MCID: PLN005
MIFTS: 45

Palindromic Rheumatism malady

Summaries for Palindromic Rheumatism

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to arthritis and synovitis. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean fever), and among its related pathways are TGF-Beta Pathway and HTLV-I infection. The compounds fmlp and tumour necrosis factor membrane form have been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related mouse phenotypes are liver/biliary system and skeleton.

Disease Ontology:8 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:64 Palindromic Rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Aliases & Classifications for Palindromic Rheumatism

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

palindromic rheumatism 8 43 10 61
hench-rosenberg syndrome 8 43
hench's syndrome 8 43
recurrent episodes of pain, swelling, warmth and stiffness of joints 43
palindromic rheumatism syndrome 43


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Disease Ontology8 DOID:1166
ICD9CM27 719.3, 719.30
MeSH35 C538103
ICD1025 M12.3

Related Diseases for Palindromic Rheumatism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.2TNFRSF1A, TNF, IL1B
2synovitis30.4IL1B, TNF, TNFRSF1A, TNFRSF1B
3familial mediterranean fever30.2TNFRSF1A, TNF, MEFV
4systemic lupus erythematosus30.2TNFRSF1B, TNFRSF1A, TNF, HLA-DRB1, PADI4, PTPN22
5felty's syndrome10.3
6primary hypertrophic osteoarthropathy10.2
7antiphospholipid syndrome10.2
8polyarteritis nodosa10.2
9whipple disease10.2
10pericarditis10.0MEFV
11brucellosis10.0MEFV
12adult-onset still's disease10.0TNFRSF1B
13sjogren's syndrome10.0TNFRSF1B
14deficiency anemia10.0TNFRSF1B
15guillain-barre syndrome10.0TNFRSF1B
16erysipelas10.0MEFV
17hyperglycemia10.0TNFRSF1B
18polymyositis10.0TNFRSF1B
19celiac disease10.0PTPN22
20essential hypertension10.0TNFRSF1B
21myositis10.0TNFRSF1B
22dementia10.0TNFRSF1B
23common variable immune deficiency10.0TNFRSF1A
24mixed connective tissue disease10.0TNFRSF1B
25paracoccidioidomycosis10.0TNFRSF1A
26leishmaniasis10.0TNFRSF1A
27herpes simplex10.0TNFRSF1B
28vitiligo10.0PTPN22
29sarcoma10.0TNFRSF1B
30dermatitis10.0TNFRSF1B
31ectodermal dysplasia10.0TNFRSF1A
32lupus nephritis10.0TNFRSF1B
33leprosy10.0HLA-DRB1
34hidradenitis suppurativa10.0TNFRSF1B
35pemphigus vulgaris10.0HLA-DRB1
36pyoderma gangrenosum10.0MEFV
37myocarditis10.0TNFRSF1B
38pemphigus foliaceus10.0HLA-DRB1
39polymyalgia rheumatica10.0HLA-DRB1
40glomerulonephritis10.0IL1B
41periodontitis10.0IL1B
42acquired immunodeficiency syndrome10.0IL1B
43amyloidosis10.0MEFV, TNFRSF1A
44encephalitis10.0IL1B
45pulmonary fibrosis10.0IL1B
46mastitis10.0IL1B
47degenerative disc disease10.0IL1B
48psoriatic arthritis10.0TNFRSF1B, TNF
49crohn's disease10.0TNF, TNFRSF1B
50neutropenia10.0TNFRSF1A, TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Clinical Features for Palindromic Rheumatism

Drugs & Therapeutics for Palindromic Rheumatism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Palindromic Rheumatism

Drug clinical trials:

Search ClinicalTrials for Palindromic Rheumatism

Search NIH Clinical Center for Palindromic Rheumatism

Search CenterWatch for Palindromic Rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Palindromic Rheumatism:

33
Lung, Heart

Animal Models for Palindromic Rheumatism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Palindromic Rheumatism

Sources:
51PubMed
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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
2
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. (22536266)
2012
3
Palindromic rheumatism: a pre-rheumatoid arthritis state? (23028026)
2012
4
Palindromic rheumatism. (21206416)
2011
5
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
6
Magnetic resonance imaging of palindromic rheumatism. (18663450)
2008
7
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
8
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
9
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. (16847371)
2006
10
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. (16189657)
2005
11
Palindromic rheumatism. (12408287)
2002
12
A patient with severe palindromic rheumatism and frequent episodes of pain. (11300148)
2001
13
Palindromic rheumatism: effect of dietary manipulation. (10895376)
2000
14
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
15
Sparing effect of hemiparesis on palindromic rheumatism. (9093804)
1997
16
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
17
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. (1341421)
1992
18
Palindromic rheumatism: a response to chloroquine. (2023196)
1991
19
Palindromic rheumatism: a case history. (2396876)
1990
20
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
21
Sulphasalazine for palindromic rheumatism. (2892559)
1988
22
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
23
Failure to detect a lymphocyte imbalance during acute attacks of palindromic rheumatism. (3495391)
1987
24
Palindromic rheumatism. A clinical survey of sixty patients. (3423751)
1987
25
Palindromic rheumatism: you just have to think about it! (3490340)
1986
26
HLA antigens in palindromic rheumatism and palindromic onset rheumatoid arthritis. (3490893)
1986
27
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
28
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
29
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
30
Palindromic rheumatism: a review. (7021825)
1981
31
Palindromic rheumatism: an allergic manifestation? (300382)
1977
32
Palindromic rheumatism. (1086697)
1976
33
D-penicillamine in palindromic rheumatism. (1087173)
1976
34
Treatment of palindromic rheumatism with D-penicillamine. (1086121)
1976
35
Letter: Palindromic rheumatism. (4830920)
1974
36
Palindromic rheumatism: an unusual cause of the inflammatory joint. Two case reports and a review. (4812156)
1974
37
Tubular structures in endothelium in palindromic rheumatism. (4539021)
1972
38
Palindromic rheumatism: a request. (4538871)
1972
39
Palindromic rheumatism. What is it? (4227601)
1967
40
A case of palindromic rheumatism. (13992037)
1962
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14890929)
1951
44
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
45
Palindromic rheumatism; effective treatment with gold. (18866487)
1948
46
Palindromic rheumatism. (20264810)
1947
47
PALINDROMIC RHEUMATISM. (20324282)
1947
48
A unique heart tetralogy with palindromic rheumatism. (20257875)
1947
49
Palindromic rheumatism. (20278688)
1946
50
Palindromic Rheumatism. (20786209)
1945

Genetic Variations for Palindromic Rheumatism

Expression for genes affiliated with Palindromic Rheumatism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 56SinoBiological, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TNFRSF1A
210.0TNFRSF1A
39.9HLA-DRB1
4
Hide members
9.9HLA-DRB1
59.5TNFRSF1A, TNFRSF1B
6
Hide members
9.5TNFRSF1A, TNFRSF1B
7
Hide members
9.5TNFRSF1B, TNFRSF1A
8
Hide members
9.4TNFRSF1A, TNF
99.4TNF, TNFRSF1A
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
139.1IL1B, TNF
149.1TNF, IL1B
15
Hide members
9.1TNFRSF1B, TNFRSF1A, PTPN22
16
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
17
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
18
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
199.0TNF, TNFRSF1A, TNFRSF1B
20
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
21
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
229.0TNF, TNFRSF1A, TNFRSF1B
23
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
24
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
259.0TNF, TNFRSF1A, TNFRSF1B
26
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
279.0TNF, TNFRSF1A, TNFRSF1B
289.0TNFRSF1B, TNFRSF1A, TNF
29
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
30
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
31
Hide members
8.8IL1B, MEFV, TNF
32
Hide members
8.6IL1B, TNF, TNFRSF1A
33
Hide members
8.6IL1B, TNF, TNFRSF1A
348.6IL1B, TNF, TNFRSF1A
35
Hide members
8.6IL1B, TNF, TNFRSF1A
368.6IL1B, TNF, TNFRSF1A
378.5TNF, HLA-DRB1, IL1B
388.2TNFRSF1B, TNFRSF1A, TNF, IL1B
39
Hide members
8.2TNFRSF1B, TNFRSF1A, TNF, IL1B
40
Hide members
8.2TNFRSF1B, TNFRSF1A, TNF, IL1B
418.2TNFRSF1B, TNFRSF1A, TNF, IL1B
42
Hide members
8.2IL1B, TNF, TNFRSF1A, TNFRSF1B
43
Hide members
8.2IL1B, TNF, TNFRSF1A, TNFRSF1B
44
Hide members
8.0IL1B, HLA-DRB1, TNF, TNFRSF1A
45
Hide members
8.0TNFRSF1A, TNF, HLA-DRB1, IL1B
468.0TNFRSF1A, TNF, HLA-DRB1, IL1B
47
Hide members
7.5IL1B, HLA-DRB1, TNF, TNFRSF1A, TNFRSF1B

Compounds for genes affiliated with Palindromic Rheumatism

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1fmlp4510.4TNFRSF1B
2tumour necrosis factor membrane form299.9TNFRSF1B, TNFRSF1A
3lymphotoxin-α299.9TNFRSF1B, TNFRSF1A
4bcma459.8TNFRSF1A, TNF
5blys459.8TNF, TNFRSF1A
6tab-1459.7TNF, TNFRSF1A
7nash459.7TNF, TNFRSF1A
8endotoxin459.6MEFV, TNFRSF1A, TNFRSF1B
9n,n-dimethylsphingosine45 6010.5TNF, IL1B
10hydroxamate459.5TNFRSF1A, TNFRSF1B
11cicaprost45 2910.5IL1B, TNF
12anakinra45 1110.5IL1B, TNF
13taurine chloramine459.5TNF, IL1B
14vesnarinone459.5TNF, IL1B
15toxin-1459.4IL1B, TNF
16mip 1alpha459.4IL1B, TNF
17manganese superoxide459.4TNFRSF1B, TNFRSF1A, TNF
18ro 31 8220459.4IL1B, TNF
19chloroquine45 2 50 29 1113.4TNFRSF1B, TNFRSF1A, TNF
205 aminosalicylic acid459.3IL1B, TNF
21il-12459.3IL1B, TNF
22ceramide459.2TNF, TNFRSF1A, TNFRSF1B
23staurosporin459.2IL1B, TNF
24tpck459.1IL1B, TNF
25cuprophan459.1TNFRSF1B, TNFRSF1A, IL1B
26il 10459.1IL1B, TNF, TNFRSF1B
27actinomycin459.0IL1B, TNF, TNFRSF1A
28leflunomide50 45 1111.0IL1B, TNF, TNFRSF1A
29ns 39845 6010.0IL1B, TNF, TNFRSF1A
30rantes459.0IL1B, TNF, TNFRSF1A
31c2ceramide459.0TNFRSF1A, TNF, IL1B
32anisomycin45 1110.0IL1B, TNF, TNFRSF1A
33sp 60012545 6010.0IL1B, TNF, TNFRSF1A
34gold sodium thiomalate458.9IL1B, HLA-DRB1, TNF
35tgf beta1458.9IL1B, TNF, TNFRSF1A
36herbimycin a45 609.9TNFRSF1A, TNF, IL1B
37prostacyclin458.9TNFRSF1A, TNF, IL1B
38calcitriol45 60 11 2411.8TNFRSF1A, TNF, IL1B
39etanercept45 50 1110.6IL1B, TNF, TNFRSF1A, TNFRSF1B
40infliximab45 50 1110.6TNFRSF1B, TNFRSF1A, TNF, IL1B
41ivig458.6TNFRSF1B, TNFRSF1A, TNF, IL1B
42neopterin458.6IL1B, TNF, TNFRSF1A, TNFRSF1B
43thalidomide45 50 60 1111.6TNFRSF1B, TNFRSF1A, TNF, IL1B
44curcumin458.6IL1B, TNF, TNFRSF1A, TNFRSF1B
45actinomycin d458.5TNFRSF1B, TNFRSF1A, TNF, IL1B
46superoxide45 249.5IL1B, TNF, TNFRSF1A, TNFRSF1B
47arginine458.3PTPN22, PADI4, HLA-DRB1, TNFRSF1B
48dexamethasone45 50 29 1111.3TNFRSF1B, TNFRSF1A, TNF, IL1B
49vegf458.1TNFRSF1B, TNFRSF1A, TNF, IL1B
50methotrexate45 50 1110.0IL1B, HLA-DRB1, TNF, TNFRSF1A, TNFRSF1B

GO Terms for genes affiliated with Palindromic Rheumatism

Sources:
16Gene Ontology
See all sources

Cellular components related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.0TNF, TNFRSF1A, TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.7TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5TNFRSF1A, TNF
3negative regulation of inflammatory responseGO:0507289.5TNFRSF1B, TNFRSF1A, MEFV
4sequestering of triglycerideGO:0307309.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
6positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
7positive regulation of fever generationGO:0316229.4IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:0450809.4TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
10negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
11positive regulation of NF-kappaB import into nucleusGO:0423469.4IL1B, TNF
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4TNF, IL1B
13positive regulation of mitosisGO:0458409.3TNF, IL1B
14lipopolysaccharide-mediated signaling pathwayGO:0316639.3TNF, IL1B
15cellular response to organic cyclic compoundGO:0714079.2IL1B, TNF
16protein kinase B signaling cascadeGO:0434919.1TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.1IL1B, TNF
18positive regulation of nitric oxide biosynthetic processGO:0454299.0IL1B, TNF
19positive regulation of membrane protein ectodomain proteolysisGO:0510449.0IL1B, TNF, TNFRSF1B
20positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.9TNFRSF1A, TNF, IL1B
21positive regulation of interferon-gamma productionGO:0327298.8IL1B, TNF
22cytokine-mediated signaling pathwayGO:0192218.7IL1B, HLA-DRB1, TNFRSF1A
23inflammatory responseGO:0069548.2TNFRSF1B, TNFRSF1A, TNF, MEFV, IL1B

Molecular functions related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.5TNFRSF1A, TNFRSF1B

Products for genes affiliated with Palindromic Rheumatism

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Sources for Palindromic Rheumatism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet