MCID: PNC095
MIFTS: 16

Pancreatic Cancer 3

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 3

MalaCards integrated aliases for Pancreatic Cancer 3:

Name: Pancreatic Cancer 3 53 71 28
Pancreatic Cancer, Susceptibility to, 3 53 13
Pnca3 53 71

Classifications:



External Ids:

OMIM 53 613348
MedGen 39 C3150547
MeSH 41 D010190

Summaries for Pancreatic Cancer 3

UniProtKB/Swiss-Prot : 71 Pancreatic cancer 3: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 3, is also known as pancreatic cancer, susceptibility to, 3. An important gene associated with Pancreatic Cancer 3 is PALB2 (Partner And Localizer Of BRCA2). Affiliated tissues include pancreas, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 613348

Related Diseases for Pancreatic Cancer 3

Symptoms & Phenotypes for Pancreatic Cancer 3

Clinical features from OMIM:

613348

GenomeRNAi Phenotypes related to Pancreatic Cancer 3 according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 GDNF PALB2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 GDNF PALB2

Drugs & Therapeutics for Pancreatic Cancer 3

Search Clinical Trials , NIH Clinical Center for Pancreatic Cancer 3

Genetic Tests for Pancreatic Cancer 3

Genetic tests related to Pancreatic Cancer 3:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 3 28 PALB2

Anatomical Context for Pancreatic Cancer 3

MalaCards organs/tissues related to Pancreatic Cancer 3:

38
Pancreas

Publications for Pancreatic Cancer 3

Variations for Pancreatic Cancer 3

ClinVar genetic disease variations for Pancreatic Cancer 3:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 PALB2 NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter) single nucleotide variant Pathogenic,risk factor rs180177097 GRCh38 Chromosome 16, 23635519: 23635519
2 PALB2 NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs) deletion Pathogenic rs515726065 GRCh38 Chromosome 16, 23635232: 23635232
3 PALB2 NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs) deletion risk factor rs180177143 GRCh38 Chromosome 16, 23637886: 23637889
4 PALB2 PALB2: c.2515-1G> T single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776417 GRCh38 Chromosome 16, 23629276: 23629276
5 PALB2 NM_024675.3(PALB2): c.3116delA (p.Asn1039Ilefs) deletion Pathogenic/Likely pathogenic,risk factor rs180177133 GRCh38 Chromosome 16, 23614089: 23614089
6 PALB2 PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45) deletion Pathogenic GRCh38 Chromosome 16, 23603162: 23608012
7 PALB2 NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776527 GRCh38 Chromosome 16, 23607958: 23607958
8 PALB2 NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs) deletion Pathogenic rs180177138 GRCh38 Chromosome 16, 23603523: 23603523
9 PALB2 NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs) deletion Pathogenic rs515726123 GRCh38 Chromosome 16, 23636036: 23636037
10 PALB2 NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs) deletion Pathogenic rs180177142 GRCh38 Chromosome 16, 23638106: 23638106
11 PALB2 NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs) deletion Pathogenic rs180177092 GRCh38 Chromosome 16, 23635788: 23635789
12 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh38 Chromosome 16, 23635306: 23635306
13 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
14 PALB2 NM_024675.3(PALB2): c.3549C> G (p.Tyr1183Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs118203998 GRCh37 Chromosome 16, 23614792: 23614792

Expression for Pancreatic Cancer 3

Search GEO for disease gene expression data for Pancreatic Cancer 3.

Pathways for Pancreatic Cancer 3

GO Terms for Pancreatic Cancer 3

Biological processes related to Pancreatic Cancer 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.62 GDNF PALB2

Sources for Pancreatic Cancer 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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