MCID: OVR063
MIFTS: 44

Overnutrition malady

Summaries for Overnutrition

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Overnutrition is a form of malnutrition in which nutrients are oversupplied relative to the amounts... more...

MalaCards: Overnutrition is related to obesity and atherosclerosis. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development Leptin signaling via PI3K-dependent pathway. The compounds fatty acid and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Aliases & Classifications for Overnutrition

About this section
Sources:
8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
See all sources

Aliases & Descriptions:

overnutrition 8 60


External Ids:

Disease Ontology8 DOID:654
SNOMED-CT56 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Overnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9AKT1, AGRP, INS, LEP
2atherosclerosis30.2AKT1, CDKN3, INS, LEP
3ischemia29.9AKT1, CDKN3
4gestational diabetes29.9INS, LEP
5thyroiditis10.4
6breast cancer10.1
7hepatitis10.1
8narcolepsy10.0LEP
9acquired generalized lipodystrophy10.0LEP
10proteus syndrome10.0CDKN3
11osteoarthritis10.0CDKN3
12leopard syndrome10.0CDKN3
13cowden disease10.0CDKN3
14adenocarcinoma10.0AKT1
15hepatitis b10.0CRAT
16neuroblastoma10.0AKT1
17pancreatitis10.0INS
18rabson-mendenhall syndrome10.0INS
19cushing's syndrome10.0INS
20multiple myeloma10.0AKT1
21hepatoblastoma10.0CRAT
22anorexia nervosa10.0AGRP, LEP
23myeloma10.0CDKN3, AKT1
24thyroid cancer10.0CDKN3, AKT1
25tuberculosis10.0CRAT, CDKN3
26tuberous sclerosis10.0AKT1, CDKN3
27eating disorder10.0LEP, AGRP
28colon cancer10.0AKT1, CDKN3
29arthritis10.0CDKN3, LEP
30choriocarcinoma10.0LEP, CRAT
31liver cirrhosis10.0LEP
32thyrotoxicosis10.0INS
33rhabdomyosarcoma10.0AKT1, CRAT
34familial partial lipodystrophy10.0LEP, INS
35fetal macrosomia10.0INS, LEP
36congenital generalized lipodystrophy type 210.0LEP, INS
37ovarian cancer10.0CDKN3, AKT1
38hypoglycemia10.0INS, CDKN3
39morbid obesity10.0INS, LEP
40metabolic syndrome x10.0LEP, INS
41myopathy10.0CRAT, INS
42anovulation10.0INS, LEP
43acanthosis nigricans10.0INS, LEP
44fatty liver disease10.0LEP, INS
45bronchitis10.0LEP, AGRP
46schizophrenia10.0INS, AKT1
47polycystic ovary syndrome10.0LEP, INS
48diabetic retinopathy10.0AKT1, INS
49colorectal cancer10.0AKT1, BCL10
50t-cell leukemia10.0CDKN3, AKT1, CRAT

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Clinical Features for Overnutrition

About this section

Drugs & Therapeutics for Overnutrition

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Overnutrition

Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

Search CenterWatch for Overnutrition

Genetic Tests for Overnutrition

About this section

Anatomical Context for Overnutrition

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Overnutrition:

32
Thyroid, Heart, Pituitary, Skeletal muscle, Breast, Testes, Brain, Lung, Bone, Endothelial, Liver, Spinal cord, Adipocyte, Kidney, Cerebellum, Fetal lung

Animal Models for Overnutrition or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Overnutrition:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.6FTO, AGRP
2MP:00053767.8LEP, INS, FTO, AGRP, AKT1, CRAT
3MP:00053787.5CRAT, AKT1, AGRP, FTO, INS, LEP

Publications for Overnutrition

About this section
Sources:
50PubMed
See all sources

Articles related to Overnutrition:

(show top 50)    (show all 169)
idTitleAuthorsYear
1
Oxidative stress programming in a rat model of postnatal early overnutrition--role of insulin resistance. (22819562)
2013
2
Identification of a novel interorgan mechanism favoring energy storage in overnutrition. (24052907)
2013
3
Role of developmental overnutrition in pediatric obesity and type 2 diabetes. (24147926)
2013
4
Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep. (24313944)
2013
5
Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats. (24223863)
2013
6
Postnatal early overnutrition causes long-term renal decline in aging male rats. (24232634)
2013
7
Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep. (23287634)
2013
8
Overnutrition stimulates intestinal epithelium proliferation through I^-catenin signaling in obese mice. (23884889)
2013
9
Role of TRIB3 in diabetic and overnutrition-induced atherosclerosis. (22275081)
2012
10
Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance. (22708078)
2012
11
Looking beyond overnutrition for causes of epidemic metabolic disease. (22984158)
2012
12
Early postnatal overnutrition: potential roles of gastrointestinal vagal afferents and brain-derived neurotrophic factor. (22712064)
2012
13
Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats. (21752621)
2012
14
Exposure to maternal overnutrition and a high-fat diet during early postnatal development increases susceptibility to renal and metabolic injury later in life. (22160775)
2012
15
Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. (22394722)
2011
16
Developmental programming in response to maternal overnutrition. (22303323)
2011
17
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. (20110268)
2010
18
Symposium 1: Overnutrition: consequences and solutions. Foresight Report: the obesity challenge ahead. (19954564)
2010
19
Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet. (20194730)
2010
20
Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition. (20943806)
2010
21
Left ventricular hypertrophy induced by overnutrition early in life. (19359151)
2009
22
Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition. (18000310)
2007
23
Patterns, distribution, and determinants of under- and overnutrition: a population-based study of women in India. (16960179)
2006
24
Maternal overnutrition and pregnancy. (12455452)
2002
25
A global response to a global problem: the epidemic of overnutrition. (12571723)
2002
26
Overnutrition and undernutrition as modifiers of metabolic processes in disease states. (10919956)
2000
27
Overnutrition in spiny mice (Acomys cahirinus): beta-cell expansion leading to rupture and overt diabetes on fat-rich diet and protective energy-wasting elevation in thyroid hormone on sucrose-rich diet. (10751749)
2000
28
Influence of postnatal overnutrition and pregnancy on non-insulin dependent diabetes induced in Wistar rats by neonatal streptozotocin. (8867903)
1996
29
Chemical carcinogens and overnutrition in diet-related cancer. (1473226)
1992
30
Overnutrition: an epidemic problem in pet animal practice? (2658284)
1989
31
Overnutrition in the diabetic patient. (3035368)
1987
32
Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. (3080654)
1986
33
The influence of early postnatal overnutrition on peripheric thyroxine metabolism in rats. (3780867)
1986
34
Effect of early postnatal under- and overnutrition on the development of IgA plasma cells in mouse gut. (6806453)
1982
35
Effects of early overnutrition and undernutrition in rats on the metabolic responses to overnutrition in later life. (6950034)
1982
36
Overnutrition and obesity in childhood as a potential risk for chronic degenerative diseases in later life. (6760851)
1982
37
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
38
Late effects of neonatal undernutrition and overnutrition on pituitary-thyroidal and gonadal function. (810186)
1975
39
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. 3. Food consumption and weight gains. (4826268)
1974
40
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. II. Design of experiment. (4826266)
1974
41
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. IV. Clinical observations. (4826269)
1974
42
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. X. Discussion. (4826265)
1974
43
Infantile overnutrition. (4694699)
1973
44
Infantile overnutrition in the first year of life: a field study in Dudley, Worcestershire. (4642789)
1972
45
Overnutrition on resistance of dogs to distemper virus. (4288844)
1966
46
UNDER-NUTRITION AND OVERNUTRITION IN TWO NEW JERSEY COMMUNITIES. (14327705)
1965
47
Hypervitaminosis and overnutrition. (13993586)
1963
48
Some psychologic considerations concerned with the problem of overnutrition. (13738289)
1961
49
Atherosclerosis: overnutrition or malnutrition? (14398671)
1955
50
Overnutrition and undernutrition. I. Causes. (13098048)
1953

Genetic Variations for Overnutrition

About this section

Expression for genes affiliated with Overnutrition

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

About this section
Sources:
52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Overnutrition

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
See all sources

Compounds related to Overnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fatty acid4410.5AGRP
2alpha msh4410.1LEP, AGRP
3oxyntomodulin44 5911.1LEP, AGRP
4exenatide44 1111.0LEP, INS
5gnrh4410.0AKT1, CRAT
6sibutramine44 1111.0INS, LEP
7pramlintide44 1111.0LEP, INS
8beta-hydroxybutyrate449.9INS, LEP
9acipimox44 2810.9INS, LEP
10intralipid449.9LEP, INS
11nash449.9INS, LEP
12telmisartan44 28 1111.9LEP, INS
13cortisone44 2410.9LEP, INS
14orlistat44 59 1111.9LEP, INS
15thiazolidinedione449.7INS, LEP
162-deoxyglucose44 1110.6AKT1, AGRP, INS
17aicar44 11 2411.6LEP, AKT1, INS
18metformin44 49 1111.6AKT1, LEP, INS
19ptdins(3)p449.6AKT1, CDKN3
20acth449.6LEP, INS, AGRP
21troglitazone44 28 59 1112.6INS, LEP, AKT1
22indole-3-carbinol449.5AKT1, CRAT
238-isoprostane449.5INS, LEP
24n acetylcysteine449.3AKT1, LEP, CRAT
25cocaine44 1110.3CDKN3, LEP, AGRP
26dexamethasone44 49 28 1112.3INS, AKT1, CRAT
27inositol449.3LEP, CDKN3, AKT1
28tamoxifen44 49 28 1112.2CRAT, AKT1, LEP
29ganciclovir44 1110.2CRAT, LEP, CDKN3
30serine449.1CDKN3, BCL10, LEP
31epinephrine44 11 2411.1LEP, CRAT, AKT1, INS
32creatinine449.1CRAT, AKT1, LEP, INS
33gaba449.0LEP, CRAT, CDKN3
34etoposide44 49 59 1111.9AKT1, CRAT, CDKN3
35arginine448.9AKT1, INS, CRAT, LEP
36nmda44 289.9LEP, CDKN3, AKT1
37butyrate448.8LEP, CDKN3, AKT1, CRAT
38acetylcholine44 49 28 11 2412.8AKT1, CRAT, CDKN3, LEP
39rapamycin448.8LEP, INS, CDKN3, AKT1
40ly294002448.8AKT1, CDKN3, INS, LEP
41wortmannin448.8LEP, AKT1, CDKN3, INS
42norepinephrine44 11 2410.8LEP, INS, CRAT
43cisplatin44 49 59 1111.8CRAT, AKT1, LEP, CDKN3
44h2o2448.7CRAT, LEP, CDKN3, AKT1
45ibmx44 28 5910.7CDKN3, CRAT, AKT1, INS
46vegf448.6CDKN3, LEP, CRAT, AKT1
47phosphatidylinositol448.6AKT1, LEP, CDKN3, INS
48lipid448.4INS, BCL10, AKT1, CRAT, LEP
49testosterone44 59 11 2411.3CRAT, AKT1, CDKN3, INS, LEP
50alanine448.2AKT1, BCL10, INS, CDKN3

GO Terms for genes affiliated with Overnutrition

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Overnutrition according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.0LEP, AGRP
2positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
3positive regulation of lipid biosynthetic processGO:0468899.8INS, AKT1
4negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.8INS, AKT1
5positive regulation of cellular protein metabolic processGO:0322709.7INS, AKT1
6adipose tissue developmentGO:0606129.7FTO, LEP
7positive regulation of nitric-oxide synthase activityGO:0510009.7AKT1, INS
8positive regulation of glycogen biosynthetic processGO:0457259.7INS, AKT1
9negative regulation of proteolysisGO:0458619.5AKT1, INS
10endocrine pancreas developmentGO:0310189.5INS, AKT1
11positive regulation of glucose importGO:0463269.4INS, AKT1
12glucose metabolic processGO:0060069.4AKT1, INS, LEP
13positive regulation of nitric oxide biosynthetic processGO:0454299.2INS, AKT1

Products for genes affiliated with Overnutrition

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Overnutrition

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet