MCID: OVR063
MIFTS: 53

Overnutrition

Categories: Metabolic diseases

Aliases & Classifications for Overnutrition

MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:654
MeSH 41 D044343
SNOMED-CT 64 302872003
UMLS 69 C1257763

Summaries for Overnutrition

MalaCards based summary : Overnutrition is related to nutritional deficiency disease and body mass index quantitative trait locus 14. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Heparin and Zinc have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 72 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 nutritional deficiency disease 32.3 CRP GHRL IL6 LEP
2 body mass index quantitative trait locus 14 31.7 FTO MC4R
3 gestational diabetes 30.8 ADIPOQ INS LEP RETN
4 glucose intolerance 30.0 ADIPOQ CRP GHRL INS LEP LEPR
5 body mass index quantitative trait locus 11 29.7 ADIPOQ AGRP CRP FTO GHRL IL6
6 acquired generalized lipodystrophy 10.7 ADIPOQ LEP RETN
7 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.7 CRP INS LEP
8 familial partial lipodystrophy 10.7 INS LEP PPARG
9 idiopathic recurrent pericarditis 10.7 ADIPOQ LEP RETN
10 endocrine pancreas disease 10.7 ADIPOQ INS LEP
11 malignant otitis externa 10.7 CRP INS
12 idiopathic edema 10.7 ADIPOQ INS PPARG
13 acanthosis nigricans 10.7 ADIPOQ INS LEP
14 nontuberculous mycobacterial lung disease 10.7 ADIPOQ LEP TNF
15 coronary artery aneurysm 10.7 ADIPOQ LEP RETN
16 acute insulin response 10.7 CRP INS UCP1
17 achromatopsia 3 10.7 AGRP MC4R TRPV1
18 lutheran suppressor, x-linked 10.7 ADIPOQ INS LEP RETN
19 scorpion envenomation 10.6 IL6 TNF
20 lipodystrophy 10.6 ADIPOQ INS LEP PPARG
21 3-hydroxyacyl-coa dehydrogenase deficiency 10.6 ADIPOQ GHRL INS PPARG
22 inherited metabolic disorder 10.6 ADIPOQ CRP INS LEP
23 diabetic foot ulcers 10.6 CRP IL6 LEPR
24 cold agglutinin disease 10.6 CRP IL6
25 hyperglycemia 10.6 ADIPOQ INS LEP PPARG
26 severe pre-eclampsia 10.6 ADIPOQ LEP LEPR
27 burning mouth syndrome 10.6 IL6 TNF TRPV1
28 coronary heart disease 1 10.6 ADIPOQ CRP INS
29 protein-energy malnutrition 10.6 IL6 LEP TNF
30 pulpitis 10.6 IL6 TNF TRPV1
31 sleep disorder 10.6 CRP IL6 LEP
32 rosacea 10.6 IL6 TNF TRPV1
33 uremia 10.6 CRP INS LEP RETN
34 lacrimal apparatus disease 10.6 IL6 TNF TRPV1
35 obesity-hypoventilation syndrome 10.6 ADIPOQ IL6 LEP RETN
36 bladder disease 10.6 CRP IL6 TRPV1
37 intermittent explosive disorder 10.6 CRP IL6 NPY
38 central nervous system vasculitis 10.6 CRP IL6 TNF
39 louse-borne relapsing fever 10.6 CRP IL6 TNF
40 ischemic heart disease 10.6 CRP IL6 TNF
41 bulimia nervosa 1 10.6 GHRL LEP MC4R NPY
42 extrinsic cardiomyopathy 10.6 IL6 TNF TNNI3K
43 adult-onset still's disease 10.6 CRP IL6 TNF
44 perinatal necrotizing enterocolitis 10.6 CRP IL6 TNF
45 chronic kidney failure 10.6 CRP IL6 INS LEP
46 abdominal obesity-metabolic syndrome 1 10.6 ADIPOQ GHRL INS LEP PPARG
47 lymph node disease 10.6 CRP IL6 TNF
48 infective endocarditis 10.6 CRP IL6 TNF
49 hemorrhagic fever with renal syndrome 10.6 CRP IL6 TNF
50 female reproductive system disease 10.6 IL6 INS TNF TRPV1

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition

Symptoms & Phenotypes for Overnutrition

MGI Mouse Phenotypes related to Overnutrition:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.49 LEP INS LEPR PPARG MC4R RETN
2 adipose tissue MP:0005375 10.48 LEP INS LEPR PPARG MC4R RETN
3 behavior/neurological MP:0005386 10.41 LEP INS LEPR PPARG MC4R NPY
4 growth/size/body region MP:0005378 10.39 LEP INS LEPR PPARG MC4R NPY
5 cardiovascular system MP:0005385 10.37 LEP INS LEPR PPARG MC4R SOCS3
6 cellular MP:0005384 10.29 INS IL6 LEP LEPR PPARG SOCS3
7 immune system MP:0005387 10.29 LEP INS LEPR SOCS3 PPARG MC4R
8 liver/biliary system MP:0005370 10.28 LEP INS LEPR PPARG MC4R RETN
9 endocrine/exocrine gland MP:0005379 10.18 IL6 LEP INS LEPR PPARG TNF
10 integument MP:0010771 10.16 IL6 LEP INS LEPR SOCS3 PPARG
11 digestive/alimentary MP:0005381 10.14 LEPR IL6 LEP INS NPY SOCS3
12 nervous system MP:0003631 10.06 IL6 LEP INS NPY LEPR PPARG
13 muscle MP:0005369 10.01 LEPR IL6 LEP INS PPARG TNF
14 neoplasm MP:0002006 9.97 IL6 LEP LEPR PPARG MC4R TRPV1
15 normal MP:0002873 9.81 LEPR INS PPARG MC4R NPY SOCS3
16 no phenotypic analysis MP:0003012 9.8 INS LEPR PPARG MC4R TRPV1 TNF
17 renal/urinary system MP:0005367 9.61 IL6 LEP INS LEPR PPARG NPY
18 skeleton MP:0005390 9.36 IL6 LEP INS LEPR SOCS3 PPARG

Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 594)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2 9005-49-6 46507594 772
2
Zinc Approved, Investigational Phase 4,Phase 2,Early Phase 1 7440-66-6 32051 23994
3
Aspirin Approved, Vet_approved Phase 4,Early Phase 1 50-78-2 2244
4
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
5
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
6
Acetaminophen Approved Phase 4,Phase 3,Phase 1,Early Phase 1 103-90-2 1983
7
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 4091 14219
8
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
9
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
10
Rocuronium Approved Phase 4,Phase 2 119302-91-9, 143558-00-3 441290
11
Glycerol Approved, Investigational Phase 4 56-81-5 753
12
Orlistat Approved, Investigational Phase 4,Phase 3,Phase 2 96829-58-2 3034010
13
Clozapine Approved Phase 4 5786-21-0 2818
14
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
15
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
16
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 2078-54-8 4943
17
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 141758-74-9 15991534
18
Saxagliptin Approved Phase 4 361442-04-8 11243969
19 Nadroparin Approved, Investigational Phase 4 9041-08-1
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
21
Menthol Approved Phase 4,Phase 2,Early Phase 1 2216-51-5 16666
22
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 5460373 44475014 11953898
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
24
Methylene blue Approved, Investigational Phase 4,Phase 1,Phase 2 61-73-4
25
Dalteparin Approved Phase 4,Phase 1 9005-49-6
26
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
27
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 111025-46-8 4829
28
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 58-22-0 6013
29
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
30
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
31
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
32
Ibuprofen Approved Phase 4 15687-27-1 3672
33
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
34
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2 58-93-5 3639
35
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
36
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
37
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
38
Galantamine Approved Phase 4 357-70-0 9651
39
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2 83150-76-9 6400441 383414
40
Topiramate Approved Phase 4,Phase 3,Phase 2 97240-79-4 5284627
41
Infliximab Approved Phase 4 170277-31-3
42
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
43
Sulfamethoxazole Approved Phase 4 723-46-6 5329
44
Dapsone Approved, Investigational Phase 4 80-08-0 2955
45
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
46
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
47
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
48
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
49
Ethambutol Approved Phase 4 74-55-5 14052 3279
50 Fondaparinux Approved, Investigational Phase 4,Phase 1 104993-28-4

Interventional clinical trials:

(show top 50) (show all 2112)

# Name Status NCT ID Phase Drugs
1 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
2 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
3 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
4 The Therapeutic Effect of Catgut Embedding in Obesity Unknown status NCT02276235 Phase 4
5 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
6 Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity Unknown status NCT01970202 Phase 4 40mg Enoxaparin;60mg Enoxaparin
7 Pharmacokinetics of Dexmedetomidine in Morbid Obesity Unknown status NCT01864187 Phase 4 Dexmedetomidine
8 Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
9 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity Unknown status NCT01550601 Phase 4
10 The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity Unknown status NCT01405352 Phase 4
11 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
12 VAS Correlation With BMI Unknown status NCT02017314 Phase 4 Morphine
13 Pharmacokinetics of Acetaminophen in Morbidly Obese Patients Unknown status NCT01764555 Phase 4 acetaminophen 2 g
14 Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
15 Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
16 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
17 The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine Unknown status NCT01654640 Phase 4 Metformin;Placebo (for metformin)
18 Vitamin Deficiencies and Suppletion in Morbid Obesity Unknown status NCT02270749 Phase 4 Hydroxocobalamin;FitForMe vitamin B12
19 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Unknown status NCT00288873 Phase 4 Ergocalciferol;Cholecalciferol
20 Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4 Metformin
21 The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension Unknown status NCT01360710 Phase 4 Moxonidine;Irbesartan
22 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
23 Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients Unknown status NCT00871845 Phase 4 Orlistat
24 Prophylaxis of Venous Thromboembolism After Bariatric Surgery Unknown status NCT02295150 Phase 4 Nadroparin
25 CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug Unknown status NCT01519726 Phase 4 Midazolam
26 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed NCT01090141 Phase 4 Micafungin;Micafungin
27 Bread in Overweight/Obesity Treatment Completed NCT01223989 Phase 4
28 BIFI-OBESE: Clinical Trial in Paediatric Obesity Completed NCT03261466 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
29 A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents Completed NCT02714062 Phase 4 Placebo;VI-0521 Mid Dose;VI-0521 Top Dose
30 Use of Metformin in Treatment of Childhood Obesity Completed NCT02274948 Phase 4 Metformin;Placebo
31 Auricular Acupuncture in the Treatment of Obesity Completed NCT02269371 Phase 4
32 GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men Completed NCT02170324 Phase 4 Exenatide;Placebo
33 Increased Cefazolin During Cesarean Delivery in Obese Population Completed NCT02049944 Phase 4 Cefazolin
34 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
35 Enoxaparin Dosing in Obesity Completed NCT01798550 Phase 4 Enoxaparin
36 Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention Completed NCT01757925 Phase 4
37 Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity Completed NCT01639677 Phase 4
38 Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations Completed NCT01307930 Phase 4 Anidulafungin
39 A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women Completed NCT01206413 Phase 4
40 Fondaparinux Population Pharmacokinetic to Morbid Obese Patients in Post-operatory Bariatric Surgery Completed NCT01064596 Phase 4
41 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed NCT01062165 Phase 4 Caspofungin
42 Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs) Completed NCT00694811 Phase 4
43 Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band Completed NCT00543140 Phase 4
44 A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients Completed NCT00171613 Phase 4 Octreotide
45 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4 Sandostatin LAR
46 Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia Completed NCT03358524 Phase 4 Vitamin E 400 UNT;Placebo oral capsule
47 Micafungin Pharmacokinetics in Obese Patients Completed NCT03102658 Phase 4 Micafungin
48 Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery Completed NCT02778958 Phase 4 paracetamol;ibuprofen
49 Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass Completed NCT02340247 Phase 4 Ursodeoxycholic Acid;Chenodeoxycholic Acid
50 Pharmacokinetics of Propofol in Morbidly Obese Patients Completed NCT01536002 Phase 4 Propofol

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Genetic Tests for Overnutrition

Anatomical Context for Overnutrition

MalaCards organs/tissues related to Overnutrition:

38
Liver, Brain, Heart, Bone, Testes, Endothelial, Breast

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 219)
# Title Authors Year
1
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice. ( 29390923 )
2018
2
Metformin influences on respiratory system in obese mice induced by postnatal overnutrition. ( 28963087 )
2018
3
Fetal Overnutrition and Adolescent Hepatic Fat Fraction: the Exploring Perinatal Outcomes in Children Study. ( 29046229 )
2018
4
The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. ( 29077836 )
2018
5
Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. ( 28940822 )
2017
6
Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. ( 28794439 )
2017
7
Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. ( 28958692 )
2017
8
Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )
2017
9
Exacerbation of liver steatosis following exposure to famine and overnutrition. ( 28499082 )
2017
10
Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. ( 28594364 )
2017
11
An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. ( 28697444 )
2017
12
Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. ( 28527530 )
2017
13
Preparing for the first breath: in the developing lung, maternal overnutrition takes center stage. ( 28925540 )
2017
14
Placental Lipid and Fatty Acid Transfer in Maternal Overnutrition. ( 28301855 )
2017
15
Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. ( 28759122 )
2017
16
Fetal overnutrition and offspring insulin resistance and I^-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study. ( 28636758 )
2017
17
Postnatal overnutrition affects metabolic and vascular function reflected by physiological and histological changes in the aorta of adult Wistar rats. ( 29115861 )
2017
18
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. ( 28677122 )
2017
19
Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. ( 27701408 )
2016
20
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )
2016
21
Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats. ( 27469432 )
2016
22
From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century. ( 27544200 )
2016
23
Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )
2016
24
Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. ( 27195103 )
2016
25
Overnutrition, ectopic lipid and the metabolic syndrome. ( 27194746 )
2016
26
Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. ( 26203167 )
2015
27
Association of Vitamin A Status with Overnutrition in Children and Adolescents. ( 26690192 )
2015
28
The double burden of under- and overnutrition and nutrient adequacy among Chinese preschool and school-aged children in 2009-2011. ( 26130296 )
2015
29
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. ( 26407845 )
2015
30
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. ( 25685686 )
2015
31
The Double Burden of Undernutrition and Overnutrition in Developing Countries: an Update. ( 26627492 )
2015
32
FGF1 Mediates Overnutrition-Induced Compensatory I^-Cell Differentiation. ( 26420862 )
2015
33
Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. ( 26690419 )
2015
34
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-I^ coactivator-1I+ in rats. ( 25675425 )
2015
35
Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. ( 25504042 )
2015
36
The changing context of overnutrition and undernutrition in Pakistan. ( 25794668 )
2015
37
Impact of maternal overnutrition on the periconceptional period. ( 25733194 )
2015
38
Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. ( 26497334 )
2015
39
Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. ( 25835281 )
2015
40
Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats. ( 26302954 )
2015
41
Childhood dual burden of under- and overnutrition in low- and middle-income countries: a critical review. ( 25076771 )
2014
42
Impact of maternal overnutrition on gluconeogenic factors and methylation of the phosphoenolpyruvate carboxykinase promoter in the fetal and postnatal liver. ( 24452591 )
2014
43
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. ( 25204637 )
2014
44
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. ( 25082159 )
2014
45
Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. ( 25673017 )
2014
46
Multi-generational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters. ( 25354845 )
2014
47
Overnutrition, mTOR signaling, and cardiovascular diseases. ( 25253086 )
2014
48
Maternal overnutrition enhances mRNA expression of adipogenic markers and collagen deposition in skeletal muscle of beef cattle fetuses. ( 25006073 )
2014
49
Shifting of undernutrition to overnutrition and its determinants among women of reproductive ages in the 36 low to medium income countries. ( 24925607 )
2014
50
Overnutrition induces I^-cell differentiation through prolonged activation of I^-cells in zebrafish larvae. ( 24473439 )
2014

Variations for Overnutrition

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for Overnutrition

Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 ADIPOQ IL6 INS LEP LEPR PPARG
2
Show member pathways
12.62 ADIPOQ IL6 INS LEP RETN SOCS3
3 12.44 ADIPOQ FTO INS PPARG UCP1
4
Show member pathways
12.35 ADIPOQ INS LEP LEPR PPARG
5
Show member pathways
12.27 IL6 LEP LEPR SOCS3
6
Show member pathways
12.24 CRP IL6 INS TNF
8
Show member pathways
11.85 IL6 INS SOCS3 TNF
9
Show member pathways
11.76 ADIPOQ INS SOCS3 TNF
10
Show member pathways
11.73 CRP IL6 SOCS3
11 11.72 ADIPOQ IL6 INS LEP PPARG UCP1
12 11.64 ADIPOQ PPARG UCP1
13 11.57 FGF1 IL6 TNF
14 11.49 IL6 INS SOCS3
15 11.43 INS LEP LEPR SOCS3
16 11.42 FGF1 IL6 INS
17 11.4 ADIPOQ IL6 INS LEP PPARG RETN
18 11.34 ADIPOQ AGRP LEP LEPR NPY SOCS3
19 11.27 IL6 SOCS3 TNF
20
Show member pathways
11.1 CRP LEP LEPR SOCS3
21 11.07 ADIPOQ LEP PPARG
22 10.91 CRP IL6 TNF
23 10.9 ADIPOQ IL6 LEP PPARG TNF
24 10.5 FTO UCP1

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ADIPOQ AGRP CRP FGF1 GHRL IL6
2 extracellular space GO:0005615 9.36 ADIPOQ AGRP CRP FGF1 GHRL IL6

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.88 FGF1 INS LEP TNF
2 positive regulation of MAPK cascade GO:0043410 9.87 IL6 INS LEP
3 negative regulation of inflammatory response GO:0050728 9.86 ADIPOQ GHRL SOCS3
4 circadian rhythm GO:0007623 9.86 ADIPOQ AGRP LEP
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IL6 INS
6 response to nutrient GO:0007584 9.84 ADIPOQ LEP PPARG
7 regulation of blood pressure GO:0008217 9.83 LEP NPY PPARG
8 response to insulin GO:0032868 9.83 AGRP LEP MC4R RETN
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 IL6 LEP SOCS3
10 response to glucocorticoid GO:0051384 9.82 ADIPOQ IL6 TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 IL6 RETN TNF
12 regulation of protein phosphorylation GO:0001932 9.79 LEP SOCS3 TNF
13 negative regulation of fat cell differentiation GO:0045599 9.79 ADIPOQ IL6 TNF
14 response to nutrient levels GO:0031667 9.76 ADIPOQ GHRL LEP UCP1
15 feeding behavior GO:0007631 9.75 AGRP MC4R NPY
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 INS TNF TRPV1
17 acute-phase response GO:0006953 9.72 CRP IL6 INS
18 glucose homeostasis GO:0042593 9.72 ADIPOQ INS LEP LEPR PPARG
19 negative regulation of collagen biosynthetic process GO:0032966 9.69 IL6 PPARG
20 energy reserve metabolic process GO:0006112 9.69 LEP LEPR MC4R
21 positive regulation of sprouting angiogenesis GO:1903672 9.68 FGF1 GHRL
22 positive regulation of insulin receptor signaling pathway GO:0046628 9.68 INS LEP
23 central nervous system neuron development GO:0021954 9.68 LEP NPY
24 negative regulation of glucose import GO:0046325 9.67 LEP TNF
25 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ADIPOQ CRP PPARG
26 sexual reproduction GO:0019953 9.66 LEP LEPR
27 negative regulation of blood vessel diameter GO:0097756 9.66 CRP INS
28 leptin-mediated signaling pathway GO:0033210 9.65 LEP LEPR
29 negative regulation of gluconeogenesis GO:0045721 9.65 ADIPOQ INS LEPR
30 glucose metabolic process GO:0006006 9.65 ADIPOQ GHRL INS LEP TNF
31 positive regulation of feeding behavior GO:2000253 9.63 AGRP GHRL
32 regulation of bone remodeling GO:0046850 9.63 LEP LEPR
33 negative regulation of acute inflammatory response GO:0002674 9.62 INS PPARG
34 regulation of brown fat cell differentiation GO:0090335 9.61 FTO LEP
35 regulation of feeding behavior GO:0060259 9.61 AGRP LEPR MC4R
36 positive regulation of STAT protein import into nucleus GO:2000366 9.6 IL6 LEP
37 regulation of metabolic process GO:0019222 9.59 LEP MC4R
38 diet induced thermogenesis GO:0002024 9.58 MC4R TRPV1 UCP1
39 positive regulation of appetite GO:0032100 9.56 GHRL NPY
40 bone growth GO:0098868 9.54 LEP LEPR
41 negative regulation of feeding behavior GO:2000252 9.54 INS MC4R RETN
42 adult feeding behavior GO:0008343 9.46 AGRP GHRL LEP NPY
43 regulation of receptor activity GO:0010469 9.32 ADIPOQ AGRP FGF1 GHRL IL6 INS
44 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 LEP TNF

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 ADIPOQ AGRP CRAT LEP NPY
2 identical protein binding GO:0042802 9.5 ADIPOQ CRP INS LEPR PPARG TNF
3 hormone activity GO:0005179 9.1 ADIPOQ GHRL INS LEP NPY RETN

Sources for Overnutrition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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43 MGI
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51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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