PAIN
MCID: PND001
MIFTS: 49

Pain Disorder (PAIN) malady

Summaries for Pain Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards: Pain Disorder, also known as PAIN, is related to erythromelalgia and fibromyalgia. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Interaction between L1 and Ankyrins and Sodium channels and transporters: inward current. The compounds Lacosamide and aft-ii have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and thyroid, and related mouse phenotypes are integument and behavior/neurological.

Disease Ontology:8 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:64 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 25ICD10
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Related Diseases for Pain Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pain Disorder family:

chronic pain

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1644)
idRelated DiseaseScoreTop Affiliating Genes
1erythromelalgia30.1SCN3A, SCN8A, SCN9A
2fibromyalgia30.1PNOC, TAC1
3pain agnosia29.9PNOC, TAC1
4ganglioneuroma29.7NGF, GAL
5parkinson's disease29.6ADRB2, TAC1, NGF, GAL
6atopic dermatitis29.3NGF, CABIN1
7brugada syndrome29.3SCN8A, SCN4B
8carcinoid syndrome29.3GAL, NGF, TAC1
9cholera29.3ADRB2, TAC1, NGF, GAL
10patellofemoral pain syndrome10.8
11myofascial pain syndrome10.8
12whiplash10.7
13osteoarthritis10.7
14somatoform disorder10.6
15anhidrosis10.6
16central post-stroke pain10.6
17postherpetic neuralgia10.6
18headache10.5
19reflex sympathetic dystrophy10.5
20paroxysmal extreme pain disorder10.5
21arthritis10.5
22radiculopathy10.5
23chronic pain10.5
24causalgia10.5
25trigeminal neuralgia10.5
26herpes zoster10.4
27spinal stenosis10.4
28sickle cell disease10.4
29plantar fasciitis10.4
30lumbar disc herniation10.4
31spinal cord injury10.4
32diabetic polyneuropathy10.4
33loin pain hematuria syndrome10.4
34chronic interstitial cystitis10.4
35chronic fatigue syndrome10.4
36pancreatitis, chronic10.4
37rheumatic disease10.3
38tendinopathy10.3
39tolosa-hunt syndrome10.3
40syringomyelia10.3
41char syndrome10.3
42hereditary sensory and autonomic neuropathy iv10.3
43carpal tunnel syndrome10.3
44appendicitis10.3
45irritable bowel syndrome10.3
46pulpitis10.3
47sickle cell anemia10.3
48degenerative disc disease10.3
49synovitis10.3
50adult syndrome10.3

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Clinical Features for Pain Disorder

Drugs & Therapeutics for Pain Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pain Disorder

Drug clinical trials:

Search ClinicalTrials for Pain Disorder

Search NIH Clinical Center for Pain Disorder

Search CenterWatch for Pain Disorder

Genetic Tests for Pain Disorder

Anatomical Context for Pain Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pain Disorder:

33
Spinal cord, Brain, Thyroid, Breast, Prostate, T cells, Trigeminal ganglion, Pituitary

Animal Models for Pain Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pain Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0PNOC, TAC1, NGF, GAL, SCN9A
2MP:00053866.6ADRB2, SCN3A, SCN8A, SCN9A, GAL, NGF

Publications for Pain Disorder

Sources:
51PubMed
See all sources

Articles related to Pain Disorder:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder. (24038135)
2014
2
Pain conditions among veterans with schizophrenia or bipolar disorder. (23639185)
2013
3
Authors' response to the letter to the editor: "Pain in primary care patients with bipolar disorder" (24359679)
2013
4
Interrelationships between pain processing, cortisol and cognitive performance in chronic whiplash-associated disorders. (24337691)
2013
5
Self-Reported Pain Complaints among Afghanistan/Iraq Era Men and Women Veterans with Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder. (23924351)
2013
6
Panic disorder in children and adolescents with noncardiac chest pain. (23378228)
2013
7
Pain and post-traumatic stress disorder symptoms during inpatient rehabilitation among operation enduring freedom/operation iraqi freedom veterans with spinal cord injury. (22864017)
2013
8
Alterations in Pain Response are Partially Reversed by Methylphenidate (Ritalin) in Adults with Attention Deficit Hyperactivity Disorder (ADHD). (24134430)
2013
9
Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder. (23497482)
2013
10
Knee pain: an unanticipated finding related to a rare genetic disorder--abetalipoproteinemia. (24170593)
2013
11
The trade-off between costs and quality of care in the treatment of psychosomatic patients with somatoform pain disorder. (23852985)
2013
12
The influence of myofascial temporomandibular disorder pain on the pressure pain threshold of women during a migraine attack. (24171184)
2013
13
Prevalence and predictors of pain in patients with major depressive disorder. (23810134)
2013
14
Effect of contingent electrical stimulation on masticatory muscle activity and pain in patients with a myofascial temporomandibular disorder and sleep bruxism. (23424717)
2013
15
Association between chronic prostatitis/chronic pelvic pain syndrome and anxiety disorder: a population-based study. (23691256)
2013
16
Autonomic response to pain in patients with chronic whiplash associated disorders. (23703426)
2013
17
Alterations in default mode network connectivity during pain processing in borderline personality disorder. (22637967)
2012
18
Lack of endogenous pain inhibition during exercise in people with chronic whiplash associated disorders: an experimental study. (22277322)
2012
19
Relationship between pressure pain thresholds and pain ratings in patients with whiplash-associated disorders. (21415717)
2011
20
Rheumatic-musculoskeletal pain and disorders in a naA^ve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study. (22093538)
2011
21
Transient psychosis due to painless thyroiditis in a patient with anxiety disorder: a case report. (22040466)
2011
22
Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study. (20727111)
2010
23
Can patients with low energy whiplash associated disorder develop low back pain? (19625019)
2010
24
Pain sensitivity is reduced in borderline personality disorder, but not in posttraumatic stress disorder and bulimia nervosa. (20218798)
2010
25
Effectiveness of milnacipran for a patient with pain disorder and long QT syndrome. (20173629)
2010
26
Causal symptom attributions in somatoform disorder and chronic pain. (20004296)
2010
27
Post-traumatic external nasal pain syndrome (a trigeminal based pain disorder). (19619239)
2009
28
Redefining (somatoform) pain disorder in ICD-10: a compromise of different interest groups in Germany. (18332667)
2008
29
Association between tryptophan hydroxylase gene polymorphism and painful non-osseous temporomandibular disorders. (18813430)
2008
30
Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. (18599537)
2008
31
Assessing pain perception using the Painmatcher in patients with whiplash-associated disorders. (18292917)
2008
32
Generalized pain is associated with more negative consequences than local or regional pain: a study of chronic whiplash-associated disorders. (17468796)
2007
33
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. (18060017)
2007
34
Sexual dysfunction or pain disorder?: dyspareunia from the perspective of the harmful dysfunction analysis. (16092035)
2005
35
Review of aetiological concepts of temporomandibular pain disorders: towards a biopsychosocial model for integration of physical disorder factors with psychological and psychosocial illness impact factors. (15978854)
2005
36
Trauma and dissociation in conversion disorder and chronic pelvic pain. (15825581)
2004
37
A preliminary open-label study of moclobemide treatment of pain disorder. (14608245)
2003
38
Childhood adversities in patients with fibromyalgia and somatoform pain disorder. (12600792)
2003
39
Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6. (12435463)
2002
40
Hypnorelaxation as treatment for myofascial pain disorder: a comparative study. (12029281)
2002
41
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
42
Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. (11719521)
2002
43
How could the validity of the DSM-IV pain disorder be improved in reference to the concept that it is supposed to identify? (11749874)
2002
44
Psychological functioning and bodily conditions in patients with pain disorder associated with psychological factors. (11802835)
2001
45
Is the term "pain disorder" a valid diagnosis? (10953280)
2000
46
Are pain disorder and somatization disorder valid diagnostic entities? (10953279)
2000
47
Psychiatric consequences of road traffic accidents. Consider somatoform pain disorder. (8281072)
1993
48
Controlled study of alexithymic characteristics in patients with psychogenic pain disorder. (3438440)
1987
49
Chronic idiopathic pain disorder. (3723450)
1986
50
Behavior modification of abnormal gait and chronic pain secondary to somatization disorder. (3970659)
1985

Genetic Variations for Pain Disorder

Expression for genes affiliated with Pain Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Pain Disorder

Sources:
11DrugBank, 29IUPHAR, 45Novoseek, 50PharmGKB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Pain Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Lacosamide1110.2SCN9A, SCN3A
2aft-ii2910.1SCN3A, SCN8A
3bc-iii2910.1SCN3A, SCN8A
4atx-ii2910.1SCN3A, SCN8A
5clenbuterol45 1110.9ADRB2, NGF
6saxitoxin299.9SCN3A, SCN8A, SCN9A
7batrachotoxin299.9SCN9A, SCN8A, SCN3A
8gnrh459.9ADRB2, GAL
9octadecaneuropeptide459.8PNOC, GAL
10zonisamide45 1110.7SCN9A, SCN4B, SCN3A
11helospectin459.7TAC1, GAL
12naloxone45 50 29 1112.6ADRB2, PNOC, GAL
13phenoxybenzamine45 1110.5TAC1, ADRB2
14fenoterol45 29 1111.5ADRB2, TAC1
15tetrodotoxin citrate609.4SCN3A, SCN4B, SCN8A, SCN9A
16qx 314 chloride609.4SCN9A, SCN8A, SCN4B, SCN3A
17phrixotoxin 3609.4SCN3A, SCN4B, SCN8A, SCN9A
18veratridine45 60 2911.4SCN3A, SCN4B, SCN8A, SCN9A
19guanethidine45 1110.3PNOC, TAC1
20ltd4459.3TAC1, GAL
21theophylline45 29 11 2412.2ADRB2, TAC1, NGF
22propranolol45 29 50 11 2413.2NGF, TAC1, ADRB2
23cocaine45 1110.2GAL, NGF, PNOC, ADRB2
24levodopa45 1110.2TAC1, NGF, GAL
25amphetamine45 1110.1PNOC, TAC1, GAL
26baclofen45 1110.0PNOC, TAC1
27carbachol45 29 1111.0ADRB2, TAC1, NGF, GAL
28epinephrine45 11 2410.9GAL, NGF, TAC1, ADRB2
29opiate458.8ADRB2, PNOC, TAC1, GAL
30phosphoinositide458.8GAL, NGF, TAC1, ADRB2
315-hydroxytryptamine458.8GAL, TAC1, PNOC, ADRB2
32gaba458.8GAL, TAC1, PNOC, ADRB2
33capsaicin45 299.7GAL, NGF, TAC1, PNOC
34atropine45 29 1110.7GAL, NGF, TAC1, PNOC
35pge2458.5ADRB2, PNOC, TAC1, GAL
36potassium45 11 2410.4SCN8A, GAL, TAC1, PNOC, ADRB2
37morphine45 50 29 1111.4ADRB2, PNOC, TAC1, NGF, GAL
38norepinephrine45 11 2410.4GAL, NGF, TAC1, PNOC, ADRB2
39histamine45 29 2410.4GAL, NGF, TAC1, PNOC, ADRB2
40acetylcholine45 50 29 11 2412.4ADRB2, PNOC, TAC1, NGF, GAL
41forskolin45 50 1110.4ADRB2, PNOC, TAC1, NGF, GAL
42dopamine45 29 11 2411.3GAL, NGF, TAC1, PNOC, ADRB2
43adenylate458.3GAL, NGF, TAC1, PNOC, ADRB2
44nitric oxide45 11 2410.3CABIN1, GAL, TAC1, PNOC, ADRB2
45cyclic amp45 249.3GAL, NGF, TAC1, PNOC, ADRB2
46testosterone45 60 11 2411.3GAL, NGF, TAC1, ADRB2
47tetrodotoxin45 60 2910.2TAC1, GAL, SCN9A, SCN8A, SCN4B, SCN3A
48glutamate458.2GAL, NGF, TAC1, PNOC, ADRB2
49estrogen458.0GAL, TAC1, GPER1, PNOC, ADRB2
50sodium45 248.6SCN3A, SCN4B, SCN8A, SCN9A, GAL, TAC1

GO Terms for genes affiliated with Pain Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015188.9SCN9A, SCN8A, SCN4B, SCN3A

Biological processes related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of action potential in neuronGO:0192289.6GPER1, SCN9A
2peripheral nervous system developmentGO:0074229.3NGF, SCN8A
3positive regulation of apoptotic processGO:0430659.2GPER1, NGF, GAL
4sodium ion transportGO:0068149.0SCN9A, SCN8A, SCN4B, SCN3A
5neuropeptide signaling pathwayGO:0072188.7GAL, TAC1, PNOC
6inflammatory responseGO:0069548.7TAC1, NGF, GAL, SCN9A

Molecular functions related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6PNOC, GAL
2voltage-gated sodium channel activityGO:0052488.6SCN9A, SCN8A, SCN4B, SCN3A

Products for genes affiliated with Pain Disorder

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Sources for Pain Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet