MCID: PNC035
MIFTS: 91

Pancreatic Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Gastrointestinal diseases, Endocrine diseases categories
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Summaries for Pancreatic Cancer

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The pancreas is a gland behind your stomach and in front of your spine. it produces the juices that help break down food and the hormones that help control blood sugar levels. pancreatic cancer usually begins in the cells that produce the juices. some risk factors for developing pancreatic cancer include smoking long-term diabetes chronic pancreatitis certain hereditary disorders pancreatic cancer is hard to catch early. it doesn't cause symptoms right away. when you do get symptoms, they are often vague or you may not notice them. they include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it. because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. possible treatments include surgery, radiation, chemotherapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Pancreatic Cancer, also known as pancreatic carcinoma, is related to pancreatitis and adenocarcinoma. An important gene associated with Pancreatic Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Integrated Breast Cancer Pathway and Integrated Pancreatic Cancer Pathway. The drugs octreotide and octreotide acetate and the compounds vegf and paraffin have been mentioned in the context of this disorder. Affiliated tissues include the pancreas, pancreas and skin, and related mouse phenotypes are tumorigenesis and nervous system.

Disease Ontology:8 An endocrine gland cancer located in the pancreas.

NIH Rare Diseases:43 Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. the pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. possible treatments include surgery, radiation, and chemotherapy. last updated: 9/17/2013

Wikipedia:65 Pancreatic cancer is when cancer cells develop from the pancreas, a glandular organ located behind the... more...

Description from OMIM:47 260350,606856,613347,613348,614320

Aliases & Classifications for Pancreatic Cancer

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
pancreatic cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood
familial pancreatic carcinoma:
Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

pancreatic cancer 8 9 43 47 10 45 49 34
pancreatic carcinoma 8 45 49 62
pancreatic neoplasm 8 62
pancreatic tumor 8 45
cancer pancreas 43 22
malignant neoplasm of body of pancreas 8
malignant neoplasm of tail of pancreas 8
malignant neoplasm of head of pancreas 8
malignant tumor of body of pancreas 8
malignant tumor of tail of pancreas 8
pancreatic carcinoma, familial 62
malignant neoplasm of pancreas 62
familial pancreatic carcinoma 49
exocrine pancreas carcinoma 8
familial pancreatic cancer 49
cancer of the pancreas 43
carcinoma of pancreas 8
neoplasm of pancreas 8
ca head of pancreas 8
ca body of pancreas 8
malignant neoplasms 62
ca tail of pancreas 8
pancreas neoplasm 8


External Ids:

Disease Ontology8 DOID:1793, DOID:4905
NCIt40 C3305, C3850
ICD10 via Orphanet26 C25
SNOMED-CT via Orphanet59 372142002
UMLS via Orphanet63 C0235974, C2931038
MESH via Orphanet36 D010190, C535837

Related Diseases for Pancreatic Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pancreatic Cancer family:

Pancreatic Carcinoma, Familial Pancreatic Cancer 1
Pancreatic Cancer 3 Pancreatic Cancer 4

Diseases related to Pancreatic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 297)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.7SMAD4, BRCA2, KRAS
2adenocarcinoma30.8MMP2, SMAD4, STK11, PLAU, KRAS, CDKN2A
3melanoma30.8STK11, PLAU, MMP2, BRCA2, TP53, TNFRSF10B
4breast cancer30.7BRCA2, BRCA1
5ovarian cancer30.3TNFRSF10B, TP53, CDKN2A, KRAS, PLAU, MMP2
6retinoblastoma30.3EGFR, PPARG, BRCA2, TP53, BRCA1, KRAS
7papillary carcinoma30.3SMAD4, PPARG, BRCA2
8lynch syndrome30.3BRCA2, BRCA1
9cystadenoma30.3KRAS, BRCA1
10colorectal cancer30.3KRAS, CDKN2A, EGFR, SLC29A1, PLAU, STK11
11adenoma30.2KRAS, PPARG, SMAD4, TNFRSF10B, STK11, CDKN2A
12colon cancer30.2MMP2, TNFRSF10B, PLAU, KRAS, EGFR, SMAD4
13cholangiocarcinoma30.2SMAD4, KRAS, TP53
14lung cancer30.1EGFR, PLAU, MMP2, STK11, TP53, KRAS
15li-fraumeni syndrome30.1CDKN2A, TP53
16bile duct carcinoma30.1CDKN2A, SMAD4
17prostate cancer30.1EGFR, PLAU, SMAD4, MMP2
18pancreatitis, chronic30.1SMAD4, KRAS, BRCA1
19male breast cancer30.1BRCA2, BRCA1
20leukemia30.0KRAS, CDKN2A, SLC29A1, BRCA1, TNFRSF10B, TP53
21familial adenomatous polyposis30.0PPARG, SMAD4, TP53, BRCA1, TNFRSF10B, KRAS
22endotheliitis10.8
23hypoxia10.8
24autoimmune pancreatitis10.6
25duodenitis10.4
26pancreatic carcinoma, somatic10.4
27hereditary pancreatitis10.4
28melanoma-pancreatic cancer syndrome10.4
29hepatitis10.4
30pancreatic ductal adenocarcinoma10.4
31peritonitis10.4
32prostatitis10.3
33pancreatic carcinoma, familial10.3
34hypercalcemia10.3
35obstructive jaundice10.3
36peutz-jeghers syndrome10.3
37diabetes mellitus10.3
38somatostatin analog10.3
39multiple endocrine neoplasia10.3
40duodenal obstruction10.2
41insulin resistance10.2
42von hippel-lindau disease10.2
43acute pancreatitis10.2
44familial melanoma10.2
45hepatitis b10.2
46diphtheria10.2
47pancreatic ductal carcinoma10.2
48humoral hypercalcemia of malignancy10.2
49gastric outlet obstruction10.2
50atypical mole syndrome10.2CDKN2A, PALLD, BRCA2

Graphical network of the top 20 diseases related to Pancreatic Cancer:



Diseases related to pancreatic cancer

Symptoms for Pancreatic Cancer

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Sources:
47OMIM
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Clinical features from OMIM:

260350,606856,613347,613348,614320

Drugs & Therapeutics for Pancreatic Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer

Search NIH Clinical Center for Pancreatic Cancer

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pancreatic Cancer

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22GTR
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Genetic tests related to Pancreatic Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Pancreas22

Anatomical Context for Pancreatic Cancer

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Pancreatic Cancer:

33
Pancreas, Skin, Endothelial, Eye, Liver, Testes, Breast, Lymph node, T cells, Colon, Bone, Prostate, Lung, Myeloid, Monocytes, Bone marrow, Brain, Pituitary, Kidney, Thyroid, Testis, Pancreatic islet, Nk cells, Skeletal muscle

FMA organs/tissues related to Pancreatic Cancer:

14
The pancreas

Animal Models for Pancreatic Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pancreatic Cancer:

37 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.0EGFR, PPARG, SMAD4, TNFRSF10B, TP53, BRCA2
2MP:000363111.0BRCA1, BRCA2, TP53, SMAD4, PPARG, HOXB2
3MP:000538411.0BRCA1, BRCA2, TP53, TNFRSF10B, SMAD4, PPARG
4MP:001076811.0BRCA2, TP53, TNFRSF10B, SMAD4, PPARG, HOXB2
5MP:000538011.0HOXB2, PPARG, SMAD4, TP53, BRCA2, BRCA1
6MP:000537811.0BRCA1, BRCA2, TP53, SMAD4, PPARG, HOXB2
7MP:000537611.0BRCA2, TP53, SCTR, TNFRSF10B, SMAD4, PPARG
8MP:000539711.0PPARG, SMAD4, TNFRSF10B, SCTR, TP53, BRCA2
9MP:000536911.0HOXB2, PPARG, SMAD4, TP53, BRCA1, MMP2
10MP:000538711.0TP53, SCTR, TNFRSF10B, SMAD4, PPARG, BRCA2
11MP:001077110.9PPARG, SMAD4, TP53, BRCA2, BRCA1, PALB2
12MP:000539010.9HOXB2, PPARG, TP53, BRCA2, BRCA1, MMP2
13MP:000537910.9BRCA2, TP53, SMAD4, PPARG, BRCA1, STK11
14MP:000538110.9SMAD4, TP53, BRCA2, BRCA1, STK11, PLAU
15MP:000538810.9HOXB2, TP53, BRCA1, MMP2, STK11, PLAU
16MP:000287310.9HOXB2, PPARG, SMAD4, TP53, BRCA2, BRCA1
17MP:000538910.8PPARG, SMAD4, TP53, BRCA2, BRCA1, STK11
18MP:000539110.8HOXB2, PPARG, TP53, MMP2, STK11, PLAU
19MP:000538610.8SCTR, SMAD4, PPARG, HOXB2, TP53, BRCA2
20MP:000538510.8BRCA1, TP53, SMAD4, PPARG, PALB2, MMP2
21MP:000537010.7PPARG, SMAD4, TP53, STK11, PLAU, KRAS
22MP:000536710.7PPARG, SMAD4, SCTR, TP53, BRCA1, STK11
23MP:000537110.6TP53, BRCA2, BRCA1, PALB2, KLF10, KRAS
24MP:000301210.6PPARG, TNFRSF10B, TP53, STK11, CDKN2A, EGFR
25MP:000537510.5EGFR, PLAU, BRCA1, TP53, PPARG
26MP:000118610.5TP53, BRCA1, KRAS, CDKN2A, EGFR
27MP:000538210.2HOXB2, TP53, MMP2, STK11, PLAU, EGFR

Publications for Pancreatic Cancer

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52PubMed
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Articles related to Pancreatic Cancer:

(show top 50)    (show all 3297)
idTitleAuthorsYear
1
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
2
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
3
Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. (23299404)
2013
4
High Intensity Focused Ultrasound Treatment for Patients with Local Advanced Pancreatic Cancer. (24088318)
2013
5
Biochanin A reduces pancreatic cancer survival and progression. (24201306)
2013
6
Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. (23598278)
2013
7
Intensifying local radiotherapy for pancreatic cancer-who benefits and how do we select them? (24294503)
2013
8
Gemcitabine induced myositis in patients with pancreatic cancer: case reports and topic review. (21811892)
2012
9
Invasive markers identified by gene expression profiling in pancreatic cancer. (22487523)
2012
10
Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. (22900040)
2012
11
Diagnostic Strategy for Differentiating Autoimmune Pancreatitis From Pancreatic Cancer: Is an Endoscopic Retrograde Pancreatography Essential? (22228050)
2012
12
Expression of miR-216a in pancreatic cancer and its clinical significance]. (23174591)
2012
13
High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. (22036936)
2011
14
Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1I+ under normoxic condition. (21320746)
2011
15
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines. (20138826)
2010
16
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
17
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
18
p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. (19584258)
2009
19
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. (19646419)
2009
20
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
21
Chemokine receptor CCR7 expression correlates with lymph node metastasis in pancreatic cancer. (18544997)
2008
22
Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. (18404646)
2008
23
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
24
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). (16540233)
2007
25
Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro. (17696250)
2007
26
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion. (18163903)
2007
27
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
28
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
29
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. (16721789)
2006
30
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. (16332727)
2006
31
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
32
Survivin expression and its clinical significance in pancreatic cancer. (16202147)
2005
33
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. (15705601)
2005
34
Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer. (15365564)
2004
35
CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. (14749473)
2004
36
NDRG2 expression and mutation in human liver and pancreatic cancers. (15526377)
2004
37
Adenovirus-mediated transfer of a truncated fibroblast growth factor (FGF) type I receptor blocks FGF-2 signaling in multiple pancreatic cancer cell lines. (14707726)
2004
38
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
39
Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. (12594808)
2003
40
The genetics of pancreatic cancer. (12946833)
2003
41
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. (12960962)
2003
42
Vascular endothelial growth factor is increased in ascites from metastatic pancreatic cancer. (11792148)
2002
43
Inflammation and the development of pancreatic cancer. (12020670)
2002
44
cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. (11444827)
2001
45
Induction and expression of cyclin D3 in human pancreatic cancer. (11469683)
2001
46
In vitro and in vivo matrix metalloproteinase production by pancreatic cancer cells and by distant organs. (11729853)
2000
47
Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer. (9252195)
1997
48
Absence of a mutation of the p21/WAF1 gene in human lung and pancreatic cancers. (8613430)
1996
49
Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. (8047987)
1994
50
Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line. (1933884)
1991

Variations for Pancreatic Cancer

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Pancreatic Cancer:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.105G> T (p.Leu35Phe)single nucleotide variantPathogenicrs121912661GRCh37Chr 17, 7579582: 7579582
2KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
3KRASNM_033360.3(KRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
4BRCA1NM_007294.3(BRCA1): c.5266dupC (p.Gln1756Profs)duplicationPathogenic, risk factorrs80357906GRCh37Chr 17, 41209083: 41209083
5SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485
6RBBP8NM_002894.2(RBBP8): c.1009A> G (p.Lys337Glu)single nucleotide variantPathogenicrs121434388GRCh37Chr 18, 20572799: 20572799
7STK11NM_000455.4(STK11): c.108C> A (p.Tyr36Ter)single nucleotide variantPathogenicrs137853079GRCh37Chr 19, 1207020: 1207020
8STK11NM_000455.4(STK11): c.650delC (p.Pro217Argfs)deletionPathogenicrs397518442GRCh37Chr 19, 1220632: 1220632
9STK11NM_000455.4(STK11): c.936delA (p.Lys312Asnfs)deletionPathogenicrs397518443GRCh37Chr 19, 1222999: 1222999
10ACVR1BNM_020328.3(ACVR1B): c.1282_1286delGATGA (p.Asp428Asnfs)deletionPathogenicrs387906389GRCh37Chr 12, 52380624: 52380628
11ACVR1BNM_020328.3: c.1385-502_1515+24del657deletionPathogenicGRCh37Chr 12, 52385145: 52385801
12SMAD4NM_005359.5(SMAD4): c.1072G> T (p.Gly358Ter)single nucleotide variantPathogenicrs121912576GRCh37Chr 18, 48591909: 48591909
13SMAD4NM_005359.5(SMAD4): c.1477G> C (p.Asp493His)single nucleotide variantPathogenicrs121912578GRCh37Chr 18, 48604655: 48604655
14SMAD4NM_005359.5(SMAD4): c.1543A> T (p.Arg515Ter)single nucleotide variantPathogenicrs121912579GRCh37Chr 18, 48604721: 48604721
15BRCA2NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs)deletionPathogenic, risk factorrs80359550GRCh37Chr 13, 32914438: 32914438

Expression for genes affiliated with Pancreatic Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Cancer

Search GEO for disease gene expression data for Pancreatic Cancer.

Pathways for genes affiliated with Pancreatic Cancer

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 5Cell Signaling Technology, 60Thomson Reuters, 55Reactome, 12EMD Millipore, 51PharmGKB, 54R&D Systems, 61Tocris Bioscience, 57SinoBiological
See all sources

Pathways related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6EGFR, SMAD4, TP53, BRCA2, BRCA1, STK11
210.6SMAD4, TP53, BRCA2, BRCA1, STK11, KRAS
310.6PPARG, SMAD4, TP53, BRCA2, MMP2, KRAS
4
Show member pathways
Signaling Pathways in Glioblastoma38
10.6TP53, BRCA2, BRCA1, MMP2, KRAS, CDKN2A
5
Show member pathways
10.6SMAD4, TP53, BRCA2, KRAS, CDKN2A, EGFR
6
Show member pathways
10.6TP53, BRCA2, BRCA1, MMP2, CDKN2A, EGFR
7
Show member pathways
10.6TNFRSF10B, TP53, BRCA1, STK11, CDKN2A, EGFR
810.6TP53, BRCA1, PLAU, KRAS, CDKN2A, EGFR
910.6EGFR, KRAS, STK11, BRCA1, TP53
10
Show member pathways
10.6PPARG, TNFRSF10B, TP53, MMP2, PLAU, CDKN2A
1110.5SMAD4, TP53, KRAS, CDKN2A
12
Show member pathways
10.5CDKN2A, BRCA1, BRCA2, TP53
1310.5TP53, MMP2, PLAU, KRAS, EGFR
14
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.5EGFR, KRAS, STK11, SMAD4
15
Show member pathways
Signal transduction PTEN pathway60
10.5SMAD4, TP53, KRAS, EGFR
16
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.5PPARG, STK11, PLAU, KRAS, EGFR
1710.5SMAD4, TP53, PLAU, CDKN2A
18
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
10.5SMAD4, TP53, PLAU, CDKN2A
1910.5SMAD4, TP53, STK11
20
Show member pathways
DNA damage response38
10.5CDKN2A, BRCA1, TP53, TNFRSF10B
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.5EGFR, KRAS, PLAU, TP53
22
Show member pathways
10.5BRCA1, BRCA2, TP53
2310.5BRCA1, BRCA2, TP53
24
Show member pathways
10.5EGFR, KRAS, SMAD4, PPARG
2510.5SMAD4, TP53, BRCA1
26
Show member pathways
10.5PALB2, BRCA1, BRCA2
27
Show member pathways
10.5BRCA2, BRCA1, PALB2
2810.5BRCA2, BRCA1, PALB2
2910.5TNFRSF10B, TP53, MMP2, EGFR
30
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
10.5CDKN2A, BRCA1, SMAD4
31
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
10.5SMAD4, TP53, EGFR
32
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
10.5EGFR, KRAS, TP53
3310.5TP53, KRAS, EGFR
3410.5TP53, KRAS, EGFR
3510.5TP53, MMP2, CDKN2A
3610.5TP53, CDKN2A, EGFR
37
Show member pathways
10.5PPARG, TP53, KRAS
3810.5PPARG, TP53, KRAS
39
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
10.5KRAS, TP53, PPARG
4010.5KRAS, SMAD4, PPARG
4110.5EGFR, BRCA1, SMAD4
42
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
10.5CDKN2A, TP53, TNFRSF10B
43
Show member pathways
10.5TNFRSF10B, TP53, BRCA1
4410.5BRCA1, MMP2, PLAU
45
Show member pathways
10.5TP53, CDKN2A
4610.5TP53, CDKN2A
4710.5TP53, BRCA1
4810.5BRCA1, TP53
49
Show member pathways
10.5MMP2, PLAU, EGFR
50
Show member pathways
EGFR-dependent Endothelin signaling events38
10.5EGFR, KRAS

Compounds for genes affiliated with Pancreatic Cancer

About this section
Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
See all sources

Compounds related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1vegf4511.1EGFR, HOXB2, PPARG, SMAD4, TNFRSF10B, TP53
2paraffin4511.1CDKN2A, KRAS, PLAU, MMP2, BRCA1, SMAD4
3estrogen4511.1PLAU, EGFR, CDKN2A, KRAS, KLF10, SMAD4
4serine4511.1TNFRSF10B, TP53, BRCA1, MMP2, STK11, PLAU
5retinoic acid45 2412.1HOXB2, PPARG, TP53, BRCA2, BRCA1, MMP2
6cycloheximide4511.0PPARG, TNFRSF10B, TP53, BRCA2, MMP2, EGFR
7paclitaxel45 51 1113.0SLC29A1, TNFRSF10B, TP53, KRAS, BRCA2, BRCA1
85fluorouracil4511.0CDKN2A, MMP2, BRCA1, TNFRSF10B, TP53, EGFR
9cisplatin45 51 61 1114.0TNFRSF10B, EGFR, CDKN2A, PLAU, KRAS, BRCA1
10h2o24511.0TNFRSF10B, TP53, PLAU, BRCA2, BRCA1, MMP2
11adriamycin4511.0TNFRSF10B, CDKN2A, PLAU, BRCA1, BRCA2, TP53
12n acetylcysteine4511.0CDKN2A, MMP2, TP53, PPARG, EGFR, PLAU
13docetaxel45 51 61 1114.0CDKN2A, TP53, BRCA2, PLAU, BRCA1, EGFR
14gemcitabine45 51 1113.0TNFRSF10B, TP53, MMP2, EGFR, SLC29A1, BRCA1
15mg 13245 6112.0SMAD4, TP53, BRCA1, CDKN2A, EGFR, TNFRSF10B
16genistein45 29 61 3 24 1116.0EGFR, BRCA1, BRCA2, PPARG, PLAU, MMP2
17oxaliplatin45 51 1113.0KRAS, EGFR, TP53, TNFRSF10B, BRCA1
18thymidine45 2412.0TP53, TNFRSF10B, SMAD4, BRCA1, PLAU, BRCA2
19curcumin4511.0EGFR, PLAU, MMP2, TP53, TNFRSF10B, PPARG
205-methylcytosine45 2411.9TP53, STK11, CDKN2A, BRCA1
21irinotecan45 51 1112.9EGFR, TP53, CDKN2A, TNFRSF10B, KRAS
22adpribose4510.9EGFR, TNFRSF10B, TP53, BRCA2, BRCA1
23o6-methylguanine4510.9CDKN2A, TP53, BRCA2, KRAS
24temozolomide45 1111.9CDKN2A, MMP2, EGFR, TP53
25progesterone45 29 61 24 1114.9BRCA2, BRCA1, CDKN2A, PLAU, EGFR, MMP2
26sb 20358045 6111.9PPARG, SLC29A1, PLAU, TP53, EGFR, MMP2
27thymidylate4510.9EGFR, SLC29A1, CDKN2A, BRCA1, TP53
28crcs4510.9CDKN2A, KRAS, TP53, SMAD4
29resveratrol45 61 24 1113.9PPARG, TP53, BRCA2, MMP2, BRCA1
30egcg4510.9TP53, MMP2, PLAU, EGFR, CDKN2A
31testosterone45 61 24 1113.9PPARG, CDKN2A, BRCA1, BRCA2, SMAD4, EGFR
32ly2940024510.9PPARG, TP53, MMP2, PLAU, KRAS, EGFR
33topotecan45 1111.9TP53, BRCA1, TNFRSF10B, EGFR
34doxorubicin45 51 1112.9TP53, BRCA1, PLAU, EGFR, CDKN2A, TNFRSF10B
35suberoylanilide hydroxamic acid4510.8PPARG, TP53, EGFR, TNFRSF10B
36alanine4510.8PLAU, CDKN2A, MMP2, SMAD4, BRCA1, STK11
37flavopiridol45 1111.8EGFR, TNFRSF10B, CDKN2A, TP53
38celecoxib45 61 29 51 24 1115.8EGFR, MMP2, TNFRSF10B, PPARG
39bortezomib45 51 1112.8BRCA1, EGFR, TP53, TNFRSF10B
40etoposide45 51 61 1113.8BRCA2, TP53, BRCA1, MMP2, TNFRSF10B
41pdtc4510.8MMP2, PLAU, TP53, PPARG
42hydroxyurea45 51 1112.7BRCA2, BRCA1, TP53, CDKN2A
43butyrate4510.7CDKN2A, KRAS, PLAU, TP53, TNFRSF10B
44tamoxifen45 51 29 1113.7EGFR, BRCA2, BRCA1, PLAU, TP53
45sp 60012545 6111.6TNFRSF10B, TP53, MMP2, PLAU
46vincristine45 51 1112.6BRCA1, CDKN2A, TP53, BRCA2
47sulindac sulfide4510.5PPARG, TNFRSF10B, TP53
48marimastat45 61 1112.5EGFR, PLAU, MMP2
49bcnu4510.4CDKN2A, EGFR, TP53
50camptothecin45 61 1112.2TP53, CDKN2A, BRCA1, BRCA2

GO Terms for genes affiliated with Pancreatic Cancer

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Sources:
16Gene Ontology
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Cellular components related to Pancreatic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6EGFR, HOXB2, PPARG, SMAD4, TP53, BRCA2
2protein complexGO:04323410.5CDKN2A, BRCA1, BRCA2, TP53
3nucleoplasmGO:00565410.3PPARG, SMAD4, TP53, BRCA2, BRCA1, PALB2

Biological processes related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-templatedGO:04589310.9PPARG, SMAD4, TP53, BRCA2, BRCA1, CDKN2A
2negative regulation of cell growthGO:03030810.9CDKN2A, STK11, TP53, SMAD4, PPARG
3negative regulation of cell proliferationGO:00828510.9SMAD4, TP53, STK11, KLF10, CDKN2A
4positive regulation of transcription from RNA polymerase II promoterGO:04594410.9PPARG, SMAD4, TP53, BRCA1, CDKN2A, EGFR
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.9TP53, BRCA2, BRCA1
6negative regulation of transcription, DNA-templatedGO:04589210.9PPARG, SMAD4, TP53, BRCA1, CDKN2A
7positive regulation of cell cycle arrestGO:07115810.9CDKN2A, BRCA1, TP53
8double-strand break repair via homologous recombinationGO:00072410.8PALB2, BRCA1, BRCA2
9double-strand break repairGO:00630210.8BRCA1, BRCA2, TP53
10Ras protein signal transductionGO:00726510.8CDKN2A, KRAS, TP53
11response to lipidGO:03399310.8PPARG, STK11
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.8PPARG, TNFRSF10B, CDKN2A
13cell proliferationGO:00828310.8SMAD4, TP53, KLF10, EGFR
14replicative senescenceGO:09039910.8CDKN2A, TP53
15inner cell mass cell proliferationGO:00183310.7PALB2, BRCA2
16transforming growth factor beta receptor signaling pathwayGO:00717910.7KLF10, TP53, SMAD4
17cell cycle arrestGO:00705010.7TP53, STK11, CDKN2A
18response to X-rayGO:01016510.7BRCA2, TP53
19regulation of apoptotic processGO:04298110.6BRCA1, TP53, TNFRSF10B
20intrinsic apoptotic signaling pathway by p53 class mediatorGO:07233210.6TP53, STK11
21cellular response to DNA damage stimulusGO:00697410.5STK11, BRCA1, TP53
22positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.5SMAD4, STK11
23response to hypoxiaGO:00166610.4PLAU, MMP2, SMAD4
24positive regulation of DNA repairGO:04573910.2BRCA1, EGFR

Molecular functions related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9EGFR, PPARG, SMAD4, TNFRSF10B, TP53, BRCA2
2transcription regulatory region DNA bindingGO:04421210.7BRCA1, TP53, SMAD4, PPARG
3p53 bindingGO:00203910.6TP53, STK11, CDKN2A
4MDM2/MDM4 family protein bindingGO:09737110.6CDKN2A, TP53
5chromatin bindingGO:00368210.5EGFR, TP53, SMAD4, PPARG
6LRR domain bindingGO:03027510.5KRAS, STK11
7enzyme bindingGO:01989910.4PPARG, TP53, BRCA1, EGFR
8DNA bindingGO:00367710.3PPARG, SMAD4, TP53, BRCA1, PALB2, KLF10

Products for genes affiliated with Pancreatic Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet