MCID: PNC032
MIFTS: 33

Pancoast Tumor malady

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pancoast Tumor

Aliases & Descriptions for Pancoast Tumor:

Name: Pancoast Tumor 12 14 69
Pancoast Syndrome 42 69
Superior Pulmonary Sulcus Syndrome [ambiguous] 12
Malignant Superior Sulcus Tumor 12
Pulmonary Sulcus Neoplasm 69
Pulmonary Sulcus Tumor 12
Pancoast's Syndrome 12
Pancoast's Tumour 12

Classifications:



Summaries for Pancoast Tumor

MalaCards based summary : Pancoast Tumor, also known as pancoast syndrome, is related to bladder carcinoma in situ and visual cortex disease. An important gene associated with Pancoast Tumor is EEF2 (Eukaryotic Translation Elongation Factor 2), and among its related pathways/superpathways is Vasopressin-regulated water reabsorption. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and b cells, and related phenotype is mortality/aging.

Wikipedia : 71 A Pancoast tumor, also called a pulmonary sulcus tumor or superior sulcus tumor, is a tumor of the... more...

Related Diseases for Pancoast Tumor

Diseases related to Pancoast Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 bladder carcinoma in situ 10.2 AFP SMUG1
2 visual cortex disease 10.2 AFP SMUG1
3 dementia 10.2 AFP SMUG1
4 nutritional deficiency disease 10.2 AFP SMUG1
5 novak syndrome 10.2 AFP SMUG1
6 atrophic rhinitis 10.2 AFP SMUG1
7 ovarian germ cell teratoma 10.2 AFP SMUG1
8 bagassosis 10.2 AFP AVP
9 inhibited male orgasm 10.2 AFP SMUG1
10 uterine disease 10.2 AFP SMUG1
11 childhood kidney cell carcinoma 10.2 AFP AVP
12 infiltrating renal pelvis transitional cell carcinoma 10.2 AFP ENO2
13 omphalocele 10.2 AVP SMUG1
14 thrombophlebitis 10.2 AFP ENO2
15 gonococcal seminal vesiculitis 10.2 AVP SMUG1
16 laryngeal small cell carcinoma 10.2 ENO2 SMUG1
17 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.2 AVP SLC17A5
18 central nervous system sarcoma 10.1 AFP AVP
19 sphenoid sinus squamous cell carcinoma 10.1 AFP ENO2
20 cranial nerve disease 10.1 AFP ENO2
21 sarcomatoid squamous cell skin carcinoma 10.1 SMUG1 TNFRSF1B
22 anal colloid adenocarcinoma 10.1 AVP SMUG1
23 croup 10.1 SMUG1 TNFRSF1B
24 uterine corpus epithelioid leiomyoma 10.1 AFP TNFRSF1B
25 mammary paget's disease 10.1 SMUG1 TNFRSF1B
26 pneumonia 10.1 AFP ENO2
27 hyperandrogenism 10.1 ENO2 SMUG1
28 cerebral arterial disease 10.1 CREB3L2 ENO2
29 pinta disease 10.1 CREB3L2 ENO2
30 spindle cell rhabdomyosarcoma 10.1 AFP ENO2
31 acute serous otitis media 10.1 AFP AVP SMUG1
32 sternum lymphoma 10.0 AVP ENO2
33 ampulla of vater adenosquamous carcinoma 10.0 AFP AVP SMUG1
34 ovarian papillary neoplasm 10.0 ENO2 SMUG1
35 rectum leiomyoma 10.0 AFP ENO2 SMUG1
36 malignant pleural solitary fibrous tumor 10.0 AFP ENO2 SMUG1
37 elephantiasis 10.0 NELFCD SMUG1
38 pharynx cancer 10.0 AVP ENO2 SMUG1
39 periventricular leukomalacia 10.0 NELFCD SMUG1
40 hypertrophic elongation of cervix 10.0 AVP TNFRSF1B
41 small intestinal sarcoma 10.0 CREB3L2 ENO2 SMUG1
42 gestational choriocarcinoma 10.0 CREB3L2 ENO2 SMUG1
43 newcastle disease 10.0 SMUG1 TNFRSF1B
44 mediastinum sarcoma 10.0 CREB3L2 ENO2
45 lung cancer 9.9
46 cervicitis 9.9
47 colorectal cancer 1 9.9 CREB3L2 ENO2
48 lymph node adenoid cystic carcinoma 9.8 SMUG1 TNFRSF1B
49 reflex sympathetic dystrophy 9.8
50 tuberculosis 9.8

Graphical network of the top 20 diseases related to Pancoast Tumor:



Diseases related to Pancoast Tumor

Symptoms & Phenotypes for Pancoast Tumor

MGI Mouse Phenotypes related to Pancoast Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 AFP AVP CREB3L2 EEF2 SLC17A5 SMUG1

Drugs & Therapeutics for Pancoast Tumor

Drugs for Pancoast Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Vindesine Approved Phase 2 59917-39-4, 53643-48-4 40839
4
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
5
Cobalt Phase 2 7440-48-4 104729
6 Alkylating Agents Phase 2
7 Mitomycins Phase 2
8 Topoisomerase Inhibitors Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 2
10 Anti-Bacterial Agents Phase 2
11 Etoposide phosphate Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Antimitotic Agents Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2
15
Fluorouracil Approved Phase 1 51-21-8 3385
16
Belinostat Approved, Investigational Phase 1 866323-14-0
17 Histone Deacetylase Inhibitors Phase 1
18 Androgens Phase 1
19 Immunosuppressive Agents Phase 1
20 Antimetabolites Phase 1
21 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors Completed NCT00984997 Phase 2
2 Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806) Completed NCT00128037 Phase 2
3 S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors Completed NCT00062439 Phase 2
4 SWOG-9416: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage III Non-small Cell Lung Cancer Completed NCT00002642 Phase 2
5 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1

Search NIH Clinical Center for Pancoast Tumor

Cochrane evidence based reviews: pancoast syndrome

Genetic Tests for Pancoast Tumor

Anatomical Context for Pancoast Tumor

MalaCards organs/tissues related to Pancoast Tumor:

39
Lung, Bone, B Cells

Publications for Pancoast Tumor

Articles related to Pancoast Tumor:

(show top 50) (show all 66)
id Title Authors Year
1
An unusual cause of acute headache: subarachnoid free air secondary to spontaneous bronchopleurodurosubarachnoid fistula from a Pancoast tumor. ( 27594957 )
2016
2
Pancoast Tumor of the Lung. ( 27150220 )
2016
3
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 27257289 )
2016
4
Video-assisted pulmonary lobectomy combined with transmanubrial approach for anterior Pancoast tumor resection: case report. ( 27079507 )
2016
5
Ultrasonographic Imaging of a Pancoast Tumor Presenting with Breakthrough Pain and Not Visualized by Plane Radiograph. ( 28025378 )
2016
6
Painful Metastasis in the Lunate Bone as the First Symptom of a Pancoast Tumor; a Case Report and Review of the Literature. ( 26578844 )
2015
7
VATS lobectomy combined with limited Shaw-Paulson thoracotomy for posterolateral Pancoast tumor. ( 26429643 )
2015
8
A Case of Pancoast Tumor with Unusual Presentation. ( 27917240 )
2015
9
Combined treatment modalities in Pancoast tumor: results of a monocentric retrospective study. ( 26730751 )
2015
10
Case Report: En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. ( 26306134 )
2015
11
Expert's comment concerning "Chest wall reconstruction after en bloc Pancoast tumor resection with the use of MatrixRib and SILC Fixation systems: technical note" (Marcin Czyz, Emmanuel Addae-Boateng, Bronek M. Boszczyk) : Update in Pancoast Tobias en bloc resections. ( 26315146 )
2015
12
The "cut-in patch-out" technique for Pancoast tumor resections results in postoperative pain reduction: a case control study. ( 25265907 )
2014
13
Pancoast tumor: a modern perspective on an old problem. ( 23702478 )
2013
14
Prolongation of life by adoptive cell therapy with cascade primed immune cells in four patients with non-small cell lung cancer stages IIIB and IV and a pancoast tumor: a case series. ( 24330627 )
2013
15
Pancoast tumor: the role of magnetic resonance imaging. ( 23607032 )
2013
16
Delayed paraplegia due to "surgiceloma" following thoracotomy for a Pancoast tumor. ( 23591929 )
2013
17
Squamous cell carcinoma on the remaining sequel of tuberculosis, presented as pancoast tumor 8 years later. ( 25191429 )
2012
18
Hepatoid pancoast tumor. A case report and review of the literature. ( 22677427 )
2012
19
Images in emergency medicine. Adult female with malignant pain. Horner's syndrome as a result of a Pancoast tumor. ( 21353907 )
2011
20
Diffuse large B-cell lymphoma presenting as pancoast tumor. ( 20385989 )
2010
21
Bone single photon emission computed tomography (SPECT) in a patient with Pancoast tumor: a case report. ( 21120438 )
2010
22
Paravertebral cervical nerve block in a patient suffering from a Pancoast tumor. ( 21134120 )
2010
23
Pulmonary echinococcosis mimicking Pancoast tumor. ( 19660333 )
2010
24
Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. ( 19096322 )
2009
25
Tension pneumocephalus complicating Pancoast tumor resection. ( 19254944 )
2009
26
Anterior approach for Pancoast tumor resection. ( 24415052 )
2007
27
Pulmonary leiomyosarcoma presenting as a pancoast tumor. ( 17673374 )
2007
28
Pancoast tumor resection with preservation of brachial plexus and hand function. ( 17613206 )
2007
29
Hydatid disease of the ribs mimicking pancoast tumor: report of two cases. ( 18027344 )
2007
30
Multimodality therapy for Pancoast tumor. ( 16955087 )
2006
31
Delay by patients and doctors in treatment of Pancoast tumor. ( 16865645 )
2006
32
Management of a superior sulcus (pancoast) tumor. ( 16370449 )
2005
33
Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation. ( 15609647 )
2004
34
Cervicobrachialgia and pancoast tumor: value of standard anteroposterior cervical radiographs in early diagnosis. ( 15553951 )
2004
35
Reflex sympathetic dystrophy and pancoast tumor. ( 15365437 )
2004
36
Tuberculosis presenting as Pancoast tumor. ( 14602329 )
2003
37
Clinical images: Wegener's granulomatosis presenting as Pancoast tumor. ( 10693892 )
2000
38
Pain-relieving posterior rod fixation with segmental sublaminar wiring for Pancoast tumor invading the vertebrae. ( 10721947 )
1999
39
Superior sulcus (Pancoast) tumor: experience with 105 patients. ( 9692463 )
1998
40
Complete excision of the lower trunk and C8 and T1 nerve roots in a patient with Pancoast tumor with a resulting fully functional hand. ( 9238751 )
1997
41
Subarachnoid-pleural fistula after resection of a pancoast tumor with hyponatremia. ( 7677501 )
1995
42
Combined radiosurgical treatment of Pancoast tumor. ( 8279890 )
1994
43
Pancoast tumor as a cause of reflex sympathetic dystrophy. ( 8229248 )
1993
44
Primary hemangiopericytoma presenting as a Pancoast tumor. ( 8431033 )
1993
45
Surgical treatment of Pancoast tumor. ( 8320251 )
1993
46
Pancoast tumor: use of MRI for tumor staging. ( 1470977 )
1992
47
Small cell lung cancer presenting as a Pancoast tumor. ( 1648650 )
1991
48
Pancoast tumor: radiation therapy alone versus preoperative radiation therapy and surgery. ( 1869459 )
1991
49
Pancoast tumor presenting as cervical radiculopathy. ( 2369300 )
1990
50
Combined neurogenic and nociceptive pain in a patient with Pancoast tumor managed by epidural hydromorphone and oral carbamazepine. ( 2465531 )
1989

Variations for Pancoast Tumor

Expression for Pancoast Tumor

Search GEO for disease gene expression data for Pancoast Tumor.

Pathways for Pancoast Tumor

Pathways related to Pancoast Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.27 AVP CREB3L2

GO Terms for Pancoast Tumor

Sources for Pancoast Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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