Aliases & Classifications for Oxyphilic Adenoma

Aliases & Descriptions for Oxyphilic Adenoma:

Name: Oxyphilic Adenoma 12 14 69
Oncocytoma 12 52
Follicular Adenoma, Oxyphilic Cell 12
Adenoma, Oxyphilic 42
Hurthle Cell Tumor 69
Oncocytic Neoplasm 69

Characteristics:

HPO:

32
oxyphilic adenoma:
Inheritance mitochondrial inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:5389
MeSH 42 D018249
NCIt 47 C3759
SNOMED-CT 64 89439007
UMLS 69 C1510502

Summaries for Oxyphilic Adenoma

MalaCards based summary : Oxyphilic Adenoma, also known as oncocytoma, is related to renal oncocytoma and familial renal oncocytoma, and has symptoms including abnormality of metabolism/homeostasis and neoplasm. An important gene associated with Oxyphilic Adenoma is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Technetium Tc 99m Sestamibi and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include thyroid and salivary gland, and related phenotypes are cardiovascular system and cellular

Related Diseases for Oxyphilic Adenoma

Diseases related to Oxyphilic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Related Disease Score Top Affiliating Genes
1 renal oncocytoma 12.4
2 familial renal oncocytoma 12.0
3 birt-hogg-dube syndrome 10.8
4 thyroid hurthle cell adenoma 10.8
5 renal cell carcinoma 10.5
6 chromophobe renal cell carcinoma 10.4
7 generalized eruptive keratoacanthoma 10.3 AMACR MME
8 mucinous adenofibroma 10.3 AMACR PAX2
9 kallmann syndrome 10.3 MME PAX2
10 superficial urinary bladder cancer 10.3 AMACR PAX2
11 complement deficiency 10.3 FH FLCN
12 intrahepatic bile duct adenoma 10.3 MME SYP
13 adenoma 10.3
14 glomus tumor 10.2 KIT SYP
15 ampullary signet ring cell adenocarcinoma 10.2 MME SYP
16 paranasal sinus cancer 10.2 KIT MME
17 renal clear cell carcinoma 10.2 FH FLCN
18 monkeypox 10.2 KIT SYP
19 sphenoid sinus squamous cell carcinoma 10.2 KIT MME
20 ovarian germ cell teratoma 10.2 KIT SYP
21 intracranial sinus thrombosis 10.2 KIT VIM
22 marfanoid hypermobility syndrome 10.2 KIT VIM
23 progressive multifocal leukoencephalopathy 10.2 AMACR VIM
24 rectum leiomyoma 10.2 KIT SYP
25 congenital pulmonary airway malformation 10.2 LGALS3 PAX2
26 rectal neoplasm 10.2 KIT MME
27 thyrotoxic periodic paralysis 2 10.2 FH FLCN
28 colon signet ring adenocarcinoma 10.2 AMACR KIT PAX2
29 bladder adenocarcinoma 10.2 PAX2 VIM
30 jejunal neuroendocrine tumor 10.2 SYP VIM
31 myxopapillary ependymoma 10.2 SYP VIM
32 lymphangiosarcoma 10.2 MME VIM
33 autosomal recessive stickler syndrome 10.2 SYP VIM
34 cranial nerve disease 10.2 KIT MME PAX2
35 microinvasive cervical squamous cell carcinoma 10.2 SYP VIM
36 adult central nervous system primitive neuroectodermal neoplasm 10.2 SYP VIM
37 nephrogenic adenoma of urinary bladder 10.2 SYP VIM
38 fragile x-associated tremor/ataxia syndrome 10.2 KIT SYP
39 factitious disorder 10.1 KIT MME SYP
40 behcet's syndrome arthropathy 10.1 SYP VIM
41 arthus reaction 10.1 KIT MME SYP
42 alcohol-induced mental disorder 10.1 KIT VIM
43 endocrine organ benign neoplasm 10.1 KIT MME SYP
44 aneurysm of sinus of valsalva 10.1 SYP VIM
45 male reproductive system disease 10.1 SYP VIM
46 trachea sarcoma 10.1 MME PAX2 SYP
47 mucinous tubular and spindle renal cell carcinoma 10.1 AMACR MME VIM
48 malignant pleural solitary fibrous tumor 10.1 KIT MME SYP
49 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.1 SYP VIM
50 retinal vein occlusion 10.1 CDH16 FLCN KIT MME

Graphical network of the top 20 diseases related to Oxyphilic Adenoma:



Diseases related to Oxyphilic Adenoma

Symptoms & Phenotypes for Oxyphilic Adenoma

Human phenotypes related to Oxyphilic Adenoma:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 neoplasm 32 HP:0002664

MGI Mouse Phenotypes related to Oxyphilic Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 FLCN KIT KRT8 LGALS3 MT-ND6 PAX2
2 cellular MP:0005384 9.91 FH FLCN KIT LGALS3 MT-ND6 PAX2
3 homeostasis/metabolism MP:0005376 9.85 RASSF1 VIM AMACR FH FLCN KIT
4 liver/biliary system MP:0005370 9.43 AMACR KIT KRT8 LGALS3 MME RASSF1
5 neoplasm MP:0002006 9.02 FLCN KIT LGALS3 MT-ND6 RASSF1

Drugs & Therapeutics for Oxyphilic Adenoma

Drugs for Oxyphilic Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Technetium Tc 99m Sestamibi
2 Radiopharmaceuticals

Interventional clinical trials:


id Name Status NCT ID Phase
1 Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Recruiting NCT01767636 Phase 2
2 Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples Completed NCT00001814
3 Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal Oncocytoma Recruiting NCT02160925
4 Evaluation of Diagnostic Value of Molecular Markers in Renal Cancer Terminated NCT00491621

Search NIH Clinical Center for Oxyphilic Adenoma

Cochrane evidence based reviews: adenoma, oxyphilic

Genetic Tests for Oxyphilic Adenoma

Anatomical Context for Oxyphilic Adenoma

MalaCards organs/tissues related to Oxyphilic Adenoma:

39
Thyroid, Salivary Gland

Publications for Oxyphilic Adenoma

Articles related to Oxyphilic Adenoma:

id Title Authors Year
1
Ultrastructural study of glycogen-rich oxyphilic adenoma of the nasopharyngeal minor salivary gland. ( 3927580 )
1985
2
Oxyphilic adenoma of the parotid gland. Identification with 99mTc-pertechnetate. ( 674638 )
1978
3
The angiographic appearance of benign renal oxyphilic adenoma. ( 973655 )
1976
4
Oxyphilic adenoma of the human thyroid. A morphological and biochemical study. ( 4118915 )
1973
5
Oxyphilic adenoma of the larynx. ( 5027594 )
1972
6
Onkocytoma (oxyphilic adenoma) of the caruncle. ( 6036309 )
1967
7
OXYPHILIC ADENOMA (ONCOCYTOMA) OF THE LARYNX; PRESENTATION OF A CASE. ( 14310177 )
1965
8
Oxyphilic adenoma of the parotid gland; report of a case. ( 13172681 )
1954

Variations for Oxyphilic Adenoma

ClinVar genetic disease variations for Oxyphilic Adenoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MT-ND6 NC_012920.1: m.14248dupC duplication Pathogenic rs869312882 GRCh37 Chromosome MT, 14248: 14248

Expression for Oxyphilic Adenoma

Search GEO for disease gene expression data for Oxyphilic Adenoma.

Pathways for Oxyphilic Adenoma

Pathways related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.03 PAX2 SYP VIM
2 10.79 KRT8 MME PAX2 VIM
3 10.41 CDH16 VIM

GO Terms for Oxyphilic Adenoma

Cellular components related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 MME SYP

Biological processes related to Oxyphilic Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 8.96 KIT PAX2
2 negative regulation of programmed cell death GO:0043069 8.62 KIT PAX2

Sources for Oxyphilic Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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