MCID: PLM029
MIFTS: 37

Palmoplantar Keratosis malady

Rare diseases, Skin diseases categories

Summaries for Palmoplantar Keratosis

About this section
Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NIH Rare Diseases:44 Palmoplantar keratoderma (ppk) is a group of conditions characterized by thickening of the palms and soles of the feet. ppkĀ can also be an associated feature of different syndromes. in rare forms of palmoplantar keratoderma, other organs in the body may be affected in addition to the skin. ppk can either be inherited or acquired. acquired palmoplantar keratodermas may arise as a result of infections, internal disease or cancer, inflammatory skin conditions, orĀ medications. the hereditary palmoplantar keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). they can be inherited in an autosomal dominant or autosomal recessive patterns. last updated: 4/29/2011

MalaCards: Palmoplantar Keratosis, also known as palmoplantar keratoderma, is related to keratoderma and nonepidermolytic palmoplantar keratoderma. An important gene associated with Palmoplantar Keratosis is CTSC (cathepsin C). The compounds guanidine hydrochloride and glutamine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia:66 Meleda disease (MDM) or \"mal de Meleda\", also called Mljet disease, keratosis palmoplantaris and... more...

Aliases & Classifications for Palmoplantar Keratosis

About this section
Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 44NIH Rare Diseases, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

palmoplantar keratosis 9 11 63
palmoplantar keratoderma 9 44
keratoderma, palmoplantar, diffuse 63
keratosis palmaris et plantaris 9
keratoderma, palmoplantar 44
keratoderma palmoplantar 46


External Ids:

Disease Ontology9 DOID:3390
MeSH36 D007645
SNOMED-CT59 28596004, 205584004
NCIt41 C34748

Related Diseases for Palmoplantar Keratosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Palmoplantar Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1keratoderma32.1DSG1, KRT9
2nonepidermolytic palmoplantar keratoderma31.0DSG1, KRT9, CTSC
3pachyonychia congenita30.9KRT9
4skin disease30.3DSG1, GJB6, KRT9, SLURP1
5focal palmoplantar keratoderma10.8
6keratoderma palmoplantar deafness10.7
7keratosis10.7
8unna-thost palmoplantar keratoderma10.7
9diffuse palmoplantar keratoderma, bothnian type10.7
10cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome10.6
11naxos disease10.6
12olmsted syndrome10.5
13tylosis with esophageal cancer10.5
14keratosis palmoplantaris striata i, ad10.5
15autosomal dominant palmoplantar keratoderma and congenital alopecia10.5
16autosomal recessive palmoplantar keratoderma and congenital alopecia10.5
17hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome10.5
18epidermodysplasia verruciformis10.4
19alopecia10.4
20melanoma10.4
21cardiomyopathy dilated with woolly hair and keratoderma10.4
22erythrokeratodermia variabilis et progressiva10.4
23keratoderma palmoplantar spastic paralysis10.4
24leukoencephalopathy palmoplantar keratoderma10.4
25keratoderma, palmoplantar, punctate type ia10.4
26epidermolytic hyperkeratosis10.4
27dilated cardiomyopathy10.4
28meleda disease10.4
29palmoplantar keratoderma of sybert10.4
30porokeratosis plantaris palmaris et disseminata10.4
31vohwinkel syndrome10.4
32palmoplantar keratoderma, mutilating, with periorificial keratotic plaques10.4
33cole disease10.4
34palmoplantar keratoderma, bothnia type10.4
35palmoplantar keratoderma-sclerodactyly syndrome10.4
36hereditary palmoplantar keratoderma, gamborg-nielsen type10.4
37keratosis follicularis10.3
38cystic fibrosis10.3
39pityriasis rubra pilaris10.3
40myxedema10.3
41sensorineural hearing loss10.3
42ainhum10.3
43papillon-lefevre disease10.3
44dermatophytosis10.3
45hypotrichosis10.3
46myeloma10.3
47neuropathy10.3
48ovarian cancer10.3
49psoriasis10.3
50acrokeratoelastoidosis of costa10.3

Graphical network of the top 20 diseases related to Palmoplantar Keratosis:



Diseases related to palmoplantar keratosis

Symptoms for Palmoplantar Keratosis

About this section

Drugs & Therapeutics for Palmoplantar Keratosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Palmoplantar Keratosis

Drug clinical trials:

Search ClinicalTrials for Palmoplantar Keratosis

Search NIH Clinical Center for Palmoplantar Keratosis

Search CenterWatch for Palmoplantar Keratosis

Genetic Tests for Palmoplantar Keratosis

About this section

Anatomical Context for Palmoplantar Keratosis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Palmoplantar Keratosis:

34
Skin

Animal Models for Palmoplantar Keratosis or affiliated genes

About this section

Publications for Palmoplantar Keratosis

About this section
Sources:
53PubMed
See all sources

Articles related to Palmoplantar Keratosis:

(show all 13)
idTitleAuthorsYear
1
Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. (24207119)
2013
2
Possible nagashima-type palmoplantar keratosis in two siblings. (23626539)
2013
3
Atypical nail dystrophy in a possible case of Nagashima-type palmoplantar keratosis. (21950725)
2012
4
Suspected Nagashima-type palmoplantar keratosis with atypical hyperkeratotic lesions on the ears. (22640937)
2012
5
A familial case of Nagashima-type palmoplantar keratosis. (20542838)
2010
6
Dermatitis herpetiformis Duhring with palmoplantar keratosis. (14674919)
2003
7
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. (10581027)
1999
8
Hereditary palmoplantar keratosis of the Gamborg Nielsen type. Clinical and ultrastructural characteristics of a new type of autosomal recessive palmoplantar keratosis. (2260881)
1990
9
Cardiac abnormalities in familial palmoplantar keratosis. (2945574)
1986
10
Punctate palmoplantar keratosis acuminata. An unusual form of tuberculid. (7174181)
1982
11
Palmoplantar keratosis acuminata with facial sebaceous hyperplasia. (4809220)
1974
12
Palmoplantar keratosis of Darier's disease and multiple abnormalities. Ultrastructural study]. (5562223)
1971
13
Myasthenia with systemic lupus and palmoplantar keratosis. (5124413)
1971

Variations for Palmoplantar Keratosis

About this section

Expression for genes affiliated with Palmoplantar Keratosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Palmoplantar Keratosis

Search GEO for disease gene expression data for Palmoplantar Keratosis.

Pathways for genes affiliated with Palmoplantar Keratosis

About this section

Compounds for genes affiliated with Palmoplantar Keratosis

About this section
Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank
See all sources

Compounds related to Palmoplantar Keratosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride469.5TAT, CTSC
2glutamine469.3TAT, CTSC, KRT9
3morphine46 52 30 1212.1TAT, RHBDF2
4serine468.3SERPINB7, DSG1, TAT, CTSC

GO Terms for genes affiliated with Palmoplantar Keratosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Palmoplantar Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:0059119.5PKP2, DSG1
2desmosomeGO:0300579.4PKP2, DSG1
3intermediate filamentGO:0058829.3KRT9, PKP2

Biological processes related to Palmoplantar Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adhesionGO:0163379.5PKP2, DSG1

Products for genes affiliated with Palmoplantar Keratosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Palmoplantar Keratosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet