MCID: OXY002
MIFTS: 32

Oxyphilic Adenoma malady

Category: Cancer diseases

Aliases & Classifications for Oxyphilic Adenoma

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Aliases & Descriptions for Oxyphilic Adenoma:

Name: Oxyphilic Adenoma 11 13 67
Oncocytoma 11 49
Follicular Adenoma, Oxyphilic Cell 11
 
Hurthle Cell Tumor 67
Adenoma, Oxyphilic 38
Oncocytic Neoplasm 67

Characteristics:

HPO:

63

Classifications:



External Ids:

Disease Ontology11 DOID:5389
MeSH38 D018249
SNOMED-CT61 89439007
NCIt44 C3759

Summaries for Oxyphilic Adenoma

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MalaCards based summary: Oxyphilic Adenoma, also known as oncocytoma, is related to renal cell carcinoma and renal oncocytoma, and has symptoms including abnormality of metabolism/homeostasis and neoplasm. An important gene associated with Oxyphilic Adenoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include kidney, salivary gland and thyroid, and related mouse phenotypes are neoplasm and liver/biliary system.

Related Diseases for Oxyphilic Adenoma

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Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma27.1AMACR, CDH16, FH, FLCN, KIT, KRT8
2renal oncocytoma12.4
3familial renal oncocytoma12.0
4birt-hogg-dube syndrome10.8
5thyroid hurthle cell adenoma10.8
6global developmental delay-lung cysts-overgrowth-wilms tumor syndrome10.6AMACR, MME
7malignant sertoli-leydig cell tumor10.6KIT, MME
8dysembryoplastic neuroepithelial tumor10.6KIT, MME
9sphenoidal sinus cancer10.6KIT, MME
10localized pulmonary fibrosis10.6KIT, MME
11liver sarcoma10.6AMACR, PAX2
12ovarian stromal hyperthecosis10.6AMACR, PAX2
13acute retinal necrosis syndrome10.6MME, PAX2
14bladder flat intraepithelial lesion10.5MME, SYP
15transient hypogammaglobulinemia10.5FH, FLCN
16gallbladder signet ring cell adenocarcinoma10.5MME, SYP
17multilocular clear cell renal cell carcinoma10.5FH, FLCN
18clear cell hidradenoma10.5KIT, MME
19skin glomus tumor10.5KIT, SYP
20prostate small cell carcinoma10.5KIT, SYP
21ocular melanoma10.5KIT, MME
22acanthoma10.4MME, SYP
23akinetic mutism10.4KIT, SYP
24prostatic urethral cancer10.4FH, FLCN
25skin sarcoma10.4MME, VIM
26pancreatic agenesis10.4KIT, SYP
27chromophobe renal cell carcinoma10.4
28ovarian surface papilloma10.4AMACR, VIM
29retinal ischemia10.4FLCN, KIT, MME
30tooth erosion10.4KIT, VIM
31lynch syndrome10.4KIT, SYP
32non-gestational choriocarcinoma10.4MME, VIM
332q33.1 microdeletion syndrome10.4SYP, VIM
34syringomyelia10.4FH, SYP
35nephrogenic adenofibroma10.4KIT, SYP
36extracranial neuroblastoma10.3PAX2, VIM
37epithelioid cell melanoma10.3KIT, VIM
38anaplastic oligoastrocytoma10.3SYP, VIM
39fraxf syndrome10.3SYP, VIM
40lumbar plexus neoplasm10.3SYP, VIM
41sm-ahnmd10.3SYP, VIM
42pineoblastoma10.3SYP, VIM
43colon mucinous adenocarcinoma10.3AMACR, KIT, PAX2
44gallbladder adenoma10.3SYP, VIM
45laryngeal disease10.3KIT, VIM
46congenital hypogammaglobulinemia10.3SYP, VIM
47skin glomangioma10.3SYP, VIM
48female reproductive endometrioid cancer10.3SYP, VIM
49ependymoblastoma10.3SYP, VIM
50pineal parenchymal tumor of intermediate differenciation10.3SYP, VIM

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to oxyphilic adenoma

Symptoms for Oxyphilic Adenoma

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Human phenotypes related to Oxyphilic Adenoma:

 63
id Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis63 HP:0001939
2 neoplasm63 HP:0002664

Drugs & Therapeutics for Oxyphilic Adenoma

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Drugs for Oxyphilic Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Technetium Tc 99m Sestamibi34
2Radiopharmaceuticals485

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney CancerRecruitingNCT01767636Phase 2
2Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of SamplesCompletedNCT00001814
3Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal OncocytomaRecruitingNCT02160925
4Evaluation of Diagnostic Value of Molecular Markers in Renal CancerTerminatedNCT00491621

Search NIH Clinical Center for Oxyphilic Adenoma


Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oxyphilic Adenoma

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Anatomical Context for Oxyphilic Adenoma

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MalaCards organs/tissues related to Oxyphilic Adenoma:

35
Kidney, Salivary gland, Thyroid

Animal Models for Oxyphilic Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Oxyphilic Adenoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5FLCN, KIT, LGALS3, MT-ND6, RASSF1
2MP:00053708.3AMACR, KIT, KRT8, LGALS3, MME, RASSF1
3MP:00053847.6FH, FLCN, KIT, LGALS3, MT-ND6, PAX2
4MP:00053857.6FLCN, KIT, KRT8, LGALS3, MT-ND6, PAX2
5MP:00053766.9AMACR, FH, FLCN, KIT, KRT8, LGALS3

Publications for Oxyphilic Adenoma

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Articles related to Oxyphilic Adenoma:

idTitleAuthorsYear
1
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. (3927580)
1985
2
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. (674638)
1978
3
The angiographic appearance of benign renal oxyphilic adenoma. (973655)
1976
4
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. (4118915)
1973
5
Oxyphilic adenoma of the larynx. (5027594)
1972
6
Onkocytoma (oxyphilic adenoma) of the caruncle. (6036309)
1967
7
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. (14310177)
1965
8
Oxyphilic adenoma of the parotid gland; report of a case. (13172681)
1954

Variations for Oxyphilic Adenoma

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Clinvar genetic disease variations for Oxyphilic Adenoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MT-ND6NC_012920.1: m.14248dupCduplicationPathogenicrs869312882GRCh37Chr MT, 14248: 14248

Expression for genes affiliated with Oxyphilic Adenoma

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Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for genes affiliated with Oxyphilic Adenoma

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Pathways related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2PAX2, SYP, VIM

GO Terms for genes affiliated with Oxyphilic Adenoma

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Cellular components related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:00443069.8MME, SYP

Biological processes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of programmed cell deathGO:00430699.8KIT, PAX2
2stem cell differentiationGO:00488639.7KIT, PAX2

Sources for Oxyphilic Adenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet