Pancreatic Cancer 2

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 2

MalaCards integrated aliases for Pancreatic Cancer 2:

Name: Pancreatic Cancer 2 54 71 29
Pnca2 71


External Ids:

OMIM 54 613347
MedGen 40 C3150546
MeSH 42 D010190
SNOMED-CT via HPO 65 126859007 363418001

Summaries for Pancreatic Cancer 2

UniProtKB/Swiss-Prot : 71 Pancreatic cancer 2: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 2, also known as pnca2, is related to pancreatic cancer susceptibility 2, and has symptoms including neoplasm of the pancreas An important gene associated with Pancreatic Cancer 2 is BRCA2 (BRCA2, DNA Repair Associated). The drugs Pancrelipase and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and t cells.

Description from OMIM: 613347

Related Diseases for Pancreatic Cancer 2

Diseases in the Pancreatic Cancer family:

Pancreatic Cancer 1 Pancreatic Cancer 2
Pancreatic Cancer 3 Pancreatic Cancer 4

Diseases related to Pancreatic Cancer 2 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 pancreatic cancer susceptibility 2 10.8

Symptoms & Phenotypes for Pancreatic Cancer 2

Clinical features from OMIM:


Human phenotypes related to Pancreatic Cancer 2:

id Description HPO Frequency HPO Source Accession
1 neoplasm of the pancreas 32 HP:0002894

Drugs & Therapeutics for Pancreatic Cancer 2

Drugs for Pancreatic Cancer 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 572)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Pancrelipase Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53608-75-6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 95058-81-4 60750
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33069-62-4 36314
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
Nicotine Approved Phase 4 54-11-5 942 89594
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
Bupropion Approved Phase 4,Phase 2 34841-39-9, 34911-55-2 444
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
Etomidate Approved Phase 4 33125-97-2 36339 667484
Meperidine Approved Phase 4 57-42-1 4058
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Somatostatin Approved Phase 4,Phase 3,Phase 2 38916-34-6, 51110-01-1 53481605
Thrombin Approved Phase 4
Tegafur Approved Phase 4,Phase 2,Phase 1 17902-23-7 5386
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
25 pancreatin Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
26 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
27 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
30 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
31 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
32 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
34 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Phase 1
35 Adjuvants, Anesthesia Phase 4
36 Analgesics, Opioid Phase 4,Phase 2,Phase 1
37 Anesthetics, General Phase 4
38 Anesthetics, Intravenous Phase 4
39 GABA Agents Phase 4,Phase 2
40 Narcotics Phase 4,Phase 2,Phase 1
41 Tranquilizing Agents Phase 4,Phase 2
42 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
43 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
45 Albumin-Bound Paclitaxel Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
48 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Antineoplastic Agents, Phytogenic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1383)

id Name Status NCT ID Phase Drugs
1 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
2 Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Completed NCT01256034 Phase 4
3 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
4 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
5 Dalteparin for Primary Venous Thromboembolism (VTE) Prophylaxis in Pancreatic Cancer Patients Completed NCT00966277 Phase 4 Dalteparin
6 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
7 RCT: Difference in Diagnostic Yield Between EUSFNA Needles With and Without a Side Port in Pancreatic Masses Completed NCT02092519 Phase 4
8 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed NCT00365508 Phase 4 nicotine lozenge;nicotine patch
9 Effects of Dexmedetomidine During IRE Procedures for Solid Tumours Completed NCT02044224 Phase 4 Dexmedetomidine
10 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed NCT00666978 Phase 4 bupropion hydrochloride
11 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
12 Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection Completed NCT01914692 Phase 4 Somatostatin
13 Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients Recruiting NCT02812992 Phase 4 Nab-paclitaxel;Gemcitabine
14 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
15 The Effect of Application of TachoSil® in Pancreatoduodenectomy Recruiting NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch
16 Pre-operative Biliary SEMS RCT During Neoadjuvant Therapy Active, not recruiting NCT02238847 Phase 4
17 Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer Enrolling by invitation NCT01111591 Phase 4 Cox2 inhibitor (Celecoxib)
18 Nimotuzumab Plus S1 Versus Placebo Plus S1 as Maintenance Treatment in Patients With Unresectable Pancreatic Cancer Not yet recruiting NCT02945267 Phase 4 Nimotuzumab plus S1;Placebo plus S1
19 Prevention of Upper Gastrointestinal Hemorrhage Using Albis® in the Patients of Locally Advanced Pancreatic Cancer Who Underwent Concurrent Chemoradiotherapy Not yet recruiting NCT02570529 Phase 4 Albis®;Placebo
20 Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC Not yet recruiting NCT03257033 Phase 4 Gemcitabine;nab-paclitaxel
21 A Study of First Line Treatment With Tarceva (Erlotinib) in Combination With Gemcitabine in Patients With Locally Advanced Unresectable or Metastatic Pancreatic Cancer Terminated NCT00642733 Phase 4 erlotinib [Tarceva];gemcitabine
22 Efficacy Of Pregabalin In The Treatment Of Pancreatic Cancer Pain. A Randomized Controlled Double-Blind, Parallel Group Study Terminated NCT01768988 Phase 4 Placebo;Pregabalin
23 Neoadjuvant GTX With Chemoradiation for Pancreatic Cancer (Stage II/III) Unknown status NCT01065870 Phase 2, Phase 3 Neoadjuvant gemcitabine, capecitabine, and docetaxel;Gemcitabine, capecitabine, docetaxel followed by radiotherapy
24 A Phase 3 Study to Compare Efficacy and Safety of Masitinib in Combination With Gemcitabine, to Placebo in Combination With Gemcitabine, in Treatment of Patients With Advanced/Metastatic Pancreatic Cancer Unknown status NCT00789633 Phase 3 masitinib (AB1010);placebo
25 Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer Unknown status NCT00112658 Phase 2, Phase 3 fluorouracil;gemcitabine hydrochloride;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
26 Capecitabine/Erlotinib Followed of Gemcitabine Versus Gemcitabine/Erlotinib Followed of Capecitabine Unknown status NCT00440167 Phase 3 Gemcitabine;Capecitabine;Erlotinib
27 Induction Chemotherapy, FOLFIRINOX Followed With Concurrent Capecitabine and Radiation Therapy in Inoperable Locally Advanced Cancer of the Pancreas Unknown status NCT02311439 Phase 2, Phase 3 FOLFIRINOX + CRT
28 A Study to See if hENT1 Testing on Tumour Tissue Can Predict Response to Treatment With Gemcitabine Chemotherapy and if a Different Chemotherapy Called FOLFOX is Better Than Gemcitabine in Metastatic Pancreas Cancer Unknown status NCT01586611 Phase 3 5FU, leucovorin, oxaliplatin;Gemcitabine
29 Efficacy and Mechanisms of Acupuncture for Patients With Advanced Pancreatic Cancer Pain Unknown status NCT02510066 Phase 3
30 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Advance or Inoperable Pancreatic Cancer Unknown status NCT00486460 Phase 3 Gemcitabine;Curcumin;Celebrex
31 Gemcitabine or Gemcitabine and Cisplatin in the Treatment of Advanced Pancreatic Cancer Unknown status NCT00813696 Phase 3 gemcitabine;cisplatin
32 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Unknown status NCT00753441 Phase 2, Phase 3
33 Hyperthermia European Adjuvant Trial Unknown status NCT01077427 Phase 3 Gemcitabine
34 Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy Unknown status NCT00809081 Phase 3
35 Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery Unknown status NCT01655641 Phase 2, Phase 3 Tranexamic acid
36 Randomized Study With Oxaliplatin in 2nd Line Pancreatic Cancer Completed NCT01121848 Phase 3 Leucovorin;OXALIPLATIN;5-Fluorouracil
37 An Open Label Study to Evaluate G17DT Compared to Gemcitabine Completed NCT03200821 Phase 3 Gemcitabine
38 Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery Completed NCT00303758 Phase 3 cisplatin;fluorouracil;gemcitabine hydrochloride;leucovorin calcium
39 Gemcitabine With or Without Radiation Therapy in Treating Patients With Pancreatic Cancer Completed NCT00057876 Phase 3 Gemcitabine
40 Gemcitabine and Radiation Therapy Compared With Gemcitabine Alone in Treating Patients Who Have Undergone Surgery for Pancreatic Cancer Completed NCT00064207 Phase 2, Phase 3 gemcitabine hydrochloride
41 Chemotherapy With or Without Enoxaparin in Pancreatic Cancer Completed NCT00785421 Phase 2, Phase 3 enoxaparin;chemotherapy with LMWH - enoxaparin;only chemotherapy
42 Gemcitabine and ON 01910.Na in Previously Untreated Metastatic Pancreatic Cancer Completed NCT01360853 Phase 3 ON 01910.Na;Gemcitabine;Gemcitabine
43 Immunotherapy Study for Surgically Resected Pancreatic Cancer Completed NCT01072981 Phase 3 Gemcitabine
44 Phase III of Gemcitabine Vs TS-1 Vs Gemcitabine Plus TS-1 in Pancreatic Cancer Completed NCT00498225 Phase 3 Gemcitabine plus TS-1;TS-1;Gemcitabine
45 S0205 Gemcitabine w/ or w/o Cetuximab as First-Line Therapy in Locally Advanced Pancreas Cancer Completed NCT00075686 Phase 3 gemcitabine hydrochloride
46 Two Chemotherapy Regimens Compared With Observation in Treating Patients With Completely Resected Pancreatic Cancer Completed NCT00058201 Phase 3 fluorouracil;gemcitabine hydrochloride;leucovorin calcium
47 Irinotecan, Gemcitabine and Radiation Therapy for Pancreatic Cancer Completed NCT00192712 Phase 2, Phase 3 irinotecan, gemcitabine
48 Comparison of Two Needles (ProCore vs EchoTip) for the Diagnosis of Pancreatic Solid Mass Under EUS Completed NCT01479803 Phase 3
49 Gemcitabine With or Without Tipifarnib (R115777) in Treating Patients With Advanced Pancreatic Cancer Completed NCT00005648 Phase 3 Gemcitabine with R115777;Gemcitabine with Placebo
50 Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer Completed NCT00024427 Phase 3 fluorouracil;gemcitabine hydrochloride;triacetyluridine

Search NIH Clinical Center for Pancreatic Cancer 2

Genetic Tests for Pancreatic Cancer 2

Genetic tests related to Pancreatic Cancer 2:

id Genetic test Affiliating Genes
1 Pancreatic Cancer 2 29

Anatomical Context for Pancreatic Cancer 2

MalaCards organs/tissues related to Pancreatic Cancer 2:

Pancreas, Lung, T Cells, Liver, Testes, Prostate, Colon

Publications for Pancreatic Cancer 2

Variations for Pancreatic Cancer 2

ClinVar genetic disease variations for Pancreatic Cancer 2:

id Gene Variation Type Significance SNP ID Assembly Location
1 BRCA2 NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs) deletion Pathogenic rs80359550 GRCh37 Chromosome 13, 32914438: 32914438

Expression for Pancreatic Cancer 2

Search GEO for disease gene expression data for Pancreatic Cancer 2.

Pathways for Pancreatic Cancer 2

GO Terms for Pancreatic Cancer 2

Sources for Pancreatic Cancer 2

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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