MCID: PNC033
MIFTS: 49

Pancreas Adenocarcinoma malady

Cancer diseases, Endocrine diseases categories
Download this MalaCard

Summaries for Pancreas Adenocarcinoma

About this section


Fully expand this MalaCard
Disease Ontology:8 A pancreatic carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to cholangiocarcinoma and pancreatic cancer. An important gene associated with Pancreas Adenocarcinoma is KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3), and among its related pathways are Homologous Recombination Repair and Fanconi anemia pathway. The compounds bpde and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, t cells and endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Pancreas Adenocarcinoma

About this section

Pancreas Adenocarcinoma, Aliases & Descriptions:

Name: Pancreas Adenocarcinoma 30 8
 
Pancreatic Adenocarcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:4074
NCIt39 C8294

Related Diseases for Pancreas Adenocarcinoma

About this section

Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.5NCAM1, TP53, SMAD4
2pancreatic cancer30.2SMAD4, BRCA2, NCAM1, CDKN2A, SLC29A1
3esophageal cancer29.8SMAD4, TP53, CHEK2, CDKN2A
4adenoma29.5SMAD4, TP53, BRCA1, ERCC1, CDKN2A
5adenocarcinoma28.8SLC29A1, KCNJ3, SMAD4, TP53, RRM2, BRCA2
6melanoma28.7TP53, BRCA2, CHEK2, FOXP3, IL7, BMP6
7colorectal cancer28.4SMAD4, SLC29A1, CDKN2A, ERCC1, BMP6, CHEK2
8pancreatitis11.4
9leukostasis10.5SELE
10breast-ovarian cancer, familial, 110.5BRCA2
11actinic keratosis10.4TP53
12cystadenoma10.3BRCA1
13peutz-jeghers syndrome10.3
14autoimmune pancreatitis10.3
15bile duct carcinoma10.3BRCA2, NCAM1
16colitis10.3SMAD4, FOXP3, IL7
17ovarian cystadenoma10.3SELE, BRCA1
18brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
19peritoneal carcinoma10.2BRCA2, BRCA1
20embryonal rhabdomyosarcoma10.2SMAD4, NCAM1
21fallopian tube cancer10.2BRCA2, BRCA1
22lynch syndrome10.2BRCA1, BRCA2
23male breast cancer10.2BRCA1, BRCA2
24atypical mole syndrome10.2BRCA2, CDKN2A
25dysgerminoma10.2BRCA1, BRCA2
26oropharyngeal cancer, adult10.2TP53, CDKN2A
27cystic fibrosis10.2
28hepatitis10.2
29esophagitis10.2
30prostatitis10.2
31chronic lymphocytic leukemia10.1ERCC1, IL7, BRCA2
32nijmegen breakage syndrome10.1BRCA1, CHEK2
33telangiectasis10.1SMAD4, BMP6
34cowden disease10.1BRCA1, BRCA2, SMAD4
35bilateral breast cancer10.1CHEK2, BRCA1, BRCA2
36nasopharynx carcinoma10.1CDKN2A, TP53
37xeroderma pigmentosum10.1TP53, BRCA1, ERCC1
38breast cancer, invasive ductal10.1BRCA1, TP53
39breast ductal carcinoma10.1BRCA1, TP53, SMAD4
40gynecomastia10.1BRCA2, BRCA1
41rhabdomyosarcoma10.1NCAM1, TP53, SMAD4
42hodgkin's lymphoma10.0BRCA2, BRCA1, IL7
43li-fraumeni syndrome10.0BRCA2, BRCA1
44pancreatic ductal adenocarcinoma10.0
45pancreatic acinar cell adenocarcinoma10.0
46cystic teratoma10.0
47peritonitis10.0
48endotheliitis10.0
49familial adenomatous polyposis10.0SMAD4, TP53, BRCA1
50ductal carcinoma in situ10.0BRCA1, BRCA2, TP53

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Symptoms for Pancreas Adenocarcinoma

About this section

Drugs & Therapeutics for Pancreas Adenocarcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

About this section

Anatomical Context for Pancreas Adenocarcinoma

About this section

MalaCards organs/tissues related to Pancreas Adenocarcinoma:

32
Pancreas, T cells, Endothelial

Animal Models for Pancreas Adenocarcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8SLC29A1, CDKN2A, IL7, FOXP3, TP53
2MP:00053708.7SMAD4, TP53, SELE, FOXP3, ERCC1, CDKN2A
3MP:00053678.5SMAD4, TP53, BRCA1, FOXP3, ERCC1
4MP:00053698.5KCNA3, SMAD4, TP53, BRCA1, ERCC1, CDKN2A
5MP:00028738.3KCNA3, SMAD4, TP53, SELE, BRCA2, BRCA1
6MP:00053818.3SMAD4, TP53, BRCA2, BRCA1, FOXP3, CDKN2A
7MP:00020068.2SMAD4, TP53, BRCA2, BRCA1, CHEK2, ERCC1
8MP:00053798.2SMAD4, TP53, BRCA2, BRCA1, FOXP3, ERCC1
9MP:00053808.1SMAD4, TP53, BRCA2, BRCA1, ERCC1, CDKN2A
10MP:00107718.0SMAD4, TP53, SELE, BRCA2, BRCA1, FOXP3
11MP:00053908.0TP53, BRCA2, BRCA1, BMP6, ERCC1, CDKN2A
12MP:00053897.7SMAD4, TP53, BRCA2, BRCA1, FOXP3, BMP6
13MP:00053977.5BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
14MP:00053877.4BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
15MP:00053767.4KCNA3, SMAD4, TP53, SELE, BRCA2, BRCA1
16MP:00053847.3BRCA2, SELE, TP53, SMAD4, BRCA1, CHEK2
17MP:00107687.3SMAD4, TP53, SELE, BRCA2, BRCA1, CHEK2
18MP:00036317.1KCNA4, SMAD4, TP53, BRCA2, BRCA1, NCAM1
19MP:00053786.7SLC29A1, KCNA3, SMAD4, TP53, SELE, BRCA2
20MP:00053866.6SELE, TP53, SMAD4, KCNA4, BRCA2, BRCA1

Publications for Pancreas Adenocarcinoma

About this section

Articles related to Pancreas Adenocarcinoma:

(show all 20)
idTitleAuthorsYear
1
A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma. (24901360)
2014
2
Adjuvant therapy for pancreas adenocarcinoma. (22886586)
2013
3
FOLFIRINOX in locally advanced pancreas adenocarcinoma: back to the future? (23704222)
2013
4
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (22569992)
2013
5
Reply to an analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606044)
2013
6
Evolving panorama of treatment for metastatic pancreas adenocarcinoma. (23547071)
2013
7
Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression. (23360922)
2013
8
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606137)
2013
9
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. (21382702)
2012
10
Adjuvant therapy for pancreas adenocarcinoma: where are we going? (21342036)
2011
11
Differential expression of ERCC1 in pancreas adenocarcinoma: high tumor expression is associated with earlier recurrence and shortened survival after resection. (21360249)
2011
12
Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. (19851808)
2010
13
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. (19421880)
2009
14
Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]. (19548527)
2009
15
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. (19465885)
2009
16
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. (16799337)
2006
17
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. (15501974)
2004
18
Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. (11173546)
2001
19
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. (8797870)
1996
20
Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. (7804431)
1994

Variations for Pancreas Adenocarcinoma

About this section

Expression for genes affiliated with Pancreas Adenocarcinoma

About this section
Expression patterns in normal tissues for genes affiliated with Pancreas Adenocarcinoma

Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

About this section

Pathways related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA2, BRCA1
2
Show member pathways
9.7BRCA2, BRCA1
39.7CHEK2, TP53
4
Show member pathways
9.7TP53, CHEK2
59.6RRM2, SLC29A1
69.5BRCA1, TP53
79.5TP53, BRCA1
89.5TP53, CDKN2A
9
Show member pathways
9.5TP53, CDKN2A
10
Show member pathways
9.5BRCA1, ERCC1, BRCA2
119.5ERCC1, BRCA1, BRCA2
129.3TP53, SMAD4, BRCA1
13
Show member pathways
9.2CHEK2, BRCA1, TP53
14
Show member pathways
ATM Signaling Pathway37
9.2BRCA1, CHEK2, TP53
159.2BRCA1, CHEK2, TP53
169.2TP53, BRCA1, CHEK2
17
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2TP53, CHEK2, BRCA1
18
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.2TP53, SMAD4, CDKN2A
199.2TP53, CDKN2A, SMAD4
20
Show member pathways
9.1KCNJ3, KCNA4, KCNA3
21
Show member pathways
9.1SLC29A1, TP53, RRM2
22
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.0CHEK2, BRCA1, CDKN2A, SMAD4
238.9TP53, SMAD4, CDKN2A, CHEK2
24
Show member pathways
Cell cycle37
8.9TP53, SMAD4, CDKN2A, CHEK2
25
Show member pathways
8.9TP53, RRM2, CDKN2A
268.9BRCA1, CHEK2, TP53, BRCA2
27
Show member pathways
8.9TP53, BRCA2, BRCA1, CHEK2
28
Show member pathways
8.8TP53, SMAD4, CDKN2A, BRCA2
298.8BRCA2, TP53, SMAD4, CDKN2A
30
Show member pathways
Signaling Pathways in Glioblastoma37
8.7BRCA1, BRCA2, TP53, CDKN2A
31
Show member pathways
8.6ERCC1, TP53, BRCA2, BRCA1, CHEK2
328.6CHEK2, BRCA1, TP53, SMAD4, BRCA2
338.6BRCA2, CHEK2, BRCA1, SMAD4, TP53
34
Show member pathways
8.2BRCA2, TP53, CDKN2A, BRCA1, BMP6
35
Show member pathways
8.2CDKN2A, TP53, BRCA2, BRCA1, CHEK2, ERCC1
36
Show member pathways
8.2CHEK2, BRCA1, RRM2, TP53, CDKN2A
37
Show member pathways
DNA damage response37
8.2RRM2, TP53, CDKN2A, CHEK2, BRCA1
38
Show member pathways
8.0IL7, TP53, BRCA1, BMP6, CDKN2A, CHEK2

Compounds for genes affiliated with Pancreas Adenocarcinoma

About this section

Compounds related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1bpde449.6TP53, CHEK2, BRCA1
2temozolomide44 1110.4CDKN2A, CHEK2, TP53
3bcnu449.4TP53, ERCC1, CDKN2A
45-methylcytosine44 2410.4CDKN2A, TP53, BRCA1
5lactacystin449.3SELE, ERCC1, TP53, BRCA1
6okt3449.3BMP6, IL7, SELE
7mitomycin c449.3ERCC1, BRCA1, TP53, BRCA2
8aphidicolin449.2TP53, BRCA1, CHEK2
9o6-methylguanine449.2CDKN2A, BRCA2, TP53
10rapamycin449.2IL7, ERCC1, CHEK2, FOXP3, BMP6
11hmba449.2TP53, CDKN2A, BMP6
12cyclophosphamide44 50 1111.2ERCC1, IL7, SELE, TP53, BRCA1
13gold449.1NCAM1, CDKN2A, BRCA2, BRCA1
14bleomycin44 1110.0BRCA1, BMP6, BRCA2, TP53
15cytarabine44 50 1110.9SLC29A1, CDKN2A, RRM2, TP53
16caffeine44 28 2 50 24 1113.9BMP6, CHEK2, BRCA1, TP53
17crcs448.9CDKN2A, SMAD4, TP53
18agar448.9IL7, BMP6, BRCA1, SMAD4, CDKN2A
19mg 13244 619.9SMAD4, CDKN2A, BRCA1, TP53
20docetaxel44 50 61 1111.9ERCC1, BRCA2, TP53, CDKN2A, BRCA1
21adriamycin448.8BRCA2, BRCA1, TP53, CDKN2A, CHEK2
22camptothecin44 61 1110.8CDKN2A, CHEK2, BRCA1, BRCA2, TP53
235fluorouracil448.8SLC29A1, BRCA1, ERCC1, SELE, TP53, CDKN2A
24etoposide44 50 61 1111.8SELE, BRCA1, ERCC1, CHEK2, BRCA2, TP53
25genistein44 28 61 2 24 1113.8BRCA1, BRCA2, CDKN2A, CHEK2, IL7, SELE
26tamoxifen44 50 28 1111.7TP53, SELE, BRCA2, BRCA1, BMP6
27methotrexate50 44 1110.6CDKN2A, BRCA1, SELE, ERCC1, BRCA2, BMP6
28gemcitabine44 50 1110.6SLC29A1, ERCC1, RRM2, TP53, BRCA1, CHEK2
29glutamine448.5BRCA2, BRCA1, BMP6, NCAM1, KCNJ3
30testosterone44 61 24 1111.5SELE, SMAD4, BRCA2, NCAM1, BRCA1, CDKN2A
31paraffin448.5NCAM1, TP53, BRCA1, SMAD4, CDKN2A, BRCA2
32thymidylate448.4ERCC1, CDKN2A, SLC29A1, TP53, RRM2, BRCA1
33phosphatidylinositol448.4IL7, BRCA1, BRCA2, BMP6, ERCC1, NCAM1
34nitric oxide44 24 1110.3SELE, FOXP3, IL7, BMP6, NCAM1, SLC29A1
35hydroxyurea44 50 1110.2CDKN2A, CHEK2, BRCA1, BRCA2, RRM2, TP53
36paclitaxel44 50 1110.2TP53, BMP6, BRCA1, BRCA2, SLC29A1, ERCC1
37dopamine44 28 24 1111.1BMP6, CDKN2A, NCAM1, KCNJ3, SELE, KCNA4
38cycloheximide448.1BRCA2, TP53, SELE, BRCA1, IL7, BMP6
39vincristine44 50 1110.1BRCA2, CDKN2A, ERCC1, NCAM1, TP53, BMP6
40alanine448.0CDKN2A, BMP6, SELE, BRCA1, SMAD4, CHEK2
41progesterone44 28 61 24 1112.0BRCA2, NCAM1, BMP6, IL7, BRCA1, TP53
42tyrosine447.8ERCC1, NCAM1, BMP6, IL7, CHEK2, RRM2
43retinoic acid44 248.7BRCA1, CDKN2A, TP53, BRCA2, NCAM1, BMP6
44vegf447.6CDKN2A, SMAD4, TP53, SELE, BRCA1, IL7
45oligonucleotide447.6SMAD4, TP53, CHEK2, CDKN2A, BRCA1, IL7
46estrogen447.5SMAD4, CDKN2A, TP53, BRCA2, BRCA1, BMP6
47serine447.5BRCA1, TP53, BMP6, SMAD4, CDKN2A, CHEK2
48thymidine44 248.5TP53, RRM2, BRCA1, IL7, BMP6, ERCC1
49cisplatin44 50 61 1110.5TP53, RRM2, CDKN2A, ERCC1, BMP6, CHEK2
50doxorubicin44 50 119.0IL7, CDKN2A, ERCC1, NCAM1, TP53, BMP6

GO Terms for genes affiliated with Pancreas Adenocarcinoma

About this section

Cellular components related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2transcription factor TFIID complexGO:0056699.4TP53, ERCC1
3voltage-gated potassium channel complexGO:0080769.0KCNJ3, KCNA3, KCNA4
4protein complexGO:0432348.5BRCA2, BRCA1, FOXP3, CDKN2A, TP53
5nucleoplasmGO:0056547.4CDKN2A, SMAD4, TP53, RRM2, BRCA2, BRCA1
6cytoplasmGO:0057376.5BMP6, CDKN2A, ERCC1, BRCA1, SMAD4, TP53

Biological processes related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:03506610.0FOXP3, BRCA1
2T cell lineage commitmentGO:00236010.0TP53, IL7
3embryonic organ developmentGO:0485689.9ERCC1, TP53
4SMAD protein signal transductionGO:0603959.7BMP6, SMAD4
5response to X-rayGO:0101659.7ERCC1, TP53, BRCA2
6nucleotide-excision repairGO:0062899.6ERCC1, TP53, BRCA2
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.6BRCA2, TP53
8response to gamma radiationGO:0103329.6BRCA2, CHEK2, TP53
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.6BMP6, SMAD4
10replicative senescenceGO:0903999.5TP53, CDKN2A, CHEK2
11DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5BRCA1, TP53, BRCA2
12positive regulation of cell cycle arrestGO:0711589.4TP53, BRCA1, CDKN2A
13potassium ion transportGO:0068139.3KCNJ3, KCNA3, KCNA4
14negative regulation of cell growthGO:0303089.3SMAD4, CDKN2A, TP53
15cell agingGO:0075699.3TP53, BRCA2
16cellular response to DNA damage stimulusGO:0069749.2BRCA1, TP53, CHEK2
17negative regulation of cell proliferationGO:0082859.2CDKN2A, SMAD4, FOXP3, TP53
18double-strand break repairGO:0063029.0BRCA2, TP53, BRCA1, CHEK2, ERCC1
19negative regulation of transcription, DNA-templatedGO:0458928.8FOXP3, CDKN2A, SMAD4, TP53, BRCA1
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.3FOXP3, BMP6, CDKN2A, BRCA1, TP53, SMAD4
21positive regulation of transcription, DNA-templatedGO:0458938.2TP53, SMAD4, FOXP3, CHEK2, CDKN2A, BRCA2

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:0350359.8FOXP3, TP53
2NF-kappaB bindingGO:0510599.8CDKN2A, FOXP3
3MDM2/MDM4 family protein bindingGO:0973719.6CDKN2A, TP53
4ubiquitin protein ligase bindingGO:0316259.1TP53, CHEK2, BRCA1
5identical protein bindingGO:0428029.0NCAM1, CHEK2, TP53, SMAD4
6transcription regulatory region DNA bindingGO:0442129.0TP53, SMAD4, BRCA1
7protein bindingGO:0055155.5CDKN2A, KCNJ3, KCNA4, SMAD4, TP53, SELE

Products for genes affiliated with Pancreas Adenocarcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Pancreas Adenocarcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet