MCID: PLN005
MIFTS: 52

Palindromic Rheumatism malady

Rare diseases category
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Summaries for Palindromic Rheumatism

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and arthritis. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Inflammatory Response Pathway. The compounds tumour necrosis factor membrane form and lymphotoxin-alpha have been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:8 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:65 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Aliases & Classifications for Palindromic Rheumatism

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

palindromic rheumatism 8 43 10 62
hench-rosenberg syndrome 8 43
hench's syndrome 8 43
recurrent episodes of pain, swelling, warmth and stiffness of joints 43
palindromic rheumatism syndrome 43


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Disease Ontology8 DOID:1166
ICD9CM27 719.3, 719.30
MeSH35 C538103
ICD1025 M12.3

Related Diseases for Palindromic Rheumatism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.2PADI4, PTPN22, HLA-DRB1
2arthritis31.2IL1B, TNFRSF1A, TNF
3connective tissue disease30.5TNF, PTPN22, HLA-DRB1
4polyarteritis nodosa30.4MEFV
5synovitis30.4TNF, TNFRSF1B, TNFRSF1A, IL1B
6familial mediterranean fever30.3TNFRSF1A, TNF, MEFV
7systemic lupus erythematosus30.1HLA-DRB1, TNFRSF1B, TNFRSF1A, PADI4, PTPN22, TNF
8felty's syndrome10.3
9antiphospholipid syndrome10.2
10primary hypertrophic osteoarthropathy10.2
11dermatitis10.2
12lupus erythematosus10.2
13myocardial infarction10.2
14pericarditis10.1MEFV
15erysipelas10.1MEFV
16adult-onset still's disease10.1TNFRSF1B
17leishmaniasis10.1TNFRSF1A
18vogt-koyanagi-harada disease10.1HLA-DRB1
19leprosy10.1HLA-DRB1
20degenerative disc disease10.1IL1B
21relapsing fever10.1TNFRSF1A, MEFV
22abdominal aortic aneurysm10.0TNFRSF1B, TNFRSF1A
23lymphopenia10.0TNFRSF1B, PTPN22
24ankylosing spondylitis10.0TNF, TNFRSF1B
25psoriatic arthritis10.0TNF, TNFRSF1B
26thyroiditis10.0PTPN22, HLA-DRB1
27malaria10.0TNF, HLA-DRB1
28crohn's disease10.0TNFRSF1B, TNF
29narcolepsy10.0HLA-DRB1, TNFRSF1B
30amyloidosis10.0TNFRSF1A, MEFV
31pleurisy10.0IL1B, MEFV
32behcet's disease10.0MEFV, TNF, TNFRSF1B
33vasculitis10.0TNFRSF1B, TNF, MEFV
34periodic fever, familial, autosomal dominant10.0MEFV, TNF, TNFRSF1A
35aids dementia complex10.0IL1B, TNF
36viral hepatitis10.0HLA-DRB1, TNFRSF1A
37chorioamnionitis10.0TNF, IL1B
38interstitial lung disease10.0TNF, IL1B
39hyperthyroidism10.0PTPN22, HLA-DRB1
40cerebral malaria10.0IL1B, TNF
41cholangiocarcinoma10.0TNFRSF1A, TNFRSF1B
42skin disease10.0HLA-DRB1, IL1B
43toxic shock syndrome10.0IL1B, TNF
44hepatitis10.0HLA-DRB1, TNFRSF1A
45adult respiratory distress syndrome10.0TNF, IL1B
46respiratory failure10.0IL1B, TNF
47uveitis10.0TNF, TNFRSF1A, TNFRSF1B
48periodontitis10.0TNF, IL1B
49juvenile rheumatoid arthritis10.0HLA-DRB1, TNF, TNFRSF1B
50schizophrenia10.0TNFRSF1A, HLA-DRB1, TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Palindromic Rheumatism

Search NIH Clinical Center for Palindromic Rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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33MalaCards
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MalaCards organs/tissues related to Palindromic Rheumatism:

33
Lung, Heart

Animal Models for Palindromic Rheumatism or affiliated genes

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37MGI
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Publications for Palindromic Rheumatism

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52PubMed
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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
2
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
3
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
4
Palindromic rheumatism. (21206416)
2011
5
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
6
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
7
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
8
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
9
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
10
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
11
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
12
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
13
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
14
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
15
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
16
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
17
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
18
Palindromic rheumatism: a case history. (2396876)
1990
19
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
20
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988
21
Sulphasalazine for palindromic rheumatism. (2892559)
1988
22
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
23
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
24
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
25
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
26
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
27
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
28
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
29
Palindromic rheumatism: a review. (7021825)
1981
30
Palindromic rheumatism. II. Failure to detect circulating immune complexes during acute episodes. (315208)
1979
31
Palindromic rheumatism. (1086697)
1976
32
Letter: Palindromic rheumatism. (4548064)
1974
33
Letter: Palindromic rheumatism. (4830920)
1974
34
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
35
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
36
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
37
Palindromic rheumatism. (5296469)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
A case of palindromic rheumatism. (13992037)
1962
40
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14799163)
1951
44
Palindromic rheumatism. (14806892)
1950
45
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
46
Palindromic Rheumatism. (18623788)
1948
47
Palindromic rheumatism. (20264810)
1947
48
Palindromic rheumatism in children. (21019385)
1946
49
Palindromic Rheumatism. (20786547)
1946
50
Palindromic rheumatism. (21004709)
1945

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 54R&D Systems, 60Thomson Reuters, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFRSF1B, TNFRSF1A
29.5TNFRSF1A, TNFRSF1B
39.4TNF, TNFRSF1A
4
Show member pathways
9.4TNFRSF1A, TNF
5
Show member pathways
9.4TNFRSF1A, TNF
69.1IL1B, TNF
79.1IL1B, TNF
89.1IL1B, TNF
99.1IL1B, TNF
109.1TNF, IL1B
11
Show member pathways
Serotonin Transporter Activity38
9.1IL1B, TNF
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0TNFRSF1B, TNFRSF1A, TNF
13
Show member pathways
Alternative NF-kappaB pathway38
9.0TNFRSF1B, TNF, TNFRSF1A
14
Show member pathways
9.0TNFRSF1A, TNFRSF1B, TNF
15
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0TNFRSF1A, TNF, TNFRSF1B
169.0TNF, TNFRSF1B, TNFRSF1A
17
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0TNF, TNFRSF1B, TNFRSF1A
18
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.0TNFRSF1B, TNFRSF1A, TNF
19
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.0TNFRSF1B, TNF, TNFRSF1A
20
Show member pathways
9.0TNFRSF1B, TNF, TNFRSF1A
21
Show member pathways
9.0TNFRSF1B, TNFRSF1A, TNF
229.0TNFRSF1A, TNFRSF1B, TNF
23
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.0TNFRSF1A, TNFRSF1B, TNF
24
Show member pathways
9.0TNF, TNFRSF1B, TNFRSF1A
258.8TNFRSF1A, HLA-DRB1, TNF
26
Show member pathways
8.8MEFV, IL1B, TNF
27
Show member pathways
Alzheimers Disease38
8.6TNFRSF1A, IL1B, TNF
28
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.6TNF, IL1B, TNFRSF1A
29
Show member pathways
8.6TNFRSF1A, TNF, IL1B
30
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6TNF, TNFRSF1A, IL1B
31
Show member pathways
MAPK signaling pathway38
8.6TNF, TNFRSF1A, IL1B
328.6TNF, TNFRSF1A, IL1B
338.6TNFRSF1A, TNF, IL1B
348.5TNF, HLA-DRB1, IL1B
358.5TNF, IL1B, HLA-DRB1
368.5HLA-DRB1, TNF, IL1B
37
Show member pathways
8.2IL1B, TNF, TNFRSF1B, TNFRSF1A
388.2TNFRSF1B, TNF, TNFRSF1A, IL1B
39
Show member pathways
8.2TNFRSF1A, TNF, TNFRSF1B, IL1B
40
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
41
Show member pathways
8.2TNFRSF1B, TNF, IL1B, TNFRSF1A
42
Show member pathways
8.2TNFRSF1A, TNF, TNFRSF1B, IL1B
438.2TNFRSF1A, IL1B, TNF, TNFRSF1B
44
Show member pathways
8.2TNF, TNFRSF1A, IL1B, TNFRSF1B
45
Show member pathways
8.0TNF, HLA-DRB1, IL1B, TNFRSF1A
46
Show member pathways
8.0IL1B, TNF, HLA-DRB1, TNFRSF1A
478.0HLA-DRB1, TNF, TNFRSF1A, IL1B
48
Show member pathways
8.0HLA-DRB1, TNF, TNFRSF1A, IL1B
49
Show member pathways
7.7TNF, IL1B, PTPN22, TNFRSF1A, TNFRSF1B
50
Show member pathways
7.5HLA-DRB1, TNFRSF1A, TNF, TNFRSF1B, IL1B

Compounds for genes affiliated with Palindromic Rheumatism

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Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 3BitterDB, 51PharmGKB, 24HMDB
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Compounds related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1tumour necrosis factor membrane form299.9TNFRSF1A, TNFRSF1B
2lymphotoxin-alpha299.9TNFRSF1B, TNFRSF1A
3bcma459.7TNFRSF1A, TNF
4blys459.7TNFRSF1A, TNF
5tab-1459.6TNFRSF1A, TNF
6n,n-dimethylsphingosine45 6110.5TNF, IL1B
7tenidap45 2910.5TNF, IL1B
8anakinra45 1110.5TNF, IL1B
9cicaprost45 2910.5TNF, IL1B
10taurine chloramine459.4TNF, IL1B
11vesnarinone459.4IL1B, TNF
12toxin-1459.4TNF, IL1B
13manganese superoxide459.4TNFRSF1A, TNFRSF1B, TNF
14chloroquine45 3 51 29 1113.4TNF, TNFRSF1A, TNFRSF1B
15mip 1alpha459.4IL1B, TNF
16ceramide459.2TNF, TNFRSF1B, TNFRSF1A
17ro 31 8220459.1TNF, IL1B
18nash459.1TNF, TNFRSF1A
19cuprophan459.1IL1B, TNFRSF1A, TNFRSF1B
20il 10459.1IL1B, TNFRSF1B, TNF
21actinomycin459.0TNFRSF1A, IL1B, TNF
22leflunomide45 51 1111.0TNF, TNFRSF1A, IL1B
23ns 39845 6110.0TNF, IL1B, TNFRSF1A
24c2ceramide459.0IL1B, TNF, TNFRSF1A
25anisomycin45 1110.0TNF, IL1B, TNFRSF1A
26sp 60012545 6110.0TNFRSF1A, TNF, IL1B
27tgf beta1459.0TNFRSF1A, TNF, IL1B
28gold sodium thiomalate458.9TNF, HLA-DRB1, IL1B
29herbimycin a45 619.9IL1B, TNFRSF1A, TNF
30prostacyclin458.9TNF, IL1B, TNFRSF1A
31calcitriol45 61 24 1111.8TNF, IL1B, TNFRSF1A
32etanercept45 51 1110.6TNFRSF1B, TNFRSF1A, IL1B, TNF
33infliximab45 51 1110.6TNF, TNFRSF1B, IL1B, TNFRSF1A
34ivig458.6IL1B, TNFRSF1B, TNF, TNFRSF1A
35neopterin458.6TNFRSF1A, IL1B, TNF, TNFRSF1B
36thalidomide45 51 61 1111.6IL1B, TNFRSF1A, TNFRSF1B, TNF
37curcumin458.6TNFRSF1B, IL1B, TNF, TNFRSF1A
38fmlp458.6TNFRSF1A, IL1B, TNF, TNFRSF1B
39rantes458.6IL1B, TNFRSF1A, TNF, TNFRSF1B
40actinomycin d458.5IL1B, TNFRSF1A, TNF, TNFRSF1B
41pge2458.5TNFRSF1B, TNFRSF1A, TNF, IL1B
42superoxide45 249.5TNFRSF1B, TNFRSF1A, IL1B, TNF
43cycloheximide458.5IL1B, TNFRSF1B, TNFRSF1A, TNF
44arginine458.5PADI4, HLA-DRB1, TNFRSF1B, PTPN22
45dexamethasone45 51 29 1111.4TNFRSF1A, TNF, IL1B, TNFRSF1B
46endotoxin458.3MEFV, TNF, TNFRSF1A, TNFRSF1B, IL1B
47tyrosine458.2TNFRSF1B, MEFV, HLA-DRB1, TNFRSF1A, PTPN22
48vegf458.2IL1B, TNFRSF1A, TNF, TNFRSF1B
49nitric oxide45 24 1110.2TNF, TNFRSF1A, TNFRSF1B, IL1B
50methotrexate51 45 1110.0IL1B, TNFRSF1A, TNF, HLA-DRB1, TNFRSF1B

GO Terms for genes affiliated with Palindromic Rheumatism

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16Gene Ontology
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Cellular components related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.7TNFRSF1A, TNF, TNFRSF1B
2extracellular regionGO:0055768.2IL1B, TNFRSF1A, TNF, TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.7TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.6TNFRSF1A, TNF
3negative regulation of inflammatory responseGO:0507289.5TNFRSF1A, MEFV, TNFRSF1B
4sequestering of triglycerideGO:0307309.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5TNF, IL1B
6positive regulation of heterotypic cell-cell adhesionGO:0341169.5TNF, IL1B
7positive regulation of fever generationGO:0316229.5IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.5IL1B, TNF
10negative regulation of lipid catabolic processGO:0509959.5IL1B, TNF
11positive regulation of NF-kappaB import into nucleusGO:0423469.4IL1B, TNF
12negative regulation of gene expressionGO:0106299.4TNFRSF1A, TNF
13lipopolysaccharide-mediated signaling pathwayGO:0316639.4TNF, IL1B
14positive regulation of mitosisGO:0458409.4IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.4IL1B, TNF
16protein kinase B signalingGO:0434919.4TNF, IL1B
17intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.4TNFRSF1B, TNF, TNFRSF1A
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, TNF
19cellular response to organic cyclic compoundGO:0714079.3IL1B, TNF
20positive regulation of interferon-gamma productionGO:0327299.3IL1B, TNF
21positive regulation of interleukin-6 productionGO:0327559.2IL1B, TNF
22positive regulation of JNK cascadeGO:0463309.1IL1B, TNF
23positive regulation of membrane protein ectodomain proteolysisGO:0510449.1IL1B, TNF, TNFRSF1B
24cellular response to mechanical stimulusGO:0712609.0IL1B, TNFRSF1A
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.9TNF, IL1B, TNFRSF1A
26MAPK cascadeGO:0001658.8IL1B, TNF
27cytokine-mediated signaling pathwayGO:0192218.8HLA-DRB1, TNFRSF1A, IL1B
28immune responseGO:0069558.6TNFRSF1B, IL1B, HLA-DRB1
29inflammatory responseGO:0069548.2TNF, TNFRSF1B, TNFRSF1A, MEFV, IL1B

Molecular functions related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4TNFRSF1A, TNF
2tumor necrosis factor-activated receptor activityGO:0050319.2TNFRSF1A, TNFRSF1B

Products for genes affiliated with Palindromic Rheumatism

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  • Antibodies
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Sources for Palindromic Rheumatism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet