MCID: PNC035
MIFTS: 82

Pancreatic Cancer malady

Cancer, Gastrointestinal categories

Summaries for Pancreatic Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 The pancreas is a gland behind your stomach and in front of your spine. it produces the juices that help break down food and the hormones that help control blood sugar levels. pancreatic cancer usually begins in the cells that produce the juices. some risk factors for developing pancreatic cancer include smoking long-term diabetes chronic pancreatitis certain hereditary disorders pancreatic cancer is hard to catch early. it doesn't cause symptoms right away. when you do get symptoms, they are often vague or you may not notice them. they include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it. because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. possible treatments include surgery, radiation, chemotherapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Pancreatic Cancer, also known as pancreatic carcinoma, is related to pancreatitis, chronic and colorectal cancer. An important gene associated with Pancreatic Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Pathways in cancer and Apoptotic Pathways in Synovial Fibroblasts. The drugs octreotide and octreotide acetate and the compounds vegf and paraffin have been mentioned in the context of this disorder. Affiliated tissues include the pancreas, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An endocrine gland cancer located in the pancreas.

NIH Rare Diseases:43 Pancreatic cancer occurs when cells of the pancreas grow abnormally to form a tumor. the pancreas is a gland that normally makes juices that help break down food and produces insulin and other hormones. pancreatic cancer usually doesn't cause symptoms right away, but can cause yellowing of the skin and eyes, pain in the abdomen and back, weight loss, and fatigue. some risk factors for developing pancreatic cancer include smoking, long-term diabetes, chronic pancreatitis, and certain hereditary disorders. because pancreatic cancer is often found late and it spreads quickly, it can be hard to treat. possible treatments include surgery, radiation, and chemotherapy. last updated: 9/17/2013

Wikipedia:64 Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming... more...

Description from OMIM:47 260350,606856,613347,613348,614320

Aliases & Classifications for Pancreatic Cancer

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
pancreatic cancer:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood
familial pancreatic carcinoma:
Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

pancreatic cancer 8 9 43 47 10 45 49 34
pancreatic carcinoma 8 45 49 61
pancreatic neoplasm 8 61
pancreatic tumor 8 45
cancer pancreas 43 22
malignant neoplasm of tail of pancreas 8
malignant neoplasm of body of pancreas 8
malignant neoplasm of head of pancreas 8
malignant tumor of tail of pancreas 8
malignant tumor of body of pancreas 8
pancreatic carcinoma, familial 61
malignant neoplasm of pancreas 61
familial pancreatic carcinoma 49
exocrine pancreas carcinoma 8
familial pancreatic cancer 49
cancer of the pancreas 43
carcinoma of pancreas 8
neoplasm of pancreas 8
ca tail of pancreas 8
ca head of pancreas 8
malignant neoplasms 61
ca body of pancreas 8
pancreas neoplasm 8


External Ids:

Disease Ontology8 DOID:1793, DOID:4905
NCIt40 C3305, C3850
ICD10 via Orphanet26 C25
SNOMED-CT via Orphanet58 372142002
UMLS via Orphanet62 C0235974, C2931038
MESH via Orphanet36 D010190, C535837

Related Diseases for Pancreatic Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pancreatic Cancer family:

pancreatic cancer 1 pancreatic cancer 3
pancreatic cancer 4

Diseases related to Pancreatic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 506)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis, chronic31.1BRCA1, KRAS, SMAD4
2colorectal cancer30.8BRCA1, BRCA2, TNFRSF10B, PPARG, STK11, EGFR
3adenocarcinoma30.8EGFR, STK11, SCTR, TNFRSF10B, BRCA2, BRCA1
4nasopharynx carcinoma30.8CDKN2A, TP53
5oral cancer30.6EGFR, CDKN2A, MMP2, PLAU, TP53
6acute leukemia30.5KRAS
7peutz-jeghers syndrome30.5STK11, BRCA2
8hepatitis c30.4KRAS
9multiple endocrine neoplasia30.4BRCA2
10biliary tract cancer30.3SMAD4, EGFR
11atypical mole syndrome30.2PALLD, CDKN2A, BRCA2
12adenoma30.2BRCA1, TNFRSF10B, PPARG, STK11, CDKN2A, KRAS
13stomach cancer30.1TP53
14brain cancer30.1EGFR, GLI1, PLAU, TP53
15peritoneal carcinoma30.1BRCA1, BRCA2
16papillary carcinoma30.1SMAD4, PPARG, BRCA2
17cystadenoma30.1BRCA1, KRAS
18li-fraumeni syndrome30.0CDKN2A, TP53
19familial adenomatous polyposis29.9BRCA1, TNFRSF10B, PPARG, STK11, KRAS, SMAD4
20gastrinoma29.9SMAD4, SCTR
21squamous cell carcinoma29.9AKT2, EGFR, STK11, TNFRSF10B, MANF, GLI1
22thyroid cancer29.9TP53, PPARG
23testicular cancer29.9KRAS, STK11
24bile duct carcinoma29.9SMAD4, CDKN2A
25wilms tumor29.9BRCA2
26basal cell carcinoma29.9GLI1
27bladder carcinoma29.9TP53, CDKN2A
28male breast cancer29.9BRCA2, BRCA1
29tuberous sclerosis29.9STK11
30ductal carcinoma in situ29.8BRCA1, BRCA2, EGFR, TP53
31bladder carcinoma in situ29.8EGFR, CDKN2A, MMP2, TP53
32familial colorectal cancer29.8BRCA1, BRCA2, CDKN2A
33atherosclerosis29.8PLAU, MMP2, PPARG
34oropharyngeal cancer, adult29.8CDKN2A, TP53
35neurofibromatosis29.8KRAS
36transitional cell carcinoma29.8EGFR, PLAU, TP53
37vascular cancer10.8
38pancreatic cancer 110.8
39hypoxia10.8
40autoimmune pancreatitis10.7
41tongue cancer10.6
42pancreatic endocrine tumors10.5
43pancreatic cancer 310.5
44pancreatic carcinoma, familial10.5
45melanoma-pancreatic cancer syndrome10.4
46pancreatic carcinoma, somatic10.4
47somatostatin analog10.4
48pancreatic cancer 410.4
49obstructive jaundice10.3
50familial melanoma10.3

Graphical network of the top 20 diseases related to Pancreatic Cancer:



Diseases related to pancreatic cancer

Clinical Features for Pancreatic Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

260350,606856,613347,613348,614320

Drugs & Therapeutics for Pancreatic Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pancreatic Cancer

Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer

Search NIH Clinical Center for Pancreatic Cancer

Search CenterWatch for Pancreatic Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pancreatic Cancer

Sources:
22GTR
See all sources

Genetic tests related to Pancreatic Cancer:

id Genetic test Affiliating Genes
1 Carcinoma Of Pancreas22

Anatomical Context for Pancreatic Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Pancreatic Cancer:

14
The pancreas

Animal Models for Pancreatic Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pancreatic Cancer:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538414.1EGFR, STK11, PPARG, TNFRSF10B, BRCA2, BRCA1
2MP:001076814.1AKT2, EGFR, STK11, PPARG, TNFRSF10B, BRCA2
3MP:000538713.7BRCA1, BRCA2, TNFRSF10B, SCTR, PPARG, STK11
4MP:000537813.6AKT2, EGFR, STK11, PPARG, BRCA2, BRCA1
5MP:000539713.5BRCA1, BRCA2, TNFRSF10B, SCTR, PPARG, STK11
6MP:000538913.0BRCA1, BRCA2, STK11, EGFR, AKT2, GLI1
7MP:000287313.0STK11, PPARG, BRCA2, BRCA1, EGFR, AKT2
8MP:000200612.9SMAD4, KLF10, TNFRSF10B, PPARG, STK11, EGFR
9MP:000538112.8BRCA1, BRCA2, STK11, EGFR, GLI1, CDKN2A
10MP:001077112.7KLF10, BRCA1, BRCA2, STK11, CDKN2A, KRAS
11MP:000538512.6BRCA1, PPARG, STK11, EGFR, MMP2, PLAU
12MP:000537012.5PPARG, STK11, EGFR, AKT2, CDKN2A, PLAU
13MP:000538812.4BRCA1, EGFR, AKT2, GLI1, MMP2, PLAU
14MP:000538612.2BRCA1, BRCA2, SCTR, PPARG, STK11, GLI1
15MP:000301212.1TNFRSF10B, PPARG, STK11, EGFR, AKT2, GLI1
16MP:000536712.1BRCA1, SCTR, PPARG, STK11, EGFR, GLI1
17MP:000537612.0KLF10, BRCA1, BRCA2, TNFRSF10B, SCTR, AKT2
18MP:000536912.0AKT2, CDKN2A, MMP2, PLAU, SMAD4, TP53
19MP:000537911.9BRCA1, BRCA2, CDKN2A, KRAS, TP53
20MP:000538011.8PPARG, GLI1, PALB2, PALLD, SMAD4
21MP:000539011.8KLF10, BRCA1, BRCA2, FAM3C, AKT2
22MP:000363111.7PPARG, GLI1, PALB2, PALLD
23MP:000537111.2BRCA2, GLI1, PALB2
24MP:000539111.2PPARG, STK11, EGFR, PLAU
25MP:000537510.9PLAU, AKT2

Publications for Pancreatic Cancer

Sources:
51PubMed
See all sources

Articles related to Pancreatic Cancer:

(show top 50)    (show all 3509)
idTitleAuthorsYear
1
Cholecystokinin and pancreatic cancer: the chicken or the egg? (24177032)
2014
2
Second primary pancreatic adenocarcinoma three years after successfully treated index esophageal cancer. (24413784)
2014
3
Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. (24193916)
2014
4
Potential prognostic biomarkers of pancreatic cancer. (24326364)
2014
5
Endoscopic double stenting for the treatment of malignant biliary and duodenal obstruction due to pancreatic cancer. (23617659)
2013
6
Combination Treatment of Human Pancreatic Cancer Xenograft Models with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib and Oncolytic Herpes Simplex Virus HF10. (24170435)
2013
7
A new endoscopic ultrasonography image processing method to evaluate the prognosis for pancreatic cancer treated with interstitial brachytherapy. (24151368)
2013
8
Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer. (24135803)
2013
9
Correction: Digitoflavone Inhibits II_BI+ Kinase and Enhances Apoptosis Induced by TNFI+ through Downregulation of Expression of Nuclear Factor I_B-Regulated Gene Products in Human Pancreatic Cancer Cells. (24204521)
2013
10
Sequential gemcitabine and platinum versus first-line combination of gemcitabine and platinum for advanced pancreatic cancer treatment: a retrospective study. (24077663)
2013
11
Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. (23992308)
2013
12
Disease outcome of patients with pancreatic cancer in a cohort treated outside clinical trials. (24324086)
2013
13
Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer. (22266185)
2012
14
S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells. (23085231)
2012
15
Responses of pancreatic cancer cells to stimulations by nerve growth factor and the role of Trk-A expression]. (22445970)
2012
16
Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer. (21491088)
2011
17
KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. (21571866)
2011
18
Recombinant human bone morphogenetic protein-2 and pancreatic cancer: a retrospective cohort study. (21254281)
2011
19
Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. (20876774)
2011
20
Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. (20100905)
2010
21
Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. (20426791)
2010
22
Marantic Endocarditis Associated with Pancreatic Cancer: A Case Series. (20651968)
2009
23
Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. (19421011)
2009
24
Morbid obesity and subsequent pancreatic cancer: pylorus-preserving pancreatoduodenectomy after laparoscopic sleeve gastrectomy. (18815848)
2009
25
Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin-like growth factor-I pathway. (19874825)
2009
26
Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures. (18646007)
2008
27
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. (18381409)
2008
28
Activation of the alpha2beta1 integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells by shifts in the concentrations of extracellular Mg2+ and Ca2+. (18224679)
2008
29
Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. (18617777)
2008
30
Small molecule tyrosine kinase inhibitors in pancreatic cancer. (19707451)
2008
31
Palladin mutation causes familial pancreatic cancer: absence in European families. (17455999)
2007
32
Effects of base excision repair gene polymorphisms on pancreatic cancer survival. (17230526)
2007
33
Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. (17227797)
2007
34
Shh signaling and pancreatic cancer: implications for therapy? (17611415)
2007
35
Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer. (16704535)
2006
36
Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. (16424023)
2006
37
Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. (16969513)
2006
38
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. (16009488)
2006
39
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. (15701826)
2005
40
Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer. (15548711)
2004
41
Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. (12949733)
2003
42
Increased expression of MUC1 in advanced pancreatic cancer. (14714254)
2003
43
Identification of a trypsinogen activity stimulating factor produced by pancreatic cancer cells: its role in tumor invasion and metastasis. (14612960)
2003
44
Relationship between types of common channel and development of biliary tract cancer in pancreaticobiliary maljunction. (11995442)
2002
45
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. (11159909)
2001
46
Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. (11309315)
2001
47
Ribozyme targeting of HER-2 inhibits pancreatic cancer cell growth in vivo. (11527697)
2001
48
Homozygous deletion map at 18q21.1 in pancreatic cancer. (8564959)
1996
49
p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. (8513440)
1993
50
The epidermal growth factor receptor in human pancreatic cancer. (1538276)
1992

Genetic Variations for Pancreatic Cancer

Expression for genes affiliated with Pancreatic Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pancreatic Cancer

Search GEO for disease gene expression data for Pancreatic Cancer.

Pathways for genes affiliated with Pancreatic Cancer

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 50PharmGKB, 56SinoBiological, 54Reactome, 60Tocris Bioscience
See all sources

Pathways related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.5GLI1, AKT2, EGFR, PPARG, BRCA2, CDKN2A
2
Hide members
12.1EGFR, TNFRSF10B, TP53, PLAU, CDKN2A, MMP2
311.9EGFR, BRCA1, STK11, SMAD4, TP53, BRCA2
411.9EGFR, KRAS, SMAD4, BRCA2, TP53, BRCA1
5
Hide members
11.9EGFR, BRCA2, AKT2, CDKN2A, KRAS, SMAD4
6
Hide members
11.9TP53, STK11, TNFRSF10B, EGFR, AKT2, BRCA1
711.7BRCA1, STK11, EGFR, KRAS, TP53, AKT2
811.7TP53, PLAU, CDKN2A, EGFR, BRCA1, KRAS
911.7EGFR, MMP2, KRAS, TP53, AKT2, PLAU
10
Hide members
11.5BRCA2, TP53, KRAS, AKT2, BRCA1
11
Hide members
11.5TP53, KRAS, SMAD4, AKT2, EGFR
12
Hide members
11.5TP53, BRCA1, AKT2, BRCA2, MMP2
13
Hide members
11.5AKT2, CDKN2A, PLAU, TP53, SMAD4
14
Translation Insulin regulation of translation
Hide members
11.5KRAS, EGFR, PLAU, AKT2, STK11
15
Hide members
11.5AKT2, EGFR, TP53, PLAU, KRAS
16
Hide members
11.3AKT2, KRAS, SMAD4, TP53
1711.3SMAD4, PLAU, CDKN2A, TP53
18
Cell cycle Cell cycle (generic schema)
Hide members
11.3BRCA1, AKT2, CDKN2A, SMAD4
1911.3AKT2, TP53, KRAS, EGFR
20
Hide members
11.3KRAS, TP53, EGFR, AKT2
2111.3KRAS, EGFR, TP53, AKT2
22
Hide members
11.3EGFR, KRAS, AKT2, TP53
2311.3AKT2, CDKN2A, TP53, EGFR
2411.3PPARG, AKT2, KRAS, SMAD4
25
Hide members
11.3TNFRSF10B, TP53, CDKN2A, BRCA1
26
Hide members
11.3AKT2, PLAU, KRAS, BRCA1
27
Development Endothelin-1/EDNRA signaling
Hide members
11.3AKT2, KRAS, EGFR, MMP2
2811.3TNFRSF10B, MMP2, EGFR, TP53
2911.1STK11, SMAD4, TP53
30
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
11.1BRCA1, BRCA2, TP53
3111.1BRCA1, BRCA2, TP53
3211.1KRAS, TP53, CDKN2A
3311.1SMAD4, TP53, BRCA1
3411.1AKT2, STK11, TP53
3511.1PALB2, BRCA2, BRCA1
36
Transcription P53 signaling pathway
Hide members
11.1TP53, MMP2, CDKN2A
3711.1TP53, KRAS, PPARG
38
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1TP53, KRAS, PPARG
3911.1EGFR, BRCA1, SMAD4
4011.1EGFR, TP53, AKT2
41
Transcription Androgen Receptor nuclear signaling
Hide members
11.1MMP2, EGFR, AKT2
4211.1PLAU, MMP2, BRCA1
43
Cell adhesion ECM remodeling
Hide members
11.1EGFR, PLAU, MMP2
4410.9PALB2, TP53
4510.9BRCA1, TP53
46
Hide members
10.9AKT2, KRAS
47
Hide members
10.9AKT2, PPARG
48
Hide members
10.7TNFRSF10B

Compounds for genes affiliated with Pancreatic Cancer

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1vegf4513.2KRAS, MMP2, CDKN2A, PLAU, EGFR, STK11
2paraffin4513.0BRCA2, BRCA1, TP53, EGFR, CDKN2A, MMP2
3retinoic acid45 2414.0PPARG, CDKN2A, EGFR, KRAS, TNFRSF10B, TP53
4cisplatin45 50 60 1115.8TNFRSF10B, CDKN2A, AKT2, EGFR, BRCA1, BRCA2
5paclitaxel45 50 1114.6TNFRSF10B, TP53, BRCA1, CDKN2A, EGFR, KRAS
6phosphatidylinositol4512.5AKT2, GLI1, KRAS, PLAU, EGFR, BRCA2
7serine4512.4AKT2, MMP2, BRCA1, TNFRSF10B, SMAD4, STK11
85fluorouracil4512.4CDKN2A, BRCA1, TNFRSF10B, EGFR, KRAS, MMP2
9n acetylcysteine4512.3TNFRSF10B, PPARG, EGFR, MMP2, TP53, PLAU
10ly2940024512.3PPARG, EGFR, TP53, KRAS, AKT2, PLAU
11genistein45 29 60 2 11 2417.3PLAU, CDKN2A, EGFR, BRCA2, BRCA1, PPARG
12progesterone45 60 29 11 2416.3BRCA1, TP53, PLAU, EGFR, MMP2, CDKN2A
13testosterone45 60 11 2415.2BRCA2, CDKN2A, MMP2, SMAD4, BRCA1, PPARG
14oligonucleotide4512.2CDKN2A, SMAD4, TP53, KRAS, BRCA2, BRCA1
15docetaxel45 50 60 1115.1EGFR, CDKN2A, PLAU, BRCA2, BRCA1, TP53
16mg 13245 6013.1EGFR, SMAD4, TP53, CDKN2A, TNFRSF10B, BRCA1
17curcumin4512.1PLAU, MMP2, EGFR, PPARG, TNFRSF10B, TP53
18alanine4512.1BRCA1, PLAU, MMP2, CDKN2A, STK11, PPARG
19sb 20358045 6013.1PPARG, MMP2, PLAU, TP53, EGFR, AKT2
20doxorubicin45 50 1114.0BRCA1, TNFRSF10B, TP53, CDKN2A, EGFR, PLAU
21thymidine45 2413.0TNFRSF10B, BRCA1, PLAU, BRCA2, SMAD4, TP53
22oxaliplatin45 50 1113.9EGFR, BRCA1, TNFRSF10B, KRAS, TP53
23irinotecan45 50 1113.9TP53, CDKN2A, KRAS, EGFR, TNFRSF10B
24adpribose4511.9EGFR, BRCA1, TNFRSF10B, BRCA2, TP53
25gemcitabine45 50 1113.9TP53, EGFR, BRCA1, MMP2, TNFRSF10B
265-methylcytosine45 2412.7STK11, CDKN2A, TP53, BRCA1
27h2o24511.7KRAS, MMP2, CDKN2A, TNFRSF10B
28temozolomide45 1112.7EGFR, MMP2, TP53, CDKN2A
29o6-methylguanine4511.7TP53, KRAS, BRCA2, CDKN2A
30crcs4511.7CDKN2A, TP53, KRAS, SMAD4
31topotecan45 1112.7BRCA1, EGFR, TP53, TNFRSF10B
32suberoylanilide hydroxamic acid4511.6TNFRSF10B, EGFR, PPARG, TP53
33flavopiridol45 1112.6CDKN2A, TP53, EGFR, TNFRSF10B
34celecoxib45 60 29 50 11 2416.6EGFR, TNFRSF10B, PPARG, MMP2
35bortezomib45 1112.6BRCA1, EGFR, TP53, TNFRSF10B
36pdtc4511.6TP53, PLAU, PPARG, MMP2
37adriamycin4511.5CDKN2A, TNFRSF10B, PLAU
38hydroxyurea45 50 1113.5TP53, CDKN2A, BRCA2, BRCA1
39sp 60012545 6012.5MMP2, TNFRSF10B, TP53, PLAU
40thymidylate4511.4BRCA1, EGFR, CDKN2A, TP53
41etoposide45 50 60 1114.3TNFRSF10B, BRCA1, BRCA2
42cycloheximide4511.3BRCA2, BRCA1
43camptothecin45 60 1113.3TP53, BRCA2, BRCA1, CDKN2A
44tamoxifen45 50 29 1114.2AKT2, EGFR
45sulindac sulfide4511.2TP53, TNFRSF10B, PPARG
46rapamycin4511.2KRAS, EGFR, STK11, PPARG, AKT2
47bcnu4511.1TP53, CDKN2A, EGFR
48resveratrol45 60 11 2414.0BRCA2
49vincristine45 50 1113.0BRCA2, BRCA1
50marimastat45 60 1113.0PLAU, MMP2, EGFR

GO Terms for genes affiliated with Pancreatic Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Pancreatic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.9KLF10, BRCA1, BRCA2, PPARG, STK11, SMAD4
2nucleoplasmGO:00565411.9PALB2, TP53, BRCA1, BRCA2, SMAD4, CDKN2A
3protein complexGO:04323411.4BRCA1, BRCA2, STK11, CDKN2A, TP53

Biological processes related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-dependentGO:04589312.2PPARG, GLI1, CDKN2A, SMAD4, TP53, BRCA2
2positive regulation of transcription from RNA polymerase II promoterGO:04594412.2BRCA1, PPARG, GLI1, EGFR, CDKN2A, SMAD4
3negative regulation of cell growthGO:03030811.8TP53, SMAD4, CDKN2A, STK11, PPARG
4negative regulation of cell proliferationGO:00828511.7SMAD4, KLF10, STK11, CDKN2A, TP53
5negative regulation of transcription, DNA-dependentGO:04589211.7BRCA1, PPARG, TP53, SMAD4, CDKN2A
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697811.4TP53, BRCA2, BRCA1
7positive regulation of cell cycle arrestGO:07115811.4BRCA1, CDKN2A, TP53
8double-strand break repair via homologous recombinationGO:00072411.3BRCA2, BRCA1, PALB2
9double-strand break repairGO:00630211.2TP53, BRCA1, BRCA2
10Ras protein signal transductionGO:00726511.2TP53, KRAS, CDKN2A
11activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691911.1CDKN2A, PPARG, TNFRSF10B
12response to lipidGO:03399311.1PPARG, STK11
13inner cell mass cell proliferationGO:00183310.9BRCA2, PALB2
14positive regulation of protein phosphorylationGO:00193410.8KRAS, EGFR, AKT2
15replicative senescenceGO:09039910.8TP53, CDKN2A

Molecular functions related to Pancreatic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.2STK11, AKT2, GLI1, PPARG, MMP2, TP53
2DNA bindingGO:00367712.1PALB2, TP53, CDKN2A, SMAD4, KLF10, GLI1
3transcription regulatory region DNA bindingGO:04421211.7SMAD4, TP53, GLI1, PPARG, BRCA1
4chromatin bindingGO:00368211.6PPARG, EGFR, GLI1, SMAD4, TP53
5enzyme bindingGO:01989911.3BRCA1, EGFR, TP53, PPARG
6p53 bindingGO:00203911.0STK11, TP53, CDKN2A
7MDM2/MDM4 family protein bindingGO:09737111.0TP53, CDKN2A
8LRR domain bindingGO:03027510.6STK11, KRAS

Products for genes affiliated with Pancreatic Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet