MCID: PLN005
MIFTS: 43

Palindromic Rheumatism malady

Categories: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 50 42 14 69
Hench-Rosenberg Syndrome 12 50
Hench's Syndrome 12 50
Palindromic Rheumatism Syndrome 50

Classifications:



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Disease Ontology 12 DOID:1166
ICD10 33 M12.3 M12.30
MeSH 42 C538103

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 50 palindromic rheumatism (pr) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. a pr attack often occurs suddenly without any obvious triggers or warning symptoms. any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. symptoms during episodes may include pain, swelling, stiffness and redness in and around the joints. some people may have fever and other systemic symptoms. between episodes, people with pr have no symptoms. the time between episodes may last from days to months. the underlying cause of pr is not known. some people with pr eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (ra). others may develop lupus and/or other systemic disorders. people with anti-ccp antibodies detected in a blood test appear more likely to develop ra. there has been some evidence to support that pr can be a presenting feature of ra (or part of the spectrum of ra), rather than a distinct condition.  treatment of pr is challenging, as it has not been studied in randomized trials.nonsteroidal anti-inflammatory drugs (nsaids) may be used to treat acute episodes. disease-modifying antirheumatic drugs (dmards) may be an option for those with refractory, frequent attacks.hydroxychloroquine (a dmard) reportedly may help control attacks and reduce the risk of progression to ra. last updated: 2/28/2017

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and arthritis, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include testes, lung and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

Wikipedia : 71 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.8 CRP HLA-DRB1 IL1B PADI4 PRTN3 PTPN22
2 arthritis 10.4
3 oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies 10.3 MEFV TNFRSF1A
4 spondylocostal dysostosis-hypospadias-intellectual disability syndrome 10.3 MEFV TNFRSF1A
5 intussusception 10.3 IL1B TNF
6 muckle-wells syndrome 10.3 IL1B MEFV TNFRSF1A
7 non-amyloid monoclonal immunoglobulin deposition disease 10.3 HLA-DRB1 PTPN22
8 candidiasis, familial, 4, autosomal recessive 10.3 MEFV TNF TNFRSF1A
9 tau syndrome 10.3 IL1B MEFV TNF
10 sacral nerve root cysts 10.3 HLA-A HLA-DRB1
11 mental retardation, autosomal dominant 22 10.3 IL1B MEFV TNFRSF1A
12 myeloid neoplasms associated with pdgfrb rearrangement 10.3 MEFV TNF
13 meier-gorlin syndrome 3 10.2 IL1B MEFV TNF
14 multiple epiphyseal dysplasia 10.2 TNF TNFRSF1A TNFRSF1B
15 immunoglobulin g deficiency 10.2 HLA-DRB1 IL1B TNF
16 nystagmus, congenital motor, autosomal recessive 10.2 HLA-A HLA-DRB1 TNF
17 aseptic meningitis 10.2 HLA-A HLA-DRB1 TNF
18 acinic cell breast carcinoma 10.2 TNF TNFRSF1A TNFRSF1B
19 aortic coarctation 10.2 HLA-A PTPN22 TNF
20 hepatitis 10.2 HLA-A HLA-DRB1 TNF
21 retinal cancer 10.2 CRP IL1B MEFV
22 peripheral artery disease 10.2 HLA-A HLA-DRB1 TNF
23 swine influenza 10.2 CRP HLA-DRB1 TNF
24 autosomal recessive pericentral pigmentary retinopathy 10.2 TNF TNFRSF1A
25 anterior corneal pigmentation 10.2 HLA-A HLA-DRB1 PTPN22
26 anaerobic meningitis 10.2 HLA-A HLA-DRB1 TNFRSF10B
27 occupational dermatitis 10.2 MRAP TNF TNFRSF1B
28 central nervous system lymphoma 10.2 HLA-A IL1B TNF
29 dermatomycosis 10.2 CRP MEFV TNF
30 bladder calculus 10.2 MRAP TNF TNFRSF1B
31 depressed scar 10.2 HLA-A HLA-DRB1 TNF
32 nephronophthisis 1, juvenile 10.2 MRAP TNF TNFRSF1B
33 parasitic helminthiasis infectious disease 10.2 HLA-A HLA-DRB1 TNF
34 cataract 10.2 CRP IL1B TNF
35 plummer's disease 10.2 CRP HLA-DRB1 TNF
36 kidney leiomyosarcoma 10.2 MEFV PRTN3 TNFRSF1A
37 strawberry gallbladder 10.2 CRP MEFV TNF
38 choreatic disease 10.1 HLA-DRB1 TNF TNFRSF1A TNFRSF1B
39 myiasis 10.1 CRP MEFV TNF
40 periodontosis 10.1 HLA-A PTPN22 TNF
41 neuropathy 10.1 CRP IL1B TNF
42 urticaria 10.1 CRP IL1B TNF
43 anthracosis 10.1 HLA-A MEFV MRAP
44 deafness, autosomal recessive 67 10.1 HLA-DRB1 IL1B TNF TNFRSF1B
45 newcastle disease 10.1 MRAP TNF TNFRSF1B
46 atrophy of prostate 10.1 CRP IL1B TNF
47 blepharochalasis 10.1 CRP IL1B TNF
48 mikulicz disease 10.1 ERBB3 IL1B TNF
49 chordoid meningioma 10.1 CRP IL1B TNF
50 senile cataract 10.1 IL1B MEFV TNF

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B

MGI Mouse Phenotypes related to Palindromic Rheumatism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 IL1B LAIR1 MEFV PADI4 PRTN3 PTPN22
2 immune system MP:0005387 9.73 CRP ERBB3 IL1B LAIR1 MEFV PADI4
3 neoplasm MP:0002006 9.1 TNFRSF10A TNFRSF1A TNFRSF1B ERBB3 IL1B TNF

Drugs & Therapeutics for Palindromic Rheumatism

Search Clinical Trials , NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

39
Testes, Lung, Neutrophil, Heart

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 116)
id Title Authors Year
1
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. ( 26235245 )
2015
2
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2015
3
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. ( 24623460 )
2014
4
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. ( 25028368 )
2014
5
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. ( 24797773 )
2014
6
Palindromic rheumatism: consider Whipple's disease. ( 23992271 )
2013
7
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. ( 22898224 )
2012
8
Palindromic rheumatism: a pre-rheumatoid arthritis state? ( 23028026 )
2012
9
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. ( 22665157 )
2012
10
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. ( 22859345 )
2012
11
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. ( 22536266 )
2012
12
Palindromic rheumatism. ( 21206416 )
2011
13
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. ( 20808171 )
2010
14
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. ( 20476860 )
2010
15
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. ( 19771490 )
2010
16
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. ( 19710217 )
2009
17
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. ( 19648311 )
2009
18
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. ( 18412310 )
2008
19
Magnetic resonance imaging of palindromic rheumatism. ( 18663450 )
2008
20
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. ( 18512803 )
2008
21
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. ( 17665427 )
2007
22
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. ( 17763205 )
2007
23
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? ( 18290263 )
2007
24
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. ( 16847371 )
2006
25
Short term palindromic rheumatism after clopidogrel use. ( 16611878 )
2006
26
Palindromic rheumatism: different genetic background implies a distinct disease entity. ( 17038462 )
2006
27
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. ( 16724377 )
2006
28
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. ( 17187097 )
2006
29
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. ( 16189657 )
2005
30
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. ( 15290752 )
2004
31
Palindromic rheumatism and other relapsing arthritis. ( 15454124 )
2004
32
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? ( 12730510 )
2003
33
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. ( 24387063 )
2002
34
Palindromic rheumatism. ( 12408287 )
2002
35
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. ( 12415587 )
2002
36
A patient with severe palindromic rheumatism and frequent episodes of pain. ( 11300148 )
2001
37
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. ( 10648016 )
2000
38
Palindromic rheumatism: effect of dietary manipulation. ( 10895376 )
2000
39
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. ( 10090159 )
1999
40
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. ( 10063316 )
1999
41
Sparing effect of hemiparesis on palindromic rheumatism. ( 9093804 )
1997
42
Remission in palindromic rheumatism during pregnancy. ( 8478889 )
1993
43
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. ( 1450509 )
1992
44
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. ( 1341421 )
1992
45
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. ( 1629832 )
1992
46
Palindromic rheumatism: a response to chloroquine. ( 2023196 )
1991
47
Coexistent Felty's syndrome and palindromic rheumatism. ( 1768169 )
1991
48
Palindromic rheumatism: a case history. ( 2396876 )
1990
49
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. ( 2612120 )
1989
50
HLA antigens in palindromic rheumatism. An Italian study. ( 3266740 )
1988

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2
Show member pathways
13.32 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
3
Show member pathways
13.19 IL1B PTPN22 TNF TNFRSF10A TNFRSF10B TNFRSF1A
4
Show member pathways
13.17 ERBB3 HLA-A HLA-DRB1 IL1B PRTN3 TNF
5
Show member pathways
12.79 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
6
Show member pathways
12.72 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7
Show member pathways
12.43 HLA-A TNF TNFRSF10A TNFRSF10B
8
Show member pathways
12.42 ERBB3 TNF TNFRSF1A TNFRSF1B
9
Show member pathways
12.41 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
10 12.33 HLA-A HLA-DRB1 TNF TNFRSF1A
11 12.23 IL1B PTPN22 TNF TNFRSF10B TNFRSF1A TNFRSF1B
12
Show member pathways
12.19 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
13
Show member pathways
12.15 HLA-DRB1 IL1B TNF TNFRSF1A
14 12.13 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
15
Show member pathways
12.1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16 12.09 HLA-DRB1 IL1B TNF TNFRSF1A
17
Show member pathways
11.9 TNF TNFRSF1A TNFRSF1B
18 11.9 IL1B TNF TNFRSF1B
19
Show member pathways
11.89 HLA-A HLA-DRB1 IL1B
20 11.81 HLA-DRB1 IL1B TNF
21 11.79 IL1B TNF TNFRSF1A
22 11.77 IL1B TNF TNFRSF1A TNFRSF1B
23 11.76 HLA-DRB1 IL1B TNF
24
Show member pathways
11.65 TNF TNFRSF1A TNFRSF1B
25 11.61 TNF TNFRSF1A TNFRSF1B
26
Show member pathways
11.57 IL1B TNF TNFRSF1A
28 11.46 TNF TNFRSF1A TNFRSF1B
29
Show member pathways
11.4 TNF TNFRSF1A TNFRSF1B
30
Show member pathways
11.29 TNF TNFRSF1A TNFRSF1B
31 11.18 TNF TNFRSF1A TNFRSF1B
32 11.15 IL1B TNF TNFRSF1A TNFRSF1B
33 11.13 HLA-DRB1 IL1B TNF
34
Show member pathways
10.95 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
35 10.86 IL1B TNF

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 ERBB3 HLA-A TNF TNFRSF10A TNFRSF10B TNFRSF1A
2 cell surface GO:0009986 9.1 HLA-A HLA-DRB1 TNF TNFRSF10A TNFRSF10B TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 HLA-A HLA-DRB1 LAIR1 MEFV PTPN22
2 cell surface receptor signaling pathway GO:0007166 9.94 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
3 regulation of apoptotic process GO:0042981 9.91 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
4 positive regulation of gene expression GO:0010628 9.91 CRP ERBB3 IL1B PTPN22 TNF
5 leukocyte migration GO:0050900 9.88 IL1B TNF TNFRSF10A TNFRSF10B
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 IL1B TNF TNFRSF10B TNFRSF1A
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 TNF TNFRSF10A TNFRSF10B
8 negative regulation of inflammatory response GO:0050728 9.8 MEFV TNFRSF1A TNFRSF1B
9 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
10 regulation of cell proliferation GO:0042127 9.8 ERBB3 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
11 cellular response to mechanical stimulus GO:0071260 9.76 IL1B TNFRSF10A TNFRSF10B TNFRSF1A
12 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.72 TNF TNFRSF1A TNFRSF1B
13 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF TNFRSF10A TNFRSF1B
14 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
15 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.65 TNFRSF10A TNFRSF10B
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B PTPN22 TNF
18 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.64 TNFRSF10A TNFRSF10B
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
20 response to lipopolysaccharide GO:0032496 9.63 IL1B PTPN22 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
21 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
22 negative regulation of lipid storage GO:0010888 9.61 CRP TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF TNFRSF1B
24 positive regulation of ceramide biosynthetic process GO:2000304 9.6 TNF TNFRSF1A
25 death-inducing signaling complex assembly GO:0071550 9.59 TNF TNFRSF1A
26 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
27 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.56 TNF TNFRSF10A TNFRSF10B TNFRSF1A
28 immune response GO:0006955 9.56 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
29 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
30 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF TNFRSF1A
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
32 inflammatory response GO:0006954 9.23 CRP IL1B MEFV TNF TNFRSF10A TNFRSF10B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 TRAIL binding GO:0045569 8.96 TNFRSF10A TNFRSF10B
2 tumor necrosis factor-activated receptor activity GO:0005031 8.92 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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52 Novoseek
54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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