MCID: PLN005
MIFTS: 43

Palindromic Rheumatism malady

Category: Rare diseases

Aliases & Classifications for Palindromic Rheumatism

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Aliases & Descriptions for Palindromic Rheumatism:

Name: Palindromic Rheumatism 11 47 38 13 67
Hench-Rosenberg Syndrome 11 47
Hench's Syndrome 11 47
 
Recurrent Episodes of Pain, Swelling, Warmth and Stiffness of Joints 47
Palindromic Rheumatism Syndrome 47

Classifications:



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Disease Ontology11 DOID:1166
ICD1029 M12.3, M12.30
MeSH38 C538103

Summaries for Palindromic Rheumatism

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Disease Ontology:11 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

MalaCards based summary: Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to rheumatoid arthritis and systemic lupus erythematosus, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways are LDL Oxidation in Atherogenesis and Rheumatoid arthritis. Affiliated tissues include neutrophil, lung and heart, and related mouse phenotypes are neoplasm and hematopoietic system.

Wikipedia:70 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

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Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis28.8CRP, HLA-DRB1, IL1B, PADI4, PRTN3, PTPN22
2systemic lupus erythematosus28.8CRP, HLA-DRB1, PRTN3, PTPN22, TNF, TNFRSF1B
3autosomal recessive secondary polycythemia not associated with vhl gene10.7MEFV, TNFRSF1A
4adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency10.7MEFV, TNFRSF1A
5thyroid malformation10.6IL1B, TNF
6hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.6IL1B, TNF
7progressive locomotor ataxia10.6HLA-A, HLA-DRB1
8stomatocytosis ii10.6MEFV, TNF
9common variable immunodeficiency10.6HLA-DRB1, TNF
10pure mitochondrial myopathy10.6MEFV, TNFRSF1A
11parsonage turner syndrome10.6HLA-DRB1, TNF
12weber syndrome10.6HLA-DRB1, TNF
13baetz-greenwalt syndrome10.5IL1B, TNF
14myopathy-growth delay-intellectual disability-hypospadias syndrome10.5HLA-DRB1, TNF
15pulmonary hypertension10.5IL1B, TNF
16krieble bixler syndrome10.5HLA-DRB1, TNF
17familial cold-induced inflammatory syndrome 110.5IL1B, MEFV, TNFRSF1A
18abdominal chemodectomas with cutaneous angiolipomas10.5HLA-DRB1, PTPN22, TNF
19cinca syndrome10.5IL1B, MEFV, TNFRSF1A
20uveoparotid fever10.5TNF, TNFRSF1B
21brain stem cancer10.5TNF, TNFRSF1B
22multiple sclerosis 510.5MEFV, TNF, TNFRSF1A
23spastic paraplegia-paget disease of bone syndrome10.5HLA-DRB1, IL1B, TNF
24meier-gorlin syndrome 310.5IL1B, MEFV, TNF
25retroperitoneal fibrosis10.5HLA-DRB1, IL1B, TNF
26hereditary conventional renal cell carcinoma10.5HLA-DRB1, PTPN22, TNF
27cerebral atherosclerosis10.4TNF, TNFRSF1A, TNFRSF1B
28scrotum paget's disease10.4IL1B, TNF
29stone in bladder diverticulum10.4TNF, TNFRSF1B
30arthritis10.4
31fetal erythroblastosis10.4TNF, TNFRSF1A, TNFRSF1B
32salpingitis10.4TNF, TNFRSF1A, TNFRSF1B
33siderosis10.4HLA-A, TNFRSF10A
34neuromuscular disease10.4TNF, TNFRSF1B
35adult malignant hemangiopericytoma10.4HLA-DRB1, IL1B, TNF
36conjunctival pigmentation10.4HLA-A, HLA-DRB1, PTPN22
37night blindness10.4TNF, TNFRSF1B
38babesiosis10.4IL1B, MEFV, TNF
39lethal midline granuloma10.4HLA-DRB1, IL1B, TNF
40panner disease10.4CRP, TNF
41lipodermatosclerosis10.4HLA-A, HLA-DRB1, TNF
42potato nose10.4HLA-A, HLA-DRB1, TNF
43arachnoiditis10.4HLA-A, HLA-DRB1, TNF
44uterine inversion10.4IL1B, TNF, TNFRSF1A
45sensorineural hearing loss10.4HLA-A, HLA-DRB1, TNF
46hemophagocytic lymphohistiocytosis10.4HLA-A, HLA-DRB1, TNF
47central gyrate choroidal dystrophy10.4CRP, HLA-DRB1, MEFV
48warm antibody hemolytic anemia10.4IL1B, TNF
49antigen-peptide-transporter 2 deficiency10.4HLA-A, PTPN22, TNF
50foster-kennedy syndrome10.4HLA-A, HLA-DRB1, TNFRSF10B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to palindromic rheumatism

Symptoms for Palindromic Rheumatism

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UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

Drugs & Therapeutics for Palindromic Rheumatism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Palindromic Rheumatism


Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

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Anatomical Context for Palindromic Rheumatism

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MalaCards organs/tissues related to Palindromic Rheumatism:

35
Neutrophil, Lung, Heart

Animal Models for Palindromic Rheumatism or affiliated genes

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MGI Mouse Phenotypes related to Palindromic Rheumatism:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF1A, TNFRSF1B
2MP:00053978.0IL1B, LAIR1, MEFV, PADI4, PRTN3, PTPN22
3MP:00053877.0CRP, ERBB3, IL1B, LAIR1, MEFV, PADI4

Publications for Palindromic Rheumatism

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Articles related to Palindromic Rheumatism:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. (24623460)
2014
2
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. (25028368)
2014
3
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. (24797773)
2014
4
Palindromic rheumatism: a pre-rheumatoid arthritis state? (23028026)
2012
5
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. (18412310)
2008
6
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. (18512803)
2008
7
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. (17763205)
2007
8
Palindromic rheumatism: different genetic background implies a distinct disease entity. (17038462)
2006
9
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. (17187097)
2006
10
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. (16724377)
2006
11
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. (16189657)
2005
12
Palindromic rheumatism and other relapsing arthritis. (15454124)
2004
13
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. (12415587)
2002
14
Palindromic rheumatism. (12408287)
2002
15
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. (24387063)
2002
16
A patient with severe palindromic rheumatism and frequent episodes of pain. (11300148)
2001
17
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. (10648016)
2000
18
Palindromic rheumatism: effect of dietary manipulation. (10895376)
2000
19
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. (10090159)
1999
20
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. (10063316)
1999
21
Remission in palindromic rheumatism during pregnancy. (8478889)
1993
22
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. (1450509)
1992
23
Palindromic rheumatism: a response to chloroquine. (2023196)
1991
24
Palindromic rheumatism: a case history. (2396876)
1990
25
Palindromic rheumatism: you just have to think about it! (3490340)
1986
26
Palindromic rheumatism and Felty's syndrome. (3876082)
1985
27
Palindromic rheumatism in two non-identical brothers with identical HLA including DR4. (3872102)
1985
28
Prognostic factors in palindromic rheumatism. (6610463)
1984
29
Familial palindromic rheumatism: a possible association with HLA. (6606398)
1983
30
A case of palindromic rheumatism suggestive of immune complex disease. (6214631)
1982
31
Palindromic rheumatism: a review. (7021825)
1981
32
Palindromic rheumatism. Clinical and serum complement study. (843112)
1977
33
Palindromic rheumatism: an allergic manifestation? (300382)
1977
34
Letter: Palindromic rheumatism. (4830920)
1974
35
Palindromic rheumatism: a request. (4538871)
1972
36
Palindromic rheumatism. Clinical and immunological studies. (5314707)
1971
37
Palindromic rheumatism. What is it? (4227601)
1967
38
Palindromic rheumatism treated with indomethacin. (5825311)
1965
39
Palindromic rheumatism: a clinical description and an electrophoretic analysis of the synovial fluid. (13292181)
1955
40
Palindromic rheumatism with special reference to the therapeutic results with gold and ACTH. (13178540)
1954
41
Palindromic rheumatism. (14799163)
1951
42
Palindromic rheumatism. (14890929)
1951
43
Palindromic rheumatism. (14806892)
1950
44
A Variant of Rheumatoid Arthritis resembling Palindromic Rheumatism. (18623792)
1949
45
Palindromic Rheumatism. (18623788)
1948
46
Treatment of so-called palindromic rheumatism with gold compounds. (18100848)
1948
47
PALINDROMIC RHEUMATISM. (20324282)
1947
48
A unique heart tetralogy with palindromic rheumatism. (20257875)
1947
49
Palindromic rheumatism in children. (21019385)
1946
50
Palindromic rheumatism. (20278688)
1946

Variations for Palindromic Rheumatism

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Expression for genes affiliated with Palindromic Rheumatism

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Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for genes affiliated with Palindromic Rheumatism

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Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1B, TNF
29.7HLA-DRB1, IL1B, TNF
39.7HLA-DRB1, IL1B, TNF
49.7HLA-DRB1, IL1B, TNF
59.7IL1B, TNF, TNFRSF1A
69.6TNF, TNFRSF1A, TNFRSF1B
7
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
89.6TNF, TNFRSF1A, TNFRSF1B
9
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
10
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
119.6TNF, TNFRSF1A, TNFRSF1B
12
Show member pathways
9.6TNF, TNFRSF1A, TNFRSF1B
13
Show member pathways
9.6HLA-A, HLA-DRB1, IL1B
149.4HLA-DRB1, IL1B, TNF, TNFRSF1A
15
Show member pathways
9.4HLA-DRB1, IL1B, TNF, TNFRSF1A
169.4IL1B, TNF, TNFRSF1A, TNFRSF1B
179.3HLA-A, HLA-DRB1, TNF, TNFRSF1A
189.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
19
Show member pathways
9.1HLA-A, TNF, TNFRSF10A, TNFRSF10B
20
Show member pathways
9.0IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
21
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
22
Show member pathways
9.0TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
238.8IL1B, PTPN22, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B
24
Show member pathways
8.7IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
25
Show member pathways
8.6HLA-A, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26
Show member pathways
8.5IL1B, PTPN22, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
27
Show member pathways
8.4HLA-A, HLA-DRB1, IL1B, TNF, TNFRSF10A, TNFRSF10B
28
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
29
Show member pathways
8.2ERBB3, IL1B, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
30
Show member pathways
6.4CRP, ERBB3, HLA-A, HLA-DRB1, IL1B, LAIR1

GO Terms for genes affiliated with Palindromic Rheumatism

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Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.8HLA-A, HLA-DRB1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
2plasma membraneGO:00058866.3ERBB3, HLA-A, HLA-DRB1, LAIR1, MRAP, PRTN3

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
2sequestering of triglycerideGO:003073010.6IL1B, TNF
3chronic inflammatory response to antigenic stimulusGO:000243910.6IL1B, TNF
4positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
5death-inducing signaling complex assemblyGO:007155010.5TNF, TNFRSF1A
6positive regulation of heterotypic cell-cell adhesionGO:003411610.5IL1B, TNF
7positive regulation of fever generationGO:003162210.5IL1B, TNF
8negative regulation of lipid catabolic processGO:005099510.5IL1B, TNF
9activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.4TNFRSF10A, TNFRSF10B
10positive regulation of ceramide biosynthetic processGO:200030410.4TNF, TNFRSF1A
11regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.4TNFRSF10A, TNFRSF10B
12regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
13regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF, TNFRSF1A
14positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IL1B, TNF, TNFRSF1B
15negative regulation of inflammatory responseGO:005072810.3MEFV, TNFRSF1A, TNFRSF1B
16lipopolysaccharide-mediated signaling pathwayGO:003166310.2IL1B, PTPN22, TNF
17negative regulation of lipid storageGO:001088810.2CRP, TNF
18intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.2TNF, TNFRSF1A, TNFRSF1B
19extrinsic apoptotic signaling pathwayGO:009719110.1TNF, TNFRSF10A, TNFRSF1B
20cellular response to mechanical stimulusGO:00712609.7IL1B, TNFRSF10A, TNFRSF10B, TNFRSF1A
21positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.7IL1B, TNF, TNFRSF10B, TNFRSF1A
22activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.7TNF, TNFRSF10A, TNFRSF10B
23tumor necrosis factor-mediated signaling pathwayGO:00332099.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
24extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A
25regulation of apoptotic processGO:00429819.4TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
26cell surface receptor signaling pathwayGO:00071669.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
27response to lipopolysaccharideGO:00324969.1IL1B, PTPN22, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
28positive regulation of gene expressionGO:00106288.7CRP, ERBB3, IL1B, PTPN22, TNF
29regulation of cell proliferationGO:00421278.5ERBB3, TNF, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B
30inflammatory responseGO:00069548.3CRP, IL1B, MEFV, TNF, TNFRSF10A, TNFRSF10B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TRAIL bindingGO:004556910.1TNFRSF10A, TNFRSF10B
2tumor necrosis factor-activated receptor activityGO:00050319.3TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF1B

Sources for Palindromic Rheumatism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet