MCID: PNC035
MIFTS: 95

Pancreatic Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Gastrointestinal diseases, Endocrine diseases categories

Summaries for Pancreatic Cancer

About this section


OMIM:47 Pancreatic cancer shows among the highest mortality rates of any cancer, with a 5-year relative survival rate of less... (260350) more...

MalaCards based summary: Pancreatic Cancer, also known as pancreatic carcinoma, familial, is related to pancreatitis and adenocarcinoma, and has symptoms including neoplasm of the pancreas An important gene associated with Pancreatic Cancer is SMAD4 (SMAD family member 4), and among its related pathways are Pathways in cancer and Integrated Pancreatic Cancer Pathway. The drugs octreotide and octreotide acetate and the compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include the pancreas, pancreas and endothelial, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:10 An endocrine gland cancer located in the pancreas.

NIH Rare Diseases:43 Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. the pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. possible treatments include surgery, radiation, and chemotherapy. last updated: 9/17/2013

MedlinePlus:34 The pancreas is a gland behind your stomach and in front of your spine. it produces the juices that help break down food and the hormones that help control blood sugar levels. pancreatic cancer usually begins in the cells that produce the juices. some risk factors for developing pancreatic cancer include smoking long-term diabetes chronic pancreatitis certain hereditary disorders pancreatic cancer is hard to catch early. it doesn't cause symptoms right away. when you do get symptoms, they are often vague or you may not notice them. they include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it. because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. possible treatments include surgery, radiation, chemotherapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

Wikipedia:65 Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to... more...

Description from OMIM:47 613347

Aliases & Classifications for Pancreatic Cancer

About this section
Sources:
47OMIM, 32LifeMap Discovery®, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 24GTR, 22GeneTests, 57SNOMED-CT, 40NCIt, 35MeSH, 29ICD9CM, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Pancreatic Cancer, Aliases & Descriptions:

Name: Pancreatic Cancer 47 32 10 11 43 12 45 49 34
Pancreatic Carcinoma, Familial 43 22 24 62
Pancreatic Carcinoma 10 45 49 62
Malignant Neoplasm of Tail of Pancreas 10 62
Malignant Neoplasm of Body of Pancreas 10 62
Malignant Neoplasm of Head of Pancreas 10 62
Familial Pancreatic Carcinoma 43 49
Exocrine Pancreas Carcinoma 10 62
Pancreatic Cancer, Somatic 47 11
Familial Pancreatic Cancer 43 49
Cancer of the Pancreas 43 62
Carcinoma of Pancreas 10 62
Ca Body of Pancreas 10 62
 
Ca Tail of Pancreas 10 62
Ca Head of Pancreas 10 62
Pancreatic Neoplasm 10 62
Pancreatic Tumor 10 45
Cancer Pancreas 43 24
Malignant Tumor of Body of Pancreas 62
Malignant Tumor of Tail of Pancreas 62
Malignant Neoplasm of Pancreas 62
Pancreatic Carcinoma, Somatic 47
Neoplasm of Pancreas 62
Pancreatic Cancer 2 24
Malignant Neoplasms 62
Pancreas Neoplasm 10


Classifications:



Characteristics (Orphanet epidemiological data):

49
pancreatic cancer:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (Europe),1-9/100000 (Worldwide); Age of onset: Adult
familial pancreatic carcinoma:
Age of onset: Adult


External Ids:

Disease Ontology10 DOID:1793, DOID:4905
NCIt40 C3305, C3850
ICD9CM29 157
Orphanet49 217074, 1333
MESH via Orphanet36 D010190, C535837
ICD10 via Orphanet28 C25
UMLS via Orphanet63 C0235974, C2931038

Related Diseases for Pancreatic Cancer

About this section

Diseases in the Pancreatic Cancer family:

Pancreatic Cancer 1 Pancreatic Cancer 3
Pancreatic Cancer 4

Diseases related to Pancreatic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 280)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.7SMAD4, KRAS, BRCA2
2adenocarcinoma30.9TP53, TNFRSF10B, BRCA1, MMP2, SMAD4, STK11
3melanoma30.9BRCA2, CDKN2A, STK11, TP53, PLAU, KRAS
4breast cancer30.5TP53, BRCA1
5colorectal cancer30.4SMAD4, EGFR, MMP2, TNFRSF10B, TP53, KRAS
6retinoblastoma30.3EGFR, CDKN2A, RBBP8, KRAS, BRCA1, BRCA2
7li-fraumeni syndrome30.3TP53, CDKN2A
8adenoma30.3PPARG, SMAD4, TNFRSF10B, TP53, BRCA1, STK11
9lynch syndrome30.3BRCA1, BRCA2
10cystadenoma30.2BRCA1, KRAS
11cholangiocarcinoma30.2SMAD4, TP53, KRAS
12polyposis, juvenile intestinal30.1STK11, SMAD4
13uveal melanoma30.0CDKN2A, SMAD4, MMP2
14bile duct carcinoma30.0CDKN2A, SMAD4
15prostate cancer30.0PLAU, MMP2, EGFR, SMAD4
16hereditary breast ovarian cancer30.0BRCA2
17glioblastoma30.0SMAD4, PPARG, TNFRSF10B, MMP2, PLAU, CDKN2A
18leukemia30.0SLC29A1, CDKN2A, BRCA1, KRAS, BRCA2, TP53
19laryngeal carcinoma30.0TP53, EGFR, PLAU, MMP2
20endometrial cancer30.0TP53, CDKN2A, KRAS
21lung cancer30.0EGFR, KRAS, PLAU, MMP2, STK11, TP53
22sarcoma30.0KRAS, BRCA2, TNFRSF10B, TP53
23endotheliitis10.8
24hypoxia10.8
25autoimmune pancreatitis10.7
26duodenitis10.5
27insulin-like growth factor i10.5
28pancreatic cancer/melanoma syndrome10.4
29pancreatic ductal adenocarcinoma10.4
30hepatitis10.4
31peritonitis10.4
32prostatitis10.4
33duodenal obstruction10.4
34peutz-jeghers syndrome10.3
35hypercalcemia10.3
36obstructive jaundice10.3
37pancreatic cancer 410.3
38gastric outlet obstruction10.3
39multiple endocrine neoplasia10.3
40pancreatic cancer 110.2
41pancreatic cancer 310.2
42hepatitis b10.2
43acute pancreatitis10.2
44cholelithiasis10.2
45diphtheria10.2
46disseminated intravascular coagulation10.2
47pancreatic signet ring cell adenocarcinoma10.2
48adenosquamous pancreas carcinoma10.2
49obesity10.2
50duodenal ulcer10.2

Graphical network of the top 20 diseases related to Pancreatic Cancer:



Diseases related to pancreatic cancer

Symptoms for Pancreatic Cancer

About this section

Symptoms by clinical synopsis from OMIM:

260350

Clinical features from OMIM:

260350,613347

HPO human phenotypes related to Pancreatic Cancer:

id Description Frequency HPO Source Accession
1 neoplasm of the pancreas HP:0002894

Drugs & Therapeutics for Pancreatic Cancer

About this section

Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer

Search NIH Clinical Center for Pancreatic Cancer

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pancreatic Cancer

About this section

Genetic tests related to Pancreatic Cancer:

id Genetic test Affiliating Genes
1 Familial Pancreatic Cancer22
2 Carcinoma of Pancreas24
3 Pancreatic Cancer 224
4 Familial Pancreatic Carcinoma24

Anatomical Context for Pancreatic Cancer

About this section

MalaCards organs/tissues related to Pancreatic Cancer:

33
Pancreas, Endothelial, Skin, Eye, Breast, Colon, Liver, Testes, Lymph node, T cells, Bone, Prostate, Lung, Neutrophil, Monocytes, Myeloid, Bone marrow, Brain, Pituitary, Kidney, Thyroid, Testis, Nk cells, Pancreatic islet, Skeletal muscle

FMA organs/tissues related to Pancreatic Cancer:

16
The pancreas

Animal Models for Pancreatic Cancer or affiliated genes

About this section

MGI Mouse Phenotypes related to Pancreatic Cancer:

37 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.3EGFR, ACVR1B, PLAU, KLF10, KRAS, RBBP8
2MP:001076811.3RBBP8, CDKN2A, TP53, EGFR, KRAS, PLAU
3MP:000200611.3KRAS, STK11, PLAU, KLF10, BRCA2, RBBP8
4MP:000363111.2TP53, SMAD4, PPARG, BRCA2, BRCA1, MMP2
5MP:000538011.2BRCA1, PALB2, EGFR, PALLD, STK11, SMAD4
6MP:000537811.2PPARG, SMAD4, TP53, BRCA2, BRCA1, PALB2
7MP:001077111.2PPARG, BRCA1, BRCA2, TP53, SMAD4, PALB2
8MP:000538711.2PPARG, BRCA2, SMAD4, BRCA1, MMP2, STK11
9MP:000537911.1EGFR, CDKN2A, KRAS, PLAU, STK11, BRCA1
10MP:000537611.1TP53, KRAS, EGFR, CDKN2A, KLF10, PLAU
11MP:000539711.1STK11, TNFRSF10B, TP53, BRCA2, BRCA1, MMP2
12MP:000538911.1SMAD4, TP53, BRCA2, BRCA1, STK11, ACVR1B
13MP:000538111.1EGFR, SMAD4, TP53, BRCA2, BRCA1, STK11
14MP:000536911.1CDKN2A, PPARG, EGFR, KRAS, PLAU, STK11
15MP:000539011.0CDKN2A, KLF10, PLAU, FAM3C, MMP2, BRCA1
16MP:000287311.0SMAD4, KRAS, EGFR, PPARG, STK11, MMP2
17MP:000538811.0STK11, PLAU, ACVR1B, CDKN2A, MMP2, BRCA1
18MP:000538511.0PALB2, EGFR, KRAS, PLAU, STK11, PPARG
19MP:000537010.9CDKN2A, EGFR, KRAS, PLAU, STK11, TP53
20MP:000301210.9STK11, SLC29A1, PPARG, TNFRSF10B, EGFR, TP53
21MP:000537110.8KLF10, EGFR, TP53, BRCA2, PALB2, BRCA1
22MP:000539110.8PLAU, CDKN2A, KRAS, STK11, MMP2, TP53
23MP:000536710.7EGFR, KRAS, TP53, SMAD4, PPARG, STK11
24MP:000538610.6STK11, BRCA2, KRAS, CDKN2A, SMAD4, PPARG
25MP:000118610.6BRCA1, KRAS, CDKN2A, EGFR, TP53
26MP:000537510.6EGFR, TP53, PPARG, PLAU, BRCA1
27MP:000538210.3EGFR, ACVR1B, PLAU, TP53, MMP2, STK11

Publications for Pancreatic Cancer

About this section

Articles related to Pancreatic Cancer:

(show top 50)    (show all 3461)
idTitleAuthorsYear
1
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors. (24025713)
2014
2
Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. (25402324)
2014
3
Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis. (23555989)
2013
4
Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. (23299404)
2013
5
High Intensity Focused Ultrasound Treatment for Patients with Local Advanced Pancreatic Cancer. (24088318)
2013
6
Biochanin A reduces pancreatic cancer survival and progression. (24201306)
2013
7
Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. (23598278)
2013
8
Intensifying local radiotherapy for pancreatic cancer-who benefits and how do we select them? (24294503)
2013
9
MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. (23519249)
2012
10
Gemcitabine induced myositis in patients with pancreatic cancer: case reports and topic review. (21811892)
2012
11
Invasive markers identified by gene expression profiling in pancreatic cancer. (22487523)
2012
12
Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. (22900040)
2012
13
Diagnostic Strategy for Differentiating Autoimmune Pancreatitis From Pancreatic Cancer: Is an Endoscopic Retrograde Pancreatography Essential? (22228050)
2012
14
Expression of miR-216a in pancreatic cancer and its clinical significance]. (23174591)
2012
15
High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. (22036936)
2011
16
Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1I+ under normoxic condition. (21320746)
2011
17
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines. (20138826)
2010
18
Enhanced antitumor effect of combined gemcitabine and proton radiation in the treatment of pancreatic cancer. (19506533)
2009
19
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
20
NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. (19646419)
2009
21
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
22
Chemokine receptor CCR7 expression correlates with lymph node metastasis in pancreatic cancer. (18544997)
2008
23
Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. (18404646)
2008
24
Role of BRCA1 and BRCA2 mutations in pancreatic cancer. (16973716)
2007
25
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). (16540233)
2007
26
Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro. (17696250)
2007
27
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer. (16865243)
2006
28
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. (16568310)
2006
29
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. (16721789)
2006
30
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. (16332727)
2006
31
Hereditary pancreatitis and secondary screening for early pancreatic cancer. (16358943)
2005
32
Survivin expression and its clinical significance in pancreatic cancer. (16202147)
2005
33
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. (15705601)
2005
34
Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer. (15365564)
2004
35
CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. (14749473)
2004
36
NDRG2 expression and mutation in human liver and pancreatic cancers. (15526377)
2004
37
Adenovirus-mediated transfer of a truncated fibroblast growth factor (FGF) type I receptor blocks FGF-2 signaling in multiple pancreatic cancer cell lines. (14707726)
2004
38
Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. (12900367)
2003
39
Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. (12594808)
2003
40
The genetics of pancreatic cancer. (12946833)
2003
41
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. (12960962)
2003
42
Vascular endothelial growth factor is increased in ascites from metastatic pancreatic cancer. (11792148)
2002
43
Inflammation and the development of pancreatic cancer. (12020670)
2002
44
cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. (11444827)
2001
45
Induction and expression of cyclin D3 in human pancreatic cancer. (11469683)
2001
46
In vitro and in vivo matrix metalloproteinase production by pancreatic cancer cells and by distant organs. (11729853)
2000
47
Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer. (9252195)
1997
48
Absence of a mutation of the p21/WAF1 gene in human lung and pancreatic cancers. (8613430)
1996
49
Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. (8047987)
1994
50
Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line. (1933884)
1991

Variations for Pancreatic Cancer

About this section

Clinvar genetic disease variations for Pancreatic Cancer:

7 (show all 27)
id Gene Variation Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.105G> T (p.Leu35Phe)single nucleotide variantPathogenicrs121912661GRCh37Chr 17, 7579582: 7579582
2KRASNM_033360.3(KRAS): c.35G> A (p.Gly12Asp)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
3KRASNM_033360.3(KRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenic, drug responsers121913529GRCh37Chr 12, 25398284: 25398284
4PALB2NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter)single nucleotide variantPathogenicrs180177097GRCh38Chr 16, 23635519: 23635519
5PALB2NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs)deletionPathogenicrs515726065GRCh38Chr 16, 23635232: 23635232
6PALB2NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs)deletionPathogenic, risk factorrs180177143GRCh38Chr 16, 23637886: 23637889
7PALB2PALB2: c.2515-1G> Tsingle nucleotide variantLikely pathogenic, Pathogenic, risk factorGRCh38Chr 16, 23629276: 23629276
8PALB2PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45)deletionPathogenicGRCh38Chr 16, 23603162: 23603162
9PALB2NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter)single nucleotide variantPathogenic, risk factorGRCh38Chr 16, 23607958: 23607958
10PALB2NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs)deletionPathogenicrs180177138GRCh37Chr 16, 23614844: 23614844
11PALB2NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs)deletionPathogenicrs515726124GRCh38Chr 16, 23636036: 23636037
12PALB2NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs)deletionPathogenicrs180177142GRCh38Chr 16, 23638106: 23638106
13PALB2NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs)deletionPathogenicrs180177092GRCh38Chr 16, 23635788: 23635789
14BRCA1NM_007294.3(BRCA1): c.68_69delAG (p.Glu23Valfs)deletionPathogenic, risk factorrs80357713GRCh37Chr 17, 41276047: 41276048
15BRCA1NM_007294.3(BRCA1): c.5266dupC (p.Gln1756Profs)duplicationPathogenic, risk factorrs80357906GRCh37Chr 17, 41209083: 41209083
16SMAD4NM_005359.5(SMAD4): c.1236C> G (p.Tyr412Ter)single nucleotide variantPathogenicrs121912577GRCh37Chr 18, 48593485: 48593485
17PALLDNM_001166110.1(PALLD): c.415C> T (p.Pro139Ser)single nucleotide variantrisk factorrs121908291GRCh37Chr 4, 169799457: 169799457
18RBBP8NM_002894.2(RBBP8): c.1009A> G (p.Lys337Glu)single nucleotide variantPathogenicrs121434388GRCh37Chr 18, 20572799: 20572799
19STK11NM_000455.4(STK11): c.108C> A (p.Tyr36Ter)single nucleotide variantPathogenicrs137853079GRCh37Chr 19, 1207020: 1207020
20STK11NM_000455.4(STK11): c.650delC (p.Pro217Argfs)deletionPathogenicrs397518442GRCh37Chr 19, 1220632: 1220632
21STK11NM_000455.4(STK11): c.936delA (p.Lys312Asnfs)deletionPathogenicrs397518443GRCh37Chr 19, 1222999: 1222999
22ACVR1BNM_020328.3(ACVR1B): c.1282_1286delGATGA (p.Asp428Asnfs)deletionPathogenicrs387906389GRCh37Chr 12, 52380624: 52380628
23ACVR1BNM_020328.3: c.1385-502_1515+24del657deletionPathogenicGRCh37Chr 12, 52385145: 52385801
24SMAD4NM_005359.5(SMAD4): c.1072G> T (p.Gly358Ter)single nucleotide variantPathogenicrs121912576GRCh37Chr 18, 48591909: 48591909
25SMAD4NM_005359.5(SMAD4): c.1477G> C (p.Asp493His)single nucleotide variantPathogenicrs121912578GRCh37Chr 18, 48604655: 48604655
26SMAD4NM_005359.5(SMAD4): c.1543A> T (p.Arg515Ter)single nucleotide variantPathogenicrs121912579GRCh37Chr 18, 48604721: 48604721
27BRCA2NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs)deletionPathogenic, risk factorrs80359550GRCh37Chr 13, 32914438: 32914438

Expression for genes affiliated with Pancreatic Cancer

About this section

Search GEO for disease gene expression data for Pancreatic Cancer.

Pathways for genes affiliated with Pancreatic Cancer

About this section

Pathways related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7CDKN2A, EGFR, PPARG, KRAS, SMAD4, TP53
210.7BRCA1, SMAD4, TP53, BRCA2, STK11, KRAS
310.7KRAS, EGFR, STK11, BRCA1, BRCA2, TP53
4
Show member pathways
Signaling Pathways in Glioblastoma38
10.7EGFR, KRAS, MMP2, BRCA1, BRCA2, TP53
5
Show member pathways
10.7SMAD4, BRCA2, KRAS, CDKN2A, TP53, EGFR
6
Show member pathways
10.6EGFR, CDKN2A, PLAU, MMP2, TP53, TNFRSF10B
7
Show member pathways
10.6MMP2, BRCA1, BRCA2, TP53, CDKN2A, EGFR
810.6PLAU, EGFR, CDKN2A, KRAS, BRCA1, TP53
9
Show member pathways
10.6BRCA1, TP53, STK11, CDKN2A, EGFR, TNFRSF10B
10
Show member pathways
10.6RBBP8, CDKN2A, BRCA2, BRCA1, TP53
1110.6TP53, EGFR, KRAS, STK11, BRCA1
12
Show member pathways
10.6SMAD4, PPARG, EGFR, KRAS, ACVR1B
1310.6EGFR, KRAS, PLAU, MMP2, TP53
14
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.6PPARG, STK11, PLAU, KRAS, EGFR
1510.6SMAD4, CDKN2A, KRAS, TP53
16
Show member pathways
10.6ACVR1B, BRCA1, TP53, SMAD4
17
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.6KRAS, SMAD4, STK11, EGFR
18
Show member pathways
10.6RBBP8, BRCA1, BRCA2, TP53
19
Show member pathways
Signal transduction PTEN pathway60
10.6TP53, SMAD4, KRAS, EGFR
20
Show member pathways
10.6TP53, ACVR1B, KRAS, EGFR
21
Show member pathways
MAPK signaling pathway38
10.6TP53, ACVR1B, KRAS, EGFR
22
Show member pathways
10.6KRAS, ACVR1B, TP53, PPARG
2310.6CDKN2A, PLAU, TP53, SMAD4
24
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
10.6TP53, CDKN2A, SMAD4, PLAU
25
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.6TP53, PLAU, KRAS, EGFR
26
Show member pathways
10.6EGFR, PPARG, SMAD4, ACVR1B
27
Show member pathways
DNA damage response38
10.6TP53, TNFRSF10B, BRCA1, CDKN2A
2810.6EGFR, TP53, MMP2, TNFRSF10B
2910.6SMAD4, ACVR1B, KRAS
3010.6SMAD4, TP53, STK11
3110.6TP53, SMAD4, BRCA1
3210.6TP53, BRCA2, BRCA1
33
Show member pathways
10.6PALB2, BRCA1, BRCA2
3410.6PALB2, BRCA2, BRCA1
3510.6BRCA1, RBBP8, TP53
36
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
10.6CDKN2A, BRCA1, SMAD4
37
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
10.6TP53, EGFR, SMAD4
3810.6KRAS, PPARG, SMAD4
3910.6EGFR, KRAS, TP53
40
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
10.6TP53, EGFR, KRAS
4110.6BRCA1, SMAD4, EGFR
4210.6KRAS, PPARG, TP53
43
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
10.6PPARG, TP53, KRAS
4410.6CDKN2A, TP53, MMP2
4510.6BRCA1, PLAU, RBBP8
4610.6TP53, EGFR, CDKN2A
4710.5PLAU, BRCA1, MMP2
48
Show member pathways
10.5MMP2, EGFR, PLAU
4910.5BRCA1, TP53
50
Show member pathways
EGFR-dependent Endothelin signaling events38
10.5KRAS, EGFR

Compounds for genes affiliated with Pancreatic Cancer

About this section

Compounds related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1serine4511.2CDKN2A, MANF, PLAU, ACVR1B, STK11, MMP2
2vegf4511.2BRCA1, MMP2, TNFRSF10B, TP53, PPARG, STK11
3estrogen4511.2CDKN2A, KRAS, KLF10, PLAU, BRCA2, MMP2
4paraffin4511.2CDKN2A, SMAD4, TP53, BRCA2, PLAU, EGFR
5retinoic acid45 2612.2MMP2, BRCA1, PLAU, KRAS, CDKN2A, EGFR
6cycloheximide4511.1MMP2, CDKN2A, PLAU, BRCA1, BRCA2, EGFR
7paclitaxel45 51 1313.1TP53, KRAS, CDKN2A, BRCA2, BRCA1, EGFR
85fluorouracil4511.1CDKN2A, EGFR, KRAS, TP53, BRCA1, TNFRSF10B
9cisplatin45 51 61 1314.1CDKN2A, KRAS, PLAU, BRCA1, BRCA2, TP53
10h2o24511.1TP53, KRAS, TNFRSF10B, BRCA2, BRCA1, MMP2
11n acetylcysteine4511.1CDKN2A, PLAU, MMP2, TNFRSF10B, EGFR, TP53
12alanine4511.1PLAU, MMP2, BRCA1, SMAD4, ACVR1B, PPARG
13adriamycin4511.1TNFRSF10B, CDKN2A, PLAU, BRCA1, BRCA2, TP53
14docetaxel45 51 61 1314.1CDKN2A, PLAU, TP53, BRCA2, BRCA1, EGFR
15gemcitabine45 51 1313.1SLC29A1, EGFR, MMP2, BRCA1, TP53, TNFRSF10B
16mg 13245 6112.1SMAD4, TNFRSF10B, BRCA1, TP53, EGFR, CDKN2A
17genistein45 30 61 3 26 1316.1BRCA1, MMP2, PPARG, EGFR, PLAU, CDKN2A
18thymidine45 2612.0TP53, SMAD4, TNFRSF10B, BRCA2, SLC29A1, PLAU
19curcumin4511.0PPARG, EGFR, PLAU, MMP2, TNFRSF10B, TP53
20oxaliplatin45 51 1313.0EGFR, KRAS, TP53, BRCA1, TNFRSF10B
21irinotecan45 51 1313.0TP53, CDKN2A, EGFR, TNFRSF10B, KRAS
22adpribose4511.0EGFR, BRCA2, BRCA1, TP53, TNFRSF10B
23progesterone45 30 61 26 1315.0BRCA1, MMP2, EGFR, TP53, CDKN2A, PLAU
245-methylcytosine45 2612.0BRCA1, STK11, TP53, CDKN2A
25sb 20358045 6112.0TP53, PPARG, SLC29A1, EGFR, PLAU, MMP2
26o6-methylguanine4511.0CDKN2A, KRAS, BRCA2, TP53
27temozolomide45 1312.0TP53, EGFR, MMP2, CDKN2A
28thymidylate4511.0SLC29A1, TP53, BRCA1, CDKN2A, EGFR
29testosterone45 61 26 1314.0EGFR, BRCA2, SMAD4, BRCA1, MMP2, CDKN2A
30resveratrol45 61 26 1314.0BRCA1, TP53, MMP2, BRCA2, PPARG
31crcs4511.0CDKN2A, KRAS, SMAD4, TP53
32ly2940024510.9PPARG, MMP2, PLAU, KRAS, EGFR, TP53
33egcg4510.9MMP2, PLAU, TP53, CDKN2A, EGFR
34doxorubicin45 51 1312.9TP53, EGFR, CDKN2A, PLAU, BRCA1, TNFRSF10B
35topotecan45 1311.9EGFR, TP53, BRCA1, TNFRSF10B
36suberoylanilide hydroxamic acid4510.9PPARG, EGFR, TNFRSF10B, TP53
37flavopiridol45 1311.9EGFR, CDKN2A, TP53, TNFRSF10B
38celecoxib45 61 30 51 26 1315.8MMP2, TNFRSF10B, PPARG, EGFR
39bortezomib45 51 1312.8TP53, EGFR, BRCA1, TNFRSF10B
40etoposide45 51 61 1313.8BRCA2, TP53, TNFRSF10B, BRCA1, MMP2
41pdtc4510.8PLAU, PPARG, TP53, MMP2
42hydroxyurea45 51 1312.8BRCA2, CDKN2A, BRCA1, TP53
43butyrate4510.8TNFRSF10B, KRAS, CDKN2A, PLAU, TP53
44tamoxifen45 51 30 1313.8TP53, EGFR, BRCA2, BRCA1, PLAU
45sp 60012545 6111.7PLAU, TNFRSF10B, MMP2, TP53
46vincristine45 51 1312.7CDKN2A, TP53, BRCA2, BRCA1
47sulindac sulfide4510.6PPARG, TNFRSF10B, TP53
48marimastat45 61 1312.5EGFR, PLAU, MMP2
49bcnu4510.5EGFR, CDKN2A, TP53
50camptothecin45 61 1312.3CDKN2A, BRCA1, BRCA2, TP53

GO Terms for genes affiliated with Pancreatic Cancer

About this section

Cellular components related to Pancreatic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:000563410.7EGFR, PPARG, SMAD4, TP53, BRCA2, BRCA1
2protein complexGO:004323410.6CDKN2A, BRCA1, BRCA2, TP53
3nucleoplasmGO:000565410.4PPARG, SMAD4, TP53, BRCA2, BRCA1, PALB2

Biological processes related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:004594411.0EGFR, CDKN2A, ACVR1B, BRCA1, SMAD4, PPARG
2negative regulation of cell growthGO:003030811.0SMAD4, CDKN2A, ACVR1B, STK11, PPARG, TP53
3positive regulation of transcription, DNA-templatedGO:004589311.0CDKN2A, PPARG, SMAD4, BRCA2, BRCA1, TP53
4negative regulation of cell proliferationGO:000828511.0TP53, KLF10, STK11, SMAD4, CDKN2A
5double-strand break repair via homologous recombinationGO:000072411.0PALB2, BRCA2, BRCA1, RBBP8
6negative regulation of transcription, DNA-templatedGO:004589211.0CDKN2A, BRCA1, TP53, SMAD4, PPARG
7negative regulation of transcription from RNA polymerase II promoterGO:000012210.9SMAD4, TP53, KLF10, RBBP8, PPARG
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.9BRCA2, TP53, BRCA1
9positive regulation of cell cycle arrestGO:007115810.9CDKN2A, BRCA1, TP53
10double-strand break repairGO:000630210.9BRCA2, TP53, BRCA1
11DNA repairGO:000628110.9BRCA1, BRCA2, RBBP8, PALB2
12Ras protein signal transductionGO:000726510.9CDKN2A, KRAS, TP53
13response to lipidGO:003399310.9PPARG, STK11
14cell proliferationGO:000828310.9TP53, KLF10, EGFR, SMAD4
15activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.9PPARG, TNFRSF10B, CDKN2A
16replicative senescenceGO:009039910.8TP53, CDKN2A
17cell cycle checkpointGO:000007510.8CDKN2A, RBBP8
18transforming growth factor beta receptor signaling pathwayGO:000717910.8KLF10, SMAD4, TP53
19inner cell mass cell proliferationGO:000183310.8BRCA2, PALB2
20cell cycle arrestGO:000705010.8TP53, CDKN2A, STK11
21response to X-rayGO:001016510.8BRCA2, TP53
22regulation of apoptotic processGO:004298110.8TNFRSF10B, TP53, BRCA1
23intrinsic apoptotic signaling pathway by p53 class mediatorGO:007233210.7STK11, TP53
24positive regulation of transforming growth factor beta receptor signaling pathwayGO:003051110.7STK11, SMAD4
25G1/S transition of mitotic cell cycleGO:000008210.7ACVR1B, CDKN2A, RBBP8
26response to hypoxiaGO:000166610.6PLAU, MMP2, SMAD4
27cellular response to DNA damage stimulusGO:000697410.6TP53, BRCA1, STK11
28protein autophosphorylationGO:004677710.6ACVR1B, EGFR, STK11
29positive regulation of DNA repairGO:004573910.4EGFR, BRCA1
30G2 DNA damage checkpointGO:003157210.2RBBP8, BRCA1

Molecular functions related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:000551511.1PALB2, EGFR, CDKN2A, RBBP8, KRAS, KLF10
2transcription regulatory region DNA bindingGO:004421210.8BRCA1, TP53, SMAD4, PPARG
3p53 bindingGO:000203910.7TP53, STK11, CDKN2A
4MDM2/MDM4 family protein bindingGO:009737110.6CDKN2A, TP53
5LRR domain bindingGO:003027510.6STK11, KRAS
6enzyme bindingGO:001989910.6TP53, EGFR, BRCA1, PPARG
7DNA bindingGO:000367710.6TP53, BRCA1, KLF10, SMAD4, PPARG, CDKN2A
8ubiquitin protein ligase bindingGO:003162510.6TP53, BRCA1, ACVR1B
9chromatin bindingGO:000368210.3TP53, PPARG, SMAD4, EGFR

Products for genes affiliated with Pancreatic Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Pancreatic Cancer

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet