MCID: PNC033
MIFTS: 48

Pancreas Adenocarcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Pancreas Adenocarcinoma

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Disease Ontology:9 A pancreatic carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to cholangiocarcinoma and pancreatic cancer. An important gene associated with Pancreas Adenocarcinoma is KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The compounds bpde and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, t cells and endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Pancreas Adenocarcinoma

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Pancreas Adenocarcinoma, Aliases & Descriptions:

Name: Pancreas Adenocarcinoma 31 9
 
Pancreatic Adenocarcinoma 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:4074
NCIt39 C8294

Related Diseases for Pancreas Adenocarcinoma

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Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.5NCAM1, TP53, SMAD4
2pancreatic cancer30.2SMAD4, BRCA2, NCAM1, CDKN2A, SLC29A1
3esophageal cancer29.8SMAD4, TP53, CHEK2, CDKN2A
4adenoma29.5SMAD4, TP53, BRCA1, ERCC1, CDKN2A
5adenocarcinoma28.8SLC29A1, KCNJ3, SMAD4, TP53, RRM2, BRCA2
6melanoma28.7TP53, BRCA2, CHEK2, FOXP3, IL7, BMP6
7colorectal cancer28.4SMAD4, SLC29A1, CDKN2A, ERCC1, BMP6, CHEK2
8pancreatitis11.4
9leukostasis10.5SELE
10breast-ovarian cancer, familial, 110.5BRCA2
11actinic keratosis10.4TP53
12cystadenoma10.3BRCA1
13peutz-jeghers syndrome10.3
14autoimmune pancreatitis10.3
15bile duct carcinoma10.3BRCA2, NCAM1
16colitis10.3SMAD4, FOXP3, IL7
17ovarian cystadenoma10.3SELE, BRCA1
18brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
19peritoneal carcinoma10.2BRCA2, BRCA1
20embryonal rhabdomyosarcoma10.2SMAD4, NCAM1
21fallopian tube cancer10.2BRCA2, BRCA1
22lynch syndrome10.2BRCA1, BRCA2
23male breast cancer10.2BRCA1, BRCA2
24atypical mole syndrome10.2BRCA2, CDKN2A
25dysgerminoma10.2BRCA1, BRCA2
26oropharyngeal cancer, adult10.2TP53, CDKN2A
27cystic fibrosis10.2
28hepatitis10.2
29esophagitis10.2
30prostatitis10.2
31chronic lymphocytic leukemia10.1ERCC1, IL7, BRCA2
32nijmegen breakage syndrome10.1BRCA1, CHEK2
33telangiectasis10.1SMAD4, BMP6
34cowden disease10.1BRCA1, BRCA2, SMAD4
35bilateral breast cancer10.1CHEK2, BRCA1, BRCA2
36nasopharynx carcinoma10.1CDKN2A, TP53
37xeroderma pigmentosum10.1TP53, BRCA1, ERCC1
38breast cancer, invasive ductal10.1BRCA1, TP53
39breast ductal carcinoma10.1BRCA1, TP53, SMAD4
40gynecomastia10.1BRCA2, BRCA1
41rhabdomyosarcoma10.1NCAM1, TP53, SMAD4
42hodgkin's lymphoma10.0BRCA2, BRCA1, IL7
43li-fraumeni syndrome10.0BRCA2, BRCA1
44pancreatic ductal adenocarcinoma10.0
45pancreatic acinar cell adenocarcinoma10.0
46cystic teratoma10.0
47peritonitis10.0
48endotheliitis10.0
49familial adenomatous polyposis10.0SMAD4, TP53, BRCA1
50ductal carcinoma in situ10.0BRCA1, BRCA2, TP53

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Symptoms for Pancreas Adenocarcinoma

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Drugs & Therapeutics for Pancreas Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

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Anatomical Context for Pancreas Adenocarcinoma

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MalaCards organs/tissues related to Pancreas Adenocarcinoma:

32
Pancreas, T cells, Endothelial

Animal Models for Pancreas Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8SLC29A1, CDKN2A, IL7, FOXP3, TP53
2MP:00053708.7SMAD4, TP53, SELE, FOXP3, ERCC1, CDKN2A
3MP:00053678.5SMAD4, TP53, BRCA1, FOXP3, ERCC1
4MP:00053698.5KCNA3, SMAD4, TP53, BRCA1, ERCC1, CDKN2A
5MP:00028738.3KCNA3, SMAD4, TP53, SELE, BRCA2, BRCA1
6MP:00053818.3SMAD4, TP53, BRCA2, BRCA1, FOXP3, CDKN2A
7MP:00020068.2SMAD4, TP53, BRCA2, BRCA1, CHEK2, ERCC1
8MP:00053798.2SMAD4, TP53, BRCA2, BRCA1, FOXP3, ERCC1
9MP:00053808.1SMAD4, TP53, BRCA2, BRCA1, ERCC1, CDKN2A
10MP:00107718.0SMAD4, TP53, SELE, BRCA2, BRCA1, FOXP3
11MP:00053908.0TP53, BRCA2, BRCA1, BMP6, ERCC1, CDKN2A
12MP:00053897.7SMAD4, TP53, BRCA2, BRCA1, FOXP3, BMP6
13MP:00053977.5BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
14MP:00053877.4BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
15MP:00053767.4KCNA3, SMAD4, TP53, SELE, BRCA2, BRCA1
16MP:00053847.3BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
17MP:00107687.3SMAD4, TP53, SELE, BRCA2, BRCA1, CHEK2
18MP:00036317.1KCNA4, SMAD4, TP53, BRCA2, BRCA1, NCAM1
19MP:00053786.7SLC29A1, KCNA3, SMAD4, TP53, SELE, BRCA2
20MP:00053866.6SELE, TP53, SMAD4, KCNA4, BRCA2, BRCA1

Publications for Pancreas Adenocarcinoma

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Articles related to Pancreas Adenocarcinoma:

(show all 20)
idTitleAuthorsYear
1
A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma. (24901360)
2014
2
Adjuvant therapy for pancreas adenocarcinoma. (22886586)
2013
3
FOLFIRINOX in locally advanced pancreas adenocarcinoma: back to the future? (23704222)
2013
4
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (22569992)
2013
5
Reply to an analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606044)
2013
6
Evolving panorama of treatment for metastatic pancreas adenocarcinoma. (23547071)
2013
7
Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression. (23360922)
2013
8
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606137)
2013
9
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. (21382702)
2012
10
Adjuvant therapy for pancreas adenocarcinoma: where are we going? (21342036)
2011
11
Differential expression of ERCC1 in pancreas adenocarcinoma: high tumor expression is associated with earlier recurrence and shortened survival after resection. (21360249)
2011
12
Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. (19851808)
2010
13
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. (19421880)
2009
14
Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]. (19548527)
2009
15
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. (19465885)
2009
16
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. (16799337)
2006
17
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. (15501974)
2004
18
Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. (11173546)
2001
19
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. (8797870)
1996
20
Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. (7804431)
1994

Variations for Pancreas Adenocarcinoma

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Expression for genes affiliated with Pancreas Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Pancreas Adenocarcinoma

Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

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Pathways related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA1, BRCA2
2
Show member pathways
9.7BRCA2, BRCA1
3
Show member pathways
9.7CHEK2, TP53
49.7CHEK2, TP53
59.6SLC29A1, RRM2
69.5BRCA1, TP53
79.5BRCA1, TP53
8
Show member pathways
9.5TP53, CDKN2A
99.5TP53, CDKN2A
109.5ERCC1, BRCA1, BRCA2
11
Show member pathways
9.5BRCA2, BRCA1, ERCC1
129.3SMAD4, TP53, BRCA1
13
Show member pathways
9.2TP53, BRCA1, CHEK2
14
Show member pathways
ATM Signaling Pathway37
9.2TP53, BRCA1, CHEK2
159.2CHEK2, BRCA1, TP53
169.2CHEK2, BRCA1, TP53
17
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2CHEK2, BRCA1, TP53
18
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.2CDKN2A, TP53, SMAD4
199.2CDKN2A, TP53, SMAD4
20
Show member pathways
9.1KCNA3, KCNJ3, KCNA4
21
Show member pathways
9.1SLC29A1, RRM2, TP53
22
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.0CDKN2A, CHEK2, BRCA1, SMAD4
238.9SMAD4, TP53, CHEK2, CDKN2A
24
Show member pathways
Cell cycle37
8.9CDKN2A, CHEK2, TP53, SMAD4
25
Show member pathways
8.9CDKN2A, RRM2, TP53
268.9CHEK2, BRCA1, BRCA2, TP53
27
Show member pathways
8.9CHEK2, BRCA1, BRCA2, TP53
288.8SMAD4, TP53, BRCA2, CDKN2A
29
Show member pathways
8.8SMAD4, TP53, BRCA2, CDKN2A
30
Show member pathways
Signaling Pathways in Glioblastoma37
8.7TP53, BRCA2, BRCA1, CDKN2A
31
Show member pathways
8.6TP53, BRCA2, BRCA1, CHEK2, ERCC1
328.6SMAD4, TP53, BRCA2, BRCA1, CHEK2
338.6SMAD4, TP53, BRCA2, BRCA1, CHEK2
34
Show member pathways
8.2CDKN2A, BMP6, BRCA1, BRCA2, TP53
35
Show member pathways
8.2CDKN2A, ERCC1, CHEK2, BRCA1, BRCA2, TP53
36
Show member pathways
DNA damage response37
8.2TP53, RRM2, BRCA1, CHEK2, CDKN2A
37
Show member pathways
8.2TP53, RRM2, BRCA1, CHEK2, CDKN2A
38
Show member pathways
8.0TP53, BRCA1, CHEK2, IL7, BMP6, CDKN2A

Compounds for genes affiliated with Pancreas Adenocarcinoma

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Compounds related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1bpde449.6CHEK2, BRCA1, TP53
2temozolomide44 1210.4TP53, CHEK2, CDKN2A
3okt3449.4BMP6, IL7, SELE
4bcnu449.4TP53, ERCC1, CDKN2A
55-methylcytosine44 2510.4CDKN2A, BRCA1, TP53
6lactacystin449.3TP53, SELE, BRCA1, ERCC1
7mitomycin c449.3TP53, BRCA2, BRCA1, ERCC1
8o6-methylguanine449.2TP53, BRCA2, CDKN2A
9rapamycin449.2CHEK2, FOXP3, IL7, BMP6, ERCC1
10hmba449.2CDKN2A, BMP6, TP53
11cyclophosphamide44 50 1211.2TP53, SELE, BRCA1, IL7, ERCC1
12aphidicolin449.1CHEK2, BRCA1, TP53
13gold449.1BRCA2, BRCA1, NCAM1, CDKN2A
14bleomycin44 1210.0BMP6, BRCA1, BRCA2, TP53
15cytarabine44 50 1210.9TP53, RRM2, CDKN2A, SLC29A1
16caffeine44 29 3 50 25 1213.9TP53, BRCA1, CHEK2, BMP6
17crcs448.9SMAD4, TP53, CDKN2A
18agar448.9SMAD4, BRCA1, IL7, BMP6, CDKN2A
19mg 13244 609.9SMAD4, TP53, BRCA1, CDKN2A
20docetaxel44 50 60 1211.9TP53, BRCA2, BRCA1, ERCC1, CDKN2A
21adriamycin448.8TP53, BRCA2, BRCA1, CHEK2, CDKN2A
22camptothecin44 60 1210.8TP53, BRCA2, BRCA1, CHEK2, CDKN2A
235fluorouracil448.8TP53, SELE, BRCA1, ERCC1, CDKN2A, SLC29A1
24etoposide44 50 60 1211.8TP53, SELE, BRCA2, BRCA1, CHEK2, ERCC1
25genistein44 29 60 3 25 1213.8SELE, BRCA2, BRCA1, CHEK2, IL7, CDKN2A
26tamoxifen44 50 29 1211.7TP53, SELE, BRCA2, BRCA1, BMP6
27methotrexate50 44 1210.6SELE, BRCA2, BRCA1, BMP6, ERCC1, CDKN2A
28gemcitabine44 50 1210.6TP53, RRM2, BRCA1, CHEK2, ERCC1, SLC29A1
29glutamine448.5NCAM1, BMP6, BRCA1, BRCA2, KCNJ3
30testosterone44 60 25 1211.5SMAD4, SELE, BRCA2, BRCA1, IL7, NCAM1
31paraffin448.5SMAD4, TP53, BRCA2, BRCA1, NCAM1, CDKN2A
32thymidylate448.4TP53, RRM2, BRCA1, ERCC1, CDKN2A, SLC29A1
33phosphatidylinositol448.4BRCA2, BRCA1, CHEK2, IL7, BMP6, NCAM1
34nitric oxide44 25 1210.3SMAD4, SELE, FOXP3, IL7, BMP6, NCAM1
35hydroxyurea44 50 1210.2TP53, RRM2, BRCA2, BRCA1, CHEK2, CDKN2A
36paclitaxel44 50 1210.2TP53, BRCA2, BRCA1, BMP6, ERCC1, CDKN2A
37dopamine44 29 25 1211.1KCNJ3, KCNA4, SELE, BMP6, NCAM1, CDKN2A
38cycloheximide448.1TP53, SELE, BRCA2, BRCA1, IL7, BMP6
39vincristine44 50 1210.1TP53, BRCA2, BRCA1, BMP6, NCAM1, ERCC1
40alanine448.0SMAD4, SELE, BRCA1, CHEK2, IL7, BMP6
41progesterone44 29 60 25 1212.0TP53, BRCA2, BRCA1, IL7, BMP6, NCAM1
42tyrosine447.8SMAD4, RRM2, BRCA1, CHEK2, IL7, BMP6
43retinoic acid44 258.7TP53, BRCA2, BRCA1, CHEK2, IL7, BMP6
44vegf447.6SMAD4, TP53, SELE, BRCA1, IL7, BMP6
45oligonucleotide447.6SMAD4, TP53, BRCA2, BRCA1, CHEK2, IL7
46estrogen447.5SMAD4, TP53, BRCA2, BRCA1, IL7, BMP6
47serine447.5SMAD4, TP53, SELE, BRCA1, CHEK2, IL7
48thymidine44 258.5SMAD4, TP53, RRM2, BRCA2, BRCA1, IL7
49cisplatin44 50 60 1210.5TP53, RRM2, BRCA2, BRCA1, CHEK2, BMP6
50doxorubicin44 50 129.0CDKN2A, TP53, SELE, RRM2, BRCA1, CHEK2

GO Terms for genes affiliated with Pancreas Adenocarcinoma

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Cellular components related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2transcription factor TFIID complexGO:0056699.4ERCC1, TP53
3voltage-gated potassium channel complexGO:0080769.0KCNA3, KCNJ3, KCNA4
4protein complexGO:0432348.5TP53, BRCA2, BRCA1, FOXP3, CDKN2A
5nucleoplasmGO:0056547.4CDKN2A, SMAD4, TP53, RRM2, BRCA2, BRCA1
6cytoplasmGO:0057376.5SMAD4, TP53, RRM2, BRCA2, BRCA1, FOXP3

Biological processes related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:03506610.0BRCA1, FOXP3
2T cell lineage commitmentGO:00236010.0IL7, TP53
3embryonic organ developmentGO:0485689.9ERCC1, TP53
4SMAD protein signal transductionGO:0603959.7BMP6, SMAD4
5response to X-rayGO:0101659.7ERCC1, BRCA2, TP53
6nucleotide-excision repairGO:0062899.6ERCC1, BRCA2, TP53
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.6BRCA2, TP53
8response to gamma radiationGO:0103329.6TP53, BRCA2, CHEK2
9replicative senescenceGO:0903999.5CDKN2A, CHEK2, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, BRCA2, BRCA1
11cell agingGO:0075699.5BRCA2, TP53
12positive regulation of cell cycle arrestGO:0711589.4CDKN2A, BRCA1, TP53
13positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.4BMP6, SMAD4
14potassium ion transportGO:0068139.3KCNA3, KCNJ3, KCNA4
15negative regulation of cell growthGO:0303089.3CDKN2A, TP53, SMAD4
16cellular response to DNA damage stimulusGO:0069749.2TP53, BRCA1, CHEK2
17negative regulation of cell proliferationGO:0082859.2CDKN2A, FOXP3, TP53, SMAD4
18double-strand break repairGO:0063029.0ERCC1, CHEK2, BRCA1, BRCA2, TP53
19negative regulation of transcription, DNA-templatedGO:0458928.8SMAD4, TP53, BRCA1, FOXP3, CDKN2A
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, BMP6, FOXP3, BRCA1, TP53, SMAD4
21positive regulation of transcription, DNA-templatedGO:0458938.2SMAD4, TP53, BRCA2, BRCA1, CHEK2, FOXP3

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:0350359.8FOXP3, TP53
2NF-kappaB bindingGO:0510599.8CDKN2A, FOXP3
3MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
4ubiquitin protein ligase bindingGO:0316259.1TP53, BRCA1, CHEK2
5identical protein bindingGO:0428029.0NCAM1, CHEK2, TP53, SMAD4
6transcription regulatory region DNA bindingGO:0442129.0BRCA1, TP53, SMAD4
7protein bindingGO:0055155.5CDKN2A, KCNJ3, KCNA4, SMAD4, TP53, SELE

Products for genes affiliated with Pancreas Adenocarcinoma

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Sources for Pancreas Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
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26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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51PubMed
52QIAGEN
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61UMLS
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