MCID: PNC094
MIFTS: 31

Pancreatic Cancer 1 malady

Endocrine, Cancer categories

Summaries for Pancreatic Cancer 1

Sources:
47OMIM, 33MalaCards
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MalaCards: Pancreatic Cancer 1, also known as malignant neoplasm of pancreas, is related to pancreas sarcoma and pancreatic ductal carcinoma. An important gene associated with Pancreatic Cancer 1 is PALLD (palladin, cytoskeletal associated protein), and among its related pathways are Apoptosis and Autophagy and Nuclear Receptor transcription pathway. The compounds cd 437 and gw9662 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, colon and lung, and related mouse phenotypes are tumorigenesis and mortality/aging.

Description from OMIM:47 606856

Aliases & Classifications for Pancreatic Cancer 1

Sources:
47OMIM, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

pancreatic cancer 1 47
malignant neoplasm of pancreas 61


Related Diseases for Pancreatic Cancer 1

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Pancreatic Cancer 1:



Diseases related to pancreatic cancer 1

Clinical Features for Pancreatic Cancer 1

Sources:
47OMIM
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Clinical features from OMIM:

606856

Drugs & Therapeutics for Pancreatic Cancer 1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pancreatic Cancer 1

Drug clinical trials:

Search ClinicalTrials for Pancreatic Cancer 1

Search NIH Clinical Center for Pancreatic Cancer 1

Search CenterWatch for Pancreatic Cancer 1

Genetic Tests for Pancreatic Cancer 1

Anatomical Context for Pancreatic Cancer 1

Sources:
33MalaCards
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MalaCards organs/tissues related to Pancreatic Cancer 1:

33
Lymph node, Colon, Lung, Pancreas, Breast, Prostate, T cells, Endothelial

Animal Models for Pancreatic Cancer 1 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pancreatic Cancer 1:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2NR4A1, PPARG, TNFRSF10B
2MP:00107688.0PALLD, NR4A1, PPARG, TNFRSF10B

Publications for Pancreatic Cancer 1

Sources:
51PubMed
See all sources

Articles related to Pancreatic Cancer 1:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Involvement of microRNA-181b in the gemcitabine resistance of pancreatic cancer cells. (24075517)
2013
2
MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. (24040078)
2013
3
MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2. (23975374)
2013
4
Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010. (24006012)
2013
5
Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer. (24403266)
2013
6
miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKI+1. (23171948)
2013
7
Pancreatic cancer death rates by race among US men and women, 1970-2009. (24203988)
2013
8
Correction: MiR-130b Is a Prognostic Marker and Inhibits Cell Proliferation and Invasion in Pancreatic Cancer through Targeting STAT3. (24086203)
2013
9
The rescue of miR-148a expression in pancreatic cancer: an inappropriate therapeutic tool. (23383211)
2013
10
Pancreatic cancer mortality in Serbia from 1991-2010 - a joinpoint analysis. (23986278)
2013
11
Aberrant expression miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells. (24048456)
2013
12
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation. (22311263)
2012
13
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer. (22128300)
2012
14
HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. (20037603)
2010
15
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (20101243)
2010
16
CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer. (20643596)
2010
17
HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells. (20428829)
2010
18
miR-146a suppresses invasion of pancreatic cancer cells. (20124483)
2010
19
Insulin promotes proliferative vitality and invasive capability of pancreatic cancer cells via hypoxia-inducible factor 1alpha pathway. (20556580)
2010
20
CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. (19035451)
2009
21
Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaB. (19435817)
2009
22
Inhibition of protein synthesis by imexon reduces HIF-1alpha expression in normoxic and hypoxic pancreatic cancer cells. (18607542)
2009
23
siRNA targeting HIF-1alpha induces apoptosis of pancreatic cancer cells through NF-kappaB-independent and -dependent pathways under hypoxic conditions. (19414389)
2009
24
Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications. (18952231)
2009
25
Up-regulation of KrA1ppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. (19671674)
2009
26
Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer. (18376310)
2008
27
Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. (18567618)
2008
28
Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer. (18475302)
2008
29
Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification. (17332321)
2007
30
Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. (17975158)
2007
31
Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. (16504015)
2006
32
Mitochondrial DNA D-loop in pancreatic cancer: somatic mutations are epiphenomena while the germline 16519 T variant worsens metabolism and outcome. (16938655)
2006
33
Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. (16628086)
2006
34
Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha. (16552335)
2006
35
Effect of HIF-1alpha on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic cancer. (17219968)
2006
36
Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. (16000563)
2005
37
Interleukin-1alpha, 6 regulate the secretion of vascular endothelial growth factor A, C in pancreatic cancer. (16109537)
2005
38
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. (16278378)
2005
39
Pancreatic cancer cells invasiveness is mainly affected by interleukin-1beta not by transforming growth factor-beta1. (16398405)
2005
40
Correlation of mRNA expression of hypoxia inducible factor-1alpha to biological features of pancreatic cancer]. (15694030)
2005
41
TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (15547748)
2004
42
Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells. (14679213)
2004
43
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. (15483017)
2004
44
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. (12937141)
2003
45
Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer. (12768332)
2003
46
Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. (12931024)
2003
47
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. (11522653)
2001
48
Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. (8780719)
1996
49
Homozygous deletion map at 18q21.1 in pancreatic cancer. (8564959)
1996
50
Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR-1505), on the growth of freshly separated and xenografted human pancreatic cancer. (8386784)
1993

Genetic Variations for Pancreatic Cancer 1

Expression for genes affiliated with Pancreatic Cancer 1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pancreatic Cancer 1

Search GEO for disease gene expression data for Pancreatic Cancer 1.

Pathways for genes affiliated with Pancreatic Cancer 1

Sources:
4Cell Signaling Technology, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NR4A1, TNFRSF10B
2
Hide members
9.1NR4A1, PPARG

Compounds for genes affiliated with Pancreatic Cancer 1

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1cd 437459.6NR4A1, TNFRSF10B
2gw966245 2910.3PPARG, TNFRSF10B
3sulindac sulfide459.3PPARG, TNFRSF10B
4sulindac45 1110.2TNFRSF10B, PPARG
5suberoylanilide hydroxamic acid459.2PPARG, TNFRSF10B
6celecoxib45 60 29 50 11 2414.1TNFRSF10B, PPARG
7acetyl-coa45 2410.0PPARG, TNFRSF10B
8curcumin458.9PPARG, TNFRSF10B
9tacrolimus45 50 1110.8NR4A1, PPARG
10cycloheximide458.7NR4A1, PPARG, TNFRSF10B
11vegf458.6NR4A1, PPARG, TNFRSF10B
12retinoic acid45 249.5TNFRSF10B, PPARG, NR4A1

GO Terms for genes affiliated with Pancreatic Cancer 1

Sources:
16Gene Ontology
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Biological processes related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.1NR4A1, PPARG
2activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069198.7PPARG, TNFRSF10B

Molecular functions related to Pancreatic Cancer 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.1NR4A1, PPARG
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048798.8NR4A1, PPARG

Products for genes affiliated with Pancreatic Cancer 1

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pancreatic Cancer 1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet