PAIN
MCID: PND001
MIFTS: 54

Pain Disorder (PAIN) malady

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Pain Disorder

Aliases & Descriptions for Pain Disorder:

Name: Pain Disorder 12 52 14 69
Paine Syndrome 50 29 69
Microcephaly with Spastic Diplegia 50
Pain Syndrome 14
Pain 41

Characteristics:

HPO:

32
pain disorder:
Inheritance x-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0060164
ICD10 33 R52 R52.9

Summaries for Pain Disorder

MedlinePlus : 41 pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen, chest, or pelvis. or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture, and sometimes surgery are helpful.

MalaCards based summary : Pain Disorder, also known as paine syndrome, is related to paroxysmal extreme pain disorder and complex regional pain syndrome, and has symptoms including microcephaly, generalized myoclonic seizures and spastic diplegia. An important gene associated with Pain Disorder is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Acetaminophen and Amitriptyline have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia : 71 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Related Diseases for Pain Disorder

Diseases in the Chronic Pain family:

Pain Disorder Central Pain Syndrome

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 paroxysmal extreme pain disorder 33.4 SCN10A SCN11A SCN9A
2 complex regional pain syndrome 12.2
3 central pain syndrome 12.1
4 patellofemoral pain syndrome 12.1
5 myofascial pain syndrome 12.1
6 episodic pain syndrome, familial 12.1
7 episodic pain syndrome, familial, 3 12.0
8 episodic pain syndrome, familial, 2 12.0
9 erythromelalgia 10.7
10 arachnoiditis 10.4
11 trigeminal neuralgia 10.3
12 malignant renovascular hypertension 10.2 NGF TAC1
13 pseudoinflammatory fundus dystrophy 10.2 NGF TAC1
14 dilated cardiomyopathy 10.2 NGF SCN9A TRPV1
15 ocular hypertension 10.2 SCN4B SCN9A
16 porencephaly, cerebellar hypoplasia, and internal malformations 10.1 ATP4A CABIN1
17 uterine ligament serous adenocarcinoma 10.1 NGF TAC1 TRPV1
18 neovascular glaucoma 10.1 NGF TAC1 TRPV1
19 oculogyric crisis 10.1 ATP4A TAC1
20 inhalation anthrax 10.1 ATP4A TAC1 TRPV1
21 adenosquamous bile duct carcinoma 10.1 SCN11A TAC1
22 deafness, autosomal recessive 20 10.1 ATP4A TAC1 TRPV1
23 synostosis 10.1 ATP4A CABIN1 NGF
24 uterine corpus dissecting leiomyoma 10.1 ADRB2 NGF TAC1 TRPV1
25 hypermobility of coccyx 10.0 NGF SCN10A
26 lacrimal apparatus disease 10.0 ATP4A IL1B
27 uterine ligament clear cell adenocarcinoma 10.0 IL1B TAC1 TRPV1
28 childhood intracortical osteosarcoma 10.0 ATP4A IL1B TRPV1
29 spontaneous ocular nystagmus 10.0 ADRB2 IL1B TAC1
30 apodia, unilateral 10.0 SCN10A SCN11A SCN9A
31 anal paget's disease 10.0 ATP4A IL1B
32 acrocephalopolydactylous dysplasia 10.0 SCN10A SCN11A SCN9A
33 gastroduodenal crohn's disease 10.0 ATP4A IL1B NGF
34 acute chest syndrome 10.0 ADRB2 IL1B TAC1
35 brain compression 10.0 NGF SCN10A TRPV1
36 brain injury 10.0 NGF P2RX2 TAC1 TRPV1
37 chronic pain 10.0
38 connective tissue cancer 10.0 NGF SCN10A TRPV1
39 childhood malignant hemangiopericytoma 9.9 ATP4A IL1B TRPV1
40 childhood endodermal sinus tumor 9.9 IL1B SCN11A TAC1 TRPV1
41 charcot-marie-tooth disease, axonal, type 2h 9.9 SCN10A SCN11A TRPA1
42 jejunoileitis 9.9 ATP4A IL1B
43 auriculocondylar syndrome 1 9.9 NGF SCN10A SCN11A SCN9A
44 tinea capitis 9.8 IL1B NGF SCN9A TAC1 TRPV1
45 febrile seizures, familial, 3b 9.8 SCN10A SCN11A SCN4B SCN9A TRPV1
46 nemaline myopathy 2, autosomal recessive 9.8 ADRB2 IL1B NGF TAC1 TRPV1
47 substance-induced psychosis 9.7 IL1B NGF TAC1
48 cerebritis 9.6
49 restless legs syndrome 9.6
50 testicular leydig cell tumor 9.6 CABIN1 IL1B NGF SCN9A TAC1 TRPA1

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to Pain Disorder

Symptoms & Phenotypes for Pain Disorder

Human phenotypes related to Pain Disorder:

32
id Description HPO Frequency HPO Source Accession
1 microcephaly 32 HP:0000252
2 generalized myoclonic seizures 32 HP:0002123
3 spastic diplegia 32 HP:0001264
4 olivopontocerebellar hypoplasia 32 HP:0006955

MGI Mouse Phenotypes related to Pain Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 ADRB2 CLP1 NGF SCN10A SCN11A SCN9A
2 cardiovascular system MP:0005385 9.97 LAPTM4A NGF P2RX2 SCN10A TAC1 TRPV1
3 immune system MP:0005387 9.97 ADRB2 ATP4A CABIN1 CLP1 IL1B P2RX2
4 integument MP:0010771 9.91 CLP1 IL1B NGF SCN10A SCN11A SCN9A
5 nervous system MP:0003631 9.9 IL1B LAPTM4A NGF P2RX2 SCN10A SCN11A
6 no phenotypic analysis MP:0003012 9.43 ADRB2 CLP1 NGF SCN10A TRPA1 TRPV1
7 taste/olfaction MP:0005394 8.8 SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Pain Disorder

Drugs for Pain Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1242)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
2
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1 50-48-6 2160
3
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2 303-53-7 2895
4
Hydrocodone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 125-29-1 5284569
5
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
6
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 76-42-6 5284603
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
9
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
10
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 202409-33-4 123619
11
Diphenhydramine Approved Phase 4,Phase 3,Phase 2,Phase 1 58-73-1, 147-24-0 3100
12
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-27-2 5288826
14
Promethazine Approved Phase 4,Phase 3,Phase 2,Phase 1 60-87-7 4927
15
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 2078-54-8 4943
16
Tetracaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 94-24-6 5411
17
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 27203-92-5 33741
18
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
19
Coal tar Approved Phase 4 8007-45-2
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-84-3 187
21
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
22
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 15307-86-5 3033
23
Levobupivacaine Approved Phase 4,Phase 3 27262-47-1 92253
24
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
25
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
26
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 466-99-9 5284570
27
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 76-57-3 5284371
28
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 93-14-1 3516
29
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
30
Nepafenac Approved Phase 4 78281-72-8 151075
31
Lansoprazole Approved, Investigational Phase 4,Phase 1,Phase 2 103577-45-3 3883
32
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 148553-50-8 5486971
33
Dinoprostone Approved Phase 4 363-24-6 5280360
34
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
35
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
36
Terbutaline Approved Phase 4,Phase 2 23031-25-6 5403
37
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
38 Parecoxib Approved Phase 4,Phase 2,Phase 3 198470-84-7
39
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 84057-95-4 71273 175805
40
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-28-2 5757 53477783
41
Ziconotide Approved Phase 4,Phase 3,Phase 2 107452-89-1 447451
42
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
43
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
44
Rocuronium Approved Phase 4,Phase 2 119302-91-9, 143558-00-3 441290
45
Haloperidol Approved Phase 4 52-86-8 3559
46
Meperidine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 57-42-1 4058
47
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
48
Capsaicin Approved Phase 4,Phase 2,Phase 3,Phase 1 404-86-4 1548943
49
Dezocine Approved Phase 4 53648-55-8 40841 3033053
50
Flurbiprofen Approved, Investigational Phase 4,Phase 2 5104-49-4 3394

Interventional clinical trials:

(show top 50) (show all 8743)
id Name Status NCT ID Phase
1 A Randomized Study of Three Medication Regimens for Acute Low Back Pain Unknown status NCT01587274 Phase 4
2 Paracervical Block for Pain Control in First Trimester Abortion Unknown status NCT01094366 Phase 4
3 Memantine for Post-Operative Pain Control Unknown status NCT01041313 Phase 4
4 Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain Unknown status NCT01344720 Phase 4
5 Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department Unknown status NCT01129934 Phase 4
6 In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction? Unknown status NCT01576770 Phase 4
7 Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain on Postoperative Pain Unknown status NCT02252614 Phase 4
8 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4
9 Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain Unknown status NCT00444990 Phase 4
10 Effect of Three Therapeutics Strategies on Patients With a Chronic Back Pain (PLURICLEF). Unknown status NCT02030171 Phase 4
11 Two Different Surgical Techniques on Postoperative Circumcision Pain Unknown status NCT01909765 Phase 4
12 Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain Unknown status NCT00404417 Phase 4
13 Intraperitoneal Atomization of Levobupivacaine During Gynaecological Laparoscopic Procedures ; Impact on Pain, Opioid Use and Length of Recovery Room Stay (IPLA). Unknown status NCT01886352 Phase 4
14 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Unknown status NCT02289261 Phase 4
15 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4
16 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain Unknown status NCT01920971 Phase 4
17 Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain Unknown status NCT00305058 Phase 4
18 Postoperative Analgesia in Laminectomy Unknown status NCT02255955 Phase 4
19 Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Unknown status NCT00869219 Phase 4
20 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
21 The Effect of Intravenous Lidocaine on Pain After Thyroidectomy Unknown status NCT01608360 Phase 4
22 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
23 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain Unknown status NCT02125968 Phase 4
24 Effect of Pulsed Electromagnetic Field Therapy on Pain After Cesarean Delivery Unknown status NCT02365753 Phase 4
25 The Effects of Reducing Stomach Acid on Post-Tonsillectomy Pain Unknown status NCT00472186 Phase 4
26 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4
27 The Effect of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation on Pain After Laparoscopic Cholecystectomy Unknown status NCT01608373 Phase 4
28 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4
29 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4
30 Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial Unknown status NCT00615875 Phase 4
31 Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery Unknown status NCT00735748 Phase 4
32 Sucking and Sucrose as Pain Relief for Infants Unknown status NCT00805623 Phase 4
33 Double-Blind Placebo Study on Magnetic Field Therapy in Chronic Lumbar Pain Unknown status NCT00407615 Phase 4
34 Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain Unknown status NCT01967017 Phase 4
35 Use of ThermaCare Heat Wraps and Ibuprofen as an Adjunct to Physical Therapy for Neck Pain Unknown status NCT02327338 Phase 4
36 Intranasal Ketorolac Tromethamine (SPRIX) as a Short Term Pain Management of Post-Vasectomy Pain Unknown status NCT02000388 Phase 4
37 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Unknown status NCT02097017 Phase 4
38 Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols Unknown status NCT00742807 Phase 4
39 Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement Unknown status NCT01651962 Phase 4
40 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4
41 The Use of Intranasal Ketoralac for Pain Management Unknown status NCT01736358 Phase 4
42 IV Acetaminophen for Acute Post Operative Pain in C-Section Patients Unknown status NCT02069184 Phase 4
43 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
44 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4
45 Effect of Celecoxib on Transitional Pain After Outpatient Surgery Unknown status NCT00664690 Phase 4
46 The Effect of Intravenous Lidocaine on Pain After Tonsillectomy Unknown status NCT01291979 Phase 4
47 Effect Study of Parecoxib to Treat Emergence Delirium and Postoperative Pain Unknown status NCT01221025 Phase 4
48 A Preemptive Epidural Ropivacaine for Postoperative Pain Relief in Degenerative Lumbar Spine Surgery Unknown status NCT01117610 Phase 4
49 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4
50 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department Unknown status NCT01538745 Phase 4

Search NIH Clinical Center for Pain Disorder

Genetic Tests for Pain Disorder

Genetic tests related to Pain Disorder:

id Genetic test Affiliating Genes
1 Pain 29

Anatomical Context for Pain Disorder

MalaCards organs/tissues related to Pain Disorder:

39
Testes, Brain

Publications for Pain Disorder

Articles related to Pain Disorder:

(show top 50) (show all 140)
id Title Authors Year
1
Altered Spontaneous Activity in Patients with Persistent Somatoform Pain Disorder Revealed by Regional Homogeneity. ( 26977802 )
2016
2
Low Level Laser Therapy Versus Pharmacotherapy in Improving Myofascial Pain Disorder Syndrome. ( 27330698 )
2016
3
Alexithymia in Chronic Pain Disorders. ( 27215759 )
2016
4
Parental Protectiveness Mediates the Association between Parent-Perceived Child Self-Efficacy and Health Outcomes in Pediatric Functional Abdominal Pain Disorder. ( 27657151 )
2016
5
Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study. ( 27641732 )
2016
6
Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder. ( 27525141 )
2016
7
Psychophysiological decoupling in alexithymic pain disorder patients. ( 26804974 )
2016
8
Prevalence of restless legs syndrome in somatoform pain disorder and its effect on quality of life. ( 25883472 )
2015
9
Effects of Kamishoyosan, a Traditional Japanese Kampo Medicine, on Pain Conditions in Patients with Intractable Persistent Dentoalveolar Pain Disorder. ( 26495024 )
2015
10
Bilateral congenital corneal anesthesia in a patient with SCN9A mutation, confirmed primary erythromelalgia, and paroxysmal extreme pain disorder. ( 26486037 )
2015
11
Amplified Brain Processing of Dentoalveolar Pressure Stimulus in Persistent Dentoalveolar Pain Disorder Patients. ( 26485382 )
2015
12
Psychogenic Pain Disorder--Differential Diagnosis and Treatment. ( 26529858 )
2015
13
Hypnotherapy of a pain disorder: a clinical case study. ( 25719524 )
2015
14
Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder. ( 25903274 )
2015
15
What are the treatment options for paroxysmal extreme pain disorder? ( 26059255 )
2015
16
Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study. ( 26129835 )
2015
17
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. ( 24428222 )
2014
18
Self-management is key to fibromyalgia treatment. Treating this common chronic pain disorder has baffled patients and physicians for years. ( 25029737 )
2014
19
Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: a preliminary resting-state fMRI study. ( 24439113 )
2014
20
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. ( 23689753 )
2014
21
Pain as a late emotional reaction. Clinical research evaluating the psychosocial expression of pain disorder in preoperative and postoperative period. ( 25341289 )
2014
22
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. ( 23893323 )
2014
23
Healthcare pathway and biopsychosocial impact of persistent dentoalveolar pain disorder: a qualitative study. ( 24697333 )
2014
24
Facial affect perception and mentalizing abilities in female patients with persistent somatoform pain disorder. ( 24395204 )
2014
25
Restless legs syndrome and pain disorders: what's in common? ( 25249423 )
2014
26
Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. ( 24817410 )
2014
27
Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioral therapy for the treatment and management of chronic pain disorders: protocol for a systematic review and meta-analysis with indirect comparisons. ( 25387478 )
2014
28
p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder. ( 25285947 )
2014
29
Predicting return to work following treatment of chronic pain disorder. ( 23503298 )
2013
30
Effectiveness of a Multimodal Treatment Program for Somatoform Pain Disorder. ( 24305036 )
2013
31
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. ( 24179828 )
2013
32
Neural correlates of deficits in pain-related affective meaning construction in patients with chronic pain disorder. ( 23362496 )
2013
33
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. ( 23909967 )
2013
34
Alexithymic and somatisation scores in patients with temporomandibular pain disorder correlate with deficits in facial emotion recognition. ( 23137311 )
2013
35
Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder. ( 23497482 )
2013
36
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study. ( 22894821 )
2013
37
Insomnia in Chronic Disabling Musculoskeletal Pain Disorders is Independent of Pain and Depression. ( 24333458 )
2013
38
The trade-off between costs and quality of care in the treatment of psychosomatic patients with somatoform pain disorder. ( 23852985 )
2013
39
Paroxysmal extreme pain disorder. ( 23599527 )
2013
40
Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations. ( 21984269 )
2012
41
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. ( 23738195 )
2012
42
The grapes of war. Somatoform pain disorder and history of early war traumatization in older people. ( 22782661 )
2012
43
Interstitial cystitis/bladder pain syndrome: management of the pain disorder: a urogynecology perspective. ( 22877721 )
2012
44
Alcohol dependence as a chronic pain disorder. ( 22975446 )
2012
45
Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents. ( 21115638 )
2011
46
Dysfunctional pain modulation in somatoform pain disorder patients. ( 20924589 )
2011
47
Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. ( 21079636 )
2011
48
The causes and prevalence of vestibulodynia: a vulvar pain disorder. ( 21542444 )
2011
49
Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study. ( 20727111 )
2010
50
Case reports: anesthesia for a patient with paroxysmal extreme pain disorder. ( 20435947 )
2010

Variations for Pain Disorder

Expression for Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for Pain Disorder

Pathways related to Pain Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ATP4A SCN10A SCN11A SCN4B SCN9A
2
Show member pathways
12.36 SCN10A SCN11A SCN4B SCN9A TAC1
3 12.17 ADRB2 NGF SCN10A SCN11A SCN9A
4 11.83 IL1B NGF SCN4B TAC1
5
Show member pathways
11.55 SCN10A SCN11A SCN4B SCN9A
6
Show member pathways
11.13 SCN10A SCN11A SCN4B SCN9A
7 10.96 NGF TRPV1
8 10.83 TRPA1 TRPV1
9 10.4 SCN10A SCN11A SCN4B SCN9A

GO Terms for Pain Disorder

Cellular components related to Pain Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 ADRB2 ATP4A P2RX2 SCN10A SCN11A SCN4B
2 integral component of plasma membrane GO:0005887 9.43 ADRB2 ATP4A P2RX2 SCN9A TRPA1 TRPV1
3 intrinsic component of plasma membrane GO:0031226 9.26 SCN4B TRPV1
4 voltage-gated sodium channel complex GO:0001518 8.92 SCN10A SCN11A SCN4B SCN9A

Biological processes related to Pain Disorder according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.99 SCN10A SCN11A SCN9A TRPA1 TRPV1
2 inflammatory response GO:0006954 9.92 IL1B SCN9A TAC1 TRPV1
3 cell-cell signaling GO:0007267 9.91 ADRB2 IL1B NGF TAC1
4 cell surface receptor signaling pathway GO:0007166 9.88 ADRB2 CABIN1 TRPA1 TRPV1
5 regulation of ion transmembrane transport GO:0034765 9.86 SCN10A SCN11A SCN4B SCN9A
6 ion transmembrane transport GO:0034220 9.85 ATP4A SCN11A SCN9A TRPA1 TRPV1
7 neuronal action potential GO:0019228 9.67 SCN10A SCN11A SCN9A
8 sodium ion transmembrane transport GO:0035725 9.67 SCN10A SCN11A SCN4B SCN9A
9 membrane depolarization during action potential GO:0086010 9.65 SCN10A SCN11A SCN9A
10 response to ATP GO:0033198 9.61 IL1B P2RX2
11 response to carbohydrate GO:0009743 9.6 IL1B P2RX2
12 diet induced thermogenesis GO:0002024 9.58 ADRB2 TRPV1
13 response to pain GO:0048265 9.58 TAC1 TRPA1 TRPV1
14 urinary bladder smooth muscle contraction GO:0014832 9.57 P2RX2 TRPV1
15 regulation of postsynaptic membrane potential GO:0060078 9.56 SCN10A SCN11A SCN4B SCN9A
16 ion transport GO:0006811 9.56 ATP4A P2RX2 SCN10A SCN11A SCN4B SCN9A
17 AV node cell action potential GO:0086016 9.55 SCN10A SCN4B
18 sodium ion transport GO:0006814 9.55 ATP4A SCN10A SCN11A SCN4B SCN9A
19 fever generation GO:0001660 9.54 IL1B TRPV1
20 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.52 TRPA1 TRPV1
21 thermoception GO:0050955 9.51 TRPA1 TRPV1
22 behavioral response to pain GO:0048266 9.5 P2RX2 SCN9A TRPV1
23 sensory perception of pain GO:0019233 9.02 SCN10A SCN9A TAC1 TRPA1 TRPV1
24 transport GO:0006810 10.09 ATP4A LAPTM4A P2RX2 SCN10A SCN11A SCN4B

Molecular functions related to Pain Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.56 SCN10A SCN11A SCN4B SCN9A
2 ion channel activity GO:0005216 9.55 P2RX2 SCN10A SCN11A SCN9A TRPV1
3 calcium-release channel activity GO:0015278 9.32 TRPA1 TRPV1
4 sodium channel activity GO:0005272 9.26 SCN10A SCN11A SCN4B SCN9A
5 voltage-gated sodium channel activity GO:0005248 8.92 SCN10A SCN11A SCN4B SCN9A

Sources for Pain Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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