PAIN
MCID: PND001
MIFTS: 49

Pain Disorder (PAIN) malady

Summaries for Pain Disorder

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards: Pain Disorder, also known as PAIN, is related to complex regional pain syndrome and neuropathy. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Interaction between L1 and Ankyrins and Sodium channels and transporters: inward current. The compounds Lacosamide and aft-ii have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and prostate, and related mouse phenotypes are integument and behavior/neurological.

Disease Ontology:8 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:63 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 25ICD10
See all sources

Related Diseases for Pain Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pain Disorder family:

Chronic Pain

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1765)
idRelated DiseaseScoreTop Affiliating Genes
1complex regional pain syndrome31.5TAC1
2neuropathy31.2SCN8A, SCN9A, NGF, TAC1
3migraine30.6PNOC, TAC1
4constipation30.4TAC1
5ischemia30.1GAL, PNOC, ADRB2
6erythromelalgia30.1SCN3A, SCN8A, SCN9A
7diabetes mellitus30.1TAC1, NGF, CABIN1
8fibromyalgia30.0PNOC, TAC1
9pain agnosia29.9PNOC, TAC1
10dermatitis29.8TAC1
11ganglioneuroma29.7NGF, GAL
12cystitis29.6TAC1, NGF
13long qt syndrome29.6SCN3A, SCN4B, SCN8A
14respiratory failure29.5ADRB2, TAC1
15type 2 diabetes mellitus29.5ADRB2, NGF, GAL
16parkinson's disease29.5ADRB2, TAC1, NGF, GAL
17atopic dermatitis29.3NGF, CABIN1
18brugada syndrome29.3SCN8A, SCN4B
19cholera29.3ADRB2, TAC1, NGF, GAL
20malignant glioma29.3GAL, NGF, TAC1, PNOC, ADRB2
21patellofemoral pain syndrome10.8
22myofascial pain syndrome10.7
23prostatitis10.7
24diabetic neuropathy10.7
25osteoarthritis10.6
26cervicitis10.6
27somatoform disorder10.6
28anhidrosis10.6
29peripheral neuropathy10.5
30arthritis10.5
31reflex sympathetic dystrophy10.5
32radiculopathy10.5
33pancreatitis10.5
34polyneuropathy10.5
35endometriosis10.4
36trigeminal neuralgia10.4
37neuroma10.4
38ophthalmoplegia10.4
39causalgia10.4
40herpes zoster10.4
41fasciitis10.4
42spinal stenosis10.4
43sickle cell disease10.4
44plantar fasciitis10.4
45rheumatoid arthritis10.4
46paroxysmal extreme pain disorder10.4
47chronic pain10.4
48diabetic polyneuropathy10.4
49bursitis10.4
50chronic interstitial cystitis10.3

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Clinical Features for Pain Disorder

About this section

Drugs & Therapeutics for Pain Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pain Disorder

Drug clinical trials:

Search ClinicalTrials for Pain Disorder

Search NIH Clinical Center for Pain Disorder

Search CenterWatch for Pain Disorder

Genetic Tests for Pain Disorder

About this section

Anatomical Context for Pain Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pain Disorder:

32
Bone, Spinal cord, Prostate, Testes, Brain, Breast, Pituitary

Animal Models for Pain Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pain Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0PNOC, TAC1, NGF, GAL, SCN9A
2MP:00053866.6ADRB2, SCN3A, SCN8A, SCN9A, GAL, NGF

Publications for Pain Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Pain Disorder:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Influence of vestibular rehabilitation on neck pain and cervical range of motion among patients with whiplash-associated disorder: a randomized controlled trial. (23974698)
2013
2
Efficacy of extended-release quetiapine fumarate monotherapy in elderly patients with major depressive disorder: secondary analyses in subgroups of patients according to baseline anxiety, sleep disturbance, and pain levels. (24162081)
2013
3
Alexithymia partly predicts pain, poor health and social difficulties in patients with temporomandibular disorders. (23869944)
2013
4
The clinical course over the first year of Whiplash Associated Disorders (WAD): pain-related disability predicts outcome in a mildly affected sample. (24359208)
2013
5
Pain in primary care patients with bipolar disorder. (24360835)
2013
6
Dysfunctional pain inhibition in patients with chronic whiplash-associated disorders: an experimental study. (22983264)
2013
7
How well are you recovering? The association between a simple question about recovery and patient reports of pain intensity and pain disability in whiplash-associated disorders. (21936737)
2012
8
Widespread pain hypersensitivity and facilitated temporal summation of deep tissue pain in whiplash associated disorder: an explorative study of women. (22729792)
2012
9
Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample. (21596207)
2011
10
Efficacy of 2 interventions for panic disorder in patients presenting to the ED with chest pain. (20870368)
2011
11
Post-traumatic stress disorder moderates the relation between documented childhood victimization and pain 30 years later. (21050659)
2011
12
Re: Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample. (22078588)
2011
13
Dysfunctional pain modulation in somatoform pain disorder patients. (20924589)
2011
14
Frequent jaw-face pain in chronic Whiplash-Associated Disorders. (22135943)
2011
15
Cognitive determinants of pain and disability in patients with chronic whiplash-associated disorder: a cross-sectional observational study. (20420962)
2010
16
Altered scapular orientation during arm elevation in patients with insidious onset neck pain and whiplash-associated disorder. (20972341)
2010
17
A study of the test-retest reliability of the self-perceived general recovery and self-perceived change in neck pain questions in patients with recent whiplash-associated disorders. (20130932)
2010
18
Cognitive determinants of pain and disability in patients with chronic whiplash-associated disorder: a cross-sectional observational study. (21056172)
2010
19
Memory performance related to organic and psychosocial illness attributions in somatoform pain disorder patients. (19686875)
2009
20
Nondermatomal somatosensory deficits in patients with chronic pain disorder: clinical findings and hypometabolic pattern in FDG-PET. (19500908)
2009
21
Factors associated with pain interference in an epidemiologic sample of adults with bipolar I disorder. (19203799)
2009
22
Cervical helical axis characteristics and its center of rotation during active head and upper arm movements-comparisons of whiplash-associated disorders, non-specific neck pain and asymptomatic individuals. (18707689)
2008
23
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. (17723312)
2008
24
The future of the DSM pain disorder category. (18621944)
2008
25
The burden and determinants of neck pain in whiplash-associated disorders after traffic collisions: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. (18204401)
2008
26
From genes to pain: Na v 1.7 and human pain disorders. (17950472)
2007
27
Perception for ischemic pain shows similarities in adjustment disorder and major depression. (17239636)
2007
28
A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder. (16838829)
2006
29
Chronic pain disorder manifesting as dental pain: case report. (16512099)
2006
30
What's in a name--familial rectal pain syndrome becomes paroxysmal extreme pain disorder. (17043302)
2006
31
Randomized double-blind comparison of serotonergic (Citalopram) versus noradrenergic (Reboxetine) reuptake inhibitors in outpatients with somatoform, DSM-IV-TR pain disorder. (15629872)
2005
32
Pain disorder, hysteria or somatization? (15197414)
2004
33
Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain. (15023866)
2004
34
Somatoform pain disorder: a valid diagnosis? (12807381)
2003
35
Chronic pain disorder associated with psychogenic versus somatic factors: a comparative study. (12745793)
2003
36
Incomplete response to endoscopic sphincterotomy in patients with sphincter of Oddi dysfunction: evidence for a chronic pain disorder. (12907327)
2003
37
Somatoform pain disorder in the general population. (12601226)
2003
38
Memory bias in patients with hypochondriasis and somatoform pain disorder. (11801264)
2002
39
Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain. (11698040)
2001
40
Hip pain in the young adult: diagnosis and treatment of disorders of the acetabular labrum and acetabular dysplasia. (11411872)
2001
41
The DSM-IV nosology of chronic pain: a comparison of pain disorder and multiple somatization syndrome. (10833555)
2000
42
Where have two DSM revisions taken us for the diagnosis of pain disorder in chronic pain patients? (8540581)
1996
43
Difficulties in the differential diagnosis of vaginismus, dyspareunia and mixed sexual pain disorder. (8748995)
1995
44
Alexithymia in somatoform disorder patients with chronic pain. (7990060)
1994
45
Pain as a manifestation of seizure disorder. (8500249)
1993
46
Is acupuncture an alternative in idiopathic pain disorder? (1441862)
1992
47
Burning mouth syndrome: pain disorder remains difficult to treat. (3470697)
1987
48
Chronic pain in a patient with a somatization disorder. (6691582)
1984
49
Interrelationships of conversion, psychogenic pain, and dissociative disorder symptoms. (6630698)
1983
50
idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder. (7086398)
1982

Genetic Variations for Pain Disorder

About this section

Expression for genes affiliated with Pain Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

About this section
Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Pain Disorder

About this section
Sources:
11DrugBank, 28IUPHAR, 44Novoseek, 49PharmGKB, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Pain Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Lacosamide1110.2SCN9A, SCN3A
2aft-ii2810.1SCN8A, SCN3A
3bc-iii2810.1SCN8A, SCN3A
4atx-ii2810.1SCN3A, SCN8A
5clenbuterol44 1110.9NGF, ADRB2
6saxitoxin289.9SCN9A, SCN3A, SCN8A
7batrachotoxin289.9SCN3A, SCN8A, SCN9A
8gnrh449.9ADRB2, GAL
9octadecaneuropeptide449.8PNOC, GAL
10zonisamide44 1110.7SCN9A, SCN4B, SCN3A
11helospectin449.7GAL, TAC1
12naloxone44 49 28 1112.6ADRB2, GAL, PNOC
13phenoxybenzamine44 1110.5TAC1, ADRB2
14fenoterol44 28 1111.5TAC1, ADRB2
15phrixotoxin 3599.4SCN3A, SCN4B, SCN8A, SCN9A
16qx 314 chloride599.4SCN4B, SCN9A, SCN8A, SCN3A
17tetrodotoxin citrate599.4SCN3A, SCN4B, SCN8A, SCN9A
18veratridine44 59 2811.4SCN4B, SCN8A, SCN9A, SCN3A
19ltd4449.3TAC1, GAL
20guanethidine44 1110.2TAC1, PNOC
21theophylline44 28 11 2412.2NGF, TAC1, ADRB2
22propranolol44 28 49 11 2413.2TAC1, ADRB2, NGF
23cocaine44 1110.2PNOC, GAL, NGF, ADRB2
24levodopa44 1110.2NGF, TAC1, GAL
25amphetamine44 1110.1PNOC, GAL, TAC1
26baclofen44 1110.0PNOC, TAC1
27carbachol44 28 1111.0NGF, TAC1, GAL, ADRB2
28epinephrine44 11 2410.9ADRB2, GAL, TAC1, NGF
29opiate448.8PNOC, ADRB2, GAL, TAC1
30phosphoinositide448.8TAC1, NGF, ADRB2, GAL
315-hydroxytryptamine448.8TAC1, GAL, PNOC, ADRB2
32gaba448.8PNOC, GAL, ADRB2, TAC1
33capsaicin44 289.7TAC1, PNOC, NGF, GAL
34atropine44 28 1110.7TAC1, PNOC, GAL, NGF
35pge2448.5GAL, TAC1, PNOC, ADRB2
36potassium44 11 2410.4TAC1, SCN8A, GAL, ADRB2, PNOC
37morphine44 49 28 1111.4ADRB2, NGF, GAL, PNOC, TAC1
38norepinephrine44 11 2410.4GAL, PNOC, ADRB2, TAC1, NGF
39histamine44 28 2410.4ADRB2, GAL, NGF, TAC1, PNOC
40acetylcholine44 49 28 11 2412.4PNOC, GAL, TAC1, ADRB2, NGF
41forskolin44 49 1110.4TAC1, ADRB2, GAL, NGF, PNOC
42dopamine44 28 11 2411.3NGF, GAL, ADRB2, PNOC, TAC1
43adenylate448.3GAL, ADRB2, TAC1, NGF, PNOC
44nitric oxide44 11 2410.3CABIN1, GAL, PNOC, TAC1, ADRB2
45cyclic amp44 249.3ADRB2, GAL, NGF, PNOC, TAC1
46testosterone44 59 11 2411.3ADRB2, GAL, NGF, TAC1
47tetrodotoxin44 59 2810.2SCN4B, SCN8A, SCN9A, GAL, SCN3A, TAC1
48glutamate448.2GAL, NGF, TAC1, PNOC, ADRB2
49estrogen448.0ADRB2, PNOC, GPER1, TAC1, GAL
50sodium44 248.6GAL, TAC1, PNOC, SCN9A, SCN3A, SCN4B

GO Terms for genes affiliated with Pain Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015188.9SCN9A, SCN8A, SCN4B, SCN3A

Biological processes related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of action potential in neuronGO:0192289.6GPER1, SCN9A
2peripheral nervous system developmentGO:0074229.3NGF, SCN8A
3positive regulation of apoptotic processGO:0430659.2GPER1, NGF, GAL
4sodium ion transportGO:0068149.0SCN9A, SCN8A, SCN4B, SCN3A
5neuropeptide signaling pathwayGO:0072188.7GAL, TAC1, PNOC
6inflammatory responseGO:0069548.7TAC1, NGF, GAL, SCN9A

Molecular functions related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6PNOC, GAL
2voltage-gated sodium channel activityGO:0052488.6SCN9A, SCN8A, SCN4B, SCN3A

Products for genes affiliated with Pain Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pain Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet