MCID: OVR063
MIFTS: 44

Overnutrition malady

Summaries for Overnutrition

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63Wikipedia, 32MalaCards
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Wikipedia:63 Overnutrition is a form of malnutrition in which nutrients are oversupplied relative to the amounts... more...

MalaCards: Overnutrition is related to obesity and atherosclerosis. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development Leptin signaling via PI3K-dependent pathway. The compounds fatty acid and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Aliases & Classifications for Overnutrition

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

overnutrition 8 60


External Ids:

Disease Ontology8 DOID:654
SNOMED-CT56 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Overnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9AKT1, AGRP, INS, LEP
2atherosclerosis30.2AKT1, CDKN3, INS, LEP
3ischemia29.9AKT1, CDKN3
4gestational diabetes29.9INS, LEP
5thyroiditis10.4
6breast cancer10.1
7hepatitis10.1
8narcolepsy10.0LEP
9acquired generalized lipodystrophy10.0LEP
10proteus syndrome10.0CDKN3
11osteoarthritis10.0CDKN3
12leopard syndrome10.0CDKN3
13cowden disease10.0CDKN3
14adenocarcinoma10.0AKT1
15hepatitis b10.0CRAT
16neuroblastoma10.0AKT1
17pancreatitis10.0INS
18rabson-mendenhall syndrome10.0INS
19cushing's syndrome10.0INS
20multiple myeloma10.0AKT1
21hepatoblastoma10.0CRAT
22anorexia nervosa10.0AGRP, LEP
23myeloma10.0CDKN3, AKT1
24thyroid cancer10.0CDKN3, AKT1
25tuberculosis10.0CRAT, CDKN3
26tuberous sclerosis10.0AKT1, CDKN3
27eating disorder10.0LEP, AGRP
28colon cancer10.0AKT1, CDKN3
29arthritis10.0CDKN3, LEP
30choriocarcinoma10.0LEP, CRAT
31liver cirrhosis10.0LEP
32thyrotoxicosis10.0INS
33rhabdomyosarcoma10.0AKT1, CRAT
34familial partial lipodystrophy10.0LEP, INS
35fetal macrosomia10.0INS, LEP
36congenital generalized lipodystrophy type 210.0LEP, INS
37ovarian cancer10.0CDKN3, AKT1
38hypoglycemia10.0INS, CDKN3
39morbid obesity10.0INS, LEP
40metabolic syndrome x10.0LEP, INS
41myopathy10.0CRAT, INS
42anovulation10.0INS, LEP
43acanthosis nigricans10.0INS, LEP
44fatty liver disease10.0LEP, INS
45bronchitis10.0LEP, AGRP
46schizophrenia10.0INS, AKT1
47polycystic ovary syndrome10.0LEP, INS
48diabetic retinopathy10.0AKT1, INS
49colorectal cancer10.0AKT1, BCL10
50t-cell leukemia10.0CDKN3, AKT1, CRAT

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Clinical Features for Overnutrition

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Drugs & Therapeutics for Overnutrition

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

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Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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32MalaCards
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MalaCards organs/tissues related to Overnutrition:

32
Thyroid, Heart, Pituitary, Skeletal muscle, Breast, Testes, Brain, Lung, Bone, Endothelial, Liver, Spinal cord, Adipocyte, Kidney, Cerebellum, Fetal lung

Animal Models for Overnutrition or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Overnutrition:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.6FTO, AGRP
2MP:00053767.8LEP, INS, FTO, AGRP, AKT1, CRAT
3MP:00053787.5CRAT, AKT1, AGRP, FTO, INS, LEP

Publications for Overnutrition

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50PubMed
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Articles related to Overnutrition:

(show top 50)    (show all 169)
idTitleAuthorsYear
1
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. (23383303)
2013
2
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. (23900419)
2013
3
Long-term effects of early overnutrition in the heart of male adult rats: role of the renin-angiotensin system. (23755190)
2013
4
Identification of a novel interorgan mechanism favoring energy storage in overnutrition. (24052907)
2013
5
Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep. (24313944)
2013
6
Neuroinflammation in overnutrition-induced diseases. (23374717)
2013
7
Determinants of undernutrition and overnutrition among adolescents in developing countries. (23437681)
2012
8
Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet. (22510708)
2012
9
Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. (22394722)
2011
10
Socioeconomic and geographic patterning of under- and overnutrition among women in Bangladesh. (21346108)
2011
11
Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review. (21769766)
2011
12
Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities. (21813874)
2011
13
Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition. (21314736)
2011
14
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. (20110268)
2010
15
Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe. (20427725)
2010
16
Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet. (20194730)
2010
17
Socio-economic drivers of overnutrition in China. (20831706)
2010
18
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. (19553674)
2009
19
Left ventricular hypertrophy induced by overnutrition early in life. (19359151)
2009
20
Under- and overnutrition dynamics in Chinese children and adults (1991-2004). (17637598)
2008
21
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. (18854155)
2008
22
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. (18336062)
2008
23
Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism. (18635655)
2008
24
Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. (17991666)
2007
25
Patterns, distribution, and determinants of under- and overnutrition: a population-based study of women in India. (16960179)
2006
26
Lipotoxicity, overnutrition and energy metabolism in aging. (16630750)
2006
27
Hypoadiponectinemia: a common basis for diseases associated with overnutrition. (16901415)
2006
28
A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? (15793228)
2005
29
Overnutrition and nutritional deficiency contribute to metabolic syndrome and atherosclerosis in Asian Indians. (12093466)
2002
30
Fetal overnutrition in polynesian pregnancies and in gestational diabetes may lead to dysregulation of the adipoinsular axis in offspring. (12196424)
2002
31
Nutritional status in acute stroke: undernutrition versus overnutrition in different stroke subtypes. (9786616)
1998
32
Chemical carcinogens and overnutrition in diet-related cancer. (1473226)
1992
33
Metabolic studies in human obesity during overnutrition and undernutrition: thermogenic and hormonal responses to norepinephrine. (3456075)
1986
34
Effects of early overnutrition and undernutrition in rats on the metabolic responses to overnutrition in later life. (6950034)
1982
35
Overnutrition and obesity in childhood as a potential risk for chronic degenerative diseases in later life. (6760851)
1982
36
The development of brown adipose tissue during experimental overnutrition in rats. (7319681)
1981
37
Dietary fibre in under- and overnutrition in childhood. (6254444)
1980
38
Dietary-induced alterations in thyroid hormone metabolism during overnutrition. (500814)
1979
39
Nutrition, overnutrition, and obesity in the first year of line in MalmAP, Sweden. (1155083)
1975
40
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. 8. The ribs. (4826274)
1974
41
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. IX. The long bones. (4826275)
1974
42
Overnutrition. (4584294)
1973
43
Overnutrition in children. (4107419)
1971
44
Overnutrition in prenatal and neonatal life: a problem? (5318613)
1965
45
Body composition and body weight: criteria of overnutrition. (5318614)
1965
46
OVERNUTRITION. (14060833)
1963
47
Symposium on overnutrition; introductory remarks. (13700690)
1961
48
The effect of age on the somatic and visceral response to overnutrition in the rat. Proc. Soc. Endocr. 60th. (13439103)
1957
49
Overnutrition for the child: blessing or curse? (13452251)
1957
50
Obesity: overnutrition or disease of metabolism? (13080244)
1953

Genetic Variations for Overnutrition

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Expression for genes affiliated with Overnutrition

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Overnutrition

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Overnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fatty acid4410.5AGRP
2alpha msh4410.1LEP, AGRP
3oxyntomodulin44 5911.1LEP, AGRP
4exenatide44 1111.0LEP, INS
5gnrh4410.0AKT1, CRAT
6sibutramine44 1111.0INS, LEP
7pramlintide44 1111.0LEP, INS
8beta-hydroxybutyrate449.9INS, LEP
9acipimox44 2810.9INS, LEP
10intralipid449.9LEP, INS
11nash449.9INS, LEP
12telmisartan44 28 1111.9LEP, INS
13cortisone44 2410.9LEP, INS
14orlistat44 59 1111.9LEP, INS
15thiazolidinedione449.7INS, LEP
162-deoxyglucose44 1110.6AKT1, AGRP, INS
17aicar44 11 2411.6LEP, AKT1, INS
18metformin44 49 1111.6AKT1, LEP, INS
19ptdins(3)p449.6AKT1, CDKN3
20acth449.6LEP, INS, AGRP
21troglitazone44 28 59 1112.6INS, LEP, AKT1
22indole-3-carbinol449.5AKT1, CRAT
238-isoprostane449.5INS, LEP
24n acetylcysteine449.3AKT1, LEP, CRAT
25cocaine44 1110.3CDKN3, LEP, AGRP
26dexamethasone44 49 28 1112.3INS, AKT1, CRAT
27inositol449.3LEP, CDKN3, AKT1
28tamoxifen44 49 28 1112.2CRAT, AKT1, LEP
29ganciclovir44 1110.2CRAT, LEP, CDKN3
30serine449.1CDKN3, BCL10, LEP
31epinephrine44 11 2411.1LEP, CRAT, AKT1, INS
32creatinine449.1CRAT, AKT1, LEP, INS
33gaba449.0LEP, CRAT, CDKN3
34etoposide44 49 59 1111.9AKT1, CRAT, CDKN3
35arginine448.9AKT1, INS, CRAT, LEP
36nmda44 289.9LEP, CDKN3, AKT1
37butyrate448.8LEP, CDKN3, AKT1, CRAT
38acetylcholine44 49 28 11 2412.8AKT1, CRAT, CDKN3, LEP
39rapamycin448.8LEP, INS, CDKN3, AKT1
40ly294002448.8AKT1, CDKN3, INS, LEP
41wortmannin448.8LEP, AKT1, CDKN3, INS
42norepinephrine44 11 2410.8LEP, INS, CRAT
43cisplatin44 49 59 1111.8CRAT, AKT1, LEP, CDKN3
44h2o2448.7CRAT, LEP, CDKN3, AKT1
45ibmx44 28 5910.7CDKN3, CRAT, AKT1, INS
46vegf448.6CDKN3, LEP, CRAT, AKT1
47phosphatidylinositol448.6AKT1, LEP, CDKN3, INS
48lipid448.4INS, BCL10, AKT1, CRAT, LEP
49testosterone44 59 11 2411.3CRAT, AKT1, CDKN3, INS, LEP
50alanine448.2AKT1, BCL10, INS, CDKN3

GO Terms for genes affiliated with Overnutrition

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16Gene Ontology
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Biological processes related to Overnutrition according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.0LEP, AGRP
2positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
3positive regulation of lipid biosynthetic processGO:0468899.8INS, AKT1
4negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.8INS, AKT1
5positive regulation of cellular protein metabolic processGO:0322709.7INS, AKT1
6adipose tissue developmentGO:0606129.7FTO, LEP
7positive regulation of nitric-oxide synthase activityGO:0510009.7AKT1, INS
8positive regulation of glycogen biosynthetic processGO:0457259.7INS, AKT1
9negative regulation of proteolysisGO:0458619.5AKT1, INS
10endocrine pancreas developmentGO:0310189.5INS, AKT1
11positive regulation of glucose importGO:0463269.4INS, AKT1
12glucose metabolic processGO:0060069.4AKT1, INS, LEP
13positive regulation of nitric oxide biosynthetic processGO:0454299.2INS, AKT1

Products for genes affiliated with Overnutrition

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Sources for Overnutrition

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet