Aliases & Classifications for Pain Disorder

MalaCards integrated aliases for Pain Disorder:

Name: Pain Disorder 12 52 14 69
Paine Syndrome 50 69
Pain 29 41
Microcephaly with Spastic Diplegia 50

Characteristics:

HPO:

32
pain disorder:
Inheritance x-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0060164
ICD10 33 R52 R52.9

Summaries for Pain Disorder

MedlinePlus : 41 pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen, chest, or pelvis. or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture, and sometimes surgery are helpful.

MalaCards based summary : Pain Disorder, also known as paine syndrome, is related to paroxysmal extreme pain disorder and complex regional pain syndrome, and has symptoms including microcephaly, spastic diplegia and olivopontocerebellar hypoplasia. An important gene associated with Pain Disorder is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Acetaminophen and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and testes, and related phenotypes are integument and nervous system

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia : 72 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Related Diseases for Pain Disorder

Diseases in the Chronic Pain family:

Pain Disorder Central Pain Syndrome

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 paroxysmal extreme pain disorder 34.4 SCN11A SCN9A
2 complex regional pain syndrome 12.2
3 central pain syndrome 12.1
4 patellofemoral pain syndrome 12.1
5 myofascial pain syndrome 12.1
6 episodic pain syndrome, familial, 3 12.0
7 episodic pain syndrome, familial, 2 12.0
8 episodic pain syndrome, familial, 1 11.9
9 familial episodic pain syndrome 11.9
10 neuropathy, hereditary sensory and autonomic, type v 10.7 NGF SCN9A
11 erythromelalgia 10.7
12 hypermobility of coccyx 10.7 NGF TRPV1
13 congenital absence of both lower leg and foot, bilateral 10.7 SCN11A SCN9A
14 marasmus 10.6 NGF TRPV1
15 malignant renovascular hypertension 10.6 NGF TAC1
16 pseudoainhum 10.6 NGF TAC1
17 waardenburg's syndrome 10.6 SCN4B SCN9A
18 brain compression 10.5 NGF TRPV1
19 familial hypertension 10.5 SCN11A TRPA1
20 pancreatic acinar cell adenocarcinoma 10.5 NGF SCN9A TRPV1
21 diffuse large b-cell lymphoma 10.5 NGF SCN9A TRPV1
22 polysyndactyly with cardiac malformation 10.5 ATP4A CABIN1
23 acrocephalopolydactylous dysplasia 10.4 SCN11A SCN9A TRPV1
24 arachnoiditis 10.4
25 focal hand dystonia 10.4 ATP4A TAC1
26 neovascular glaucoma 10.4 NGF TAC1 TRPV1
27 simple chronic conjunctivitis 10.3 BDNF NGF
28 cryptogenic organizing pneumonia 10.3 ATP4A TAC1 TRPV1
29 synostosis 10.3 ATP4A CABIN1 NGF
30 persistent idiopathic facial pain 10.3
31 trigeminal neuralgia 10.3
32 allergic urticaria 10.3 ATP4A TAC1
33 lacrimal apparatus disease 10.2 ATP4A IL1B
34 high pressure neurological syndrome 10.2 IL1B SCN9A TAC1
35 angiomyolipoma 10.2 CABIN1 TAC1
36 scrotal carcinoma 10.2 ATP4A IL1B
37 influenza 10.2 IL1B NGF
38 diversion colitis 10.2 ATP4A IL1B
39 scleral staphyloma 10.2 ATP4A TRPV1
40 endometrial clear cell adenocarcinoma 10.2 IL1B TAC1 TRPV1
41 insensitivity to pain, congenital 10.2 SCN11A SCN4B SCN9A TRPV1
42 febrile seizures, familial, 3b 10.2 NGF SCN11A SCN9A TRPV1
43 hemopericardium 10.2 NGF TAC1
44 fibrosarcomatous osteosarcoma 10.1 ATP4A IL1B TRPV1
45 spinal canal intradural extramedullary neoplasm 10.1 SCN11A SCN9A TAC1 TRPV1
46 late yaws 10.1 BDNF NGF TAC1
47 ileocolitis 10.1 ATP4A IL1B NGF
48 pervasive developmental disorder 10.1 BDNF TAC1 TRPV1
49 tuberculum sellae meningioma 10.1 ATP4A IL1B TRPV1
50 spontaneous ocular nystagmus 10.0 ADRB2 IL1B TAC1 TRPV1

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to Pain Disorder

Symptoms & Phenotypes for Pain Disorder

Human phenotypes related to Pain Disorder:

32
id Description HPO Frequency HPO Source Accession
1 microcephaly 32 HP:0000252
2 spastic diplegia 32 HP:0001264
3 olivopontocerebellar hypoplasia 32 HP:0006955
4 generalized myoclonic seizures 32 HP:0002123

MGI Mouse Phenotypes related to Pain Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.76 BDNF IL1B NGF SCN11A SCN9A TAC1
2 nervous system MP:0003631 9.65 ADRB2 BDNF IL1B LAPTM4A NGF P2RX2
3 taste/olfaction MP:0005394 8.92 BDNF SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Pain Disorder

Drugs for Pain Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1442)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
2
Dinoprostone Approved Phase 4 363-24-6 5280360
3
Fexofenadine Approved Phase 4 83799-24-0 3348
4
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 60142-96-3 3446
5
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
6
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
7
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
8
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
9
Milnacipran Approved Phase 4,Phase 3,Phase 2,Phase 1 92623-85-3 65833
10
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1 50-48-6 2160
11
Cyclobenzaprine Approved Phase 4,Phase 2,Phase 3 303-53-7 2895
12
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-84-3 187
13
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
14
Citalopram Approved Phase 4,Phase 2,Phase 3,Early Phase 1 59729-33-8 2771
15
Reboxetine Approved, Investigational Phase 4,Phase 3,Phase 2 98769-81-4, 71620-89-8 123628 65856
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
17
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
18
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
19
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
20
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 76-42-6 5284603
21 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1
22
Sufentanil Approved, Investigational Phase 4,Phase 2,Phase 3 56030-54-7 41693
23
Flurbiprofen Approved, Investigational Phase 4,Phase 2 5104-49-4 3394
24
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1 84057-95-4 71273 175805
25
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 27203-92-5 33741
26
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-28-2 5757
27
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
28
Prilocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 721-50-6 4906
29
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
30
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
31
Capsaicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 404-86-4 1548943
32
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
33
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
34
Nicorandil Approved Phase 4 65141-46-0 47528
35
Ticagrelor Approved Phase 4,Phase 2,Phase 3,Phase 1 274693-27-5 9871419
36
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
37
Levobupivacaine Approved Phase 4,Phase 3,Phase 2 27262-47-1 92253
38
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
39
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
40
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
41
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1 132875-61-7 60815
42
Galantamine Approved Phase 4 357-70-0 9651
43
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
44
Meperidine Approved Phase 4,Phase 2,Phase 3 57-42-1 4058
45
Nitrous oxide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 10024-97-2 948
46
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
47
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
48
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
49
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2 112809-51-5 3902
50
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 93-14-1 3516

Interventional clinical trials:

(show top 50) (show all 8976)

id Name Status NCT ID Phase Drugs
1 Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome Unknown status NCT01895153 Phase 4
2 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
3 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
4 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
5 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
6 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
7 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
8 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4 Botulinum Toxin
9 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
10 Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
11 RFN for SIJ Disease Study Unknown status NCT01726608 Phase 4
12 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
13 The Effect of Duloxetine on Interoceptive Awareness Unknown status NCT00337012 Phase 4
14 Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Unknown status NCT01536717 Phase 4 Articaine hydrochloride 2% solution;Sodium Chloride
15 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
16 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
17 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
18 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4 pregabalin;placebo
19 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
20 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
21 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
22 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
23 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4 Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy);Cyclic OC (clormadinone acetate plus ethinil-estradiol)
24 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
25 Fractional Laser Assisted Topical Anesthesia Unknown status NCT02548533 Phase 4 AHES;EMLA cream
26 Memantine for Post-Operative Pain Control Unknown status NCT01041313 Phase 4 Memantine;Placebo
27 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
28 Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
29 Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery Unknown status NCT00762099 Phase 4 Pregabalin;Placebo
30 Paracetamol for Cancer Pain Unknown status NCT01313247 Phase 4 paracetamol;placebo tablets
31 Controlled Trial of Deep Brain Stimulation in Early Patients With Parkinson's Disease Unknown status NCT00354133 Phase 4
32 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
33 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
34 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
35 CT Coronary Angiogram Versus Traditional Care in Emergency Department Assessment of Potential ACS Unknown status NCT00933400 Phase 4
36 Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia Unknown status NCT01703130 Phase 4
37 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
38 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
39 Evaluation of Radial Strain for Assessment of Left Ventricular Function in Transesophageal Echocardiography Unknown status NCT01080495 Phase 4
40 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
41 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
42 The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement Unknown status NCT01312415 Phase 4 Levobupivacaine;Intrathecal morphine
43 Preoperative Anxiety and Postoperative Pain in Children Unknown status NCT00643032 Phase 4
44 Female Sexual Function and Back Pain Unknown status NCT01420276 Phase 4
45 Effect of Music Over the Tolerance to Colonoscopy. Unknown status NCT01285284 Phase 4
46 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
47 Effect of Deksmedetomidine and Remifentanil in Extubation Agitation Unknown status NCT02104297 Phase 4 deksmedetomidine;Remifentanil;Saline
48 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
49 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
50 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4

Search NIH Clinical Center for Pain Disorder

Genetic Tests for Pain Disorder

Genetic tests related to Pain Disorder:

id Genetic test Affiliating Genes
1 Pain 29

Anatomical Context for Pain Disorder

MalaCards organs/tissues related to Pain Disorder:

39
Bone, Prostate, Testes, Heart, Brain, Spinal Cord, Kidney

Publications for Pain Disorder

Articles related to Pain Disorder:

(show top 50) (show all 146)
id Title Authors Year
1
Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder. ( 28453543 )
2017
2
Use of the Central Sensitization Inventory (CSI) as a treatment outcome measure for patients with chronic spinal pain disorder in a functional restoration program. ( 28619687 )
2017
3
Decreased prefrontal brain activation during verbal fluency task in patients with somatoform pain disorder: An exploratory multi-channel near-infrared spectroscopy study. ( 28499896 )
2017
4
Clinical study of duloxetine hydrochloride combined with doxazosin for the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome: An observational study. ( 28272220 )
2017
5
The Fear-avoidance Components Scale (FACS): Responsiveness to Functional Restoration Treatment in a Chronic Musculoskeletal Pain Disorder (CMPD) Population. ( 28328697 )
2017
6
Somatoform Pain Disorder Presenting as "Atypical Facial Pain:" A Rare Presentation in a 13-year-old. ( 28852247 )
2017
7
Low Level Laser Therapy Versus Pharmacotherapy in Improving Myofascial Pain Disorder Syndrome. ( 27330698 )
2016
8
Altered Spontaneous Activity in Patients with Persistent Somatoform Pain Disorder Revealed by Regional Homogeneity. ( 26977802 )
2016
9
Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study. ( 27641732 )
2016
10
Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder. ( 27525141 )
2016
11
Psychophysiological decoupling in alexithymic pain disorder patients. ( 26804974 )
2016
12
Parental Protectiveness Mediates the Association between Parent-Perceived Child Self-Efficacy and Health Outcomes in Pediatric Functional Abdominal Pain Disorder. ( 27657151 )
2016
13
Alexithymia in Chronic Pain Disorders. ( 27215759 )
2016
14
Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder. ( 25903274 )
2015
15
Prevalence of restless legs syndrome in somatoform pain disorder and its effect on quality of life. ( 25883472 )
2015
16
What are the treatment options for paroxysmal extreme pain disorder? ( 26059255 )
2015
17
Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study. ( 26129835 )
2015
18
Effects of Kamishoyosan, a Traditional Japanese Kampo Medicine, on Pain Conditions in Patients with Intractable Persistent Dentoalveolar Pain Disorder. ( 26495024 )
2015
19
Bilateral congenital corneal anesthesia in a patient with SCN9A mutation, confirmed primary erythromelalgia, and paroxysmal extreme pain disorder. ( 26486037 )
2015
20
Hypnotherapy of a pain disorder: a clinical case study. ( 25719524 )
2015
21
Psychogenic Pain Disorder--Differential Diagnosis and Treatment. ( 26529858 )
2015
22
Amplified Brain Processing of Dentoalveolar Pressure Stimulus in Persistent Dentoalveolar Pain Disorder Patients. ( 26485382 )
2015
23
Facial affect perception and mentalizing abilities in female patients with persistent somatoform pain disorder. ( 24395204 )
2014
24
p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder. ( 25285947 )
2014
25
Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. ( 24817410 )
2014
26
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. ( 24428222 )
2014
27
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. ( 23689753 )
2014
28
Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: a preliminary resting-state fMRI study. ( 24439113 )
2014
29
Pain as a late emotional reaction. Clinical research evaluating the psychosocial expression of pain disorder in preoperative and postoperative period. ( 25341289 )
2014
30
Comparative evaluation of group-based mindfulness-based stress reduction and cognitive behavioral therapy for the treatment and management of chronic pain disorders: protocol for a systematic review and meta-analysis with indirect comparisons. ( 25387478 )
2014
31
Healthcare pathway and biopsychosocial impact of persistent dentoalveolar pain disorder: a qualitative study. ( 24697333 )
2014
32
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. ( 23893323 )
2014
33
Restless legs syndrome and pain disorders: what's in common? ( 25249423 )
2014
34
Self-management is key to fibromyalgia treatment. Treating this common chronic pain disorder has baffled patients and physicians for years. ( 25029737 )
2014
35
Alexithymic and somatisation scores in patients with temporomandibular pain disorder correlate with deficits in facial emotion recognition. ( 23137311 )
2013
36
Predicting return to work following treatment of chronic pain disorder. ( 23503298 )
2013
37
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. ( 24179828 )
2013
38
Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder. ( 23497482 )
2013
39
Insomnia in Chronic Disabling Musculoskeletal Pain Disorders is Independent of Pain and Depression. ( 24333458 )
2013
40
Effectiveness of a Multimodal Treatment Program for Somatoform Pain Disorder. ( 24305036 )
2013
41
The trade-off between costs and quality of care in the treatment of psychosomatic patients with somatoform pain disorder. ( 23852985 )
2013
42
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study. ( 22894821 )
2013
43
Neural correlates of deficits in pain-related affective meaning construction in patients with chronic pain disorder. ( 23362496 )
2013
44
Paroxysmal extreme pain disorder. ( 23599527 )
2013
45
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. ( 23909967 )
2013
46
Interstitial cystitis/bladder pain syndrome: management of the pain disorder: a urogynecology perspective. ( 22877721 )
2012
47
The grapes of war. Somatoform pain disorder and history of early war traumatization in older people. ( 22782661 )
2012
48
Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations. ( 21984269 )
2012
49
Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis. ( 23738195 )
2012
50
Alcohol dependence as a chronic pain disorder. ( 22975446 )
2012

Variations for Pain Disorder

Expression for Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for Pain Disorder

GO Terms for Pain Disorder

Cellular components related to Pain Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 ADRB2 ATP4A P2RX2 SCN9A TRPA1 TRPV1
2 intrinsic component of plasma membrane GO:0031226 9.16 SCN4B TRPV1
3 voltage-gated sodium channel complex GO:0001518 8.8 SCN11A SCN4B SCN9A

Biological processes related to Pain Disorder according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 IL1B SCN9A TAC1 TRPV1
2 cell surface receptor signaling pathway GO:0007166 9.85 ADRB2 CABIN1 TRPA1 TRPV1
3 regulation of ion transmembrane transport GO:0034765 9.77 SCN11A SCN4B SCN9A
4 cell-cell signaling GO:0007267 9.77 ADRB2 BDNF IL1B NGF TAC1
5 sodium ion transmembrane transport GO:0035725 9.73 SCN11A SCN4B SCN9A
6 ion transmembrane transport GO:0034220 9.72 ATP4A SCN11A SCN9A TRPA1 TRPV1
7 sodium ion transport GO:0006814 9.71 ATP4A SCN11A SCN4B SCN9A
8 ion transport GO:0006811 9.7 ATP4A P2RX2 SCN11A SCN4B SCN9A TRPA1
9 regulation of postsynaptic membrane potential GO:0060078 9.65 SCN11A SCN4B SCN9A
10 neuronal action potential GO:0019228 9.61 SCN11A SCN9A
11 membrane depolarization during action potential GO:0086010 9.6 SCN11A SCN9A
12 response to ATP GO:0033198 9.58 IL1B P2RX2
13 response to carbohydrate GO:0009743 9.57 IL1B P2RX2
14 diet induced thermogenesis GO:0002024 9.54 ADRB2 TRPV1
15 urinary bladder smooth muscle contraction GO:0014832 9.51 P2RX2 TRPV1
16 fever generation GO:0001660 9.49 IL1B TRPV1
17 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.46 TRPA1 TRPV1
18 thermoception GO:0050955 9.43 TRPA1 TRPV1
19 response to pain GO:0048265 9.43 TAC1 TRPA1 TRPV1
20 behavioral response to pain GO:0048266 9.13 P2RX2 SCN9A TRPV1
21 sensory perception of pain GO:0019233 8.92 SCN9A TAC1 TRPA1 TRPV1
22 transport GO:0006810 10.13 ATP4A LAPTM4A P2RX2 SCN11A SCN4B SCN9A

Molecular functions related to Pain Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.5 SCN11A SCN4B SCN9A
2 ion channel activity GO:0005216 9.46 P2RX2 SCN11A SCN9A TRPV1
3 calcium-release channel activity GO:0015278 9.26 TRPA1 TRPV1
4 sodium channel activity GO:0005272 9.13 SCN11A SCN4B SCN9A
5 voltage-gated sodium channel activity GO:0005248 8.8 SCN11A SCN4B SCN9A

Sources for Pain Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
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