MCID: PLN005
MIFTS: 40

Palindromic Rheumatism malady

Rare diseases category

Aliases & Classifications for Palindromic Rheumatism

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Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 10 45 12 65 36
Hench-Rosenberg Syndrome 10 45
Hench's Syndrome 10 45
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 45
Palindromic Rheumatism Syndrome 45


Classifications:



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Disease Ontology10 DOID:1166
MeSH36 C538103
ICD9CM29 719.3, 719.30
ICD1027 M12.3

Summaries for Palindromic Rheumatism

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NIH Rare Diseases:45 Palindromic rheumatism (pr) is characterized by sudden, multiple, and recurring attacks of joint pain and swelling, typically in the hands and feet. each episode may last from several hours to several days. the frequency of attacks also varies, from one episode a day to several during the course of a year. between attacks, the symptoms disappear and the affected joints appear normal on x-ray exams. the cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested. there may also be a clinical association between antiphospholipid syndrome and palindromic rheumatism. some individuals with palindromic rheumatism develop chronic joint inflammation and go on to develop rheumatoid arthritis. treatment may include nonsteroidal anti-inflammatory drugs (nsaids) for acute attacks and antimalarials, which have been helpful in reducing the frequency and duration of attacks and may reduce to likelihood that palindromic rheumatism will progress to rheumatoid arthritis. last updated: 10/3/2013

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and systemic lupus erythematosus. An important gene associated with Palindromic Rheumatism is MEFV (Mediterranean Fever), and among its related pathways are Cellular Transformation by HTLV1 and Transcription_NF-kB signaling pathway. Affiliated tissues include neutrophil, lung and heart, and related mouse phenotypes are tumorigenesis and mortality/aging.

Disease Ontology:10 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia:68 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis30.4CRP, HLA-B, HLA-DRB1, IL1B, PADI4, PRTN3
2systemic lupus erythematosus30.0CRP, HLA-DRB1, PRTN3, PTPN22, TNF, TNFRSF1B
3arthritis10.9
4synovitis10.4
5felty's syndrome10.4
6connective tissue disease10.4
7neonatal intrahepatic cholestasis due to citrin deficiency10.3MEFV, TNFRSF1A
8non-immunoglobulin-mediated membranoproliferative glomerulonephritis10.3MEFV, TNFRSF1A
9meckel's diverticulitis10.3IL1B, TNF
10periodic fever, familial10.3MEFV, TNF, TNFRSF1A
11cinca syndrome10.3IL1B, MEFV, TNFRSF1A
12stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IL1B, TNF
13muckle-wells syndrome10.3IL1B, MEFV, TNFRSF1A
14familial colorectal cancer10.3IL1B, MEFV, TNFRSF1A
15lethal infantile mitochondrial myopathy10.3MEFV, TNFRSF1A
16bullous retinoschisis10.3TNF, TNFRSF1B
17peyronie's disease10.3IL1B, TNF
18best1 retinopathy10.3HLA-DRB1, TNF
19congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.3HLA-DRB1, IL1B, TNF
20cerebral atherosclerosis10.3TNF, TNFRSF1A, TNFRSF1B
21microsomia hemifacial radial defects10.2HLA-DRB1, TNF
22sarcomatoid squamous cell skin carcinoma10.2TNF, TNFRSF1B
23acute sanguinous otitis media10.2TNF, TNFRSF1A, TNFRSF1B
24ciliopathy10.2TNF, TNFRSF1A, TNFRSF1B
25sarcoidosis, early-onset10.2IL1B, MEFV, TNF
26idiopathic spinal cord herniation10.2HLA-DRB1, IL1B, TNF
27cervical adenocarcinoma10.2CRP, IL1B, MEFV
28jaccoud's syndrome10.2HLA-A, HLA-B
29gum cancer10.2TNF, TNFRSF1A, TNFRSF1B
30anti-hla hyperimmunization10.2HLA-B, PTPN22, TNF
31postinfectious encephalomyelitis10.2HLA-A, HLA-B, HLA-DRB1
32myocardial infarction10.2
33primary hypertrophic osteoarthropathy10.2
34antiphospholipid syndrome10.2
35polyarteritis nodosa10.2
36dermatitis10.2
37lupus erythematosus10.2
38childhood cerebellar astrocytic neoplasm10.2HLA-A, HLA-B, HLA-DRB1
39xanthogranulomatous pyelonephritis10.2HLA-A, HLA-B, HLA-DRB1
40ectropion10.2HLA-B, HLA-DRB1, TNF
41plantar nerve lesion10.2IL1B, TNF
42cerebellar astrocytoma10.2CRP, HLA-DRB1, TNFRSF10A
43osmotic diarrhea10.2HLA-A, IL1B, TNF
44hordeolum10.2HLA-A, HLA-B, HLA-DRB1
45vagus nerve neoplasm10.2HLA-A, HLA-B, MEFV
46bartholin's duct cyst10.2CRP, HLA-DRB1, TNF
47pulmonary nodular lymphoid hyperplasia10.2HLA-A, HLA-B, HLA-DRB1
48pneumoconiosis10.2CRP, MEFV, TNF
49cellular myxoid liposarcoma10.2TNF, TNFRSF1B
50hemorrhoid10.2CRP, HLA-DRB1, TNF

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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Drugs & Therapeutics for Palindromic Rheumatism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: Palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

33
Neutrophil, Lung, Heart

Animal Models for Palindromic Rheumatism or affiliated genes

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MGI Mouse Phenotypes related to Palindromic Rheumatism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ERBB3, IL1B, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
2MP:00107686.8ERBB3, HBA2, HBB, HLA-B, IL1B, MEFV
3MP:00053766.8CRP, ERBB3, HBA2, HBB, IL1B, MEFV
4MP:00053976.6HBA2, HBB, HLA-B, IL1B, MEFV, PADI4
5MP:00053876.0CRP, ERBB3, HBB, HLA-B, IL1B, MEFV

Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
2
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
3
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
4
Palindromic rheumatism: consider Whipple's disease. (23992271)
2013
5
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. (22859345)
2012
6
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. (22665157)
2012
7
Palindromic rheumatism. (21206416)
2011
8
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. (19771490)
2010
9
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
10
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
11
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. (17665427)
2007
12
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
13
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? (18290263)
2007
14
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
15
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
16
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
17
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
18
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. (1629832)
1992
19
Palindromic rheumatism: a case history. (2396876)
1990
20
Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients. (2612120)
1989
21
HLA antigens in palindromic rheumatism. An Italian study. (3266740)
1988
22
Sulphasalazine for palindromic rheumatism. (2892559)
1988
23
Treatment of palindromic rheumatism with chloroquine. (3109620)
1987
24
Treatment of palindromic rheumatism with chloroquine. (3105719)
1987
25
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
26
HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheumatoid arthritis. (6610047)
1984
27
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
28
Prophylactic colchicine therapy in palindromic rheumatism. (6980282)
1982
29
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
30
Palindromic rheumatism: a review. (7021825)
1981
31
Palindromic rheumatism. (1086697)
1976
32
Letter: Palindromic rheumatism. (4548064)
1974
33
Letter: Palindromic rheumatism. (4830920)
1974
34
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
35
Letters to the editor. Additional data: palindromic rheumatism caused by sodium nitrate. (5317285)
1970
36
Palindromic rheumatism: case report with response to indomethacin. (5304598)
1969
37
Palindromic rheumatism. (5296469)
1966
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
A case of palindromic rheumatism. (13992037)
1962
40
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
41
Psychosomatic study of a case of palindromic rheumatism. (13233967)
1954
42
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
43
Palindromic rheumatism. (14799163)
1951
44
Palindromic rheumatism. (14806892)
1950
45
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
46
Palindromic Rheumatism. (18623788)
1948
47
Palindromic rheumatism. (20264810)
1947
48
Palindromic rheumatism in children. (21019385)
1946
49
Palindromic Rheumatism. (20786547)
1946
50
Palindromic rheumatism. (21004709)
1945

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8TNF, TNFRSF1A, TNFRSF1B
29.8TNF, TNFRSF1A, TNFRSF1B
39.8TNF, TNFRSF1A, TNFRSF1B
4
Show member pathways
9.8TNF, TNFRSF1A, TNFRSF1B
5
Show member pathways
9.8TNF, TNFRSF1A, TNFRSF1B
69.8TNF, TNFRSF1A, TNFRSF1B
79.7IL1B, TNF, TNFRSF1A
89.7HLA-DRB1, IL1B, TNF
99.7HLA-DRB1, IL1B, TNF
109.7HLA-DRB1, IL1B, TNF
119.5IL1B, TNF, TNFRSF1A, TNFRSF1B
129.5HLA-DRB1, IL1B, TNF, TNFRSF1A
13
Show member pathways
9.5HLA-DRB1, IL1B, TNF, TNFRSF1A
149.5TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
15
Show member pathways
9.3HLA-A, HLA-B, IL1B, TNF
16
Show member pathways
9.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
17
Apoptosis (WikiPathways)
Show member pathways
9.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
18
Show member pathways
9.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
19
TNF signaling (REACTOME)
Show member pathways
9.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
20
Apoptosis (KEGG)
Show member pathways
9.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
219.1HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF1A
229.0IL1B, PTPN22, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
23
Show member pathways
9.0HLA-A, HLA-B, TNF, TNFRSF10A, TNFRSF10B
24
Show member pathways
8.9IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
25
TNF Signaling (sino)
Show member pathways
8.9IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
268.8HBA2, HBB, IL1B, TNF
278.8HBA2, HBB, IL1B, TNF
28
Show member pathways
8.7IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
29
Show member pathways
8.6HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF1A
30
Show member pathways
8.4CRP, HBA2, HBB, IL1B, TNF
31
Show member pathways
8.2HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF10A
32
Show member pathways
7.6CRP, ERBB3, HLA-A, HLA-B, HLA-DRB1, IL1B

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:004261210.5HLA-A, HLA-B
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.0HLA-A, HLA-B, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:001250710.0HLA-A, HLA-B, HLA-DRB1
4haptoglobin-hemoglobin complexGO:003183810.0HBA2, HBB
5hemoglobin complexGO:000583310.0HBA2, HBB
6cell surfaceGO:00099868.5HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF10A, TNFRSF10B
7integral component of plasma membraneGO:00058877.6ERBB3, HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF10A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complex assemblyGO:007155010.7TNF, TNFRSF1A
2positive regulation of CD8-positive, alpha-beta T cell proliferationGO:200056610.7HLA-A, PTPN22
3sequestering of triglycerideGO:003073010.7IL1B, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:006055910.7IL1B, TNF
5chronic inflammatory response to antigenic stimulusGO:000243910.6IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
7negative regulation of lipid catabolic processGO:005099510.6IL1B, TNF
8positive regulation of heterotypic cell-cell adhesionGO:003411610.6IL1B, TNF
9positive regulation of fever generationGO:003162210.5IL1B, TNF
10negative regulation of lipid storageGO:001088810.5CRP, TNF
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.5HLA-A, HLA-B
12antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:000248610.5HLA-A, HLA-B
13positive regulation of T cell mediated cytotoxicityGO:000191610.5HLA-A, HLA-B
14protection from natural killer cell mediated cytotoxicityGO:004227010.5HLA-A, HLA-B
15regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.5IL1B, TNF
16positive regulation of ceramide biosynthetic processGO:200030410.4TNF, TNFRSF1A
17regulation of establishment of endothelial barrierGO:190314010.4IL1B, TNF, TNFRSF1A
18positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IL1B, TNF, TNFRSF1B
19negative regulation of inflammatory responseGO:005072810.4MEFV, TNFRSF1A, TNFRSF1B
20lipopolysaccharide-mediated signaling pathwayGO:003166310.3IL1B, PTPN22, TNF
21intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.3TNF, TNFRSF1A, TNFRSF1B
22positive regulation of interferon-gamma productionGO:003272910.2HLA-A, IL1B, TNF
23detection of bacteriumGO:001604510.2HLA-A, HLA-B, HLA-DRB1
24interferon-gamma-mediated signaling pathwayGO:006033310.2HLA-A, HLA-B, HLA-DRB1
25antigen processing and presentationGO:001988210.1HLA-A, HLA-B, HLA-DRB1
26activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.1TNF, TNFRSF10A, TNFRSF10B
27extrinsic apoptotic signaling pathwayGO:009719110.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1B
28extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
29defense responseGO:000695210.0HLA-B, TNF, TNFRSF1A
30positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.9IL1B, TNF, TNFRSF10B, TNFRSF1A
31defense response to Gram-positive bacteriumGO:00508309.8CRP, HLA-A, TNF
32cellular response to mechanical stimulusGO:00712609.8IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A
33tumor necrosis factor-mediated signaling pathwayGO:00332099.7TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
34response to lipopolysaccharideGO:00324969.6IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
35positive regulation of nitric oxide biosynthetic processGO:00454299.6HBB, IL1B, TNF
36cell surface receptor signaling pathwayGO:00071669.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
37multicellular organismal developmentGO:00072759.2TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
38positive regulation of cell deathGO:00109429.1HBA2, HBB, IL1B
39regulation of cell proliferationGO:00421278.9ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
40cytokine-mediated signaling pathwayGO:00192218.8HLA-A, HLA-B, HLA-DRB1, IL1B, TNFRSF1A
41inflammatory responseGO:00069548.7CRP, IL1B, MEFV, TNF, TNFRSF10A, TNFRSF10B
42immune responseGO:00069558.3HLA-A, HLA-B, HLA-DRB1, IL1B, TNF, TNFRSF10A

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TRAIL bindingGO:004556910.1TNFRSF10A, TNFRSF10B
2TAP bindingGO:004697710.1HLA-A, HLA-B
3oxygen transporter activityGO:00053449.7HBA2, HBB
4haptoglobin bindingGO:00317209.7HBA2, HBB
5peptide antigen bindingGO:00426059.6HLA-A, HLA-B, HLA-DRB1
6tumor necrosis factor-activated receptor activityGO:00050319.4TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Sources for Palindromic Rheumatism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet