MCID: PLM029
MIFTS: 33

Palmoplantar Keratosis malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Palmoplantar Keratosis

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Aliases & Descriptions for Palmoplantar Keratosis:

Name: Palmoplantar Keratosis 10 12 65
Keratoderma, Palmoplantar 45 36
Palmoplantar Keratoderma 10 45
 
Keratoderma, Palmoplantar, Diffuse 65
Keratosis Palmaris Et Plantaris 10
Keratoderma Palmoplantar 47

Classifications:



External Ids:

Disease Ontology10 DOID:3390
ICD1027 L85.2
MeSH36 D007645
NCIt42 C34748
UMLS65 C0022596

Summaries for Palmoplantar Keratosis

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NIH Rare Diseases:45 Palmoplantar keratoderma (ppk) is a group of conditions characterized by thickening of the palms and soles of the feet. ppk can also be an associated feature of different syndromes. in rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. ppk can either be inherited or acquired. acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, or medications. the hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). they can be inherited in an autosomal dominant or autosomal recessive patterns. last updated: 4/29/2011

MalaCards based summary: Palmoplantar Keratosis, also known as keratoderma, palmoplantar, is related to haim-munk syndrome and palmoplantar keratoderma, nonepidermolytic. An important gene associated with Palmoplantar Keratosis is CTSC (Cathepsin C), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Cell adhesion_Endothelial cell contacts by junctional mechanisms. Affiliated tissues include skin, t cells and brain, and related mouse phenotypes are integument and growth/size/body region.

Disease Ontology:10 A keratosis characterized by abnormal thickening of the palms and the soles.

Wikipedia:68 Meleda disease (MDM) or \"mal de Meleda\", also called Mljet disease, keratosis palmoplantaris and... more...

Related Diseases for Palmoplantar Keratosis

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Diseases related to Palmoplantar Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1haim-munk syndrome31.2CTSC, SLURP1
2palmoplantar keratoderma, nonepidermolytic31.1KRT1, KRT9
3palmoplantar keratoderma, epidermolytic30.4CTSC, DSG1, GJB2, KRT1, KRT16, KRT9
4keratosis palmaris et plantaris-clinodactyly syndrome12.8
5keratoderma, palmoplantar, with deafness12.7
6keratoderma, palmoplantar, punctate type ia12.6
7keratoderma palmoplantar spastic paralysis12.5
8palmoplantar keratoderma, nagashima type10.6
9papillon-lefevre syndrome10.4
10tyrosinemia, type ii10.4
11punctate palmoplantar keratoderma10.4
12white sponge nevus 110.3KRT1, KRT9
13acantholytic acanthoma10.3KRT1, KRT9
14ichthyosis histrix, curth-macklin type10.3KRT1, KRT9
15drug psychosis10.3KRT1, KRT9
16anal fistula10.3
17portal hypertension10.3
18pancreatic intraductal papillary-mucinous adenoma10.2DSG1, DSP
19pervasive developmental disorder10.2DSG1, DSP
20impetigo herpetiformis10.1DSG1, DSP
21bart-pumphrey syndrome10.1GJB2, LOR
22myocardial infarction10.1
23breast cancer10.1
24obesity10.1
25preterm premature rupture of the membranes10.1
26lipoprotein lipase deficiency10.1
27leukemia10.1
28ovarian clear cell carcinoma10.1
29oligohydramnios10.1
30melanoma10.1
31astrocytoma10.1
32measles10.1
33systolic heart failure10.1
34glioblastoma10.1
35mutagen sensitivity10.1
36endotheliitis10.1
37ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.1DSG1, DSP
38syndactyly, type iii10.1GJB2, LOR
39troyer syndrome10.1GJB2, SLURP1
40dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis10.0DSP, JUP
41arrhythmogenic right ventricular dysplasia 810.0DSP, JUP
42familial isolated arrhythmogenic ventricular dysplasia, left dominant form10.0DSP, JUP
43contact dermatitis10.0KRT16, LOR
44frontotemporal dementia, right temporal atrophy variant10.0DSP, JUP
45mitf-related melanoma and renal cell carcinoma predisposition syndrome10.0DSP, JUP
46hypercholesterolemia, familial10.0DSP, JUP
47arrhythmogenic right ventricular dysplasia 1210.0DSP, JUP
48braddock syndrome10.0DSG1, DSP, KRT1
49brugada syndrome10.0KRT16, KRT9, SLURP1
50erythrokeratodermia variabilis et progressiva10.0GJB2, LOR

Graphical network of the top 20 diseases related to Palmoplantar Keratosis:



Diseases related to palmoplantar keratosis

Symptoms for Palmoplantar Keratosis

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Drugs & Therapeutics for Palmoplantar Keratosis

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Drugs for Palmoplantar Keratosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2Gastrointestinal AgentsPhase 36401
3Immunologic FactorsPhase 318483
4AnalgesicsPhase 39358
5Peripheral Nervous System AgentsPhase 318510
6Immunosuppressive AgentsPhase 310422
7Analgesics, Non-NarcoticPhase 35184
8Anti-Inflammatory AgentsPhase 38478
9Anti-Inflammatory Agents, Non-SteroidalPhase 33549
10Antirheumatic AgentsPhase 38496
11EmollientsPhase 3121
12Dermatologic AgentsPhase 34555
13
Acitretinapproved3055079-83-96437841, 5284513
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
(all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
(all-e)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
13-cis-Acitretin
44707_FLUKA
44707_SIGMA
54757-46-9
55079-83-9
9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
AC-4702
AC1NR4LJ
AC1Q5T6I
Acetretin
Acitretin
Acitretin (USAN/INN)
Acitretin [USAN:INN:BAN]
Acitretina
Acitretina [Spanish]
Acitretine
Acitretine [French]
Acitretinum
Acitretinum [Latin]
BIDD:GT0617
Bio-0002
CCRIS 5534
CHEBI:50173
CHEMBL1131
CID5284513
CPD000499573
 
D02754
EINECS 259-474-4
Etretin
FT-0082892
HSDB 7187
Isoacitretin
Isoetretin
LS-96920
MLS001076667
MolPort-003-925-892
NCGC00163127-01
NCGC00163127-02
Neotigason
Retinoid etretin
Ro 10-1670
Ro 10-1670/000
Ro 13-7652
Ro-10-1670
Ro-10-1670/000
Ro-13-7652
S1368_Selleck
SAM002589973
SBB064171
SMR000499573
Soriatane
Soriatane (TN)
Soriatane, Acitretin
Spectrum5_002065
TMMP
U0279
UNII-LCH760E9T7
all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid
all-trans-Acitretin
14interferons1930
15Interferon-gamma137
16Contraceptive Agents1706
17Contraceptives, Oral3734

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar PustulosisCompletedNCT00353119Phase 3
2Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine CutaneousNot yet recruitingNCT01222000Phase 3
3The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive DiseasesCompletedNCT00005660
4Cytokines in Papillon-Lefèvre SyndromeCompletedNCT01116934

Search NIH Clinical Center for Palmoplantar Keratosis


Cochrane evidence based reviews: keratoderma, palmoplantar

Genetic Tests for Palmoplantar Keratosis

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Anatomical Context for Palmoplantar Keratosis

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MalaCards organs/tissues related to Palmoplantar Keratosis:

33
Skin, T cells, Brain, Ovary, Prostate

Animal Models for Palmoplantar Keratosis or affiliated genes

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MGI Mouse Phenotypes related to Palmoplantar Keratosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.3CTSC, DSP, GJB2, JUP, KRT1, KRT16
2MP:00053786.7CTSC, DSG1, DSP, GJB2, JUP, KRT1

Publications for Palmoplantar Keratosis

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Articles related to Palmoplantar Keratosis:

(show all 22)
idTitleAuthorsYear
1
Fc-based half-life extension of human FVIIa - a new player for hemophilia treatment? (25746366)
2015
2
Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion. (24556744)
2014
3
Alpha-1 antitrypsin deficiency, SZ phenotype: a rare type of a rare disease. Case report. (25665366)
2014
4
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside. (24384539)
2013
5
An unusual accessory mandible and a submucosal cleft palate-a case report and review of the literature. (22404912)
2013
6
Activity of crude cold-water extract of the culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.:Fr.) P.Kumm. (higher Basidiomycetes), and timolol maleate on induced ocular hypertension. (23510215)
2012
7
Establishment of an arabinose-inducible system in Stenotrophomonas maltophilia. (21503736)
2011
8
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. (19174509)
2009
9
Early and 24-hour bond strength and degree of conversion of etch-and-rinse and self-etch adhesives. (18435373)
2008
10
Transsphenoidal surgery in a patient with acromegaly and McCune-Albright syndrome: application of neuronavigation. (18173327)
2008
11
Reassessing folic acid consumption patterns in the United States (1999 2004): potential effect on neural tube defects and overexposure to folate. (18065598)
2007
12
X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation. (18047645)
2007
13
Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. (16170119)
2005
14
The role of the AP-1 transcription factors c-Fos, FosB, Fra-1 and Fra-2 in the invasion process of mammary carcinomas. (15319566)
2004
15
Phylogenomic and chemotaxonomic analysis of the endocannabinoid system. (15063097)
2004
16
Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. (11466624)
2001
17
Molecular genetics of Alzheimer's disease. (10682216)
2000
18
A case of multiple sclerosis associated with myelin associated glycoprotein neuropathy]. (10349346)
1998
19
Expression of autoantibodies to specific cytochromes P450 in a case of disulfiram hepatitis. (9833921)
1998
20
Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer. (8938136)
1996
21
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (1993656)
1991
22
Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. (1260722)
1976

Variations for Palmoplantar Keratosis

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Expression for genes affiliated with Palmoplantar Keratosis

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Search GEO for disease gene expression data for Palmoplantar Keratosis.

Pathways for genes affiliated with Palmoplantar Keratosis

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Pathways related to Palmoplantar Keratosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3DSP, JUP
29.3DSP, JUP
3
Show member pathways
9.1DSP, KRT1, KRT16

GO Terms for genes affiliated with Palmoplantar Keratosis

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Cellular components related to Palmoplantar Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00059119.1DSG1, JUP

Biological processes related to Palmoplantar Keratosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeleton organizationGO:00451049.7DSP, KRT16
2regulation of ventricular cardiac muscle cell action potentialGO:00989119.6DSP, JUP
3adherens junction organizationGO:00343329.2DSP, JUP
4epidermis developmentGO:00085449.1DSP, KRT16, KRT9
5single organismal cell-cell adhesionGO:00163378.5DSG1, DSP, JUP

Sources for Palmoplantar Keratosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet