MCID: PCH015
MIFTS: 49

Pachyonychia Congenita 1 malady

Categories: Genetic diseases, Rare diseases, Skin diseases, Fetal diseases

Aliases & Classifications for Pachyonychia Congenita 1

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 26GTR, 30ICD10 via Orphanet, 36MedGen, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Pachyonychia Congenita 1:

Name: Pachyonychia Congenita 1 51 69
Pachyonychia Congenita 11 23 47 24 25 53 38 13 67
Pachyonychia Congenita Syndrome 47 25 26
Pachyonychia Congenita, Jadassohn-Lewandowsky Type 11 12
Jadassohn-Lewandowsky Syndrome 11 69
Pachyonychia Congenita Type 1 11 26
Congenital Pachyonychia 47 25
Pachyonychia Congenita, Jadassohn Lewandowsky Type 67
Pachyonychia Congenita Jadassohn-Lewandowsky Type 69
 
Jackson-Lawler Type Pachyonychia Congenita 11
Pyruvate Carboxylase Deficiency Disease 67
Jadassohn-Lewandowski Syndrome 25
Pachyonychia Congenita, Type 2 67
Pachyonychia Congenita, Type 1 49
Jackson-Lawler Syndrome 25
Pc1 69
Pc 53

Characteristics:

Orphanet epidemiological data:

53
pachyonychia congenita:
Inheritance: Autosomal dominant; Age of onset: All ages; Age of death: normal life expectancy

HPO:

63
pachyonychia congenita 1:
Inheritance: autosomal dominant inheritance, heterogeneous

GeneReviews:

23
Penetrance: within families studied to date, inheritance of a pathogenic variant is uniformly associated with some manifestation of disease, suggesting that penetrance is 100%...


Classifications:



External Ids:

OMIM51 167200
Disease Ontology11 DOID:0050449
MeSH38 D053549
NCIt44 C84986
Orphanet53 ORPHA2309
SNOMED-CT61 205600001, 39427000
MESH via Orphanet39 D053549
UMLS via Orphanet68 C0265334
ICD10 via Orphanet30 Q84.5
MedGen36 C1706595

Summaries for Pachyonychia Congenita 1

About this section
OMIM:51 Pachyonychia congenita (PC) is an autosomal dominant genodermatosis with the main clinical features of hypertrophic... (167200) more...

MalaCards based summary: Pachyonychia Congenita 1, also known as pachyonychia congenita, is related to pachyonychia congenita 2 and pachyonychia congenita 4, and has symptoms including hyperhidrosis, palmoplantar keratoderma and abnormality of the fingernails. An important gene associated with Pachyonychia Congenita 1 is KRT16 (Keratin 16), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. Affiliated tissues include skin, prostate and kidney, and related mouse phenotype digestive/alimentary.

UniProtKB/Swiss-Prot:69 Pachyonychia congenita 1: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.

Genetics Home Reference:25 Pachyonychia congenita is a condition that primarily affects the nails and skin. The signs and symptoms of this condition usually become apparent within the first few months of life.

Wikipedia:70 Pachyonychia congenita is an autosomal dominant skin disorder. more...

GeneReviews for NBK1280

Related Diseases for Pachyonychia Congenita 1

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Diseases in the Pachyonychia Congenita 1 family:

Pachyonychia Congenita 3 Pachyonychia Congenita 4
Pachyonychia Congenita 2 Krt16-Related Pachyonychia Congenita
Krt17-Related Pachyonychia Congenita Krt6a-Related Pachyonychia Congenita
Krt6b-Related Pachyonychia Congenita

Diseases related to Pachyonychia Congenita 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1pachyonychia congenita 233.7KRT16, KRT17, KRT6A, KRT6B
2pachyonychia congenita 412.4
3pachyonychia congenita 312.4
4krt16-related pachyonychia congenita11.9
5krt17-related pachyonychia congenita11.9
6krt6a-related pachyonychia congenita11.9
7krt6b-related pachyonychia congenita11.9
8steatocystoma multiplex11.4
9obesity with impaired prohormone processing10.8
10otosclerosis10.5KRT16, KRT17
11abnormal pupillary function10.5KRT16, KRT6A
12cholesteatoma of attic10.4KRT6A, KRT6B
13ichthyosis histrix, curth-macklin type10.4KRT10, KRT16
14sclerosteosis 110.4KRT16, KRT17, KRT6B
15epidermolytic acanthoma10.3KRT10, KRT17
16ebola hemorrhagic fever10.3KRT10, KRT9
17hypothyroidism10.3KRT16, KRT6A, KRT6B
18metatypical basal cell carcinoma10.3KRT10, KRT17
19keratosis palmoplantaris striata iii10.3KRT16, KRT17, KRT9
20hemoglobin d disease10.3KRT10, KRT17
21complex lethal osteochondrodysplasia10.3KRT10, KRT16
22laryngitis10.2
23craniodiaphyseal dysplasia, autosomal dominant10.2KRT10, KRT16, KRT17
24telangiectasia, hereditary hemorrhagic, type 210.2KRT10, KRT2
25familial retinoblastoma10.1KRT10, KRT16, KRT17
26colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.1KRT10, KRT17
27bullous keratopathy10.1KRT10, KRT16
28alopecia10.1
29palmoplantar keratoderma, epidermolytic10.0KRT16, KRT74, KRT9
30hidradenitis10.0
31cryptosporidiosis10.0FLG, KRT17
32neuronitis10.0
33rectosigmoid junction neoplasm9.9FLG, KRT16
34thyroiditis9.9
35ewing sarcoma9.9
36b-cell lymphomas9.9
37skin disease9.9
38lymphoma9.9
39sarcoma9.9
40fissured tongue9.9
41patent ductus arteriosus9.9
42median rhomboid glossitis9.9
43glossitis9.9
44candidiasis9.9
45cheilitis9.9
46corneal dystrophy9.9
47dermatitis9.9
48epidermolysis bullosa9.9
49atopic dermatitis9.9
50epidermolysis bullosa simplex9.9

Graphical network of the top 20 diseases related to Pachyonychia Congenita 1:



Diseases related to pachyonychia congenita 1

Symptoms for Pachyonychia Congenita 1

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Symptoms by clinical synopsis from OMIM:

167200

Clinical features from OMIM:

167200

Human phenotypes related to Pachyonychia Congenita 1:

 63 53 (show all 25)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis63 53 hallmark (90%) Very frequent (99-80%) HP:0000975
2 palmoplantar keratoderma63 53 hallmark (90%) Very frequent (99-80%) HP:0000982
3 abnormality of the fingernails63 53 hallmark (90%) Occasional (29-5%) HP:0001231
4 abnormality of the toenails63 hallmark (90%) HP:0008388
5 abnormality of nail color63 53 hallmark (90%) Very frequent (99-80%) HP:0100643
6 carious teeth63 53 typical (50%) Frequent (79-30%) HP:0000670
7 anonychia63 53 typical (50%) Occasional (29-5%) HP:0001798
8 ichthyosis63 53 typical (50%) Frequent (79-30%) HP:0008064
9 abnormal blistering of the skin63 53 typical (50%) Frequent (79-30%) HP:0008066
10 neoplasm of the skin63 typical (50%) HP:0008069
11 cataract63 53 occasional (7.5%) Occasional (29-5%) HP:0000518
12 corneal dystrophy63 53 occasional (7.5%) Occasional (29-5%) HP:0001131
13 alopecia63 53 occasional (7.5%) Occasional (29-5%) HP:0001596
14 laryngomalacia63 53 occasional (7.5%) Occasional (29-5%) HP:0001601
15 respiratory insufficiency63 53 occasional (7.5%) Occasional (29-5%) HP:0002093
16 hepatomegaly63 53 occasional (7.5%) Occasional (29-5%) HP:0002240
17 cognitive impairment63 53 occasional (7.5%) Occasional (29-5%) HP:0100543
18 palmoplantar hyperkeratosis63 HP:0000972
19 thick nail63 53 Very frequent (99-80%) HP:0001805
20 oral leukoplakia63 53 Very frequent (99-80%) HP:0002745
21 follicular hyperkeratosis63 HP:0007502
22 abnormality of the teeth53 Frequent (79-30%)
23 abnormality of the hair53 Very frequent (99-80%)
24 abnormality of the nail53 Very frequent (99-80%)
25 nail dystrophy53 Very frequent (99-80%)

UMLS symptoms related to Pachyonychia Congenita 1:


clonus, hepatomegaly, seizures, hoarseness

Drugs & Therapeutics for Pachyonychia Congenita 1

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Drugs for Pachyonychia Congenita 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 53)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 3, Phase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2AntimetabolitesPhase 3, Phase 211774
3Anti-Infective AgentsPhase 3, Phase 2, Phase 121402
4Immunosuppressive AgentsPhase 3, Phase 2, Phase 112770
5Antimetabolites, AntineoplasticPhase 3, Phase 27171
6Antiviral AgentsPhase 3, Phase 29732
7
AcetylcholineapprovedPhase 277651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
8
Miconazoleapproved, investigational, vet_approvedPhase 2, Phase 1362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
9
EverolimusapprovedPhase 2, Phase 11896159351-69-66442177
Synonyms:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy
07741_FLUKA
159351-69-6
40-O-(2-hydroxyethyl)-rapamycin
42-O-(2-Hydroxyethyl)rapamycin
Afinitor
CERTICAN(R)
CHEMBL1201755
Certican
D02714
DB01590
 
Everolimus
Everolimus (JAN/USAN/INN)
Everolimus [USAN]
LS-143292
MolPort-003-847-342
MolPort-003-925-588
NCGC00167512-01
NVP-RAD-001
RAD 001
RAD-001
RAD-001C
RAD001
RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus
S1120_Selleck
SDZ-RAD
UNII-9HW64Q8G6G
Zortress
everolimus
10
Heparinapproved, investigationalPhase 28129005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
11
Paclitaxelapproved, vet_approvedPhase 2275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
12
Sirolimusapproved, investigationalPhase 2, Phase 1189653123-88-95284616, 6436030, 46835353
Synonyms:
(-)-Rapamycin
(-)-rapamycin
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29
3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
53123-88-9
A422989, NSC226080
AC-722
AC1L1JH9
AC1L7MJ9
AC1L9ZMV
AY 22989
AY-22989
AY22989
Ambotz53123-88-9
Antibiotic AY 22989
BIDD:PXR0165
Bio1_000293
Bio1_000782
Bio1_001271
Bio2_000375
Bio2_000855
BiomolKI2_000084
C07909
C51H79NO13
CBiol_002007
CCRIS 9024
CHEBI:100923
CHEBI:9168
CHEMBL413
CID10213190
CID10795871
CID11949238
CID11959112
CID313006
CID478951
CID5040
CID5284616
CID5358081
CID5374464
CID5460439
CID5497196
CID5924240
CID6436030
CID6610270
CID6610346
CID6711160
CID6713081
CID9833581
CID9854379
CID9854380
CID9962926
CID9962928
D00753
DB00877
DE-109
DivK1c_006936
 
FT-0082351
HMS2089A21
HSDB 7284
KBio1_001880
KBio2_000410
KBio2_002978
KBio2_005546
KBio3_000779
KBio3_000780
KBioGR_000410
KBioSS_000410
LCP-Siro
LMPK06000003
LS-143290
MLS000028373
MS-R001
MolMap_000043
MolPort-003-959-433
NCGC00021305-05
NCI60_001851
NCIMech_000355
NSC 226080
NSC226080
Perceiva
QTL1_000069
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RPM
Rapammune
Rapamune
Rapamune (TN)
Rapamycin
Rapamycin (TN)
Rapamycin C-7, analog 4
Rapamycin Immunosuppressant Drug
Rapamycin from Streptomyces hygroscopicus
S1039_Selleck
SIIA 9268A
SILA 9268A
SILA9268A
SMP1_000255
SMR000058564
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus (USAN/INN)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
SpecPlus_000840
UNII-W36ZG6FT64
UNM-0000358684
WY-090217
Wy 090217
heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
rapamycin
sirolimus
13
Radium Ra 223 dichlorideapproved, investigationalPhase 254444811-40-9
Synonyms:
Radium-223 chloride
 
Radium-223 dichloride
Xofigo
14
SuccinylcholineapprovedPhase 2161306-40-15314
Synonyms:
2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM)
2,2'-[(1,4-DIOXOBUTANE-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
2ha2
2ha6
306-40-1
4-04-00-01451 (Beilstein Handbook Reference)
541-19-5 (diiodide)
55-94-7 (dibromide)
71-27-2 (dichloride)
AC1L1K2T
Anectine
BRN 1805311
C07546
C14H30N2O4
CHEBI:45652
CHEMBL703
CID5314
Choline, succinate (2:1) (ester)
Choline, succinate (ester)
DB00202
Diacetylcholine
Dicholine succinate
Ditilin
Ditiline
HMS2090P14
HSDB 3254
InChI=1/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
L000926
LS-53328
Listenon
 
Lopac-S-8251
Lopac0_001080
Lysthenon
MolPort-002-964-486
NCGC00015971-01
NCGC00015971-03
NCGC00162336-01
Quelicin
Quelicin Preservative Free
SCK
ST50437287
STK177290
Scoline
Succicuran
Succinic acid, diester with choline
Succinic acid, diester with choline chloride
Succinocholine
Succinoylcholine
Succinyl choline
Succinylbischoline
Succinylcholine
Succinylcholine Chloride
Succinyldicholine
Sucostrin
Suxamethonium
Suxamethonium chloride
UNII-J2R869A8YF
ZINC01530820
succinylcholine
succinyldicholine
trimethyl-[2-[4-oxo-4-(2-trimethylazaniumylethoxy)butanoyl]oxyethyl]azanium diio
trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium
15incobotulinumtoxinAPhase 2635
16AnestheticsPhase 29001
17Cholinergic AgentsPhase 2, Phase 13846
18Botulinum ToxinsPhase 2669
19Botulinum Toxins, Type APhase 2630
20abobotulinumtoxinAPhase 2626
21Neurotransmitter AgentsPhase 2, Phase 117734
22Neuromuscular AgentsPhase 21129
23Peripheral Nervous System AgentsPhase 2, Phase 122776
24onabotulinumtoxinAPhase 2626
25Pharmaceutical SolutionsPhase 2, Phase 17793
26Antineoplastic Agents, PhytogenicPhase 25420
27calcium heparinPhase 2812
28Antimitotic AgentsPhase 25498
29Fibrinolytic AgentsPhase 22317
30Calcium, DietaryPhase 25525
31ImmunoglobulinsPhase 26045
32AntibodiesPhase 26045
33AnticoagulantsPhase 22516
34Antibiotics, AntitubercularPhase 2, Phase 16972
35Anti-Bacterial AgentsPhase 2, Phase 110884
36Albumin-Bound PaclitaxelPhase 22757
37Antihypertensive AgentsPhase 24095
38Antifungal AgentsPhase 2, Phase 13615
39Neuromuscular Blocking AgentsPhase 2414
40Neuromuscular Depolarizing AgentsPhase 2135
41
NicotineapprovedPhase 1105054-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-(−)-nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(−)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-(N-methylpyrollidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L(−)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
42Nicotinic AgonistsPhase 1902
43Central Nervous System StimulantsPhase 12132
44Autonomic AgentsPhase 19774
45
Simvastatinapproved51079902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
46Hypolipidemic Agents2721
47Lipid Regulating Agents2702
48Hydroxymethylglutaryl-CoA Reductase Inhibitors1956
49Anticholesteremic Agents1983
50Insulin, Globin Zinc4523

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Multi-center Clinical Evaluation of PC 1-Day vs 1-Day Acuvue MoistCompletedNCT02024698Phase 4
2A Study of Nimotuzumab Combinated With Gemcitabine in K-RAS Wild-type Locally Advanced and Metastatic Pancreatic CancerRecruitingNCT02395016Phase 3
3Botulinumtoxin A Treatment in Epidermolysis Bullosa Simplex and Pachyonychia CongenitaUnknown statusNCT00936533Phase 2
4An Open, Single-center Study to Determine the Antibody Repsonse to Gastrimmune and Its Safety and Tolerability in Patients With Advanced Pancreatic CarcinomaCompletedNCT02098291Phase 2
5Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and SafetyCompletedNCT00491517Phase 2
6Efficacy & Safety of ODSH (2-0, 3-0 Desulfated Heparin) in Patients With Metastatic Pancreatic Cancer Treated With Gemcitabine & AbraxaneCompletedNCT01461915Phase 2
7uPAR PET/CT in Radium-223-dichloride Treatment of Patients With Metastatic Castration-resistant Prostate CancerRecruitingNCT02964988Phase 2
8Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia CongenitaCompletedNCT00716014Phase 1
9Topical Sirolimus for the Treatment of Pachyonychia Congenita (PC)CompletedNCT02152007Phase 1
10Pilot Pharmacokinetic Study of New Nicotine Lozenge FormulationsCompletedNCT01574898Phase 1
11Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal SkinRecruitingNCT02592954Phase 1
12Polarized Reflectance Spectroscopy for Oral LesionsRecruitingNCT01604759Phase 1
13Simvastatin Treatment of Pachyonychia CongenitaUnknown statusNCT01382511
14National Registry for Ichthyosis and Related DisordersUnknown statusNCT00074685
15Proclear 1-D Multifocal Nondispensing StudyCompletedNCT01526902
16The Role of Small Intestinal Endocrine Cells in Type 2 Diabetic HyperglucagonemiaCompletedNCT00639613
17Different Training (Aerobic, Resistance or Mixed) Physical Programs Affect to Physiological Responses (TRAINING2014)CompletedNCT02441192
18International Pachyonychia Congenita Research RegistryRecruitingNCT02321423
19ProstaCare Study for BPHRecruitingNCT02962674

Search NIH Clinical Center for Pachyonychia Congenita 1


Cochrane evidence based reviews: pachyonychia congenita

Genetic Tests for Pachyonychia Congenita 1

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Genetic tests related to Pachyonychia Congenita 1:

id Genetic test Affiliating Genes
1 Pachyonychia Congenita, Type 126
2 Pachyonychia Congenita Syndrome26
3 Pachyonychia Congenita24 KRT6B

Anatomical Context for Pachyonychia Congenita 1

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MalaCards organs/tissues related to Pachyonychia Congenita 1:

35
Skin, Prostate, Kidney, Small intestine

Animal Models for Pachyonychia Congenita 1 or affiliated genes

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MGI Mouse Phenotypes related to Pachyonychia Congenita 1:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6KRT16, KRT17, KRT6B, PCSK5, SLURP1

Publications for Pachyonychia Congenita 1

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Variations for Pachyonychia Congenita 1

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UniProtKB/Swiss-Prot genetic disease variations for Pachyonychia Congenita 1:

69 (show all 14)
id Symbol AA change Variation ID SNP ID
1KRT16p.Leu132ProVAR_003846rs60944949
2KRT16p.Asn125SerVAR_009183rs60723330
3KRT16p.Arg127CysVAR_009184rs59856285
4KRT16p.Gln122ProVAR_012855rs59349773
5KRT16p.Arg127ProVAR_012856rs57424749
6KRT16p.Leu124ArgVAR_013837rs58293603
7KRT16p.Met121ThrVAR_017065rs28928894
8KRT16p.Leu128GlnVAR_017066rs28928895
9KRT16p.Lys354AsnVAR_017067rs59328451
10KRT16p.Leu124HisVAR_072436rs58293603
11KRT16p.Leu124ProVAR_072437rs58293603
12KRT16p.Asn125AspVAR_072438rs58608173
13KRT16p.Asn125GlyVAR_072439rs587777717
14KRT16p.Leu421ProVAR_072440

Clinvar genetic disease variations for Pachyonychia Congenita 1:

5 (show all 41)
id Gene Variation Type Significance SNP ID Assembly Location
1KRT17NM_000422.2(KRT17): c.274A> G (p.Asn92Asp)SNVPathogenicrs28928896GRCh37Chr 17, 39780488: 39780488
2KRT17NM_000422.2(KRT17): c.275A> G (p.Asn92Ser)SNVPathogenicrs59151893GRCh37Chr 17, 39780487: 39780487
3KRT17NM_000422.2(KRT17): c.292T> G (p.Tyr98Asp)SNVPathogenicrs28933088GRCh37Chr 17, 39780470: 39780470
4KRT17NM_000422.2(KRT17): c.281G> A (p.Arg94His)SNVPathogenicrs28928897GRCh37Chr 17, 39780481: 39780481
5KRT17NM_000422.2(KRT17): c.280C> T (p.Arg94Cys)SNVPathogenicrs58730926GRCh37Chr 17, 39780482: 39780482
6KRT17NM_000422.2(KRT17): c.263T> C (p.Met88Thr)SNVPathogenicrs28928898GRCh37Chr 17, 39780499: 39780499
7KRT17NM_000422.2(KRT17): c.281_295delGCCTGGCCTCCTACC (p.Arg94_Tyr98del)deletionPathogenicrs57674130GRCh37Chr 17, 39780467: 39780481
8KRT17NM_000422.2(KRT17): c.281G> C (p.Arg94Pro)SNVPathogenicrs28928897GRCh37Chr 17, 39780481: 39780481
9KRT17NM_000422.2(KRT17): c.284T> A (p.Leu95Gln)SNVPathogenicrs28928899GRCh37Chr 17, 39780478: 39780478
10KRT17NM_000422.2(KRT17): c.284T> C (p.Leu95Pro)SNVPathogenicrs28928899GRCh37Chr 17, 39780478: 39780478
11KRT17NM_000422.2(KRT17): c.296T> C (p.Leu99Pro)SNVPathogenicrs28933089GRCh37Chr 17, 39780466: 39780466
12KRT17NM_000422.2(KRT17): c.304G> A (p.Val102Met)SNVPathogenicrs59977263GRCh37Chr 17, 39780458: 39780458
13KRT16NM_005557.3(KRT16): c.395T> C (p.Leu132Pro)SNVPathogenicrs60944949GRCh37Chr 17, 39768546: 39768546
14KRT16NM_005557.3(KRT16): c.374A> G (p.Asn125Ser)SNVPathogenicrs60723330GRCh37Chr 17, 39768567: 39768567
15KRT16NM_005557.3(KRT16): c.389_391delCCT (p.Ser130del)deletionPathogenicrs58181827GRCh37Chr 17, 39768550: 39768552
16KRT16NM_005557.3(KRT16): c.380G> C (p.Arg127Pro)SNVPathogenicrs57424749GRCh37Chr 17, 39768561: 39768561
17KRT16NM_005557.3(KRT16): c.365A> C (p.Gln122Pro)SNVPathogenicrs59349773GRCh37Chr 17, 39768576: 39768576
18KRT16NM_005557.3(KRT16): c.371T> G (p.Leu124Arg)SNVPathogenicrs58293603GRCh37Chr 17, 39768570: 39768570
19KRT16NM_005557.3(KRT16): c.1062A> T (p.Lys354Asn)SNVPathogenicrs59328451GRCh37Chr 17, 39766801: 39766801
20KRT16NM_005557.3(KRT16): c.362T> C (p.Met121Thr)SNVPathogenicrs28928894GRCh37Chr 17, 39768579: 39768579
21KRT16NM_005557.3(KRT16): c.383T> A (p.Leu128Gln)SNVPathogenicrs28928895GRCh37Chr 17, 39768558: 39768558
22KRT16NM_005557.3(KRT16): c.373_374delAAinsGG (p.Asn125Gly)indelPathogenicrs587777717GRCh38Chr 17, 41612315: 41612316
23PCNM_000920.3(PC): c.1828G> A (p.Ala610Thr)SNVPathogenicrs28940589GRCh37Chr 11, 66619415: 66619415
24PCNM_000920.3(PC): c.2229G> T (p.Met743Ile)SNVPathogenicrs28940590GRCh37Chr 11, 66618389: 66618389
25PCNM_000920.3(PC): c.434T> C (p.Val145Ala)SNVPathogenicrs28940591GRCh37Chr 11, 66638839: 66638839
26PCNM_000920.3(PC): c.1351C> T (p.Arg451Cys)SNVPathogenicrs113994143GRCh37Chr 11, 66631262: 66631262
27PCPC, IVS15, 4-BP DEL, TAGG, +2-5deletionPathogenicChr na, -1: -1
28PCPC, 2-BP DEL, 2491GTdeletionPathogenicChr na, -1: -1
29PCNM_001040716.1(PC): c.467G> A (p.Arg156Gln)SNVPathogenicrs119103241GRCh37Chr 11, 66638806: 66638806
30PCNM_001040716.1(PC): c.1748G> T (p.Arg583Leu)SNVPathogenicrs119103242GRCh37Chr 11, 66619987: 66619987
31PCPC, 1-BP DUP, 2876TduplicationPathogenicChr na, -1: -1
32PCNM_000920.3(PC): c.1705A> G (p.Thr569Ala)SNVPathogenicrs113994144GRCh37Chr 11, 66620030: 66620030
33PCNM_000920.3(PC): c.184C> T (p.Arg62Cys)SNVPathogenicrs113994141GRCh37Chr 11, 66639295: 66639295
34PCNM_000920.3(PC): c.1892G> A (p.Arg631Gln)SNVPathogenicrs113994145GRCh37Chr 11, 66619351: 66619351
35PCNM_000920.3(PC): c.2114C> A (p.Ser705Ter)SNVPathogenicrs113994146GRCh37Chr 11, 66618620: 66618620
36PCNM_000920.3(PC): c.2540C> T (p.Ala847Val)SNVPathogenicrs113994147GRCh37Chr 11, 66617869: 66617869
37PCNM_000920.3(PC): c.3409_3410delCT (p.Leu1137Valfs)deletionPathogenicrs113994148GRCh37Chr 11, 66616497: 66616498
38PCNM_000920.3(PC): c.796T> A (p.Ser266Thr)SNVPathogenicrs113994142GRCh37Chr 11, 66637880: 66637880
39KRT16NM_005557.3(KRT16): c.365A> G (p.Gln122Arg)SNVLikely pathogenicrs59349773GRCh37Chr 17, 39768576: 39768576
40KRT17NM_000422.2(KRT17): c.290_292delCCT (p.Ser97del)deletionPathogenicrs121912478GRCh37Chr 17, 39780470: 39780472
41KRT16NM_005557.3(KRT16): c.373A> G (p.Asn125Asp)SNVPathogenicrs58608173GRCh37Chr 17, 39768568: 39768568

Expression for genes affiliated with Pachyonychia Congenita 1

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Search GEO for disease gene expression data for Pachyonychia Congenita 1.

Pathways for genes affiliated with Pachyonychia Congenita 1

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Pathways related to Pachyonychia Congenita 1 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2KRT16, KRT17, KRT2, KRT6A
29.1KRT10, KRT17, KRT6A, KRT6B

GO Terms for genes affiliated with Pachyonychia Congenita 1

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Cellular components related to Pachyonychia Congenita 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.0KRT2, KRT6A, KRT6B, KRT74, KRT75
2intermediate filamentGO:00058827.5FLG, KRT10, KRT16, KRT17, KRT2, KRT6A
3extracellular exosomeGO:00700626.7KRT10, KRT16, KRT17, KRT2, KRT6A, KRT6B

Biological processes related to Pachyonychia Congenita 1 according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1keratinocyte migrationGO:005154610.5KRT16, KRT2
2keratinizationGO:00314249.9KRT16, KRT17, KRT2
3intermediate filament cytoskeleton organizationGO:00451049.7KRT16, KRT6A, KRT74
4establishment of skin barrierGO:00614369.6FLG, KRT16
5cytoskeleton organizationGO:00070109.6KRT16, KRT2, KRT6B
6epidermis developmentGO:00085449.4KRT16, KRT17, KRT2, KRT9
7keratinocyte differentiationGO:00302169.2FLG, KRT10, KRT16
8intermediate filament organizationGO:00451099.2KRT17, KRT2, KRT9

Molecular functions related to Pachyonychia Congenita 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.6KRT16, KRT17, KRT2, KRT6A, KRT6B, KRT9
2structural molecule activityGO:00051987.8FLG, KRT2, KRT6A, KRT74, KRT75

Sources for Pachyonychia Congenita 1

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet