MCID: PNC033
MIFTS: 47

Pancreas Adenocarcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Pancreas Adenocarcinoma

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33MalaCards
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MalaCards: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to adenocarcinoma and pancreatic cancer. An important gene associated with Pancreas Adenocarcinoma is KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The compounds bpde and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, t cells and endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Pancreas Adenocarcinoma

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreas adenocarcinoma 8
pancreatic adenocarcinoma 8 62


External Ids:

Disease Ontology8 DOID:4074
NCIt40 C8294

Related Diseases for Pancreas Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.5BMP6, SLC29A1, CDKN2A, ERCC1, NCAM1, RRM2
2pancreatic cancer30.4BRCA2, NCAM1, SMAD4, SLC29A1, CDKN2A
3cholangiocarcinoma30.4NCAM1, TP53, SMAD4
4esophageal cancer29.9SMAD4, TP53, CDKN2A, CHEK2
5adenoma29.9ERCC1, BRCA1, SMAD4, CDKN2A, TP53
6hepatocellular carcinoma29.7BRCA2, BMP6, SMAD4, FOXP3, CDKN2A, ERCC1
7melanoma29.7CHEK2, FOXP3, IL7, BMP6, TP53, BRCA2
8pancreatitis11.3
9peutz-jeghers syndrome10.3
10autoimmune pancreatitis10.3
11cystic fibrosis10.1
12esophagitis10.1
13hepatitis10.1
14prostatitis10.1
15leukostasis10.1SELE
16breast-ovarian cancer, familial, 210.1BRCA2
17actinic keratosis10.1TP53
18cystadenoma10.1BRCA1
19bile duct carcinoma10.1BRCA2, NCAM1
20ovarian cystadenoma10.1BRCA1, SELE
21brca1 and brca2 hereditary breast and ovarian cancer10.1BRCA2, BRCA1
22embryonal rhabdomyosarcoma10.1SMAD4, NCAM1
23peritoneal carcinoma10.1BRCA1, BRCA2
24fallopian tube cancer10.0BRCA1, BRCA2
25lynch syndrome10.0BRCA2, BRCA1
26male breast cancer10.0BRCA1, BRCA2
27atypical mole syndrome10.0CDKN2A, BRCA2
28dysgerminoma10.0BRCA2, BRCA1
29oropharyngeal cancer, adult10.0TP53, CDKN2A
30chronic lymphocytic leukemia10.0ERCC1, BRCA2, IL7
31nijmegen breakage syndrome10.0BRCA1, CHEK2
32telangiectasis10.0SMAD4, BMP6
33cowden disease10.0BRCA2, BRCA1, SMAD4
34nasopharynx carcinoma10.0TP53, CDKN2A
35bilateral breast cancer10.0CHEK2, BRCA2, BRCA1
36cystic teratoma10.0
37peritonitis10.0
38endotheliitis10.0
39xeroderma pigmentosum10.0ERCC1, BRCA1, TP53
40gynecomastia10.0BRCA1, BRCA2
41breast cancer, invasive ductal10.0TP53, BRCA1
42b-cell chronic lymphocytic leukemia10.0IL7, TP53, BRCA2
43rhabdomyosarcoma10.0NCAM1, SMAD4, TP53
44hodgkin's lymphoma10.0IL7, BRCA2, BRCA1
45bloom syndrome10.0BRCA2, BRCA1
46familial adenomatous polyposis10.0BRCA1, TP53, SMAD4
47ductal carcinoma in situ10.0BRCA1, BRCA2, TP53
48familial colorectal cancer10.0BRCA1, CDKN2A, BRCA2
49malignant peripheral nerve sheath tumor10.0NCAM1, CDKN2A
50intrahepatic cholestasis10.0

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Symptoms for Pancreas Adenocarcinoma

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Drugs & Therapeutics for Pancreas Adenocarcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

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Anatomical Context for Pancreas Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Pancreas Adenocarcinoma:

33
Pancreas, T cells, Endothelial

Animal Models for Pancreas Adenocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8TP53, SLC29A1, IL7, FOXP3, CDKN2A
2MP:00053708.7ERCC1, CDKN2A, FOXP3, SELE, TP53, SMAD4
3MP:00053678.5ERCC1, FOXP3, BRCA1, TP53, SMAD4
4MP:00053698.5SMAD4, TP53, KCNA3, BRCA1, CDKN2A, ERCC1
5MP:00028738.3SELE, TP53, SMAD4, KCNA3, BRCA2, BRCA1
6MP:00053818.3SMAD4, CDKN2A, FOXP3, BRCA2, TP53, BRCA1
7MP:00020068.2BRCA2, BRCA1, SMAD4, ERCC1, CHEK2, TP53
8MP:00053798.2CDKN2A, ERCC1, FOXP3, BRCA1, BRCA2, TP53
9MP:00053808.1SMAD4, CDKN2A, ERCC1, TP53, BRCA2, BRCA1
10MP:00107718.0SMAD4, TP53, SELE, FOXP3, ERCC1, CDKN2A
11MP:00053908.0TP53, CDKN2A, BRCA1, BMP6, ERCC1, BRCA2
12MP:00053897.7CDKN2A, BMP6, BRCA1, SMAD4, TP53, BRCA2
13MP:00053977.5CDKN2A, ERCC1, FOXP3, CHEK2, IL7, BRCA1
14MP:00053877.4SELE, SMAD4, TP53, BRCA1, BRCA2, CHEK2
15MP:00053767.4KCNA3, TP53, CDKN2A, ERCC1, FOXP3, BRCA1
16MP:00053847.3ERCC1, BRCA1, SELE, SMAD4, TP53, FOXP3
17MP:00107687.3NCAM1, BRCA1, FOXP3, CHEK2, SMAD4, TP53
18MP:00036317.1KCNA4, TP53, BRCA2, BRCA1, NCAM1, CDKN2A
19MP:00053786.7BRCA1, FOXP3, NCAM1, SELE, TP53, SMAD4
20MP:00053866.6SMAD4, SELE, CDKN2A, TP53, BRCA2, BRCA1

Publications for Pancreas Adenocarcinoma

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52PubMed
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Articles related to Pancreas Adenocarcinoma:

(show all 19)
idTitleAuthorsYear
1
Adjuvant therapy for pancreas adenocarcinoma. (22886586)
2013
2
FOLFIRINOX in locally advanced pancreas adenocarcinoma: back to the future? (23704222)
2013
3
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (22569992)
2013
4
Reply to an analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606044)
2013
5
Evolving panorama of treatment for metastatic pancreas adenocarcinoma. (23547071)
2013
6
Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression. (23360922)
2013
7
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606137)
2013
8
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. (21382702)
2012
9
Adjuvant therapy for pancreas adenocarcinoma: where are we going? (21342036)
2011
10
Differential expression of ERCC1 in pancreas adenocarcinoma: high tumor expression is associated with earlier recurrence and shortened survival after resection. (21360249)
2011
11
Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. (19851808)
2010
12
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. (19421880)
2009
13
Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]. (19548527)
2009
14
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. (19465885)
2009
15
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. (16799337)
2006
16
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. (15501974)
2004
17
Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. (11173546)
2001
18
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. (8797870)
1996
19
Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. (7804431)
1994

Variations for Pancreas Adenocarcinoma

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Expression for genes affiliated with Pancreas Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreas Adenocarcinoma

Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

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Sources:
50PathCards, 30KEGG, 55Reactome, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 12EMD Millipore, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA1, BRCA2
2
Show member pathways
9.7BRCA2, BRCA1
3
Show member pathways
9.7CHEK2, TP53
49.7CHEK2, TP53
59.6SLC29A1, RRM2
69.5BRCA1, TP53
79.5BRCA1, TP53
8
Show member pathways
9.5TP53, CDKN2A
99.5TP53, CDKN2A
109.5ERCC1, BRCA1, BRCA2
11
Show member pathways
9.5BRCA2, BRCA1, ERCC1
129.3SMAD4, TP53, BRCA1
13
Show member pathways
9.2TP53, BRCA1, CHEK2
14
Show member pathways
ATM Signaling Pathway38
9.2TP53, BRCA1, CHEK2
159.2CHEK2, BRCA1, TP53
169.2CHEK2, BRCA1, TP53
17
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2CHEK2, BRCA1, TP53
18
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.2CDKN2A, TP53, SMAD4
199.2CDKN2A, TP53, SMAD4
20
Show member pathways
9.1KCNA3, KCNJ3, KCNA4
21
Show member pathways
9.1SLC29A1, RRM2, TP53
22
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.0CDKN2A, CHEK2, BRCA1, SMAD4
238.9SMAD4, TP53, CHEK2, CDKN2A
24
Show member pathways
Cell cycle38
8.9CDKN2A, CHEK2, TP53, SMAD4
25
Show member pathways
8.9CDKN2A, RRM2, TP53
268.9CHEK2, BRCA1, BRCA2, TP53
27
Show member pathways
8.9CHEK2, BRCA1, BRCA2, TP53
288.8SMAD4, TP53, BRCA2, CDKN2A
29
Show member pathways
8.8SMAD4, TP53, BRCA2, CDKN2A
30
Show member pathways
Signaling Pathways in Glioblastoma38
8.7TP53, BRCA2, BRCA1, CDKN2A
31
Show member pathways
8.6TP53, BRCA2, BRCA1, CHEK2, ERCC1
328.6SMAD4, TP53, BRCA2, BRCA1, CHEK2
338.6SMAD4, TP53, BRCA2, BRCA1, CHEK2
34
Show member pathways
8.2CDKN2A, BMP6, BRCA1, BRCA2, TP53
35
Show member pathways
8.2CDKN2A, ERCC1, CHEK2, BRCA1, BRCA2, TP53
36
Show member pathways
DNA damage response38
8.2TP53, RRM2, BRCA1, CHEK2, CDKN2A
37
Show member pathways
8.2TP53, RRM2, BRCA1, CHEK2, CDKN2A
38
Show member pathways
8.0TP53, BRCA1, CHEK2, IL7, BMP6, CDKN2A

Compounds for genes affiliated with Pancreas Adenocarcinoma

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1bpde459.6TP53, CHEK2, BRCA1
2temozolomide45 1110.4CDKN2A, CHEK2, TP53
3bcnu459.4TP53, ERCC1, CDKN2A
45-methylcytosine45 2410.4CDKN2A, TP53, BRCA1
5lactacystin459.3SELE, ERCC1, TP53, BRCA1
6okt3459.3BMP6, IL7, SELE
7mitomycin c459.3ERCC1, BRCA1, TP53, BRCA2
8aphidicolin459.2TP53, BRCA1, CHEK2
9o6-methylguanine459.2CDKN2A, BRCA2, TP53
10rapamycin459.2IL7, ERCC1, CHEK2, FOXP3, BMP6
11hmba459.2TP53, CDKN2A, BMP6
12cyclophosphamide45 51 1111.2ERCC1, IL7, SELE, TP53, BRCA1
13gold459.1NCAM1, CDKN2A, BRCA2, BRCA1
14bleomycin45 1110.0BRCA1, BMP6, BRCA2, TP53
15cytarabine45 51 1110.9SLC29A1, CDKN2A, RRM2, TP53
16caffeine45 29 3 51 24 1113.9BMP6, CHEK2, BRCA1, TP53
17crcs458.9CDKN2A, SMAD4, TP53
18agar458.9IL7, BMP6, BRCA1, SMAD4, CDKN2A
19mg 13245 619.9SMAD4, CDKN2A, BRCA1, TP53
20docetaxel45 51 61 1111.9ERCC1, BRCA2, TP53, CDKN2A, BRCA1
21adriamycin458.8BRCA2, BRCA1, TP53, CDKN2A, CHEK2
22camptothecin45 61 1110.8CDKN2A, CHEK2, BRCA1, BRCA2, TP53
235fluorouracil458.8SLC29A1, BRCA1, ERCC1, SELE, TP53, CDKN2A
24etoposide45 51 61 1111.8SELE, BRCA1, ERCC1, CHEK2, BRCA2, TP53
25genistein45 29 61 3 24 1113.8BRCA1, BRCA2, CDKN2A, CHEK2, IL7, SELE
26tamoxifen45 51 29 1111.7TP53, SELE, BRCA2, BRCA1, BMP6
27methotrexate51 45 1110.6CDKN2A, BRCA1, SELE, ERCC1, BRCA2, BMP6
28gemcitabine45 51 1110.6SLC29A1, ERCC1, RRM2, TP53, BRCA1, CHEK2
29glutamine458.5BRCA2, BRCA1, BMP6, NCAM1, KCNJ3
30testosterone45 61 24 1111.5SELE, SMAD4, BRCA2, NCAM1, BRCA1, CDKN2A
31paraffin458.5NCAM1, TP53, BRCA1, SMAD4, CDKN2A, BRCA2
32thymidylate458.4ERCC1, CDKN2A, SLC29A1, TP53, RRM2, BRCA1
33phosphatidylinositol458.4IL7, BRCA1, BRCA2, BMP6, ERCC1, NCAM1
34nitric oxide45 24 1110.3SELE, FOXP3, IL7, BMP6, NCAM1, SLC29A1
35hydroxyurea45 51 1110.2CDKN2A, CHEK2, BRCA1, BRCA2, RRM2, TP53
36paclitaxel45 51 1110.2TP53, BMP6, BRCA1, BRCA2, SLC29A1, ERCC1
37dopamine45 29 24 1111.1BMP6, CDKN2A, NCAM1, KCNJ3, SELE, KCNA4
38cycloheximide458.1BRCA2, TP53, SELE, BRCA1, IL7, BMP6
39vincristine45 51 1110.1BRCA2, CDKN2A, ERCC1, NCAM1, TP53, BMP6
40alanine458.0CDKN2A, BMP6, SELE, BRCA1, SMAD4, CHEK2
41progesterone45 29 61 24 1112.0BRCA2, NCAM1, BMP6, IL7, BRCA1, TP53
42tyrosine457.8ERCC1, NCAM1, BMP6, IL7, CHEK2, RRM2
43retinoic acid45 248.7BRCA1, CDKN2A, TP53, BRCA2, NCAM1, BMP6
44vegf457.6CDKN2A, SMAD4, TP53, SELE, BRCA1, IL7
45oligonucleotide457.6SMAD4, TP53, CHEK2, CDKN2A, BRCA1, IL7
46estrogen457.5SMAD4, CDKN2A, TP53, BRCA2, BRCA1, BMP6
47serine457.5BRCA1, TP53, BMP6, SMAD4, CDKN2A, CHEK2
48thymidine45 248.5TP53, RRM2, BRCA1, IL7, BMP6, ERCC1
49cisplatin45 51 61 1110.5TP53, RRM2, CDKN2A, ERCC1, BMP6, CHEK2
50doxorubicin45 51 119.0IL7, CDKN2A, ERCC1, NCAM1, TP53, BMP6

GO Terms for genes affiliated with Pancreas Adenocarcinoma

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16Gene Ontology
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Cellular components related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2transcription factor TFIID complexGO:0056699.4ERCC1, TP53
3voltage-gated potassium channel complexGO:0080769.0KCNA3, KCNJ3, KCNA4
4protein complexGO:0432348.5TP53, BRCA2, BRCA1, FOXP3, CDKN2A
5nucleoplasmGO:0056547.4CDKN2A, SMAD4, TP53, RRM2, BRCA2, BRCA1
6cytoplasmGO:0057376.5SMAD4, TP53, RRM2, BRCA2, BRCA1, FOXP3

Biological processes related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:03506610.0BRCA1, FOXP3
2T cell lineage commitmentGO:00236010.0IL7, TP53
3embryonic organ developmentGO:0485689.9ERCC1, TP53
4SMAD protein signal transductionGO:0603959.7BMP6, SMAD4
5response to X-rayGO:0101659.7ERCC1, BRCA2, TP53
6nucleotide-excision repairGO:0062899.6ERCC1, BRCA2, TP53
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.6BRCA2, TP53
8response to gamma radiationGO:0103329.6TP53, BRCA2, CHEK2
9replicative senescenceGO:0903999.5CDKN2A, CHEK2, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, BRCA2, BRCA1
11cell agingGO:0075699.5BRCA2, TP53
12positive regulation of cell cycle arrestGO:0711589.4CDKN2A, BRCA1, TP53
13positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.4BMP6, SMAD4
14potassium ion transportGO:0068139.3KCNA3, KCNJ3, KCNA4
15negative regulation of cell growthGO:0303089.3CDKN2A, TP53, SMAD4
16cellular response to DNA damage stimulusGO:0069749.2TP53, BRCA1, CHEK2
17negative regulation of cell proliferationGO:0082859.2CDKN2A, FOXP3, TP53, SMAD4
18double-strand break repairGO:0063029.0ERCC1, CHEK2, BRCA1, BRCA2, TP53
19negative regulation of transcription, DNA-templatedGO:0458928.8SMAD4, TP53, BRCA1, FOXP3, CDKN2A
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, BMP6, FOXP3, BRCA1, TP53, SMAD4
21positive regulation of transcription, DNA-templatedGO:0458938.2SMAD4, TP53, BRCA2, BRCA1, CHEK2, FOXP3

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:0350359.8FOXP3, TP53
2NF-kappaB bindingGO:0510599.8CDKN2A, FOXP3
3MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
4ubiquitin protein ligase bindingGO:0316259.1TP53, BRCA1, CHEK2
5identical protein bindingGO:0428029.0NCAM1, CHEK2, TP53, SMAD4
6transcription regulatory region DNA bindingGO:0442129.0BRCA1, TP53, SMAD4
7protein bindingGO:0055155.5CDKN2A, KCNJ3, KCNA4, SMAD4, TP53, SELE

Products for genes affiliated with Pancreas Adenocarcinoma

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Sources for Pancreas Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet