MCID: PNC035
MIFTS: 95

Pancreatic Cancer malady

Cancer diseases, Gastrointestinal diseases, Endocrine diseases, Genetic diseases categories

Summaries for Pancreatic Cancer

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The pancreas is a gland behind your stomach and in front of your spine. it produces the juices that help break down food and the hormones that help control blood sugar levels. pancreatic cancer usually begins in the cells that produce the juices. some risk factors for developing pancreatic cancer include smoking long-term diabetes chronic pancreatitis certain hereditary disorders pancreatic cancer is hard to catch early. it doesn't cause symptoms right away. when you do get symptoms, they are often vague or you may not notice them. they include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it. because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. possible treatments include surgery, radiation, chemotherapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Pancreatic Cancer, also known as pancreatic carcinoma, is related to pancreatitis and nasopharynx carcinoma. An important gene associated with Pancreatic Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Pathways in cancer and Apoptotic Pathways in Synovial Fibroblasts. The drugs octreotide and octreotide acetate and the compounds vegf and paraffin have been mentioned in the context of this disorder. Affiliated tissues include the pancreas, pancreas and endothelial, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An endocrine gland cancer located in the pancreas.

NIH Rare Diseases:42 Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. the pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. possible treatments include surgery, radiation, and chemotherapy. last updated: 9/17/2013

Wikipedia:63 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

Description from OMIM:46 260350,606856,613347,613348,614320

Aliases & Classifications for Pancreatic Cancer

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 22GTR, 39NCIt, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
pancreatic cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood
familial pancreatic carcinoma:
Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

pancreatic cancer 8 9 42 46 10 44 48 33
pancreatic carcinoma 8 44 48 60
pancreatic neoplasm 8 60
pancreatic tumor 8 44
cancer pancreas 42 22
malignant neoplasm of tail of pancreas 8
malignant neoplasm of body of pancreas 8
malignant neoplasm of head of pancreas 8
malignant tumor of tail of pancreas 8
malignant tumor of body of pancreas 8
malignant neoplasm of pancreas 60
pancreatic carcinoma, familial 60
familial pancreatic carcinoma 48
exocrine pancreas carcinoma 8
familial pancreatic cancer 48
cancer of the pancreas 42
carcinoma of pancreas 8
neoplasm of pancreas 8
ca tail of pancreas 8
ca head of pancreas 8
malignant neoplasms 60
ca body of pancreas 8
pancreas neoplasm 8


External Ids:

Disease Ontology8 DOID:1793, DOID:4905
NCIt39 C3305, C3850
ICD10 via Orphanet26 C25
SNOMED-CT via Orphanet57 372142002
UMLS via Orphanet61 C0235974, C2931038
MESH via Orphanet35 D010190, C535837

Related Diseases for Pancreatic Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pancreatic Cancer family:

Pancreatic Carcinoma, Familial Pancreatic Cancer 1
Pancreatic Cancer 3 Pancreatic Cancer 4

Diseases related to Pancreatic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 842)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.5BRCA2, KRAS, SMAD4
2nasopharynx carcinoma30.9CDKN2A, TP53
3colorectal cancer30.8BRCA1, BRCA2, TNFRSF10B, PPARG, STK11, EGFR
4breast cancer30.8BRCA1, BRCA2
5adenocarcinoma30.8EGFR, STK11, SCTR, TNFRSF10B, BRCA2, BRCA1
6melanoma30.7BRCA2, TP53, KRAS, PLAU, MMP2, CDKN2A
7colon cancer30.7TNFRSF10B, EGFR, MMP2, PLAU, KRAS, SMAD4
8oral cavity cancer30.7TP53
9hepatitis30.5KRAS
10prostate cancer30.5SMAD4, PLAU, MMP2, EGFR
11lung cancer30.5PPARG, STK11, EGFR, AKT2, MMP2, PLAU
12acute leukemia30.4KRAS
13gallbladder cancer30.4TP53, KRAS
14peutz-jeghers syndrome30.4STK11, BRCA2
15diabetes mellitus30.4PPARG, AKT2
16osteosarcoma30.4TP53, SMAD4, PLAU, MMP2, CDKN2A, GLI1
17ovarian cancer30.4BRCA1, BRCA2, TNFRSF10B, EGFR, AKT2, CDKN2A
18fallopian tube cancer30.4BRCA1, BRCA2
19breast-ovarian cancer, familial, 230.3BRCA2
20hepatitis b30.3KRAS
21retinoblastoma30.2BRCA1, BRCA2, PPARG, EGFR, CDKN2A, KRAS
22transitional cell carcinoma30.2EGFR, PLAU, TP53
23endometrial carcinoma30.1CDKN2A, KRAS, TP53
24oropharyngeal cancer, adult30.1CDKN2A, TP53
25adenoma30.1BRCA1, TNFRSF10B, PPARG, STK11, CDKN2A, KRAS
26stomach cancer30.1TP53
27brain cancer30.0EGFR, GLI1, PLAU, TP53
28cholangiocarcinoma30.0KRAS, SMAD4, TP53
29esophageal cancer30.0CDKN2A, SMAD4, TP53
30lynch syndrome30.0BRCA1, BRCA2
31obesity30.0PPARG
32burkitt's lymphoma30.0KLF10, BRCA2, TNFRSF10B, CDKN2A, KRAS, SMAD4
33papillary carcinoma30.0SMAD4, PPARG, BRCA2
34cystadenoma30.0BRCA1, KRAS
35multiple myeloma30.0TP53, CDKN2A
36leiomyosarcoma30.0TP53
37thymoma30.0AKT2
38cervical adenocarcinoma30.0CDKN2A
39li-fraumeni syndrome29.9CDKN2A, TP53
40familial adenomatous polyposis29.9BRCA1, TNFRSF10B, PPARG, STK11, KRAS, SMAD4
41malignant mesothelioma29.9CDKN2A, TNFRSF10B
42gastrinoma29.9SMAD4, SCTR
43hepatocellular carcinoma29.9BRCA2, TNFRSF10B, STK11, CDKN2A, MMP2, PLAU
44non-small cell lung carcinoma29.8PPARG, STK11, EGFR, CDKN2A, KRAS, TP53
45lung small cell carcinoma29.8EGFR, CDKN2A, KRAS, TP53
46bladder carcinoma29.8TP53, CDKN2A
47leukemia29.8BRCA1, BRCA2, TNFRSF10B, CDKN2A, KRAS, TP53
48cervical cancer29.8STK11, EGFR, CDKN2A, MMP2, SMAD4, TP53
49kidney cancer29.8EGFR, TP53
50thyroid cancer29.8TP53, PPARG

Graphical network of the top 20 diseases related to Pancreatic Cancer:



Diseases related to pancreatic cancer

Clinical Features for Pancreatic Cancer

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46OMIM
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Clinical features from OMIM:

260350,606856,613347,613348,614320

Drugs & Therapeutics for Pancreatic Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pancreatic Cancer

Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer

Search NIH Clinical Center for Pancreatic Cancer

Search CenterWatch for Pancreatic Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pancreatic Cancer

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22GTR
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Genetic tests related to Pancreatic Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Pancreas22

Anatomical Context for Pancreatic Cancer

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pancreatic Cancer:

32
Pancreas, Endothelial, Skin, Eye, Liver, Breast, Testes, Colon, Lymph node, T cells, Lung, Bone, Prostate, Myeloid, Monocytes, Testis, Pituitary, Thyroid, Brain, Bone marrow, Kidney, Pancreatic islet, Fetal liver, Spleen, Nk cells, Skeletal muscle

FMA organs/tissues related to Pancreatic Cancer:

14
The pancreas

Animal Models for Pancreatic Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatic Cancer:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538414.1EGFR, STK11, PPARG, TNFRSF10B, BRCA2, BRCA1
2MP:001076814.1AKT2, EGFR, STK11, PPARG, TNFRSF10B, BRCA2
3MP:000538713.7BRCA1, BRCA2, TNFRSF10B, SCTR, PPARG, STK11
4MP:000537813.6AKT2, EGFR, STK11, PPARG, BRCA2, BRCA1
5MP:000539713.5BRCA1, BRCA2, TNFRSF10B, SCTR, PPARG, STK11
6MP:000538913.0BRCA1, BRCA2, STK11, EGFR, AKT2, GLI1
7MP:000287313.0STK11, PPARG, BRCA2, BRCA1, EGFR, AKT2
8MP:000200612.9SMAD4, KLF10, TNFRSF10B, PPARG, STK11, EGFR
9MP:000538112.8BRCA1, BRCA2, STK11, EGFR, GLI1, CDKN2A
10MP:001077112.7KLF10, BRCA1, BRCA2, STK11, CDKN2A, KRAS
11MP:000538512.6BRCA1, PPARG, STK11, EGFR, MMP2, PLAU
12MP:000537012.5PPARG, STK11, EGFR, AKT2, CDKN2A, PLAU
13MP:000538812.4BRCA1, EGFR, AKT2, GLI1, MMP2, PLAU
14MP:000538612.2BRCA1, BRCA2, SCTR, PPARG, STK11, GLI1
15MP:000301212.1TNFRSF10B, PPARG, STK11, EGFR, AKT2, GLI1
16MP:000536712.1BRCA1, SCTR, PPARG, STK11, EGFR, GLI1
17MP:000537612.0KLF10, BRCA1, BRCA2, TNFRSF10B, SCTR, AKT2
18MP:000536912.0AKT2, CDKN2A, MMP2, PLAU, SMAD4, TP53
19MP:000537911.9BRCA1, BRCA2, CDKN2A, KRAS, TP53
20MP:000538011.8PPARG, GLI1, PALB2, PALLD, SMAD4
21MP:000539011.8KLF10, BRCA1, BRCA2, FAM3C, AKT2
22MP:000363111.7PPARG, GLI1, PALB2, PALLD
23MP:000537111.2BRCA2, GLI1, PALB2
24MP:000539111.2PPARG, STK11, EGFR, PLAU
25MP:000537510.9PLAU, AKT2

Publications for Pancreatic Cancer

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50PubMed
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Articles related to Pancreatic Cancer:

(show top 50)    (show all 3510)
idTitleAuthorsYear
1
Translational Research in Pancreatic Cancer: KRAS and Beyond. (24326376)
2014
2
Surface plasmon resonance-induced photoactivation of gold nanoparticles as mitochondria-targeted therapeutic agents for pancreatic cancer. (24188208)
2013
3
The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits. (24073725)
2013
4
Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer. (24075798)
2013
5
Advances of high intensity focused ultrasound (HIFU) for pancreatic cancer. (24102396)
2013
6
Combined radiochemotherapy in patients with locally advanced pancreatic cancer: a meta-analysis. (24259979)
2013
7
Comparison of prognosis between patients of pancreatic head cancer with andA without obstructive jaundice at diagnosis. (23467105)
2013
8
Usefulness of 18F-fluorodeoxyglucose Positron Emission Tomography as Predictor of Distant Metastasis in Preoperative Carbon-ion Radiotherapy for Pancreatic Cancer. (24324101)
2013
9
Risk Factors and Therapeutic Targets in Pancreatic Cancer. (24303367)
2013
10
The effect of simvastatin on lipid droplets accumulation in human embryonic kidney cells and pancreatic cancer cells. (23961716)
2013
11
MTHFR polymorphisms and pancreatic cancer risk: lack of evidence from a meta-analysis. (22901202)
2012
12
High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. (22384823)
2012
13
A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer. (22277584)
2012
14
Mutant K-Ras increases GSK-3I^ gene expression via an ETS-p300 transcriptional complex in pancreatic cancer. (21441955)
2011
15
Evidence that serum levels of the soluble receptor for advanced glycation end products are inversely associated with pancreatic cancer risk: a prospective study. (21540233)
2011
16
Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. (19747919)
2009
17
14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness. (19047086)
2008
18
Early bile duct cancer in a background of sclerosing cholangitis and autoimmune pancreatitis. (19043254)
2008
19
Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer. (17973266)
2007
20
Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells. (17312464)
2007
21
Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis. (17632316)
2007
22
Imatinib mesylate for targeting the platelet-derived growth factor beta receptor in combination with fluorouracil and leucovorin in patients with refractory pancreatic, bile duct, colorectal, or gastric cancer--a dose-escalation Phase I trial. (17377918)
2007
23
Interferon receptor alpha/beta is associated with improved survival after adjuvant therapy in resected pancreatic cancer. (18345307)
2007
24
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. (17409437)
2007
25
Troxacitabine prodrugs for pancreatic cancer. (18058539)
2007
26
The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations. (18049799)
2006
27
Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. (15705899)
2005
28
Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. (14604996)
2004
29
Epidemiology and prevention of pancreatic cancer. (15231857)
2004
30
Can IL-2R alpha be a valuable marker along with CA 19-9 in the diagnosis of chronic pancreatitis and pancreatic cancer? (15503821)
2004
31
Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway. (15451430)
2004
32
Detection of multidrug resistant gene 1 in pancreatic cancer. (15138133)
2004
33
Antiangiogenic effect of somatostatin receptor subtype 2 on pancreatic cancer cell line: Inhibition of vascular endothelial growth factor and matrix metalloproteinase-2 expression in vitro. (14760765)
2004
34
Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. (12883267)
2003
35
Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. (14581375)
2003
36
Surveillance for familial pancreatic cancer. (14743890)
2003
37
N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. (12649567)
2003
38
Correspondence re: Weinberg et al., Cholecystokinin and gastrin levels are not elevated in pancreatic carcinoma. Cancer Epidemiol. Biomark. Prev., 10: 721-722, 2001. (11867513)
2002
39
Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer. (14612290)
2002
40
p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. (11585747)
2001
41
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). (11751476)
2001
42
Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. (11406559)
2001
43
Transforming growth factor alpha (TGF-alpha) increases cell number in a human pancreatic cancer cell line but not in normal mouse pancreas. (11373057)
2000
44
The growth inhibitory effects by transfection of p16 gene on human pancreatic cancer cell line]. (11832084)
2000
45
Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. (10561305)
1999
46
Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells. (9624529)
1998
47
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. (9766646)
1998
48
The molecular and cellular biology of pancreatic cancer. (9807701)
1998
49
Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. (8430098)
1993
50
Correlation of proliferation of pancreatic cancer cells with both saturation index and cell membrane insulin receptors]. (1363899)
1992

Genetic Variations for Pancreatic Cancer

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Expression for genes affiliated with Pancreatic Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Cancer

Search GEO for disease gene expression data for Pancreatic Cancer.

Pathways for genes affiliated with Pancreatic Cancer

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Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 52R&D Systems, 55SinoBiological, 53Reactome, 59Tocris Bioscience
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Pathways related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.5TP53, BRCA2, PPARG, EGFR, AKT2, GLI1
2
Hide members
12.1TNFRSF10B, PPARG, EGFR, AKT2, CDKN2A, MMP2
311.9BRCA1, BRCA2, STK11, EGFR, KRAS, SMAD4
411.9BRCA1, BRCA2, STK11, EGFR, KRAS, SMAD4
5
Hide members
11.9BRCA2, EGFR, AKT2, CDKN2A, KRAS, SMAD4
6
Hide members
11.9BRCA1, TNFRSF10B, STK11, EGFR, AKT2, CDKN2A
711.7BRCA1, STK11, EGFR, AKT2, KRAS, TP53
811.7BRCA1, EGFR, CDKN2A, PLAU, KRAS, TP53
911.7EGFR, AKT2, MMP2, PLAU, KRAS, TP53
10
Hide members
11.5BRCA1, BRCA2, AKT2, KRAS, TP53
11
Hide members
11.5EGFR, AKT2, KRAS, SMAD4, TP53
12
Hide members
11.5BRCA1, BRCA2, AKT2, MMP2, TP53
13
Hide members
11.5AKT2, CDKN2A, PLAU, SMAD4, TP53
14
Translation Insulin regulation of translation
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11.5STK11, EGFR, AKT2, PLAU, KRAS
15
Hide members
11.5EGFR, AKT2, PLAU, KRAS, TP53
16
Hide members
11.3TP53, SMAD4, KRAS, AKT2
1711.3TP53, SMAD4, PLAU, CDKN2A
18
Cell cycle Cell cycle (generic schema)
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11.3BRCA1, AKT2, CDKN2A, SMAD4
19
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11.3EGFR, AKT2, KRAS, TP53
20
Hide members
11.3TP53, KRAS, AKT2, EGFR
2111.3EGFR, AKT2, KRAS, TP53
2211.3EGFR, AKT2, KRAS, TP53
2311.3EGFR, AKT2, CDKN2A, TP53
2411.3PPARG, AKT2, KRAS, SMAD4
25
Hide members
11.3TP53, CDKN2A, TNFRSF10B, BRCA1
26
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11.3BRCA1, AKT2, PLAU, KRAS
27
Development Endothelin-1/EDNRA signaling
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11.3EGFR, AKT2, MMP2, KRAS
2811.3TNFRSF10B, EGFR, MMP2, TP53
2911.1TP53, SMAD4, STK11
3011.1TP53, BRCA2, BRCA1
31
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
11.1TP53, BRCA2, BRCA1
3211.1CDKN2A, KRAS, TP53
3311.1BRCA1, SMAD4, TP53
3411.1STK11, AKT2, TP53
3511.1PALB2, BRCA2, BRCA1
36
Transcription P53 signaling pathway
Hide members
11.1CDKN2A, MMP2, TP53
3711.1PPARG, KRAS, TP53
38
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1TP53, KRAS, PPARG
3911.1SMAD4, EGFR, BRCA1
4011.1TP53, AKT2, EGFR
41
Transcription Androgen Receptor nuclear signaling
Hide members
11.1EGFR, AKT2, MMP2
4211.1BRCA1, MMP2, PLAU
43
Cell adhesion ECM remodeling
Hide members
11.1EGFR, MMP2, PLAU
4410.9TP53, PALB2
4510.9BRCA1, TP53
46
Hide members
10.9AKT2, KRAS
47
Hide members
10.9AKT2, PPARG
48
Hide members
10.7TNFRSF10B

Compounds for genes affiliated with Pancreatic Cancer

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1vegf4413.2KRAS, MMP2, CDKN2A, PLAU, EGFR, STK11
2paraffin4413.0BRCA2, BRCA1, TP53, EGFR, CDKN2A, MMP2
3retinoic acid44 2414.0PPARG, CDKN2A, EGFR, KRAS, TNFRSF10B, TP53
4cisplatin44 49 59 1115.8TNFRSF10B, CDKN2A, AKT2, EGFR, BRCA1, BRCA2
5paclitaxel44 49 1114.6TNFRSF10B, TP53, BRCA1, CDKN2A, EGFR, KRAS
6phosphatidylinositol4412.5AKT2, GLI1, KRAS, PLAU, EGFR, BRCA2
7serine4412.4AKT2, MMP2, BRCA1, TNFRSF10B, SMAD4, STK11
85fluorouracil4412.4CDKN2A, BRCA1, TNFRSF10B, EGFR, KRAS, MMP2
9n acetylcysteine4412.3TNFRSF10B, PPARG, EGFR, MMP2, TP53, PLAU
10ly2940024412.3PPARG, EGFR, TP53, KRAS, AKT2, PLAU
11genistein44 28 59 2 11 2417.3PLAU, CDKN2A, EGFR, BRCA2, BRCA1, PPARG
12progesterone44 59 28 11 2416.3BRCA1, TP53, PLAU, EGFR, MMP2, CDKN2A
13testosterone44 59 11 2415.2BRCA2, CDKN2A, MMP2, SMAD4, BRCA1, PPARG
14oligonucleotide4412.2CDKN2A, SMAD4, TP53, KRAS, BRCA2, BRCA1
15docetaxel44 49 59 1115.1EGFR, CDKN2A, PLAU, BRCA2, BRCA1, TP53
16mg 13244 5913.1EGFR, SMAD4, TP53, CDKN2A, TNFRSF10B, BRCA1
17curcumin4412.1PLAU, MMP2, EGFR, PPARG, TNFRSF10B, TP53
18alanine4412.1BRCA1, PLAU, MMP2, CDKN2A, STK11, PPARG
19sb 20358044 5913.1PPARG, MMP2, PLAU, TP53, EGFR, AKT2
20doxorubicin44 49 1114.0BRCA1, TNFRSF10B, TP53, CDKN2A, EGFR, PLAU
21thymidine44 2413.0TNFRSF10B, BRCA1, PLAU, BRCA2, SMAD4, TP53
22oxaliplatin44 49 1113.9EGFR, BRCA1, TNFRSF10B, KRAS, TP53
23irinotecan44 49 1113.9TP53, CDKN2A, KRAS, EGFR, TNFRSF10B
24adpribose4411.9EGFR, BRCA1, TNFRSF10B, BRCA2, TP53
25gemcitabine44 49 1113.9TP53, EGFR, BRCA1, MMP2, TNFRSF10B
265-methylcytosine44 2412.7STK11, CDKN2A, TP53, BRCA1
27h2o24411.7KRAS, MMP2, CDKN2A, TNFRSF10B
28temozolomide44 1112.7EGFR, MMP2, TP53, CDKN2A
29o6-methylguanine4411.7TP53, KRAS, BRCA2, CDKN2A
30crcs4411.7CDKN2A, TP53, KRAS, SMAD4
31topotecan44 1112.7BRCA1, EGFR, TP53, TNFRSF10B
32suberoylanilide hydroxamic acid4411.6TNFRSF10B, EGFR, PPARG, TP53
33flavopiridol44 1112.6CDKN2A, TP53, EGFR, TNFRSF10B
34celecoxib44 59 28 49 11 2416.6EGFR, TNFRSF10B, PPARG, MMP2
35bortezomib44 1112.6BRCA1, EGFR, TP53, TNFRSF10B
36pdtc4411.6TP53, PLAU, PPARG, MMP2
37adriamycin4411.5CDKN2A, TNFRSF10B, PLAU
38hydroxyurea44 49 1113.5TP53, CDKN2A, BRCA2, BRCA1
39sp 60012544 5912.5MMP2, TNFRSF10B, TP53, PLAU
40thymidylate4411.4BRCA1, EGFR, CDKN2A, TP53
41etoposide44 49 59 1114.3TNFRSF10B, BRCA1, BRCA2
42cycloheximide4411.3BRCA2, BRCA1
43camptothecin44 59 1113.3TP53, BRCA2, BRCA1, CDKN2A
44tamoxifen44 49 28 1114.2AKT2, EGFR
45sulindac sulfide4411.2TP53, TNFRSF10B, PPARG
46rapamycin4411.2KRAS, EGFR, STK11, PPARG, AKT2
47bcnu4411.1TP53, CDKN2A, EGFR
48resveratrol44 59 11 2414.0BRCA2
49vincristine44 49 1113.0BRCA2, BRCA1
50marimastat44 59 1113.0PLAU, MMP2, EGFR

GO Terms for genes affiliated with Pancreatic Cancer

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16Gene Ontology
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Cellular components related to Pancreatic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.9STK11, PPARG, BRCA2, BRCA1, KLF10, EGFR
2nucleoplasmGO:00565411.9BRCA2, PPARG, CDKN2A, PALB2, SMAD4, TP53
3protein complexGO:04323411.4TP53, CDKN2A, STK11, BRCA2, BRCA1

Biological processes related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589312.2BRCA1, BRCA2, PPARG, GLI1, CDKN2A, SMAD4
2positive regulation of transcription from RNA polymerase II promoterGO:04594412.2BRCA1, PPARG, EGFR, GLI1, CDKN2A, SMAD4
3negative regulation of cell growthGO:03030811.8TP53, SMAD4, CDKN2A, STK11, PPARG
4negative regulation of cell proliferationGO:00828511.7KLF10, STK11, CDKN2A, SMAD4, TP53
5negative regulation of transcription, DNA-dependentGO:04589211.7TP53, SMAD4, CDKN2A, PPARG, BRCA1
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697811.4BRCA1, BRCA2, TP53
7positive regulation of cell cycle arrestGO:07115811.4TP53, CDKN2A, BRCA1
8double-strand break repair via homologous recombinationGO:00072411.3PALB2, BRCA2, BRCA1
9double-strand break repairGO:00630211.2BRCA1, BRCA2, TP53
10Ras protein signal transductionGO:00726511.2TP53, KRAS, CDKN2A
11activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691911.1CDKN2A, PPARG, TNFRSF10B
12response to lipidGO:03399311.1PPARG, STK11
13inner cell mass cell proliferationGO:00183310.9PALB2, BRCA2
14positive regulation of protein phosphorylationGO:00193410.8KRAS, AKT2, EGFR
15replicative senescenceGO:09039910.8CDKN2A, TP53

Molecular functions related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.2TP53, KLF10, BRCA1, BRCA2, TNFRSF10B, PPARG
2DNA bindingGO:00367712.1KLF10, BRCA1, PPARG, GLI1, CDKN2A, PALB2
3transcription regulatory region DNA bindingGO:04421211.7BRCA1, PPARG, GLI1, SMAD4, TP53
4chromatin bindingGO:00368211.6PPARG, EGFR, GLI1, SMAD4, TP53
5enzyme bindingGO:01989911.3TP53, EGFR, PPARG, BRCA1
6p53 bindingGO:00203911.0STK11, CDKN2A, TP53
7MDM2/MDM4 family protein bindingGO:09737111.0TP53, CDKN2A
8LRR domain bindingGO:03027510.6KRAS, STK11

Products for genes affiliated with Pancreatic Cancer

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Sources for Pancreatic Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet