MCID: PLN005
MIFTS: 43

Palindromic Rheumatism malady

Category: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

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Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 11 48 39 13 68
Hench-Rosenberg Syndrome 11 48
Hench's Syndrome 11 48
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 48
Palindromic Rheumatism Syndrome 48

Classifications:



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Disease Ontology11 DOID:1166
ICD1030 M12.3, M12.30
MeSH39 C538103

Summaries for Palindromic Rheumatism

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NIH Rare Diseases:48 Palindromic rheumatism (PR) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. Each episode may last from several hours to several days. The frequency of attacks also varies, from one episode a day to several during the course of a year. Between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. The cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. There may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. Some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. Treatment may include nonsteroidal anti-inflammatory drugs (NSAIDs) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. Last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and systemic lupus erythematosus, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways are LDL Oxidation in Atherogenesis and Rheumatoid arthritis. Affiliated tissues include neutrophil, lung and heart, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and neoplasm.

Disease Ontology:11 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:71 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.8CRP, HLA-DRB1, IL1B, PADI4, PRTN3, PTPN22
2systemic lupus erythematosus28.8CRP, HLA-DRB1, PRTN3, PTPN22, TNF, TNFRSF1B
3autosomal recessive secondary polycythemia not associated with vhl gene10.7MEFV, TNFRSF1A
4adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency10.7MEFV, TNFRSF1A
5thyroid malformation10.6IL1B, TNF
6hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.6IL1B, TNF
7progressive locomotor ataxia10.6HLA-A, HLA-DRB1
8stomatocytosis ii10.6MEFV, TNF
9common variable immunodeficiency10.6HLA-DRB1, TNF
10pure mitochondrial myopathy10.6MEFV, TNFRSF1A
11parsonage turner syndrome10.6HLA-DRB1, TNF
12weber syndrome10.6HLA-DRB1, TNF
13baetz-greenwalt syndrome10.5IL1B, TNF
14myopathy-growth delay-intellectual disability-hypospadias syndrome10.5HLA-DRB1, TNF
15pulmonary hypertension10.5IL1B, TNF
16krieble bixler syndrome10.5HLA-DRB1, TNF
17familial cold-induced inflammatory syndrome 110.5IL1B, MEFV, TNFRSF1A
18abdominal chemodectomas with cutaneous angiolipomas10.5HLA-DRB1, PTPN22, TNF
19cinca syndrome10.5IL1B, MEFV, TNFRSF1A
20uveoparotid fever10.5TNF, TNFRSF1B
21brain stem cancer10.5TNF, TNFRSF1B
22multiple sclerosis 510.5MEFV, TNF, TNFRSF1A
23spastic paraplegia-paget disease of bone syndrome10.5HLA-DRB1, IL1B, TNF
24meier-gorlin syndrome 310.5IL1B, MEFV, TNF
25retroperitoneal fibrosis10.5HLA-DRB1, IL1B, TNF
26hereditary conventional renal cell carcinoma10.5HLA-DRB1, PTPN22, TNF
27cerebral atherosclerosis10.4TNF, TNFRSF1A, TNFRSF1B
28scrotum paget's disease10.4IL1B, TNF
29stone in bladder diverticulum10.4TNF, TNFRSF1B
30arthritis10.4
31fetal erythroblastosis10.4TNF, TNFRSF1A, TNFRSF1B
32salpingitis10.4TNF, TNFRSF1A, TNFRSF1B
33siderosis10.4HLA-A, TNFRSF10A
34neuromuscular disease10.4TNF, TNFRSF1B
35adult malignant hemangiopericytoma10.4HLA-DRB1, IL1B, TNF
36conjunctival pigmentation10.4HLA-A, HLA-DRB1, PTPN22
37night blindness10.4TNF, TNFRSF1B
38babesiosis10.4IL1B, MEFV, TNF
39lethal midline granuloma10.4HLA-DRB1, IL1B, TNF
40panner disease10.4CRP, TNF
41lipodermatosclerosis10.4HLA-A, HLA-DRB1, TNF
42potato nose10.4HLA-A, HLA-DRB1, TNF
43arachnoiditis10.4HLA-A, HLA-DRB1, TNF
44uterine inversion10.4IL1B, TNF, TNFRSF1A
45sensorineural hearing loss10.4HLA-A, HLA-DRB1, TNF
46hemophagocytic lymphohistiocytosis10.4HLA-A, HLA-DRB1, TNF
47central gyrate choroidal dystrophy10.4CRP, HLA-DRB1, MEFV
48warm antibody hemolytic anemia10.4IL1B, TNF
49antigen-peptide-transporter 2 deficiency10.4HLA-A, PTPN22, TNF
50foster-kennedy syndrome10.4HLA-A, HLA-DRB1, TNFRSF10B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

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UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

MGI Mouse Phenotypes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF1A, TNFRSF1B
2MP:00053978.0IL1B, LAIR1, MEFV, PADI4, PRTN3, PTPN22
3MP:00053877.0CRP, ERBB3, IL1B, LAIR1, MEFV, PADI4

Drugs & Therapeutics for Palindromic Rheumatism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

36
Neutrophil, Lung, Heart

Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. (26235245)
2015
2
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. (26457478)
2015
3
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
4
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
5
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
6
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
7
Palindromic rheumatism: a pre-rheumatoid arthritis state? (23028026)
2012
8
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
9
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
10
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. (22536266)
2012
11
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. (22898224)
2012
12
Palindromic rheumatism. (21206416)
2011
13
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
14
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
15
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. (20476860)
2010
16
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. (19648311)
2009
17
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. (19710217)
2009
18
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
19
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
20
Magnetic resonance imaging of palindromic rheumatism. (18663450)
2008
21
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
22
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
23
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
24
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
25
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. (17187097)
2006
26
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. (16724377)
2006
27
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. (16847371)
2006
28
Short term palindromic rheumatism after clopidogrel use. (16611878)
2006
29
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. (16189657)
2005
30
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
31
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. (15290752)
2004
32
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? (12730510)
2003
33
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. (12415587)
2002
34
Palindromic rheumatism. (12408287)
2002
35
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. (24387063)
2002
36
A patient with severe palindromic rheumatism and frequent episodes of pain. (11300148)
2001
37
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. (10648016)
2000
38
Palindromic rheumatism: effect of dietary manipulation. (10895376)
2000
39
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
40
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
41
Sparing effect of hemiparesis on palindromic rheumatism. (9093804)
1997
42
Remission in palindromic rheumatism during pregnancy. (8478889)
1993
43
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
44
Palindromic rheumatism: part of or apart from the spectrum of rheumatoid arthritis. (1341421)
1992
45
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
46
Palindromic rheumatism: a response to chloroquine. (2023196)
1991
47
Coexistent Felty's syndrome and palindromic rheumatism. (1768169)
1991
48
Palindromic rheumatism: a case history. (2396876)
1990
49
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
50
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1B, TNF
29.7HLA-DRB1, IL1B, TNF
39.7HLA-DRB1, IL1B, TNF
49.7HLA-DRB1, IL1B, TNF
59.7IL1B, TNF, TNFRSF1A
69.6TNF, TNFRSF1A, TNFRSF1B
7
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
89.6TNF, TNFRSF1A, TNFRSF1B
9
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
10
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
119.6TNF, TNFRSF1A, TNFRSF1B
12
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
13
Show member pathways
9.6HLA-A, HLA-DRB1, IL1B
149.4HLA-DRB1, IL1B, TNF, TNFRSF1A
15
Show member pathways
9.4HLA-DRB1, IL1B, TNF, TNFRSF1A
169.4IL1B, TNF, TNFRSF1A, TNFRSF1B
179.3HLA-A, HLA-DRB1, TNF, TNFRSF1A
189.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
19
Show member pathways
9.1HLA-A, TNF, TNFRSF10A, TNFRSF10B
20
Show member pathways
9.0IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
21
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
22
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
238.8IL1B, PTPN22, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
24
Show member pathways
8.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
25
Show member pathways
8.6HLA-A, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26
Show member pathways
8.5IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
27
Show member pathways
8.4HLA-A, HLA-DRB1, IL1B, TNF, TNFRSF10A, TNFRSF10B
28
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
29
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
30
Show member pathways
6.4CRP, ERBB3, HLA-A, HLA-DRB1, IL1B, LAIR1

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.4HLA-A, HLA-DRB1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
2plasma membraneGO:00058866.3ERBB3, HLA-A, HLA-DRB1, LAIR1, MRAP, PRTN3

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complex assemblyGO:007155010.7TNF, TNFRSF1A
2chronic inflammatory response to antigenic stimulusGO:000243910.7IL1B, TNF
3positive regulation of ceramide biosynthetic processGO:200030410.6TNF, TNFRSF1A
4negative regulation of lipid catabolic processGO:005099510.6IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
7positive regulation of fever generationGO:003162210.6IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.6IL1B, TNF
9activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.6TNFRSF10A, TNFRSF10B
10regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.5IL1B, TNF
11sequestering of triglycerideGO:003073010.4IL1B, TNF
12negative regulation of inflammatory responseGO:005072810.4MEFV, TNFRSF1A, TNFRSF1B
13negative regulation of lipid storageGO:001088810.4CRP, TNF
14regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.4TNFRSF10A, TNFRSF10B
15lipopolysaccharide-mediated signaling pathwayGO:003166310.4IL1B, PTPN22, TNF
16intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.4TNF, TNFRSF1A, TNFRSF1B
17positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IL1B, TNF, TNFRSF1B
18extrinsic apoptotic signaling pathwayGO:009719110.3TNF, TNFRSF10A, TNFRSF1B
19regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF, TNFRSF1A
20activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.3TNF, TNFRSF10A, TNFRSF10B
21cellular response to mechanical stimulusGO:007126010.0IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A
22cell surface receptor signaling pathwayGO:000716610.0TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
23positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.0IL1B, TNF, TNFRSF10B, TNFRSF1A
24extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
25regulation of apoptotic processGO:00429819.9TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26positive regulation of gene expressionGO:00106289.4CRP, ERBB3, IL1B, PTPN22, TNF
27response to lipopolysaccharideGO:00324969.3IL1B, PTPN22, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
28regulation of cell proliferationGO:00421279.1ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
29tumor necrosis factor-mediated signaling pathwayGO:00332099.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
30inflammatory responseGO:00069548.8CRP, IL1B, MEFV, TNF, TNFRSF10A, TNFRSF10B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TRAIL bindingGO:004556910.2TNFRSF10A, TNFRSF10B
2tumor necrosis factor-activated receptor activityGO:00050319.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Sources for Palindromic Rheumatism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet