MCID: PLN005
MIFTS: 43

Palindromic Rheumatism malady

Category: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

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Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 11 48 39 13 68
Hench-Rosenberg Syndrome 11 48
 
Hench's Syndrome 11 48
Palindromic Rheumatism Syndrome 48

Classifications:



External Ids:

Disease Ontology11 DOID:1166
ICD1030 M12.3, M12.30
MeSH39 C538103

Summaries for Palindromic Rheumatism

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NIH Rare Diseases:48 Palindromic rheumatism (pr) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. a pr attack often occurs suddenly without any obvious triggers or warning symptoms. any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. symptoms during episodes may include pain, swelling, stiffness and redness in and around the joints. some people may have fever and other systemic symptoms. between episodes, people with pr have no symptoms. the time between episodes may last from days to months. the underlying cause of pr is not known. some people with pr eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (ra). others may develop lupus and/or other systemic disorders. people with anti-ccp antibodies detected in a blood test appear more likely to develop ra. there has been some evidence to support that pr can be a presenting feature of ra (or part of the spectrum of ra), rather than a distinct condition.  treatment of pr is challenging, as it has not been studied in randomized trials.nonsteroidal anti-inflammatory drugs (nsaids) may be used to treat acute episodes. disease-modifying antirheumatic drugs (dmards) may be an option for those with refractory, frequent attacks.hydroxychloroquine (a dmard) reportedly may help control attacks and reduce the risk of progression to ra. last updated: 2/28/2017

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and arthritis, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways are LDL Oxidation in Atherogenesis and Hematopoietic cell lineage. Affiliated tissues include testes, neutrophil and lung, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and neoplasm.

Disease Ontology:11 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:71 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis29.8CRP, HLA-DRB1, IL1B, PADI4, PRTN3, PTPN22
2arthritis10.4
3oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies10.3MEFV, TNFRSF1A
4spondylocostal dysostosis-hypospadias-intellectual disability syndrome10.3MEFV, TNFRSF1A
5intussusception10.3IL1B, TNF
6muckle-wells syndrome10.3IL1B, MEFV, TNFRSF1A
7non-amyloid monoclonal immunoglobulin deposition disease10.3HLA-DRB1, PTPN22
8candidiasis, familial, 4, autosomal recessive10.3MEFV, TNF, TNFRSF1A
9tau syndrome10.3IL1B, MEFV, TNF
10sacral nerve root cysts10.3HLA-A, HLA-DRB1
11mental retardation, autosomal dominant 2210.3IL1B, MEFV, TNFRSF1A
12myeloid neoplasms associated with pdgfrb rearrangement10.3MEFV, TNF
13meier-gorlin syndrome 310.2IL1B, MEFV, TNF
14multiple epiphyseal dysplasia10.2TNF, TNFRSF1A, TNFRSF1B
15immunoglobulin g deficiency10.2HLA-DRB1, IL1B, TNF
16nystagmus, congenital motor, autosomal recessive10.2HLA-A, HLA-DRB1, TNF
17aseptic meningitis10.2HLA-A, HLA-DRB1, TNF
18acinic cell breast carcinoma10.2TNF, TNFRSF1A, TNFRSF1B
19aortic coarctation10.2HLA-A, PTPN22, TNF
20hepatitis10.2HLA-A, HLA-DRB1, TNF
21retinal cancer10.2CRP, IL1B, MEFV
22peripheral artery disease10.2HLA-A, HLA-DRB1, TNF
23swine influenza10.2CRP, HLA-DRB1, TNF
24autosomal recessive pericentral pigmentary retinopathy10.2TNF, TNFRSF1A
25anterior corneal pigmentation10.2HLA-A, HLA-DRB1, PTPN22
26anaerobic meningitis10.2HLA-A, HLA-DRB1, TNFRSF10B
27occupational dermatitis10.2MRAP, TNF, TNFRSF1B
28central nervous system lymphoma10.2HLA-A, IL1B, TNF
29dermatomycosis10.2CRP, MEFV, TNF
30bladder calculus10.2MRAP, TNF, TNFRSF1B
31depressed scar10.2HLA-A, HLA-DRB1, TNF
32nephronophthisis 1, juvenile10.2MRAP, TNF, TNFRSF1B
33parasitic helminthiasis infectious disease10.2HLA-A, HLA-DRB1, TNF
34cataract10.2CRP, IL1B, TNF
35plummer's disease10.2CRP, HLA-DRB1, TNF
36kidney leiomyosarcoma10.2MEFV, PRTN3, TNFRSF1A
37strawberry gallbladder10.2CRP, MEFV, TNF
38choreatic disease10.1HLA-DRB1, TNF, TNFRSF1A, TNFRSF1B
39myiasis10.1CRP, MEFV, TNF
40periodontosis10.1HLA-A, PTPN22, TNF
41neuropathy10.1CRP, IL1B, TNF
42urticaria10.1CRP, IL1B, TNF
43anthracosis10.1HLA-A, MEFV, MRAP
44deafness, autosomal recessive 6710.1HLA-DRB1, IL1B, TNF, TNFRSF1B
45newcastle disease10.1MRAP, TNF, TNFRSF1B
46atrophy of prostate10.1CRP, IL1B, TNF
47blepharochalasis10.1CRP, IL1B, TNF
48mikulicz disease10.1ERBB3, IL1B, TNF
49chordoid meningioma10.1CRP, IL1B, TNF
50senile cataract10.1IL1B, MEFV, TNF

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

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UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

MGI Mouse Phenotypes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF1A, TNFRSF1B
2MP:00053978.0IL1B, LAIR1, MEFV, PADI4, PRTN3, PTPN22
3MP:00053877.0CRP, ERBB3, IL1B, LAIR1, MEFV, PADI4

Drugs & Therapeutics for Palindromic Rheumatism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

36
Testes, Neutrophil, Lung, Heart

Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. (26235245)
2015
2
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. (26457478)
2015
3
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
4
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
5
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
6
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
7
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. (22898224)
2012
8
Palindromic rheumatism: a pre-rheumatoid arthritis state? (23028026)
2012
9
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
10
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
11
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. (22536266)
2012
12
Palindromic rheumatism. (21206416)
2011
13
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
14
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. (20476860)
2010
15
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
16
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. (19710217)
2009
17
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. (19648311)
2009
18
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
19
Magnetic resonance imaging of palindromic rheumatism. (18663450)
2008
20
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
21
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
22
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
23
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
24
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. (16847371)
2006
25
Short term palindromic rheumatism after clopidogrel use. (16611878)
2006
26
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
27
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. (16724377)
2006
28
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. (17187097)
2006
29
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. (16189657)
2005
30
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. (15290752)
2004
31
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
32
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? (12730510)
2003
33
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. (24387063)
2002
34
Palindromic rheumatism. (12408287)
2002
35
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. (12415587)
2002
36
A patient with severe palindromic rheumatism and frequent episodes of pain. (11300148)
2001
37
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. (10648016)
2000
38
Palindromic rheumatism: effect of dietary manipulation. (10895376)
2000
39
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
40
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
41
Sparing effect of hemiparesis on palindromic rheumatism. (9093804)
1997
42
Remission in palindromic rheumatism during pregnancy. (8478889)
1993
43
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
44
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. (1341421)
1992
45
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
46
Palindromic rheumatism: a response to chloroquine. (2023196)
1991
47
Coexistent Felty's syndrome and palindromic rheumatism. (1768169)
1991
48
Palindromic rheumatism: a case history. (2396876)
1990
49
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
50
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1B, TNF
29.7HLA-DRB1, IL1B, TNF
39.7HLA-DRB1, IL1B, TNF
49.7HLA-DRB1, IL1B, TNF
5
Show member pathways
9.7IL1B, TNF, TNFRSF1A
69.7IL1B, TNF, TNFRSF1A
79.6TNF, TNFRSF1A, TNFRSF1B
8
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
9
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
10
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
11
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
129.6TNF, TNFRSF1A, TNFRSF1B
139.6TNF, TNFRSF1A, TNFRSF1B
149.6IL1B, TNF, TNFRSF1B
15
Show member pathways
9.6HLA-A, HLA-DRB1, IL1B
16
Show member pathways
9.5HLA-DRB1, IL1B, TNF, TNFRSF1A
179.5HLA-DRB1, IL1B, TNF, TNFRSF1A
189.4IL1B, TNF, TNFRSF1A, TNFRSF1B
199.4IL1B, TNF, TNFRSF1A, TNFRSF1B
209.3HLA-A, HLA-DRB1, TNF, TNFRSF1A
229.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
23
Show member pathways
9.2HLA-A, TNF, TNFRSF10A, TNFRSF10B
24
Show member pathways
9.1ERBB3, TNF, TNFRSF1A, TNFRSF1B
25
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
27
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
28
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
298.8IL1B, PTPN22, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
30
Show member pathways
8.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
31
Show member pathways
8.5IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
32
Show member pathways
8.4HLA-A, HLA-DRB1, IL1B, TNF, TNFRSF10A, TNFRSF10B
33
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
34
Show member pathways
7.7ERBB3, HLA-A, HLA-DRB1, IL1B, PRTN3, TNF
35
Show member pathways
5.4CRP, DYNLT1, ERBB3, HLA-A, HLA-DRB1, IL1B

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.4HLA-A, HLA-DRB1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
2integral component of plasma membraneGO:00058878.1ERBB3, HLA-A, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complex assemblyGO:007155010.7TNF, TNFRSF1A
2positive regulation of ceramide biosynthetic processGO:200030410.7TNF, TNFRSF1A
3negative regulation of lipid catabolic processGO:005099510.6IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
6positive regulation of fever generationGO:003162210.6IL1B, TNF
7positive regulation of heterotypic cell-cell adhesionGO:003411610.6IL1B, TNF
8activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.6TNFRSF10A, TNFRSF10B
9regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.5IL1B, TNF
10sequestering of triglycerideGO:003073010.5IL1B, TNF
11negative regulation of lipid storageGO:001088810.5CRP, TNF
12regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.4TNFRSF10A, TNFRSF10B
13negative regulation of inflammatory responseGO:005072810.4MEFV, TNFRSF1A, TNFRSF1B
14lipopolysaccharide-mediated signaling pathwayGO:003166310.4IL1B, PTPN22, TNF
15intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.4TNF, TNFRSF1A, TNFRSF1B
16extrinsic apoptotic signaling pathwayGO:009719110.3TNF, TNFRSF10A, TNFRSF1B
17positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IL1B, TNF, TNFRSF1B
18regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF, TNFRSF1A
19activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.3TNF, TNFRSF10A, TNFRSF10B
20cellular response to mechanical stimulusGO:007126010.1IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A
21extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
22cell surface receptor signaling pathwayGO:000716610.0TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
23positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.0IL1B, TNF, TNFRSF10B, TNFRSF1A
24leukocyte migrationGO:005090010.0IL1B, TNF, TNFRSF10A, TNFRSF10B
25regulation of apoptotic processGO:00429819.9TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26immune system processGO:00023769.6HLA-A, HLA-DRB1, LAIR1, MEFV, PTPN22
27positive regulation of gene expressionGO:00106289.4CRP, ERBB3, IL1B, PTPN22, TNF
28response to lipopolysaccharideGO:00324969.3IL1B, PTPN22, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
29regulation of cell proliferationGO:00421279.1ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
30tumor necrosis factor-mediated signaling pathwayGO:00332099.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
31immune responseGO:00069558.9HLA-A, HLA-DRB1, IL1B, TNF, TNFRSF10A, TNFRSF10B
32inflammatory responseGO:00069548.8CRP, IL1B, MEFV, TNF, TNFRSF10A, TNFRSF10B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TRAIL bindingGO:004556910.2TNFRSF10A, TNFRSF10B
2tumor necrosis factor-activated receptor activityGO:00050319.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Sources for Palindromic Rheumatism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet