PAIN
MCID: PND001
MIFTS: 48

Pain Disorder (PAIN) malady

Mental diseases category
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Summaries for Pain Disorder

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards: Pain Disorder, also known as PAIN, is related to neuropathy and paroxysmal extreme pain disorder. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Selected targets of CREB1. The compounds atx-ii and aft-ii have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and integument.

Disease Ontology:8 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:65 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 34MedlinePlus, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

pain disorder 8 10 45 62
pain 34


External Ids:

Disease Ontology8 DOID:0060164
ICD1025 R52, R52.9

Related Diseases for Pain Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pain Disorder family:

Chronic Pain

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1883)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy31.2NGF, SCN8A, SCN9A, TAC1
2paroxysmal extreme pain disorder31.0SCN9A
3arthritis30.8GAL, ADRB2, TAC1
4migraine30.8PNOC, TAC1
5hypertension30.3TAC1, ADRB2, CABIN1
6ischemia30.3PNOC, GAL, ADRB2
7fibromyalgia30.2TAC1, PNOC
8erythromelalgia30.2SCN3A, SCN9A, SCN8A
9diabetes mellitus30.1TAC1, CABIN1, NGF
10pain agnosia30.0TAC1, PNOC
11pheochromocytoma29.9ADRB2, GAL, NGF
12ganglioneuroma29.8GAL, NGF
13cystitis29.8TAC1, NGF
14long qt syndrome29.7SCN8A, SCN4B, SCN3A
15schizophrenia29.7TAC1, PNOC, NGF
16respiratory failure29.7TAC1, ADRB2
17parkinson's disease29.6NGF, ADRB2, TAC1, GAL
18rhinitis29.5TAC1
19prolactinoma29.5GAL, NGF
20brugada syndrome29.4SCN8A, SCN4B
21neuroendocrine tumor29.4GAL, TAC1
22atopic dermatitis29.4CABIN1, NGF
23type 2 diabetes mellitus29.4NGF, ADRB2, GAL
24carcinoid syndrome29.4NGF, GAL, TAC1
25psoriasis29.4ADRB2, TAC1, NGF
26hypersensitivity reaction type ii disease29.4TAC1, ADRB2, GAL
27cholera29.4GAL, TAC1, ADRB2, NGF
28malignant glioma29.3PNOC, TAC1, NGF, ADRB2, GAL
29complex regional pain syndrome11.0
30patellofemoral pain syndrome10.8
31prostatitis10.8
32myofascial pain syndrome10.7
33diabetic neuropathy10.7
34whiplash10.7
35osteoarthritis10.7
36congenital insensitivity to pain with anhidrosis10.6
37cervicitis10.6
38complex regional pain syndrome type 110.6
39anhidrosis10.6
40central post-stroke pain10.6
41postherpetic neuralgia10.6
42reflex sympathetic dystrophy10.6
43peripheral neuropathy10.5
44headache10.5
45radiculopathy10.5
46pancreatitis10.5
47polyneuropathy10.5
48endometriosis10.5
49neuroma10.5
50ophthalmoplegia10.5

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Symptoms for Pain Disorder

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Drugs & Therapeutics for Pain Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pain Disorder

Search NIH Clinical Center for Pain Disorder

Genetic Tests for Pain Disorder

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Anatomical Context for Pain Disorder

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Animal Models for Pain Disorder or affiliated genes

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Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Pain Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4ADRB2, SCN3A, NGF, GPER1
2MP:00107718.2PNOC, NGF, SCN9A, GAL, TAC1
3MP:00053787.5GPER1, NGF, SCN8A, SCN3A, ADRB2, GAL
4MP:00053857.5GPER1, NGF, SCN8A, ADRB2, TAC1
5MP:00053867.1TAC1, PNOC, NGF, SCN8A, SCN9A, SCN3A

Publications for Pain Disorder

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Sources:
52PubMed
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Articles related to Pain Disorder:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. (23689753)
2014
2
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. (24428222)
2014
3
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. (23893323)
2014
4
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. (24179828)
2013
5
Paroxysmal extreme pain disorder. (23599527)
2013
6
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. (23738195)
2012
7
The causes and prevalence of vestibulodynia: a vulvar pain disorder. (21542444)
2011
8
Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. (21079636)
2011
9
Case reports: anesthesia for a patient with paroxysmal extreme pain disorder. (20435947)
2010
10
Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study. (20727111)
2010
11
Post-traumatic external nasal pain syndrome (a trigeminal based pain disorder). (19619239)
2009
12
The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. (19349078)
2009
13
Memory performance related to organic and psychosocial illness attributions in somatoform pain disorder patients. (19686875)
2009
14
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. (19733606)
2009
15
Nondermatomal somatosensory deficits in patients with chronic pain disorder: clinical findings and hypometabolic pattern in FDG-PET. (19500908)
2009
16
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. (17723312)
2008
17
Redefining (somatoform) pain disorder in ICD-10: a compromise of different interest groups in Germany. (18332667)
2008
18
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. (18803825)
2008
19
Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. (18599537)
2008
20
Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study. (17428684)
2007
21
From genes to pain: Na v 1.7 and human pain disorders. (17950472)
2007
22
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. (17145499)
2006
23
Re: Goldby LJ, Moore AP, Doust J, et al. A randomized control trial investigating the efficiency of musculoskeletal physiotherapy on chronic back pain disorder. Spine 2006;31:1083-93. (16985474)
2006
24
A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder. (16838829)
2006
25
Chronic pain disorder manifesting as dental pain: case report. (16512099)
2006
26
What does the WHOQOL-Bref measure? Measurement overlap between quality of life and depressive symptomatology in chronic somatoform pain disorder. (16341612)
2006
27
DSM-IV pain disorder in the general population. An exploration of the structure and threshold of medically unexplained pain symptoms. (16328107)
2006
28
Dyspareunia: a pain disorder or sexual dysfunction? (16092026)
2005
29
Vulvar disease: a pelvic floor pain disorder? (15970821)
2005
30
Somatoform pain disorder: a valid diagnosis? (12807381)
2003
31
A preliminary open-label study of moclobemide treatment of pain disorder. (14608245)
2003
32
Sleep disturbances in somatoform pain disorder. (14707439)
2003
33
Chronic pain disorder associated with psychogenic versus somatic factors: a comparative study. (12745793)
2003
34
Does nociceptin play a role in pain disorders in man? (12217418)
2002
35
Hypnorelaxation as treatment for myofascial pain disorder: a comparative study. (12029281)
2002
36
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
37
Memory bias in patients with hypochondriasis and somatoform pain disorder. (11801264)
2002
38
Interactions of a history of migration with the course of pain disorder. (11399284)
2001
39
Vaginismus is better not included in sexual pain disorder. (11247223)
2001
40
Treatment of functional impairment in severe somatoform pain disorder: a case example. (11553697)
2001
41
Chronic pain disorder following physical injury. (10849455)
2000
42
The DSM-IV nosology of chronic pain: a comparison of pain disorder and multiple somatization syndrome. (10833555)
2000
43
Clinical utility of DSM-IV pain disorder. (10509617)
1999
44
Onchologic stress: its causality in myofascial pain disorder or in temporomandibular disorder. (9543900)
1998
45
Where have two DSM revisions taken us for the diagnosis of pain disorder in chronic pain patients? (8540581)
1996
46
Difficulties in the differential diagnosis of vaginismus, dyspareunia and mixed sexual pain disorder. (8748995)
1995
47
Psychiatric consequences of road traffic accidents. Consider somatoform pain disorder. (8281072)
1993
48
Personality traits in patients with idiopathic pain disorder. (3434321)
1987
49
Chronic idiopathic pain disorder. (3723450)
1986
50
idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder. (7086398)
1982

Variations for Pain Disorder

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Expression for genes affiliated with Pain Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

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Sources:
50PathCards, 51PharmGKB, 12EMD Millipore, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG
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Pathways related to Pain Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ADRB2, SCN4B
29.5GAL, PNOC
3
Show member pathways
9.4SCN8A, SCN9A, SCN3A
4
Show member pathways
9.4SCN8A, SCN3A, SCN9A
59.4SCN9A, SCN3A, SCN8A
69.1SCN4B, NGF, TAC1
7
Show member pathways
9.1SCN8A, SCN3A, SCN9A, SCN4B
8
Show member pathways
8.7SCN3A, SCN9A, SCN4B, ADRB2, SCN8A
9
Show member pathways
8.5TAC1, SCN3A, SCN4B, SCN9A, SCN8A
10
Show member pathways
7.8ADRB2, PNOC, GAL, GPER1, TAC1
11
Show member pathways
7.3TAC1, PNOC, GAL, ADRB2, NGF, GPER1

Compounds for genes affiliated with Pain Disorder

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Pain Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1atx-ii2910.0SCN8A, SCN3A
2aft-ii2910.0SCN3A, SCN8A
3bc-iii299.9SCN8A, SCN3A
4helospectin459.9TAC1, GAL
5zonisamide45 51 1111.9SCN3A, SCN9A, SCN4B
6clenbuterol45 1110.8NGF, ADRB2
7saxitoxin299.8SCN3A, SCN8A, SCN9A
8batrachotoxin299.8SCN9A, SCN8A, SCN3A
9octadecaneuropeptide459.8GAL, PNOC
10phenoxybenzamine45 1110.8TAC1, ADRB2
11fenoterol45 29 1111.7TAC1, ADRB2
12naloxone45 29 51 1112.6PNOC, GAL, ADRB2
13phrixotoxin 3619.5SCN9A, SCN8A, SCN4B, SCN3A
14tetrodotoxin citrate619.5SCN3A, SCN4B, SCN9A, SCN8A
15guanethidine45 1110.5PNOC, TAC1
16qx 314 chloride619.5SCN3A, SCN4B, SCN9A, SCN8A
17veratridine45 61 2911.5SCN3A, SCN4B, SCN9A, SCN8A
18theophylline45 29 24 1112.4TAC1, ADRB2, NGF
19propranolol45 29 51 24 1113.4TAC1, NGF, ADRB2
20baclofen45 1110.4PNOC, TAC1
21levodopa45 1110.4TAC1, GAL, NGF
22amphetamine45 51 1111.4PNOC, GAL, TAC1
23ltd4459.3GAL, TAC1
24carbachol45 29 1111.2TAC1, ADRB2, NGF, GAL
25epinephrine45 24 1111.1GAL, NGF, TAC1, ADRB2
26opiate459.1PNOC, ADRB2, GAL, TAC1
27cocaine45 1110.1GAL, ADRB2, NGF, PNOC
285-hydroxytryptamine459.1TAC1, GAL, ADRB2, PNOC
29phosphoinositide459.0TAC1, NGF, ADRB2, GAL
30gaba459.0PNOC, TAC1, GAL, ADRB2
31capsaicin45 299.9TAC1, PNOC, GAL, NGF
32atropine45 29 1110.9NGF, GAL, TAC1, PNOC
33pge2458.9TAC1, PNOC, GAL, ADRB2
34tetrodotoxin45 61 2910.7TAC1, GAL, SCN3A, SCN9A, SCN4B, SCN8A
35testosterone45 61 24 1111.7GAL, NGF, ADRB2, TAC1
36potassium45 24 1110.6PNOC, TAC1, GAL, ADRB2, SCN8A
37nitric oxide45 24 1110.6PNOC, CABIN1, GAL, ADRB2, TAC1
38morphine45 51 29 1111.6NGF, GAL, TAC1, PNOC, ADRB2
39norepinephrine45 24 1110.6PNOC, NGF, ADRB2, GAL, TAC1
40histamine45 29 2410.6TAC1, GAL, ADRB2, NGF, PNOC
41acetylcholine45 51 29 24 1112.6PNOC, TAC1, GAL, ADRB2, NGF
42forskolin45 51 1110.6TAC1, GAL, ADRB2, NGF, PNOC
43dopamine45 29 24 1111.5GAL, NGF, TAC1, ADRB2, PNOC
44adenylate458.5TAC1, GAL, ADRB2, NGF, PNOC
45cyclic amp45 249.5PNOC, TAC1, GAL, ADRB2, NGF
46glutamate458.5TAC1, GAL, ADRB2, NGF, PNOC
47steroid458.1GPER1, CABIN1, TAC1, PNOC
48estrogen458.1PNOC, TAC1, GAL, ADRB2, GPER1
49sodium45 249.0SCN4B, TAC1, GAL, SCN9A, SCN8A, SCN3A
50calcium45 51 24 1110.3CABIN1, GPER1, GAL, PNOC, TAC1, NGF

GO Terms for genes affiliated with Pain Disorder

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16Gene Ontology
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Cellular components related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.1SCN3A, SCN4B, SCN9A, SCN8A

Biological processes related to Pain Disorder according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to toxic substanceGO:0096369.7SCN9A, SCN8A
2peripheral nervous system developmentGO:0074229.6SCN8A, NGF
3neuronal action potentialGO:0192289.5SCN9A, GPER1
4sensory perception of painGO:0192339.3TAC1, NGF
5sodium ion transportGO:0068149.3SCN3A, SCN4B, SCN9A, SCN8A
6sodium ion transmembrane transportGO:0357259.3SCN8A, SCN9A, SCN4B, SCN3A
7neuropeptide signaling pathwayGO:0072189.2PNOC, GAL, TAC1
8positive regulation of MAPK cascadeGO:0434109.0ADRB2, GPER1
9positive regulation of apoptotic processGO:0430658.8GPER1, NGF, GAL
10inflammatory responseGO:0069548.2TAC1, GAL, SCN9A, NGF, GPER1

Molecular functions related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.5GAL, PNOC
2voltage-gated sodium channel activityGO:0052488.8SCN3A, SCN4B, SCN9A, SCN8A

Products for genes affiliated with Pain Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pain Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet