Aliases & Classifications for Oxyphilic Adenoma

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Aliases & Descriptions for Oxyphilic Adenoma:

Name: Oxyphilic Adenoma 11 13 68
Oncocytoma 11 50
Follicular Adenoma, Oxyphilic Cell 11
 
Hurthle Cell Tumor 68
Adenoma, Oxyphilic 39
Oncocytic Neoplasm 68

Characteristics:

HPO:

64

Classifications:



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Disease Ontology11 DOID:5389
MeSH39 D018249
SNOMED-CT62 89439007
NCIt45 C3759

Summaries for Oxyphilic Adenoma

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MalaCards based summary: Oxyphilic Adenoma, also known as oncocytoma, is related to renal oncocytoma and familial renal oncocytoma, and has symptoms including abnormality of metabolism/homeostasis and neoplasm. An important gene associated with Oxyphilic Adenoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways are TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include salivary gland and thyroid, and related mouse phenotypes are neoplasm and liver/biliary system.

Related Diseases for Oxyphilic Adenoma

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Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma12.4
2familial renal oncocytoma12.0
3birt-hogg-dube syndrome10.8
4thyroid hurthle cell adenoma10.8
5renal cell carcinoma10.5
6chromophobe renal cell carcinoma10.4
7generalized eruptive keratoacanthoma10.3AMACR, MME
8mucinous adenofibroma10.3AMACR, PAX2
9kallmann syndrome10.3MME, PAX2
10superficial urinary bladder cancer10.3AMACR, PAX2
11complement deficiency10.3FH, FLCN
12intrahepatic bile duct adenoma10.3MME, SYP
13adenoma10.3
14glomus tumor10.2KIT, SYP
15ampullary signet ring cell adenocarcinoma10.2MME, SYP
16paranasal sinus cancer10.2KIT, MME
17renal clear cell carcinoma10.2FH, FLCN
18monkeypox10.2KIT, SYP
19sphenoid sinus squamous cell carcinoma10.2KIT, MME
20ovarian germ cell teratoma10.2KIT, SYP
21intracranial sinus thrombosis10.2KIT, VIM
22marfanoid hypermobility syndrome10.2KIT, VIM
23progressive multifocal leukoencephalopathy10.2AMACR, VIM
24rectum leiomyoma10.2KIT, SYP
25congenital pulmonary airway malformation10.2LGALS3, PAX2
26rectal neoplasm10.2KIT, MME
27thyrotoxic periodic paralysis 210.2FH, FLCN
28colon signet ring adenocarcinoma10.2AMACR, KIT, PAX2
29bladder adenocarcinoma10.2PAX2, VIM
30jejunal neuroendocrine tumor10.2SYP, VIM
31myxopapillary ependymoma10.2SYP, VIM
32lymphangiosarcoma10.2MME, VIM
33autosomal recessive stickler syndrome10.2SYP, VIM
34cranial nerve disease10.2KIT, MME, PAX2
35microinvasive cervical squamous cell carcinoma10.2SYP, VIM
36adult central nervous system primitive neuroectodermal neoplasm10.2SYP, VIM
37nephrogenic adenoma of urinary bladder10.2SYP, VIM
38fragile x-associated tremor/ataxia syndrome10.2KIT, SYP
39factitious disorder10.1KIT, MME, SYP
40behcet's syndrome arthropathy10.1SYP, VIM
41arthus reaction10.1KIT, MME, SYP
42alcohol-induced mental disorder10.1KIT, VIM
43endocrine organ benign neoplasm10.1KIT, MME, SYP
44aneurysm of sinus of valsalva10.1SYP, VIM
45male reproductive system disease10.1SYP, VIM
46trachea sarcoma10.1MME, PAX2, SYP
47mucinous tubular and spindle renal cell carcinoma10.1AMACR, MME, VIM
48malignant pleural solitary fibrous tumor10.1KIT, MME, SYP
49hypogonadotropic hypogonadism-retinitis pigmentosa syndrome10.1SYP, VIM
50retinal vein occlusion10.1CDH16, FLCN, KIT, MME

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to oxyphilic adenoma

Symptoms & Phenotypes for Oxyphilic Adenoma

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Human phenotypes related to Oxyphilic Adenoma:

 64
id Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis64 HP:0001939
2 neoplasm64 HP:0002664

MGI Mouse Phenotypes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5FLCN, KIT, LGALS3, MT-ND6, RASSF1
2MP:00053708.3AMACR, KIT, KRT8, LGALS3, MME, RASSF1
3MP:00053847.6FH, FLCN, KIT, LGALS3, MT-ND6, PAX2
4MP:00053857.6FLCN, KIT, KRT8, LGALS3, MT-ND6, PAX2
5MP:00053766.9AMACR, FH, FLCN, KIT, KRT8, LGALS3

Drugs & Therapeutics for Oxyphilic Adenoma

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Drugs for Oxyphilic Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Technetium Tc 99m Sestamibi38
2Radiopharmaceuticals514

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney CancerRecruitingNCT01767636Phase 2
2Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of SamplesCompletedNCT00001814
3Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal OncocytomaRecruitingNCT02160925
4Evaluation of Diagnostic Value of Molecular Markers in Renal CancerTerminatedNCT00491621

Search NIH Clinical Center for Oxyphilic Adenoma


Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oxyphilic Adenoma

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Anatomical Context for Oxyphilic Adenoma

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MalaCards organs/tissues related to Oxyphilic Adenoma:

36
Salivary gland, Thyroid

Publications for Oxyphilic Adenoma

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Articles related to Oxyphilic Adenoma:

idTitleAuthorsYear
1
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. (3927580)
1985
2
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. (674638)
1978
3
The angiographic appearance of benign renal oxyphilic adenoma. (973655)
1976
4
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. (4118915)
1973
5
Oxyphilic adenoma of the larynx. (5027594)
1972
6
Onkocytoma (oxyphilic adenoma) of the caruncle. (6036309)
1967
7
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. (14310177)
1965
8
Oxyphilic adenoma of the parotid gland; report of a case. (13172681)
1954

Variations for Oxyphilic Adenoma

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Clinvar genetic disease variations for Oxyphilic Adenoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MT-ND6NC_ 012920.1: m.14248dupCduplicationPathogenicrs869312882GRCh37Chr MT, 14248: 14248

Expression for genes affiliated with Oxyphilic Adenoma

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Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for genes affiliated with Oxyphilic Adenoma

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GO Terms for genes affiliated with Oxyphilic Adenoma

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Cellular components related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:00443069.8MME, SYP

Biological processes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of programmed cell deathGO:004306910.2KIT, PAX2
2stem cell differentiationGO:00488639.8KIT, PAX2

Sources for Oxyphilic Adenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet