MCID: PNC032
MIFTS: 36

Pancoast Tumor

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pancoast Tumor

MalaCards integrated aliases for Pancoast Tumor:

Name: Pancoast Tumor 12 14 69
Pancoast Syndrome 41 69
Superior Pulmonary Sulcus Syndrome [ambiguous] 12
Malignant Superior Sulcus Tumor 12
Pulmonary Sulcus Neoplasm 69
Pulmonary Sulcus Tumor 12
Pancoast's Syndrome 12
Pancoast's Tumour 12

Classifications:



Summaries for Pancoast Tumor

MalaCards based summary : Pancoast Tumor, also known as pancoast syndrome, is related to liver lymphoma and extragonadal nonseminomatous germ cell tumor. An important gene associated with Pancoast Tumor is EEF2 (Eukaryotic Translation Elongation Factor 2), and among its related pathways/superpathways is Vasopressin-regulated water reabsorption. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and b cells, and related phenotype is mortality/aging.

Wikipedia : 72 A Pancoast tumor is a tumor of the pulmonary apex. It is a type of lung cancer defined primarily by its... more...

Related Diseases for Pancoast Tumor

Diseases related to Pancoast Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 liver lymphoma 10.3 AFP SMUG1
2 extragonadal nonseminomatous germ cell tumor 10.3 AFP SMUG1
3 corpus luteum cyst 10.3 AFP SMUG1
4 sternum cancer 10.3 AFP SMUG1
5 extragonadal germ cell cancer 10.3 AFP SMUG1
6 scrotal carcinoma 10.3 AFP SMUG1
7 tuberculous epididymitis 10.3 AFP AVP
8 mediastinal cancer 10.3 AFP SMUG1
9 central nervous system germ cell tumor 10.3 AFP AVP
10 mature teratoma 10.3 AFP SMUG1
11 episodic pain syndrome, familial, 1 10.3
12 malignant sertoli cell tumor 10.3 AFP ENO2
13 secondary hypertrophic osteoarthropathy 10.2 AVP SMUG1
14 melanotic medulloblastoma 10.2 AFP ENO2
15 malignant teratoma 10.2 AFP ENO2
16 rete testis adenocarcinoma 10.2 AFP ENO2
17 gallbladder small cell carcinoma 10.2 ENO2 SMUG1
18 analbuminemia 10.2 AVP SLC17A5
19 plexopathy 10.2 AVP SMUG1
20 rete testis neoplasm 10.2 AFP ENO2
21 supraglottis cancer 10.2 ENO2 SMUG1
22 bronchus cancer 10.2 AVP ENO2
23 olfactory nerve neoplasm 10.2 AVP ENO2
24 pericardial tuberculosis 10.2 NELFCD SMUG1
25 brain germinoma 10.2 AFP AVP
26 rectum squamous cell carcinoma 10.2 SMUG1 TNFRSF1B
27 dysgerminoma of ovary 10.1 AFP ENO2
28 eumycotic mycetoma 10.1 NELFCD SMUG1
29 pericardium cancer 10.1 ENO2 SMUG1
30 chondromalacia 10.1 SMUG1 TNFRSF1B
31 cranial nerve malignant neoplasm 10.1 AVP ENO2
32 granulomatous myositis 10.1 SMUG1 TNFRSF1B
33 bladder neck obstruction 10.1 AFP TNFRSF1B
34 cervix small cell carcinoma 10.1 AVP ENO2
35 botryoid rhabdomyosarcoma 10.1 AFP ENO2
36 pericardial mesothelioma 10.1 ENO2 SMUG1
37 lung cancer 10.0
38 cervicitis 10.0
39 oculomotor nerve paralysis 10.0 AFP AVP SMUG1
40 third cranial nerve disease 10.0 AFP AVP SMUG1
41 sex cord-gonadal stromal tumor 10.0 AFP ENO2
42 granulomatous hepatitis 10.0 AVP TNFRSF1B
43 hypersensitivity reaction type iv disease 10.0 SMUG1 TNFRSF1B
44 teratoma 10.0 AFP ENO2
45 endometrial small cell carcinoma 10.0 AFP ENO2 SMUG1
46 cogan syndrome 10.0 SMUG1 TNFRSF1B
47 cell type cancer 9.9 AFP ENO2 SMUG1
48 small cell cancer of the lung 9.9
49 reflex sympathetic dystrophy 9.9
50 mycobacterium tuberculosis 1 9.9

Graphical network of the top 20 diseases related to Pancoast Tumor:



Diseases related to Pancoast Tumor

Symptoms & Phenotypes for Pancoast Tumor

MGI Mouse Phenotypes related to Pancoast Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 AFP AVP CREB3L2 EEF2 SLC17A5 SMUG1

Drugs & Therapeutics for Pancoast Tumor

Drugs for Pancoast Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
3
Vindesine Approved, Investigational Phase 2 53643-48-4, 59917-39-4 40839
4
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
5
Cobalt Phase 2 7440-48-4 104729
6 Alkylating Agents Phase 2
7 Mitomycins Phase 2
8 Topoisomerase Inhibitors Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 2
10 Anti-Bacterial Agents Phase 2
11 Etoposide phosphate Phase 2
12 Antimitotic Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors Completed NCT00062439 Phase 2 cisplatin;docetaxel;etoposide
2 Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806) Completed NCT00128037 Phase 2 mitomycin C, vindesine, cisplatin and radiotherapy
3 Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors Completed NCT00984997 Phase 2 Cisplatin;Etoposide
4 SWOG-9416: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage III Non-small Cell Lung Cancer Completed NCT00002642 Phase 2 cisplatin;etoposide

Search NIH Clinical Center for Pancoast Tumor

Cochrane evidence based reviews: pancoast syndrome

Genetic Tests for Pancoast Tumor

Anatomical Context for Pancoast Tumor

MalaCards organs/tissues related to Pancoast Tumor:

38
Lung, Bone, B Cells

Publications for Pancoast Tumor

Articles related to Pancoast Tumor:

(show top 50) (show all 69)
# Title Authors Year
1
Pancoast tumor approach through oesophagus. ( 28913160 )
2017
2
Less Invasive Approach to Pancoast Tumor in a Partitioned Incision. ( 28484150 )
2017
3
A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report. ( 28264709 )
2017
4
Video-assisted pulmonary lobectomy combined with transmanubrial approach for anterior Pancoast tumor resection: case report. ( 27079507 )
2016
5
An unusual cause of acute headache: subarachnoid free air secondary to spontaneous bronchopleurodurosubarachnoid fistula from a Pancoast tumor. ( 27594957 )
2016
6
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 27257289 )
2016
7
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 28025378 )
2016
8
Pancoast Tumor of the Lung. ( 27150220 )
2016
9
VATS lobectomy combined with limited Shaw-Paulson thoracotomy for posterolateral Pancoast tumor. ( 26429643 )
2015
10
Expert's comment concerning "Chest wall reconstruction after en bloc Pancoast tumor resection with the use of MatrixRib and SILC Fixation systems: technical note" (Marcin Czyz, Emmanuel Addae-Boateng, Bronek M. Boszczyk) : Update in Pancoast Tobias en bloc resections. ( 26315146 )
2015
11
Painful Metastasis in the Lunate Bone as the First Symptom of a Pancoast Tumor; a Case Report and Review of the Literature. ( 26578844 )
2015
12
Case Report: En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. ( 26306134 )
2015
13
A Case of Pancoast Tumor with Unusual Presentation. ( 27917240 )
2015
14
Combined treatment modalities in Pancoast tumor: results of a monocentric retrospective study. ( 26730751 )
2015
15
The "cut-in patch-out" technique for Pancoast tumor resections results in postoperative pain reduction: a case control study. ( 25265907 )
2014
16
Pancoast tumor: a modern perspective on an old problem. ( 23702478 )
2013
17
Prolongation of life by adoptive cell therapy with cascade primed immune cells in four patients with non-small cell lung cancer stages IIIB and IV and a pancoast tumor: a case series. ( 24330627 )
2013
18
Pancoast tumor: the role of magnetic resonance imaging. ( 23607032 )
2013
19
Delayed paraplegia due to "surgiceloma" following thoracotomy for a Pancoast tumor. ( 23591929 )
2013
20
Squamous cell carcinoma on the remaining sequel of tuberculosis, presented as pancoast tumor 8 years later. ( 25191429 )
2012
21
Hepatoid pancoast tumor. A case report and review of the literature. ( 22677427 )
2012
22
Images in emergency medicine. Adult female with malignant pain. Horner's syndrome as a result of a Pancoast tumor. ( 21353907 )
2011
23
Pulmonary echinococcosis mimicking Pancoast tumor. ( 19660333 )
2010
24
Bone single photon emission computed tomography (SPECT) in a patient with Pancoast tumor: a case report. ( 21120438 )
2010
25
Diffuse large B-cell lymphoma presenting as pancoast tumor. ( 20385989 )
2010
26
Paravertebral cervical nerve block in a patient suffering from a Pancoast tumor. ( 21134120 )
2010
27
Tension pneumocephalus complicating Pancoast tumor resection. ( 19254944 )
2009
28
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
29
Anterior approach for Pancoast tumor resection. ( 24415052 )
2007
30
Hydatid disease of the ribs mimicking pancoast tumor: report of two cases. ( 18027344 )
2007
31
Pancoast tumor resection with preservation of brachial plexus and hand function. ( 17613206 )
2007
32
Pulmonary leiomyosarcoma presenting as a pancoast tumor. ( 17673374 )
2007
33
Multimodality therapy for Pancoast tumor. ( 16955087 )
2006
34
Delay by patients and doctors in treatment of Pancoast tumor. ( 16865645 )
2006
35
Management of a superior sulcus (pancoast) tumor. ( 16370449 )
2005
36
Reflex sympathetic dystrophy and pancoast tumor. ( 15365437 )
2004
37
Cervicobrachialgia and pancoast tumor: value of standard anteroposterior cervical radiographs in early diagnosis. ( 15553951 )
2004
38
Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation. ( 15609647 )
2004
39
Tuberculosis presenting as Pancoast tumor. ( 14602329 )
2003
40
Clinical images: Wegener's granulomatosis presenting as Pancoast tumor. ( 10693892 )
2000
41
Pain-relieving posterior rod fixation with segmental sublaminar wiring for Pancoast tumor invading the vertebrae. ( 10721947 )
1999
42
Superior sulcus (Pancoast) tumor: experience with 105 patients. ( 9692463 )
1998
43
Complete excision of the lower trunk and C8 and T1 nerve roots in a patient with Pancoast tumor with a resulting fully functional hand. ( 9238751 )
1997
44
Subarachnoid-pleural fistula after resection of a pancoast tumor with hyponatremia. ( 7677501 )
1995
45
Combined radiosurgical treatment of Pancoast tumor. ( 8279890 )
1994
46
Surgical treatment of Pancoast tumor. ( 8320251 )
1993
47
Pancoast tumor as a cause of reflex sympathetic dystrophy. ( 8229248 )
1993
48
Primary hemangiopericytoma presenting as a Pancoast tumor. ( 8431033 )
1993
49
Pancoast tumor: use of MRI for tumor staging. ( 1470977 )
1992
50
Pancoast tumor: radiation therapy alone versus preoperative radiation therapy and surgery. ( 1869459 )
1991

Variations for Pancoast Tumor

Expression for Pancoast Tumor

Search GEO for disease gene expression data for Pancoast Tumor.

Pathways for Pancoast Tumor

Pathways related to Pancoast Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 AVP CREB3L2

GO Terms for Pancoast Tumor

Biological processes related to Pancoast Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 8.62 AVP TNFRSF1B

Sources for Pancoast Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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