MCID: PLN005
MIFTS: 45

Palindromic Rheumatism malady

Rare diseases category

Summaries for Palindromic Rheumatism

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NIH Rare Diseases:41 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and polyarteritis nodosa. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean fever), and among its related pathways are Inflammatory Response Pathway and 14-3-3 and Regulation of BAD Activity. The compounds tumour necrosis factor membrane form and lymphotoxin-alpha have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and neutrophil, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:9 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:63 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Aliases & Classifications for Palindromic Rheumatism

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Palindromic Rheumatism, Aliases & Descriptions:

Name: Palindromic Rheumatism 9 41 11 60
Hench-Rosenberg Syndrome 9 41
Hench's Syndrome 9 41
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 41
Palindromic Rheumatism Syndrome 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:1166
MeSH33 C538103
ICD9CM27 719.3, 719.30
ICD1025 M12.3

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.3PADI4, PTPN22, HLA-DRB1
2polyarteritis nodosa31.0MEFV
3arthritis31.0TNF, TNFRSF1A, IL1B
4connective tissue disease30.5PTPN22, TNF, HLA-DRB1
5synovitis30.1TNFRSF1B, TNF, TNFRSF1A, IL1B
6systemic lupus erythematosus29.4HLA-DRB1, TNFRSF1B, TNF, TNFRSF1A, PTPN22, PADI4
7pericarditis10.5MEFV
8erysipelas10.5MEFV
9adult-onset still's disease10.4TNFRSF1B
10leishmaniasis10.4TNFRSF1A
11vogt-koyanagi-harada disease10.4HLA-DRB1
12felty's syndrome10.3
13leprosy10.3HLA-DRB1
14intervertebral disc disease10.3IL1B
15relapsing fever10.3MEFV, TNFRSF1A
16myocardial infarction10.2
17antiphospholipid syndrome10.2
18primary hypertrophic osteoarthropathy10.2
19dermatitis10.2
20lupus erythematosus10.2
21abdominal aortic aneurysm10.2TNFRSF1B, TNFRSF1A
22lymphopenia10.2PTPN22, TNFRSF1B
23spondyloarthropathy 110.2TNFRSF1B, TNF
24psoriatic arthritis10.2TNF, TNFRSF1B
25thyroiditis10.2HLA-DRB1, PTPN22
26narcolepsy10.1TNFRSF1B, HLA-DRB1
27amyloidosis10.1TNFRSF1A, MEFV
28pleurisy10.1IL1B, MEFV
29crohn's disease10.1TNF, TNFRSF1B
30behcet's disease10.1MEFV, TNF, TNFRSF1B
31vasculitis10.1MEFV, TNF, TNFRSF1B
32periodic fever, familial10.1TNF, TNFRSF1A, MEFV
33familial mediterranean fever, ar10.1TNF, TNFRSF1A, MEFV
34viral hepatitis10.1TNFRSF1A, HLA-DRB1
35aids dementia complex10.0IL1B, TNF
36chorioamnionitis10.0IL1B, TNF
37interstitial lung disease10.0TNF, IL1B
38hyperthyroidism10.0PTPN22, HLA-DRB1
39malaria10.0IL1B, TNF
40cholangiocarcinoma10.0TNFRSF1A, TNFRSF1B
41skin disease10.0HLA-DRB1, IL1B
42toxic shock syndrome10.0TNF, IL1B
43hepatitis10.0TNFRSF1A, HLA-DRB1
44acute respiratory distress syndrome10.0TNF, IL1B
45uveitis10.0TNFRSF1A, TNF, TNFRSF1B
46respiratory failure10.0IL1B, TNF
47periodontitis10.0IL1B, TNF
48juvenile rheumatoid arthritis10.0HLA-DRB1, TNFRSF1B, TNF
49schizophrenia10.0TNFRSF1A, TNFRSF1B, HLA-DRB1
50hepatitis c10.0TNF, TNFRSF1B, HLA-DRB1

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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Drug clinical trials:

Search ClinicalTrials for Palindromic Rheumatism

Search NIH Clinical Center for Palindromic Rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

31
Heart, Lung, Neutrophil

Animal Models for Palindromic Rheumatism or affiliated genes

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Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
2
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
3
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
4
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
5
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
6
Palindromic rheumatism. (21206416)
2011
7
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
8
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
9
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
10
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
11
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
12
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
13
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
14
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
15
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
16
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
17
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
18
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
19
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
20
Palindromic rheumatism: a case history. (2396876)
1990
21
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
22
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988
23
Sulphasalazine for palindromic rheumatism. (2892559)
1988
24
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
25
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
26
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
27
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
28
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
29
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
30
Palindromic rheumatism: a review. (7021825)
1981
31
Palindromic rheumatism. (1086697)
1976
32
Letter: Palindromic rheumatism. (4548064)
1974
33
Letter: Palindromic rheumatism. (4830920)
1974
34
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
35
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
36
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
37
Palindromic rheumatism. (5296469)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
A case of palindromic rheumatism. (13992037)
1962
40
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14799163)
1951
44
Palindromic rheumatism. (14806892)
1950
45
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
46
Palindromic Rheumatism. (18623788)
1948
47
Palindromic rheumatism. (20264810)
1947
48
Palindromic rheumatism in children. (21019385)
1946
49
Palindromic Rheumatism. (20786547)
1946
50
Palindromic rheumatism. (21004709)
1945

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFRSF1B, TNFRSF1A
29.5TNFRSF1A, TNFRSF1B
39.4TNFRSF1A, TNF
4
Show member pathways
9.4TNF, TNFRSF1A
5
Show member pathways
9.4TNFRSF1A, TNF
69.1IL1B, TNF
79.1IL1B, TNF
89.1IL1B, TNF
99.1IL1B, TNF
10
Show member pathways
Serotonin Transporter Activity36
9.1IL1B, TNF
119.1IL1B, TNF
12
Show member pathways
9.0TNFRSF1A, TNF, TNFRSF1B
13
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.0TNFRSF1A, TNF, TNFRSF1B
14
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0TNFRSF1A, TNF, TNFRSF1B
15
Show member pathways
9.0TNFRSF1A, TNF, TNFRSF1B
16
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.0TNFRSF1A, TNF, TNFRSF1B
17
Show member pathways
Alternative NF-kappaB pathway36
9.0TNFRSF1B, TNF, TNFRSF1A
18
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.0TNFRSF1B, TNF, TNFRSF1A
199.0TNFRSF1B, TNF, TNFRSF1A
20
Show member pathways
9.0TNFRSF1A, TNF, TNFRSF1B
21
Show member pathways
9.0TNFRSF1A, TNF, TNFRSF1B
229.0TNFRSF1A, TNF, TNFRSF1B
23
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.0TNFRSF1A, TNF, TNFRSF1B
24
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0TNFRSF1A, TNF, TNFRSF1B
258.8TNFRSF1A, TNF, HLA-DRB1
26
Show member pathways
8.8TNF, MEFV, IL1B
27
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6TNF, TNFRSF1A, IL1B
28
Show member pathways
MAPK signaling pathway36
8.6IL1B, TNFRSF1A, TNF
29
Show member pathways
Alzheimers Disease36
8.6IL1B, TNFRSF1A, TNF
308.6TNF, TNFRSF1A, IL1B
31
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.6IL1B, TNFRSF1A, TNF
32
Show member pathways
8.6TNF, TNFRSF1A, IL1B
338.6IL1B, TNFRSF1A, TNF
348.5HLA-DRB1, TNF, IL1B
358.5HLA-DRB1, TNF, IL1B
368.5HLA-DRB1, TNF, IL1B
37
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
388.2TNFRSF1B, TNF, TNFRSF1A, IL1B
398.2TNFRSF1B, TNF, TNFRSF1A, IL1B
40
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
41
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
42
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
43
Show member pathways
8.2IL1B, TNFRSF1A, TNF, TNFRSF1B
44
Show member pathways
8.2IL1B, TNFRSF1A, TNF, TNFRSF1B
45
Show member pathways
8.0IL1B, TNFRSF1A, TNF, HLA-DRB1
46
Show member pathways
8.0IL1B, TNFRSF1A, TNF, HLA-DRB1
47
Show member pathways
8.0HLA-DRB1, TNF, TNFRSF1A, IL1B
488.0HLA-DRB1, TNF, TNFRSF1A, IL1B
49
Show member pathways
7.7TNFRSF1B, TNF, TNFRSF1A, PTPN22, IL1B
50
Show member pathways
7.5IL1B, TNFRSF1A, TNF, TNFRSF1B, HLA-DRB1

Compounds for genes affiliated with Palindromic Rheumatism

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Compounds related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1tumour necrosis factor membrane form289.9TNFRSF1A, TNFRSF1B
2lymphotoxin-alpha289.9TNFRSF1B, TNFRSF1A
3bcma439.7TNFRSF1A, TNF
4blys439.7TNFRSF1A, TNF
5tab-1439.6TNFRSF1A, TNF
6n,n-dimethylsphingosine43 5910.5TNF, IL1B
7tenidap43 2810.5TNF, IL1B
8anakinra43 1210.5TNF, IL1B
9cicaprost43 2810.5TNF, IL1B
10taurine chloramine439.4TNF, IL1B
11vesnarinone439.4IL1B, TNF
12toxin-1439.4TNF, IL1B
13manganese superoxide439.4TNFRSF1A, TNFRSF1B, TNF
14chloroquine43 2 49 28 1213.4TNF, TNFRSF1A, TNFRSF1B
15mip 1alpha439.4IL1B, TNF
16ceramide439.2TNF, TNFRSF1B, TNFRSF1A
17ro 31 8220439.1TNF, IL1B
18nash439.1TNF, TNFRSF1A
19cuprophan439.1IL1B, TNFRSF1A, TNFRSF1B
20il 10439.1IL1B, TNFRSF1B, TNF
21actinomycin439.0TNFRSF1A, IL1B, TNF
22leflunomide43 49 1211.0TNF, TNFRSF1A, IL1B
23ns 39843 5910.0TNF, IL1B, TNFRSF1A
24c2ceramide439.0IL1B, TNF, TNFRSF1A
25anisomycin43 1210.0TNF, IL1B, TNFRSF1A
26sp 60012543 5910.0TNFRSF1A, TNF, IL1B
27tgf beta1439.0TNFRSF1A, TNF, IL1B
28gold sodium thiomalate438.9TNF, HLA-DRB1, IL1B
29herbimycin a43 599.9IL1B, TNFRSF1A, TNF
30prostacyclin438.9TNF, IL1B, TNFRSF1A
31calcitriol43 59 24 1211.8TNF, IL1B, TNFRSF1A
32etanercept43 49 1210.6TNFRSF1B, TNFRSF1A, IL1B, TNF
33infliximab43 49 1210.6TNF, TNFRSF1B, IL1B, TNFRSF1A
34ivig438.6IL1B, TNFRSF1B, TNF, TNFRSF1A
35neopterin438.6TNFRSF1A, IL1B, TNF, TNFRSF1B
36thalidomide43 49 59 1211.6IL1B, TNFRSF1A, TNFRSF1B, TNF
37curcumin438.6TNFRSF1B, IL1B, TNF, TNFRSF1A
38fmlp438.6TNFRSF1A, IL1B, TNF, TNFRSF1B
39rantes438.6IL1B, TNFRSF1A, TNF, TNFRSF1B
40actinomycin d438.5IL1B, TNFRSF1A, TNF, TNFRSF1B
41pge2438.5TNFRSF1B, TNFRSF1A, TNF, IL1B
42superoxide43 249.5TNFRSF1B, TNFRSF1A, IL1B, TNF
43cycloheximide438.5IL1B, TNFRSF1B, TNFRSF1A, TNF
44arginine438.5PADI4, HLA-DRB1, TNFRSF1B, PTPN22
45dexamethasone43 49 28 1211.4TNFRSF1A, TNF, IL1B, TNFRSF1B
46endotoxin438.3MEFV, TNF, TNFRSF1A, TNFRSF1B, IL1B
47tyrosine438.2TNFRSF1B, MEFV, HLA-DRB1, TNFRSF1A, PTPN22
48vegf438.2IL1B, TNFRSF1A, TNF, TNFRSF1B
49nitric oxide43 24 1210.2TNF, TNFRSF1A, TNFRSF1B, IL1B
50methotrexate49 43 1210.0IL1B, TNFRSF1A, TNF, HLA-DRB1, TNFRSF1B

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451218.7TNFRSF1A, TNF, TNFRSF1B
2extracellular regionGO:00055768.2IL1B, TNFRSF1A, TNF, TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:00327159.7TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.6TNF, TNFRSF1A
3negative regulation of inflammatory responseGO:00507289.5TNFRSF1B, TNFRSF1A, MEFV
4sequestering of triglycerideGO:00307309.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:00605599.5IL1B, TNF
6positive regulation of fever generationGO:00316229.5IL1B, TNF
7positive regulation of heterotypic cell-cell adhesionGO:00341169.5IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:00450809.5IL1B, TNF
9regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.5TNF, IL1B
10negative regulation of lipid catabolic processGO:00509959.5IL1B, TNF
11positive regulation of NF-kappaB import into nucleusGO:00423469.4IL1B, TNF
12negative regulation of gene expressionGO:00106299.4TNFRSF1A, TNF
13lipopolysaccharide-mediated signaling pathwayGO:00316639.4TNF, IL1B
14positive regulation of mitosisGO:00458409.4IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:00454299.4TNF, IL1B
16protein kinase B signalingGO:00434919.4TNF, IL1B
17intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.4TNFRSF1B, TNF, TNFRSF1A
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.4IL1B, TNF
19cellular response to organic cyclic compoundGO:00714079.3IL1B, TNF
20positive regulation of interferon-gamma productionGO:00327299.3IL1B, TNF
21positive regulation of interleukin-6 productionGO:00327559.2IL1B, TNF
22positive regulation of JNK cascadeGO:00463309.1TNF, IL1B
23positive regulation of membrane protein ectodomain proteolysisGO:00510449.1IL1B, TNF, TNFRSF1B
24cellular response to mechanical stimulusGO:00712609.0IL1B, TNFRSF1A
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.9IL1B, TNFRSF1A, TNF
26MAPK cascadeGO:00001658.8IL1B, TNF
27cytokine-mediated signaling pathwayGO:00192218.8IL1B, TNFRSF1A, HLA-DRB1
28immune responseGO:00069558.6IL1B, TNFRSF1B, HLA-DRB1
29inflammatory responseGO:00069548.2IL1B, MEFV, TNFRSF1A, TNF, TNFRSF1B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.4TNFRSF1A, TNF
2tumor necrosis factor-activated receptor activityGO:00050319.2TNFRSF1A, TNFRSF1B

Products for genes affiliated with Palindromic Rheumatism

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Sources for Palindromic Rheumatism

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25ICD10
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29KEGG
33MeSH
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38NCIt
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