MCID: OVR063
MIFTS: 48

Overnutrition

Categories: Metabolic diseases

Aliases & Classifications for Overnutrition

MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:654
MeSH 42 D044343
SNOMED-CT 64 302872003
UMLS 69 C1257763

Summaries for Overnutrition

MalaCards based summary : Overnutrition is related to achard thiers syndrome and acquired hypoprothrombinemia. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Aspirin and Moxonidine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 72 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 achard thiers syndrome 11.0 ADIPOQ PPARG
2 acquired hypoprothrombinemia 11.0 ADIPOQ LEP RETN
3 chronic fungal otitis externa 11.0 CRP INS
4 lissencephaly 11.0 INS LEP PPARG
5 leigh syndrome with leukodystrophy 11.0 ADIPOQ LEP RETN
6 neurogenic arthropathy 11.0 ADIPOQ INS LEP
7 mucinoses 11.0 ADIPOQ INS LEP
8 idiopathic juxtafoveal retinal telangiectasia 10.9 ADIPOQ INS PPARG
9 obesity, mc4r-related 10.9 GHRL MC4R
10 obesity, ppargc1b-related 10.9 MC4R UCP1
11 corpus callosum agenesis of blepharophimosis robin type 10.9 ADIPOQ LEP RETN
12 acute insulin response 10.9 CRP INS UCP1
13 hypomagnesemia 3, renal 10.9 ADIPOQ INS LEP PPARG
14 optic atrophy 6 10.9 AGRP MC4R TRPV1
15 exophthalmic ophthalmoplegia 10.9 ADIPOQ LEP LEPR
16 mediastinum leiomyoma 10.9 CRP GHRL LEP
17 mature gastric teratoma 10.9 ADIPOQ INS LEP PPARG
18 hyperinsulinemic hypoglycemia, familial, 4 10.9 ADIPOQ GHRL INS PPARG
19 antidepressant type abuse 10.8 ADIPOQ INS LEP RETN
20 spondylolysis 10.8 IL6 INS TRPV1
21 collagenopathy type 2 alpha 1 10.8 CRP IL6
22 colonic disease 10.8 CRP IL6 LEP
23 peroneal neuropathy 10.8 ADIPOQ INS LEP PPARG
24 intramuscular hemangioma 10.8 CRP INS LEP RETN
25 brain glioblastoma multiforme 10.8 CRP IL6 TRPV1
26 ovarian clear cell malignant adenofibroma 10.8 ADIPOQ CRP INS
27 luxation of globe 10.8 CRP IL6 NPY
28 calcinosis 10.8 CRP IL6 INS TRPV1
29 avoidant personality disorder 10.8 IL6 INS TRPV1
30 chronic myelomonocytic leukemia 10.8 CRP IL6 INS LEP
31 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 10.8 GHRL PYY TRPV1
32 nonsyndromic hereditary sensorineural hearing loss 10.8 ADIPOQ INS LEP PPARG RETN
33 ragweed sensitivity 10.7 ADIPOQ CRP IL6 PPARG
34 neovascular glaucoma 10.7 CRP IL6 TRPV1
35 endometrial clear cell adenocarcinoma 10.7 CRP GHRL IL6 TRPV1
36 skin squamous cell carcinoma 10.7 ADIPOQ CRP INS LEP PPARG
37 crystal arthropathies 10.7 CRP IL6
38 chondroma 10.7 CRP IL6 INS LEP TRPV1
39 angelman syndrome 10.7 ADIPOQ AGRP GHRL LEP PYY
40 mesenchymal cell neoplasm 10.7 CRP IL6 TRPV1
41 dientamoebiasis 10.7 ADIPOQ IL6 INS LEP LEPR
42 skin meningioma 10.7 GHRL INS LEP
43 peripheral artery disease 10.7 ADIPOQ CRP IL6 INS
44 bacterial gastritis 10.7 CRP IL6 TRPV1
45 scleredema adultorum 10.7 ADIPOQ IL6 LEP RETN UCP1
46 hypertension, essential 10.7 ADIPOQ INS LEP NPY RETN
47 myh-9 related disease 10.7 INS LEP
48 pericarditis 10.7 ADIPOQ CRP INS PPARG RETN
49 shoulder impingement syndrome 10.7 CRP IL6
50 myelophthisic anemia 10.7 ADIPOQ CRP IL6 INS PPARG

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition

Symptoms & Phenotypes for Overnutrition

MGI Mouse Phenotypes related to Overnutrition:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.46 AGRP CRAT CRP FGF1 FTO GHRL
2 adipose tissue MP:0005375 10.44 ADIPOQ AGRP FTO GHRL IL6 INS
3 behavior/neurological MP:0005386 10.37 ADIPOQ AGRP FTO GHRL IL6 INS
4 growth/size/body region MP:0005378 10.35 TRPV1 UCP1 LEPR MC4R NPY PPARG
5 cardiovascular system MP:0005385 10.29 ADIPOQ CRAT CRP IL6 INS LEP
6 immune system MP:0005387 10.21 SOCS3 TRPV1 ADIPOQ CRP FTO IL6
7 liver/biliary system MP:0005370 10.18 RETN SOCS3 TRPV1 ADIPOQ AGRP FTO
8 integument MP:0010771 10.06 ADIPOQ FTO IL6 INS LEP LEPR
9 digestive/alimentary MP:0005381 10.04 GHRL IL6 INS LEP LEPR NPY
10 nervous system MP:0003631 10 AGRP FGF1 IL6 INS LEP LEPR
11 neoplasm MP:0002006 9.87 ADIPOQ IL6 LEP LEPR MC4R PPARG
12 normal MP:0002873 9.85 AGRP FGF1 GHRL INS LEPR MC4R
13 renal/urinary system MP:0005367 9.61 ADIPOQ FTO IL6 INS LEP LEPR
14 skeleton MP:0005390 9.36 ADIPOQ FTO IL6 INS LEP LEPR

Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 586)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Early Phase 1 50-78-2 2244
2
Moxonidine Approved Phase 4 75438-57-2 4810
3
Dalteparin Approved Phase 4,Phase 1 9005-49-6
4
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2 9005-49-6 772 46507594
5
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
6
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
7
Rocuronium Approved Phase 4,Phase 2 119302-91-9, 143558-00-3 441290
8
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
9
Acetaminophen Approved Phase 4,Phase 3,Phase 1,Early Phase 1 103-90-2 1983
10
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 14219 4091
11
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 5460373 44475014
12
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
13
Orlistat Approved, Investigational Phase 4,Phase 3,Phase 2 96829-58-2 3034010
14
Saxagliptin Approved Phase 4 361442-04-8 11243969
15 Nadroparin Approved Phase 4 9041-08-1
16
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
17
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 141758-74-9 15991534
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
19
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
20
Glycerol Approved, Investigational Phase 4 56-81-5 753
21
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
22
Zinc Approved Phase 4,Phase 2,Early Phase 1 7440-66-6 32051 23994
23
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
24
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
25
Phentermine Approved, Illicit Phase 4,Phase 3,Phase 2 122-09-8 4771
26
Topiramate Approved Phase 4,Phase 3,Phase 2 97240-79-4 5284627
27
Cefazolin Approved Phase 4 25953-19-9 656510 33255
28
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
29
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
30
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2 83150-76-9 383414 6400441
31
Ibuprofen Approved Phase 4 15687-27-1 3672
32
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
33
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
34
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
35
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
36
Sulfamethoxazole Approved Phase 4 723-46-6 5329
37
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
38
Dapsone Approved, Investigational Phase 4 80-08-0 2955
39
Ethambutol Approved Phase 4 74-55-5 3279 14052
40
Infliximab Approved Phase 4 170277-31-3
41
Methyltestosterone Approved Phase 4,Phase 3,Phase 2 58-18-4 6010
42
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 58-22-0 6013
43
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2 58-93-5 3639
44
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 111025-46-8 4829
45
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
46
Candesartan Approved Phase 4 139481-59-7 2541
47
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
48
Galantamine Approved Phase 4 357-70-0 9651
49
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
50
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713

Interventional clinical trials:

(show top 50) (show all 1989)

id Name Status NCT ID Phase Drugs
1 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
2 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
3 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
4 The Therapeutic Effect of Catgut Embedding in Obesity Unknown status NCT02276235 Phase 4
5 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
6 Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity Unknown status NCT01970202 Phase 4 40mg Enoxaparin;60mg Enoxaparin
7 Pharmacokinetics of Dexmedetomidine in Morbid Obesity Unknown status NCT01864187 Phase 4 Dexmedetomidine
8 Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
9 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity Unknown status NCT01550601 Phase 4
10 The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity Unknown status NCT01405352 Phase 4
11 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
12 VAS Correlation With BMI Unknown status NCT02017314 Phase 4 Morphine
13 Pharmacokinetics of Acetaminophen in Morbidly Obese Patients Unknown status NCT01764555 Phase 4 acetaminophen 2 g
14 Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
15 Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
16 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
17 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Unknown status NCT00288873 Phase 4 Ergocalciferol;Cholecalciferol
18 Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4 Metformin
19 Vitamin Deficiencies and Suppletion in Morbid Obesity Unknown status NCT02270749 Phase 4 Hydroxocobalamin;FitForMe vitamin B12
20 The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension Unknown status NCT01360710 Phase 4 Moxonidine;Irbesartan
21 Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients Unknown status NCT00871845 Phase 4 Orlistat
22 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
23 Prophylaxis of Venous Thromboembolism After Bariatric Surgery Unknown status NCT02295150 Phase 4 Nadroparin
24 CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug Unknown status NCT01519726 Phase 4 Midazolam
25 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed NCT01090141 Phase 4 Micafungin;Micafungin
26 Bread in Overweight/Obesity Treatment Completed NCT01223989 Phase 4
27 A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents Completed NCT02714062 Phase 4 Placebo;VI-0521 Mid Dose;VI-0521 Top Dose
28 Use of Metformin in Treatment of Childhood Obesity Completed NCT02274948 Phase 4 Metformin;Placebo
29 Auricular Acupuncture in the Treatment of Obesity Completed NCT02269371 Phase 4
30 GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men Completed NCT02170324 Phase 4 Exenatide;Placebo
31 Increased Cefazolin During Cesarean Delivery in Obese Population Completed NCT02049944 Phase 4 Cefazolin
32 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
33 Enoxaparin Dosing in Obesity Completed NCT01798550 Phase 4 Enoxaparin
34 Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention Completed NCT01757925 Phase 4
35 Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity Completed NCT01639677 Phase 4
36 Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations Completed NCT01307930 Phase 4 Anidulafungin
37 A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women Completed NCT01206413 Phase 4
38 Fondaparinux Population Pharmacokinetic to Morbid Obese Patients in Post-operatory Bariatric Surgery Completed NCT01064596 Phase 4
39 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed NCT01062165 Phase 4 Caspofungin
40 Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs) Completed NCT00694811 Phase 4
41 Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band Completed NCT00543140 Phase 4
42 A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients Completed NCT00171613 Phase 4 Octreotide
43 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4 Sandostatin LAR
44 The Effect of Xenical on Weight and Risk Factors Completed NCT00152360 Phase 4 Orlistat
45 Micafungin Pharmacokinetics in Obese Patients Completed NCT03102658 Phase 4 Micafungin
46 Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery Completed NCT02778958 Phase 4 paracetamol;ibuprofen
47 Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass Completed NCT02340247 Phase 4 Ursodeoxycholic Acid;Chenodeoxycholic Acid
48 Pharmacokinetics of Propofol in Morbidly Obese Patients Completed NCT01536002 Phase 4 Propofol
49 Population PK/PD of Propofol in the Morbidly Obese Patient Completed NCT00395681 Phase 4 Diprivan
50 Investigations on the Influence of Bariatric Surgery on the Metabolism and Absorption of Atorvastatin Completed NCT00331565 Phase 4

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Genetic Tests for Overnutrition

Anatomical Context for Overnutrition

MalaCards organs/tissues related to Overnutrition:

39
Liver, Brain, Heart, Bone, Endothelial, Testes, Kidney

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 213)
id Title Authors Year
1
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. ( 28677122 )
2017
2
Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. ( 28527530 )
2017
3
Fetal overnutrition and offspring insulin resistance and I^-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study. ( 28636758 )
2017
4
Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. ( 28759122 )
2017
5
Exacerbation of liver steatosis following exposure to famine and overnutrition. ( 28499082 )
2017
6
Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. ( 28794439 )
2017
7
Placental Lipid and Fatty Acid Transfer in Maternal Overnutrition. ( 28301855 )
2017
8
Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. ( 28594364 )
2017
9
Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )
2017
10
An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. ( 28697444 )
2017
11
Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. ( 28940822 )
2017
12
Preparing for the first breath: in the developing lung, maternal overnutrition takes center stage. ( 28925540 )
2017
13
Overnutrition, ectopic lipid and the metabolic syndrome. ( 27194746 )
2016
14
Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. ( 27701408 )
2016
15
Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats. ( 27469432 )
2016
16
From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century. ( 27544200 )
2016
17
Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )
2016
18
Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. ( 27195103 )
2016
19
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )
2016
20
Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats. ( 26302954 )
2015
21
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. ( 26407845 )
2015
22
The changing context of overnutrition and undernutrition in Pakistan. ( 25794668 )
2015
23
Association of Vitamin A Status with Overnutrition in Children and Adolescents. ( 26690192 )
2015
24
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-I^ coactivator-1I+ in rats. ( 25675425 )
2015
25
Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. ( 26497334 )
2015
26
Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. ( 26690419 )
2015
27
FGF1 Mediates Overnutrition-Induced Compensatory I^-Cell Differentiation. ( 26420862 )
2015
28
Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. ( 26203167 )
2015
29
Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. ( 25835281 )
2015
30
Impact of maternal overnutrition on the periconceptional period. ( 25733194 )
2015
31
Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. ( 25504042 )
2015
32
The double burden of under- and overnutrition and nutrient adequacy among Chinese preschool and school-aged children in 2009-2011. ( 26130296 )
2015
33
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. ( 25685686 )
2015
34
The Double Burden of Undernutrition and Overnutrition in Developing Countries: an Update. ( 26627492 )
2015
35
Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. ( 25673017 )
2014
36
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. ( 25082159 )
2014
37
Overnutrition induces I^-cell differentiation through prolonged activation of I^-cells in zebrafish larvae. ( 24473439 )
2014
38
Childhood dual burden of under- and overnutrition in low- and middle-income countries: a critical review. ( 25076771 )
2014
39
Maternal overnutrition enhances mRNA expression of adipogenic markers and collagen deposition in skeletal muscle of beef cattle fetuses. ( 25006073 )
2014
40
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. ( 25204637 )
2014
41
Overnutrition, mTOR signaling, and cardiovascular diseases. ( 25253086 )
2014
42
Impact of maternal overnutrition on gluconeogenic factors and methylation of the phosphoenolpyruvate carboxykinase promoter in the fetal and postnatal liver. ( 24452591 )
2014
43
Shifting of undernutrition to overnutrition and its determinants among women of reproductive ages in the 36 low to medium income countries. ( 24925607 )
2014
44
Multi-generational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters. ( 25354845 )
2014
45
The paradox of overnutrition in aging and cognition. ( 23682739 )
2013
46
Testing the fetal overnutrition hypothesis; the relationship of maternal and paternal adiposity to adiposity, insulin resistance and cardiovascular risk factors in Indian children. ( 22895107 )
2013
47
Neuroinflammation in overnutrition-induced diseases. ( 23374717 )
2013
48
Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction. ( 23900419 )
2013
49
Association between insulin-like growth factor-1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north-west province, South Africa. ( 24375890 )
2013
50
Oxidative stress programming in a rat model of postnatal early overnutrition--role of insulin resistance. ( 22819562 )
2013

Variations for Overnutrition

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for Overnutrition

Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 ADIPOQ IL6 INS LEP LEPR PPARG
2
Show member pathways
12.62 ADIPOQ IL6 INS LEP RETN SOCS3
3 12.36 ADIPOQ FTO INS PPARG UCP1
4
Show member pathways
12.34 INS LEP LEPR SOCS3
5
Show member pathways
12.29 ADIPOQ INS LEP LEPR PPARG
7
Show member pathways
12.06 IL6 LEP LEPR SOCS3
8
Show member pathways
11.74 ADIPOQ INS SOCS3
9
Show member pathways
11.69 CRP IL6 SOCS3
10 11.62 ADIPOQ IL6 INS LEP PPARG UCP1
11 11.6 ADIPOQ PPARG UCP1
12 11.45 IL6 INS SOCS3
13 11.4 INS LEP LEPR SOCS3
14 11.37 FGF1 IL6 INS
15 11.35 ADIPOQ IL6 INS LEP PPARG RETN
16 11.27 ADIPOQ AGRP LEP LEPR NPY SOCS3
17
Show member pathways
11.1 CRP LEP LEPR SOCS3
18 11.01 ADIPOQ LEP PPARG
19 10.9 ADIPOQ IL6 LEP PPARG
20 10.45 FTO UCP1

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ADIPOQ AGRP CRP FGF1 GHRL IL6
2 extracellular space GO:0005615 9.36 ADIPOQ AGRP CRP FGF1 GHRL IL6

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 45)
id Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.87 AGRP NPY PYY
2 positive regulation of protein kinase B signaling GO:0051897 9.86 IL6 INS LEP
3 negative regulation of inflammatory response GO:0050728 9.85 ADIPOQ GHRL SOCS3
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IL6 INS
5 positive regulation of MAPK cascade GO:0043410 9.85 IL6 INS LEP
6 circadian rhythm GO:0007623 9.84 ADIPOQ AGRP LEP
7 response to nutrient GO:0007584 9.84 ADIPOQ LEP PPARG
8 regulation of blood pressure GO:0008217 9.81 LEP NPY PPARG
9 glucose metabolic process GO:0006006 9.81 ADIPOQ GHRL INS LEP
10 response to mechanical stimulus GO:0009612 9.8 IL6 PPARG RETN
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL6 INS TRPV1
12 response to cold GO:0009409 9.75 IL6 PPARG UCP1
13 acute-phase response GO:0006953 9.73 CRP IL6 INS
14 response to insulin GO:0032868 9.72 AGRP IL6 LEP MC4R RETN
15 feeding behavior GO:0007631 9.71 AGRP MC4R NPY PYY
16 energy reserve metabolic process GO:0006112 9.7 LEP LEPR MC4R
17 regulation of fat cell differentiation GO:0045598 9.69 LEP PPARG
18 fatty acid oxidation GO:0019395 9.69 ADIPOQ PPARG
19 negative regulation of collagen biosynthetic process GO:0032966 9.68 IL6 PPARG
20 central nervous system neuron development GO:0021954 9.68 LEP NPY
21 positive regulation of insulin receptor signaling pathway GO:0046628 9.67 INS LEP
22 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ADIPOQ CRP PPARG
23 negative regulation of hormone secretion GO:0046888 9.66 ADIPOQ IL6
24 sexual reproduction GO:0019953 9.65 LEP LEPR
25 response to caffeine GO:0031000 9.65 IL6 PPARG
26 regulation of feeding behavior GO:0060259 9.65 AGRP LEPR MC4R
27 regulation of appetite GO:0032098 9.64 NPY PYY
28 leptin-mediated signaling pathway GO:0033210 9.63 LEP LEPR
29 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 LEP
30 negative regulation of acute inflammatory response GO:0002674 9.62 INS PPARG
31 regulation of bone remodeling GO:0046850 9.61 LEP LEPR
32 diet induced thermogenesis GO:0002024 9.61 MC4R TRPV1 UCP1
33 regulation of brown fat cell differentiation GO:0090335 9.6 FTO LEP
34 regulation of metabolic process GO:0019222 9.59 LEP MC4R
35 positive regulation of appetite GO:0032100 9.57 GHRL NPY
36 response to nutrient levels GO:0031667 9.56 ADIPOQ IL6 LEP UCP1
37 positive regulation of STAT protein import into nucleus GO:2000366 9.55 IL6 LEP
38 bone growth GO:0098868 9.54 LEP LEPR
39 negative regulation of feeding behavior GO:2000252 9.54 INS MC4R RETN
40 negative regulation of gluconeogenesis GO:0045721 9.46 ADIPOQ IL6 INS LEPR
41 glucose homeostasis GO:0042593 9.43 ADIPOQ IL6 INS LEP LEPR PPARG
42 positive regulation of sprouting angiogenesis GO:1903672 9.35 FGF1
43 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 IL6
44 positive regulation of feeding behavior GO:2000253 9.31 AGRP
45 adult feeding behavior GO:0008343 8.92 AGRP GHRL LEP NPY

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor binding GO:0001664 9.43 GHRL NPY PYY
2 receptor binding GO:0005102 9.43 ADIPOQ AGRP CRAT IL6 LEP NPY
3 neuropeptide hormone activity GO:0005184 9.33 AGRP NPY PYY
4 hormone activity GO:0005179 9.17 ADIPOQ GHRL INS LEP NPY PYY

Sources for Overnutrition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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