Aliases & Classifications for Palindromic Rheumatism

MalaCards integrated aliases for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 72 49 41 14 69
Hench-Rosenberg Syndrome 12 49
Hench's Syndrome 12 49
Palindromic Rheumatism Syndrome 49

Classifications:



External Ids:

Disease Ontology 12 DOID:1166
ICD10 32 M12.3 M12.30
MeSH 41 C538103

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 49 Palindromic rheumatism (PR) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. A PR attack often occurs suddenly without any obvious triggers or warning symptoms. Any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. Symptoms during episodes may include pain, swelling, stiffness, and redness in and around the joints. Some people may have a fever and other systemic symptoms. Between episodes, people with PR have no symptoms. The time between episodes may last from days to months. The underlying cause of PR is not known. Some people with PR eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (RA). Others may develop lupus and/or other systemic disorders. People with anti-CCP antibodies detected in a blood test appear more likely to develop RA. There has been some evidence to support that PR can be a presenting feature of RA (or part of the spectrum of RA), rather than a distinct condition.  Treatment of PR is challenging, as it has not been studied in randomized trials.Nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to treat acute episodes. Disease-modifying antirheumatic drugs (DMARDs) may be an option for those with refractory, frequent attacks.Hydroxychloroquine (a DMARD) reportedly may help control attacks and reduce the risk of progression to RA. Last updated: 2/28/2017

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to arthritis and synovitis, and has symptoms including stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint and arthralgia. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include testes, neutrophil and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

Wikipedia : 72 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.9 HLA-DRB1 IL1B PTPN22 TNF TNFRSF1B
2 synovitis 30.4 CRP IL1B TNF
3 brucellosis 30.1 CRP MEFV TNF
4 periodontitis 30.0 CRP IL1B TNF
5 familial mediterranean fever 29.7 CRP IL1B MEFV TNF TNFRSF1A
6 polyarteritis nodosa 29.5 CRP MEFV PRTN3
7 rheumatoid arthritis 28.9 CRP HLA-DRB1 IL1B PADI4 PRTN3 PTPN22
8 systemic lupus erythematosus 28.2 CRP HLA-DRB1 IL1B PRTN3 PTPN22 TNF
9 inflammatory myopathy with abundant macrophages 10.6 MEFV TNFRSF1A
10 intermittent hydrarthrosis 10.6 MEFV TNFRSF1A
11 polyposis, gastric 10.5 IL1B TNF
12 autoimmune addison disease 10.5 HLA-DRB1 PTPN22
13 autoinflammation, panniculitis, and dermatosis syndrome 10.5 MEFV TNF
14 rheumatoid factor-negative juvenile idiopathic arthritis 10.5 HLA-DRB1 PTPN22
15 idiopathic recurrent pericarditis 10.5 MEFV TNFRSF1A
16 beryllium disease 10.5 HLA-DRB1 TNF
17 postherpetic neuralgia 10.5 HLA-A HLA-DRB1
18 microscopic polyangiitis 10.5 HLA-DRB1 TNF
19 staphylococcal toxic shock syndrome 10.5 IL1B TNF
20 familial cold autoinflammatory syndrome 1 10.4 IL1B MEFV TNFRSF1A
21 skin sarcoidosis 10.4 TNF TNFRSF1B
22 oligoarticular juvenile idiopathic arthritis 10.4 HLA-DRB1 PTPN22 TNF
23 systemic onset juvenile idiopathic arthritis 10.4 IL1B MEFV TNF
24 actinic prurigo 10.4 HLA-DRB1 IL1B TNF
25 blau syndrome 10.4 IL1B MEFV TNF
26 idiopathic neutropenia 10.4 HLA-DRB1 IL1B TNF
27 chronic gonococcal salpingitis 10.4 TNF TNFRSF1A TNFRSF1B
28 kashin-beck disease 10.4 IL1B TNF
29 chronic salpingitis 10.4 TNF TNFRSF1A TNFRSF1B
30 caplan's syndrome 10.4 HLA-A TNFRSF10A
31 helicobacter pylori infection 10.3 HLA-DRB1 IL1B TNF
32 rheumatoid lung disease 10.3 TNF TNFRSF1B
33 guillain-barre syndrome 10.3 TNF TNFRSF1A TNFRSF1B
34 nontuberculous mycobacterial lung disease 10.3 HLA-A HLA-DRB1 TNF
35 alveolar echinococcosis 10.3 HLA-A HLA-DRB1 TNF
36 vogt-koyanagi-harada disease 10.3 HLA-A HLA-DRB1 PTPN22
37 chronic beryllium disease 10.3 HLA-DRB1 TNF
38 granulomatous dermatitis 10.3 TNF TNFRSF1B
39 anterior uveitis 10.3 HLA-A PTPN22 TNF
40 rheumatic heart disease 10.3 HLA-A HLA-DRB1 TNF
41 dengue hemorrhagic fever 10.3 HLA-A HLA-DRB1 TNF
42 rubella 10.3 HLA-A HLA-DRB1 TNF
43 scleral disease 10.3 MRAP TNF TNFRSF1B
44 pustulosis of palm and sole 10.3 MRAP TNF TNFRSF1B
45 leishmaniasis 10.3 HLA-DRB1 IL1B TNF
46 hemorrhagic fever with renal syndrome 10.2 CRP HLA-DRB1 TNF
47 periodic fever, familial, autosomal dominant 10.2 MEFV TNF TNFRSF1A TNFRSF1B
48 pleurisy 10.2 CRP MEFV TNF
49 hypersensitivity reaction type iv disease 10.2 MRAP TNF TNFRSF1B
50 sarcoidosis 1 10.2 HLA-DRB1 IL1B TNF TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, arthralgia

MGI Mouse Phenotypes related to Palindromic Rheumatism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 PTPN22 TNF TNFRSF10A TNFRSF1A TNFRSF1B IL1B
2 immune system MP:0005387 9.77 TNF TNFRSF10A TNFRSF1A TNFRSF1B AGBL2 CRP
3 neoplasm MP:0002006 9.1 TNF TNFRSF10A TNFRSF1A TNFRSF1B ERBB3 IL1B

Drugs & Therapeutics for Palindromic Rheumatism

Search Clinical Trials , NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

38
Testes, Neutrophil, Lung, Heart

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 120)
# Title Authors Year
1
Is palindromic rheumatism amongst children a benign disease? ( 29439723 )
2018
2
What can palindromic rheumatism tell us? ( 29221602 )
2017
3
Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis. ( 28619044 )
2017
4
Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. ( 28771535 )
2017
5
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. ( 26235245 )
2015
6
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2015
7
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. ( 24797773 )
2014
8
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. ( 25028368 )
2014
9
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. ( 24623460 )
2014
10
Palindromic rheumatism: consider Whipple's disease. ( 23992271 )
2013
11
Palindromic rheumatism: a pre-rheumatoid arthritis state? ( 23028026 )
2012
12
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. ( 22898224 )
2012
13
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. ( 22859345 )
2012
14
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. ( 22665157 )
2012
15
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. ( 22536266 )
2012
16
Palindromic rheumatism. ( 21206416 )
2011
17
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. ( 20476860 )
2010
18
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. ( 20808171 )
2010
19
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. ( 19771490 )
2010
20
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. ( 19710217 )
2009
21
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. ( 19648311 )
2009
22
Magnetic resonance imaging of palindromic rheumatism. ( 18663450 )
2008
23
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. ( 18412310 )
2008
24
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. ( 18512803 )
2008
25
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. ( 17665427 )
2007
26
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. ( 17763205 )
2007
27
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? ( 18290263 )
2007
28
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. ( 17187097 )
2006
29
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. ( 16724377 )
2006
30
Palindromic rheumatism: different genetic background implies a distinct disease entity. ( 17038462 )
2006
31
Short term palindromic rheumatism after clopidogrel use. ( 16611878 )
2006
32
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. ( 16847371 )
2006
33
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. ( 16189657 )
2005
34
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. ( 15290752 )
2004
35
Palindromic rheumatism and other relapsing arthritis. ( 15454124 )
2004
36
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? ( 12730510 )
2003
37
Palindromic rheumatism. ( 12408287 )
2002
38
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. ( 24387063 )
2002
39
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. ( 12415587 )
2002
40
A patient with severe palindromic rheumatism and frequent episodes of pain. ( 11300148 )
2001
41
Palindromic rheumatism: effect of dietary manipulation. ( 10895376 )
2000
42
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. ( 10648016 )
2000
43
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. ( 10090159 )
1999
44
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. ( 10063316 )
1999
45
Sparing effect of hemiparesis on palindromic rheumatism. ( 9093804 )
1997
46
Remission in palindromic rheumatism during pregnancy. ( 8478889 )
1993
47
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. ( 1629832 )
1992
48
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. ( 1450509 )
1992
49
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. ( 1341421 )
1992
50
Coexistent Felty's syndrome and palindromic rheumatism. ( 1768169 )
1991

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2
Show member pathways
13.33 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
3
Show member pathways
13.24 ERBB3 HLA-A HLA-DRB1 IL1B PRTN3 TNF
4
Show member pathways
13.2 IL1B PTPN22 TNF TNFRSF10A TNFRSF10B TNFRSF1A
5
Show member pathways
12.79 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
6
Show member pathways
12.72 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7
Show member pathways
12.46 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
8
Show member pathways
12.43 HLA-A TNF TNFRSF10A TNFRSF10B
9
Show member pathways
12.41 ERBB3 TNF TNFRSF1A TNFRSF1B
10 12.34 HLA-A HLA-DRB1 TNF TNFRSF1A
11 12.25 IL1B PTPN22 TNF TNFRSF10B TNFRSF1A TNFRSF1B
12
Show member pathways
12.19 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
13
Show member pathways
12.16 HLA-DRB1 IL1B TNF TNFRSF1A
14
Show member pathways
12.16 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
15 12.11 HLA-DRB1 IL1B TNF TNFRSF1A
16 12.03 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
17
Show member pathways
11.96 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
18 11.81 HLA-DRB1 IL1B TNF
19 11.81 IL1B TNF TNFRSF1A TNFRSF1B
20 11.8 IL1B TNF TNFRSF1A
21 11.76 HLA-DRB1 IL1B TNF
22
Show member pathways
11.66 TNF TNFRSF1A TNFRSF1B
23 11.62 TNF TNFRSF1A TNFRSF1B
24
Show member pathways
11.57 IL1B TNF TNFRSF1A
26 11.48 TNF TNFRSF1A TNFRSF1B
27
Show member pathways
11.42 TNF TNFRSF1A TNFRSF1B
28
Show member pathways
11.27 TNF TNFRSF1A TNFRSF1B
29 11.19 TNF TNFRSF1A TNFRSF1B
30 11.15 HLA-DRB1 IL1B TNF
31 11.15 IL1B TNF TNFRSF1A TNFRSF1B
32
Show member pathways
10.94 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
33 10.86 IL1B TNF

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 ERBB3 HLA-A TNF TNFRSF10A TNFRSF10B TNFRSF1A
2 cell surface GO:0009986 9.1 HLA-A HLA-DRB1 TNF TNFRSF10A TNFRSF10B TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 CRP ERBB3 IL1B PTPN22 TNF
2 cell surface receptor signaling pathway GO:0007166 9.93 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
3 leukocyte migration GO:0050900 9.89 IL1B TNF TNFRSF10A TNFRSF10B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B TNF TNFRSF10B TNFRSF1A
5 negative regulation of inflammatory response GO:0050728 9.82 MEFV TNFRSF1A TNFRSF1B
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 TNF TNFRSF10A TNFRSF10B
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
8 regulation of cell proliferation GO:0042127 9.8 ERBB3 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
9 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.79 TNFRSF10A TNFRSF10B TNFRSF1B
10 cellular response to mechanical stimulus GO:0071260 9.76 IL1B TNFRSF10A TNFRSF10B TNFRSF1A
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.73 TNF TNFRSF1A TNFRSF1B
12 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF TNFRSF10A TNFRSF1B
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B PTPN22 TNF
15 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.64 TNFRSF10A TNFRSF10B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
17 response to lipopolysaccharide GO:0032496 9.63 IL1B PTPN22 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
18 positive regulation of ceramide biosynthetic process GO:2000304 9.61 TNF TNFRSF1A
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF TNFRSF1B
20 negative regulation of lipid storage GO:0010888 9.6 CRP TNF
21 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
22 death-inducing signaling complex assembly GO:0071550 9.58 TNF TNFRSF1A
23 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.56 TNF TNFRSF10A TNFRSF10B TNFRSF1A
24 immune response GO:0006955 9.56 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
25 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
26 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF TNFRSF1A
27 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
29 inflammatory response GO:0006954 9.23 CRP IL1B MEFV TNF TNFRSF10A TNFRSF10B
30 immune system process GO:0002376 10.02 HLA-A HLA-DRB1 LAIR1 MEFV PTPN22

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TRAIL binding GO:0045569 8.96 TNFRSF10A TNFRSF10B
2 tumor necrosis factor-activated receptor activity GO:0005031 8.92 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
3 protein binding GO:0005515 10.06 CRP DYNLT1 ERBB3 HLA-A IL1B LAIR1

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....