MCID: PNG002
MIFTS: 26

Pain Agnosia malady

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

Aliases & Descriptions for Pain Agnosia:

Name: Pain Agnosia 12 14
Analgesia 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to chronic pain requiring intraspinal analgesia and neuropathy, hereditary sensory and autonomic, type v. An important gene associated with Pain Agnosia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
id Related Disease Score Top Affiliating Genes
1 chronic pain requiring intraspinal analgesia 11.8
2 neuropathy, hereditary sensory and autonomic, type v 11.1
3 congenital insensitivity to pain with hyperhidrosis 10.8
4 congenital insensitivity to pain with severe intellectual disability 10.8
5 acute contagious conjunctivitis 10.2 CCK OPRM1 PDYN
6 testicular leydig cell tumor 10.2 OPRM1 TAC1 TRPV1
7 autoimmune progesterone dermatitis 10.2 CNR1 TRPV1
8 scleral staphyloma 10.2 CCK HTR7 TRPV1
9 cervicitis 10.2 CCK OPRK1 OPRM1
10 peripheral vertigo 10.2 OPRK1 OPRM1 PNOC
11 siberian tick typhus 10.2 CNR1 HTR7 PDYN
12 suppurative periapical periodontitis 10.2 OPRK1 OPRM1 PDYN POMC
13 deafness, autosomal recessive 20 10.2 CCK HTR7 TAC1 TRPV1
14 transmitted_by 10.2 OPRK1 OPRM1 PDYN POMC
15 astroblastoma 10.2 LIPN OXT POMC
16 tuberculous peritonitis 10.2 CCK HTR7 TAC1 TRPV1
17 sweat gland cancer 10.2 CCK OPRM1 TAC1
18 hypereosinophilic syndrome 10.1 CNR1 OPRK1 OPRM1 POMC
19 keratosis 10.1 HTR7 OXT POMC
20 cholesteatoma 10.1 CCK CNR1 POMC
21 autoimmune disease of endocrine system 10.1 CNR1 HTR7 OPRM1 PDYN POMC
22 cutaneous porphyria 10.1 CNR1 TRPV1
23 uterine ligament serous adenocarcinoma 10.0 RPL34 TAC1 TRPV1
24 hypoglycemia 10.0 CNR1 OPRK1 OPRL1 OPRM1 PDYN POMC
25 epidural abscess 10.0
26 horner's syndrome 10.0
27 neuropathy 9.8
28 personality disorder 9.8 CCK CNR1 HTR7 OPRM1 OXT PDYN
29 cerebritis 9.7
30 preeclampsia/eclampsia 5 9.7 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
31 postherpetic neuralgia 9.7
32 morphine dependence 9.7
33 aneurysm 9.7
34 back pain 9.7
35 agnosia 9.7
36 dwarfism 9.7
37 priapism 9.6
38 aortic aneurysm 9.6
39 meralgia paresthetica 9.6
40 vaginitis 9.6
41 bone fracture 9.6
42 hypospadias 9.6
43 synovitis 9.6
44 cerebral palsy 9.6
45 paralytic ileus 9.6
46 paroxysmal nocturnal hemoglobinuria 9.5
47 spondylitis 9.5
48 arachnoiditis 9.5
49 constipation 9.5
50 paresthesia 9.5

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
2 homeostasis/metabolism MP:0005376 9.93 OPRM1 OXT PDYN POMC TRPV1 AP1M2
3 adipose tissue MP:0005375 9.8 CNR1 OPRM1 OXT PDYN POMC TRPV1
4 integument MP:0010771 9.7 HTR7 OPRK1 OPRL1 OPRM1 OXT PDYN
5 nervous system MP:0003631 9.32 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1

Drugs & Therapeutics for Pain Agnosia

Search Clinical Trials , NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

Publications for Pain Agnosia

Articles related to Pain Agnosia:

id Title Authors Year
1
Pain agnosia and self-injury in the syndrome of reversible somatotropin deficiency (psychosocial dwarfism). ( 5068666 )
1972

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CNR1 HTR7 OPRK1 OPRL1 OPRM1 PSENEN
2 neuron projection GO:0043005 9.78 OPRK1 OPRL1 OPRM1 TRPV1
3 axon GO:0030424 9.71 CCK CNR1 OPRM1 TAC1
4 neuronal cell body GO:0043025 9.63 CCK OPRK1 PDYN PNOC TAC1 TRPV1
5 perikaryon GO:0043204 9.56 CCK NPFF OPRK1 OPRM1
6 terminal bouton GO:0043195 9.5 AP2M1 CCK OXT
7 clathrin adaptor complex GO:0030131 9.43 AP1M2 AP2M1
8 axon terminus GO:0043679 9.26 NPFF OPRK1 PDYN PNOC
9 dendrite GO:0030425 9.17 CCK NPFF OPRK1 OPRM1 PDYN PNOC
10 plasma membrane GO:0005886 10.23 AP2M1 CNR1 HTR7 OPRK1 OPRL1 OPRM1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 CCK CNR1 PSENEN TRPV1
2 chemical synaptic transmission GO:0007268 9.92 HTR7 NPFF OPRK1 OPRL1 OPRM1 PDYN
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 NPFF OPRL1 OXT TAC1 TRPV1
4 response to ethanol GO:0045471 9.82 CNR1 OPRK1 OPRM1
5 response to morphine GO:0043278 9.8 CNR1 NPFF OPRK1 OPRM1 TAC1
6 excitatory postsynaptic potential GO:0060079 9.78 NPFF OPRM1 TRPV1
7 eating behavior GO:0042755 9.77 CCK OPRK1 OPRL1 OPRM1 OXT
8 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.75 OPRK1 OPRL1 OPRM1
9 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.74 CNR1 HTR7 OPRM1
10 negative regulation of blood pressure GO:0045776 9.73 CNR1 OPRL1 OXT
11 response to cocaine GO:0042220 9.73 CNR1 OPRK1 OPRM1 OXT
12 sensory perception of pain GO:0019233 9.73 CNR1 OPRK1 OPRL1 OPRM1 TAC1 TRPV1
13 positive regulation of blood pressure GO:0045777 9.69 CNR1 NPFF OXT
14 estrous cycle GO:0044849 9.67 OPRK1 OPRL1 OPRM1
15 response to food GO:0032094 9.65 OPRM1 OXT
16 response to pain GO:0048265 9.64 TAC1 TRPV1
17 negative regulation of cAMP biosynthetic process GO:0030818 9.63 OPRL1 OPRM1
18 positive regulation of ossification GO:0045778 9.63 OXT TAC1
19 opioid receptor signaling pathway GO:0038003 9.63 OPRK1 OPRL1 OPRM1
20 maternal behavior GO:0042711 9.62 OPRK1 OXT
21 positive regulation of renal sodium excretion GO:0035815 9.62 OXT TAC1
22 behavior GO:0007610 9.61 OPRK1 OPRL1
23 negative regulation of heart rate GO:0010459 9.6 NPFF TAC1
24 negative regulation of appetite GO:0032099 9.59 CCK NPFF
25 acute inflammatory response to antigenic stimulus GO:0002438 9.58 NPFF OPRM1
26 sensory perception GO:0007600 9.55 OPRK1 OPRL1 OPRM1 PDYN PNOC
27 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.54 OPRK1 OPRM1
28 positive regulation of gastric acid secretion GO:0060454 9.52 OPRL1 TRPV1
29 regulation of sensory perception of pain GO:0051930 9.43 CCK NPFF OPRK1 OPRL1 OPRM1 OXT
30 neuropeptide signaling pathway GO:0007218 9.23 NPFF OPRK1 OPRL1 OPRM1 PDYN PNOC
31 signal transduction GO:0007165 10.25 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 CCK OXT POMC
2 neuropeptide binding GO:0042923 9.33 OPRK1 OPRL1 OPRM1
3 opioid receptor binding GO:0031628 9.32 PDYN PNOC
4 opioid peptide activity GO:0001515 9.26 PDYN PNOC
5 opioid receptor activity GO:0004985 9.13 OPRK1 OPRL1 OPRM1
6 neuropeptide hormone activity GO:0005184 9.02 CCK NPFF OXT PDYN PNOC

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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