MCID: PND001
MIFTS: 46

Pain Disorder malady

Rare diseases category

Summaries for Pain Disorder

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MedlinePlus:32 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards based summary: Pain Disorder, also known as paine syndrome, is related to paroxysmal extreme pain disorder and fibromyalgia, and has symptoms including microcephaly, spastic diplegia and x-linked inheritance. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Selected targets of CREB1. The compounds atx-ii and aft-ii have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and integument.

Disease Ontology:9 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:63 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

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Pain Disorder, Aliases & Descriptions:

Name: Pain Disorder 9 11 43 60
Paine Syndrome 41 60
 
Microcephaly with Spastic Diplegia 41
Pain 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:0060164
ICD1025 R52, R52.9

Related Diseases for Pain Disorder

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Diseases in the Chronic Pain family:

pain disorder

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1938)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal extreme pain disorder31.6SCN9A
2fibromyalgia30.6TAC1, PNOC
3pain agnosia30.3TAC1, PNOC
4rhinitis30.2TAC1
5migraine30.2PNOC, TAC1
6erythromelalgia30.1SCN3A, SCN9A, SCN8A
7ganglioneuroma30.1GAL, NGF
8pheochromocytoma30.0ADRB2, GAL, NGF
9cystitis30.0TAC1, NGF
10arthritis29.9GAL, ADRB2, TAC1
11respiratory failure29.9TAC1, ADRB2
12alcohol dependence29.9PNOC, GAL, NGF
13neuropathy29.8NGF, SCN8A, SCN9A, TAC1
14ischemia29.8PNOC, GAL, ADRB2
15neuroendocrine tumor29.8GAL, TAC1
16long qt syndrome29.7SCN8A, SCN4B, SCN3A
17prolactinoma29.7GAL, NGF
18schizophrenia29.6TAC1, PNOC, NGF
19brugada syndrome29.6SCN8A, SCN4B
20cholera29.6GAL, TAC1, ADRB2, NGF
21atopic dermatitis29.5CABIN1, NGF
22carcinoid syndrome29.4NGF, GAL, TAC1
23psoriasis29.3ADRB2, TAC1, NGF
24hypersensitivity reaction type ii disease29.3TAC1, ADRB2, GAL
25malignant glioma29.0PNOC, TAC1, NGF, ADRB2, GAL
26complex regional pain syndrome11.2
27patellofemoral pain syndrome11.1
28myofascial pain syndrome10.9
29prostatitis10.9
30complex regional pain syndrome type 110.8
31diabetic neuropathy10.7
32osteoarthritis10.7
33reflex sympathetic dystrophy10.7
34anhidrosis10.6
35radiculopathy10.6
36pancreatitis10.5
37neuroma10.5
38ophthalmoplegia10.5
39herpes zoster10.5
40sickle cell disease10.5
41causalgia10.5
42spinal stenosis10.5
43bone cancer10.5
44diabetic polyneuropathy10.4
45cervicitis10.4
46dystonia10.4
47chronic pain10.4
48spinal cord injury10.4
49insensitivity to pain, congenital, with anhidrosis10.4
50spasticity10.4

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Symptoms for Pain Disorder

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HPO human phenotypes related to Pain Disorder:

id Description Frequency HPO Source Accession
1 microcephaly HP:0000252
2 spastic diplegia HP:0001264
3 x-linked inheritance HP:0001417
4 generalized myoclonic seizures HP:0002123
5 olivopontocerebellar hypoplasia HP:0006955

Drugs & Therapeutics for Pain Disorder

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Drug clinical trials:

Search ClinicalTrials for Pain Disorder

Search NIH Clinical Center for Pain Disorder

Genetic Tests for Pain Disorder

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Anatomical Context for Pain Disorder

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Animal Models for Pain Disorder or affiliated genes

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MGI Mouse Phenotypes related to Pain Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4ADRB2, SCN3A, NGF, GPER1
2MP:00107718.2PNOC, NGF, SCN9A, GAL, TAC1
3MP:00053787.5GPER1, NGF, SCN8A, SCN3A, ADRB2, GAL
4MP:00053857.5GPER1, NGF, SCN8A, ADRB2, TAC1
5MP:00053867.1TAC1, PNOC, NGF, SCN8A, SCN9A, SCN3A

Publications for Pain Disorder

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Articles related to Pain Disorder:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Prevalence of restless legs syndrome in somatoform pain disorder and its effect on quality of life. (25883472)
2015
2
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. (23689753)
2014
3
Restless legs syndrome and pain disorders: what's in common? (25249423)
2014
4
Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. (24817410)
2014
5
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. (24428222)
2014
6
Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: a preliminary resting-state fMRI study. (24439113)
2014
7
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. (23893323)
2014
8
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. (24179828)
2013
9
Predicting return to work following treatment of chronic pain disorder. (23503298)
2013
10
Paroxysmal extreme pain disorder. (23599527)
2013
11
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. (23738195)
2012
12
The causes and prevalence of vestibulodynia: a vulvar pain disorder. (21542444)
2011
13
Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. (21079636)
2011
14
Case reports: anesthesia for a patient with paroxysmal extreme pain disorder. (20435947)
2010
15
Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study. (20727111)
2010
16
Post-traumatic external nasal pain syndrome (a trigeminal based pain disorder). (19619239)
2009
17
The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. (19349078)
2009
18
Memory performance related to organic and psychosocial illness attributions in somatoform pain disorder patients. (19686875)
2009
19
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. (19733606)
2009
20
Nondermatomal somatosensory deficits in patients with chronic pain disorder: clinical findings and hypometabolic pattern in FDG-PET. (19500908)
2009
21
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. (17723312)
2008
22
Redefining (somatoform) pain disorder in ICD-10: a compromise of different interest groups in Germany. (18332667)
2008
23
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. (18803825)
2008
24
Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. (18599537)
2008
25
Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study. (17428684)
2007
26
From genes to pain: Na v 1.7 and human pain disorders. (17950472)
2007
27
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. (17145499)
2006
28
Re: Goldby LJ, Moore AP, Doust J, et al. A randomized control trial investigating the efficiency of musculoskeletal physiotherapy on chronic back pain disorder. Spine 2006;31:1083-93. (16985474)
2006
29
A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder. (16838829)
2006
30
Chronic pain disorder manifesting as dental pain: case report. (16512099)
2006
31
What does the WHOQOL-Bref measure? Measurement overlap between quality of life and depressive symptomatology in chronic somatoform pain disorder. (16341612)
2006
32
Dyspareunia: a pain disorder or sexual dysfunction? (16092026)
2005
33
Vulvar disease: a pelvic floor pain disorder? (15970821)
2005
34
Somatoform pain disorder: a valid diagnosis? (12807381)
2003
35
A preliminary open-label study of moclobemide treatment of pain disorder. (14608245)
2003
36
Sleep disturbances in somatoform pain disorder. (14707439)
2003
37
Chronic pain disorder associated with psychogenic versus somatic factors: a comparative study. (12745793)
2003
38
Does nociceptin play a role in pain disorders in man? (12217418)
2002
39
Hypnorelaxation as treatment for myofascial pain disorder: a comparative study. (12029281)
2002
40
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
41
Interactions of a history of migration with the course of pain disorder. (11399284)
2001
42
Vaginismus is better not included in sexual pain disorder. (11247223)
2001
43
Treatment of functional impairment in severe somatoform pain disorder: a case example. (11553697)
2001
44
Chronic pain disorder following physical injury. (10849455)
2000
45
Onchologic stress: its causality in myofascial pain disorder or in temporomandibular disorder. (9543900)
1998
46
Where have two DSM revisions taken us for the diagnosis of pain disorder in chronic pain patients? (8540581)
1996
47
Difficulties in the differential diagnosis of vaginismus, dyspareunia and mixed sexual pain disorder. (8748995)
1995
48
Psychiatric consequences of road traffic accidents. Consider somatoform pain disorder. (8281072)
1993
49
Chronic idiopathic pain disorder. (3723450)
1986
50
idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder. (7086398)
1982

Variations for Pain Disorder

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Expression for genes affiliated with Pain Disorder

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Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

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Pathways related to Pain Disorder according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SCN4B, ADRB2
2
Show member pathways
9.4SCN3A, SCN9A, SCN8A
39.4SCN3A, SCN9A, SCN8A
49.1TAC1, SCN4B, NGF
5
Show member pathways
9.1SCN3A, SCN4B, SCN9A, SCN8A
6
Show member pathways
8.7ADRB2, SCN3A, SCN4B, SCN9A, SCN8A
7
Show member pathways
8.5TAC1, SCN3A, SCN4B, SCN9A, SCN8A
8
Show member pathways
7.8PNOC, GPER1, ADRB2, GAL, TAC1
9
Show member pathways
7.3PNOC, GPER1, NGF, ADRB2, GAL, TAC1

Compounds for genes affiliated with Pain Disorder

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Compounds related to Pain Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1atx-ii2810.0SCN8A, SCN3A
2aft-ii2810.0SCN3A, SCN8A
3bc-iii289.9SCN8A, SCN3A
4helospectin439.9TAC1, GAL
5zonisamide43 49 1211.9SCN3A, SCN9A, SCN4B
6clenbuterol43 1210.8NGF, ADRB2
7saxitoxin289.8SCN3A, SCN8A, SCN9A
8batrachotoxin289.8SCN9A, SCN8A, SCN3A
9octadecaneuropeptide439.8GAL, PNOC
10phenoxybenzamine43 1210.8TAC1, ADRB2
11fenoterol43 28 1211.7TAC1, ADRB2
12naloxone43 28 49 1212.6PNOC, GAL, ADRB2
13phrixotoxin 3599.5SCN9A, SCN8A, SCN4B, SCN3A
14tetrodotoxin citrate599.5SCN3A, SCN4B, SCN9A, SCN8A
15guanethidine43 1210.5PNOC, TAC1
16qx 314 chloride599.5SCN3A, SCN4B, SCN9A, SCN8A
17veratridine43 59 2811.5SCN3A, SCN4B, SCN9A, SCN8A
18theophylline43 28 24 1212.4TAC1, ADRB2, NGF
19propranolol43 28 49 24 1213.4TAC1, NGF, ADRB2
20baclofen43 1210.4PNOC, TAC1
21levodopa43 1210.4TAC1, GAL, NGF
22amphetamine43 49 1211.4PNOC, GAL, TAC1
23ltd4439.3GAL, TAC1
24carbachol43 28 1211.2TAC1, ADRB2, NGF, GAL
25epinephrine43 24 1211.1GAL, NGF, TAC1, ADRB2
26opiate439.1PNOC, ADRB2, GAL, TAC1
27cocaine43 1210.1GAL, ADRB2, NGF, PNOC
285-hydroxytryptamine439.1TAC1, GAL, ADRB2, PNOC
29phosphoinositide439.0TAC1, NGF, ADRB2, GAL
30gaba439.0PNOC, TAC1, GAL, ADRB2
31capsaicin43 289.9TAC1, PNOC, GAL, NGF
32atropine43 28 1210.9NGF, GAL, TAC1, PNOC
33pge2438.9TAC1, PNOC, GAL, ADRB2
34tetrodotoxin43 59 2810.7TAC1, GAL, SCN3A, SCN9A, SCN4B, SCN8A
35testosterone43 59 24 1211.7GAL, NGF, ADRB2, TAC1
36potassium43 24 1210.6PNOC, TAC1, GAL, ADRB2, SCN8A
37nitric oxide43 24 1210.6PNOC, CABIN1, GAL, ADRB2, TAC1
38morphine43 49 28 1211.6NGF, GAL, TAC1, PNOC, ADRB2
39norepinephrine43 24 1210.6PNOC, NGF, ADRB2, GAL, TAC1
40histamine43 28 2410.6TAC1, GAL, ADRB2, NGF, PNOC
41acetylcholine43 49 28 24 1212.6PNOC, TAC1, GAL, ADRB2, NGF
42forskolin43 49 1210.6TAC1, GAL, ADRB2, NGF, PNOC
43dopamine43 28 24 1211.5GAL, NGF, TAC1, ADRB2, PNOC
44adenylate438.5TAC1, GAL, ADRB2, NGF, PNOC
45cyclic amp43 249.5PNOC, TAC1, GAL, ADRB2, NGF
46glutamate438.5TAC1, GAL, ADRB2, NGF, PNOC
47steroid438.1GPER1, CABIN1, TAC1, PNOC
48estrogen438.1PNOC, TAC1, GAL, ADRB2, GPER1
49sodium43 249.0SCN4B, TAC1, GAL, SCN9A, SCN8A, SCN3A
50calcium43 49 24 1210.3CABIN1, GPER1, GAL, PNOC, TAC1, NGF

GO Terms for genes affiliated with Pain Disorder

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Cellular components related to Pain Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.1SCN3A, SCN4B, SCN9A, SCN8A

Biological processes related to Pain Disorder according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to toxic substanceGO:00096369.7SCN9A, SCN8A
2peripheral nervous system developmentGO:00074229.6SCN8A, NGF
3neuronal action potentialGO:00192289.5SCN9A, GPER1
4sensory perception of painGO:00192339.3TAC1, NGF
5sodium ion transportGO:00068149.3SCN3A, SCN4B, SCN9A, SCN8A
6sodium ion transmembrane transportGO:00357259.3SCN8A, SCN9A, SCN4B, SCN3A
7neuropeptide signaling pathwayGO:00072189.2PNOC, GAL, TAC1
8positive regulation of MAPK cascadeGO:00434109.0ADRB2, GPER1
9positive regulation of apoptotic processGO:00430658.8GPER1, NGF, GAL
10inflammatory responseGO:00069548.2TAC1, GAL, SCN9A, NGF, GPER1

Molecular functions related to Pain Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.5GAL, PNOC
2voltage-gated sodium channel activityGO:00052488.8SCN3A, SCN4B, SCN9A, SCN8A

Products for genes affiliated with Pain Disorder

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Sources for Pain Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet