Aliases & Classifications for Oxyphilic Adenoma

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Aliases & Descriptions for Oxyphilic Adenoma:

Name: Oxyphilic Adenoma 11 13 66
Oncocytoma 11 48
Follicular Adenoma, Oxyphilic Cell 11
 
Hurthle Cell Tumor 66
Adenoma, Oxyphilic 37
Oncocytic Neoplasm 66

Characteristics:

HPO:

62


Classifications:



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Disease Ontology11 DOID:5389
MeSH37 D018249
SNOMED-CT60 89439007
NCIt43 C3759

Summaries for Oxyphilic Adenoma

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Wikipedia:69 An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of... more...

MalaCards based summary: Oxyphilic Adenoma, also known as oncocytoma, is related to renal cell carcinoma and renal oncocytoma, and has symptoms including abnormality of metabolism/homeostasis and neoplasm. An important gene associated with Oxyphilic Adenoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6). Affiliated tissues include kidney, salivary gland and thyroid, and related mouse phenotype renal/urinary system.

Related Diseases for Oxyphilic Adenoma

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Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma26.2AMACR, CDH16, CLDN7, CLDN8, FLCN, KIT
2renal oncocytoma12.4
3familial renal oncocytoma12.1
4thyroid hurthle cell adenoma10.9
5liver sarcoma10.6AMACR, PAX2
6ovarian stromal hyperthecosis10.6AMACR, PAX2
7acute retinal necrosis syndrome10.6MME, PAX2
8chromophobe renal cell carcinoma10.5
9tracheal lymphoma10.5MME, PAX2
10clear cell adenocarcinoma10.5AMACR, MME
11dysembryoplastic neuroepithelial tumor10.5KIT, MME
12sphenoidal sinus cancer10.5KIT, MME
13focal chorioretinitis10.5KIT, MME
14localized pulmonary fibrosis10.5KIT, MME
15parachordoma10.4KIT, MME
16clear cell hidradenoma10.4KIT, MME
17ocular melanoma10.4KIT, MME
18thyrotoxic periodic paralysis 210.4FLCN, FNIP1
19prostate colloid adenocarcinoma10.4KRT7, MME
20adult central nervous system choriocarcinoma10.4KRT7, MME
21multicentric reticulohistiocytosis10.4KRT7, MME
22pediatric ovarian dysgerminoma10.4KRT7, PAX2
23biliary tract neoplasm10.4KRT7, PAX2
24female breast lower-inner quadrant cancer10.4KRT7, MME
25breast neuroendocrine neoplasm10.4KRT7, MME
26adenoma10.4
27carotid artery dissection10.4AMACR, KRT7
28hyperaldosteronism10.4PAX2, PRCC
29hemangiopericytoma10.3KRT7, PAX2
30peritonitis10.3KIT, KRT7
31vulva basal cell carcinoma10.3KRT7, MME
32infiltrative basal cell carcinoma10.3KIT, KRT7
33epithelioid type angiomyolipoma10.3KIT, MME
34lacrimal passage granuloma10.3KRT7, MME
35spindle cell synovial sarcoma10.3KRT7, MME
36chromophobe adenocarcinoma10.3AMACR, PAX2
37pancreatic non-invasive mucinous cystadenocarcinoma10.2KRT7, MME
38verloove vanhorick brubakk syndrome10.2FLCN, PAX2
39colon mucinous adenocarcinoma10.2AMACR, KIT, PAX2
40breast pericanalicular fibroadenoma10.2KIT, MME
41sialolithiasis10.2KIT, KRT7
42global developmental delay-lung cysts-overgrowth-wilms tumor syndrome10.2AMACR, KRT7, MME
43nerve fibre bundle defect10.1KIT, KRT7
44mucinous adenofibroma10.1KRT7, MME, PAX2
45central nervous system vasculitis10.1MME, PAX2
46gastrointestinal neuroendocrine tumor10.1KIT, KRT7
47malignant sertoli-leydig cell tumor10.0KIT, KRT7, MME
48vibratory urticaria10.0KIT, KRT7, MME
49vestibular gland benign neoplasm10.0KIT, KRT7, MME
50cervical wilms' tumor10.0AMACR, KRT7, PRCC

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to oxyphilic adenoma

Symptoms for Oxyphilic Adenoma

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HPO human phenotypes related to Oxyphilic Adenoma:

id Description Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis HP:0001939
2 neoplasm HP:0002664

Drugs & Therapeutics for Oxyphilic Adenoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney CancerRecruitingNCT01767636Phase 2
2Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of SamplesCompletedNCT00001814
3Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal OncocytomaRecruitingNCT02160925
4Evaluation of Diagnostic Value of Molecular Markers in Renal CancerTerminatedNCT00491621

Search NIH Clinical Center for Oxyphilic Adenoma


Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oxyphilic Adenoma

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Anatomical Context for Oxyphilic Adenoma

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MalaCards organs/tissues related to Oxyphilic Adenoma:

34
Kidney, Salivary gland, Thyroid

Animal Models for Oxyphilic Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Oxyphilic Adenoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.0CLDN7, FLCN, FNIP1, KIT, KRT7, PAX2

Publications for Oxyphilic Adenoma

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Articles related to Oxyphilic Adenoma:

idTitleAuthorsYear
1
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. (3927580)
1985
2
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. (674638)
1978
3
The angiographic appearance of benign renal oxyphilic adenoma. (973655)
1976
4
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. (4118915)
1973
5
Oxyphilic adenoma of the larynx. (5027594)
1972
6
Onkocytoma (oxyphilic adenoma) of the caruncle. (6036309)
1967
7
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. (14310177)
1965
8
Oxyphilic adenoma of the parotid gland; report of a case. (13172681)
1954

Variations for Oxyphilic Adenoma

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Clinvar genetic disease variations for Oxyphilic Adenoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MT-ND6NC_012920.1: m.14248dupCduplicationPathogenicrs869312882GRCh37Chr MT, 14248: 14248

Expression for genes affiliated with Oxyphilic Adenoma

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Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for genes affiliated with Oxyphilic Adenoma

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GO Terms for genes affiliated with Oxyphilic Adenoma

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Cellular components related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apicolateral plasma membraneGO:00163279.5CLDN7, CLDN8
2basolateral plasma membraneGO:00163238.5CDH16, CLDN7, CLDN8

Biological processes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of pro-B cell differentiationGO:200097310.4FLCN, FNIP1
2immature B cell differentiationGO:000232710.2FNIP1, KIT
3stem cell differentiationGO:004886310.1KIT, PAX2
4regulation of protein phosphorylationGO:000193210.0FLCN, FNIP1
5negative regulation of TOR signalingGO:00320079.7FLCN, FNIP1
6negative regulation of programmed cell deathGO:00430699.7KIT, PAX2
7TOR signalingGO:00319299.5FLCN, FNIP1
8calcium-independent cell-cell adhesion via plasma membrane cell-adhesion moleculesGO:00163389.5CLDN7, CLDN8

Molecular functions related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051988.8CLDN7, CLDN8, KRT7

Sources for Oxyphilic Adenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet