MCID: OXY002
MIFTS: 34

Oxyphilic Adenoma malady

Cancer category

Summaries for Oxyphilic Adenoma

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33MalaCards
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MalaCards: Oxyphilic Adenoma, also known as oncocytoma, is related to adenoma and angiomyolipoma. An important gene associated with Oxyphilic Adenoma is FLCN (folliculin). The compounds 2-methoxyethanol and toluidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, salivary gland and ovary.

Aliases & Classifications for Oxyphilic Adenoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

oxyphilic adenoma 8 10
oncocytoma 8 45
follicular adenoma, oxyphilic cell 8
hurthle cell tumor 61


External Ids:

Disease Ontology8 DOID:5389
NCIt40 C3759
SNOMED-CT57 89439007
MeSH35 D018249

Related Diseases for Oxyphilic Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.9S100A1, KRT7
2angiomyolipoma30.4S100A1, VIM
3renal clear cell carcinoma30.2VIM, PVALB, CA9, S100A1, CDH16, CLDN7
4papillary adenoma30.0PRCC
5paraganglioma29.8S100A1
6myoepithelioma29.8VIM, S100A1
7chromophobe renal cell carcinoma10.7
8papillary carcinoma10.3
9papillary renal carcinoma10.3
10papillary renal cell carcinoma10.3
11familial renal oncocytoma10.2
12clear cell renal cell carcinoma10.2
13thyroid hurthle cell carcinoma10.2
14thyroid adenoma10.2
15tuberous sclerosis10.1
16n syndrome10.1
17pheochromocytoma10.1
18pituicytoma10.1
19null pituitary adenoma10.1
20small cell carcinoma10.0
21granular cell tumor10.0
22granular cell carcinoma10.0
23chromophobe adenoma10.0
24horseshoe kidney10.0
25pituitary tumors10.0
26perivascular epithelioid cell tumor10.0TFE3
27lipoma10.0S100A1
28renal cell carcinoma, papillary, 110.0PRCC, TFE3
29cystadenoma10.0KRT7
30thymic carcinoma10.0KRT7
31synovial sarcoma10.0KRT7
32metanephric adenoma10.0KRT7
33ependymoma10.0VIM
34mixed cell type cancer10.0KRT7
35adenomatoid tumor10.0VIM
36alveolar soft part sarcoma10.0TFE3, VIM
37teratoma10.0KRT7
38fibromatosis10.0VIM, S100A1
39nephrogenic adenoma10.0KRT7, S100A1
40pseudomyxoma peritonei10.0KRT7
41syringoma10.0S100A1
42pneumothorax10.0FLCN, FNIP2, FNIP1
43endometrial carcinoma10.0KRT7, CA9
44fibrosarcoma10.0CA9, VIM
45leiomyoma10.0FLCN, S100A1, VIM
46spindle cell sarcoma10.0KRT7, VIM
47perineurioma10.0VIM, CLDN7
48secretory meningioma10.0KRT7, VIM
49epithelioid sarcoma10.0KRT7, VIM
50sex cord-gonadal stromal tumor10.0KRT7, VIM

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to oxyphilic adenoma

Clinical Features for Oxyphilic Adenoma

Drugs & Therapeutics for Oxyphilic Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Oxyphilic Adenoma

Anatomical Context for Oxyphilic Adenoma

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33MalaCards
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MalaCards organs/tissues related to Oxyphilic Adenoma:

33
Thyroid, Salivary gland, Ovary

Animal Models for Oxyphilic Adenoma or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Oxyphilic Adenoma

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51PubMed
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Articles related to Oxyphilic Adenoma:

(show all 13)
idTitleAuthorsYear
1
Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. (17197891)
2007
2
Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. (17257073)
2006
3
Oxyphilic cell adenoma of parathyroid resulting in primary hyperparathyroidism and osteitis fibrosa cystica--a case report. (17001919)
2006
4
A peculiar Factor VIII-related antigen staining of an oxyphilic cell nodule within an intrathyroidal parathyroid adenoma. (10338086)
1999
5
Oxyphilic parathyroid adenoma and lithium therapy. (9759787)
1998
6
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. (3927580)
1985
7
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. (674638)
1978
8
The angiographic appearance of benign renal oxyphilic adenoma. (973655)
1976
9
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. (4118915)
1973
10
Oxyphilic adenoma of the larynx. (5027594)
1972
11
Onkocytoma (oxyphilic adenoma) of the caruncle. (6036309)
1967
12
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. (14310177)
1965
13
Oxyphilic adenoma of the parotid gland; report of a case. (13172681)
1954

Genetic Variations for Oxyphilic Adenoma

Expression for genes affiliated with Oxyphilic Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Oxyphilic Adenoma

Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for genes affiliated with Oxyphilic Adenoma

Compounds for genes affiliated with Oxyphilic Adenoma

Sources:
45Novoseek
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Compounds related to Oxyphilic Adenoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12-methoxyethanol459.8VIM, S100A1
2toluidine459.6S100A1, VIM
3reticulin459.4KRT7, VIM
4mucicarmine459.3KRT7, S100A1, VIM
5b 723459.2KRT7, S100A1, VIM
6hematoxylin459.1KRT7, S100A1, VIM
7paraffin458.5VIM, PVALB, CA9, S100A1, KRT7

GO Terms for genes affiliated with Oxyphilic Adenoma

Sources:
16Gene Ontology
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Biological processes related to Oxyphilic Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of pro-B cell differentiationGO:200097310.1FNIP1, FLCN
2calcium-independent cell-cell adhesionGO:01633810.0CLDN7, CLDN8
3TOR signaling cascadeGO:03192910.0FNIP1, FLCN
4negative regulation of TOR signaling cascadeGO:0320079.8FNIP1, FLCN
5regulation of protein phosphorylationGO:0019329.7FNIP1, FNIP2, FLCN
6negative regulation of transcription from RNA polymerase II promoterGO:0001228.7S100A1, UBE2D3, FLCN, FNIP2, FNIP1

Products for genes affiliated with Oxyphilic Adenoma

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Sources for Oxyphilic Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet