MCID: PNC094
MIFTS: 25

Pancreatic Cancer 1 malady

Endocrine diseases, Cancer diseases categories

Summaries for Pancreatic Cancer 1

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46OMIM, 32MalaCards
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MalaCards: Pancreatic Cancer 1, also known as malignant neoplasm of pancreas, is related to pancreatic cancer and pancreatic ductal carcinoma. An important gene associated with Pancreatic Cancer 1 is PALLD (palladin, cytoskeletal associated protein), and among its related pathways are Apoptosis and Autophagy and Nuclear Receptor transcription pathway. The compounds cd 437 and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, and related mouse phenotypes are tumorigenesis and mortality/aging.

Description from OMIM:46 606856

Aliases & Classifications for Pancreatic Cancer 1

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46OMIM, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

pancreatic cancer 1 46
malignant neoplasm of pancreas 60


Related Diseases for Pancreatic Cancer 1

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Pancreatic Cancer 1:



Diseases related to pancreatic cancer 1

Clinical Features for Pancreatic Cancer 1

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46OMIM
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Clinical features from OMIM:

606856

Drugs & Therapeutics for Pancreatic Cancer 1

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Cancer 1

Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer 1

Search NIH Clinical Center for Pancreatic Cancer 1

Search CenterWatch for Pancreatic Cancer 1

Genetic Tests for Pancreatic Cancer 1

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Anatomical Context for Pancreatic Cancer 1

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pancreatic Cancer 1:

32
Pancreas

Animal Models for Pancreatic Cancer 1 or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pancreatic Cancer 1:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2NR4A1, PPARG, TNFRSF10B
2MP:00107688.0PALLD, NR4A1, PPARG, TNFRSF10B

Publications for Pancreatic Cancer 1

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Genetic Variations for Pancreatic Cancer 1

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Expression for genes affiliated with Pancreatic Cancer 1

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Cancer 1

Search GEO for disease gene expression data for Pancreatic Cancer 1.

Pathways for genes affiliated with Pancreatic Cancer 1

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Sources:
4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NR4A1, TNFRSF10B
2
Hide members
9.1NR4A1, PPARG

Compounds for genes affiliated with Pancreatic Cancer 1

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1cd 437449.6TNFRSF10B, NR4A1
2gw966244 2810.3TNFRSF10B, PPARG
3sulindac sulfide449.3PPARG, TNFRSF10B
4sulindac44 1110.2PPARG, TNFRSF10B
5suberoylanilide hydroxamic acid449.2PPARG, TNFRSF10B
6celecoxib44 59 28 49 11 2414.1PPARG, TNFRSF10B
7acetyl-coa44 2410.0TNFRSF10B, PPARG
8curcumin448.9TNFRSF10B, PPARG
9tacrolimus44 49 1110.8PPARG, NR4A1
10cycloheximide448.7TNFRSF10B, PPARG, NR4A1
11vegf448.6PPARG, NR4A1, TNFRSF10B
12retinoic acid44 249.5NR4A1, TNFRSF10B, PPARG

GO Terms for genes affiliated with Pancreatic Cancer 1

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Sources:
16Gene Ontology
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Biological processes related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.1NR4A1, PPARG
2activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.7PPARG, TNFRSF10B

Molecular functions related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.1NR4A1, PPARG
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048798.8NR4A1, PPARG

Products for genes affiliated with Pancreatic Cancer 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Cancer 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet