MCID: PND001
MIFTS: 53

Pain Disorder malady

Rare diseases category

Summaries for Pain Disorder

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MedlinePlus:34 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards based summary: Pain Disorder, also known as microcephaly with spastic diplegia, is related to paroxysmal extreme pain disorder and fibromyalgia, and has symptoms including microcephaly, spastic diplegia and x-linked inheritance. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Selected targets of CREB1. The compounds aft-ii and atx-ii have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and integument.

Disease Ontology:10 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:65 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

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Pain Disorder, Aliases & Descriptions:

Name: Pain Disorder 10 12 45 62
Microcephaly with Spastic Diplegia 43 62
 
Paine Syndrome 43 62
Pain 34


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology10 DOID:0060164
ICD1027 R52, R52.9

Related Diseases for Pain Disorder

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Diseases in the Chronic Pain family:

pain disorder

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1938)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal extreme pain disorder31.0SCN9A
2fibromyalgia30.2TAC1, PNOC
3erythromelalgia30.2SCN8A, SCN9A, SCN3A
4neuropathy30.2TAC1, SCN9A, SCN8A, NGF
5migraine30.1TAC1, PNOC
6pain agnosia30.0PNOC, TAC1
7pheochromocytoma30.0GAL, ADRB2, NGF
8arthritis29.9TAC1, GAL, ADRB2
9schizophrenia29.8PNOC, NGF, TAC1
10ganglioneuroma29.8GAL, NGF
11rhinitis29.8TAC1
12cystitis29.8TAC1, NGF
13alcohol dependence29.8PNOC, NGF, GAL
14cholera29.7NGF, ADRB2, GAL, TAC1
15long qt syndrome29.7SCN3A, SCN4B, SCN8A
16ischemia29.7GAL, ADRB2, PNOC
17respiratory failure29.7ADRB2, TAC1
18neuroendocrine tumor29.7TAC1, GAL
19prolactinoma29.5GAL, NGF
20brugada syndrome29.4SCN4B, SCN8A
21atopic dermatitis29.4CABIN1, NGF
22carcinoid syndrome29.4TAC1, GAL, NGF
23psoriasis29.4TAC1, ADRB2, NGF
24hypersensitivity reaction type ii disease29.4ADRB2, GAL, TAC1
25malignant glioma29.4PNOC, NGF, ADRB2, GAL, TAC1
26complex regional pain syndrome11.2
27patellofemoral pain syndrome11.1
28myofascial pain syndrome11.0
29prostatitis10.9
30complex regional pain syndrome type 110.8
31diabetic neuropathy10.7
32osteoarthritis10.7
33reflex sympathetic dystrophy10.7
34anhidrosis10.6
35radiculopathy10.6
36pancreatitis10.5
37neuroma10.5
38ophthalmoplegia10.5
39causalgia10.5
40herpes zoster10.5
41sickle cell disease10.5
42spinal stenosis10.5
43bone cancer10.5
44diabetic polyneuropathy10.4
45cervicitis10.4
46dystonia10.4
47chronic pain10.4
48spinal cord injury10.4
49spasticity10.4
50insensitivity to pain, congenital, with anhidrosis10.4

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Symptoms for Pain Disorder

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HPO human phenotypes related to Pain Disorder:

id Description Frequency HPO Source Accession
1 microcephaly HP:0000252
2 spastic diplegia HP:0001264
3 x-linked inheritance HP:0001417
4 generalized myoclonic seizures HP:0002123
5 olivopontocerebellar hypoplasia HP:0006955

Drugs & Therapeutics for Pain Disorder

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Drug clinical trials:

Search ClinicalTrials for Pain Disorder

Search NIH Clinical Center for Pain Disorder

Genetic Tests for Pain Disorder

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Anatomical Context for Pain Disorder

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Animal Models for Pain Disorder or affiliated genes

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MGI Mouse Phenotypes related to Pain Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4ADRB2, SCN3A, NGF, GPER1
2MP:00107718.2PNOC, NGF, SCN9A, GAL, TAC1
3MP:00053787.5GPER1, NGF, SCN8A, SCN3A, ADRB2, GAL
4MP:00053857.5GPER1, NGF, SCN8A, ADRB2, TAC1
5MP:00053867.1TAC1, PNOC, NGF, SCN8A, SCN9A, SCN3A

Publications for Pain Disorder

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Articles related to Pain Disorder:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Prevalence of restless legs syndrome in somatoform pain disorder and its effect on quality of life. (25883472)
2015
2
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. (23689753)
2014
3
Restless legs syndrome and pain disorders: what's in common? (25249423)
2014
4
Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. (24817410)
2014
5
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. (24428222)
2014
6
Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: a preliminary resting-state fMRI study. (24439113)
2014
7
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. (23893323)
2014
8
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. (24179828)
2013
9
Predicting return to work following treatment of chronic pain disorder. (23503298)
2013
10
Paroxysmal extreme pain disorder. (23599527)
2013
11
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. (23738195)
2012
12
The causes and prevalence of vestibulodynia: a vulvar pain disorder. (21542444)
2011
13
Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. (21079636)
2011
14
Case reports: anesthesia for a patient with paroxysmal extreme pain disorder. (20435947)
2010
15
Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study. (20727111)
2010
16
Post-traumatic external nasal pain syndrome (a trigeminal based pain disorder). (19619239)
2009
17
The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale. (19349078)
2009
18
Memory performance related to organic and psychosocial illness attributions in somatoform pain disorder patients. (19686875)
2009
19
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. (19733606)
2009
20
Nondermatomal somatosensory deficits in patients with chronic pain disorder: clinical findings and hypometabolic pattern in FDG-PET. (19500908)
2009
21
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. (17723312)
2008
22
Redefining (somatoform) pain disorder in ICD-10: a compromise of different interest groups in Germany. (18332667)
2008
23
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. (18803825)
2008
24
Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. (18599537)
2008
25
Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study. (17428684)
2007
26
From genes to pain: Na v 1.7 and human pain disorders. (17950472)
2007
27
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. (17145499)
2006
28
Re: Goldby LJ, Moore AP, Doust J, et al. A randomized control trial investigating the efficiency of musculoskeletal physiotherapy on chronic back pain disorder. Spine 2006;31:1083-93. (16985474)
2006
29
A controlled study of alexithymia in adolescent patients with persistent somatoform pain disorder. (16838829)
2006
30
Chronic pain disorder manifesting as dental pain: case report. (16512099)
2006
31
What does the WHOQOL-Bref measure? Measurement overlap between quality of life and depressive symptomatology in chronic somatoform pain disorder. (16341612)
2006
32
Dyspareunia: a pain disorder or sexual dysfunction? (16092026)
2005
33
Vulvar disease: a pelvic floor pain disorder? (15970821)
2005
34
Somatoform pain disorder: a valid diagnosis? (12807381)
2003
35
A preliminary open-label study of moclobemide treatment of pain disorder. (14608245)
2003
36
Sleep disturbances in somatoform pain disorder. (14707439)
2003
37
Chronic pain disorder associated with psychogenic versus somatic factors: a comparative study. (12745793)
2003
38
Does nociceptin play a role in pain disorders in man? (12217418)
2002
39
Hypnorelaxation as treatment for myofascial pain disorder: a comparative study. (12029281)
2002
40
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
41
Interactions of a history of migration with the course of pain disorder. (11399284)
2001
42
Vaginismus is better not included in sexual pain disorder. (11247223)
2001
43
Treatment of functional impairment in severe somatoform pain disorder: a case example. (11553697)
2001
44
Chronic pain disorder following physical injury. (10849455)
2000
45
Onchologic stress: its causality in myofascial pain disorder or in temporomandibular disorder. (9543900)
1998
46
Where have two DSM revisions taken us for the diagnosis of pain disorder in chronic pain patients? (8540581)
1996
47
Difficulties in the differential diagnosis of vaginismus, dyspareunia and mixed sexual pain disorder. (8748995)
1995
48
Psychiatric consequences of road traffic accidents. Consider somatoform pain disorder. (8281072)
1993
49
Chronic idiopathic pain disorder. (3723450)
1986
50
idiopathic pain disorder: a critique of pain-prone disorder and a proposal for a revision of the DSM-III category psychogenic pain disorder. (7086398)
1982

Variations for Pain Disorder

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Expression for genes affiliated with Pain Disorder

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Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

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Pathways related to Pain Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SCN4B, ADRB2
29.5GAL, PNOC
3
Show member pathways
9.4SCN8A, SCN9A, SCN3A
4
Show member pathways
9.4SCN3A, SCN9A, SCN8A
59.4SCN3A, SCN9A, SCN8A
69.1TAC1, SCN4B, NGF
7
Show member pathways
9.1SCN3A, SCN4B, SCN9A, SCN8A
8
Show member pathways
8.7ADRB2, SCN3A, SCN4B, SCN9A, SCN8A
9
Show member pathways
8.5TAC1, SCN3A, SCN4B, SCN9A, SCN8A
10
Show member pathways
7.8PNOC, GPER1, ADRB2, GAL, TAC1
11
Show member pathways
7.3PNOC, GPER1, NGF, ADRB2, GAL, TAC1

Compounds for genes affiliated with Pain Disorder

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Compounds related to Pain Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1aft-ii3010.0SCN3A, SCN8A
2atx-ii3010.0SCN3A, SCN8A
3bc-iii309.9SCN3A, SCN8A
4helospectin459.9GAL, TAC1
5zonisamide45 51 1311.9SCN3A, SCN4B, SCN9A
6clenbuterol45 1310.8NGF, ADRB2
7saxitoxin309.8SCN3A, SCN9A, SCN8A
8batrachotoxin309.8SCN8A, SCN9A, SCN3A
9octadecaneuropeptide459.8GAL, PNOC
10phenoxybenzamine45 1310.8TAC1, ADRB2
11fenoterol45 30 1311.7ADRB2, TAC1
12naloxone45 30 51 1312.6GAL, ADRB2, PNOC
13tetrodotoxin citrate619.5SCN8A, SCN9A, SCN4B, SCN3A
14qx 314 chloride619.5SCN3A, SCN4B, SCN9A, SCN8A
15guanethidine45 1310.5PNOC, TAC1
16phrixotoxin 3619.5SCN8A, SCN9A, SCN4B, SCN3A
17veratridine45 61 3011.5SCN8A, SCN9A, SCN4B, SCN3A
18theophylline45 30 26 1312.4NGF, ADRB2, TAC1
19propranolol45 30 51 26 1313.4TAC1, ADRB2, NGF
20baclofen45 1310.4TAC1, PNOC
21levodopa45 1310.4NGF, GAL, TAC1
22amphetamine45 51 1311.4PNOC, GAL, TAC1
23ltd4459.3TAC1, GAL
24carbachol45 30 1311.2NGF, ADRB2, GAL, TAC1
25epinephrine45 26 1311.1NGF, ADRB2, GAL, TAC1
26opiate459.1PNOC, ADRB2, GAL, TAC1
27cocaine45 1310.1GAL, ADRB2, NGF, PNOC
285-hydroxytryptamine459.1PNOC, ADRB2, GAL, TAC1
29phosphoinositide459.0TAC1, GAL, ADRB2, NGF
30gaba459.0PNOC, ADRB2, GAL, TAC1
31capsaicin45 309.9TAC1, GAL, NGF, PNOC
32atropine45 30 1310.9PNOC, NGF, GAL, TAC1
33pge2458.9PNOC, ADRB2, GAL, TAC1
34tetrodotoxin45 61 3010.7TAC1, GAL, SCN3A, SCN4B, SCN9A, SCN8A
35testosterone45 61 26 1311.7NGF, ADRB2, GAL, TAC1
36potassium45 26 1310.6TAC1, GAL, ADRB2, SCN8A, PNOC
37nitric oxide45 26 1310.6TAC1, GAL, CABIN1, ADRB2, PNOC
38morphine45 51 30 1311.6PNOC, NGF, ADRB2, GAL, TAC1
39norepinephrine45 26 1310.6TAC1, GAL, ADRB2, NGF, PNOC
40histamine45 30 2610.6PNOC, NGF, ADRB2, GAL, TAC1
41acetylcholine45 51 30 26 1312.6PNOC, NGF, ADRB2, GAL, TAC1
42forskolin45 51 1310.6PNOC, NGF, ADRB2, GAL, TAC1
43dopamine45 30 26 1311.5TAC1, GAL, ADRB2, NGF, PNOC
44adenylate458.5PNOC, NGF, ADRB2, GAL, TAC1
45cyclic amp45 269.5PNOC, NGF, ADRB2, GAL, TAC1
46glutamate458.5PNOC, NGF, ADRB2, GAL, TAC1
47steroid458.1TAC1, CABIN1, GPER1, PNOC
48estrogen458.1PNOC, GPER1, ADRB2, GAL, TAC1
49sodium45 269.0PNOC, SCN8A, SCN9A, SCN4B, SCN3A, GAL
50calcium45 51 26 1310.3PNOC, GPER1, NGF, CABIN1, GAL, TAC1

GO Terms for genes affiliated with Pain Disorder

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Cellular components related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.1SCN3A, SCN4B, SCN9A, SCN8A

Biological processes related to Pain Disorder according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to toxic substanceGO:00096369.7SCN9A, SCN8A
2peripheral nervous system developmentGO:00074229.6SCN8A, NGF
3neuronal action potentialGO:00192289.5SCN9A, GPER1
4sensory perception of painGO:00192339.3TAC1, NGF
5sodium ion transportGO:00068149.3SCN3A, SCN4B, SCN9A, SCN8A
6sodium ion transmembrane transportGO:00357259.3SCN8A, SCN9A, SCN4B, SCN3A
7neuropeptide signaling pathwayGO:00072189.2PNOC, GAL, TAC1
8positive regulation of MAPK cascadeGO:00434109.0ADRB2, GPER1
9positive regulation of apoptotic processGO:00430658.8GPER1, NGF, GAL
10inflammatory responseGO:00069548.2TAC1, GAL, SCN9A, NGF, GPER1

Molecular functions related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.5GAL, PNOC
2voltage-gated sodium channel activityGO:00052488.8SCN3A, SCN4B, SCN9A, SCN8A

Products for genes affiliated with Pain Disorder

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Sources for Pain Disorder

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet