9.4AKT1, INS
129.3AGRP, AKT1, LEP
139.0INS, LEP, AKT1
14
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.0INS, LEP, AKT1
15
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0AKT1, LEP, INS
16
Show member pathways
9.0AKT1, LEP, INS
17
Show member pathways
9.0AKT1, LEP, INS
18
Show member pathways
8.2CRAT, AKT1, LEP, INS

Compounds for genes affiliated with Overnutrition

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB
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Compounds related to Overnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1alpha msh4510.1LEP, AGRP
2oxyntomodulin45 6110.9LEP, AGRP
3exenatide45 1110.8INS, LEP
4sibutramine45 1110.8INS, LEP
5pramlintide45 1110.8LEP, INS
6beta-hydroxybutyrate459.8INS, LEP
7acipimox45 2910.8INS, LEP
8ptdins(3)p459.8CDKN3, AKT1
9nash459.7INS, LEP
10intralipid459.7LEP, INS
11telmisartan45 29 1111.6INS, LEP
12cortisone45 2410.6LEP, INS
13cocaine45 1110.6AGRP, LEP, CDKN3
14orlistat45 61 1111.5INS, LEP
152-deoxyglucose45 1110.5AKT1, AGRP, INS
16inositol459.5CDKN3, LEP, AKT1
17aicar45 24 1111.4INS, AKT1, LEP
18acth459.4AGRP, INS, LEP
19metformin45 51 1111.4LEP, AKT1, INS
20troglitazone45 29 61 1112.4INS, AKT1, LEP
21ganciclovir45 1110.1LEP, CRAT, CDKN3
22gaba459.0CDKN3, CRAT, LEP
23rapamycin458.9INS, AKT1, CDKN3, LEP
24ly294002458.9INS, LEP, AKT1, CDKN3
25wortmannin458.9CDKN3, INS, AKT1, LEP
26n acetylcysteine458.8LEP, AKT1, CRAT
27etoposide45 51 61 1111.8CDKN3, CRAT, AKT1
28nmda45 299.8LEP, CDKN3, AKT1
29phosphatidylinositol458.8INS, LEP, AKT1, CDKN3
30cysteine458.7AGRP, AKT1, CDKN3, LEP
31butyrate458.7LEP, CDKN3, AKT1, CRAT
32acetylcholine45 51 29 24 1112.7CRAT, AKT1, CDKN3, LEP
33tamoxifen45 51 29 1111.7LEP, AKT1, CRAT
34fatty acid458.7AGRP, CRAT, LEP, INS
35alanine458.7CDKN3, BCL10, AKT1, INS
36cisplatin45 51 61 1111.7CRAT, AKT1, LEP, CDKN3
37cycloheximide458.6LEP, CRAT, CDKN3, AKT1
38h2o2458.6LEP, AKT1, CRAT, CDKN3
39gnrh458.6CRAT, INS, LEP, AKT1
40epinephrine45 24 1110.6INS, AKT1, LEP, CRAT
41vegf458.6AKT1, CRAT, LEP, CDKN3
42creatinine458.6CRAT, AKT1, LEP, INS
43ibmx45 61 2910.5INS, CRAT, AKT1, CDKN3
44dexamethasone45 51 29 1111.5AKT1, LEP, INS, CRAT
45arginine458.5LEP, AKT1, INS, CRAT
46lipid458.2BCL10, CRAT, AKT1, LEP, INS
47testosterone45 61 24 1111.1LEP, CDKN3, INS, CRAT, AKT1
48glutamate458.1INS, LEP, AKT1, CDKN3, CRAT
49estrogen458.1CDKN3, INS, LEP, AKT1, CRAT
50serine457.7CRAT, BCL10, INS, CDKN3, LEP, AKT1

GO Terms for genes affiliated with Overnutrition

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16Gene Ontology
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Biological processes related to Overnutrition according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.1LEP, AGRP
2eating behaviorGO:04275510.0LEP, AGRP
3response to foodGO:0320949.9AKT1, BCL10
4response to insulinGO:0328689.9LEP, AGRP
5adipose tissue developmentGO:0606129.8LEP, FTO
6positive regulation of insulin receptor signaling pathwayGO:0466289.8INS, LEP
7positive regulation of lipid biosynthetic processGO:0468899.7INS, AKT1
8negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.7AKT1, INS
9positive regulation of cellular protein metabolic processGO:0322709.7INS, AKT1
10positive regulation of nitric-oxide synthase activityGO:0510009.7AKT1, INS
11positive regulation of glycogen biosynthetic processGO:0457259.7INS, AKT1
12negative regulation of proteolysisGO:0458619.7INS, AKT1
13cellular response to mechanical stimulusGO:0712609.6BCL10, AKT1
14positive regulation of glucose importGO:0463269.6INS, AKT1
15positive regulation of nitric oxide biosynthetic processGO:0454299.6AKT1, INS
16endocrine pancreas developmentGO:0310189.6INS, AKT1
17glucose transportGO:0157589.5INS, AKT1
18positive regulation of MAPK cascadeGO:0434109.5INS, LEP
19glucose homeostasisGO:0425939.4INS, AKT1
20glucose metabolic processGO:0060069.3AKT1, LEP, INS
21positive regulation of cell growthGO:0303079.3INS, AKT1
22regulation of insulin secretionGO:0507969.1INS, LEP

Molecular functions related to Overnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5BCL10, INS

Products for genes affiliated with Overnutrition

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Sources for Overnutrition

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet