Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 14
Analgesia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to agnosia and increased analgesia from kappa-opioid receptor agonist, female-specific. An important gene associated with Pain Agnosia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Ketamine and Nalbuphine have been mentioned in the context of this disorder. Affiliated tissues include breast, liver and colon, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 agnosia 25.2 AP1M2 AP2M1 CCK CNR1 HTR7 LIPN
2 increased analgesia from kappa-opioid receptor agonist, female-specific 12.0
3 chronic pain requiring intraspinal analgesia 11.9
4 indifference to pain, congenital, autosomal recessive 11.0
5 neuropathy, hereditary sensory and autonomic, type v 11.0
6 marsili syndrome 10.8
7 hereditary sensory neuropathy 10.8
8 congenital insensitivity to pain with hyperhidrosis 10.8
9 congenital insensitivity to pain with severe intellectual disability 10.8
10 cyclic vomiting syndrome 10.5 CNR1 OPRM1
11 myofascial pain syndrome 10.5 POMC TAC1
12 sick building syndrome 10.5 POMC TRPV1
13 autoimmune encephalitis 10.5 CNR1 TRPV1
14 epicondylitis 10.5 LIPN TAC1
15 retrograde amnesia 10.5 PDYN POMC
16 neonatal abstinence syndrome 10.5 OPRK1 OPRM1
17 stereotypic movement disorder 10.5 CCK TAC1
18 somatoform disorder 10.5 OPRM1 TAC1 TRPV1
19 chronic pain 10.5 CNR1 OPRM1
20 trigeminal nerve disease 10.4 LIPN TAC1 TRPV1
21 pancreas disease 10.4 CCK POMC TRPV1
22 functional gastric disease 10.4 CCK HTR7 TRPV1
23 overnutrition 10.4 CNR1 POMC TRPV1
24 constipation 10.4 CCK OPRM1 TAC1
25 shipyard eye 10.4 PDYN PSENEN
26 female reproductive system disease 10.4 OXT POMC TRPV1
27 anismus 10.4 OXT TAC1
28 eating disorder 10.4 CCK CNR1 POMC
29 opioid abuse 10.4 CCK OPRM1 PDYN TRPV1
30 diverticulitis of colon 10.4 CNR1 TRPV1
31 uremic pruritus 10.4 CNR1 OPRK1
32 premenstrual tension 10.4 LIPN OXT POMC
33 mental depression 10.3 HTR7 OXT POMC
34 opiate dependence 10.3 OPRK1 OPRM1 PDYN POMC
35 cocaine dependence 10.3 OPRK1 OPRM1 PDYN POMC
36 amnestic disorder 10.3 CNR1 HTR7 PDYN POMC
37 morphine dependence 10.3 CCK OPRK1 OPRM1 TRPV1
38 nasal cavity adenocarcinoma 10.3 CCK PDYN
39 irritable bowel syndrome 10.3 CCK HTR7 TAC1 TRPV1
40 substance dependence 10.3 CNR1 OPRK1 OPRM1 POMC
41 migraine with or without aura 1 10.3 CNR1 HTR7 TAC1 TRPV1
42 opioid addiction 10.2 CCK OPRK1 OPRM1 PNOC
43 anxiety 10.2 CCK CNR1 OPRL1 OXT
44 withdrawal disorder 10.2 CNR1 HTR7 OPRM1 PDYN POMC
45 cutaneous solitary mastocytoma 10.1 PDYN POMC
46 drug dependence 10.0 CNR1 OPRK1 OPRL1 OPRM1 PDYN POMC
47 parkinson disease, late-onset 10.0 CNR1 PDYN TAC1 TRPV1
48 episodic pain syndrome, familial, 1 9.8
49 dwarfism 9.8
50 disease of mental health 9.7 CCK CNR1 HTR7 OPRM1 OXT PDYN

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 POMC TAC1 TRPV1 CCK CNR1 HTR7
2 homeostasis/metabolism MP:0005376 9.93 AP1M2 CCK CNR1 HTR7 LIPN OPRK1
3 adipose tissue MP:0005375 9.8 CNR1 OPRM1 OXT PDYN POMC TRPV1
4 integument MP:0010771 9.7 CNR1 HTR7 OPRK1 OPRL1 OPRM1 OXT
5 nervous system MP:0003631 9.32 PDYN POMC TRPV1 CCK CNR1 HTR7

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 648)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 6740-88-1 3821
2
Nalbuphine Approved Phase 4,Phase 2,Phase 3,Phase 1 20594-83-6 5311304 5360630
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
4
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 84057-95-4 175805 71273
5
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 27203-92-5 33741
6
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
7
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-27-2 5288826
8 Nefopam Approved, Investigational Phase 4,Phase 3,Phase 2 13669-70-0
9
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 437-38-7 3345
11
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 27262-47-1 92253
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
13
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 4205-90-7 2803
14
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 56030-54-7 41693
15
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
16 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 329-65-7
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
18
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
19
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
20
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
21
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
22
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
24 Cisatracurium Approved, Experimental Phase 4,Early Phase 1 96946-41-7
25
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
26
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 2078-54-8 4943
27
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 132875-61-7 60815
28
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
29
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
30
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 28523-86-6 5206
31
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 60142-96-3 3446
32
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
33
Benzoic Acid Approved, Investigational Phase 4 65-85-0 243
34
Mineral oil Approved, Vet_approved Phase 4,Phase 3 8042-47-5
35
Prilocaine Approved Phase 4,Phase 2,Phase 3 721-50-6 4906
36
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
37
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
38
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
39
Codeine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 76-57-3 5284371
40
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
41
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2 22204-53-1 156391 1302
42
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
43
Droperidol Approved, Vet_approved Phase 4,Phase 3 548-73-2 3168
44
Meperidine Approved Phase 4,Phase 3,Phase 2 57-42-1 4058
45
Ethyl chloride Approved, Experimental, Investigational Phase 4,Early Phase 1 75-00-3
46
Tetracaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 94-24-6 5411
47
Chloroprocaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 133-16-4 8612
48
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 59-46-1 4914
49
Terbutaline Approved Phase 4 23031-25-6 5403
50
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263

Interventional clinical trials:

(show top 50) (show all 3390)

# Name Status NCT ID Phase Drugs
1 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
2 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
3 Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
4 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
5 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
6 Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
7 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
8 Analgesia After Total Knee Arthroplasty Unknown status NCT00869037 Phase 4 Periarticular Injection;CFNB + Posterior Capsular Injection
9 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
10 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
11 Postoperative Analgesia by Epidural vs IV Ketamine Concurrent With Caudal Anesthesia in Pediatric Orthopedic Surgery Unknown status NCT00532662 Phase 4 S(+)-ketamine
12 Patient Re-education vs. Background Morphine to IV-PCA in Patient With Unsatisfactory Analgesia Post Laparotomy Unknown status NCT02523846 Phase 4 morphine
13 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
14 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
15 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
16 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
17 Home Infusors for Analgesia After Foot Surgery Unknown status NCT00600899 Phase 4
18 Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT01465191 Phase 4 Morphine
19 Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy Unknown status NCT01698203 Phase 4 ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
20 the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation Unknown status NCT02635802 Phase 4 Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
21 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
22 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
23 The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
24 A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery Unknown status NCT00244283 Phase 4 Sevoflurane
25 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
26 Quadratus Lumborum Block for Postoperative Analgesia After Colostomy Closure Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
27 Fast-release Orodispersible Tramadol as Analgesia in Termination of Pregnancy by Vacuum Aspiration. Unknown status NCT02416141 Phase 4 fast release oro dispersible tramadol 50 mg
28 Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery Unknown status NCT02576223 Phase 4 Ropivacaine hydrochloride;Isotonic Saline
29 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery Unknown status NCT02672813 Phase 4
30 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
31 Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically Unknown status NCT02355093 Phase 4 ropivacaine
32 Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice Unknown status NCT01303614 Phase 4 Lidocaine-Prilocaine cream;placebo
33 Perioperative Analgesia After Knee Arthroplasty Unknown status NCT01225484 Phase 4
34 Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy Unknown status NCT01542697 Phase 4 intraperitoneal nebulisation of magnesium sulphate
35 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
36 Minimum Effective Dose (MED) & Epidural Bupivacaine Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
37 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
38 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
39 Dexamethasone and Block Duration in Upper Extremity Unknown status NCT01756573 Phase 4 Dexamthsone;Bupivacaine
40 Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Knee Arthroplasty Unknown status NCT02453321 Phase 4 Bupivacaine
41 Transversus Abdominis Plane Block (TAP) for Laparoscopic Cholecystectomy Surgery Unknown status NCT02185716 Phase 4 Levobupivacaine 0.25 %;Levobupivacaine 0.5%
42 Effect of Dexamethasone on Duration of Lower Extremity Blocks With Bupivacaine in Subjects Having ACL Repair Unknown status NCT01756560 Phase 4 dexamethsone;Bupivacaine
43 Serratus Anterior Plane Block Versus Paravertebral Block for Postmastectomy Analgesia Unknown status NCT02103946 Phase 4
44 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
45 Quadratus Lumborum Block for Percutaneous Nephrostomy Unknown status NCT02121951 Phase 4 MAC
46 Postoperative Analgesia in Laminectomy Unknown status NCT02255955 Phase 4 550 mg naproxen sodium and 30mg codeine;300 mg paracetamol and 30 mg codeine;placebo tablet
47 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
48 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
49 Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor Unknown status NCT01621230 Phase 4 epidural 0.125% bupivacaine with fentanyl 2 mcg/cc infusion;fentanyl 10 mcg/cc epidural infusion
50 Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection Unknown status NCT00822133 Phase 4 lidocaine;ketamine;non-active drug cream

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

38
Breast, Liver, Colon, Brain, Bone, Lung, Heart

Publications for Pain Agnosia

Articles related to Pain Agnosia:

# Title Authors Year
1
Pain agnosia and self-injury in the syndrome of reversible somatotropin deficiency (psychosocial dwarfism). ( 5068666 )
1972

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CNR1 HTR7 OPRK1 OPRL1 OPRM1 PSENEN
2 neuron projection GO:0043005 9.78 OPRK1 OPRL1 OPRM1 TRPV1
3 axon GO:0030424 9.73 CCK CNR1 OPRM1 TAC1
4 neuronal cell body GO:0043025 9.63 CCK OPRK1 PDYN PNOC TAC1 TRPV1
5 perikaryon GO:0043204 9.56 CCK NPFF OPRK1 OPRM1
6 terminal bouton GO:0043195 9.5 AP2M1 CCK OXT
7 clathrin adaptor complex GO:0030131 9.4 AP1M2 AP2M1
8 axon terminus GO:0043679 9.26 NPFF OPRK1 PDYN PNOC
9 dendrite GO:0030425 9.17 CCK NPFF OPRK1 OPRM1 PDYN PNOC
10 plasma membrane GO:0005886 10.23 AP2M1 CNR1 HTR7 OPRK1 OPRL1 OPRM1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.92 HTR7 NPFF OPRK1 OPRL1 OPRM1 PDYN
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 NPFF OPRL1 OXT TAC1 TRPV1
3 response to morphine GO:0043278 9.83 CNR1 NPFF OPRK1 OPRM1 TAC1
4 response to ethanol GO:0045471 9.82 CNR1 OPRK1 OPRM1
5 eating behavior GO:0042755 9.8 CCK OPRK1 OPRL1 OPRM1 OXT
6 excitatory postsynaptic potential GO:0060079 9.79 NPFF OPRM1 TRPV1
7 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.77 OPRK1 OPRL1 OPRM1
8 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.76 CNR1 HTR7 OPRM1
9 response to cocaine GO:0042220 9.76 CNR1 OPRK1 OPRM1 OXT
10 negative regulation of blood pressure GO:0045776 9.75 CNR1 OPRL1 OXT
11 sensory perception of pain GO:0019233 9.73 CNR1 OPRK1 OPRL1 OPRM1 TAC1 TRPV1
12 positive regulation of blood pressure GO:0045777 9.7 CNR1 NPFF OXT
13 estrous cycle GO:0044849 9.69 OPRK1 OPRL1 OPRM1
14 response to food GO:0032094 9.65 OPRM1 OXT
15 response to pain GO:0048265 9.65 TAC1 TRPV1
16 opioid receptor signaling pathway GO:0038003 9.65 OPRK1 OPRL1 OPRM1
17 negative regulation of cAMP biosynthetic process GO:0030818 9.64 OPRL1 OPRM1
18 positive regulation of ossification GO:0045778 9.64 OXT TAC1
19 positive regulation of renal sodium excretion GO:0035815 9.63 OXT TAC1
20 maternal behavior GO:0042711 9.63 OPRK1 OXT
21 behavior GO:0007610 9.62 OPRK1 OPRL1
22 negative regulation of heart rate GO:0010459 9.62 NPFF TAC1
23 negative regulation of appetite GO:0032099 9.61 CCK NPFF
24 acute inflammatory response to antigenic stimulus GO:0002438 9.6 NPFF OPRM1
25 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.55 OPRK1 OPRM1
26 sensory perception GO:0007600 9.55 OPRK1 OPRL1 OPRM1 PDYN PNOC
27 positive regulation of gastric acid secretion GO:0060454 9.54 OPRL1 TRPV1
28 regulation of sensory perception of pain GO:0051930 9.43 CCK NPFF OPRK1 OPRL1 OPRM1 OXT
29 neuropeptide signaling pathway GO:0007218 9.23 NPFF OPRK1 OPRL1 OPRM1 PDYN PNOC
30 signal transduction GO:0007165 10.27 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
31 G-protein coupled receptor signaling pathway GO:0007186 10.15 CCK CNR1 HTR7 NPFF OPRK1 OPRL1
32 regulation of receptor activity GO:0010469 10.03 CCK NPFF OXT PDYN PNOC POMC

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 CCK OXT POMC
2 neuropeptide binding GO:0042923 9.33 OPRK1 OPRL1 OPRM1
3 opioid receptor binding GO:0031628 9.32 PDYN PNOC
4 opioid peptide activity GO:0001515 9.26 PDYN PNOC
5 opioid receptor activity GO:0004985 9.13 OPRK1 OPRL1 OPRM1
6 neuropeptide hormone activity GO:0005184 9.1 CCK NPFF OXT PDYN PNOC POMC

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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