MCID: PLN005
MIFTS: 49

Palindromic Rheumatism malady

Summaries for Palindromic Rheumatism

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to arthritis and rheumatoid arthritis. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean fever), and among its related pathways are TGF-Beta Pathway and HTLV-I infection. The compounds fmlp and tumour necrosis factor membrane form have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are liver/biliary system and skeleton.

Disease Ontology:8 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:63 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Aliases & Classifications for Palindromic Rheumatism

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

palindromic rheumatism 8 42 10 60
hench-rosenberg syndrome 8 42
hench's syndrome 8 42
recurrent episodes of pain, swelling, warmth and stiffness of joints 42
palindromic rheumatism syndrome 42


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Disease Ontology8 DOID:1166
ICD9CM27 719.3, 719.30
MeSH34 C538103
ICD1025 M12.3

Related Diseases for Palindromic Rheumatism

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17GeneCards, 18GeneDecks
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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.1TNFRSF1A, TNF, IL1B
2rheumatoid arthritis31.1PTPN22, PADI4, HLA-DRB1
3connective tissue disease30.4PTPN22, HLA-DRB1, TNF
4synovitis30.4IL1B, TNF, TNFRSF1A, TNFRSF1B
5dermatitis30.2TNFRSF1B
6familial mediterranean fever30.2TNFRSF1A, TNF, MEFV
7systemic lupus erythematosus30.1TNFRSF1B, TNFRSF1A, TNF, HLA-DRB1, PADI4, PTPN22
8felty's syndrome10.3
9primary hypertrophic osteoarthropathy10.1
10antiphospholipid syndrome10.1
11rheumatic fever10.1
12polyarteritis nodosa10.1
13lupus erythematosus10.1
14myocardial infarction10.1
15pericarditis10.0MEFV
16brucellosis10.0MEFV
17adult-onset still's disease10.0TNFRSF1B
18sjogren's syndrome10.0TNFRSF1B
19deficiency anemia10.0TNFRSF1B
20guillain-barre syndrome10.0TNFRSF1B
21erysipelas10.0MEFV
22hyperglycemia10.0TNFRSF1B
23polymyositis10.0TNFRSF1B
24celiac disease10.0PTPN22
25essential hypertension10.0TNFRSF1B
26myositis10.0TNFRSF1B
27dementia10.0TNFRSF1B
28common variable immune deficiency10.0TNFRSF1A
29mixed connective tissue disease10.0TNFRSF1B
30paracoccidioidomycosis10.0TNFRSF1A
31leishmaniasis10.0TNFRSF1A
32herpes simplex10.0TNFRSF1B
33vitiligo10.0PTPN22
34sarcoma10.0TNFRSF1B
35ectodermal dysplasia10.0TNFRSF1A
36lupus nephritis10.0TNFRSF1B
37leprosy10.0HLA-DRB1
38hidradenitis suppurativa10.0TNFRSF1B
39pemphigus vulgaris10.0HLA-DRB1
40pyoderma gangrenosum10.0MEFV
41myocarditis10.0TNFRSF1B
42pemphigus foliaceus10.0HLA-DRB1
43polymyalgia rheumatica10.0HLA-DRB1
44glomerulonephritis10.0IL1B
45periodontitis10.0IL1B
46acquired immunodeficiency syndrome10.0IL1B
47amyloidosis10.0MEFV, TNFRSF1A
48encephalitis10.0IL1B
49pulmonary fibrosis10.0IL1B
50mastitis10.0IL1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Clinical Features for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Palindromic Rheumatism

Drug clinical trials:

Search ClinicalTrials for Palindromic Rheumatism

Search NIH Clinical Center for Palindromic Rheumatism

Search CenterWatch for Palindromic Rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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32MalaCards
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MalaCards organs/tissues related to Palindromic Rheumatism:

32
Heart, Lung

Animal Models for Palindromic Rheumatism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Palindromic Rheumatism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3TNFRSF1B, TNFRSF1A, TNF, MEFV, PTPN22
2MP:00053908.2IL1B, MEFV, TNFRSF1A, TNFRSF1B
3MP:00020067.9TNFRSF1B, TNFRSF1A, TNF, IL1B
4MP:00053767.4PTPN22, IL1B, MEFV, TNF, TNFRSF1A, TNFRSF1B
5MP:00053877.1PTPN22, PADI4, IL1B, MEFV, TNF, TNFRSF1A
6MP:00107687.0TNFRSF1B, TNFRSF1A, TNF, MEFV, IL1B, PADI4

Publications for Palindromic Rheumatism

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50PubMed
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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
2
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. (22898224)
2012
3
Palindromic rheumatism. (21206416)
2011
4
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
5
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
6
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. (20476860)
2010
7
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. (19648311)
2009
8
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
9
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
10
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. (17187097)
2006
11
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. (16724377)
2006
12
Short term palindromic rheumatism after clopidogrel use. (16611878)
2006
13
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
14
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. (15290752)
2004
15
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? (12730510)
2003
16
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. (10648016)
2000
17
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
18
Remission in palindromic rheumatism during pregnancy. (8478889)
1993
19
Coexistent Felty's syndrome and palindromic rheumatism. (1768169)
1991
20
Palindromic rheumatism: a response to chloroquine. (2023196)
1991
21
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
22
Palindromic rheumatism. A clinical survey of sixty patients. (3423751)
1987
23
Palindromic rheumatism with rheumatoid nodules: a case report with ultrastructural studies. (3954461)
1986
24
Palindromic rheumatism in two non-identical brothers with identical HLA including DR4. (3872102)
1985
25
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
26
Palindromic rheumatism. (6792350)
1981
27
Palindromic rheumatism. II. Failure to detect circulating immune complexes during acute episodes. (315208)
1979
28
Palindromic rheumatism. (317007)
1979
29
Palindromic rheumatism. Clinical and serum complement study. (843112)
1977
30
Letter: Palindromic rheumatism. (4548064)
1974
31
Letter: Palindromic rheumatism. (4830920)
1974
32
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
33
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
34
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
35
Hypersensitivity to sodium nitrate: a major causative factor in case of palindromic rheumatism. (5306174)
1969
36
Palindromic rheumatism. (5296469)
1966
37
Palindromic rheumatism, systemic lupus erythematosus, and circulating anticoagulant activity. (5298631)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
40
Palindromic rheumatism. (14799163)
1951
41
Palindromic rheumatism. (14806892)
1950
42
Treatment of So-called Palindromic Rheumatism with Gold Compounds. (18623797)
1949
43
Palindromic Rheumatism. (18623788)
1948
44
Palindromic rheumatism. (18876030)
1948
45
Palindromic rheumatism. (18864852)
1948
46
Palindromic rheumatism. (20288181)
1947
47
Palindromic rheumatism in children. (21019385)
1946
48
Palindromic Rheumatism. (20786547)
1946
49
Palindromic rheumatism. (21013614)
1946
50
Palindromic rheumatism. (21004709)
1945

Genetic Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Palindromic Rheumatism

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Pathways for genes affiliated with Palindromic Rheumatism

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 55SinoBiological, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TNFRSF1A
210.0TNFRSF1A
39.9HLA-DRB1
4
Hide members
9.9HLA-DRB1
59.5TNFRSF1A, TNFRSF1B
6
Hide members
9.5TNFRSF1A, TNFRSF1B
7
Hide members
9.5TNFRSF1B, TNFRSF1A
8
Hide members
9.4TNFRSF1A, TNF
99.4TNF, TNFRSF1A
109.1IL1B, TNF
119.1IL1B, TNF
129.1IL1B, TNF
139.1IL1B, TNF
149.1TNF, IL1B
15
Hide members
9.1TNFRSF1B, TNFRSF1A, PTPN22
16
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
17
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
18
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
199.0TNF, TNFRSF1A, TNFRSF1B
20
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
21
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
229.0TNF, TNFRSF1A, TNFRSF1B
23
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
24
Hide members
9.0TNFRSF1B, TNFRSF1A, TNF
259.0TNF, TNFRSF1A, TNFRSF1B
26
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
279.0TNF, TNFRSF1A, TNFRSF1B
289.0TNFRSF1B, TNFRSF1A, TNF
29
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.0TNF, TNFRSF1A, TNFRSF1B
30
Apoptosis and survival Apoptotic TNF-family pathways
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9.0TNF, TNFRSF1A, TNFRSF1B
31
Hide members
8.8IL1B, MEFV, TNF
32
Hide members
8.6IL1B, TNF, TNFRSF1A
33
Hide members
8.6IL1B, TNF, TNFRSF1A
348.6IL1B, TNF, TNFRSF1A
35
Hide members
8.6IL1B, TNF, TNFRSF1A
368.6IL1B, TNF, TNFRSF1A
378.5TNF, HLA-DRB1, IL1B
388.2TNFRSF1B, TNFRSF1A, TNF, IL1B
39
Hide members
8.2TNFRSF1B, TNFRSF1A, TNF, IL1B
40
Hide members
8.2TNFRSF1B, TNFRSF1A, TNF, IL1B
418.2TNFRSF1B, TNFRSF1A, TNF, IL1B
42
Hide members
8.2IL1B, TNF, TNFRSF1A, TNFRSF1B
43
Hide members
8.2IL1B, TNF, TNFRSF1A, TNFRSF1B
44
Hide members
8.0IL1B, HLA-DRB1, TNF, TNFRSF1A
45
Hide members
8.0TNFRSF1A, TNF, HLA-DRB1, IL1B
468.0TNFRSF1A, TNF, HLA-DRB1, IL1B
47
Hide members
7.5IL1B, HLA-DRB1, TNF, TNFRSF1A, TNFRSF1B

Compounds for genes affiliated with Palindromic Rheumatism

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1fmlp4410.4TNFRSF1B
2tumour necrosis factor membrane form289.9TNFRSF1B, TNFRSF1A
3lymphotoxin-α289.9TNFRSF1B, TNFRSF1A
4bcma449.8TNFRSF1A, TNF
5blys449.8TNFRSF1A, TNF
6tab-1449.7TNFRSF1A, TNF
7nash449.7TNF, TNFRSF1A
8endotoxin449.6TNFRSF1B, TNFRSF1A, MEFV
9n,n-dimethylsphingosine44 5910.5TNF, IL1B
10hydroxamate449.5TNFRSF1B, TNFRSF1A
11cicaprost44 2810.5IL1B, TNF
12anakinra44 1110.5TNF, IL1B
13vesnarinone449.5IL1B, TNF
14taurine chloramine449.5TNF, IL1B
15toxin-1449.4IL1B, TNF
16mip 1alpha449.4IL1B, TNF
17manganese superoxide449.4TNFRSF1B, TNF, TNFRSF1A
18ro 31 8220449.4IL1B, TNF
19chloroquine44 2 49 28 1113.4TNF, TNFRSF1A, TNFRSF1B
20il-12449.3TNF, IL1B
215 aminosalicylic acid449.3TNF, IL1B
22ceramide449.2TNF, TNFRSF1A, TNFRSF1B
23staurosporin449.2TNF, IL1B
24tpck449.1TNF, IL1B
25cuprophan449.1TNFRSF1A, TNFRSF1B, IL1B
26il 10449.1TNF, IL1B, TNFRSF1B
27actinomycin449.0TNFRSF1A, IL1B, TNF
28leflunomide49 44 1111.0IL1B, TNF, TNFRSF1A
29ns 39844 5910.0TNFRSF1A, IL1B, TNF
30rantes449.0IL1B, TNF, TNFRSF1A
31c2ceramide449.0IL1B, TNFRSF1A, TNF
32anisomycin44 1110.0TNF, IL1B, TNFRSF1A
33sp 60012544 5910.0TNF, IL1B, TNFRSF1A
34gold sodium thiomalate448.9TNF, HLA-DRB1, IL1B
35tgf beta1448.9TNFRSF1A, TNF, IL1B
36herbimycin a44 599.9TNF, IL1B, TNFRSF1A
37prostacyclin448.9IL1B, TNF, TNFRSF1A
38calcitriol44 59 11 2411.8IL1B, TNFRSF1A, TNF
39etanercept44 49 1110.6TNFRSF1B, TNFRSF1A, TNF, IL1B
40infliximab44 49 1110.6IL1B, TNFRSF1B, TNF, TNFRSF1A
41ivig448.6IL1B, TNFRSF1B, TNF, TNFRSF1A
42neopterin448.6TNFRSF1B, TNFRSF1A, TNF, IL1B
43thalidomide44 49 59 1111.6IL1B, TNF, TNFRSF1A, TNFRSF1B
44curcumin448.6TNFRSF1B, IL1B, TNFRSF1A, TNF
45actinomycin d448.5IL1B, TNF, TNFRSF1A, TNFRSF1B
46superoxide44 249.5IL1B, TNFRSF1A, TNF, TNFRSF1B
47arginine448.3PTPN22, TNFRSF1B, HLA-DRB1, PADI4
48dexamethasone44 49 28 1111.3TNFRSF1A, IL1B, TNF, TNFRSF1B
49vegf448.1IL1B, TNF, TNFRSF1A, TNFRSF1B
50methotrexate44 49 1110.0IL1B, HLA-DRB1, TNFRSF1A, TNFRSF1B, TNF

GO Terms for genes affiliated with Palindromic Rheumatism

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16Gene Ontology
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Cellular components related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.0TNF, TNFRSF1A, TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.7TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5TNFRSF1A, TNF
3negative regulation of inflammatory responseGO:0507289.5TNFRSF1B, TNFRSF1A, MEFV
4sequestering of triglycerideGO:0307309.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
6positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
7positive regulation of fever generationGO:0316229.4IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:0450809.4TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.4IL1B, TNF
10negative regulation of lipid catabolic processGO:0509959.4IL1B, TNF
11positive regulation of NF-kappaB import into nucleusGO:0423469.4IL1B, TNF
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4TNF, IL1B
13positive regulation of mitosisGO:0458409.3TNF, IL1B
14lipopolysaccharide-mediated signaling pathwayGO:0316639.3TNF, IL1B
15cellular response to organic cyclic compoundGO:0714079.2IL1B, TNF
16protein kinase B signaling cascadeGO:0434919.1TNF, IL1B
17positive regulation of interleukin-6 productionGO:0327559.1IL1B, TNF
18positive regulation of nitric oxide biosynthetic processGO:0454299.0IL1B, TNF
19positive regulation of membrane protein ectodomain proteolysisGO:0510449.0IL1B, TNF, TNFRSF1B
20positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.9TNFRSF1A, TNF, IL1B
21positive regulation of interferon-gamma productionGO:0327298.8IL1B, TNF
22cytokine-mediated signaling pathwayGO:0192218.7IL1B, HLA-DRB1, TNFRSF1A
23inflammatory responseGO:0069548.2TNFRSF1B, TNFRSF1A, TNF, MEFV, IL1B

Molecular functions related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.5TNFRSF1A, TNFRSF1B

Products for genes affiliated with Palindromic Rheumatism

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Sources for Palindromic Rheumatism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet