MCID: PNC033
MIFTS: 46

Pancreas Adenocarcinoma malady

Endocrine diseases category

Summaries for Pancreas Adenocarcinoma

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MalaCards: Pancreas Adenocarcinoma, also known as pancreatic adenocarcinoma, is related to pancreatitis and adenocarcinoma. An important gene associated with Pancreas Adenocarcinoma is AKR7A3 (aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)), and among its related pathways are Gemcitabine Pathway, Pharmacodynamics and DNA damage DNA-damage-induced responses. The compounds thiolutin and heparin sodium salt have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related mouse phenotypes are normal and hematopoietic system.

Aliases & Classifications for Pancreas Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreas adenocarcinoma 8
pancreatic adenocarcinoma 8 60


External Ids:

Disease Ontology8 DOID:4074
NCIt39 C8294

Related Diseases for Pancreas Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Pancreas Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.9SMAD4
2adenocarcinoma30.9SMAD4, KCNJ3, BRCA1, BMP6, NCAM1, CHEK2
3pancreatic cancer30.8BRCA1, BMP6, RRM2, SLC29A1, SMAD4
4insulinoma29.9SMAD4, KCNJ3
5hepatocellular carcinoma29.9FOXP3, BMP6, ERCC1, SMAD4
6prostate cancer29.9BMP6, CHEK2, INHA, ERCC1, SMAD4
7adenoma29.9BRCA1, INHA, ACTC1, ERCC1, SMAD4
8melanoma29.9FOXP3, BMP6, CHEK2, INHA, IL7, ACTC1
9pancreatic ductal adenocarcinoma10.5
10mucinous adenocarcinoma10.2
11peutz-jeghers syndrome10.2
12cholangiocarcinoma10.2
13cystic fibrosis10.1
14alcoholic pancreatitis10.1
15esophagitis10.1
16hepatitis10.1
17prostate adenocarcinoma10.1
18prostatitis10.1
19small cell carcinoma10.0CNN1
20down syndrome10.0INHA
21inflammatory bowel disease10.0FOXP3
22hemangioblastoma10.0INHA
23hepatitis c10.0IL7
24myeloid leukemia10.0BMP6
25endometriosis10.0ACTC1
26myelodysplastic syndromes10.0CHEK2
27infertility10.0INHA
28multiple sclerosis10.0IL7, FOXP3
29fibrosarcoma10.0ACTC1
30leiomyosarcoma10.0ACTC1, INHA
31meningioma10.0INHA, NCAM1
32histiocytosis10.0FSCN3
33sarcoma10.0ACTC1, CHEK2
34cystadenoma10.0INHA, BRCA1
35endometrial stromal sarcoma10.0INHA, ACTC1
36wilms tumor10.0NCAM1, INHA, ACTC1
37cervical cancer10.0IL7, SMAD4
38hypersensitivity reaction type ii disease10.0FOXP3, NCAM1, SELE
39pulmonary fibrosis10.0BMP6
40acute leukemia10.0SLC29A1, IL7, NCAM1
41telangiectasis10.0BMP6, SMAD4
42embryonal rhabdomyosarcoma10.0NCAM1, ACTC1, SMAD4
43bloom syndrome10.0RECQL, BRCA1
44cystic teratoma10.0
45peritonitis10.0
46carcinoid syndrome10.0NCAM1, INHA, ACTC1
47deficiency anemia10.0SMAD4, BRCA1
48leiomyoma10.0SMAD4, ACTC1
49ovarian cystadenoma10.0BRCA1, SELE
50osteosarcoma10.0SMAD4, CHEK2, BMP6

Graphical network of the top 20 diseases related to Pancreas Adenocarcinoma:



Diseases related to pancreas adenocarcinoma

Clinical Features for Pancreas Adenocarcinoma

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Drugs & Therapeutics for Pancreas Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreas Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Pancreas Adenocarcinoma

Search NIH Clinical Center for Pancreas Adenocarcinoma

Search CenterWatch for Pancreas Adenocarcinoma

Genetic Tests for Pancreas Adenocarcinoma

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Anatomical Context for Pancreas Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Pancreas Adenocarcinoma:

32
Pancreas, Lung, Liver, Colon, Endothelial, Thyroid, T cells, Testes, Breast, Lymph node, Ovary, Cervix

Animal Models for Pancreas Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreas Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9BRCA1, FOXP3, INHA, ACTC1, SELE, SMAD4
2MP:00053978.4BRCA1, SMAD4, SELE, ERCC1, IL7, INHA
3MP:00053768.0SMAD4, ERCC1, ACTC1, INHA, CNN1, CHEK2
4MP:00053787.8SMAD4, KCNA3, SELE, ERCC1, ACTC1, SLC29A1
5MP:00053847.8RECQL, SELE, ERCC1, ACTC1, IL7, SMAD4

Publications for Pancreas Adenocarcinoma

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50PubMed
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Articles related to Pancreas Adenocarcinoma:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Extracapsular lymph node spread as a negative prognostic factor of adenocarcinoma of the pancreas and cancer of the papilla of vater. (24212239)
2014
2
Optimal Duration and Timing of Adjuvant Chemotherapy After Definitive Surgery for Ductal Adenocarcinoma of the Pancreas: Ongoing Lessons From the ESPAC-3 Study. (24419109)
2014
3
Should extended lymphadenectomy be performed for adenocarcinoma of the head of the pancreas? A meta-analysis and systematic review. (24164704)
2013
4
Adjuvant therapy for pancreas adenocarcinoma. (22886586)
2013
5
Sarcoidosis of the pancreas mimicking adenocarcinoma. (23784760)
2013
6
Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy. (24183345)
2013
7
Preoperative CEA and CA 19-9 are prognostic markers for survival after curative resection for ductal adenocarcinoma of the pancreas - a retrospective tumor marker prognostic study. (24161419)
2013
8
A prognostic model to identify patients with advanced pancreas adenocarcinoma who could benefit from second-line chemotherapy. (21382702)
2012
9
The association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreas. (22812722)
2012
10
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon. (22542127)
2012
11
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
12
Pancreas-protocol imaging at a high-volume center leads to improved preoperative staging of pancreatic ductal adenocarcinoma. (21484522)
2011
13
The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature. (21512846)
2011
14
Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. (20233622)
2010
15
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. (19270646)
2009
16
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. (19274673)
2009
17
Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions. (19821078)
2009
18
Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas. (19128923)
2009
19
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. (19465885)
2009
20
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas. (18261235)
2008
21
Survival and prognosis of invasive intraductal papillary mucinous neoplasms of the pancreas: comparison with pancreatic ductal adenocarcinoma. (18192881)
2008
22
672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. (18656619)
2008
23
Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. (18836784)
2008
24
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. (17349581)
2007
25
Pancreatic intraepithelial neoplasia in heterotopic pancreas: evidence for the progression model of pancreatic ductal adenocarcinoma. (17667542)
2007
26
Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. (17909725)
2007
27
Osteopontin expression in ductal adenocarcinomas and undifferentiated carcinomas of the pancreas. (15568158)
2005
28
Expression and prognostic roles of integrins and interleukin-1 receptor type I in patients with ductal adenocarcinoma of the pancreas. (12870779)
2003
29
Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma. (12894360)
2003
30
Apoptosis and expression of bcl-2 protein in invasive ductal adenocarcinoma of the pancreas]. (14663927)
2003
31
Immunohistochemical study of endocrine cells in ductal adenocarcinoma of the pancreas. (12242521)
2002
32
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. (11943721)
2002
33
Nonmucin-producing intraductal papillary adenocarcinoma of the pancreas in a young woman. (11677487)
2001
34
The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. (11420467)
2001
35
Reduced expression of p53 and cyclin A in intraductal mucin-hypersecreting neoplasm of the pancreas compared with usual pancreatic ductal adenocarcinoma. (10445560)
1999
36
Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas. (10546833)
1999
37
Interleukin 1beta-converting enzyme (caspase-1) is overexpressed in adenocarcinoma of the pancreas. (9661876)
1998
38
Histochemical determination of stereoselectivity of esterases in normal pancreas and pancreatic tubular adenocarcinoma of hamsters. (9554581)
1998
39
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. (9448015)
1998
40
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. (9459160)
1998
41
Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. (9239407)
1997
42
Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: histochemical and immunohistochemical study with review of the literature. (9260206)
1997
43
Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas. (9166939)
1997
44
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen. (8797870)
1996
45
Intraductal papillary adenocarcinoma with mucin hypersecretion and coexistent invasive ductal carcinoma of the pancreas with apparent topographic separation. (9027658)
1996
46
Intraductal mucin-hypersecreting papillary adenocarcinoma of the pancreas: a case report. (7850686)
1994
47
Signet-ring mucinous adenocarcinoma of the pancreas. (7865839)
1994
48
The prognostic value of the tumour markers CA 195 and CEA in patients with adenocarcinoma of the pancreas. (1426303)
1992
49
Coexistent adenocarcinoma and microcystic adenoma of the pancreas. (1933654)
1991
50
WEEKLY clinicopathological exercise: scirrhous adenocarcinoma of pancreas with metastases to the liver. (14910848)
1952

Genetic Variations for Pancreas Adenocarcinoma

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Expression for genes affiliated with Pancreas Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreas Adenocarcinoma

Search GEO for disease gene expression data for Pancreas Adenocarcinoma.

Pathways for genes affiliated with Pancreas Adenocarcinoma

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49PharmGKB, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Pathways related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SLC29A1, RRM2
29.9CHEK2, BRCA1
3
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9.5BRCA1, CHEK2, RRM2
4
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9.4KCNA3, KCNA4, KCNJ3
5
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9.3ERCC1, RECQL, CHEK2, BRCA1

Compounds for genes affiliated with Pancreas Adenocarcinoma

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59Tocris Bioscience, 44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1thiolutin5910.4NCAM1, SELE
2heparin sodium salt5910.4NCAM1, SELE
3echistatin, alpha1 isoform5910.4NCAM1, SELE
4rgds peptide5910.4NCAM1, SELE
5ac2-265910.3NCAM1, SELE
6deoxycytidine44 2411.1RRM2, SLC29A1, ERCC1
7hematoxylin4410.1ACTC1, INHA, NCAM1
8okt34410.0SELE, IL7, BMP6
9cyclophosphamide44 49 1112.0SELE, ERCC1, IL7, BRCA1
102-methoxyethanol449.9ACTC1, BMP6
115fluorouracil449.9BRCA1, SLC29A1, ERCC1, SELE
12thymidylate449.9BRCA1, RRM2, SLC29A1, ERCC1
13lactacystin449.8SELE, ERCC1, BRCA1
14reticulin449.8ACTC1, BMP6
15losartan44 49 28 1112.8SMAD4, SELE, BMP6
16etoposide44 49 59 1112.8BRCA1, CHEK2, ERCC1, SELE
17vincristine44 49 1111.7ERCC1, NCAM1, BMP6, BRCA1
18hydroxyurea44 49 1111.7BRCA1, CHEK2, RRM2
19methotrexate44 49 1111.7BRCA1, BMP6, ERCC1, SELE
20paraffin449.7BRCA1, NCAM1, INHA, ACTC1, SMAD4
21creatinine449.7BMP6, NCAM1, ACTC1, SELE
22matrigel449.6SELE, ACTC1, NCAM1, BMP6
23gemcitabine44 49 1111.6BRCA1, CHEK2, RRM2, SLC29A1, ERCC1
24rapamycin449.6FOXP3, BMP6, CHEK2, IL7, ERCC1
25agar449.6BRCA1, BMP6, IL7, SMAD4
26histamine44 28 2411.4BMP6, NCAM1, IL7, SELE
27dopamine44 28 11 2412.4NCAM1, BMP6, KCNA4, KCNJ3
28heparin44 28 11 2412.3BRCA1, BMP6, NCAM1, IL7, SELE
29progesterone44 59 28 11 2413.3BRCA1, BMP6, NCAM1, INHA, IL7, ACTC1
30testosterone44 59 11 2412.3BRCA1, NCAM1, INHA, IL7, ACTC1, SELE
31cisplatin44 49 59 1112.3BRCA1, BMP6, CHEK2, RRM2, ERCC1
32phosphatidylinositol449.2BRCA1, BMP6, NCAM1, CHEK2, IL7, ERCC1
33nitric oxide44 11 2411.1FOXP3, BMP6, NCAM1, IL7, SLC29A1, SELE
34oligonucleotide449.0BRCA1, BMP6, CHEK2, INHA, IL7, ERCC1
35steroid449.0BRCA1, INHA, IL7, ACTC1, SMAD4
36retinoic acid44 2410.0BRCA1, BMP6, NCAM1, CHEK2, IL7, ACTC1
37thymidine44 2410.0BRCA1, BMP6, IL7, RRM2, SLC29A1, ERCC1
38atp44 289.9BRCA1, NCAM1, CHEK2, RECQL, IL7, RRM2
39vegf448.9BRCA1, BMP6, NCAM1, IL7, ACTC1, ERCC1
40alanine448.8BRCA1, BMP6, NCAM1, CHEK2, INHA, IL7
41doxorubicin44 49 1110.7SELE, BRCA1, BMP6, NCAM1, CHEK2, IL7
42serine448.4BRCA1, BMP6, NCAM1, CHEK2, IL7, SELE
43tyrosine448.2BRCA1, BMP6, NCAM1, CHEK2, INHA, IL7

GO Terms for genes affiliated with Pancreas Adenocarcinoma

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16Gene Ontology
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Cellular components related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.4KCNA3, KCNA4, KCNJ3

Biological processes related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interferon-gamma biosynthetic processGO:04507710.2FOXP3, INHA
2positive regulation of histone acetylationGO:0350669.9BRCA1, FOXP3
3double-strand break repairGO:0063029.8ERCC1, CHEK2, BRCA1
4SMAD protein signal transductionGO:0603959.8SMAD4, BMP6
5actomyosin structure organizationGO:0310329.7CNN1, ACTC1
6potassium ion transportGO:0068139.4KCNA3, KCNA4, KCNJ3

Molecular functions related to Pancreas Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1SMAD4, KCNA4, BRCA1, FOXP3, CHEK2, RECQL

Products for genes affiliated with Pancreas Adenocarcinoma

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Sources for Pancreas Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet