Aliases & Classifications for Oxyphilic Adenoma

MalaCards integrated aliases for Oxyphilic Adenoma:

Name: Oxyphilic Adenoma 12 14 69
Oncocytoma 12 52
Follicular Adenoma, Oxyphilic Cell 12
Adenoma, Oxyphilic 42
Hurthle Cell Tumor 69
Oncocytic Neoplasm 69

Characteristics:

HPO:

32
oxyphilic adenoma:
Inheritance mitochondrial inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:5389
MeSH 42 D018249
NCIt 47 C3759
SNOMED-CT 64 89439007
SNOMED-CT via HPO 65 108369006 363346000
UMLS 69 C1510502

Summaries for Oxyphilic Adenoma

MalaCards based summary : Oxyphilic Adenoma, also known as oncocytoma, is related to renal oncocytoma and familial renal oncocytoma, and has symptoms including abnormality of metabolism/homeostasis and neoplasm. An important gene associated with Oxyphilic Adenoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Radiopharmaceuticals and Technetium Tc 99m Sestamibi have been mentioned in the context of this disorder. Affiliated tissues include kidney, salivary gland and thyroid, and related phenotypes are cardiovascular system and cellular

Related Diseases for Oxyphilic Adenoma

Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 renal oncocytoma 12.4
2 familial renal oncocytoma 12.0
3 birt-hogg-dube syndrome 10.8
4 thyroid hurthle cell adenoma 10.8
5 angelman syndrome due to a point mutation 10.7 AMACR MME
6 malignant sertoli-leydig cell tumor 10.7 KIT MME
7 malignant growth hormone secreting neoplasm of pituitary 10.7 FH FLCN
8 phlebotomus fever 10.7 AMACR PAX2
9 mucinous adenofibroma 10.7 AMACR PAX2
10 sphenoid sinus squamous cell carcinoma 10.7 KIT MME
11 liver angiosarcoma 10.7 KIT MME
12 thymic dysplasia 10.7 AMACR PAX2
13 retinitis 10.6 MME PAX2
14 collecting duct carcinoma 10.6 FH FLCN
15 spiradenoma 10.6 KIT MME
16 glomus tumor 10.6 KIT SYP
17 dystonia 10.6 MME SYP
18 invasive malignant thymoma 10.6 KIT SYP
19 gallbladder adenocarcinoma 10.6 MME SYP
20 thymus small cell carcinoma 10.5 KIT SYP
21 renal cell carcinoma 10.5
22 pneumothorax, primary spontaneous 10.5 FH FLCN
23 pseudomyxoma peritonei 10.5 KIT VIM
24 malignant teratoma 10.5 KIT SYP
25 mannose-binding lectin protein deficiency 10.5 KIT VIM
26 encephalitozoonosis 10.5 KIT SYP
27 pancreatic agenesis 10.5 KIT SYP
28 diffuse meningeal melanocytosis 10.5 KIT VIM
29 lymphangiosarcoma 10.5 MME VIM
30 ovary papillary carcinoma 10.5 AMACR VIM
31 alcohol-induced mental disorder 10.5 KIT VIM
32 benign tumor of fallopian tubes 10.5 LGALS3 PAX2
33 bladder colloid adenocarcinoma 10.4 PAX2 VIM
34 malignant breast melanoma 10.4 KIT VIM
35 mucinous adenocarcinoma 10.4 AMACR KIT PAX2
36 proliferative type fibrocystic change of breast 10.4 FH SYP
37 esophagus leiomyosarcoma 10.4 FH VIM
38 placental insufficiency 10.4 KIT SYP
39 2q31.1 microdeletion syndrome 10.4 SYP VIM
40 chromophobe renal cell carcinoma 10.4
41 urethral villous adenoma 10.4 KIT MME PAX2
42 perivascular epithelioid cell tumor 10.4 KIT MME PAX2
43 neurogenic thoracic outlet syndrome 10.4 SYP VIM
44 mesenchymoma 10.3 KIT VIM
45 skin papilloma 10.3 SYP VIM
46 reticular pattern testicular yolk sac tumor 10.3 SYP VIM
47 adult medulloblastoma 10.3 SYP VIM
48 prostate disease 10.3 KIT VIM
49 axonal neuropathy 10.3 SYP VIM
50 anaplastic oligodendroglioma 10.3 SYP VIM

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to Oxyphilic Adenoma

Symptoms & Phenotypes for Oxyphilic Adenoma

Human phenotypes related to Oxyphilic Adenoma:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 neoplasm 32 HP:0002664

MGI Mouse Phenotypes related to Oxyphilic Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 FLCN KIT KRT8 LGALS3 MT-ND6 PAX2
2 cellular MP:0005384 9.81 PAX2 RASSF1 SLC25A5 VIM FH FLCN
3 homeostasis/metabolism MP:0005376 9.65 AMACR FH FLCN KIT KRT8 LGALS3
4 liver/biliary system MP:0005370 9.1 AMACR KIT KRT8 LGALS3 MME RASSF1

Drugs & Therapeutics for Oxyphilic Adenoma

Drugs for Oxyphilic Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Radiopharmaceuticals
2 Technetium Tc 99m Sestamibi

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Recruiting NCT01767636 Phase 2 Pazopanib Hydrochloride
2 Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples Completed NCT00001814
3 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Recruiting NCT02160925
4 Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer Terminated NCT00491621

Search NIH Clinical Center for Oxyphilic Adenoma

Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oxyphilic Adenoma

Anatomical Context for Oxyphilic Adenoma

MalaCards organs/tissues related to Oxyphilic Adenoma:

39
Kidney, Salivary Gland, Thyroid

Publications for Oxyphilic Adenoma

Articles related to Oxyphilic Adenoma:

id Title Authors Year
1
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. ( 3927580 )
1985
2
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. ( 674638 )
1978
3
The angiographic appearance of benign renal oxyphilic adenoma. ( 973655 )
1976
4
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. ( 4118915 )
1973
5
Oxyphilic adenoma of the larynx. ( 5027594 )
1972
6
Onkocytoma (oxyphilic adenoma) of the caruncle. ( 6036309 )
1967
7
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. ( 14310177 )
1965
8
Oxyphilic adenoma of the parotid gland; report of a case. ( 13172681 )
1954

Variations for Oxyphilic Adenoma

ClinVar genetic disease variations for Oxyphilic Adenoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh37 Chromosome MT, 14248: 14248

Expression for Oxyphilic Adenoma

Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for Oxyphilic Adenoma

Pathways related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.03 PAX2 SYP VIM
2 10.79 KRT8 MME PAX2 VIM
3 10.41 CDH16 VIM

GO Terms for Oxyphilic Adenoma

Cellular components related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 MME SYP

Biological processes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 8.96 KIT PAX2
2 negative regulation of programmed cell death GO:0043069 8.62 KIT PAX2

Sources for Oxyphilic Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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