MCID: PNC033
MIFTS: 46

Pancreas Adenocarcinoma malady

Endocrine diseases category

Summaries for Pancreas Adenocarcinoma

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MalaCards: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to pancreatitis and adenocarcinoma. An important gene associated with Pancreas Adenocarcinoma is AKR7A3 (aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)), and among its related pathways are Gemcitabine Pathway, Pharmacodynamics and DNA damage DNA-damage-induced responses. The compounds thiolutin and heparin sodium salt have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and endothelial, and related mouse phenotypes are normal and hematopoietic system.

Aliases & Classifications for Pancreas Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreas adenocarcinoma 8
pancreatic adenocarcinoma 8 60


External Ids:

Disease Ontology8 DOID:4074
NCIt39 C8294

Related Diseases for Pancreas Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.9SMAD4
2adenocarcinoma30.9SMAD4, KCNJ3, BRCA1, BMP6, NCAM1, CHEK2
3pancreatic cancer30.8BRCA1, BMP6, RRM2, SLC29A1, SMAD4
4insulinoma29.9SMAD4, KCNJ3
5hepatocellular carcinoma29.9FOXP3, BMP6, ERCC1, SMAD4
6prostate cancer29.9BMP6, CHEK2, INHA, ERCC1, SMAD4
7adenoma29.9BRCA1, INHA, ACTC1, ERCC1, SMAD4
8melanoma29.9FOXP3, BMP6, CHEK2, INHA, IL7, ACTC1
9pancreatic ductal adenocarcinoma10.5
10mucinous adenocarcinoma10.2
11peutz-jeghers syndrome10.2
12cholangiocarcinoma10.2
13cystic fibrosis10.1
14alcoholic pancreatitis10.1
15esophagitis10.1
16hepatitis10.1
17prostate adenocarcinoma10.1
18prostatitis10.1
19small cell carcinoma10.0CNN1
20down syndrome10.0INHA
21inflammatory bowel disease10.0FOXP3
22hemangioblastoma10.0INHA
23hepatitis c10.0IL7
24myeloid leukemia10.0BMP6
25endometriosis10.0ACTC1
26myelodysplastic syndromes10.0CHEK2
27infertility10.0INHA
28multiple sclerosis10.0IL7, FOXP3
29fibrosarcoma10.0ACTC1
30leiomyosarcoma10.0ACTC1, INHA
31meningioma10.0INHA, NCAM1
32histiocytosis10.0FSCN3
33sarcoma10.0ACTC1, CHEK2
34cystadenoma10.0INHA, BRCA1
35endometrial stromal sarcoma10.0INHA, ACTC1
36wilms tumor10.0NCAM1, INHA, ACTC1
37cervical cancer10.0IL7, SMAD4
38hypersensitivity reaction type ii disease10.0FOXP3, NCAM1, SELE
39pulmonary fibrosis10.0BMP6
40acute leukemia10.0SLC29A1, IL7, NCAM1
41telangiectasis10.0BMP6, SMAD4
42embryonal rhabdomyosarcoma10.0NCAM1, ACTC1, SMAD4
43bloom syndrome10.0RECQL, BRCA1
44cystic teratoma10.0
45peritonitis10.0
46carcinoid syndrome10.0NCAM1, INHA, ACTC1
47deficiency anemia10.0SMAD4, BRCA1
48leiomyoma10.0SMAD4, ACTC1
49ovarian cystadenoma10.0BRCA1, SELE
50osteosarcoma10.0SMAD4, CHEK2, BMP6

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Clinical Features for Pancreas Adenocarcinoma

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Drugs & Therapeutics for Pancreas Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreas Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Search CenterWatch for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

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Anatomical Context for Pancreas Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Pancreas Adenocarcinoma:

32
Pancreas, Lung, Endothelial, Colon, Liver, Thyroid, T cells, Cervix, Testes, Ovary, Breast, Lymph node

Animal Models for Pancreas Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9BRCA1, FOXP3, INHA, ACTC1, SELE, SMAD4
2MP:00053978.4BRCA1, FOXP3, CHEK2, INHA, IL7, ERCC1
3MP:00053768.0CHEK2, FOXP3, BRCA1, KCNA3, CNN1, INHA
4MP:00053787.8BMP6, FOXP3, BRCA1, KCNA3, NCAM1, INHA
5MP:00053847.8SMAD4, BRCA1, FOXP3, NCAM1, CHEK2, CNN1

Publications for Pancreas Adenocarcinoma

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50PubMed
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Articles related to Pancreas Adenocarcinoma:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Role of radical antegrade modular pancreatosplenectomy for adenocarcinoma of the body and tail of the pancreas. (24166024)
2014
2
Role of endoscopic retrograde pancreatography for early detection of pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas. (22878836)
2013
3
Pulmonary embolism diagnosed with EUS on a patient with adenocarcinoma of the pancreas (with video). (23769142)
2013
4
Reply to an analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment. (23606044)
2013
5
Evolving panorama of treatment for metastatic pancreas adenocarcinoma. (23547071)
2013
6
Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma. (21922151)
2012
7
Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma. (21422912)
2011
8
Impact of selection bias on the utilization of adjuvant therapy for pancreas adenocarcinoma. (19851808)
2010
9
EP300--a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. (19569050)
2010
10
Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. (19692203)
2009
11
Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. (18714398)
2008
12
A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas. (18278438)
2008
13
The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. (18781170)
2008
14
Intestinal type adenocarcinoma: a previously unrecognized histologic variant of ductal carcinoma of the pancreas. (17240300)
2007
15
Prognostic role of angiogenesis and its correlations with thymidine phosphorylase and p53 expression in ductal adenocarcinoma of the pancreas. (18019682)
2007
16
Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature. (17993730)
2007
17
Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon. (16424058)
2006
18
Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. (16416732)
2005
19
A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies. (15953882)
2005
20
Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. (16251039)
2005
21
Aberrant expression of cdx2 homeobox gene in intraductal papillary-mucinous neoplasm of the pancreas but not in pancreatic ductal adenocarcinoma. (15782100)
2005
22
Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. (15662124)
2005
23
Diffuse pancreatic adenocarcinoma identified in an adult with annular pancreas. (15239992)
2004
24
Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas. (14555840)
2004
25
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis. (14669344)
2003
26
Biweekly low-dose sequential gemcitabine, 5-fluorouracil, leucovorin, and cisplatin (GFP): a highly active novel therapy for metastatic adenocarcinoma of the exocrine pancreas. (14533437)
2003
27
Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. (12010891)
2002
28
Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. (12120204)
2001
29
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). (11751476)
2001
30
Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case. (11472568)
2001
31
Immunocytochemical detection of the expression of members of the matrix metalloproteinase family in adenocarcinomas of the pancreas. (11286133)
2001
32
Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas. (9676835)
1998
33
A case of membranous glomerulonephritis associated with adenocarcinoma of pancreas. (9568885)
1998
34
Analysis of p53, p21WAF1, and TGF-beta1 in human ductal adenocarcinoma of the pancreas: TGF-beta1 protein expression predicts longer survival. (9661918)
1998
35
Phase II trial of topotecan in advanced or metastatic adenocarcinoma of the pancreas. (8824355)
1996
36
Differential expression of CD44v6 in adenocarcinoma of the pancreas: an immunohistochemical study. (8972753)
1996
37
Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. (7585621)
1995
38
Estrogen receptor detection in paraffin sections of adenocarcinoma of the colon, pancreas, and lung. (8204009)
1994
39
Cytogenetic characterization of a periampullary adenocarcinoma of the pancreas, its liver metastasis, and a cell line established from the metastasis and a cell line established from the metastasis in a patient with Gardner's syndrome. (8076346)
1994
40
Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. (7804431)
1994
41
Overexpression of p53 protein in adenocarcinoma of the pancreas. (8209852)
1994
42
Multifocal intraductal papillary adenocarcinoma of the pancreas: report of a case. (8391885)
1993
43
Treatment of adenocarcinoma of the pancreas with somatostatin and gonadoliberin (luteinizing hormone-releasing hormone). The French Associations for Surgical Research. (1357998)
1992
44
Adenocarcinoma and concomitant intraductal papillary adenoma in the pancreas. (1805050)
1991
45
Mucinous adenocarcinoma of the pancreas. (1646978)
1991
46
An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas. (2403740)
1990
47
Diffuse intraductal papillary adenocarcinoma of the pancreas. (3827359)
1987
48
Scirrhous adenocarcinoma arising in a lipomatous pseudohypertrophic pancreas. (14441042)
1960
49
Studies on human cancer using sponge matrix tissue culture. I. The growth patterns of a malignant melanoma, adenocarcinoma of the parotid gland, papillary adenocarcinoma of the thyroid gland, adenocarcinoma of the pancreas, and epidermoid carcinoma of the uterine cervix (Gey's HeLa strain). (13238257)
1954
50
Papillary adenocarcinoma of head of pancreas, with metastases to common bile duct and lung. (21008846)
1946

Genetic Variations for Pancreas Adenocarcinoma

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Expression for genes affiliated with Pancreas Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreas Adenocarcinoma

Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

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49PharmGKB, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Pathways related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9RRM2, SLC29A1
29.9CHEK2, BRCA1
3
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9.5RRM2, CHEK2, BRCA1
4
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9.4KCNA3, KCNA4, KCNJ3
5
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9.3ERCC1, RECQL, CHEK2, BRCA1

Compounds for genes affiliated with Pancreas Adenocarcinoma

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59Tocris Bioscience, 44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1thiolutin5910.4NCAM1, SELE
2heparin sodium salt5910.4NCAM1, SELE
3echistatin, alpha1 isoform5910.4NCAM1, SELE
4rgds peptide5910.4NCAM1, SELE
5ac2-265910.3NCAM1, SELE
6deoxycytidine44 2411.1RRM2, SLC29A1, ERCC1
7hematoxylin4410.1ACTC1, INHA, NCAM1
8okt34410.0SELE, IL7, BMP6
9cyclophosphamide44 49 1112.0SELE, ERCC1, IL7, BRCA1
102-methoxyethanol449.9ACTC1, BMP6
115fluorouracil449.9BRCA1, SLC29A1, ERCC1, SELE
12thymidylate449.9BRCA1, RRM2, SLC29A1, ERCC1
13lactacystin449.8SELE, ERCC1, BRCA1
14reticulin449.8ACTC1, BMP6
15losartan44 49 28 1112.8SMAD4, SELE, BMP6
16etoposide44 49 59 1112.8BRCA1, CHEK2, ERCC1, SELE
17vincristine44 49 1111.7ERCC1, NCAM1, BMP6, BRCA1
18hydroxyurea44 49 1111.7BRCA1, CHEK2, RRM2
19methotrexate44 49 1111.7BRCA1, BMP6, ERCC1, SELE
20paraffin449.7BRCA1, NCAM1, INHA, ACTC1, SMAD4
21creatinine449.7BMP6, NCAM1, ACTC1, SELE
22matrigel449.6SELE, ACTC1, NCAM1, BMP6
23gemcitabine44 49 1111.6BRCA1, CHEK2, RRM2, SLC29A1, ERCC1
24rapamycin449.6FOXP3, BMP6, CHEK2, IL7, ERCC1
25agar449.6BRCA1, BMP6, IL7, SMAD4
26histamine44 28 2411.4BMP6, NCAM1, IL7, SELE
27dopamine44 28 11 2412.4NCAM1, BMP6, KCNA4, KCNJ3
28heparin44 28 11 2412.3BRCA1, BMP6, NCAM1, IL7, SELE
29progesterone44 59 28 11 2413.3BRCA1, BMP6, NCAM1, INHA, IL7, ACTC1
30testosterone44 59 11 2412.3BRCA1, NCAM1, INHA, IL7, ACTC1, SELE
31cisplatin44 49 59 1112.3BRCA1, BMP6, CHEK2, RRM2, ERCC1
32phosphatidylinositol449.2BRCA1, BMP6, NCAM1, CHEK2, IL7, ERCC1
33nitric oxide44 11 2411.1FOXP3, BMP6, NCAM1, IL7, SLC29A1, SELE
34oligonucleotide449.0BRCA1, BMP6, CHEK2, INHA, IL7, ERCC1
35steroid449.0BRCA1, INHA, IL7, ACTC1, SMAD4
36retinoic acid44 2410.0BRCA1, BMP6, NCAM1, CHEK2, IL7, ACTC1
37thymidine44 2410.0BRCA1, BMP6, IL7, RRM2, SLC29A1, ERCC1
38atp44 289.9BRCA1, NCAM1, CHEK2, RECQL, IL7, RRM2
39vegf448.9BRCA1, BMP6, NCAM1, IL7, ACTC1, ERCC1
40alanine448.8BRCA1, BMP6, NCAM1, CHEK2, INHA, IL7
41doxorubicin44 49 1110.7SELE, BRCA1, BMP6, NCAM1, CHEK2, IL7
42serine448.4BRCA1, BMP6, NCAM1, CHEK2, IL7, SELE
43tyrosine448.2BRCA1, BMP6, NCAM1, CHEK2, INHA, IL7

GO Terms for genes affiliated with Pancreas Adenocarcinoma

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16Gene Ontology
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Cellular components related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.4KCNA3, KCNA4, KCNJ3

Biological processes related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interferon-gamma biosynthetic processGO:04507710.2INHA, FOXP3
2actomyosin structure organizationGO:0310329.9ACTC1, CNN1
3double-strand break repairGO:0063029.8ERCC1, CHEK2, BRCA1
4SMAD protein signal transductionGO:0603959.8SMAD4, BMP6
5positive regulation of histone acetylationGO:0350669.7FOXP3, BRCA1
6potassium ion transportGO:0068139.4KCNJ3, KCNA4, KCNA3

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1SMAD4, KCNA4, BRCA1, FOXP3, CHEK2, RECQL

Products for genes affiliated with Pancreas Adenocarcinoma

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Sources for Pancreas Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet