Paine Syndrome malady

MalaCards: Paine Syndrome, also known as microcephaly with spastic diplegia, is related to complex regional pain syndrome and myofascial pain syndrome. An important gene associated with Paine Syndrome is MSD (microcephaly with spastic diplegia (Paine syndrome)), and among its related pathways are Pathogenesis of ALS and Activation of NMDA receptor upon glutamate binding and postsynaptic events. The compounds sb 203580 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and prostate, and related mouse phenotypes are respiratory system and liver/biliary system.

paine syndrome 30 43 microcephaly with spastic diplegia 30

Diseases related to paine syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 835)

id	Related Disease	Score	Top Affiliating Genes
1	complex regional pain syndrome	32.9	SGCE, GCH1, LPO, LIN9, SCN9A, CD14
2	myofascial pain syndrome	30.5	KCNK2, LAPTM4A, SPAG1, NDUFB8, TAC1, PSTPIP1
3	patellofemoral pain syndrome	30.3	ZC3H12D, SCGB1D1, YES1, LARS, MSLNL, ANXA13
4	cystitis	28.8	CHI3L1, IL1A, IL6, IL8, CAV1, TNF
5	chronic pain	27.2	LEP, GRIN2B, IL10, IL6, CALCA, NR3C1
6	dyspepsia	27.1	CD14, IL1B, IL8, GPC3, GNB3, CALCA
7	urethritis	26.1	IL8, CALCA, HLA-B, TNF, DRD2, KLK3
8	adult-onset still's disease	25.9	CDKN3, FCGR3A, IL1B, IL6, IL8, CCL2
9	headache	25.9	IL1B, IL2, IL6, CCL2, IFNG, GNB3
10	fibromyalgia	25.5	CHKB, LAPTM4A, GRIN2D, IL10, IL1B, IL2
11	chronic fatigue syndrome	24.9	IL10, IL2, IL6, IFNG, HLA-DQB1, HLA-DRB1
12	acute lymphoblastic leukemia	21.5	LEP, CHKB, CDKN3, MME, IL10, IL1B
13	lymphoblastic leukemia	21.4	LEP, CHKB, CDKN3, MME, IL10, IL1B
14	prostatitis	21.1	SGCE, LPO, SCGB1D1, SCN9A, LEP, CHI3L1
15	leukemia	15.3	SGCE, LPO, ZC3H12D, LEP, CHKA, CHKB
16	chronic eosinophilic pneumonia	13.9	IL10, CXCL9, CXCR3
17	cryptosporidiosis	13.9	IL1A, MBL2, CCL5, TAC1
18	vasomotor rhinitis	13.9	IL10, CALCA, TAC1
19	chorea	13.8	SGCE, GFAP, CXCL9, NPY, ADRB2
20	sepsis	13.8	CD14, IL10, TNF
21	fissured tongue	13.8	IL1B, IL6, TNF
22	melioidosis	13.8	IL10, IL1B, IL6, CXCL9, CXCR3
23	social phobia	13.8	DRD2, TACR1, SOD1, NPY
24	intermediate uveitis	13.8	IL10, IFNG, TNF, CXCR3
25	somatoform disorder	13.8	GCH1, IL1A, IL1B, TRPA1
26	contact dermatitis	13.8	IL1A, CXCL9, CXCR3
27	relapsing-remitting multiple sclerosis	13.8	IL10, CCL5, IFNG, CXCR3
28	autonomic dysfunction	13.8	SCN9A, MME, IL6, HCRT, NPY
29	myoclonus-dystonia	13.8	SGCE, GCH1, DRD2
30	normal pressure hydrocephalus	13.8	ACE, GFAP, TGFB1, NPY
31	septic arthritis	13.8	IL1B, ANKLE2, IFNG, TNF, CXCR3
32	psoriatic arthritis	13.8	IL10, IL1B, IL6, TNF
33	radiculopathy	13.8	IL1A, IL6, CXCL9, CXCR3
34	hypoaldosteronism	13.8	IL6, ACE, POMC
35	mycobacterium avium complex disease	13.8	IL10, IL6, IFNG, TNF
36	obstructive lung disease	13.8	CALCA, TNF, ACE, TGFB1, ADRB2
37	hepatorenal syndrome	13.8	TNF, EDN1, ACE, NPY
38	vulvar vestibulitis syndrome	13.7	IL1B, MBL2, TNF
39	hirschsprung's disease	13.7	MME, CALCA, EDN1, GFAP, TAC1, NPY
40	listeriosis	13.7	IL6, MBL2, IFNG, TNF
41	eales disease	13.7	IL6, IFNG, TNF, SOD1
42	phobia	13.7	DRD2, TACR1, SOD1, NPY
43	acrodermatitis	13.7	IL1B, IFNG, TNF, CXCL9
44	myoclonus	13.7	SGCE, GCH1, CDKN3, DRD2, GFAP, POMC
45	retinal artery occlusion	13.7	IL10, IL6, TNF, ACE
46	african tick-bite fever	13.7	IL10, CCL3, CCL5, IFNG
47	bone cancer	13.7	IL1B, CALCA, ACPP, GFAP, TACR1
48	systolic heart failure	13.7	IL6, TNF, EDN1, ACE
49	neuroendocrine tumor	13.7	CALCA, DRD2, TAC1, POMC, NPY
50	paratyphoid fever	13.7	IL1A, IL1B, IFNG, TNF, TNFRSF1A

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to paine syndrome:

²²

MGI Mouse Phenotypes related to paine syndrome:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	CD14, TRPA1, HCRT, DRD2, CALCA, MB
2	liver/biliary system phenotype	MP:0005370	9.8	SOD1, CHKA, IL2, IL6, IFNG, DRD2
3	endocrine/exocrine gland phenotype	MP:0005379	9.4	CAV1, IL2, LIN9, IFNG
4	skeleton phenotype	MP:0005390	9.4	GPC3, NR3C1, TACR1, TNFRSF1A, LEP, CAV1
5	renal/urinary system phenotype	MP:0005367	9.3	ADRA1A, YES1, GPC3, CAV1, DRD2, TAC1
6	integument phenotype	MP:0010771	8.9	IFNG, GRIN2A, MME, YES1, TRPA1, POMC
7	hematopoietic system phenotype	MP:0005397	8.9	MB, GPC3, SOD2, YES1, HLA-DQB1
8	digestive/alimentary phenotype	MP:0005381	8.5	CCL2, CCL3, LIN9, GPC3, LEP, NR3C1
9	growth/size phenotype	MP:0005378	8.3	MB, GFAP, GABPA, SLC6A6, NPY, HCRT
10	vision/eye phenotype	MP:0005391	8.1	TGFB1, GFAP, NGF, TNFRSF1A, TNF, IFNG
11	reproductive system phenotype	MP:0005389	7.9	LEP, IL6, CCL2, IFNG, CAV1, TNF
12	adipose tissue phenotype	MP:0005375	7.9	TNF, IL6, CCL2, TNFRSF1A, DRD2, CD14
13	tumorigenesis	MP:0002006	7.8	IL10, PRF1, CXCR3, SOD2, POMC, CCL2
14	nervous system phenotype	MP:0003631	7.5	HCRT, LIN9, HSPA1A, CCL3, GRIN3B, GRIN2D
15	muscle phenotype	MP:0005369	7.2	MB, IL10, CHKB, SGCE, TNF, IL6
16	immune system phenotype	MP:0005387	7.2	IFNG, GPC3, CCL3, MBL2, IL6, IL2
17	mortality/aging	MP:0010768	6.7	TNFRSF1A, IL6, CAV1, IFNG, CCL3, CCL2
18	cardiovascular system phenotype	MP:0005385	6.1	GPC3, MB, HCRT, GFAP, TGFB1, TACR1
19	behavior/neurological phenotype	MP:0005386	5.8	NGF, ADRB2, ACE, ACPP, HCRT, GFAP
20	homeostasis/metabolism phenotype	MP:0005376	5.7	ADRA1A, ADRB2, SLC6A6, NPY, POMC, SOD2
21	cellular phenotype	MP:0005384	5.7	CCL3, HSPA1A, GABPA, CAV1, HLA-DQB1, TNF

Articles related to paine syndrome:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Elevated blood levels of inflammatory monocytes (CD14 + CD16+ ) in patients with complex regional pain syndrome. (21303362)	Ritz B.W.... Schwartzman R.J.	2011	CD14, FCGR3A, IL10
2	Caveolin-1 may participate in the pathogenesis of bla dder pain syndrome/ interstitial cystitis. (21335944)	Lin X.C.... Lu G.S.	2011	CAV1
3	A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. (20547126)	Kremeyer B.... Ruiz-Linares A.	2010	TRPA1
4	Pathophysiology of fibromyalgia: a comparison with th e tension-type headache, a localized pain syndrome. (20398011)	Iannuccelli C.... Valesini G.	2010	NPY
5	Characterization of circulating CD4+CD25high regulato ry T cells in men with chronic prostatitis/chronic pelvic pain syndrome. (19800664)	Bai J.... Su S.	2010	TNF, IL6, IL10
6	No mutations in the voltage-gated NaV1.7 sodium chann el alpha1 subunit gene SCN9A in familial complex regional pain syndrome. (20074229)	de Rooij A.M.... van den Maagdenberg A.M.	2010	SCN9A
7	Frequencies of polymorphisms in cytokines, neurotrans mitters and adrenergic receptors in patients with complex regional pain syndrom e type I after distal radial fracture. (20173430)	Herlyn P.... Gradl G.	2010	TGFB1, TNF, IL6
8	Systematic mutation analysis of seven dystonia genes in complex regional pain syndrome with fixed dystonia. (20066431)	Gosso M.F.... van den Maagdenberg A.M.	2010	SGCE
9	Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS). (20105452)	Huehne K.... Winterpacht A.	2010	MME, CALCA
10	MicroRNAs may mediate the down-regulation of neurokin in-1 receptor in chronic bladder pain syndrome. (20008142)	Sanchez Freire V.... Monastyrskaya K.	2010	TACR1
11	The role of genomic oxidative-reductive balance as pr edictor of complex regional pain syndrome development: a novel theory. (20119466)	Smith H.S.	2010	GCH1, DRD2, GABPA
12	The first scintigraphic detection of tumor necrosis f actor-alpha in patients with complex regional pain syndrome type 1. (19910617)	Bernateck M.... Brunkhorst T.	2010	TNF
13	YKL-40 and mast cells are associated with detrusor fi brosis in patients diagnosed with bladder pain syndrome/interstitial cystitis a ccording to the 2008 criteria of the European Society for the Study of Intersti tial Cystitis. (20840668)	Richter B.... Hansen A.B.	2010	CHI3L1
14	The G-protein beta3 subunit 825 TT genotype is associ ated with epigastric pain syndrome-like dyspepsia. (20102604)	Oshima T.... Miwa H.	2010	GNB3
15	Urinary nerve growth factor level is increased in pat ients with interstitial cystitis/bladder pain syndrome and decreased in respond ers to treatment. (19522864)	Liu H.T.... Kuo H.C.	2009	NGF
16	A unifying theory linking the prolonged efficacy of t he stellate ganglion block for the treatment of chronic regional pain syndrome (CRPS), hot flashes, and posttraumatic stress disorder (PTSD). (19237252)	Lipov E.G.... Slavin K.V.	2009	NGF
17	T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome. (19765754)	Kouiavskaia D.V.... Alexander R.B.	2009	ACPP, KLK3
18	Serum and salivary oxidative analysis in Complex Regional Pain Syndrome. (18539395)	Eisenberg E.... Nagler R.M.	2008	SOD1, LPO
19	Calcineurin-inhibitor induced pain syndrome (CIPS) in an adult-onset Still's disease patient (19069122)	Maeshima K.... Yoshimatsu H.	2008	CABIN1
20	Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome. (18353390)	Desireddi N.V.... Schaeffer A.J.	2008	CCL2, CCL3
21	Pharmacotherapy options for complex regional pain syndrome. (17492902)	Eisenberg E.... Brill S.	2007	CALCA
22	Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. (16905241)	Penna G.... Adorini L.	2007	IL6, IL1B, IL8
23	Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome. (17129705)	Alexander G.M.... Schwartzman R.J.	2007	IL6, GFAP, IL10
24	Calcineurin-inhibitor induced pain syndrome after organ transplantation. (16955101)	Collini A.... Carmellini M.	2006	CABIN1
25	Prolonged fasting in patients with chronic pain syndromes leads to late mood-enhancement not related to weight loss and fasting-induced leptin depletion. (17263085)	Michalsen A.... Dobos G.J.	2006	LEP
26	Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. (17137491)	Groeneweg J.G.... Zijlstra F.J.	2006	EDN1
27	Pathophysiology of complex regional pain syndrome. (16734515)	Schwartzman R.J.... Grothusen J.	2006	CDKN3
28	Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. (16864900)	Heijmans-Antonissen C.... Zijlstra F.J.	2006	CXCR3, CXCL9
29	Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome. (16514322)	Schinkel C.... Schuermann M.	2006	NPY
30	Acute lymphoblastic leukemia presenting with calcineurin-inhibitor induced pain syndrome after a second allogeneic bone marrow transplantation (17094576)	Takashima S.... Harada M.	2006	CABIN1
31	Manganese superoxide dismutase polymorphism in chronic pelvic pain syndrome patients. (16847469)	Arisan E.D.... Ergenekon E.	2006	SOD2
32	Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. (16442595)	Nadler R.B.... Alexander R.B.	2006	KLK3
33	Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy. (15980934)	Sahin F.... Kuran B.	2006	CALCA
34	Erythromelalgia: a hereditary pain syndrome enters the molecular era. (15929046)	Waxman S.G.... Dib-Hajj S.D.	2005	SCN9A
35	What is the place of diphosphonates in the treatment of complex regional pain syndrome I? (15833263)	Chauvineau V.... PAclissier J.	2005	CALCA
36	Effect of inflammatory chronic pelvic pain syndrome on the levels of prostatic specific antigen (15638019)	Hu Y.... Huang Y.	2004	KLK3
37	Drug therapy in complex regional pain syndrome type I (15150686)	Von Eisenhart-Rothe R.... Rittmeister M.	2004	CALCA
38	Calcineurin-inhibitor pain syndrome following haematopoietic stem cell transplantation. (15257699)	Kida A.... Sakamaki H.	2004	CABIN1
39	Differential Diagnosis Macro CK Type 1 in Thoracic Pain Syndrome and Increased CK-MB (14586513)	Strobel E.S.... Schmolke B.	2003	CSNK1A1, CHKA
40	A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II. (12855316)	Kingery W.S.... Clark J.D.	2003	TACR1
41	Increased production of nitric oxide stimulated by interferon-gamma from peripheral blood monocytes in patients with complex regional pain syndrome. (11911993)	Hartrick C.T.	2002	IL1B, IFNG
42	Complex regional pain syndrome after thromboendarterectomy: which type is it? (12192276)	Baillet G.... Foult J.M.	2002	CALCA
43	Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome. (11927336)	Miller L.J.... Kreutzer D.L.	2002	NGF
44	Experiences with calcitonin treatment of patients with type I complex regional pain syndrome (CRPS I--Sudeck disease) (11605299)	SchA1rmann M.... Gradl G.	2001	CALCA
45	Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. (11263551)	Grotz W.H.... Schollmeyer P.J.	2001	CABIN1
46	Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. (10751014)	Buskila D.	2000	POMC
47	Pathogenetic basis for the use of GABA-ergic prepara tions in combination with atropine during chronic pain syndrome in patients wit h neurologic manifestations of lumbar osteochondrosis (10802884)	Nechipurenko N.I.... Elkin I.u.B.	2000	NR3C1
48	PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. (10861757)	Ponniah S.... Alexander R.B.	2000	KLK3
49	Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. (9758071)	Price D.D.... Rafii A.	1998	INTS7
50	Myopathic evolution of an exertional muscle pain syndrome with phosphorylase b kinase deficiency. (2128163)	Carrier H.... Flechaire A.	1990	NEK3

Genes related to paine syndrome according to GeneCards:

(show top 50)    (show all 91)

id	Symbol	Description	Score	GeneCards Section Context
1	MSD	microcephaly with spastic diplegia (Paine syndrome)	11.1	Aliases & Descriptions
2	GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	11.0	Summaries
3	GRIN3B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	11.0	Summaries
4	GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	11.0	Summaries
5	GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	11.0	Summaries
6	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11.0	Summaries
7	GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	11.0	Summaries
8	GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	11.0	Summaries
9	TAC1	tachykinin, precursor 1	11.0	Publications
10	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
11	MSLNL	mesothelin-like	11.0
12	NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	11.0
13	LAPTM4A	lysosomal protein transmembrane 4 alpha	11.0
14	LPO	lactoperoxidase	11.0	Publications
15	GABPA	GA binding protein transcription factor, alpha subunit 60kDa	11.0	Publications
16	SGCE	sarcoglycan, epsilon	11.0	Publications
17	ANKLE2	ankyrin repeat and LEM domain containing 2	11.0
18	ZC3H12D	zinc finger CCCH-type containing 12D	11.0
19	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
20	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
21	INTS7	integrator complex subunit 7	11.0	Publications
22	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
23	GCH1	GTP cyclohydrolase 1	11.0	Publications
24	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
25	SLC6A6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	11.0
26	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0	Publications
27	ADRA1A	adrenoceptor alpha 1A	11.0	Publications
28	PRF1	perforin 1 (pore forming protein)	11.0
29	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
30	GFAP	glial fibrillary acidic protein	11.0	Publications
31	GPC3	glypican 3	11.0
32	MME	membrane metallo-endopeptidase	11.0	Publications
33	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
34	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
35	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
36	NPY	neuropeptide Y	11.0	Publications
37	CD14	CD14 molecule	11.0	Publications
38	TACR1	tachykinin receptor 1	11.0	Publications
39	SOD1	superoxide dismutase 1, soluble	11.0	Publications
40	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
41	POMC	proopiomelanocortin	11.0	Publications
42	EDN1	endothelin 1	11.0	Publications
43	IL10	interleukin 10	11.0	Publications
44	IL1A	interleukin 1, alpha	11.0	Publications
45	IL1B	interleukin 1, beta	11.0	Publications
46	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
47	TGFB1	transforming growth factor, beta 1	11.0	Publications
48	DRD2	dopamine receptor D2	11.0	Publications
49	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
50	TNF	tumor necrosis factor	11.0	Publications

Pathways related to paine syndrome according to GeneDecks:

(show top 50)    (show all 108)

id	Pathway	Score	Top Affiliating Genes
1	Pathogenesis of ALS36	10.7	GRIN3A, GRIN2A, GRIN2B, GRIN2C, GRIN3B, GRIN2D
2	Activation of NMDA receptor upon glutamate binding and postsynaptic events38	10.7	GRIN2C, GRIN2D, GRIN1, GRIN2A, GRIN2B
3	Glutamic acid signaling10	10.5	GRIN3B, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
4	Amyotrophic lateral sclerosis (ALS)20	10.5	GRIN2B, GRIN2C, GRIN2A, TNFRSF1A, SOD1, GRIN1
5	Alzheimers disease20	10.1	GRIN2D, IL1B, TNF, TNFRSF1A, GRIN1, GRIN2B
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	TNFRSF1A, CCL3, CCL4, IL2
7	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	9.9	SCN9A, KCNK2, TAC1, TACR1, GRIN2D, GRIN2C
8	Neuroactive ligand-receptor interaction20	9.8	ADRB2, GRIN2D, ADRA1A, LEP, GRIN1, GRIN2A
9	RAR-Gamma-RXR-Alpha Degradation36	9.8	CCL3, CXCL9, CCL5, CCL1, CCL17, CCL22
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.8	NR3C1, TNF, CALCA, IFNG, IL6, IL1B
11	Endothelin-1 Signaling Pathway36	9.7	IL6, CCL17, IL10, IL2, IL1B, IL1A
12	Molecular Mechanisms of Cancer36	9.7	TGFB1, CCL22, CCL17, CCL1, CCL5, GNB3
13	Graft-versus-host disease20	9.7	IL1A, IL2, PRF1, HLA-B, HLA-A
14	Cytokine Network36	9.6	IL10, IL2, IL6, IL1B, IL8, TNF
15	ERK Signaling36	9.6	TGFB1, CCL5, CCL3, CCL1, CCL17, IL6
16	Regulation of eIF4 and p70S6K36	9.6	CCL5, CCL3, CCL1, IL1A, CCL17, CCL22
17	Malaria20	9.6	IL1B, IL6, IL8, CCL2, IFNG, TNF
18	IL-6 Pathway36	9.5	CCL4, CCL2, IL8, CCL1, CXCL9, CCL3
19	NFAT Signaling and Lymphocyte Interactions36	9.5	CCL2, CCL17, CCL1, IL2, CCL4, CCL22
20	Toll-like receptor signaling pathway20	9.4	IL6, IL1B, CD14, TNF, CCL5, CCL3
21	PGC1Alpha Pathway36	9.2	TNFRSF1A, CCL5, CCL3, CCL1, CCL17, CCL22
22	Immune response MIF-mediated glucocorticoid regulation10	9.2	IL2, IL8, IFNG, TNF, NR3C1, IL6
23	Leishmaniasis20	9.1	TGFB1, HLA-DQB1, IFNG, IL1B, FCGR3A, IL1A
24	Chagas disease (American trypanosomiasis)20	9.0	IL6, ACE, IL2, IL1B, IL10, TGFB1
25	THC Differentiation Pathway36	8.9	HLA-DRB1, HLA-DQB1, IFNG, IL2, IL10, TNFRSF1A
26	Tuberculosis20	8.9	TGFB1, TNFRSF1A, TNF, HLA-DRB1, IFNG, HLA-DQB1
27	Chemokine Signaling36	8.9	CCL22, CCL2, CXCR3, CXCL9, IL8, CCL4
28	Akt Signaling36	8.9	CXCR3, CCL5, CCL3, CCL1, IL2, CCL17
29	Chemokine signaling pathway20	8.9	CCL2, GNB3, CCL5, CXCR3, CCL4, CCL17
30	SOCS Pathway36	8.7	CCL4, CCL5, CCL1, CCL17, IL10, IL1A
31	all-trans-Retinoic Acid Signaling in Brain36	8.7	IL2, CCL17, CCL1, CCL3, CCL5, TNF
32	MIF Regulation of Innate Immune Cells36	8.6	CXCL9, TNF, CCL5, CCL3, CCL1, CCL17
33	Tec Kinases Signaling36	8.6	GNB3, CCL4, IL8, CCL2, CCL22, CCL17
34	TGF-Beta Pathway36	8.6	TGFB1, IL10, TNFRSF1A, CCL5, CCL3, IL1A
35	STAT3 Pathway36	8.6	CCL3, CCL1, TNFRSF1A, CXCL9, CXCR3, TNF
36	PAK Pathway36	8.5	CCL17, CCL1, CCL5, TNF, TGFB1, CXCL9
37	JAK-STAT Pathway36	8.5	IL2, CCL4, IL8, IL6, IL1B, IL1A
38	Antioxidant Action of Vitamin-C36	8.4	CCL5, CCL2, CXCR3, CXCL9, TGFB1, TNFRSF1A
39	MAPK Family Pathway36	8.3	CCL2, TGFB1, TNFRSF1A, IL8, CCL1, CCL17
40	Allograft rejection20	8.3	HLA-A, IFNG, IL2, HLA-B, HLA-DQB1, HLA-DRB1
41	Rho Family GTPases36	8.3	CCL1, CCL3, CCL5, GNB3, TNF, TGFB1
42	p38 Signaling36	8.3	GNB3, CCL17, CCL5, IL2, IL6, IL8
43	Rheumatoid arthritis20	8.3	IL1B, HLA-DQB1, HLA-DRB1, TNF, TGFB1, IL6
44	Influenza A20	8.3	CCL2, CCL5, HLA-DQB1, IFNG, HLA-DRB1, HSPA1A
45	MIF Mediated Glucocorticoid Regulation36	8.3	CCL17, CCL2, CCL22, CCL4, IL6, IL2
46	Type I diabetes mellitus20	8.3	IL2, IL1B, IL1A, IFNG, HLA-A, TNF
47	Glucocorticoid Receptor Signaling36	8.1	IL10, TGFB1, NR3C1, TNFRSF1A, HSPA1A, CCL5
48	Cytokine-cytokine receptor interaction20	8.1	CXCR3, CXCL9, TGFB1, IL10, IL1A, IL1B
49	Autoimmune thyroid disease20	7.8	PRF1, HLA-DQB1, HLA-B, HLA-A, IL2, IL10
50	PEDF Induced Signaling36	7.8	IL10, GRIN2D, GRIN2C, GRIN2B, GRIN2A, GRIN1

Compounds related to paine syndrome according to GeneDecks:

(show top 50)    (show all 324)

id	Compound	Score	Top Affiliating Genes
1	sb 20358032 42	11.1	EDN1, NGF, TNF, IFNG, CCL5, CCL4
2	endotoxin32	9.7	CXCR3, CXCL9, TNFRSF1A, CAV1, HSPA1A, CCL3
3	pge232	9.7	TACR1, EDN1, CCL5, CCL3, CCL22, CCL4
4	methacholine32 9 9	11.6	ADRB2, TAC1, TACR1, TGFB1, CALCA, CCL5
5	mip 1alpha32	9.4	CCL5, CCL3, CCL2, CCL4, IL8, IL6
6	polymyxin b32	9.3	IL6, IFNG, CCL2, MBL2, IL8, IL1B
7	groalpha32	9.2	CCL4, IL8, IL6, IL1B, IL1A, IL10
8	dopamine32 9 18 9	12.2	ADRA1A, ADRB2, TAC1, TACR1, GFAP, HCRT
9	glutamate32	9.2	HCRT, DRD2, TNFRSF1A, CAV1, CALCA, CCL5
10	nmda32 42	10.2	GRIN2B, GRIN2A, GRIN1, CDKN3, LEP, GRIN2C
11	prostacyclin32	9.0	LEP, MME, TAC1, TACR1, ACE, EDN1
12	triptolide32	9.0	CCL5, CCL3, CCL2, CCL4, IL8, IL6
13	neopterin32	9.0	CHKB, GCH1, CD14, IL10, IL1A, ACPP
14	gm-csf32	9.0	TGFB1, TNF, IFNG, CCL5, CCL3, CCL2
15	tarc32	8.9	CXCR3, CXCL9, TNF, IFNG, CCL5, CCL3
16	cocaine32 9 9	10.9	ADRB2, NPY, POMC, LEP, GFAP, HCRT
17	histamine32 18	9.8	MME, CD14, IL2, CXCR3, CXCL9, TAC1
18	gold sodium thiomalate32	8.8	NR3C1, TNF, HLA-DRB1, IFNG, IL8, IL2
19	ccl332	8.8	CCL17, CCL2, CCL22, CCL4, IL8, IL6
20	oxygen32 18	9.7	CHKB, CAV1, CHKA, LPO, GCH1, INTS7
21	hydrocortisone32 9 9	10.6	IL1A, IL10, CD14, IL1B, IL2, IL6
22	il 1032	8.6	CCL5, CCL3, CCL17, CCL2, CCL4, IL8
23	prednisolone32 9 9	10.6	CD14, CHKB, CDKN3, IL10, IL2, NPY
24	epinephrine32 9 18 9	11.6	ADRA1A, ADRB2, NPY, POMC, TAC1, HCRT
25	rantes32	8.4	CCL17, CCL2, CCL22, CCL4, MBL2, IL6
26	estrogen32	8.4	GCH1, POMC, LEP, CHI3L1, CHKA, ADRB2
27	simvastatin32 34 42 9 18 9	13.3	TNFRSF1A, IL6, IL1A, CHKA, CHKB, IL10
28	herbimycin a32 42	9.2	IL1B, IL2, IL6, CCL2, IFNG, TNF
29	aspartate32	8.1	SOD2, TAC1, TACR1, GFAP, ACPP, NR3C1
30	pdtc32	8.1	CCL3, CCL2, IL8, IL6, IL1B, IL1A
31	tacrolimus32 34 9 9	11.0	IL2, IL10, CDKN3, CHKB, CCL4, CXCR3
32	acetylcholine32 9 18 9	10.9	NGF, NR3C1, DRD2, CAV1, CALCA, MB
33	testosterone32 9 18 9	10.8	CCL3, MB, IL1A, GRIN2B, MME, CHKB
34	superoxide32 18	8.7	ADRB2, SOD2, SOD1, CXCR3, PRF1, GFAP
35	indomethacin32 9 9	9.7	IL2, IL1B, IL1A, MME, CDKN3, LEP
36	norepinephrine32 9 18 9	10.5	GRIN1, CD14, CHKB, LEP, LPO, GCH1
37	actinomycin d32	7.4	CCL2, IL8, IL6, IL2, IL1B, IL1A
38	vitamin d32	7.3	CAV1, NR3C1, NGF, KLK3, ACPP, TGFB1
39	calcium32 9 18 9	10.2	PRF1, TAC1, TACR1, HCRT, ACPP, EDN1
40	creatinine32	7.0	NEK3, NPY, POMC, SOD2, CXCR3, CXCL9
41	paraffin32	6.9	NPY, CHKA, CHKB, MME, IL10, MB
42	vegf32	6.8	CAV1, CHKB, CD14, CDKN3, CALCA, CCL5
43	lactate32	6.7	ADRB2, NEK3, NPY, SOD2, SOD1, TGFB1
44	nitric oxide32 9 18 9	8.8	ADRB2, HLA-B, CAV1, CALCA, CABIN1, HSPA1A
45	arginine32	5.8	ADRB2, NPY, POMC, SOD2, SOD1, CXCR3
46	cycloheximide32	5.8	POMC, SOD2, PRF1, TGFB1, GFAP, EDN1
47	cyclosporin a32 42	6.6	TGFB1, EDN1, NGF, TNFRSF1A, TNF, HLA-B
48	serine32	5.5	CD14, YES1, CHKA, LEP, GCH1, GABPA
49	tyrosine32	5.1	CHKA, LPO, FCGR3A, GRIN2B, GRIN2A, GRIN1
50	dexamethasone32 42 34 9 9	8.9	HCRT, KLK3, NGF, NR3C1, TNFRSF1A, TNF

Cellular components related to paine syndrome according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	N-methyl-D-aspartate selective glutamate receptor complex	GO:017146	10.7	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN3A, GRIN3B
2	outer membrane-bounded periplasmic space	GO:030288	10.6	GRIN3B, GRIN1, GRIN3A, GRIN2D, GRIN2C, GRIN2B
3	terminal button	GO:043195	10.4	GRIN2A, GRIN2B, GRIN1, CALCA
4	postsynaptic membrane	GO:045211	10.4	GRIN2D, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN3A
5	axon	GO:030424	10.2	TGFB1, TAC1, ADRB2, DRD2, TNFRSF1A, MME
6	postsynaptic density	GO:014069	10.2	GRIN2A, NR3C1, GRIN3A, DRD2, GRIN1, GRIN2B
7	cell surface	GO:009986	10.0	TGFB1, TACR1, TNFRSF1A, CAV1, IL1A, GRIN2B
8	neuronal cell body	GO:043025	9.6	TGFB1, GRIN3A, SOD1, TAC1, GRIN3B, CCL2
9	external side of plasma membrane	GO:009897	9.6	TNF, CXCR3, CXCL9, ACE, FCGR3A, IFNG
10	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.6	HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
11	ER to Golgi transport vesicle membrane	GO:012507	8.4	HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
12	integral to plasma membrane	GO:005887	7.8	HLA-B, HLA-A, CAV1, GPC3, GRIN2C, GRIN2B
13	extracellular region	GO:005576	7.1	CCL17, LEP, NPY, CCL5, CCL3, CCL2
14	extracellular space	GO:005615	6.9	MBL2, LPO, CCL4, CCL22, CCL2, CCL17
15	plasma membrane	GO:005886	6.0	ADRA1A, CAV1, KCNK2, YES1, CD14, MME

Biological processes related to paine syndrome according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of excitatory postsynaptic membrane potential	GO:060079	10.8	HCRT, GRIN1, ADRB2, GRIN2A, GRIN2C, GRIN2B
2	long-term memory	GO:007616	10.7	TAC1, TACR1, GRIN2B, DRD2, GRIN1
3	response to amphetamine	GO:001975	10.6	GRIN2A, GRIN2B, SOD1, GRIN1, DRD2
4	response to pain	GO:048265	10.6	GCH1, CALCA, TRPA1, TAC1
5	positive regulation of action potential	GO:045760	10.6	TAC1, TACR1, ADRA1A
6	response to morphine	GO:043278	10.6	DRD2, IL1B, TACR1, TAC1, GRIN1
7	positive regulation of renal sodium excretion	GO:035815	10.6	DRD2, EDN1, TACR1, TAC1
8	associative learning	GO:008306	10.6	TAC1, GRIN2B, TACR1, DRD2
9	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.5	IL1B, TNF, IFNG
10	response to ozone	GO:010193	10.5	TACR1, IL1A, IL1B
11	positive regulation of synaptic transmission, cholinergic	GO:032224	10.5	TACR1, TAC1, IFNG
12	negative regulation of growth of symbiont in host	GO:044130	10.5	TNF, IFNG, MBL2, IL10
13	regulation of sensory perception of pain	GO:051930	10.4	IL1A, IL10, GRIN2A, EDN1, ADRB2, GRIN2D
14	sensory perception of pain	GO:019233	10.4	EDN1, MME, GRIN1, GRIN2A, NGF, TACR1
15	response to ethanol	GO:045471	10.3	GRIN2B, PRF1, TNFRSF1A, GRIN2A, TACR1, SOD1
16	elevation of cytosolic calcium ion concentration	GO:007204	10.3	TACR1, TAC1, CXCR3, ADRA1A, HCRT, EDN1
17	response to heat	GO:009408	10.2	CD14, SOD1, IL1B, TACR1, CCL2, CALCA
18	monocyte chemotaxis	GO:002548	10.2	IL6, CCL2, CCL3, CCL5, CALCA
19	negative regulation of blood pressure	GO:045776	10.2	GCH1, CALCA, DRD2, NPY
20	positive regulation of natural killer cell chemotaxis	GO:2000503	10.2	CCL5, CCL3, CCL4
21	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.2	IL1A, CHI3L1, IL1B, CCL3, TNF, DRD2
22	positive regulation of calcium ion transport	GO:051928	10.1	CCL3, CCL5, HCRT, CCL4
23	cellular response to organic cyclic compound	GO:071407	10.1	IL1B, CCL2, CCL3, CCL5, TNF, TGFB1
24	protein kinase B signaling cascade	GO:043491	10.1	IL1B, CCL5, TGFB1, TNF, CCL2, CCL3
25	lipopolysaccharide-mediated signaling pathway	GO:031663	10.1	CCL2, CCL3, CCL5, TNF, TGFB1, IL1B
26	regulation of long-term neuronal synaptic plasticity	GO:048169	10.0	GRIN2A, GRIN2B, GRIN1, DRD2
27	response to nicotine	GO:035094	10.0	DRD2, EDN1, NGF, TACR1
28	response to activity	GO:014823	9.9	TNF, NR3C1, CCL2, IL10, CCL5
29	synaptic transmission	GO:007268	9.9	GRIN1, KCNK2, GRIN2A, GRIN2B, GRIN2C, GRIN2D
30	calcium-mediated signaling	GO:019722	9.9	EDN1, CCL3, IL8, CXCR3, TNF
31	aging	GO:007568	9.9	IL1B, CCL2, CCL5, CALCA, ADRA1A, TGFB1
32	cellular calcium ion homeostasis	GO:006874	9.9	CCL5, CCL1, CAV1, GRIN1, CCL3, CCL2
33	MAPK cascade	GO:000165	9.8	IL1B, CCL2, CCL5, TNF, TGFB1, CAV1
34	response to mechanical stimulus	GO:009612	9.7	CAV1, CCL2, TNF, NGF, CHI3L1
35	response to glucocorticoid stimulus	GO:051384	9.7	IL10, IL6, CCL2, CCL5, CAV1, NGF
36	neutrophil chemotaxis	GO:030593	9.7	CCL3, EDN1, IFNG, IL1B, IL8, CCL2
37	cellular response to interleukin-1	GO:071347	9.7	CCL2, CHI3L1, IL8, EDN1, CCL5, CCL3
38	chemotaxis	GO:006935	9.7	CXCL9, CCL5, CCL3, CCL1, CCL17, CCL22
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.7	IL2, IL6, IFNG, TNF, TNFRSF1A, DRD2
40	cellular response to tumor necrosis factor	GO:071356	9.7	EDN1, CCL5, CCL3, CCL2, IL8, CHI3L1
41	cell surface receptor signaling pathway	GO:007166	9.7	CSNK1A1, CABIN1, ADRB2, IFNG, CCL2, CD14
42	cell-cell signaling	GO:007267	9.5	CCL3, CCL17, CCL4, IL2, IL1B, IL10
43	response to drug	GO:042493	9.3	CAV1, IFNG, CCL5, CCL2, GRIN2A, SOD1
44	regulation of blood pressure	GO:008217	9.3	TAC1, GCH1, LEP, GNB3, CALCA, ACE
45	response to hypoxia	GO:001666	9.3	TNFRSF1A, LEP, IL1A, IL1B, MB, EDN1
46	anti-apoptosis	GO:006916	9.2	TNF, CCL2, IL1B, IL10, IL1A, IL2
47	negative regulation of cell proliferation	GO:008285	8.9	SOD2, TGFB1, IL1B, TNF, IL8, IL6
48	inflammatory response	GO:006954	8.3	CCL3, CCL5, CALCA, TNF, TNFRSF1A, NGF
49	cytokine-mediated signaling pathway	GO:019221	8.2	TNFRSF1A, IL6, IFNG, HLA-B, HLA-DQB1, IL1B
50	immune response	GO:006955	7.5	HLA-DRB1, CCL4, CXCL9, HLA-DQB1, HLA-B, HLA-A

Molecular functions related to paine syndrome according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	N-methyl-D-aspartate selective glutamate receptor activity	GO:004972	10.7	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A
2	neurotransmitter binding	GO:042165	10.6	GRIN3A, GRIN2D, GRIN2B, GRIN2A, GRIN1, GRIN3B
3	extracellular-glutamate-gated ion channel activity	GO:005234	10.6	GRIN2B, GRIN2A, GRIN1, GRIN2C, GRIN2D, GRIN3B
4	glycine binding	GO:016594	10.6	GRIN3B, GRIN1, GRIN3A, GRIN2B
5	calcium channel activity	GO:005262	10.5	GRIN2A, GRIN2B, GRIN1, TRPA1, GRIN3B, GRIN3A
6	glutamate binding	GO:016595	10.3	GRIN2D, GRIN2A, GRIN1
7	ionotropic glutamate receptor binding	GO:035255	10.3	DRD2, GRIN2B, ADRB2
8	CCR5 chemokine receptor binding	GO:031730	10.1	CCL3, CCL5, CCL4
9	CCR1 chemokine receptor binding	GO:031726	10.1	CCL3, CCL4, CCL5
10	drug binding	GO:008144	9.8	CHKA, GRIN2B, DRD2, ACE, ADRB2
11	cytokine activity	GO:005125	9.6	IL6, CXCL9, IL10, IL1A, IL1B, CCL4
12	growth factor activity	GO:008083	9.3	TGFB1, NGF, IL6, IL2, IL1B, LEP
13	chemokine activity	GO:008009	9.2	CCL3, CCL1, CCL17, CCL2, CCL4, IL8
14	receptor binding	GO:005102	9.0	CAV1, CCL17, CCL2, MBL2, HLA-A, GRIN1