MCID: PLN005
MIFTS: 44

Palindromic Rheumatism malady

Category: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

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Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 10 45 12 36 65
Hench-Rosenberg Syndrome 10 45
Hench's Syndrome 10 45
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 45
Palindromic Rheumatism Syndrome 45

Classifications:



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Disease Ontology10 DOID:1166
ICD1027 M12.3, M12.30
MeSH36 C538103
UMLS65 C0085574, C0158178

Summaries for Palindromic Rheumatism

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NIH Rare Diseases:45 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to systemic lupus erythematosus and neonatal intrahepatic cholestasis due to citrin deficiency. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean Fever), and among its related pathways are LDL Oxidation in Atherogenesis and Transcription_NF-kB signaling pathway. Affiliated tissues include bone, endothelial and breast, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:10 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:68 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus29.8CRP, HLA-DRB1, PADI4, PTPN22, TNF, TNFRSF1B
2neonatal intrahepatic cholestasis due to citrin deficiency10.5MEFV, TNFRSF1A
3non-immunoglobulin-mediated membranoproliferative glomerulonephritis10.5MEFV, TNFRSF1A
4congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome10.5HLA-DRB1, TNF
5polycythemia10.5IL1B, TNF
6stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.4IL1B, TNF
7pustulosis of palm and sole10.4TNF, TNFRSF1B
8autoimmune polyglandular syndrome type 210.4HLA-DRB1, TNF
9best1 retinopathy10.4HLA-DRB1, TNF
10plantar nerve lesion10.4IL1B, TNF
11non-distal monosomy 10q10.4HLA-DRB1, TNF
12cerebral sarcoidosis10.4TNF, TNFRSF1B
13familial cold-induced inflammatory syndrome 110.4IL1B, MEFV, TNFRSF1A
14brain stem glioma10.4TNF, TNFRSF1B
15peyronie's disease10.4IL1B, TNF
16multiple sclerosis 510.4MEFV, TNF, TNFRSF1A
17androgen insensitivity syndrome, mild10.4HLA-DRB1, PTPN22, TNF
18cinca syndrome10.4IL1B, MEFV, TNFRSF1A
19muckle-wells syndrome10.4IL1B, MEFV, TNFRSF1A
20telangiectasis10.4TNF, TNFRSF1A, TNFRSF1B
21precursor b lymphoblastic lymphoma/leukemia10.4TNF, TNFRSF1A, TNFRSF1B
22sarcoidosis, early-onset10.4IL1B, MEFV, TNF
23idiopathic spinal cord herniation10.4HLA-DRB1, IL1B, TNF
24membranous glomerulonephritis10.3TNF, TNFRSF1A, TNFRSF1B
25idiopathic juxtafoveal retinal telangiectasia10.3HLA-B, HLA-DRB1
26pyosalpinx10.3TNF, TNFRSF1A, TNFRSF1B
27mammary paget's disease10.3IL1B, TNF
28neuropathy10.3
29opiate dependence10.3TNFRSF10A, TNFRSF1B
30periventricular leukomalacia10.3HLA-A, HLA-B
31waardenburg syndrome type 410.3IL1B, TNF
32ovarian endometrioid cystadenoma10.3IL1B, PTPN22, TNF
33microsomia hemifacial radial defects10.3HLA-B, HLA-DRB1, TNF
34inflammatory bowel disease 310.3HLA-DRB1, IL1B, TNF
35hydromyelia10.3HLA-A, HLA-B
36hypercementosis10.3HLA-B, HLA-DRB1, TNF
37gonococcal bursitis10.3TNF, TNFRSF1B
38postauricular lymphadenitis10.3CRP, IL1B, MEFV
39liver fibroma10.3HLA-DRB1, IL1B, TNF
40anti-hla hyperimmunization10.3HLA-B, PTPN22, TNF
41rhinoscleroma10.3CRP, MEFV, TNF
42cholera10.3HLA-B, HLA-DRB1, TNF
43gonadal disease10.3CRP, IL1B, MEFV
44postinfectious encephalomyelitis10.3HLA-A, HLA-B, HLA-DRB1
45miliary tuberculosis10.3HLA-A, PTPN22, TNF
46psoriasis10.2HLA-A, HLA-B, HLA-DRB1
47hepatocellular carcinoma10.2
48hepatitis10.2
49thyroiditis10.2
50endotheliitis10.2

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

33
Bone, Endothelial, Breast, Bone marrow, Neutrophil, Appendix, Prefrontal cortex

Animal Models for Palindromic Rheumatism or affiliated genes

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MGI Mouse Phenotypes related to Palindromic Rheumatism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF1A, TNFRSF1B
2MP:00053977.8IL1B, MEFV, PADI4, PRTN3, PTPN22, TNF
3MP:00053876.9CRP, ERBB3, IL1B, MEFV, PADI4, PRTN3

Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. (25505240)
2015
2
Impact of loop electrosurgical excision procedure for cervical intraepithelial neoplasia on HIV-1 genital shedding: a prospective cohort study: population and statistical queries. (24428452)
2014
3
Serosurvey and Observational Study of US Army Veterinary Corps Officers for Q Fever Antibodies from 1989 to 2008. (23859558)
2013
4
Quantitative genetic analysis of retinal degeneration in the blind cavefish Astyanax mexicanus. (23437360)
2013
5
Descemet stripping automated endothelial keratoplasty for bullous keratopathy with an irregular posterior surface. (23846407)
2013
6
Rapidly destructive arthropathy of the hip joint in patients with rheumatoid arthritis. (22691675)
2012
7
A SPR aptasensor for detection of avian influenza virus H5N1. (23112728)
2012
8
Letter to the editor: Multimodal treatment of co-existent callosal cavernous malformation and anterior communicating artery aneurysm associated with an infraoptic anterior cerebral artery. (21556861)
2012
9
A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer. (21807637)
2011
10
Targeting HTLV-1 activation of NFI_B in mouse models and ATLL patients. (21994759)
2011
11
Effects of solid hyaluronic acid film on postoperative fibrous scar formation after strabismus surgery in animals. (20873696)
2011
12
A novel mutation in SLC37A4 gene in a Sri Lankan boy with glycogen storage disease type Ib associated with very early onset neutropenia. (21629566)
2011
13
Effect of physical activity and t-786C polymorphism in blood pressure and blood flow in the elderly]. (20835679)
2010
14
Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function. (20042668)
2010
15
Subungual keratoacanthoma: the importance of accurate diagnosis. (20719897)
2010
16
Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). (19169684)
2009
17
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. (19144990)
2009
18
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. (17617578)
2007
19
Association of genetic variation within UBL5 with phenotypes of metabolic syndrome. (17036923)
2006
20
Ziprasidone- and lithium-induced neuroleptic malignant syndrome. (16352776)
2006
21
Visceral manifestations of Klippel-TrAcnaunay syndrome. (16284144)
2005
22
Structural and functional abnormality of systemic microvessels in cardiac syndrome X. (15871852)
2005
23
Muscle invasive schistosomal squamous cell carcinoma of the urinary bladder: frequency and prognostic significance of p53, BCL-2, HER2/neu, and proliferation (MIB-1). (14991535)
2004
24
Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse. (15132433)
2004
25
Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis. (15170923)
2004
26
Tumor necrosis factor-alpha-induced apoptosis of human coronary artery endothelial cells: modulation by the peroxisome proliferator-activated receptor-gamma ligand pioglitazone. (15094967)
2004
27
Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. (12724311)
2003
28
Cervical myelomeningocele--follow-up of five patients. (14623220)
2003
29
Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease. (12552460)
2003
30
Contrast-enhanced endosonography for the diagnosis of anal and anovaginal fistulas. (11948570)
2002
31
Systematic review of chorioamnionitis and cerebral palsy. (11921383)
2002
32
Cryptococcal glucuronoxylomannan inhibits adhesion of neutrophils to stimulated endothelium in vitro by affecting both neutrophils and endothelial cells. (12183517)
2002
33
The neuropathology of Aicardi-GoutiA"res syndrome. (12365358)
2002
34
Induction of hypoxia-inducible factor-1alpha and activation of caspase-3 in hypoxia-reoxygenated bone marrow stroma is negatively regulated by the delayed production of substance P. (11591789)
2001
35
The genotype analysis of glucose-6-phosphate dehydrogenase deficiency in Yunnan province]. (11484161)
2001
36
Effects of ovariectomy on intramuscular energy metabolism in young rats: how does sports-related-amenorrhea affect muscles of young female athletes? (11385935)
2001
37
Peritoneal fluid concentrations of interleukin-11 in women with endometriosis. (11119747)
2000
38
Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy. (10587561)
1999
39
Molecular cloning, expression and chromosomal localisation of the mouse Rev3l gene, encoding the catalytic subunit of polymerase zeta. (10102037)
1999
40
Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. (10052460)
1999
41
West Nile fever--a reemerging mosquito-borne viral disease in Europe. (10511520)
1999
42
Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. (9736751)
1998
43
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. (9407028)
1997
44
Genetic analysis of hypophosphatasia. (9316305)
1997
45
Superficial siderosis in the central nervous system. (7760997)
1995
46
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. (8139055)
1994
47
Activities of carbonic anhydrase in the cochleae of guinea pigs with early experimental endolymphatic hydrops. (7972543)
1994
48
cDNA cloning of new protein tyrosine phosphatases in the human colon. (1626183)
1992
49
Thrombotic thrombocytopaenic purpura and anuria: response to plasma exchange. (6929676)
1980
50
Beriberi and other Food-deficiency Diseases in New-foundland and Labrador. (20475070)
1930

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1B, TNF
29.7TNF, TNFRSF1A, TNFRSF1B
39.7TNF, TNFRSF1A, TNFRSF1B
49.7TNF, TNFRSF1A, TNFRSF1B
5
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
6
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
7
Show member pathways
9.7TNF, TNFRSF1A, TNFRSF1B
89.7IL1B, TNF, TNFRSF1A
99.6HLA-DRB1, IL1B, TNF
109.6HLA-DRB1, IL1B, TNF
119.6HLA-DRB1, IL1B, TNF
12
Show member pathways
9.4CRP, IL1B, TNF
139.4IL1B, TNF, TNFRSF1A, TNFRSF1B
149.4HLA-DRB1, IL1B, TNF, TNFRSF1A
15
Show member pathways
9.4HLA-DRB1, IL1B, TNF, TNFRSF1A
16
Show member pathways
9.1HLA-A, HLA-B, IL1B, TNF
17
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
18
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
19
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
20
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
218.9HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF1A
22
Show member pathways
8.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
23
Show member pathways
8.7HLA-A, HLA-B, TNF, TNFRSF10A, TNFRSF10B
24
Show member pathways
8.6HLA-A, HLA-B, TNF, TNFRSF10A, TNFRSF10B
25
Show member pathways
8.5IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
26
Show member pathways
8.3HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF1A
27
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
28
Show member pathways
7.9HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF10A
29
Show member pathways
6.6CRP, ERBB3, HLA-A, HLA-B, HLA-DRB1, IL1B

GO Terms for genes affiliated with Palindromic Rheumatism

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Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IL1B, TNF
3sequestering of triglycerideGO:003073010.5IL1B, TNF
4positive regulation of chemokine biosynthetic processGO:004508010.5IL1B, TNF
5death-inducing signaling complex assemblyGO:007155010.5TNF, TNFRSF1A
6positive regulation of NF-kappaB import into nucleusGO:004234610.5IL1B, TNF
7positive regulation of fever generationGO:003162210.4IL1B, TNF
8negative regulation of lipid catabolic processGO:005099510.4IL1B, TNF
9positive regulation of ceramide biosynthetic processGO:200030410.4TNF, TNFRSF1A
10regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
11protection from natural killer cell mediated cytotoxicityGO:004227010.3HLA-A, HLA-B
12positive regulation of T cell mediated cytotoxicityGO:000191610.3HLA-A, HLA-B
13regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF, TNFRSF1A
14positive regulation of phagocytosisGO:005076610.3IL1B, TNF
15regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.2TNFRSF10A, TNFRSF10B
16establishment of protein localization to plasma membraneGO:009000210.2TNF, TNFRSF1A
17necroptotic processGO:007026610.0TNFRSF10A, TNFRSF10B
18intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.0TNF, TNFRSF1A, TNFRSF1B
19antigen processing and presentationGO:00198829.9HLA-A, HLA-B, HLA-DRB1
20defense response to Gram-positive bacteriumGO:00508309.8CRP, HLA-A, TNF
21negative regulation of neurogenesisGO:00507689.6DYNLT1, IL1B
22cell surface receptor signaling pathwayGO:00071669.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
23extrinsic apoptotic signaling pathwayGO:00971919.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1B
24extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
25response to lipopolysaccharideGO:00324968.9IL1B, PTPN22, TNFRSF10A, TNFRSF10B, TNFRSF1B
26inflammatory responseGO:00069548.8CRP, IL1B, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
27multicellular organism developmentGO:00072758.7TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
28regulation of cell proliferationGO:00421278.5ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.7HLA-A, HLA-B

Sources for Palindromic Rheumatism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet