Aliases & Classifications for Palindromic Rheumatism

MalaCards integrated aliases for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 50 42 14 69
Hench-Rosenberg Syndrome 12 50
Hench's Syndrome 12 50
Palindromic Rheumatism Syndrome 50

Classifications:



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Disease Ontology 12 DOID:1166
ICD10 33 M12.3 M12.30
MeSH 42 C538103

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 50 palindromic rheumatism (pr) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. a pr attack often occurs suddenly without any obvious triggers or warning symptoms. any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. symptoms during episodes may include pain, swelling, stiffness, and redness in and around the joints. some people may have a fever and other systemic symptoms. between episodes, people with pr have no symptoms. the time between episodes may last from days to months. the underlying cause of pr is not known. some people with pr eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (ra). others may develop lupus and/or other systemic disorders. people with anti-ccp antibodies detected in a blood test appear more likely to develop ra. there has been some evidence to support that pr can be a presenting feature of ra (or part of the spectrum of ra), rather than a distinct condition.  treatment of pr is challenging, as it has not been studied in randomized trials.nonsteroidal anti-inflammatory drugs (nsaids) may be used to treat acute episodes. disease-modifying antirheumatic drugs (dmards) may be an option for those with refractory, frequent attacks.hydroxychloroquine (a dmard) reportedly may help control attacks and reduce the risk of progression to ra. last updated: 2/28/2017

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and systemic lupus erythematosus, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include testes, lung and neutrophil, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

Wikipedia : 72 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.5 CRP HLA-DRB1 IL1B PADI4 PTPN22 TNF
2 systemic lupus erythematosus 28.3 CRP HLA-DRB1 PRTN3 PTPN22 TNF TNFRSF1B
3 acute neonatal citrullinemia type i 10.9 MEFV TNFRSF1A
4 acute megakaryoblastic leukemia without down syndrome 10.9 MEFV TNFRSF1A
5 clopidogrel resistance 10.8 HLA-DRB1 PTPN22
6 breast hemangiopericytoma 10.8 HLA-DRB1 TNFRSF10A
7 craniometaphyseal dysplasia 10.8 MEFV TNF
8 alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome 10.7 HLA-DRB1 PTPN22
9 leigh syndrome with leukodystrophy 10.7 MEFV TNFRSF1A
10 ramsay hunt syndrome i 10.7 HLA-A HLA-DRB1
11 biemond syndrome 10.7 HLA-DRB1 TNF
12 migraine with brainstem aura 10.7 HLA-DRB1 TNF
13 sternal cleft 10.7 IL1B TNF
14 familial cold-induced inflammatory syndrome 1 10.7 IL1B MEFV TNFRSF1A
15 cardiac sarcoidosis 10.7 TNF TNFRSF1B
16 tabatznik syndrome 10.6 IL1B MEFV TNF
17 moved to 244450 10.6 HLA-DRB1 IL1B TNF
18 yao syndrome 10.6 IL1B MEFV TNF
19 pulmonary hypertension 10.6 IL1B TNF
20 iida kannari syndrome 10.6 HLA-DRB1 IL1B TNF
21 multiple epiphyseal dysplasia 10.6 TNF TNFRSF1A TNFRSF1B
22 lung disease 10.6 TNF TNFRSF1B
23 siderosis 10.6 HLA-A TNFRSF10A
24 peripheral nervous system disease 10.6 TNF TNFRSF1A TNFRSF1B
25 cerebellum cancer 10.6 TNF TNFRSF1B
26 neuromuscular disease 10.5 TNF TNFRSF1B
27 mosaic trisomy 1 10.5 HLA-DRB1 TNF
28 congenital nystagmus 10.5 IL1B MEFV TNF
29 choreatic disease 10.5 TNF TNFRSF1A TNFRSF1B
30 not otherwise specified 3-mga-uria type 10.5 HLA-A HLA-DRB1 TNF
31 aseptic meningitis 10.5 HLA-A HLA-DRB1 TNF
32 anterior corneal pigmentation 10.5 HLA-A HLA-DRB1 PTPN22
33 discoid lupus erythematosus of eyelid 10.5 HLA-DRB1 IL1B TNF
34 pericardium disease 10.5 HLA-A HLA-DRB1 TNF
35 axillary adenitis 10.5 CRP IL1B MEFV
36 dentinogenesis imperfecta 10.5 HLA-A HLA-DRB1 TNF
37 retinitis pigmentosa 75 10.5 TNF TNFRSF1A
38 eye carcinoma in situ 10.5 HLA-A HLA-DRB1 TNF
39 arthritis 10.4
40 osmotic diarrhea 10.4 HLA-A IL1B TNF
41 epstein-barr virus hepatitis 10.4 CRP HLA-DRB1 TNF
42 bladder calculus 10.4 MRAP TNF TNFRSF1B
43 dermatosis papulosa nigra 10.4 MRAP TNF TNFRSF1B
44 dermatomycosis 10.4 CRP MEFV TNF
45 intestinal disaccharidase deficiency 10.4 HLA-A PTPN22 TNF
46 plummer's disease 10.4 CRP HLA-DRB1 TNF
47 multiple sclerosis 5 10.4 MEFV TNF TNFRSF1A TNFRSF1B
48 louping ill 10.4 CRP MEFV TNF
49 membranoproliferative glomerulonephritis 10.4 MRAP TNF TNFRSF1B
50 causalgia 10.4 IL1B TNF TNFRSF1A

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Palindromic Rheumatism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 LAIR1 MEFV PADI4 PRTN3 PTPN22 TNF
2 immune system MP:0005387 9.73 CRP ERBB3 IL1B LAIR1 MEFV PADI4
3 neoplasm MP:0002006 9.1 ERBB3 IL1B TNF TNFRSF10A TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Palindromic Rheumatism

Search Clinical Trials , NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

39
Testes, Lung, Neutrophil, Heart

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 118)
id Title Authors Year
1
Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis. ( 28619044 )
2017
2
Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. ( 28771535 )
2017
3
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2015
4
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. ( 26235245 )
2015
5
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. ( 24623460 )
2014
6
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. ( 24797773 )
2014
7
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. ( 25028368 )
2014
8
Palindromic rheumatism: consider Whipple's disease. ( 23992271 )
2013
9
Palindromic rheumatism: a pre-rheumatoid arthritis state? ( 23028026 )
2012
10
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. ( 22665157 )
2012
11
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. ( 22859345 )
2012
12
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. ( 22536266 )
2012
13
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. ( 22898224 )
2012
14
Palindromic rheumatism. ( 21206416 )
2011
15
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. ( 20476860 )
2010
16
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. ( 20808171 )
2010
17
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. ( 19771490 )
2010
18
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. ( 19648311 )
2009
19
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. ( 19710217 )
2009
20
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. ( 18512803 )
2008
21
Magnetic resonance imaging of palindromic rheumatism. ( 18663450 )
2008
22
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. ( 18412310 )
2008
23
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? ( 18290263 )
2007
24
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. ( 17665427 )
2007
25
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. ( 17763205 )
2007
26
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. ( 16847371 )
2006
27
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. ( 16724377 )
2006
28
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. ( 17187097 )
2006
29
Short term palindromic rheumatism after clopidogrel use. ( 16611878 )
2006
30
Palindromic rheumatism: different genetic background implies a distinct disease entity. ( 17038462 )
2006
31
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. ( 16189657 )
2005
32
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. ( 15290752 )
2004
33
Palindromic rheumatism and other relapsing arthritis. ( 15454124 )
2004
34
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? ( 12730510 )
2003
35
Palindromic rheumatism. ( 12408287 )
2002
36
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. ( 24387063 )
2002
37
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. ( 12415587 )
2002
38
A patient with severe palindromic rheumatism and frequent episodes of pain. ( 11300148 )
2001
39
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. ( 10648016 )
2000
40
Palindromic rheumatism: effect of dietary manipulation. ( 10895376 )
2000
41
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. ( 10090159 )
1999
42
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. ( 10063316 )
1999
43
Sparing effect of hemiparesis on palindromic rheumatism. ( 9093804 )
1997
44
Remission in palindromic rheumatism during pregnancy. ( 8478889 )
1993
45
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. ( 1450509 )
1992
46
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. ( 1341421 )
1992
47
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. ( 1629832 )
1992
48
Palindromic rheumatism: a response to chloroquine. ( 2023196 )
1991
49
Coexistent Felty's syndrome and palindromic rheumatism. ( 1768169 )
1991
50
Palindromic rheumatism: a case history. ( 2396876 )
1990

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 32)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2
Show member pathways
13.32 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
3
Show member pathways
13.21 ERBB3 HLA-A HLA-DRB1 IL1B PRTN3 TNF
4
Show member pathways
13.19 IL1B PTPN22 TNF TNFRSF10A TNFRSF10B TNFRSF1A
5
Show member pathways
12.79 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
6
Show member pathways
12.72 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7
Show member pathways
12.43 HLA-A TNF TNFRSF10A TNFRSF10B
8
Show member pathways
12.42 ERBB3 TNF TNFRSF1A TNFRSF1B
9
Show member pathways
12.41 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
10 12.33 HLA-A HLA-DRB1 TNF TNFRSF1A
11 12.23 IL1B PTPN22 TNF TNFRSF10B TNFRSF1A TNFRSF1B
12
Show member pathways
12.19 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
13
Show member pathways
12.15 HLA-DRB1 IL1B TNF TNFRSF1A
14 12.13 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
15
Show member pathways
12.1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16 12.09 HLA-DRB1 IL1B TNF TNFRSF1A
17 11.81 HLA-DRB1 IL1B TNF
18 11.79 IL1B TNF TNFRSF1A
19 11.77 IL1B TNF TNFRSF1A TNFRSF1B
20 11.76 HLA-DRB1 IL1B TNF
21
Show member pathways
11.65 TNF TNFRSF1A TNFRSF1B
22 11.61 TNF TNFRSF1A TNFRSF1B
23
Show member pathways
11.57 IL1B TNF TNFRSF1A
25 11.46 TNF TNFRSF1A TNFRSF1B
26
Show member pathways
11.4 TNF TNFRSF1A TNFRSF1B
27
Show member pathways
11.29 TNF TNFRSF1A TNFRSF1B
28 11.16 TNF TNFRSF1A TNFRSF1B
29 11.15 IL1B TNF TNFRSF1A TNFRSF1B
30 11.11 HLA-DRB1 IL1B TNF
31
Show member pathways
10.95 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
32 10.85 IL1B TNF

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 ERBB3 HLA-A TNF TNFRSF10A TNFRSF10B TNFRSF1A
2 cell surface GO:0009986 9.1 HLA-A HLA-DRB1 TNF TNFRSF10A TNFRSF10B TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 CRP ERBB3 IL1B PTPN22 TNF
2 cell surface receptor signaling pathway GO:0007166 9.94 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
3 leukocyte migration GO:0050900 9.88 IL1B TNF TNFRSF10A TNFRSF10B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B TNF TNFRSF10B TNFRSF1A
5 negative regulation of inflammatory response GO:0050728 9.8 MEFV TNFRSF1A TNFRSF1B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7 regulation of cell proliferation GO:0042127 9.8 ERBB3 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.79 TNF TNFRSF10A TNFRSF10B
9 cellular response to mechanical stimulus GO:0071260 9.76 IL1B TNFRSF10A TNFRSF10B TNFRSF1A
10 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.74 TNF TNFRSF1A TNFRSF1B
11 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF TNFRSF10A TNFRSF1B
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B PTPN22 TNF
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
14 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.63 TNFRSF10A TNFRSF10B
15 response to lipopolysaccharide GO:0032496 9.63 IL1B PTPN22 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF TNFRSF1B
19 negative regulation of lipid storage GO:0010888 9.6 CRP TNF
20 positive regulation of ceramide biosynthetic process GO:2000304 9.59 TNF TNFRSF1A
21 death-inducing signaling complex assembly GO:0071550 9.58 TNF TNFRSF1A
22 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.56 TNF TNFRSF10A TNFRSF10B TNFRSF1A
23 immune response GO:0006955 9.56 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
24 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
25 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF TNFRSF1A
26 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
28 inflammatory response GO:0006954 9.23 CRP IL1B MEFV TNF TNFRSF10A TNFRSF10B
29 immune system process GO:0002376 10 HLA-A HLA-DRB1 LAIR1 MEFV PTPN22

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 TRAIL binding GO:0045569 8.96 TNFRSF10A TNFRSF10B
2 tumor necrosis factor-activated receptor activity GO:0005031 8.92 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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