Summaries for Overnutrition

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Wikipedia:63 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

MalaCards based summary: Overnutrition is related to obesity and glucose intolerance. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are TCR signaling in naive CD4+ T cells and HIF-1-alpha transcription factor network. The compounds alpha msh and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skeletal muscle, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Overnutrition

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Overnutrition, Aliases & Descriptions:

Name: Overnutrition 9 60


External Ids:

Disease Ontology9 DOID:654
SNOMED-CT55 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

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Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.7LEP, AKT1, AGRP, INS
2glucose intolerance30.1LEP, INS
3atherosclerosis30.0INS, LEP, AKT1, CDKN3
4breast cancer29.6CDKN3, INS, LEP, AKT1, CRAT
5thyroiditis10.5
6proteus syndrome, somatic10.5CDKN3
7acquired generalized lipodystrophy10.4LEP
8leopard syndrome10.4CDKN3
9rabson-mendenhall syndrome10.4INS
10eating disorder10.2LEP, AGRP
11anorexia nervosa10.2LEP, AGRP
12familial partial lipodystrophy10.2LEP, INS
13fetal macrosomia10.2LEP, INS
14non-suppurative otitis media10.2AGRP, LEP
15berardinelli-seip congenital lipodystrophy10.2INS, LEP
16metabolic syndrome x10.2INS, LEP
17acanthosis nigricans10.2LEP, INS
18anovulation10.2LEP, INS
19morbid obesity10.2INS, LEP
20amenorrhea10.2LEP, INS
21growth hormone deficiency10.2LEP, INS
22hypopituitarism10.2INS, LEP
23hepatitis10.2
24mody, type ii10.2LEP, INS
25hyperandrogenism10.1LEP, INS
26lipodystrophy10.1INS, LEP
27acromegaly10.1LEP, INS
28fatty liver disease10.1LEP, INS
29hypogonadism10.1LEP, INS
30tuberous sclerosis10.1CDKN3, AKT1
31prader-willi syndrome10.1INS, AGRP, LEP
32hyperthyroidism10.1LEP, INS
33hypothyroidism10.1AGRP, LEP, INS
34insulinoma10.0CRAT, INS, CDKN3
35hypertriglyceridemia10.0INS, LEP
36microvascular complications of diabetes 510.0AKT1, INS
37burns10.0
38hypervitaminosis a10.0
39cervicitis10.0
40ischemia10.0
41epididymitis10.0
42endotheliitis10.0
43coronary artery disease10.0INS, LEP, CRAT
44primary hyperoxaluria10.0INS, LEP
45familial hyperlipidemia10.0INS, LEP
46diabetes mellitus, insulin-dependent10.0LEP, CDKN3, INS
47t-cell leukemia10.0CRAT, AKT1, CDKN3
48endometrial cancer10.0CRAT, CDKN3, AKT1
49galactosemia10.0LEP, INS, CDKN3
50prostate cancer10.0AKT1, CDKN3, CRAT

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Symptoms for Overnutrition

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Drugs & Therapeutics for Overnutrition

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Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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MalaCards organs/tissues related to Overnutrition:

31
Thyroid, Heart, Skeletal muscle, Pituitary, Brain, Liver, Breast, Testes, Bone, Cerebellum, Spinal cord, Adipocyte, Kidney, Lung, Endothelial, Fetal lung

Animal Models for Overnutrition or affiliated genes

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MGI Mouse Phenotypes related to Overnutrition:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8AGRP, AKT1, LEP, INS
2MP:00107718.5FTO, AKT1, LEP, INS
3MP:00053758.4AGRP, FTO, AKT1, LEP, INS
4MP:00053698.3CRAT, AKT1, LEP, INS
5MP:00053868.3INS, LEP, AKT1, FTO, AGRP
6MP:00036318.2AGRP, BCL10, AKT1, LEP, INS
7MP:00053908.2INS, LEP, AKT1, FTO
8MP:00053878.2INS, LEP, AKT1, FTO, BCL10
9MP:00107687.9INS, LEP, AKT1, FTO, BCL10, AGRP
10MP:00053847.8INS, LEP, AKT1, BCL10, CRAT
11MP:00053787.5INS, LEP, AKT1, FTO, CRAT, AGRP
12MP:00053767.5INS, LEP, AKT1, FTO, CRAT, AGRP

Publications for Overnutrition

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Articles related to Overnutrition:

(show top 50)    (show all 183)
idTitleAuthorsYear
1
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-I^ coactivator-1I+ in rats. (25675425)
2015
2
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. (25204637)
2014
3
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. (25082159)
2014
4
Regulation of fetal lung development in response to maternal overnutrition. (24033542)
2013
5
The paradox of overnutrition in aging and cognition. (23682739)
2013
6
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. (23383303)
2013
7
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. (23900419)
2013
8
Oxidative stress programming in a rat model of postnatal early overnutrition--role of insulin resistance. (22819562)
2013
9
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. (22895107)
2013
10
Role of TRIB3 in diabetic and overnutrition-induced atherosclerosis. (22275081)
2012
11
Muscle endothelial-dependent microvascular dysfunction in adulthood due to early postnatal overnutrition. (22484032)
2012
12
Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. (22394722)
2011
13
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. (20110268)
2010
14
Symposium 1: Overnutrition: consequences and solutions. Foresight Report: the obesity challenge ahead. (19954564)
2010
15
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. (19553674)
2009
16
Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI. (18407907)
2008
17
Under- and overnutrition dynamics in Chinese children and adults (1991-2004). (17637598)
2008
18
Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. (17158475)
2007
19
Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. (17991666)
2007
20
Patterns, distribution, and determinants of under- and overnutrition: a population-based study of women in India. (16960179)
2006
21
Hypoadiponectinemia: a common basis for diseases associated with overnutrition. (16901415)
2006
22
The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. (14998807)
2004
23
Gastric inhibitory polypeptide links overnutrition to obesity. (12584208)
2003
24
Energy metabolism of young rats after early postnatal overnutrition. (12207840)
2002
25
Overnutrition and nutritional deficiency contribute to metabolic syndrome and atherosclerosis in Asian Indians. (12093466)
2002
26
Overnutrition and undernutrition as modifiers of metabolic processes in disease states. (10919956)
2000
27
Overnutrition in spiny mice (Acomys cahirinus): beta-cell expansion leading to rupture and overt diabetes on fat-rich diet and protective energy-wasting elevation in thyroid hormone on sucrose-rich diet. (10751749)
2000
28
Predicting under- and overnutrition among women of reproductive age: a population-based study in central Java, Indonesia. (10948386)
2000
29
The effect of under- and overnutrition on essential fatty acid metabolism in childhood. (9725653)
1998
30
Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions. (2156213)
1990
31
Overnutrition: an epidemic problem in pet animal practice? (2658284)
1989
32
Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. (3080654)
1986
33
Dietary-induced alterations in thyroid hormone metabolism during overnutrition. (500814)
1979
34
Overnutrition and hypervitaminosis A in the tree shrew (Lyongale tana). (96447)
1978
35
Effect of overnutrition and undernutrition on cellularity of rat epididymal fat pad. (1027950)
1976
36
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. (4826273)
1974
37
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. 3. Food consumption and weight gains. (4826268)
1974
38
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VI. The parathyroid glands and the thyroid C-cells. (4826271)
1974
39
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VII. Cervical vertebrae and spinal cord. (4826272)
1974
40
Infantile overnutrition. (4718856)
1973
41
Infantile overnutrition in the first year of life: a field study in Dudley, Worcestershire. (4642789)
1972
42
Overnutrition in West German children. (4105689)
1971
43
Behavioural responses of rats to early overnutrition. (5531295)
1970
44
UNDER-NUTRITION AND OVERNUTRITION IN TWO NEW JERSEY COMMUNITIES. (14327705)
1965
45
Some consequences of overnutrition with minerals. (13712775)
1961
46
Some psychologic considerations concerned with the problem of overnutrition. (13738289)
1961
47
The effect of age on the somatic and visceral response to overnutrition in the rat. Proc. Soc. Endocr. 60th. (13439103)
1957
48
Overnutrition for the child: blessing or curse? (13452251)
1957
49
Obesity: overnutrition or disease of metabolism? (13080244)
1953
50
Overnutrition and obesity. (12990685)
1952

Variations for Overnutrition

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Expression for genes affiliated with Overnutrition

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Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

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Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCR signaling in naive CD8+ T cells36
9.6BCL10, AKT1
29.6AKT1, LEP
39.6AKT1, LEP
49.6LEP, AKT1
5
Show member pathways
9.4INS, AKT1
69.4INS, AKT1
79.4INS, AKT1
89.4INS, AKT1
9
Show member pathways
Insulin Pathway36
9.4AKT1, INS
10
Show member pathways
9.4AKT1, INS
119.3AGRP, AKT1, LEP
129.0INS, LEP, AKT1
13
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.0INS, LEP, AKT1
14
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0AKT1, LEP, INS
15
Show member pathways
9.0AKT1, LEP, INS
16
Show member pathways
9.0AKT1, LEP, INS
17
Show member pathways
8.2CRAT, AKT1, LEP, INS

Compounds for genes affiliated with Overnutrition

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Compounds related to Overnutrition according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1alpha msh4310.1LEP, AGRP
2oxyntomodulin43 5910.9LEP, AGRP
3exenatide43 1210.8INS, LEP
4sibutramine43 1210.8INS, LEP
5pramlintide43 1210.8LEP, INS
6beta-hydroxybutyrate439.8INS, LEP
7acipimox43 2810.8INS, LEP
8ptdins(3)p439.8CDKN3, AKT1
9nash439.7INS, LEP
10intralipid439.7LEP, INS
11telmisartan43 28 1211.6INS, LEP
12cortisone43 2410.6LEP, INS
13cocaine43 1210.6AGRP, LEP, CDKN3
14orlistat43 59 1211.5INS, LEP
152-deoxyglucose43 1210.5AKT1, AGRP, INS
16inositol439.5CDKN3, LEP, AKT1
17aicar43 24 1211.4INS, AKT1, LEP
18acth439.4AGRP, INS, LEP
19metformin43 49 1211.4LEP, AKT1, INS
20troglitazone43 28 59 1212.4INS, AKT1, LEP
21ganciclovir43 1210.1LEP, CRAT, CDKN3
22gaba439.0CDKN3, CRAT, LEP
23rapamycin438.9INS, AKT1, CDKN3, LEP
24ly294002438.9INS, LEP, AKT1, CDKN3
25wortmannin438.9CDKN3, INS, AKT1, LEP
26n acetylcysteine438.8LEP, AKT1, CRAT
27etoposide43 49 59 1211.8CDKN3, CRAT, AKT1
28nmda43 289.8LEP, CDKN3, AKT1
29phosphatidylinositol438.8INS, LEP, AKT1, CDKN3
30cysteine438.7AGRP, AKT1, CDKN3, LEP
31butyrate438.7LEP, CDKN3, AKT1, CRAT
32acetylcholine43 49 28 24 1212.7CRAT, AKT1, CDKN3, LEP
33tamoxifen43 49 28 1211.7LEP, AKT1, CRAT
34fatty acid438.7AGRP, CRAT, LEP, INS
35alanine438.7CDKN3, BCL10, AKT1, INS
36cisplatin43 49 59 1211.7CRAT, AKT1, LEP, CDKN3
37cycloheximide438.6LEP, CRAT, CDKN3, AKT1
38h2o2438.6LEP, AKT1, CRAT, CDKN3
39gnrh438.6CRAT, INS, LEP, AKT1
40epinephrine43 24 1210.6INS, AKT1, LEP, CRAT
41vegf438.6AKT1, CRAT, LEP, CDKN3
42creatinine438.6CRAT, AKT1, LEP, INS
43ibmx43 59 2810.5INS, CRAT, AKT1, CDKN3
44dexamethasone43 49 28 1211.5AKT1, LEP, INS, CRAT
45arginine438.5LEP, AKT1, INS, CRAT
46lipid438.2BCL10, CRAT, AKT1, LEP, INS
47testosterone43 59 24 1211.1LEP, CDKN3, INS, CRAT, AKT1
48glutamate438.1INS, LEP, AKT1, CDKN3, CRAT
49estrogen438.1CDKN3, INS, LEP, AKT1, CRAT
50serine437.7CRAT, BCL10, INS, CDKN3, LEP, AKT1

GO Terms for genes affiliated with Overnutrition

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Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:000834310.1LEP, AGRP
2eating behaviorGO:004275510.0AGRP, LEP
3response to foodGO:00320949.9AKT1, BCL10
4response to insulinGO:00328689.9AGRP, LEP
5adipose tissue developmentGO:00606129.8LEP, FTO
6positive regulation of insulin receptor signaling pathwayGO:00466289.8INS, LEP
7positive regulation of lipid biosynthetic processGO:00468899.7AKT1, INS
8negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:019021769.7AKT1, INS
9positive regulation of cellular protein metabolic processGO:00322709.7INS, AKT1
10positive regulation of nitric-oxide synthase activityGO:00510009.7INS, AKT1
11positive regulation of glycogen biosynthetic processGO:00457259.7INS, AKT1
12negative regulation of proteolysisGO:00458619.7AKT1, INS
13cellular response to mechanical stimulusGO:00712609.6BCL10, AKT1
14positive regulation of glucose importGO:00463269.6AKT1, INS
15positive regulation of nitric oxide biosynthetic processGO:00454299.6INS, AKT1
16endocrine pancreas developmentGO:00310189.6AKT1, INS
17positive regulation of MAPK cascadeGO:00434109.6INS, LEP
18glucose transportGO:00157589.5INS, AKT1
19regulation of insulin secretionGO:00507969.4LEP, INS
20glucose metabolic processGO:00060069.3AKT1, LEP, INS
21positive regulation of cell growthGO:00303079.3INS, AKT1
22glucose homeostasisGO:00425939.1AKT1, INS

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.5BCL10, INS

Products for genes affiliated with Overnutrition

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Sources for Overnutrition

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet