PAIN
MCID: PND001
MIFTS: 49

Pain Disorder (PAIN) malady

Summaries for Pain Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Pain is a feeling triggered in the nervous system. pain may be sharp or dull. it may come and go, or it may be constant. you may feel pain in one area of your body, such as your back, abdomen or chest or you may feel pain all over, such as when your muscles ache from the flu. pain can be helpful in diagnosing a problem. without pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. once you take care of the problem, pain usually goes away. however, sometimes pain goes on for weeks, months or even years. this is called chronic pain. sometimes chronic pain is due to an ongoing cause, such as cancer or arthritis. sometimes the cause is unknown. fortunately, there are many ways to treat pain. treatment varies depending on the cause of pain. pain relievers, acupuncture and sometimes surgery are helpful.

MalaCards: Pain Disorder, also known as PAIN, is related to complex regional pain syndrome and neuropathy. An important gene associated with Pain Disorder is SCN9A (sodium channel, voltage-gated, type IX, alpha subunit), and among its related pathways are Interaction between L1 and Ankyrins and Sodium channels and transporters: inward current. The compounds Lacosamide and aft-ii have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related mouse phenotypes are integument and behavior/neurological.

Disease Ontology:8 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Wikipedia:63 Pain disorder is chronic pain experienced by a patient in one or more areas, and is thought to be caused... more...

Aliases & Classifications for Pain Disorder

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 25ICD10
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Related Diseases for Pain Disorder

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17GeneCards, 18GeneDecks
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Diseases in the Pain Disorder family:

Chronic Pain

Diseases related to Pain Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1765)
idRelated DiseaseScoreTop Affiliating Genes
1complex regional pain syndrome31.5TAC1
2neuropathy31.2SCN8A, SCN9A, NGF, TAC1
3migraine30.6PNOC, TAC1
4constipation30.4TAC1
5ischemia30.1GAL, PNOC, ADRB2
6erythromelalgia30.1SCN3A, SCN8A, SCN9A
7diabetes mellitus30.1TAC1, NGF, CABIN1
8fibromyalgia30.0PNOC, TAC1
9pain agnosia29.9PNOC, TAC1
10dermatitis29.8TAC1
11ganglioneuroma29.7NGF, GAL
12cystitis29.6TAC1, NGF
13long qt syndrome29.6SCN3A, SCN4B, SCN8A
14respiratory failure29.5ADRB2, TAC1
15type 2 diabetes mellitus29.5ADRB2, NGF, GAL
16parkinson's disease29.5ADRB2, TAC1, NGF, GAL
17atopic dermatitis29.3NGF, CABIN1
18brugada syndrome29.3SCN8A, SCN4B
19cholera29.3ADRB2, TAC1, NGF, GAL
20malignant glioma29.3GAL, NGF, TAC1, PNOC, ADRB2
21patellofemoral pain syndrome10.8
22myofascial pain syndrome10.7
23prostatitis10.7
24diabetic neuropathy10.7
25osteoarthritis10.6
26cervicitis10.6
27somatoform disorder10.6
28anhidrosis10.6
29peripheral neuropathy10.5
30arthritis10.5
31reflex sympathetic dystrophy10.5
32radiculopathy10.5
33pancreatitis10.5
34polyneuropathy10.5
35endometriosis10.4
36trigeminal neuralgia10.4
37neuroma10.4
38ophthalmoplegia10.4
39causalgia10.4
40herpes zoster10.4
41fasciitis10.4
42spinal stenosis10.4
43sickle cell disease10.4
44plantar fasciitis10.4
45rheumatoid arthritis10.4
46paroxysmal extreme pain disorder10.4
47chronic pain10.4
48diabetic polyneuropathy10.4
49bursitis10.4
50chronic interstitial cystitis10.3

Graphical network of the top 20 diseases related to Pain Disorder:



Diseases related to pain disorder

Clinical Features for Pain Disorder

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Drugs & Therapeutics for Pain Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pain Disorder

Search CenterWatch for Pain Disorder

Genetic Tests for Pain Disorder

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Anatomical Context for Pain Disorder

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32MalaCards
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MalaCards organs/tissues related to Pain Disorder:

32
Bone, Testes, Spinal cord, Prostate, Brain, Breast, Pituitary

Animal Models for Pain Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pain Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0PNOC, TAC1, NGF, GAL, SCN9A
2MP:00053866.6ADRB2, SCN3A, SCN8A, SCN9A, GAL, NGF

Publications for Pain Disorder

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Sources:
50PubMed
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Articles related to Pain Disorder:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Differential brain activity in subjects with painful trigeminal neuropathy and painful temporomandibular disorder. (24269492)
2013
2
Predicting return to work following treatment of chronic pain disorder. (23503298)
2013
3
Borderline personality disorder and chronic pain: a practical approach to evaluation and treatment. (23801003)
2013
4
Management of chronic pain with chronic opioid therapy in patients with substance use disorders. (24341916)
2013
5
Anhedonia and Pain Avoidance in the Suicidal Mind: Behavioral Evidence for Motivational Manifestations of Suicidal Ideation in Patients With Major Depressive Disorder. (24307489)
2013
6
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. (23909967)
2013
7
Somatosensory Processing and Borderline Personality Disorder: Pain Perception and a Signal Detection Analysis of Proprioception and Exteroceptive Sensitivity. (23834516)
2013
8
The reliability of measuring pain distribution and location using body pain diagrams in patients with acute whiplash-associated disorders. (23891480)
2013
9
Specific Pain Complaints in Iraq and Afghanistan Veterans Screening Positive for Post-Traumatic Stress Disorder. (23473449)
2013
10
A brief cognitive-behavioral intervention for treating depression and panic disorder in patients with noncardiac chest pain: a 24-week randomized controlled trial. (23625592)
2013
11
Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a cross-sectional study. (21510887)
2011
12
Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents. (21115638)
2011
13
Whiplash-associated disorder: musculoskeletal pain and related clinical findings. (23115472)
2011
14
Altered postural sway in patients suffering from non-specific neck pain and whiplash associated disorder - A systematic review of the literature. (21609469)
2011
15
Sympathetic nervous system disorder of women that leads to pelvic pain and symptoms of interstitial cystitis may be the cause of severe backache and be very responsive to medical therapy rather than surgery despite the presence of herniated discs. (21793284)
2011
16
Case reports: anesthesia for a patient with paroxysmal extreme pain disorder. (20435947)
2010
17
Is surface EMG biofeedback an effective training method for persons with neck and shoulder complaints after whiplash-associated disorders concerning activities of daily living and pain -- a randomized controlled trial. (20562165)
2010
18
Movement disorders in complex regional pain syndrome. (20704676)
2010
19
Increased cannabinoid receptor 1-immunoreactive nerve fibers in overactive and painful bladder disorders and their correlation with symptoms. (20346490)
2010
20
What is the evidence for chronic pain being etiologically associated with the DSM-IV category of sleep disorder due to a general medical condition? A structured evidence-based review. (19788712)
2010
21
Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders. (20429905)
2010
22
Movement disorders associated with complex regional pain syndrome in children. (19018846)
2009
23
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. (19733606)
2009
24
A model for self-treatment of four sub-types of symptomatic 'depression' using non-prescription agents: neuroticism (anxiety and emotional instability); malaise (fatigue and painful symptoms); demotivation (anhedonia) and seasonal affective disorder 'SAD'. (18848402)
2009
25
The cost of comorbid depression and pain for individuals diagnosed with generalized anxiety disorder. (19214050)
2009
26
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. (18803825)
2008
27
Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and whiplash-associated disorders (WAD)? A randomized controlled trial. (18608312)
2008
28
The relationship between functional outcomes and the treatment of anxious and painful somatic symptoms in patients with generalized anxiety disorder. (18662492)
2008
29
Mechanisms of pain referral in patients with whiplash-associated disorder. (18068382)
2008
30
NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders. (18945915)
2008
31
Cerebral activation in patients with somatoform pain disorder exposed to pain and stress: an fMRI study. (17428684)
2007
32
Paroxysmal extreme pain disorder (previously familial rectal pain syndrome). (17679678)
2007
33
Factors influencing neck pain intensity in whiplash-associated disorders in Sweden. (17710009)
2007
34
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. (17145499)
2006
35
Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. (16741943)
2006
36
Dyspareunia: a pain disorder or sexual dysfunction? (16092026)
2005
37
Facial expression and experience of emotions in psychodynamic interviews with patients suffering from a pain disorder. Indicators of disorders in self- and relationship regulation in the involuntaryfacial expression of emotions. (15539777)
2004
38
The association between wear facets, bruxism, and severity of facial pain in patients with temporomandibular disorders. (12886214)
2003
39
Sleep disturbances in somatoform pain disorder. (14707439)
2003
40
Determinants of health-related quality of life in patients with persistent somatoform pain disorder. (12935799)
2003
41
Pharmacologic interventions in the treatment of temporomandibular disorders, atypical facial pain, and burning mouth syndrome. A qualitative systematic review. (14737874)
2003
42
Interactions of a history of migration with the course of pain disorder. (11399284)
2001
43
A case of pain, factitious disorder and boundary violations. (11854765)
2001
44
Mitral valve prolapse versus panic disorder in patients with chest pain. (10847792)
2000
45
Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain. (9625218)
1998
46
"Doctor, I'm in pain, but please don't hurt me." Somatization disorder: diagnosis and treatment. (8436567)
1993
47
The bidirectional dose-dependent effect of systemic naloxone is also related to the intensity and duration of pain-related disorders: a study in a rat model of peripheral mononeuropathy. (2173962)
1990
48
Chronic pain masks depression, multiple personality disorder. (3679099)
1987
49
Somatization disorder in relatives of children and adolescents with functional abdominal pain. (6520659)
1984
50
Cervical spondylosis presenting as the facial pain of temporomandibular joint disorder. (5658372)
1968

Genetic Variations for Pain Disorder

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Expression for genes affiliated with Pain Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pain Disorder

Search GEO for disease gene expression data for Pain Disorder.

Pathways for genes affiliated with Pain Disorder

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Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Pain Disorder

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Sources:
11DrugBank, 28IUPHAR, 44Novoseek, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Pain Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Lacosamide1110.2SCN9A, SCN3A
2aft-ii2810.1SCN3A, SCN8A
3bc-iii2810.1SCN3A, SCN8A
4atx-ii2810.1SCN3A, SCN8A
5clenbuterol44 1110.9ADRB2, NGF
6saxitoxin289.9SCN3A, SCN8A, SCN9A
7batrachotoxin289.9SCN9A, SCN8A, SCN3A
8gnrh449.9ADRB2, GAL
9octadecaneuropeptide449.8PNOC, GAL
10zonisamide44 1110.7SCN9A, SCN4B, SCN3A
11helospectin449.7TAC1, GAL
12naloxone44 49 28 1112.6ADRB2, PNOC, GAL
13phenoxybenzamine44 1110.5TAC1, ADRB2
14fenoterol44 28 1111.5ADRB2, TAC1
15tetrodotoxin citrate599.4SCN3A, SCN4B, SCN8A, SCN9A
16qx 314 chloride599.4SCN9A, SCN8A, SCN4B, SCN3A
17phrixotoxin 3599.4SCN3A, SCN4B, SCN8A, SCN9A
18veratridine44 59 2811.4SCN3A, SCN4B, SCN8A, SCN9A
19guanethidine44 1110.3PNOC, TAC1
20ltd4449.3TAC1, GAL
21theophylline44 28 11 2412.2ADRB2, TAC1, NGF
22propranolol44 28 49 11 2413.2NGF, TAC1, ADRB2
23cocaine44 1110.2GAL, NGF, PNOC, ADRB2
24levodopa44 1110.2TAC1, NGF, GAL
25amphetamine44 1110.1PNOC, TAC1, GAL
26baclofen44 1110.0PNOC, TAC1
27carbachol44 28 1111.0ADRB2, TAC1, NGF, GAL
28epinephrine44 11 2410.9GAL, NGF, TAC1, ADRB2
29opiate448.8ADRB2, PNOC, TAC1, GAL
30phosphoinositide448.8GAL, NGF, TAC1, ADRB2
315-hydroxytryptamine448.8GAL, TAC1, PNOC, ADRB2
32gaba448.8GAL, TAC1, PNOC, ADRB2
33capsaicin44 289.7GAL, NGF, TAC1, PNOC
34atropine44 28 1110.7GAL, NGF, TAC1, PNOC
35pge2448.5ADRB2, PNOC, TAC1, GAL
36potassium44 11 2410.4SCN8A, GAL, TAC1, PNOC, ADRB2
37morphine44 49 28 1111.4ADRB2, PNOC, TAC1, NGF, GAL
38norepinephrine44 11 2410.4GAL, NGF, TAC1, PNOC, ADRB2
39histamine44 28 2410.4GAL, NGF, TAC1, PNOC, ADRB2
40acetylcholine44 49 28 11 2412.4ADRB2, PNOC, TAC1, NGF, GAL
41forskolin44 49 1110.4ADRB2, PNOC, TAC1, NGF, GAL
42dopamine44 28 11 2411.3GAL, NGF, TAC1, PNOC, ADRB2
43adenylate448.3GAL, NGF, TAC1, PNOC, ADRB2
44nitric oxide44 11 2410.3CABIN1, GAL, TAC1, PNOC, ADRB2
45cyclic amp44 249.3GAL, NGF, TAC1, PNOC, ADRB2
46testosterone44 59 11 2411.3GAL, NGF, TAC1, ADRB2
47tetrodotoxin44 59 2810.2TAC1, GAL, SCN9A, SCN8A, SCN4B, SCN3A
48glutamate448.2GAL, NGF, TAC1, PNOC, ADRB2
49estrogen448.0GAL, TAC1, GPER1, PNOC, ADRB2
50sodium44 248.6SCN3A, SCN4B, SCN8A, SCN9A, GAL, TAC1

GO Terms for genes affiliated with Pain Disorder

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16Gene Ontology
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Cellular components related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015188.9SCN9A, SCN8A, SCN4B, SCN3A

Biological processes related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of action potential in neuronGO:0192289.6GPER1, SCN9A
2peripheral nervous system developmentGO:0074229.3NGF, SCN8A
3positive regulation of apoptotic processGO:0430659.2GPER1, NGF, GAL
4sodium ion transportGO:0068149.0SCN9A, SCN8A, SCN4B, SCN3A
5neuropeptide signaling pathwayGO:0072188.7GAL, TAC1, PNOC
6inflammatory responseGO:0069548.7TAC1, NGF, GAL, SCN9A

Molecular functions related to Pain Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6PNOC, GAL
2voltage-gated sodium channel activityGO:0052488.6SCN9A, SCN8A, SCN4B, SCN3A

Products for genes affiliated with Pain Disorder

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Sources for Pain Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet