MCID: OVR063
MIFTS: 44

Overnutrition malady

Summaries for Overnutrition

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63Wikipedia, 32MalaCards
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Wikipedia:63 Overnutrition is a form of malnutrition in which nutrients are oversupplied relative to the amounts... more...

MalaCards: Overnutrition is related to obesity and atherosclerosis. An important gene associated with Overnutrition is AGRP (agouti related protein homolog (mouse)), and among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development Leptin signaling via PI3K-dependent pathway. The compounds fatty acid and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Aliases & Classifications for Overnutrition

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

overnutrition 8 60


External Ids:

Disease Ontology8 DOID:654
SNOMED-CT56 190943006
ICD9CM27 277.6

Related Diseases for Overnutrition

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Overnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9AKT1, AGRP, INS, LEP
2atherosclerosis30.2AKT1, CDKN3, INS, LEP
3ischemia29.9AKT1, CDKN3
4gestational diabetes29.9INS, LEP
5thyroiditis10.4
6breast cancer10.1
7hepatitis10.1
8narcolepsy10.0LEP
9acquired generalized lipodystrophy10.0LEP
10proteus syndrome10.0CDKN3
11osteoarthritis10.0CDKN3
12leopard syndrome10.0CDKN3
13cowden disease10.0CDKN3
14adenocarcinoma10.0AKT1
15hepatitis b10.0CRAT
16neuroblastoma10.0AKT1
17pancreatitis10.0INS
18rabson-mendenhall syndrome10.0INS
19cushing's syndrome10.0INS
20multiple myeloma10.0AKT1
21hepatoblastoma10.0CRAT
22anorexia nervosa10.0AGRP, LEP
23myeloma10.0CDKN3, AKT1
24thyroid cancer10.0CDKN3, AKT1
25tuberculosis10.0CRAT, CDKN3
26tuberous sclerosis10.0AKT1, CDKN3
27eating disorder10.0LEP, AGRP
28colon cancer10.0AKT1, CDKN3
29arthritis10.0CDKN3, LEP
30choriocarcinoma10.0LEP, CRAT
31liver cirrhosis10.0LEP
32thyrotoxicosis10.0INS
33rhabdomyosarcoma10.0AKT1, CRAT
34familial partial lipodystrophy10.0LEP, INS
35fetal macrosomia10.0INS, LEP
36congenital generalized lipodystrophy type 210.0LEP, INS
37ovarian cancer10.0CDKN3, AKT1
38hypoglycemia10.0INS, CDKN3
39morbid obesity10.0INS, LEP
40metabolic syndrome x10.0LEP, INS
41myopathy10.0CRAT, INS
42anovulation10.0INS, LEP
43acanthosis nigricans10.0INS, LEP
44fatty liver disease10.0LEP, INS
45bronchitis10.0LEP, AGRP
46schizophrenia10.0INS, AKT1
47polycystic ovary syndrome10.0LEP, INS
48diabetic retinopathy10.0AKT1, INS
49colorectal cancer10.0AKT1, BCL10
50t-cell leukemia10.0CDKN3, AKT1, CRAT

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to overnutrition

Clinical Features for Overnutrition

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Drugs & Therapeutics for Overnutrition

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Overnutrition

Search NIH Clinical Center for Overnutrition

Search CenterWatch for Overnutrition

Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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32MalaCards
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MalaCards organs/tissues related to Overnutrition:

32
Thyroid, Heart, Pituitary, Skeletal muscle, Breast, Testes, Brain, Lung, Bone, Endothelial, Liver, Spinal cord, Adipocyte, Kidney, Cerebellum, Fetal lung

Animal Models for Overnutrition or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Overnutrition:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.6AGRP, FTO
2MP:00053767.8LEP, FTO, AGRP, AKT1, CRAT, INS
3MP:00053787.5LEP, CRAT, AKT1, AGRP, FTO, INS

Publications for Overnutrition

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Sources:
50PubMed
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Articles related to Overnutrition:

(show top 50)    (show all 169)
idTitleAuthorsYear
1
Regulation of fetal lung development in response to maternal overnutrition. (24033542)
2013
2
The paradox of overnutrition in aging and cognition. (23682739)
2013
3
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. (22895107)
2013
4
Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents. (24337156)
2013
5
Maternal Overnutrition Program Changes in Skeletal Muscle Gene Expression Associated with Insulin Resistance and Reduction in Oxidative Phosphorylation Enzymes in Adult Male Rat Offspring. (24381224)
2013
6
Precursors to overnutrition: the effects of household market food expenditures on measures of body composition among Tsimane' adults in lowland Bolivia. (23849279)
2013
7
Double burden of undernutrition and overnutrition in Vietnam in 2011: results of the SEANUTS study in 0A^5-11-year-old children. (24016766)
2013
8
Devastating metabolic consequences of a life of plenty: focus on the dyslipidemia of overnutrition. (24088328)
2013
9
The impact of maternal overnutrition and obesity on hypothalamic-pituitary-adrenal axis response of offspring to stress. (22264661)
2012
10
Impact of maternal periconceptional overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb. (20861234)
2010
11
Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development. (20576133)
2010
12
Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet. (20403085)
2010
13
Symposium 1: Overnutrition: consequences and solutions. Obesity and cancer risk. (19954565)
2010
14
mTOR function in skeletal muscle: a focal point for overnutrition and exercise. (19935842)
2009
15
Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI. (18407907)
2008
16
Maternal overnutrition suppresses the phosphorylation of 5'-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep. (18784329)
2008
17
Early overnutrition impairs insulin signaling in the heart of adult Swiss mice. (18599621)
2008
18
Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. (17158475)
2007
19
Programmed metabolic syndrome: prenatal undernutrition and postweaning overnutrition. (17898113)
2007
20
The role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: thyroid hormone as an antioxidant. (17023119)
2007
21
The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. (14998807)
2004
22
Under- and overnutrition: a global perspective. (15361675)
2004
23
Nutritional status of 11-12-year-old Jamaican children: coexistence of under- and overnutrition in early adolescence. (12020379)
2002
24
Predicting under- and overnutrition among women of reproductive age: a population-based study in central Java, Indonesia. (10948386)
2000
25
Carcinogens in the diet vs. overnutrition. Individual dietary habits, malnutrition, and genetic susceptibility modify carcinogenic potency and cancer risk. (10415443)
1999
26
The effect of under- and overnutrition on essential fatty acid metabolism in childhood. (9725653)
1998
27
Effects of under- and overnutrition on lactation in laboratory rats. (9478033)
1998
28
The effect of experimental overnutrition on nonshivering thermogenesis and obesity in LA/N-cp rats. (1674462)
1991
29
Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions. (2156213)
1990
30
Influence of early postnatal overnutrition of rats on fatty acid composition of membrane lipids. (2628754)
1989
31
Thyroxine-binding prealbumin, overnutrition and apolipoprotein A1. (2429942)
1986
32
Childhood overnutrition predisposes to the later development of breast cancer: an hypothesis. (4046898)
1985
33
Breast cancer in relation to overnutrition. (7382328)
1980
34
Does overnutrition or obesity during the first year affect weight at age four? (676732)
1978
35
The consequences of early overnutrition for fat cell size and number: the pig as an experimental model for human obesity. (617328)
1977
36
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. (4826273)
1974
37
Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. VI. The parathyroid glands and the thyroid C-cells. (4826271)
1974
38
Overnutrition, overgrowth and hormones (with special reference to the infant born of the diabetic mother). (4611169)
1974
39
Infantile overnutrition. (4718856)
1973
40
Influence of protein under- and overnutrition on spontaneous tumor prevalence in the rat. (4351915)
1973
41
The effect of early undernutrition and overnutrition on thyroid gland function in rats. (4778777)
1973
42
Infantile overnutrition. (4714475)
1973
43
Infantile overnutrition. (4646851)
1972
44
Infantile overnutrition among artificially fed infants in the Sheffield region. (5541724)
1971
45
Behavioural responses of rats to early overnutrition. (5531295)
1970
46
Hypervitaminosis and overnutrition. Effects of intakes above essential allowances. (13993585)
1963
47
Some consequences of overnutrition with minerals. (13712775)
1961
48
Overnutrition in the infant and child. (13810821)
1960
49
Overnutrition and undernutrition. II. Effects. (13098065)
1953
50
Overnutrition and obesity. (12990685)
1952

Genetic Variations for Overnutrition

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Expression for genes affiliated with Overnutrition

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for genes affiliated with Overnutrition

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52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Overnutrition

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Overnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fatty acid4410.5AGRP
2alpha msh4410.1AGRP, LEP
3oxyntomodulin44 5911.1LEP, AGRP
4exenatide44 1111.0LEP, INS
5gnrh4410.0CRAT, AKT1
6pramlintide44 1111.0INS, LEP
7sibutramine44 1111.0INS, LEP
8beta-hydroxybutyrate449.9LEP, INS
9acipimox44 2810.9LEP, INS
10intralipid449.9INS, LEP
11nash449.9INS, LEP
12telmisartan44 28 1111.9LEP, INS
13cortisone44 2410.9LEP, INS
14orlistat44 59 1111.9INS, LEP
15thiazolidinedione449.7LEP, INS
162-deoxyglucose44 1110.6INS, AGRP, AKT1
17aicar44 11 2411.6LEP, INS, AKT1
18metformin44 49 1111.6AKT1, INS, LEP
19ptdins(3)p449.6AKT1, CDKN3
20acth449.6AGRP, INS, LEP
21troglitazone44 28 59 1112.6LEP, INS, AKT1
22indole-3-carbinol449.5AKT1, CRAT
238-isoprostane449.5LEP, INS
24n acetylcysteine449.3CRAT, AKT1, LEP
25cocaine44 1110.3AGRP, CDKN3, LEP
26dexamethasone44 49 28 1112.3CRAT, AKT1, INS
27inositol449.3LEP, CDKN3, AKT1
28tamoxifen44 49 28 1112.2LEP, AKT1, CRAT
29ganciclovir44 1110.2LEP, CDKN3, CRAT
30serine449.1BCL10, LEP, CDKN3
31epinephrine44 11 2411.1LEP, INS, AKT1, CRAT
32creatinine449.1CRAT, AKT1, INS, LEP
33gaba449.0LEP, CDKN3, CRAT
34etoposide44 49 59 1111.9CDKN3, AKT1, CRAT
35arginine448.9CRAT, AKT1, INS, LEP
36nmda44 289.9AKT1, CDKN3, LEP
37butyrate448.8CRAT, AKT1, CDKN3, LEP
38acetylcholine44 49 28 11 2412.8CRAT, AKT1, CDKN3, LEP
39rapamycin448.8LEP, INS, CDKN3, AKT1
40ly294002448.8AKT1, CDKN3, INS, LEP
41wortmannin448.8AKT1, CDKN3, INS, LEP
42norepinephrine44 11 2410.8LEP, INS, CRAT
43cisplatin44 49 59 1111.8CRAT, AKT1, CDKN3, LEP
44h2o2448.7CRAT, AKT1, CDKN3, LEP
45ibmx44 28 5910.7INS, CDKN3, AKT1, CRAT
46vegf448.6LEP, CDKN3, AKT1, CRAT
47phosphatidylinositol448.6AKT1, CDKN3, INS, LEP
48lipid448.4CRAT, AKT1, INS, LEP, BCL10
49testosterone44 59 11 2411.3CRAT, AKT1, CDKN3, INS, LEP
50alanine448.2AKT1, CDKN3, INS, BCL10

GO Terms for genes affiliated with Overnutrition

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16Gene Ontology
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Biological processes related to Overnutrition according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1adult feeding behaviorGO:00834310.0LEP, AGRP
2positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
3positive regulation of lipid biosynthetic processGO:0468899.8INS, AKT1
4negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.8INS, AKT1
5positive regulation of cellular protein metabolic processGO:0322709.7INS, AKT1
6adipose tissue developmentGO:0606129.7FTO, LEP
7positive regulation of nitric-oxide synthase activityGO:0510009.7AKT1, INS
8positive regulation of glycogen biosynthetic processGO:0457259.7INS, AKT1
9negative regulation of proteolysisGO:0458619.5AKT1, INS
10endocrine pancreas developmentGO:0310189.5INS, AKT1
11positive regulation of glucose importGO:0463269.4INS, AKT1
12glucose metabolic processGO:0060069.4AKT1, INS, LEP
13positive regulation of nitric oxide biosynthetic processGO:0454299.2INS, AKT1

Products for genes affiliated with Overnutrition

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Sources for Overnutrition

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet