MCID: PLN005
MIFTS: 53

Palindromic Rheumatism malady

Rare diseases category
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Summaries for Palindromic Rheumatism

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NIH Rare Diseases:42 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and arthritis. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean fever), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Inflammatory Response Pathway. The compounds tumour necrosis factor membrane form and lymphotoxin-alpha have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and neutrophil, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:8 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:65 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Aliases & Classifications for Palindromic Rheumatism

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Palindromic Rheumatism, Aliases & Descriptions:

Name: Palindromic Rheumatism 8 42 10 62
Hench-Rosenberg Syndrome 8 42 62
Palindromic Rheumatism Syndrome 42 62
 
Hench's Syndrome 8 42
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


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Disease Ontology8 DOID:1166
ICD9CM27 719.30, 719.3
MeSH34 C538103
ICD1025 M12.3

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis31.3PADI4, PTPN22, HLA-DRB1
2arthritis31.0TNF, TNFRSF1A, IL1B
3polyarteritis nodosa31.0MEFV
4connective tissue disease30.5PTPN22, TNF, HLA-DRB1
5familial mediterranean fever30.4TNF, TNFRSF1A, MEFV
6synovitis30.2TNFRSF1B, TNF, TNFRSF1A, IL1B
7systemic lupus erythematosus29.4HLA-DRB1, TNFRSF1B, TNF, TNFRSF1A, PTPN22, PADI4
8pericarditis10.5MEFV
9erysipelas10.5MEFV
10adult-onset still's disease10.5TNFRSF1B
11leishmaniasis10.4TNFRSF1A
12vogt-koyanagi-harada disease10.4HLA-DRB1
13felty's syndrome10.3
14leprosy10.3HLA-DRB1
15degenerative disc disease10.3IL1B
16relapsing fever10.3MEFV, TNFRSF1A
17abdominal aortic aneurysm10.2TNFRSF1B, TNFRSF1A
18lymphopenia10.2PTPN22, TNFRSF1B
19ankylosing spondylitis10.2TNFRSF1B, TNF
20myocardial infarction10.2
21antiphospholipid syndrome10.2
22primary hypertrophic osteoarthropathy10.2
23dermatitis10.2
24lupus erythematosus10.2
25psoriatic arthritis10.2TNF, TNFRSF1B
26thyroiditis10.2HLA-DRB1, PTPN22
27malaria10.2TNF, HLA-DRB1
28narcolepsy10.1TNFRSF1B, HLA-DRB1
29amyloidosis10.1TNFRSF1A, MEFV
30pleurisy10.1IL1B, MEFV
31crohn's disease10.1TNF, TNFRSF1B
32behcet's disease10.1MEFV, TNF, TNFRSF1B
33vasculitis10.1MEFV, TNF, TNFRSF1B
34periodic fever, familial, autosomal dominant10.1TNF, TNFRSF1A, MEFV
35viral hepatitis10.1TNFRSF1A, HLA-DRB1
36aids dementia complex10.1IL1B, TNF
37chorioamnionitis10.1IL1B, TNF
38interstitial lung disease10.0TNF, IL1B
39hyperthyroidism10.0PTPN22, HLA-DRB1
40cholangiocarcinoma10.0TNFRSF1A, TNFRSF1B
41cerebral malaria10.0IL1B, TNF
42skin disease10.0HLA-DRB1, IL1B
43toxic shock syndrome10.0TNF, IL1B
44hepatitis10.0TNFRSF1A, HLA-DRB1
45adult respiratory distress syndrome10.0TNF, IL1B
46uveitis10.0TNFRSF1A, TNF, TNFRSF1B
47respiratory failure10.0IL1B, TNF
48periodontitis10.0IL1B, TNF
49juvenile rheumatoid arthritis10.0HLA-DRB1, TNFRSF1B, TNF
50schizophrenia10.0TNFRSF1A, TNFRSF1B, HLA-DRB1

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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Drug clinical trials:

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Search NIH Clinical Center for Palindromic Rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

32
Heart, Lung, Neutrophil

Animal Models for Palindromic Rheumatism or affiliated genes

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Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
2
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
3
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
4
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
5
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
6
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
7
Palindromic rheumatism. (21206416)
2011
8
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
9
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
10
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
11
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
12
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
13
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
14
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
15
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
16
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
17
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
18
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
19
Palindromic rheumatism: a case history. (2396876)
1990
20
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
21
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988
22
Sulphasalazine for palindromic rheumatism. (2892559)
1988
23
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
24
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
25
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
26
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
27
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
28
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
29
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
30
Palindromic rheumatism: a review. (7021825)
1981
31
Palindromic rheumatism. (1086697)
1976
32
Letter: Palindromic rheumatism. (4548064)
1974
33
Letter: Palindromic rheumatism. (4830920)
1974
34
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
35
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
36
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
37
Palindromic rheumatism. (5296469)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
A case of palindromic rheumatism. (13992037)
1962
40
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14799163)
1951
44
Palindromic rheumatism. (14806892)
1950
45
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
46
Palindromic Rheumatism. (18623788)
1948
47
Palindromic rheumatism. (20264810)
1947
48
Palindromic rheumatism in children. (21019385)
1946
49
Palindromic Rheumatism. (20786547)
1946
50
Palindromic rheumatism. (21004709)
1945

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Expression patterns in normal tissues for genes affiliated with Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFRSF1B, TNFRSF1A
29.5TNFRSF1A, TNFRSF1B
39.4TNF, TNFRSF1A
4
Show member pathways
9.4TNFRSF1A, TNF
5
Show member pathways
9.4TNFRSF1A, TNF
69.1IL1B, TNF
79.1IL1B, TNF
89.1IL1B, TNF
99.1IL1B, TNF
109.1TNF, IL1B
11
Show member pathways
Serotonin Transporter Activity37
9.1IL1B, TNF
12
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0TNFRSF1B, TNFRSF1A, TNF
13
Show member pathways
Alternative NF-kappaB pathway37
9.0TNFRSF1B, TNF, TNFRSF1A
14
Show member pathways
9.0TNFRSF1A, TNFRSF1B, TNF
15
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0TNFRSF1A, TNF, TNFRSF1B
169.0TNF, TNFRSF1B, TNFRSF1A
17
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0TNF, TNFRSF1B, TNFRSF1A
18
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.0TNFRSF1B, TNFRSF1A, TNF
19
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.0TNFRSF1B, TNF, TNFRSF1A
20
Show member pathways
9.0TNFRSF1B, TNF, TNFRSF1A
21
Show member pathways
9.0TNFRSF1B, TNFRSF1A, TNF
229.0TNFRSF1A, TNFRSF1B, TNF
23
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.0TNFRSF1A, TNFRSF1B, TNF
24
Show member pathways
9.0TNF, TNFRSF1B, TNFRSF1A
258.8TNFRSF1A, HLA-DRB1, TNF
26
Show member pathways
8.8MEFV, IL1B, TNF
27
Show member pathways
Alzheimers Disease37
8.6TNFRSF1A, IL1B, TNF
28
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6TNF, IL1B, TNFRSF1A
29
Show member pathways
8.6TNFRSF1A, TNF, IL1B
30
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.6TNF, TNFRSF1A, IL1B
31
Show member pathways
MAPK signaling pathway37
8.6TNF, TNFRSF1A, IL1B
328.6TNF, TNFRSF1A, IL1B
338.6TNFRSF1A, TNF, IL1B
348.5TNF, HLA-DRB1, IL1B
358.5TNF, IL1B, HLA-DRB1
368.5HLA-DRB1, TNF, IL1B
37
Show member pathways
8.2IL1B, TNF, TNFRSF1B, TNFRSF1A
388.2TNFRSF1B, TNF, TNFRSF1A, IL1B
39
Show member pathways
8.2TNFRSF1A, TNF, TNFRSF1B, IL1B
40
Show member pathways
8.2TNFRSF1B, TNF, TNFRSF1A, IL1B
41
Show member pathways
8.2TNFRSF1B, TNF, IL1B, TNFRSF1A
42
Show member pathways
8.2TNFRSF1A, TNF, TNFRSF1B, IL1B
438.2TNFRSF1A, IL1B, TNF, TNFRSF1B
44
Show member pathways
8.2TNF, TNFRSF1A, IL1B, TNFRSF1B
45
Show member pathways
8.0TNF, HLA-DRB1, IL1B, TNFRSF1A
46
Show member pathways
8.0IL1B, TNF, HLA-DRB1, TNFRSF1A
478.0HLA-DRB1, TNF, TNFRSF1A, IL1B
48
Show member pathways
8.0HLA-DRB1, TNF, TNFRSF1A, IL1B
49
Show member pathways
7.7TNF, IL1B, PTPN22, TNFRSF1A, TNFRSF1B
50
Show member pathways
7.5HLA-DRB1, TNFRSF1A, TNF, TNFRSF1B, IL1B

Compounds for genes affiliated with Palindromic Rheumatism

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Compounds related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1tumour necrosis factor membrane form289.9TNFRSF1A, TNFRSF1B
2lymphotoxin-alpha289.9TNFRSF1B, TNFRSF1A
3bcma449.7TNFRSF1A, TNF
4blys449.7TNFRSF1A, TNF
5tab-1449.6TNFRSF1A, TNF
6n,n-dimethylsphingosine44 6110.5TNF, IL1B
7tenidap44 2810.5TNF, IL1B
8anakinra44 1110.5TNF, IL1B
9cicaprost44 2810.5TNF, IL1B
10taurine chloramine449.4TNF, IL1B
11vesnarinone449.4IL1B, TNF
12toxin-1449.4TNF, IL1B
13manganese superoxide449.4TNFRSF1A, TNFRSF1B, TNF
14chloroquine44 2 50 28 1113.4TNF, TNFRSF1A, TNFRSF1B
15mip 1alpha449.4IL1B, TNF
16ceramide449.2TNF, TNFRSF1B, TNFRSF1A
17ro 31 8220449.1TNF, IL1B
18nash449.1TNF, TNFRSF1A
19cuprophan449.1IL1B, TNFRSF1A, TNFRSF1B
20il 10449.1IL1B, TNFRSF1B, TNF
21actinomycin449.0TNFRSF1A, IL1B, TNF
22leflunomide44 50 1111.0TNF, TNFRSF1A, IL1B
23ns 39844 6110.0TNF, IL1B, TNFRSF1A
24c2ceramide449.0IL1B, TNF, TNFRSF1A
25anisomycin44 1110.0TNF, IL1B, TNFRSF1A
26sp 60012544 6110.0TNFRSF1A, TNF, IL1B
27tgf beta1449.0TNFRSF1A, TNF, IL1B
28gold sodium thiomalate448.9TNF, HLA-DRB1, IL1B
29herbimycin a44 619.9IL1B, TNFRSF1A, TNF
30prostacyclin448.9TNF, IL1B, TNFRSF1A
31calcitriol44 61 24 1111.8TNF, IL1B, TNFRSF1A
32etanercept44 50 1110.6TNFRSF1B, TNFRSF1A, IL1B, TNF
33infliximab44 50 1110.6TNF, TNFRSF1B, IL1B, TNFRSF1A
34ivig448.6IL1B, TNFRSF1B, TNF, TNFRSF1A
35neopterin448.6TNFRSF1A, IL1B, TNF, TNFRSF1B
36thalidomide44 50 61 1111.6IL1B, TNFRSF1A, TNFRSF1B, TNF
37curcumin448.6TNFRSF1B, IL1B, TNF, TNFRSF1A
38fmlp448.6TNFRSF1A, IL1B, TNF, TNFRSF1B
39rantes448.6IL1B, TNFRSF1A, TNF, TNFRSF1B
40actinomycin d448.5IL1B, TNFRSF1A, TNF, TNFRSF1B
41pge2448.5TNFRSF1B, TNFRSF1A, TNF, IL1B
42superoxide44 249.5TNFRSF1B, TNFRSF1A, IL1B, TNF
43cycloheximide448.5IL1B, TNFRSF1B, TNFRSF1A, TNF
44arginine448.5PADI4, HLA-DRB1, TNFRSF1B, PTPN22
45dexamethasone44 50 28 1111.4TNFRSF1A, TNF, IL1B, TNFRSF1B
46endotoxin448.3MEFV, TNF, TNFRSF1A, TNFRSF1B, IL1B
47tyrosine448.2TNFRSF1B, MEFV, HLA-DRB1, TNFRSF1A, PTPN22
48vegf448.2IL1B, TNFRSF1A, TNF, TNFRSF1B
49nitric oxide44 24 1110.2TNF, TNFRSF1A, TNFRSF1B, IL1B
50methotrexate50 44 1110.0IL1B, TNFRSF1A, TNF, HLA-DRB1, TNFRSF1B

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.7TNFRSF1A, TNF, TNFRSF1B
2extracellular regionGO:0055768.2IL1B, TNFRSF1A, TNF, TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-6 productionGO:0327159.7TNF, TNFRSF1A
2extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.6TNF, TNFRSF1A
3negative regulation of inflammatory responseGO:0507289.5TNFRSF1B, TNFRSF1A, MEFV
4sequestering of triglycerideGO:0307309.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, TNF
6positive regulation of fever generationGO:0316229.5IL1B, TNF
7positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:0450809.5IL1B, TNF
9regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.5TNF, IL1B
10negative regulation of lipid catabolic processGO:0509959.5IL1B, TNF
11positive regulation of NF-kappaB import into nucleusGO:0423469.4IL1B, TNF
12negative regulation of gene expressionGO:0106299.4TNFRSF1A, TNF
13lipopolysaccharide-mediated signaling pathwayGO:0316639.4TNF, IL1B
14positive regulation of mitosisGO:0458409.4IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, IL1B
16protein kinase B signalingGO:0434919.4TNF, IL1B
17intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.4TNFRSF1B, TNF, TNFRSF1A
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.4IL1B, TNF
19cellular response to organic cyclic compoundGO:0714079.3IL1B, TNF
20positive regulation of interferon-gamma productionGO:0327299.3IL1B, TNF
21positive regulation of interleukin-6 productionGO:0327559.2IL1B, TNF
22positive regulation of JNK cascadeGO:0463309.1TNF, IL1B
23positive regulation of membrane protein ectodomain proteolysisGO:0510449.1IL1B, TNF, TNFRSF1B
24cellular response to mechanical stimulusGO:0712609.0IL1B, TNFRSF1A
25positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.9IL1B, TNFRSF1A, TNF
26MAPK cascadeGO:0001658.8IL1B, TNF
27cytokine-mediated signaling pathwayGO:0192218.8IL1B, TNFRSF1A, HLA-DRB1
28immune responseGO:0069558.6IL1B, TNFRSF1B, HLA-DRB1
29inflammatory responseGO:0069548.2IL1B, MEFV, TNFRSF1A, TNF, TNFRSF1B

Molecular functions related to Palindromic Rheumatism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4TNFRSF1A, TNF
2tumor necrosis factor-activated receptor activityGO:0050319.2TNFRSF1A, TNFRSF1B

Products for genes affiliated with Palindromic Rheumatism

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Sources for Palindromic Rheumatism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet