MCID: PNC033
MIFTS: 41

Pancreas Adenocarcinoma malady

Endocrine diseases category

Aliases & Classifications for Pancreas Adenocarcinoma

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Pancreas Adenocarcinoma, Aliases & Descriptions:

Name: Pancreas Adenocarcinoma 30 9
 
Pancreatic Adenocarcinoma 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:4074
NCIt38 C8294

Summaries for Pancreas Adenocarcinoma

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Disease Ontology:9 A pancreatic carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to cholangiocarcinoma and pancreatic cancer. An important gene associated with Pancreas Adenocarcinoma is KCNA3 (potassium voltage-gated channel, shaker-related subfamily, member 3), and among its related pathways are Homologous Recombination Repair and Fanconi anemia pathway. The compounds bpde and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, t cells and endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Related Diseases for Pancreas Adenocarcinoma

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Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.5NCAM1, TP53, SMAD4
2pancreatic cancer30.3BRCA2, NCAM1, SMAD4, SLC29A1, CDKN2A
3hodgkin lymphoma30.1IL7, BRCA2, BRCA1
4esophageal cancer29.8SMAD4, TP53, CDKN2A, CHEK2
5adenoma29.5ERCC1, BRCA1, SMAD4, CDKN2A, TP53
6hepatocellular carcinoma28.9BRCA2, BMP6, SMAD4, FOXP3, CDKN2A, ERCC1
7adenocarcinoma28.8BMP6, SLC29A1, CDKN2A, ERCC1, NCAM1, RRM2
8melanoma28.7CHEK2, FOXP3, IL7, BMP6, TP53, BRCA2
9colorectal cancer28.4SLC29A1, CDKN2A, ERCC1, BMP6, BRCA1, CHEK2
10pancreatitis11.4
11leukostasis10.5SELE
12hereditary breast ovarian cancer10.5BRCA2
13actinic keratosis10.4TP53
14cystadenoma10.3BRCA1
15peutz-jeghers syndrome10.3
16autoimmune pancreatitis10.3
17bile duct carcinoma10.3BRCA2, NCAM1
18colitis10.3FOXP3, SMAD4, IL7
19ovarian cystadenoma10.3BRCA1, SELE
20brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
21peritoneal carcinoma10.2BRCA1, BRCA2
22embryonal rhabdomyosarcoma10.2SMAD4, NCAM1
23fallopian tube cancer10.2BRCA1, BRCA2
24lynch syndrome10.2BRCA2, BRCA1
25dysplastic nevus syndrome10.2CDKN2A, BRCA2
26dysgerminoma10.2BRCA2, BRCA1
27cystic fibrosis10.2
28insulin-like growth factor i10.2
29hepatitis10.2
30esophagitis10.2
31prostatitis10.2
32oropharynx cancer10.2TP53, CDKN2A
33chronic lymphocytic leukemia10.1ERCC1, BRCA2, IL7
34nijmegen breakage syndrome10.1BRCA1, CHEK2
35telangiectasis10.1SMAD4, BMP6
36cowden disease10.1BRCA2, BRCA1, SMAD4
37nasopharynx carcinoma10.1TP53, CDKN2A
38bilateral breast cancer10.1CHEK2, BRCA2, BRCA1
39xeroderma pigmentosum, variant type10.1ERCC1, BRCA1, TP53
40gynecomastia10.1BRCA1, BRCA2
41breast cancer10.1TP53, BRCA1
42breast ductal carcinoma10.1TP53, BRCA1, SMAD4
43rhabdomyosarcoma10.1NCAM1, SMAD4, TP53
44pancreatic ductal adenocarcinoma10.0
45pancreatic acinar cell adenocarcinoma10.0
46cystic teratoma10.0
47peritonitis10.0
48endotheliitis10.0
49bloom syndrome10.0BRCA2, BRCA1
50adenomatous polyposis coli10.0BRCA1, TP53, SMAD4

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Symptoms for Pancreas Adenocarcinoma

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Drugs & Therapeutics for Pancreas Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

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Anatomical Context for Pancreas Adenocarcinoma

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MalaCards organs/tissues related to Pancreas Adenocarcinoma:

31
Pancreas, T cells, Endothelial

Animal Models for Pancreas Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8TP53, SLC29A1, IL7, FOXP3, CDKN2A
2MP:00053708.7ERCC1, CDKN2A, FOXP3, SELE, TP53, SMAD4
3MP:00053678.5ERCC1, FOXP3, BRCA1, TP53, SMAD4
4MP:00053698.5SMAD4, TP53, KCNA3, BRCA1, CDKN2A, ERCC1
5MP:00028738.3SELE, TP53, SMAD4, KCNA3, BRCA2, BRCA1
6MP:00053818.3SMAD4, CDKN2A, FOXP3, BRCA2, TP53, BRCA1
7MP:00020068.2BRCA2, BRCA1, SMAD4, ERCC1, CHEK2, TP53
8MP:00053798.2CDKN2A, ERCC1, FOXP3, BRCA1, BRCA2, TP53
9MP:00053808.1SMAD4, CDKN2A, ERCC1, TP53, BRCA2, BRCA1
10MP:00107718.0SMAD4, TP53, SELE, FOXP3, ERCC1, CDKN2A
11MP:00053908.0TP53, CDKN2A, BRCA1, BMP6, ERCC1, BRCA2
12MP:00053897.7CDKN2A, BMP6, BRCA1, SMAD4, TP53, BRCA2
13MP:00053977.5CDKN2A, ERCC1, FOXP3, CHEK2, IL7, BRCA1
14MP:00053877.4SELE, SMAD4, TP53, BRCA1, BRCA2, CHEK2
15MP:00053767.4KCNA3, TP53, CDKN2A, ERCC1, FOXP3, BRCA1
16MP:00053847.3ERCC1, BRCA1, SELE, SMAD4, TP53, FOXP3
17MP:00107687.3NCAM1, BRCA1, FOXP3, CHEK2, SMAD4, TP53
18MP:00036317.1KCNA4, TP53, BRCA2, BRCA1, NCAM1, CDKN2A
19MP:00053786.7BRCA1, FOXP3, NCAM1, SELE, TP53, SMAD4
20MP:00053866.6SMAD4, SELE, CDKN2A, TP53, BRCA2, BRCA1

Publications for Pancreas Adenocarcinoma

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Articles related to Pancreas Adenocarcinoma:

(show all 22)
idTitleAuthorsYear
1
Novel directions in neoadjuvant therapy for pancreas adenocarcinoma. (25686370)
2015
2
Adjuvant and neoadjuvant systemic therapy for pancreas adenocarcinoma. (25726058)
2015
3
A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma. (24901360)
2014
4
Adjuvant therapy for pancreas adenocarcinoma. (22886586)
2013
5
FOLFIRINOX in locally advanced pancreas adenocarcinoma: back to the future? (23704222)
2013
6
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (22569992)
2013
7
Reply to an analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606044)
2013
8
Evolving panorama of treatment for metastatic pancreas adenocarcinoma. (23547071)
2013
9
Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression. (23360922)
2013
10
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606137)
2013
11
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. (21382702)
2012
12
Adjuvant therapy for pancreas adenocarcinoma: where are we going? (21342036)
2011
13
Differential expression of ERCC1 in pancreas adenocarcinoma: high tumor expression is associated with earlier recurrence and shortened survival after resection. (21360249)
2011
14
Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. (19851808)
2010
15
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. (19421880)
2009
16
Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]. (19548527)
2009
17
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. (19465885)
2009
18
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. (16799337)
2006
19
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. (15501974)
2004
20
Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. (11173546)
2001
21
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. (8797870)
1996
22
Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. (7804431)
1994

Variations for Pancreas Adenocarcinoma

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Expression for genes affiliated with Pancreas Adenocarcinoma

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Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

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Pathways related to Pancreas Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA2, BRCA1
2
Show member pathways
9.7BRCA2, BRCA1
39.7CHEK2, TP53
4
Show member pathways
9.7TP53, CHEK2
59.6RRM2, SLC29A1
69.5BRCA1, TP53
79.5TP53, BRCA1
89.5TP53, CDKN2A
9
Show member pathways
9.5TP53, CDKN2A
10
Show member pathways
9.5BRCA1, ERCC1, BRCA2
119.5ERCC1, BRCA1, BRCA2
12
Show member pathways
9.2CHEK2, BRCA1, TP53
13
Show member pathways
ATM Signaling Pathway36
9.2BRCA1, CHEK2, TP53
149.2BRCA1, CHEK2, TP53
159.2TP53, BRCA1, CHEK2
16
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2TP53, CHEK2, BRCA1
17
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.2TP53, SMAD4, CDKN2A
189.2TP53, CDKN2A, SMAD4
19
Show member pathways
9.1KCNJ3, KCNA4, KCNA3
20
Show member pathways
9.1SLC29A1, TP53, RRM2
21
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.0CHEK2, BRCA1, CDKN2A, SMAD4
228.9TP53, SMAD4, CDKN2A, CHEK2
23
Show member pathways
Cell cycle36
8.9TP53, SMAD4, CDKN2A, CHEK2
24
Show member pathways
8.9TP53, RRM2, CDKN2A
258.9BRCA1, CHEK2, TP53, BRCA2
26
Show member pathways
8.9TP53, BRCA2, BRCA1, CHEK2
27
Show member pathways
8.8TP53, SMAD4, CDKN2A, BRCA2
288.8BRCA2, TP53, SMAD4, CDKN2A
29
Show member pathways
Signaling Pathways in Glioblastoma36
8.7BRCA1, BRCA2, TP53, CDKN2A
30
Show member pathways
8.6ERCC1, TP53, BRCA2, BRCA1, CHEK2
318.6CHEK2, BRCA1, TP53, SMAD4, BRCA2
328.6BRCA2, CHEK2, BRCA1, SMAD4, TP53
33
Show member pathways
8.2BRCA2, TP53, CDKN2A, BRCA1, BMP6
34
Show member pathways
8.2CDKN2A, TP53, BRCA2, BRCA1, CHEK2, ERCC1
35
Show member pathways
8.2CHEK2, BRCA1, RRM2, TP53, CDKN2A
36
Show member pathways
DNA damage response36
8.2RRM2, TP53, CDKN2A, CHEK2, BRCA1
37
Show member pathways
8.0IL7, TP53, BRCA1, BMP6, CDKN2A, CHEK2

Compounds for genes affiliated with Pancreas Adenocarcinoma

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Compounds related to Pancreas Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1bpde439.6TP53, CHEK2, BRCA1
2temozolomide43 1210.4CDKN2A, CHEK2, TP53
3bcnu439.4TP53, ERCC1, CDKN2A
45-methylcytosine43 2410.4CDKN2A, TP53, BRCA1
5lactacystin439.3SELE, ERCC1, TP53, BRCA1
6okt3439.3BMP6, IL7, SELE
7mitomycin c439.3ERCC1, BRCA1, TP53, BRCA2
8aphidicolin439.2TP53, BRCA1, CHEK2
9o6-methylguanine439.2CDKN2A, BRCA2, TP53
10rapamycin439.2IL7, ERCC1, CHEK2, FOXP3, BMP6
11hmba439.2TP53, CDKN2A, BMP6
12cyclophosphamide43 49 1211.2ERCC1, IL7, SELE, TP53, BRCA1
13gold439.1NCAM1, CDKN2A, BRCA2, BRCA1
14bleomycin43 1210.0BRCA1, BMP6, BRCA2, TP53
15cytarabine43 49 1210.9SLC29A1, CDKN2A, RRM2, TP53
16caffeine43 28 2 49 24 1213.9BMP6, CHEK2, BRCA1, TP53
17crcs438.9CDKN2A, SMAD4, TP53
18agar438.9IL7, BMP6, BRCA1, SMAD4, CDKN2A
19mg 13243 599.9SMAD4, CDKN2A, BRCA1, TP53
20docetaxel43 49 59 1211.9ERCC1, BRCA2, TP53, CDKN2A, BRCA1
21adriamycin438.8BRCA2, BRCA1, TP53, CDKN2A, CHEK2
22camptothecin43 59 1210.8CDKN2A, CHEK2, BRCA1, BRCA2, TP53
235fluorouracil438.8SLC29A1, BRCA1, ERCC1, SELE, TP53, CDKN2A
24etoposide43 49 59 1211.8SELE, BRCA1, ERCC1, CHEK2, BRCA2, TP53
25genistein43 28 59 2 24 1213.8BRCA1, BRCA2, CDKN2A, CHEK2, IL7, SELE
26tamoxifen43 49 28 1211.7TP53, SELE, BRCA2, BRCA1, BMP6
27methotrexate49 43 1210.6CDKN2A, BRCA1, SELE, ERCC1, BRCA2, BMP6
28gemcitabine43 49 1210.6SLC29A1, ERCC1, RRM2, TP53, BRCA1, CHEK2
29glutamine438.5BRCA2, BRCA1, BMP6, NCAM1, KCNJ3
30testosterone43 59 24 1211.5SELE, SMAD4, BRCA2, NCAM1, BRCA1, CDKN2A
31paraffin438.5NCAM1, TP53, BRCA1, SMAD4, CDKN2A, BRCA2
32thymidylate438.4ERCC1, CDKN2A, SLC29A1, TP53, RRM2, BRCA1
33phosphatidylinositol438.4IL7, BRCA1, BRCA2, BMP6, ERCC1, NCAM1
34nitric oxide43 24 1210.3SELE, FOXP3, IL7, BMP6, NCAM1, SLC29A1
35hydroxyurea43 49 1210.2CDKN2A, CHEK2, BRCA1, BRCA2, RRM2, TP53
36paclitaxel43 49 1210.2TP53, BMP6, BRCA1, BRCA2, SLC29A1, ERCC1
37dopamine43 28 24 1211.1BMP6, CDKN2A, NCAM1, KCNJ3, SELE, KCNA4
38cycloheximide438.1BRCA2, TP53, SELE, BRCA1, IL7, BMP6
39vincristine43 49 1210.1BRCA2, CDKN2A, ERCC1, NCAM1, TP53, BMP6
40alanine438.0CDKN2A, BMP6, SELE, BRCA1, SMAD4, CHEK2
41progesterone43 28 59 24 1212.0BRCA2, NCAM1, BMP6, IL7, BRCA1, TP53
42tyrosine437.8ERCC1, NCAM1, BMP6, IL7, CHEK2, RRM2
43retinoic acid43 248.7BRCA1, CDKN2A, TP53, BRCA2, NCAM1, BMP6
44vegf437.6CDKN2A, SMAD4, TP53, SELE, BRCA1, IL7
45oligonucleotide437.6SMAD4, TP53, CHEK2, CDKN2A, BRCA1, IL7
46estrogen437.5SMAD4, CDKN2A, TP53, BRCA2, BRCA1, BMP6
47serine437.5BRCA1, TP53, BMP6, SMAD4, CDKN2A, CHEK2
48thymidine43 248.5TP53, RRM2, BRCA1, IL7, BMP6, ERCC1
49cisplatin43 49 59 1210.5TP53, RRM2, CDKN2A, ERCC1, BMP6, CHEK2
50doxorubicin43 49 129.0IL7, CDKN2A, ERCC1, NCAM1, TP53, BMP6

GO Terms for genes affiliated with Pancreas Adenocarcinoma

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Cellular components related to Pancreas Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5CDKN2A, TP53
2transcription factor TFIID complexGO:00056699.4ERCC1, TP53
3voltage-gated potassium channel complexGO:00080769.0KCNA3, KCNJ3, KCNA4
4protein complexGO:00432348.5TP53, BRCA2, BRCA1, FOXP3, CDKN2A
5nucleoplasmGO:00056547.4CDKN2A, SMAD4, TP53, RRM2, BRCA2, BRCA1
6cytoplasmGO:00057376.5SMAD4, TP53, RRM2, BRCA2, BRCA1, FOXP3

Biological processes related to Pancreas Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:003506610.0BRCA1, FOXP3
2T cell lineage commitmentGO:000236010.0IL7, TP53
3embryonic organ developmentGO:00485689.9ERCC1, TP53
4SMAD protein signal transductionGO:00603959.7BMP6, SMAD4
5response to X-rayGO:00101659.7ERCC1, BRCA2, TP53
6nucleotide-excision repairGO:00062899.6ERCC1, BRCA2, TP53
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.6BRCA2, TP53
8response to gamma radiationGO:00103329.6TP53, BRCA2, CHEK2
9replicative senescenceGO:00903999.5CDKN2A, CHEK2, TP53
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.5TP53, BRCA2, BRCA1
11cell agingGO:00075699.5BRCA2, TP53
12positive regulation of cell cycle arrestGO:00711589.4CDKN2A, BRCA1, TP53
13positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.4BMP6, SMAD4
14potassium ion transportGO:00068139.3KCNA3, KCNJ3, KCNA4
15negative regulation of cell growthGO:00303089.3CDKN2A, TP53, SMAD4
16cellular response to DNA damage stimulusGO:00069749.2TP53, BRCA1, CHEK2
17negative regulation of cell proliferationGO:00082859.2CDKN2A, FOXP3, TP53, SMAD4
18double-strand break repairGO:00063029.0ERCC1, CHEK2, BRCA1, BRCA2, TP53
19negative regulation of transcription, DNA-templatedGO:00458928.8SMAD4, TP53, BRCA1, FOXP3, CDKN2A
20positive regulation of transcription from RNA polymerase II promoterGO:00459448.3CDKN2A, BMP6, FOXP3, BRCA1, TP53, SMAD4
21positive regulation of transcription, DNA-templatedGO:00458938.2SMAD4, TP53, BRCA2, BRCA1, CHEK2, FOXP3

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:00350359.8FOXP3, TP53
2NF-kappaB bindingGO:00510599.8CDKN2A, FOXP3
3MDM2/MDM4 family protein bindingGO:00973719.6TP53, CDKN2A
4ubiquitin protein ligase bindingGO:00316259.1TP53, BRCA1, CHEK2
5identical protein bindingGO:00428029.0NCAM1, CHEK2, TP53, SMAD4
6transcription regulatory region DNA bindingGO:00442129.0BRCA1, TP53, SMAD4
7protein bindingGO:00055155.5CDKN2A, KCNJ3, KCNA4, SMAD4, TP53, SELE

Products for genes affiliated with Pancreas Adenocarcinoma

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Sources for Pancreas Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
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