MCID: OVR063
MIFTS: 49

Overnutrition malady

Metabolic diseases category
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Summaries for Overnutrition

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Wikipedia:65 Overnutrition or hyperalimentation is a form of malnutrition in which nutrients are oversupplied... more...

MalaCards based summary: Overnutrition is related to obesity and gestational diabetes. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are TCR signaling in naive CD4+ T cells and HIF-1-alpha transcription factor network. The compounds alpha msh and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skeletal muscle, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Overnutrition

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Overnutrition, Aliases & Descriptions:

Name: Overnutrition 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:654
SNOMED-CT57 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

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Diseases related to Overnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.7INS, LEP, AKT1, AGRP
2gestational diabetes30.2INS, LEP
3insulin resistance30.2INS, LEP, AKT1, CDKN3
4glucose intolerance30.1LEP, INS
5atherosclerosis29.8INS, LEP, AKT1, CDKN3
6breast cancer29.6INS, LEP, AKT1, CRAT, CDKN3
7proteus syndrome10.5CDKN3
8acquired generalized lipodystrophy10.4LEP
9leopard syndrome10.4CDKN3
10rabson-mendenhall syndrome10.4INS
11thyroiditis10.4
12eating disorder10.2AGRP, LEP
13anorexia nervosa10.2AGRP, LEP
14familial partial lipodystrophy10.2INS, LEP
15fetal macrosomia10.2LEP, INS
16non-suppurative otitis media10.2LEP, AGRP
17congenital generalized lipodystrophy type 210.2LEP, INS
18metabolic syndrome x10.2INS, LEP
19acanthosis nigricans10.2LEP, INS
20morbid obesity10.2INS, LEP
21anovulation10.2INS, LEP
22amenorrhea10.2LEP, INS
23growth hormone deficiency10.2LEP, INS
24hypopituitarism10.2INS, LEP
25hyperandrogenism10.2INS, LEP
26hepatitis10.2
27lipodystrophy10.1LEP, INS
28acromegaly10.1INS, LEP
29fatty liver disease10.1LEP, INS
30hypogonadism10.1LEP, INS
31tuberous sclerosis10.1CDKN3, AKT1
32prader-willi syndrome10.1AGRP, LEP, INS
33hyperthyroidism10.1INS, LEP
34hypothyroidism10.1INS, LEP, AGRP
35insulinoma10.1CDKN3, CRAT, INS
36hypertriglyceridemia10.0INS, LEP
37diabetic retinopathy10.0AKT1, INS
38coronary artery anomaly10.0INS, LEP, CRAT
39primary hyperoxaluria10.0INS, LEP
40short stature10.0INS, LEP
41burns10.0
42hypervitaminosis a10.0
43cervicitis10.0
44ischemia10.0
45nutritional deficiency disease10.0
46epididymitis10.0
47endotheliitis10.0
48type 1 diabetes mellitus10.0INS, LEP, CDKN3
49t-cell leukemia10.0CDKN3, CRAT, AKT1
50endometrial carcinoma10.0AKT1, CRAT, CDKN3

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Symptoms for Overnutrition

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Drugs & Therapeutics for Overnutrition

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Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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MalaCards organs/tissues related to Overnutrition:

32
Thyroid, Heart, Skeletal muscle, Pituitary, Brain, Liver, Breast, Testes, Bone, Cerebellum, Spinal cord, Adipocyte, Kidney, Lung, Endothelial, Fetal lung

Animal Models for Overnutrition or affiliated genes

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MGI Mouse Phenotypes related to Overnutrition:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8AGRP, AKT1, LEP, INS
2MP:00107718.5FTO, AKT1, LEP, INS
3MP:00053758.4AGRP, FTO, AKT1, LEP, INS
4MP:00053698.3CRAT, AKT1, LEP, INS
5MP:00053868.3INS, LEP, AKT1, FTO, AGRP
6MP:00036318.2AGRP, BCL10, AKT1, LEP, INS
7MP:00053908.2INS, LEP, AKT1, FTO
8MP:00053878.2INS, LEP, AKT1, FTO, BCL10
9MP:00107687.9INS, LEP, AKT1, FTO, BCL10, AGRP
10MP:00053847.8INS, LEP, AKT1, BCL10, CRAT
11MP:00053787.5INS, LEP, AKT1, FTO, CRAT, AGRP
12MP:00053767.5INS, LEP, AKT1, FTO, CRAT, AGRP

Publications for Overnutrition

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Articles related to Overnutrition:

(show top 50)    (show all 175)
idTitleAuthorsYear
1
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. (25204637)
2014
2
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. (25082159)
2014
3
Impact of maternal overnutrition on gluconeogenic factors and methylation of the phosphoenolpyruvate carboxykinase promoter in the fetal and postnatal liver. (24452591)
2014
4
Regulation of fetal lung development in response to maternal overnutrition. (24033542)
2013
5
The paradox of overnutrition in aging and cognition. (23682739)
2013
6
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. (23383303)
2013
7
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. (23900419)
2013
8
Oxidative stress programming in a rat model of postnatal early overnutrition--role of insulin resistance. (22819562)
2013
9
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. (22895107)
2013
10
Muscle endothelial-dependent microvascular dysfunction in adulthood due to early postnatal overnutrition. (22484032)
2012
11
Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. (22394722)
2011
12
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. (20110268)
2010
13
Symposium 1: Overnutrition: consequences and solutions. Foresight Report: the obesity challenge ahead. (19954564)
2010
14
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. (19553674)
2009
15
Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI. (18407907)
2008
16
Under- and overnutrition dynamics in Chinese children and adults (1991-2004). (17637598)
2008
17
Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. (17158475)
2007
18
Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. (17991666)
2007
19
Patterns, distribution, and determinants of under- and overnutrition: a population-based study of women in India. (16960179)
2006
20
Lipotoxicity, overnutrition and energy metabolism in aging. (16630750)
2006
21
Hypoadiponectinemia: a common basis for diseases associated with overnutrition. (16901415)
2006
22
The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. (14998807)
2004
23
Gastric inhibitory polypeptide links overnutrition to obesity. (12584208)
2003
24
Energy metabolism of young rats after early postnatal overnutrition. (12207840)
2002
25
Overnutrition and nutritional deficiency contribute to metabolic syndrome and atherosclerosis in Asian Indians. (12093466)
2002
26
Overnutrition and undernutrition as modifiers of metabolic processes in disease states. (10919956)
2000
27
Overnutrition in spiny mice (Acomys cahirinus): beta-cell expansion leading to rupture and overt diabetes on fat-rich diet and protective energy-wasting elevation in thyroid hormone on sucrose-rich diet. (10751749)
2000
28
Predicting under- and overnutrition among women of reproductive age: a population-based study in central Java, Indonesia. (10948386)
2000
29
The effect of under- and overnutrition on essential fatty acid metabolism in childhood. (9725653)
1998
30
Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions. (2156213)
1990
31
Overnutrition: an epidemic problem in pet animal practice? (2658284)
1989
32
Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. (3080654)
1986
33
Dietary-induced alterations in thyroid hormone metabolism during overnutrition. (500814)
1979
34
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
35
Effect of overnutrition and undernutrition on cellularity of rat epididymal fat pad. (1027950)
1976
36
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. 3. Food consumption and weight gains. (4826268)
1974
37
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VII. Cervical vertebrae and spinal cord. (4826272)
1974
38
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. II. Design of experiment. (4826266)
1974
39
Infantile overnutrition. (4718856)
1973
40
Infantile overnutrition in the first year of life: a field study in Dudley, Worcestershire. (4642789)
1972
41
Overnutrition in West German children. (4105689)
1971
42
Behavioural responses of rats to early overnutrition. (5531295)
1970
43
UNDER-NUTRITION AND OVERNUTRITION IN TWO NEW JERSEY COMMUNITIES. (14327705)
1965
44
Some consequences of overnutrition with minerals. (13712775)
1961
45
Some psychologic considerations concerned with the problem of overnutrition. (13738289)
1961
46
The effect of age on the somatic and visceral response to overnutrition in the rat. Proc. Soc. Endocr. 60th. (13439103)
1957
47
Overnutrition for the child: blessing or curse? (13452251)
1957
48
Atherosclerosis: overnutrition or malnutrition? (14398671)
1955
49
Obesity: overnutrition or disease of metabolism? (13080244)
1953
50
Overnutrition and obesity. (12990685)
1952

Variations for Overnutrition

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Expression for genes affiliated with Overnutrition

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Expression patterns in normal tissues for genes affiliated with Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

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Pathways related to Overnutrition according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCR signaling in naive CD8+ T cells37
9.6BCL10, AKT1
29.6AKT1, LEP
39.6AKT1, LEP
49.6LEP, AKT1
59.4LEP, INS
6
Show member pathways
9.4INS, AKT1
79.4INS, AKT1
89.4INS, AKT1
99.4INS, AKT1
10
Show member pathways
Insulin Pathway37
9.4AKT1, INS
11
Show member pathways
9.4AKT1, INS
129.3AGRP, AKT1, LEP
139.0INS, LEP, AKT1
14
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.0INS, LEP, AKT1
15
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0AKT1, LEP, INS
16
Show member pathways
9.0AKT1, LEP, INS
17
Show member pathways
9.0AKT1, LEP, INS
18
Show member pathways
8.2CRAT, AKT1, LEP, INS

Compounds for genes affiliated with Overnutrition

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Compounds related to Overnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1alpha msh4410.1LEP, AGRP
2oxyntomodulin44 6110.9LEP, AGRP
3exenatide44 1110.8LEP, INS
4pramlintide44 1110.8INS, LEP
5sibutramine44 1110.8INS, LEP
6beta-hydroxybutyrate449.8LEP, INS
7acipimox44 2810.8LEP, INS
8ptdins(3)p449.8AKT1, CDKN3
9intralipid449.7INS, LEP
10nash449.7INS, LEP
11telmisartan44 28 1111.6INS, LEP
12cortisone44 2410.6LEP, INS
13cocaine44 1110.6LEP, CDKN3, AGRP
14orlistat44 61 1111.5LEP, INS
152-deoxyglucose44 1110.5AGRP, AKT1, INS
16inositol449.5CDKN3, AKT1, LEP
17aicar44 24 1111.4AKT1, LEP, INS
18acth449.4INS, LEP, AGRP
19metformin44 50 1111.4INS, LEP, AKT1
20troglitazone44 28 61 1112.4AKT1, LEP, INS
21ganciclovir44 1110.1LEP, CRAT, CDKN3
22gaba449.0CDKN3, CRAT, LEP
23rapamycin448.9INS, LEP, AKT1, CDKN3
24ly294002448.9INS, LEP, AKT1, CDKN3
25wortmannin448.9INS, LEP, AKT1, CDKN3
26n acetylcysteine448.8LEP, AKT1, CRAT
27etoposide44 50 61 1111.8AKT1, CRAT, CDKN3
28nmda44 289.8LEP, AKT1, CDKN3
29phosphatidylinositol448.8CDKN3, AKT1, LEP, INS
30cysteine448.7AGRP, CDKN3, AKT1, LEP
31butyrate448.7CDKN3, CRAT, AKT1, LEP
32acetylcholine44 50 28 24 1112.7CDKN3, CRAT, AKT1, LEP
33tamoxifen44 50 28 1111.7CRAT, AKT1, LEP
34fatty acid448.7INS, LEP, CRAT, AGRP
35alanine448.7INS, AKT1, BCL10, CDKN3
36cisplatin44 50 61 1111.7LEP, AKT1, CRAT, CDKN3
37cycloheximide448.6LEP, AKT1, CRAT, CDKN3
38h2o2448.6LEP, AKT1, CRAT, CDKN3
39gnrh448.6INS, LEP, AKT1, CRAT
40epinephrine44 24 1110.6INS, LEP, AKT1, CRAT
41vegf448.6CDKN3, CRAT, AKT1, LEP
42creatinine448.6CRAT, AKT1, LEP, INS
43ibmx44 61 2810.5CDKN3, CRAT, AKT1, INS
44dexamethasone44 50 28 1111.5INS, LEP, AKT1, CRAT
45arginine448.5INS, LEP, AKT1, CRAT
46lipid448.2INS, LEP, AKT1, BCL10, CRAT
47testosterone44 61 24 1111.1INS, LEP, AKT1, CRAT, CDKN3
48glutamate448.1INS, LEP, AKT1, CRAT, CDKN3
49estrogen448.1INS, LEP, AKT1, CRAT, CDKN3
50serine447.7INS, LEP, AKT1, BCL10, CRAT, CDKN3

GO Terms for genes affiliated with Overnutrition

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Biological processes related to Overnutrition according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.1LEP, AGRP
2eating behaviorGO:04275510.0AGRP, LEP
3response to foodGO:0320949.9AKT1, BCL10
4response to insulinGO:0328689.9AGRP, LEP
5adipose tissue developmentGO:0606129.8LEP, FTO
6positive regulation of insulin receptor signaling pathwayGO:0466289.8INS, LEP
7positive regulation of lipid biosynthetic processGO:0468899.7AKT1, INS
8negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.7AKT1, INS
9positive regulation of cellular protein metabolic processGO:0322709.7INS, AKT1
10positive regulation of nitric-oxide synthase activityGO:0510009.7INS, AKT1
11positive regulation of glycogen biosynthetic processGO:0457259.7INS, AKT1
12negative regulation of proteolysisGO:0458619.7AKT1, INS
13cellular response to mechanical stimulusGO:0712609.6BCL10, AKT1
14positive regulation of glucose importGO:0463269.6AKT1, INS
15positive regulation of nitric oxide biosynthetic processGO:0454299.6INS, AKT1
16endocrine pancreas developmentGO:0310189.6AKT1, INS
17positive regulation of MAPK cascadeGO:0434109.6INS, LEP
18glucose transportGO:0157589.5INS, AKT1
19regulation of insulin secretionGO:0507969.4LEP, INS
20glucose metabolic processGO:0060069.3AKT1, LEP, INS
21positive regulation of cell growthGO:0303079.3INS, AKT1
22glucose homeostasisGO:0425939.1AKT1, INS

Molecular functions related to Overnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5BCL10, INS

Products for genes affiliated with Overnutrition

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Sources for Overnutrition

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet