MCID: OVR063
MIFTS: 50

Overnutrition malady

Categories: Metabolic diseases

Aliases & Classifications for Overnutrition

Aliases & Descriptions for Overnutrition:

Name: Overnutrition 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:654
MeSH 42 D044343
SNOMED-CT 64 302872003
UMLS 69 C1257763

Summaries for Overnutrition

MalaCards based summary : Overnutrition is related to obesity, ucp3-related and optic atrophy type 9. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Heparin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skeletal muscle, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 71 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 obesity, ucp3-related 10.4 GHRL MC4R
2 optic atrophy type 9 10.4 MC4R UCP1
3 autosomal recessive congenital ichthyosis 10.4 INS LEP PPARG
4 acrocephalopolydactyly 10.4 ADIPOQ LEP RETN
5 malignant perineurioma 10.4 ADIPOQ LEP RETN
6 hyperphosphatemia 10.4 INS LEP PPARG
7 leg dermatosis 10.4 ADIPOQ INS LEP
8 iida kannari syndrome 10.4 ADIPOQ INS PPARG
9 autoimmune disease 1 10.4 CRP INS UCP1
10 nystagmus, congenital motor, autosomal recessive 10.4 ADIPOQ LEP TNF
11 neurogenic arthropathy 10.4 ADIPOQ INS LEP
12 cataract 10.4 CRP INS TNF
13 acute infection of pinna 10.4 CRP INS
14 acquired angioedema 10.4 ADIPOQ PPARG
15 not otherwise specified 3-mga-uria type 10.4 ADIPOQ INS LEP RETN
16 cortical blindness mental retardation polydactyly 10.4 ADIPOQ LEP RETN
17 obesity 10.4
18 antidepressant type abuse 10.4 ADIPOQ INS LEP RETN
19 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.4 GHRL IL6 TNF
20 unilateral multicystic dysplastic kidney 10.4 CRP IL6 TNF
21 brain stem glioma 10.4 ADIPOQ INS LEP PPARG
22 swine influenza 10.4 CRP IL6 TNF
23 bladder sarcoma 10.4 IL6 LEP TNF
24 human immunodeficiency virus infectious disease 10.4 CRP IL6 TNF
25 breast hemangiopericytoma 10.4 CRP IL6 LEP
26 cicatricial lagophthalmos 10.4 CRP IL6 TNF
27 vulvitis 10.4 IL6 LEP SOCS3
28 luxation of globe 10.4 CRP IL6 NPY
29 benign neonatal seizures 10.3 CRP IL6 TNF
30 central nervous system leiomyoma 10.3 CRP GHRL IL6 LEP
31 chronic myocardial ischemia 10.3 CRP IL6 INS LEP
32 exophthalmic ophthalmoplegia 10.3 ADIPOQ LEP LEPR
33 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
34 neuropathy 10.3 CRP IL6 TNF
35 autoimmune disease of central nervous system 10.3 CRP IL6 TNF
36 gait apraxia 10.3 ADIPOQ CRP IL6
37 plummer's disease 10.3 CRP IL6 TNF
38 cataract 20, multiple types 10.3 ADIPOQ INS LEP PPARG RETN
39 posterior uveal melanoma 10.3 ADIPOQ CRP INS SREBF1
40 thymus clear cell carcinoma 10.3 ADIPOQ INS LEP PPARG RETN
41 pancreas lymphoma 10.3 CRP IL6 TNF
42 central nervous system lymphoma 10.3 IL6 NPY TNF
43 joint disorders 10.3 CRP IL6 INS TNF
44 atrophy of prostate 10.3 CRP IL6 TNF
45 lipomatosis 10.3 ADIPOQ CRP INS LEP PPARG
46 follicular adenoma 10.3 CRP IL6 TNF
47 carotenemia 10.3 CRP IL6 TNF
48 familial nephrotic syndrome 10.3 CRP IL6 LEP TNF
49 myiasis 10.3 CRP IL6 TNF
50 blepharochalasis 10.3 CRP IL6 TNF

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition

Symptoms & Phenotypes for Overnutrition

MGI Mouse Phenotypes related to Overnutrition:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.48 TNF UCP1 ADIPOQ AGRP CRAT CRP
2 adipose tissue MP:0005375 10.46 INS LEP LEPR MC4R NPY PPARG
3 behavior/neurological MP:0005386 10.39 ADIPOQ AGRP FTO GHRL IL6 INS
4 growth/size/body region MP:0005378 10.37 ADIPOQ AGRP CRAT FTO IL6 INS
5 cardiovascular system MP:0005385 10.28 ADIPOQ CRAT CRP IL6 INS LEP
6 liver/biliary system MP:0005370 10.25 ADIPOQ AGRP FTO IL6 INS LEP
7 immune system MP:0005387 10.23 ADIPOQ CRP FTO IL6 INS LEP
8 endocrine/exocrine gland MP:0005379 10.16 ADIPOQ FTO GHRL IL6 INS LEP
9 digestive/alimentary MP:0005381 10.13 GHRL IL6 INS LEP LEPR NPY
10 integument MP:0010771 10.09 ADIPOQ FTO IL6 INS LEP LEPR
11 nervous system MP:0003631 10 AGRP FGF1 IL6 INS LEP LEPR
12 muscle MP:0005369 9.97 ADIPOQ CRAT IL6 INS LEP LEPR
13 neoplasm MP:0002006 9.87 ADIPOQ IL6 LEP LEPR MC4R PPARG
14 normal MP:0002873 9.85 PYY SOCS3 AGRP FGF1 GHRL INS
15 renal/urinary system MP:0005367 9.56 LEP LEPR NPY PPARG ADIPOQ FTO
16 skeleton MP:0005390 9.4 MC4R NPY PPARG PYY SOCS3 TNF

Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 579)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2 9005-49-6 772 46507594
2
Aspirin Approved, Vet_approved Phase 4,Early Phase 1 50-78-2 2244
3
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
4
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
5
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
6
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
7
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
8 Moxonidine Approved Phase 4 75438-57-2 4810
9
Rocuronium Approved Phase 4,Phase 2 119302-91-9, 143558-00-3 441290
10
Glycerol Approved, Experimental Phase 4 56-81-5 753
11
Orlistat Approved, Investigational Phase 4,Phase 3,Phase 2 96829-58-2 3034010
12
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
14
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 141758-74-9 15991534
15
Saxagliptin Approved Phase 4 361442-04-8 11243969
16 Nadroparin Approved Phase 4 9041-08-1
17
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
18
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
19
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 5460373 44475014
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
21
Dalteparin Approved Phase 4,Phase 1 9041-08-1
22
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
23
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 111025-46-8 4829
24
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 58-22-0 6013
25
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
26
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
27
Ibuprofen Approved Phase 4 15687-27-1 3672
28
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
29
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2 58-93-5 3639
30
Candesartan Approved Phase 4 139481-59-7 2541
31
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
32
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
33
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
34
Galantamine Approved Phase 4 357-70-0 9651 908828, 9651
35
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2 83150-76-9 383414 6400441
36
Topiramate Approved Phase 4,Phase 3,Phase 2 97240-79-4 5284627
37
Infliximab Approved Phase 4 170277-31-3
38
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
39
Sulfamethoxazole Approved Phase 4 723-46-6 5329
40
Dapsone Approved, Investigational Phase 4 80-08-0 2955
41
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
42
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
43
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2
44
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
45
Ethambutol Approved Phase 4 74-55-5 3279 14052
46
Cefazolin Approved Phase 4 25953-19-9 656510 33255
47
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
48
Phentermine Approved, Illicit Phase 4,Phase 3,Phase 2 122-09-8 4771
49
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Early Phase 1 58-18-4 6010
50
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718

Interventional clinical trials:

(show top 50) (show all 1883)
id Name Status NCT ID Phase
1 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4
2 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4
3 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
4 The Therapeutic Effect of Catgut Embedding in Obesity Unknown status NCT02276235 Phase 4
5 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
6 Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity Unknown status NCT01970202 Phase 4
7 Pharmacokinetics of Dexmedetomidine in Morbid Obesity Unknown status NCT01864187 Phase 4
8 Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
9 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity Unknown status NCT01550601 Phase 4
10 The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity Unknown status NCT01405352 Phase 4
11 VAS Correlation With BMI Unknown status NCT02017314 Phase 4
12 Pharmacokinetics of Acetaminophen in Morbidly Obese Patients Unknown status NCT01764555 Phase 4
13 Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
14 Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
15 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4
16 Effect of Dietary and Life Style Modification on Post Liver Transplant Obesity Unknown status NCT00878592 Phase 4
17 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Unknown status NCT00288873 Phase 4
18 Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4
19 Vitamin Deficiencies and Suppletion in Morbid Obesity Unknown status NCT02270749 Phase 4
20 The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension Unknown status NCT01360710 Phase 4
21 Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients Unknown status NCT00871845 Phase 4
22 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4
23 Prophylaxis of Venous Thromboembolism After Bariatric Surgery Unknown status NCT02295150 Phase 4
24 CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug Unknown status NCT01519726 Phase 4
25 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed NCT01090141 Phase 4
26 Bread in Overweight/Obesity Treatment Completed NCT01223989 Phase 4
27 A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents Completed NCT02714062 Phase 4
28 Use of Metformin in Treatment of Childhood Obesity Completed NCT02274948 Phase 4
29 Auricular Acupuncture in the Treatment of Obesity Completed NCT02269371 Phase 4
30 GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men Completed NCT02170324 Phase 4
31 Increased Cefazolin During Cesarean Delivery in Obese Population Completed NCT02049944 Phase 4
32 Enoxaparin Dosing in Obesity Completed NCT01798550 Phase 4
33 Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention Completed NCT01757925 Phase 4
34 Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity Completed NCT01639677 Phase 4
35 Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations Completed NCT01307930 Phase 4
36 A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women Completed NCT01206413 Phase 4
37 Fondaparinux Population Pharmacokinetic to Morbid Obese Patients in Post-operatory Bariatric Surgery Completed NCT01064596 Phase 4
38 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed NCT01062165 Phase 4
39 Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs) Completed NCT00694811 Phase 4
40 Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band Completed NCT00543140 Phase 4
41 A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients Completed NCT00171613 Phase 4
42 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4
43 The Effect of Xenical on Weight and Risk Factors Completed NCT00152360 Phase 4
44 Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery Completed NCT02778958 Phase 4
45 Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass Completed NCT02340247 Phase 4
46 Anidulafungin Pharmacokinetics Given as a Single Intravenous Dose to Obese Patients (ADOPT) Completed NCT02021123 Phase 4
47 Pharmacokinetics of Propofol in Morbidly Obese Patients Completed NCT01536002 Phase 4
48 Population PK/PD of Propofol in the Morbidly Obese Patient Completed NCT00395681 Phase 4
49 Investigations on the Influence of Bariatric Surgery on the Metabolism and Absorption of Atorvastatin Completed NCT00331565 Phase 4
50 Low Dose Liraglutide and Metformin vs. High Dose Liraglutide Alone in Treatment of Obesity Completed NCT02909933 Phase 4

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Genetic Tests for Overnutrition

Anatomical Context for Overnutrition

MalaCards organs/tissues related to Overnutrition:

39
Thyroid, Heart, Skeletal Muscle, Pituitary, Bone, Liver, Breast

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 202)
id Title Authors Year
1
Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )
2017
2
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )
2016
3
From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century. ( 27544200 )
2016
4
Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. ( 27701408 )
2016
5
Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )
2016
6
Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats. ( 27469432 )
2016
7
Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. ( 27195103 )
2016
8
Overnutrition, ectopic lipid and the metabolic syndrome. ( 27194746 )
2016
9
Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. ( 26690419 )
2015
10
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. ( 25685686 )
2015
11
Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. ( 25835281 )
2015
12
Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. ( 26203167 )
2015
13
Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. ( 25504042 )
2015
14
The double burden of under- and overnutrition and nutrient adequacy among Chinese preschool and school-aged children in 2009-2011. ( 26130296 )
2015
15
Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. ( 26497334 )
2015
16
Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats. ( 26302954 )
2015
17
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. ( 26407845 )
2015
18
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-I^ coactivator-1I+ in rats. ( 25675425 )
2015
19
The changing context of overnutrition and undernutrition in Pakistan. ( 25794668 )
2015
20
The Double Burden of Undernutrition and Overnutrition in Developing Countries: an Update. ( 26627492 )
2015
21
Association of Vitamin A Status with Overnutrition in Children and Adolescents. ( 26690192 )
2015
22
FGF1 Mediates Overnutrition-Induced Compensatory I^-Cell Differentiation. ( 26420862 )
2015
23
Impact of maternal overnutrition on the periconceptional period. ( 25733194 )
2015
24
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. ( 25204637 )
2014
25
Impact of maternal overnutrition on gluconeogenic factors and methylation of the phosphoenolpyruvate carboxykinase promoter in the fetal and postnatal liver. ( 24452591 )
2014
26
Overnutrition induces I^-cell differentiation through prolonged activation of I^-cells in zebrafish larvae. ( 24473439 )
2014
27
Childhood dual burden of under- and overnutrition in low- and middle-income countries: a critical review. ( 25076771 )
2014
28
Multi-generational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters. ( 25354845 )
2014
29
Shifting of undernutrition to overnutrition and its determinants among women of reproductive ages in the 36 low to medium income countries. ( 24925607 )
2014
30
Maternal overnutrition enhances mRNA expression of adipogenic markers and collagen deposition in skeletal muscle of beef cattle fetuses. ( 25006073 )
2014
31
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. ( 25082159 )
2014
32
Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. ( 25673017 )
2014
33
Overnutrition, mTOR signaling, and cardiovascular diseases. ( 25253086 )
2014
34
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. ( 22895107 )
2013
35
Association between insulin-like growth factor-1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north-west province, South Africa. ( 24375890 )
2013
36
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. ( 23900419 )
2013
37
Regulation of fetal lung development in response to maternal overnutrition. ( 24033542 )
2013
38
Maternal Overnutrition Program Changes in Skeletal Muscle Gene Expression Associated with Insulin Resistance and Reduction in Oxidative Phosphorylation Enzymes in Adult Male Rat Offspring. ( 24381224 )
2013
39
Overnutrition and associated factors among adults aged 20 years and above in fishing communities in the urban Cape Coast Metropolis, Ghana. ( 22643132 )
2013
40
Identification of a novel interorgan mechanism favoring energy storage in overnutrition. ( 24052907 )
2013
41
Postnatal early overnutrition causes long-term renal decline in aging male rats. ( 24232634 )
2013
42
Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations. ( 23959078 )
2013
43
Double burden of undernutrition and overnutrition in Vietnam in 2011: results of the SEANUTS study in 0A^5-11-year-old children. ( 24016766 )
2013
44
Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats. ( 24223863 )
2013
45
Role of developmental overnutrition in pediatric obesity and type 2 diabetes. ( 24147926 )
2013
46
Neuroinflammation in overnutrition-induced diseases. ( 23374717 )
2013
47
Overnutrition stimulates intestinal epithelium proliferation through I^-catenin signaling in obese mice. ( 23884889 )
2013
48
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. ( 23383303 )
2013
49
Pre-natal undernutrition and post-natal overnutrition are associated with permanent changes in hepatic metabolism markers and fatty acid composition in sheep. ( 24313944 )
2013
50
Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep. ( 23287634 )
2013

Variations for Overnutrition

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for Overnutrition

Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 ADIPOQ IL6 INS LEP LEPR PPARG
2
Show member pathways
12.71 ADIPOQ IL6 INS LEP RETN SOCS3
3 12.44 ADIPOQ FTO INS PPARG SREBF1 UCP1
4
Show member pathways
12.33 ADIPOQ INS LEP LEPR PPARG SREBF1
5
Show member pathways
12.24 CRP IL6 INS TNF
7
Show member pathways
12.11 IL6 LEP LEPR SOCS3
8
Show member pathways
11.84 IL6 INS SOCS3 SREBF1 TNF
9
Show member pathways
11.82 ADIPOQ INS SOCS3 TNF
10
Show member pathways
11.73 CRP IL6 SOCS3
11 11.72 ADIPOQ IL6 INS LEP PPARG UCP1
12 11.66 INS PPARG SREBF1
13 11.64 ADIPOQ PPARG UCP1
14 11.57 FGF1 IL6 TNF
15 11.5 IL6 INS SOCS3
16 11.46 INS LEP LEPR SOCS3
17 11.44 ADIPOQ IL6 INS LEP PPARG RETN
18 11.42 FGF1 IL6 INS
19 11.34 ADIPOQ AGRP LEP LEPR NPY SOCS3
20 11.28 IL6 SOCS3 TNF
21
Show member pathways
11.15 CRP LEP LEPR SOCS3
22 11.12 ADIPOQ LEP PPARG
23 10.98 CRP IL6 TNF
24 10.9 ADIPOQ IL6 LEP PPARG TNF
25 10.5 FTO UCP1

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ADIPOQ AGRP CRP FGF1 GHRL IL6
2 extracellular space GO:0005615 9.4 ADIPOQ AGRP CRP FGF1 GHRL IL6

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 ADIPOQ IL6 INS
2 cholesterol metabolic process GO:0008203 9.88 LEP LEPR SREBF1
3 positive regulation of MAPK cascade GO:0043410 9.88 IL6 INS LEP
4 cellular response to insulin stimulus GO:0032869 9.88 ADIPOQ PPARG SREBF1
5 response to nutrient GO:0007584 9.87 ADIPOQ LEP PPARG
6 negative regulation of inflammatory response GO:0050728 9.87 ADIPOQ GHRL SOCS3
7 response to glucocorticoid GO:0051384 9.85 ADIPOQ IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
9 regulation of blood pressure GO:0008217 9.85 LEP NPY PPARG
10 regulation of insulin secretion GO:0050796 9.85 LEP SREBF1 TNF
11 circadian rhythm GO:0007623 9.84 ADIPOQ AGRP LEP SREBF1
12 response to mechanical stimulus GO:0009612 9.83 IL6 PPARG RETN
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL6 RETN TNF
14 positive regulation of protein kinase B signaling GO:0051897 9.83 IL6 INS LEP TNF
15 negative regulation of fat cell differentiation GO:0045599 9.79 ADIPOQ IL6 TNF
16 response to cold GO:0009409 9.78 IL6 PPARG UCP1
17 response to nutrient levels GO:0031667 9.78 ADIPOQ IL6 LEP UCP1
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL6 INS TNF
19 response to insulin GO:0032868 9.77 AGRP IL6 LEP MC4R RETN
20 acute-phase response GO:0006953 9.76 CRP IL6 INS
21 feeding behavior GO:0007631 9.76 AGRP MC4R NPY PYY
22 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.75 IL6 LEP SOCS3
23 eating behavior GO:0042755 9.73 AGRP LEP PYY
24 glucose metabolic process GO:0006006 9.72 ADIPOQ GHRL INS LEP TNF
25 central nervous system neuron development GO:0021954 9.71 LEP NPY
26 positive regulation of insulin receptor signaling pathway GO:0046628 9.71 INS LEP
27 negative regulation of glucose import GO:0046325 9.7 LEP TNF
28 negative regulation of hormone secretion GO:0046888 9.69 ADIPOQ IL6
29 sexual reproduction GO:0019953 9.69 LEP LEPR
30 energy reserve metabolic process GO:0006112 9.69 LEP LEPR MC4R
31 response to caffeine GO:0031000 9.68 IL6 PPARG
32 regulation of appetite GO:0032098 9.68 NPY PYY
33 leptin-mediated signaling pathway GO:0033210 9.67 LEP LEPR
34 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ADIPOQ CRP PPARG
35 diet induced thermogenesis GO:0002024 9.66 MC4R UCP1
36 negative regulation of acute inflammatory response GO:0002674 9.65 INS PPARG
37 negative regulation of collagen biosynthetic process GO:0032966 9.65 IL6 PPARG
38 negative regulation of vasodilation GO:0045908 9.64 CRP INS
39 regulation of bone remodeling GO:0046850 9.64 LEP LEPR
40 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.63 IL6 TNF
41 regulation of brown fat cell differentiation GO:0090335 9.63 FTO LEP
42 glucose homeostasis GO:0042593 9.63 ADIPOQ IL6 INS LEP LEPR PPARG
43 positive regulation of cholesterol biosynthetic process GO:0045542 9.62 FGF1 SREBF1
44 regulation of metabolic process GO:0019222 9.62 LEP MC4R
45 regulation of feeding behavior GO:0060259 9.61 AGRP LEPR MC4R
46 positive regulation of appetite GO:0032100 9.59 GHRL NPY
47 negative regulation of feeding behavior GO:2000252 9.58 INS MC4R RETN
48 positive regulation of STAT protein import into nucleus GO:2000366 9.57 IL6 LEP
49 negative regulation of gluconeogenesis GO:0045721 9.56 ADIPOQ IL6 INS LEPR
50 bone growth GO:0098868 9.55 LEP LEPR

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor binding GO:0001664 9.43 GHRL NPY PYY
2 receptor binding GO:0005102 9.43 ADIPOQ AGRP CRAT IL6 LEP NPY
3 neuropeptide hormone activity GO:0005184 9.33 AGRP NPY PYY
4 hormone activity GO:0005179 9.17 ADIPOQ GHRL INS LEP NPY PYY

Sources for Overnutrition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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