MCID: PLN005
MIFTS: 48

Palindromic Rheumatism malady

Category: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

About this section

Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 10 45 12 36 65
Hench-Rosenberg Syndrome 10 45
Hench's Syndrome 10 45
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 45
Palindromic Rheumatism Syndrome 45

Classifications:



External Ids:

Disease Ontology10 DOID:1166
ICD1027 M12.3, M12.30
MeSH36 C538103
UMLS65 C0085574, C0158178

Summaries for Palindromic Rheumatism

About this section
NIH Rare Diseases:45 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to systemic lupus erythematosus and rheumatoid arthritis, and has symptoms including stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint and arthralgia. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean Fever), and among its related pathways are LDL Oxidation in Atherogenesis and Transcription_NF-kB signaling pathway. Affiliated tissues include liver, prostate and lung, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:10 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:68 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

About this section

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus29.4CRP, HLA-DRB1, PADI4, PTPN22, TNF, TNFRSF1B
2rheumatoid arthritis28.2CRP, HLA-B, HLA-DRB1, IL1B, PADI4, PRTN3
3neonatal intrahepatic cholestasis due to citrin deficiency10.8MEFV, TNFRSF1A
4non-immunoglobulin-mediated membranoproliferative glomerulonephritis10.8MEFV, TNFRSF1A
5congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome10.8HLA-DRB1, TNF
6polycythemia10.7IL1B, TNF
7stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.7IL1B, TNF
8pustulosis of palm and sole10.7TNF, TNFRSF1B
9autoimmune polyglandular syndrome type 210.7HLA-DRB1, TNF
10best1 retinopathy10.6HLA-DRB1, TNF
11plantar nerve lesion10.6IL1B, TNF
12non-distal monosomy 10q10.6HLA-DRB1, TNF
13cerebral sarcoidosis10.6TNF, TNFRSF1B
14familial cold-induced inflammatory syndrome 110.6IL1B, MEFV, TNFRSF1A
15brain stem glioma10.6TNF, TNFRSF1B
16peyronie's disease10.6IL1B, TNF
17multiple sclerosis 510.6MEFV, TNF, TNFRSF1A
18androgen insensitivity syndrome, mild10.6HLA-DRB1, PTPN22, TNF
19cinca syndrome10.6IL1B, MEFV, TNFRSF1A
20muckle-wells syndrome10.6IL1B, MEFV, TNFRSF1A
21arthritis10.6
22telangiectasis10.5TNF, TNFRSF1A, TNFRSF1B
23precursor b lymphoblastic lymphoma/leukemia10.5TNF, TNFRSF1A, TNFRSF1B
24sarcoidosis, early-onset10.5IL1B, MEFV, TNF
25idiopathic spinal cord herniation10.5HLA-DRB1, IL1B, TNF
26membranous glomerulonephritis10.5TNF, TNFRSF1A, TNFRSF1B
27idiopathic juxtafoveal retinal telangiectasia10.5HLA-B, HLA-DRB1
28pyosalpinx10.5TNF, TNFRSF1A, TNFRSF1B
29mammary paget's disease10.5IL1B, TNF
30opiate dependence10.5TNFRSF10A, TNFRSF1B
31periventricular leukomalacia10.5HLA-A, HLA-B
32waardenburg syndrome type 410.5IL1B, TNF
33ovarian endometrioid cystadenoma10.5IL1B, PTPN22, TNF
34microsomia hemifacial radial defects10.4HLA-B, HLA-DRB1, TNF
35inflammatory bowel disease 310.4HLA-DRB1, IL1B, TNF
36hydromyelia10.4HLA-A, HLA-B
37hypercementosis10.4HLA-B, HLA-DRB1, TNF
38gonococcal bursitis10.4TNF, TNFRSF1B
39postauricular lymphadenitis10.4CRP, IL1B, MEFV
40liver fibroma10.4HLA-DRB1, IL1B, TNF
41anti-hla hyperimmunization10.4HLA-B, PTPN22, TNF
42rhinoscleroma10.4CRP, MEFV, TNF
43cholera10.4HLA-B, HLA-DRB1, TNF
44gonadal disease10.4CRP, IL1B, MEFV
45postinfectious encephalomyelitis10.4HLA-A, HLA-B, HLA-DRB1
46miliary tuberculosis10.4HLA-A, PTPN22, TNF
47psoriasis10.4HLA-A, HLA-B, HLA-DRB1
48intermediate uveitis10.4HLA-A, HLA-B, HLA-DRB1
49wells-jankovic syndrome10.4CRP, IL1B, TNFRSF1A
50bacterial conjunctivitis10.4CRP, TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

About this section

UMLS symptoms related to Palindromic Rheumatism:


stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, arthralgia

Drugs & Therapeutics for Palindromic Rheumatism

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

About this section

Anatomical Context for Palindromic Rheumatism

About this section

MalaCards organs/tissues related to Palindromic Rheumatism:

33
Liver, Prostate, Lung, Breast, Bone, Endothelial, Neutrophil

Animal Models for Palindromic Rheumatism or affiliated genes

About this section

MGI Mouse Phenotypes related to Palindromic Rheumatism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF1A, TNFRSF1B
2MP:00053977.8IL1B, MEFV, PADI4, PRTN3, PTPN22, TNF
3MP:00053876.9CRP, ERBB3, IL1B, MEFV, PADI4, PRTN3

Publications for Palindromic Rheumatism

About this section

Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
2
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
3
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
4
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
5
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
6
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
7
Palindromic rheumatism. (21206416)
2011
8
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
9
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
10
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
11
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
12
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
13
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
14
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
15
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
16
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
17
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
18
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
19
Palindromic rheumatism: a case history. (2396876)
1990
20
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
21
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988
22
Sulphasalazine for palindromic rheumatism. (2892559)
1988
23
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
24
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
25
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
26
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
27
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
28
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
29
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
30
Palindromic rheumatism: a review. (7021825)
1981
31
Palindromic rheumatism. (1086697)
1976
32
Letter: Palindromic rheumatism. (4548064)
1974
33
Letter: Palindromic rheumatism. (4830920)
1974
34
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
35
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
36
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
37
Palindromic rheumatism. (5296469)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
A case of palindromic rheumatism. (13992037)
1962
40
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14799163)
1951
44
Palindromic rheumatism. (14806892)
1950
45
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
46
Palindromic Rheumatism. (18623788)
1948
47
Palindromic rheumatism. (20264810)
1947
48
Palindromic rheumatism in children. (21019385)
1946
49
Palindromic Rheumatism. (20786547)
1946
50
Palindromic rheumatism. (21004709)
1945

Variations for Palindromic Rheumatism

About this section

Expression for genes affiliated with Palindromic Rheumatism

About this section
Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

About this section

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1B, TNF
29.7TNF, TNFRSF1A, TNFRSF1B
39.7TNF, TNFRSF1A, TNFRSF1B
49.7TNF, TNFRSF1A, TNFRSF1B
5
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
6
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
7
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
89.7IL1B, TNF, TNFRSF1A
99.6HLA-DRB1, IL1B, TNF
109.6HLA-DRB1, IL1B, TNF
119.6HLA-DRB1, IL1B, TNF
12
Show member pathways
9.4CRP, IL1B, TNF
139.4IL1B, TNF, TNFRSF1A, TNFRSF1B
149.4HLA-DRB1, IL1B, TNF, TNFRSF1A
15
Show member pathways
9.4HLA-DRB1, IL1B, TNF, TNFRSF1A
16
Show member pathways
9.1HLA-A, HLA-B, IL1B, TNF
17
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
18
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
19
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
20
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
218.9HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF1A
22
Show member pathways
8.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
23
Show member pathways
8.7HLA-A, HLA-B, TNF, TNFRSF10A, TNFRSF10B
24
Show member pathways
8.6HLA-A, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
25
Show member pathways
8.5IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
26
Show member pathways
8.3HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF1A
27
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
28
Show member pathways
7.9HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF10A
29
Show member pathways
6.6CRP, ERBB3, HLA-A, HLA-B, HLA-DRB1, IL1B

GO Terms for genes affiliated with Palindromic Rheumatism

About this section

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IL1B, TNF
3sequestering of triglycerideGO:003073010.5IL1B, TNF
4positive regulation of chemokine biosynthetic processGO:004508010.5IL1B, TNF
5death-inducing signaling complex assemblyGO:007155010.5TNF, TNFRSF1A
6positive regulation of NF-kappaB import into nucleusGO:004234610.5IL1B, TNF
7positive regulation of fever generationGO:003162210.4IL1B, TNF
8negative regulation of lipid catabolic processGO:005099510.4IL1B, TNF
9positive regulation of ceramide biosynthetic processGO:200030410.4TNF, TNFRSF1A
10regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
11protection from natural killer cell mediated cytotoxicityGO:004227010.3HLA-A, HLA-B
12positive regulation of T cell mediated cytotoxicityGO:000191610.3HLA-A, HLA-B
13regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF, TNFRSF1A
14positive regulation of phagocytosisGO:005076610.3IL1B, TNF
15regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.2TNFRSF10A, TNFRSF10B
16establishment of protein localization to plasma membraneGO:009000210.2TNF, TNFRSF1A
17necroptotic processGO:007026610.0TNFRSF10A, TNFRSF10B
18intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.0TNF, TNFRSF1A, TNFRSF1B
19antigen processing and presentationGO:00198829.9HLA-A, HLA-B, HLA-DRB1
20defense response to Gram-positive bacteriumGO:00508309.8CRP, HLA-A, TNF
21negative regulation of neurogenesisGO:00507689.6DYNLT1, IL1B
22cell surface receptor signaling pathwayGO:00071669.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
23extrinsic apoptotic signaling pathwayGO:00971919.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1B
24extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
25response to lipopolysaccharideGO:00324968.9IL1B, PTPN22, TNFRSF10A, TNFRSF10B, TNFRSF1B
26inflammatory responseGO:00069548.8CRP, IL1B, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
27multicellular organism developmentGO:00072758.7TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
28regulation of cell proliferationGO:00421278.5ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.7HLA-A, HLA-B

Sources for Palindromic Rheumatism

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet